Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainHMGI/Y_DNA-bd_CS

PRB1 PRB3 PRB4 PRB2

8.05e-0731444IPR000637
DomainPro-rich

PRR4 PRB1

1.62e-053442SM01412
DomainPro-rich

PRR4 PRB1

1.62e-053442PF15240
DomainPro-rich

PRR4 PRB1

1.62e-053442IPR026086
Pubmed

The involvement of proline-rich protein Mus musculus predicted gene 4736 in ocular surface functions.

PRB1 PRB3 PRB4 PRB2

2.44e-12445427588265
Pubmed

Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over.

PRB1 PRB3 PRB4 PRB2

2.44e-1244542851479
Pubmed

Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system.

PRB1 PRB3 PRB4 PRB2

3.66e-1164542993301
Pubmed

The structure and evolution of the human salivary proline-rich protein gene family.

PRB1 PRB4 PRB2

2.02e-0934538422499
Pubmed

Molecular genetics of human salivary proteins and their polymorphisms.

PRB1 PRB3 PRB4

2.02e-0934533055850
Pubmed

cDNA clones for mouse parotid proline-rich proteins. mRNA regulation by isoprenaline and the nucleotide sequence of proline-rich protein cDNA MP5.

PRB1 PRB3 PRB4

8.09e-0944531339347
Pubmed

The intriguing heterogeneity of human salivary proline-rich proteins: Short title: Salivary proline-rich protein species.

PRB3 PRB4 PRB2

2.02e-08545326375204
Pubmed

NANOS2 promotes male germ cell development independent of meiosis suppression.

PRB3 PRB4 PRB2

1.63e-061845324183939
Pubmed

Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases.

PRB3 PRB4

1.64e-06245218463091
Pubmed

Fractionation and characterization of basic proline-rich peptides of human parotid saliva and the amino acid sequence of proline-rich peptide P-E.

PRB1 PRB2

1.64e-0624527118863
Pubmed

Enhanced glycosylation and sulfation of secretory proteoglycans is coupled to the expression of a basic secretory protein.

PRB1 PRB4

1.64e-0624529487127
Pubmed

Salivary proline-rich proteins.

PRB1 PRB4

1.64e-0624526810092
Pubmed

PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins.

PRB4 PRB2

1.64e-0624528554050
Pubmed

Basic proline-rich proteins from human parotid saliva: complete covalent structure of protein IB-9 and partial structure of protein IB-6, members of a polymorphic pair.

PRB1 PRB2

1.64e-0624526924859
Pubmed

Clones from the human gene complex coding for salivary proline-rich proteins.

PRB1 PRB2

1.64e-0624526089212
Pubmed

EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation.

RNF25 NKD2

4.91e-06345218757723
Pubmed

Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases.

PRB1 PRB4

4.91e-06345211422372
Pubmed

Finding new posttranslational modifications in salivary proline-rich proteins.

PRB3 PRB4

9.81e-06445220879038
Pubmed

Basic proline-rich proteins from human parotid saliva: relationships of the covalent structures of ten proteins from a single individual.

PRB4 PRB2

9.81e-0644521849422
Pubmed

Correct expression and localization of collagen XIII are crucial for the normal formation and function of the neuromuscular system.

CACNA1A COL13A1

3.42e-05745230667565
Pubmed

Multiple roles of integrin-α3 at the neuromuscular junction.

CACNA1A BSN

1.07e-041245228386022
Pubmed

Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.

CACNA1A BSN

1.47e-041445221228161
Pubmed

A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.

COL13A1 BSN

1.94e-041645225082827
Pubmed

Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.

ZBTB38 BSN

3.06e-042045220846217
Pubmed

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.

ZNF598 GLE1 EIF4G1

3.66e-0410745330995489
Pubmed

Transcriptome analysis of human gastric cancer.

FRS3 RNF216 FHDC1 COL13A1 GLE1 CCNC

4.57e-0477245616341674
Pubmed

Protein interactome reveals converging molecular pathways among autism disorders.

FRS3 TUT4 NKD2 CEP89 CNTRL

7.63e-0456045521653829
Pubmed

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.

PRR4 TUT4 GLE1

9.58e-0414945322664934
Pubmed

The Vertebrate Genome Annotation browser 10 years on.

TUT4 RAB44 INVS

1.24e-0316345324316575
Cytoband12p13.2

PRB1 PRB3 PRB4 PRB2

1.16e-074545412p13.2
CytobandEnsembl 112 genes in cytogenetic band chr12p13

PRR4 PRB1 PRB3 PRB4 PRB2

2.48e-05353455chr12p13
GeneFamilyProline rich proteins

PRB1 PRB3 PRB4 PRB2

1.06e-106314972
CoexpressionTRAVAGLINI_LUNG_SEROUS_CELL

PRR4 PRB1 PRB3 PRB4 PRB2

6.45e-0796455M41657
CoexpressionMEBARKI_HCC_PROGENITOR_FZD8CRD_UP

FHDC1 ADAMTS5 MB21D2 PLEKHO1 MN1 ARHGAP31 TK1 CRACDL

6.34e-06588458M38992
CoexpressionAtlassalivary gland

PRR4 PRB1 PRB3 PRB4 PRB2

8.73e-0783455salivary gland
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-SMG_serous_secreting_cell-SMG_serous_(nasal)-SMG_serous_(nasal)_L.0.6.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRR4 PRB1 PRB3 PRB4 PRB2 CCNC

3.50e-0818845602b3aae071ff1f469d52a4d513a4eb46ae70bba3
ToppCell3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_tracheobronchial_serous_cell-SMG_serous_(bronchial)-SMG_serous_(bronchial)_L.0.6.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRR4 PRB1 PRB3 PRB4 PRB2 CCNC

3.96e-0819245648b69d6f46e583378186d2993a202f9584688bfa
ToppCell3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_tracheobronchial_serous_cell-SMG_serous_(bronchial)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRR4 PRB1 PRB3 PRB4 PRB2 CCNC

4.08e-0819345656145861ef5e7655db9ad0d11b82f72dcadf285d
ToppCell3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_tracheobronchial_serous_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRR4 PRB1 PRB3 PRB4 PRB2 CCNC

4.08e-081934563d1710a6060d3a70994a206334ccb16cd63e5f20
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Serous|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

PRR4 FHDC1 PRB1 PRB3 PRB4 PRB2

5.05e-0820045661bae10c8b12196d9cee766897971b81cb897191
ToppCellSerous|World / shred by cell class for bronchial biopsy

PRR4 PRB1 PRB3 PRB4 PRB2

1.16e-0618445509d0d1525c11dd326efd942684c03f79d992cf3b
ToppCellcellseq-Epithelial-Epithelial_Glandular-Serous|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PRR4 PRB1 PRB3 PRB4 PRB2

1.16e-06184455f0cbb5b76e092be4188a9804ef5cf7a83cd7644f
ToppCellcellseq-Epithelial-Epithelial_Glandular-Serous-Serous|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PRR4 PRB1 PRB3 PRB4 PRB2

1.16e-061844555433ba7bbab553ff668619822d1a9208e15cd59f
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-SMG_serous_secreting_cell-SMG_serous_(nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRR4 PRB1 PRB3 PRB2 CCNC

1.36e-06190455e3a07dcffb75375693738bef1668353f4cdba5d7
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-SMG_serous_secreting_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRR4 PRB1 PRB3 PRB2 CCNC

1.36e-06190455f6f8451eef5a387b0a1fd2e90ab965928ea2ea82
ToppCell3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_tracheobronchial_serous_cell-SMG_serous_(bronchial)-SMG_serous_(bronchial)_L.0.6.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRR4 PRB1 PRB3 PRB4 PRB2

1.39e-0619145513460059a0c1ed9f476cef28b8ad4c06349056c6
ToppCellcellseq-Epithelial-Epithelial_Glandular|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PRR4 PRB1 PRB3 PRB4 PRB2

1.50e-06194455d0fb1ff5cf0738881e114a58f0b27489f781d72b
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

PRR4 PRB1 PRB3 PRB4 PRB2

1.50e-06194455e90f6717e3421f8978d1fc1b2f30dcf69f6fcce7
ToppCell3'-Broncho-tracheal_SMG-Epithelial|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRR4 PRB1 PRB3 PRB4 PRB2

1.50e-06194455f1d057c4bf57e75ad5a821e5f3de335dbff69062
ToppCell3'-Broncho-tracheal_SMG|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRR4 PRB1 PRB3 PRB4 PRB2

1.50e-0619445542558822d7e260e7d8cf2539f1f7426e5774edfb
ToppCell3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRR4 PRB1 PRB3 PRB4 PRB2

1.50e-061944550d97dee07846416c77a861994912a9207f29ceb3
ToppCellproximal-Epithelial-Serous|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PRR4 PRB1 PRB3 PRB4 PRB2

1.54e-06195455cb62f04f0e45bfb36eed2e7a3fc54d6d390b2ed1
ToppCellproximal-Epithelial-Serous-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PRR4 PRB1 PRB3 PRB4 PRB2

1.54e-0619545506b73abc1f32543f2a51db52dc6424a2a398fe0f
ToppCellproximal-3-Epithelial-Serous|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PRR4 PRB1 PRB3 PRB4 PRB2

1.54e-0619545524a6a566143b04e37ad002e4c55037a0460ac2ef
ToppCellcellseq2|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PRR4 PRB1 PRB3 PRB4 PRB2

1.58e-06196455d9e1b8386817a668eca90288b6d0e20be4138bf8
ToppCellcellseq2-Epithelial-Epithelial_Glandular-Serous-Serous|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PRR4 PRB1 PRB3 PRB4 PRB2

1.62e-0619745540bd7c314ff5254d87737822078e7b9eaf23edf3
ToppCellBronchial-10x5prime-Epithelial-Epi_submucosal-gland|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PRR4 PRB1 PRB3 PRB4 PRB2

1.62e-06197455e2c820c4e4a6cd01ceb020473286e3f5d4e3718e
ToppCellBronchial-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Serous|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PRR4 PRB1 PRB3 PRB4 PRB2

1.62e-0619745592a66e3b5ddc3d55527c31e0d9cff15c2203ecfc
ToppCellcellseq2-Epithelial-Epithelial_Glandular-Serous|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PRR4 PRB1 PRB3 PRB4 PRB2

1.62e-06197455d3539607d5477f5dfd85f1fa99b74677c0fa8937
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_T_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PRR4 PRB1 PRB3 PRB4 PRB2

1.66e-06198455162881a04a981741a0e26e32e0c3c694282701c6
ToppCellTracheal-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Serous|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PRR4 PRB1 PRB3 PRB4 PRB2

1.75e-06200455e9908b6cba21a59023cf8d0f98fbd1d1f7de6b44
ToppCellTCGA-Head_and_Esophagus-Solid_Tissue_Normal-Head_and_Neck-Head_and_Neck_normal_tissue-5|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

PRR4 PRB1 PRB3 PRB4

2.72e-051724546b8a8d3b97c10b9d092307eed3cacbd2745df185
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1A MB21D2 NKD2 GPR179

2.91e-0517545496219e58dcb327fd27190be78193e7a0d611e62b
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1A MB21D2 NKD2 GPR179

2.91e-05175454cb974fbebe8cb58c7d3f7defabb4e056f2fee5fa
ToppCellfacs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FRS3 COL13A1 GLE1 ZFR2

3.25e-05180454d33bb00f2b7d07dda9015cb8eafd742c2b2e9ace
ToppCell3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_tracheobronchial_serous_cell-SMG_serous_(bronchial)-SMG_serous_(bronchial)_L.0.6.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRR4 PRB3 PRB4 CCNC

4.35e-05194454a8238f312a973cadf6eb29c1e02ba898c0a20412
ToppCellTracheal-10x5prime-Epithelial-Epi_submucosal-gland|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PRR4 PRB1 PRB3 PRB4

4.89e-05200454a3e044468de437948b63c517e0a4773cc247c906
ToppCellLA-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

FHDC1 COL13A1 ZNF598

9.67e-05884537232b13a9788f89600411222c0d93bdc3788816f
ToppCell390C-Epithelial_cells-Epithelial-A_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

BSN NKD2 PLEKHO1

1.33e-0498453cb0941481aef9068d7dbce0d1b6cf125f482a98d
ToppCell390C-Epithelial_cells-Epithelial-A_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

BSN NKD2 PLEKHO1

1.33e-0498453a74fb790c135bd0d0033df3aca7b789d8b25e361
Diseasethioredoxin domain-containing protein 12 measurement

TUT4 BSN

1.49e-0339432EFO_0008298
Diseaseheel bone mineral density, urate measurement

RNF216 TTC9 ZFR2

2.38e-03182433EFO_0004531, EFO_0009270
DiseaseHbA1c measurement

ZBTB38 BSN PRB1 PLEKHO1 PRB4

2.90e-03675435EFO_0004541
Diseasepreeclampsia

ZNF831 INVS

5.81e-0378432EFO_0000668

Protein segments in the cluster

PeptideGeneStartEntry
EPPSPTQEGGPGQNA

CACNA1A

1991

O00555
RPGQQDGKEGSQPPP

CNTRL

1181

Q7Z7A1
GPAATPAQDKAGQPP

ADAMTS5

21

Q9UNA0
PPNSNGTNGEAPKCP

ADGRA3

1076

Q8IWK6
KEPPAPSQGPGGKQN

GLE1

361

Q53GS7
QPGAGAGPQEPTQTP

RAB44

751

Q7Z6P3
KPPPNSEGEQGPNGS

CCNC

261

P24863
KPQASGGQEEAPNPP

FHDC1

601

Q9C0D6
GPGNPKQSGPGELPD

PCDHA11

871

Q9Y5I1
PVGNQGQHPGKGSPP

KRBA1

481

A5PL33
SIPSPQSDGGDPNQP

MB21D2

436

Q8IYB1
PAKQENVPQEGPSGP

GPR179

1001

Q6PRD1
QPAGKPQPGPSTATG

BSN

3816

Q9UPA5
QPAGPDNKENCPVPG

TK1

196

P04183
GPGSPPVQAKQEPQG

NKD2

261

Q969F2
PPNPGPDGGKQDGEA

CRACDL

361

Q6NV74
PGSPPAPQRTQQKDG

CEP89

186

Q96ST8
GGDRPKGPQNPSSPQ

FRS3

426

O43559
QEKGSPAGPPPSQGQ

CRAMP1

641

Q96RY5
NQPPAGSNPGPESEG

EIF4G1

546

Q04637
GEQSQASIQGPPGPP

COL13A1

261

Q5TAT6
PQGPPPQGDNKSQSA

PRB2

221

P02812
SPPGKPQGPPQQEGN

PRB2

361

P02812
GNQSQGPPPHPGKPE

PRB4

86

P10163
QGGHQSQGPPPTPGK

PRB4

126

P10163
PEGPPPQGGNQSQGT

PRB4

141

P10163
SPPGKPQGPPQQEGN

PRB4

241

P10163
SAKDPDKQPGPQGGP

OTP

76

Q5XKR4
DKQPGPQGGPNPSQA

OTP

81

Q5XKR4
SKQPPAGNVAQGPEP

INVS

641

Q9Y283
SKASGPPNPPAQGDG

MN1

901

Q10571
PKANGSQPNSGSPQP

TAF6

661

P49848
GSAKDGGPQPPDAPQ

PLEKHN1

536

Q494U1
EPQQGGISGPSSPQP

RNF216

221

Q9NWF9
GPQDGNQQPAPPEKV

PLEKHO1

11

Q53GL0
GKPEGPPPQGGNQSQ

PRB3

76

Q04118
PGKPEGQPPQGGNQS

PRB3

96

Q04118
KPEGPPPQGGNQSQG

PRB3

161

Q04118
GKPEGPPPQGGNQSQ

PRB3

181

Q04118
EGSPSQGGNKPQGPP

PRB3

226

Q04118
GKPQGPPPQGDKSQS

PRB1

136

P04280
QGPPPQGDKSRSPQS

PRB1

261

P04280
ARQPGQGSPTPDNDP

ZC3H6

1151

P61129
PAQPKLEGPGAPTQG

ZFR2

421

Q9UPR6
SQGVEGPPQEKGPGS

RNF25

391

Q96BH1
AEAPPNQKGPSGVQP

ARHGAP31

1016

Q2M1Z3
PRPPGDSGNQDDGPQ

PRR4

56

Q16378
QGEGPGPKETSTNGP

ZNF598

396

Q86UK7
PQSPGPGKAGDAPNR

TXNRD3

6

Q86VQ6
NKNPGPTLELQDGPG

USP30

371

Q70CQ3
TQPGVGPGPAPQNSN

PLAC8

11

Q9NZF1
PQGNDPEPSGDSPLG

ZBTB38

876

Q8NAP3
QPEGPGPTQVGKPAA

ZNF831

96

Q5JPB2
GSQPKLGPPQQGAQP

TUT4

1451

Q5TAX3
KGNPSPPAAGEGQRP

TTC9

11

Q92623