Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane transporter activity	ATP5PB SLC26A3 SLC36A4 ATP13A1 SLC26A4 TMEM175 SLC35A1 GRIA1 SLC10A3 SLC18B1 SLC26A1 SLC16A12 RYR1 RHD SLC30A6 CUL5 CNNM3 CNNM1 ATP2C1 SCNN1A KCNMA1 SLC28A1 UQCRFS1 MCUB SLC23A1 SLC35A5	1.09e-07	1180	137	26	GO:0022857
GeneOntologyMolecularFunction	transporter activity	ATP5PB SLC26A3 SLC36A4 ATP13A1 SLC26A4 TMEM175 SLC35A1 GRIA1 SLC10A3 SLC18B1 SLC26A1 SLC16A12 RYR1 RHD SLC30A6 CUL5 CNNM3 CNNM1 ATP2C1 SCNN1A KCNMA1 SLC28A1 UQCRFS1 MCUB SLC23A1 SLC35A5	6.02e-07	1289	137	26	GO:0005215
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC26A3 SLC36A4 SLC26A4 SLC35A1 SLC10A3 SLC18B1 SLC26A1 SLC16A12 SLC30A6 SLC28A1 SLC23A1 SLC35A5	9.63e-07	296	137	12	GO:0015291
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC26A3 SLC36A4 ATP13A1 SLC26A4 SLC35A1 SLC10A3 SLC18B1 SLC26A1 SLC16A12 SLC30A6 ATP2C1 SLC28A1 UQCRFS1 SLC23A1 SLC35A5	1.02e-06	477	137	15	GO:0022804
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	ATP5PB SLC26A3 ATP13A1 SLC26A4 TMEM175 GRIA1 SLC10A3 SLC18B1 SLC26A1 RYR1 RHD SLC30A6 CUL5 ATP2C1 SCNN1A KCNMA1 SLC28A1 UQCRFS1 SLC23A1	1.06e-06	758	137	19	GO:0015318
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	ATP5PB SLC26A3 ATP13A1 SLC26A4 TMEM175 GRIA1 SLC10A3 SLC18B1 SLC26A1 RYR1 SLC30A6 CUL5 ATP2C1 SCNN1A KCNMA1 SLC28A1 UQCRFS1 MCUB SLC23A1	2.07e-06	793	137	19	GO:0015075
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	ATP5PB ATP13A1 TMEM175 GRIA1 SLC10A3 SLC18B1 RYR1 RHD SLC30A6 CUL5 ATP2C1 SCNN1A KCNMA1 SLC28A1 UQCRFS1 SLC23A1	6.47e-06	627	137	16	GO:0022890
GeneOntologyMolecularFunction	olfactory receptor activity	OR8J3 OR2AK2 OR2M5 OR51J1 OR52N1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 OR52L2P OR52N4 OR2V2	8.72e-06	431	137	13	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR8J3 OR2AK2 HTR7 MC3R OR2M5 GRM6 OR51J1 OR52N1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 ADRB3 OR52L2P OR52N4 OR2V2 ADGRE1	3.53e-05	884	137	18	GO:0004930
GeneOntologyMolecularFunction	oxalate transmembrane transporter activity	SLC26A3 SLC26A4 SLC26A1	3.66e-05	10	137	3	GO:0019531
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC26A3 ATP13A1 SLC26A4 SLC10A3 SLC18B1 SLC30A6 ATP2C1 SLC28A1 UQCRFS1 SLC23A1	4.43e-05	301	137	10	GO:0022853
GeneOntologyMolecularFunction	antiporter activity	SLC26A3 SLC26A4 SLC35A1 SLC18B1 SLC26A1 SLC30A6 SLC35A5	4.71e-05	138	137	7	GO:0015297
GeneOntologyMolecularFunction	secondary active sulfate transmembrane transporter activity	SLC26A3 SLC26A4 SLC26A1	5.01e-05	11	137	3	GO:0008271
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	ATP5PB ATP13A1 TMEM175 GRIA1 SLC10A3 SLC18B1 RYR1 SLC30A6 CUL5 ATP2C1 SCNN1A KCNMA1 SLC28A1 UQCRFS1 SLC23A1	5.23e-05	664	137	15	GO:0008324
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	ATP13A1 TMEM175 GRIA1 SLC10A3 RYR1 SLC30A6 CUL5 ATP2C1 SCNN1A KCNMA1 SLC28A1 SLC23A1	8.85e-05	465	137	12	GO:0046873
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	SLC26A3 SLC36A4 SLC26A4 GRIA1 SLC10A3 SLC26A1 SLC16A12 SLC23A1	9.28e-05	207	137	8	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	SLC26A3 SLC36A4 SLC26A4 GRIA1 SLC10A3 SLC26A1 SLC16A12 SLC23A1	9.60e-05	208	137	8	GO:0005342
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR8J3 OR2AK2 HTR7 MC3R GRIA1 OR2M5 GRM6 OR51J1 OR52N1 OR10G4 OR51G2 OR51E2 TGFBR3 OR52I1 OR51D1 PTPRB ADRB3 PTPRK OR52L2P OR52N4 OR2V2 ADGRE1	1.33e-04	1353	137	22	GO:0004888
GeneOntologyMolecularFunction	sulfate transmembrane transporter activity	SLC26A3 SLC26A4 SLC26A1	1.66e-04	16	137	3	GO:0015116
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC26A3 SLC36A4 SLC26A4 SLC35A1 GRIA1 SLC10A3 SLC26A1 SLC16A12 SLC23A1	1.94e-04	293	137	9	GO:0008514
GeneOntologyMolecularFunction	nuclear receptor activity	NR4A2 OR51E2 RORA NR1D2	7.68e-04	60	137	4	GO:0004879
GeneOntologyMolecularFunction	ligand-activated transcription factor activity	NR4A2 OR51E2 RORA NR1D2	8.17e-04	61	137	4	GO:0098531
GeneOntologyMolecularFunction	dicarboxylic acid transmembrane transporter activity	SLC26A3 SLC26A4 SLC26A1	1.23e-03	31	137	3	GO:0005310
GeneOntologyMolecularFunction	bicarbonate transmembrane transporter activity	SLC26A3 SLC26A4 SLC26A1	1.35e-03	32	137	3	GO:0015106
GeneOntologyMolecularFunction	solute:inorganic anion antiporter activity	SLC26A3 SLC26A4 SLC26A1	1.35e-03	32	137	3	GO:0005452
GeneOntologyMolecularFunction	manganese ion transmembrane transporter activity	ATP13A1 ATP2C1	2.03e-03	10	137	2	GO:0005384
GeneOntologyMolecularFunction	nucleobase transmembrane transporter activity	SLC28A1 SLC23A1	2.47e-03	11	137	2	GO:0015205
GeneOntologyMolecularFunction	pyrimidine nucleotide-sugar transmembrane transporter activity	SLC35A1 SLC35A5	2.47e-03	11	137	2	GO:0015165
GeneOntologyBiologicalProcess	monoatomic ion homeostasis	DMXL2 SLC26A3 ATP13A1 SLC26A4 TMEM175 MC3R GRIA1 RYR1 RHD CUL5 CNNM3 CNNM1 OTC ATP2C1 CST5 SCNN1A KCNMA1 MCUB WNK4	2.53e-07	717	136	19	GO:0050801
GeneOntologyBiologicalProcess	monoatomic cation homeostasis	DMXL2 SLC26A3 ATP13A1 SLC26A4 TMEM175 MC3R GRIA1 RYR1 RHD CUL5 CNNM3 CNNM1 ATP2C1 CST5 SCNN1A KCNMA1 MCUB WNK4	9.19e-07	705	136	18	GO:0055080
GeneOntologyBiologicalProcess	sensory perception	DMXL2 OR8J3 OR2AK2 HTR7 MYO9A DNAJC19 SLC26A4 OR2M5 GRM6 OR51J1 OR52N1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 OR52L2P OR52N4 SCNN1A CEACAM16 KCNMA1 OR2V2	2.00e-06	1072	136	22	GO:0007600
GeneOntologyBiologicalProcess	sensory perception of smell	DMXL2 OR8J3 OR2AK2 OR2M5 OR51J1 OR52N1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 OR52L2P OR52N4 OR2V2	2.50e-06	465	136	14	GO:0007608
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	DMXL2 OR8J3 OR2AK2 OR2M5 OR51J1 OR52N1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 OR52L2P OR52N4 SCNN1A OR2V2	3.37e-06	547	136	15	GO:0007606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR8J3 OR2AK2 OR2M5 OR51J1 OR52N1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 OR52L2P OR52N4 OR2V2	5.85e-06	432	136	13	GO:0050911
GeneOntologyBiologicalProcess	chemical homeostasis	TLCD3B DMXL2 SLC26A3 ATP13A1 SLC26A4 TMEM175 MC3R GRIA1 RYR1 RHD CUL5 CNNM3 CNNM1 OTC ATP2C1 CST5 SCNN1A KCNMA1 RORA MCUB WNK4 SOAT1 NR1D2	6.92e-06	1249	136	23	GO:0048878
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR8J3 OR2AK2 HTR7 OR2M5 GRM6 OR51J1 OR52N1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 OR52L2P OR52N4 OR2V2	7.12e-06	582	136	15	GO:0050906
GeneOntologyBiologicalProcess	inorganic ion homeostasis	ATP13A1 MC3R GRIA1 RYR1 RHD CUL5 CNNM3 CNNM1 OTC ATP2C1 CST5 SCNN1A KCNMA1 MCUB WNK4	1.56e-05	622	136	15	GO:0098771
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR8J3 OR2AK2 OR2M5 OR51J1 OR52N1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 OR52L2P OR52N4 OR2V2	2.00e-05	485	136	13	GO:0050907
GeneOntologyBiologicalProcess	monoatomic ion transport	ATP5PB SLC26A3 HTR7 ATP13A1 SLC26A4 TMEM175 GRIA1 DNM1L GRM6 SLC18B1 SLC26A1 RYR1 SLC30A6 CUL5 CNNM3 CNNM1 ATP2C1 SCNN1A KCNMA1 UQCRFS1 MCUB SLC23A1 WNK4	3.18e-05	1374	136	23	GO:0006811
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	ATP5PB SLC26A3 ATP13A1 SLC26A4 TMEM175 GRM6 SLC18B1 SLC26A1 RYR1 RHD SLC30A6 CUL5 ATP2C1 SCNN1A KCNMA1 UQCRFS1 MCUB SLC23A1 WNK4	3.94e-05	1017	136	19	GO:0098660
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR8J3 OR2AK2 OR2M5 OR51J1 OR52N1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 OR52L2P OR52N4 OR2V2	4.45e-05	524	136	13	GO:0009593
GeneOntologyBiologicalProcess	oxalate transport	SLC26A3 SLC26A4 SLC26A1	5.91e-05	12	136	3	GO:0019532
GeneOntologyBiologicalProcess	detection of stimulus	OR8J3 OR2AK2 HTR7 OR2M5 GRM6 OR51J1 OR52N1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 OR52L2P OR52N4 OR2V2	8.56e-05	722	136	15	GO:0051606
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	ATP5PB SLC26A3 ATP13A1 SLC26A4 TMEM175 GRIA1 GRM6 SLC18B1 SLC26A1 RYR1 SLC30A6 CUL5 ATP2C1 SCNN1A KCNMA1 UQCRFS1 MCUB SLC23A1 WNK4	1.33e-04	1115	136	19	GO:0034220
GeneOntologyBiologicalProcess	sulfate transmembrane transport	SLC26A3 SLC26A4 SLC26A1	1.47e-04	16	136	3	GO:1902358
GeneOntologyCellularComponent	endoplasmic reticulum membrane	TLCD3B AMFR PIGK ATP13A1 COPE DAD1 POR RTN3 GRIA1 DNM1L OR2M5 GRM6 RYR1 AREG GDPD5 PIGC CHPT1 TMEM259 SGPL1 REEP4 SOAT1 RNF26	3.48e-05	1293	137	22	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	TLCD3B AMFR PIGK ATP13A1 COPE DAD1 POR RTN3 GRIA1 DNM1L OR2M5 GRM6 RYR1 AREG GDPD5 PIGC CHPT1 TMEM259 SGPL1 REEP4 SOAT1 RNF26	3.73e-05	1299	137	22	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	TLCD3B AMFR PIGK ATP13A1 COPE DAD1 POR RTN3 GRIA1 DNM1L OR2M5 GRM6 RYR1 AREG GDPD5 PIGC CHPT1 TMEM259 SGPL1 REEP4 SOAT1 RNF26	5.13e-05	1327	137	22	GO:0042175
Domain	S04_transporter_CS	SLC26A3 SLC26A4 SLC26A1	1.18e-05	7	132	3	IPR018045
Domain	SLC26A	SLC26A3 SLC26A4 SLC26A1	3.99e-05	10	132	3	PS01130
Domain	STAS	SLC26A3 SLC26A4 SLC26A1	5.46e-05	11	132	3	PS50801
Domain	STAS	SLC26A3 SLC26A4 SLC26A1	5.46e-05	11	132	3	PF01740
Domain	SLC26A/SulP_fam	SLC26A3 SLC26A4 SLC26A1	5.46e-05	11	132	3	IPR001902
Domain	STAS_dom	SLC26A3 SLC26A4 SLC26A1	5.46e-05	11	132	3	IPR002645
Domain	SLC26A/SulP_dom	SLC26A3 SLC26A4 SLC26A1	5.46e-05	11	132	3	IPR011547
Domain	-	SLC26A3 SLC26A4 SLC26A1	5.46e-05	11	132	3	3.30.750.24
Domain	Sulfate_transp	SLC26A3 SLC26A4 SLC26A1	5.46e-05	11	132	3	PF00916
Domain	Olfact_rcpt	OR8J3 OR2AK2 OR2M5 OR52N1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 OR52N4 OR2V2	1.11e-04	393	132	11	IPR000725
Domain	HEAT_REPEAT	CAND1 CLASP1 PPP4R4 HEATR6 MROH7	1.37e-04	70	132	5	PS50077
Domain	GPCR_Rhodpsn_7TM	OR8J3 OR2AK2 HTR7 MC3R OR2M5 OR52N1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 ADRB3 OR52N4 OR2V2	2.82e-04	670	132	14	IPR017452
Domain	DUF21	CNNM3 CNNM1	2.95e-04	4	132	2	IPR002550
Domain	DUF21	CNNM3 CNNM1	2.95e-04	4	132	2	PF01595
Domain	7tm_1	OR8J3 OR2AK2 HTR7 MC3R OR2M5 OR52N1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 ADRB3 OR52N4 OR2V2	3.13e-04	677	132	14	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR8J3 OR2AK2 HTR7 MC3R OR2M5 OR52N1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 ADRB3 OR52N4 OR2V2	3.53e-04	685	132	14	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR8J3 OR2AK2 HTR7 MC3R OR2M5 OR52N1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 ADRB3 OR52N4 OR2V2	3.85e-04	691	132	14	PS50262
Domain	GPCR_Rhodpsn	OR8J3 OR2AK2 HTR7 MC3R OR2M5 OR52N1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 ADRB3 OR52N4 OR2V2	3.91e-04	692	132	14	IPR000276
Domain	Nuc_sug_transp	SLC35A1 SLC35A5	4.89e-04	5	132	2	PF04142
Domain	Nuc_sug_transpt	SLC35A1 SLC35A5	4.89e-04	5	132	2	IPR007271
Domain	Melcrt_ACTH_rcpt	HTR7 MC3R	7.30e-04	6	132	2	IPR001671
Domain	ConA-like_dom	MID2 TRIML2 NBEA RYR1 MEP1B BTN2A2 PTPRK	9.46e-04	219	132	7	IPR013320
Domain	Metallophos	TMPPE MRE11 ACP5	9.93e-04	28	132	3	PF00149
Domain	Calcineurin-like_PHP_ApaH	TMPPE MRE11 ACP5	9.93e-04	28	132	3	IPR004843
Domain	Metallo-depent_PP-like	TMPPE MRE11 ACP5	1.22e-03	30	132	3	IPR029052
Domain	-	TMPPE MRE11 ACP5	1.22e-03	30	132	3	3.60.21.10
Pathway	REACTOME_MULTIFUNCTIONAL_ANION_EXCHANGERS	SLC26A3 SLC26A4 SLC26A1	3.36e-05	9	106	3	M27344
Pathway	REACTOME_MULTIFUNCTIONAL_ANION_EXCHANGERS	SLC26A3 SLC26A4 SLC26A1	3.36e-05	9	106	3	MM15084
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR8J3 OR2AK2 OR2M5 OR51J1 OR52N1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 OR52N4 OR2V2	6.84e-05	417	106	12	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR8J3 OR2AK2 OR2M5 OR52N1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 OR52N4 OR2V2	1.63e-04	389	106	11	M14091
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	ATP5PB DMXL2 CAND1 CLASP1 KALRN MYO9A KIAA1549 POR RTN3 GRIA1 DNM1L NBEA CUL5 SYNJ1 MTHFD1 SGPL1 NISCH DOCK7 PRKAR1A MACF1 TLN2 UQCRFS1	4.60e-08	1431	137	22	37142655
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	MRE11 CAND1 ATP13A1 DNAJC19 ACAD9 DHX38 SLC35A1 DNM1L PPP4R4 IWS1 CUL5 CNNM3 SCAF1 ATP2C1 PIGC UBR5 SGPL1 PRKAR1A REEP4 SLC23A1 SOAT1	5.94e-08	1327	137	21	32694731
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR8J3 OR2AK2 OR2M5 OR51J1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 OR52N4 OR2V2	1.17e-07	340	137	11	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR8J3 OR2AK2 OR2M5 OR51J1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 OR52N4 OR2V2	1.17e-07	340	137	11	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR8J3 OR2AK2 OR2M5 OR51J1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 OR52N4 OR2V2	1.28e-07	343	137	11	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR8J3 OR2AK2 OR2M5 OR51J1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 OR52N4 OR2V2	1.40e-07	346	137	11	14611657
Pubmed	Defining the membrane proteome of NK cells.	ATP5PB AMFR CAND1 ABI3 CLASP1 PIGK ATP13A1 DHX38 DAD1 POR DNM1L CHD4 CNNM3 ATP2C1 UBR5 MTHFD1 NISCH IGHMBP2 PRKAR1A	1.78e-07	1168	137	19	19946888
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	DMXL2 CAND1 KALRN GRIA1 DNM1L NBEA SYNJ1 UBR5 MACF1 TLN2	1.88e-07	281	137	10	28706196
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DMXL2 CAND1 CLASP1 KALRN GRIA1 DNM1L NBEA CHD4 SYNJ1 UBR5 TMEM259 NISCH DOCK7 KCNMA1 PRKAR1A MACF1 TLN2	2.70e-07	963	137	17	28671696
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	MRE11 AMFR PIGK ATP13A1 DNAJC19 ACAD9 CAPN1 DAD1 POR ATP2C1 HEATR6 CHPT1 UBR5 IGHMBP2 PRKAR1A	3.22e-07	754	137	15	33060197
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	ATP5PB AMFR CAND1 PIGK COPE DAD1 RTN3 CHD4 MTX2 CHPT1 UBR5 TMEM259 PRKAR1A SOAT1	3.60e-07	657	137	14	36180527
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	VEZT ATP13A1 ACAD9 POR RTN3 SLC30A6 CNNM3 ATP2C1 TMEM259 SGPL1 REEP4 SOAT1	3.73e-07	468	137	12	31056421
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	MRE11 CAND1 CLASP1 PIGK ATP13A1 ACAD9 DHX38 AHDC1 FBXL6 SLC30A6 IWS1 MRM3 SCAF1 MTHFD1 SGPL1 IGHMBP2 PRKAR1A MACF1 UQCRFS1 REEP4 SON	4.35e-07	1497	137	21	31527615
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	ATP5PB DMXL2 KALRN VEZT ATP13A1 POR RTN3 GRIA1 NBEA MCCC1 ATP2C1 SYNJ1 MTHFD1 IGHMBP2 DOCK7 PRKAR1A MACF1 TLN2	5.86e-07	1139	137	18	36417873
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	DMXL2 CAND1 KALRN GRIA1 NBEA SYNJ1 UBR5 MACF1 TLN2	7.39e-07	251	137	9	27507650
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	CLASP1 CHPT1 SYNJ1 PTPRK KCNMA1 MACF1 DOP1A	8.02e-07	128	137	7	30995482
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	DMXL2 VEZT PIGK POR RTN3 NBEA SLC30A6 VPS13D SGPL1 NISCH REEP4 SOAT1	8.14e-07	504	137	12	34432599
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	ATP5PB AMFR CAND1 VEZT ATP13A1 ACAD9 DAD1 POR RTN3 CNNM3 ATP2C1 MTX2 PTPRK UBR5 TMEM259 NISCH	1.03e-06	942	137	16	31073040
Pubmed	Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger.	SLC26A3 SLC26A4 SLC26A1	1.19e-06	6	137	3	11087667
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	CLASP1 MYO9A KIAA1549 GRIA1 DNM1L MCCC1 MTX2 UBR5 MTHFD1 SGPL1 MACF1	1.19e-06	430	137	11	32581705
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	ATP5PB DMXL2 VEZT ATP13A1 DNAJC19 ACAD9 COPE KIAA1549 POR RTN3 CEP192 CNNM3 MTX2 UBR5 ZNF644 NISCH PRKAR1A MACF1 REEP4 SOAT1	1.61e-06	1487	137	20	33957083
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CLASP1 MYO9A ARHGAP17 DNM1L CEP192 MCCC1 LARP1B PPP4R4 VPS13D SYNJ1 DOCK7 MACF1 REEP4 WNK4 DOP1A	1.68e-06	861	137	15	36931259
Pubmed	The human olfactory receptor gene family.	OR8J3 OR2AK2 OR2M5 OR52N1 OR10G4 OR51G2 OR51E2 OR52I1 OR51D1 OR52L2P OR52N4 OR2V2	1.70e-06	541	137	12	14983052
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	CLASP1 MYO9A CEP192 LARP1B VPS13D UBR5 DOCK7 MACF1	1.91e-06	209	137	8	36779422
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	AMFR CLASP1 COPE ARHGAP17 NBEA CUL5 UBR5 DOCK7 SON	2.30e-06	288	137	9	23383273
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	ABI3 ATP13A1 TMEM175 SLC35A1 RTN3 SLC18B1 SCAF1 GTF2B ATP2C1 CHPT1 TMEM259 NISCH UQCRFS1	4.14e-06	697	137	13	28298427
Pubmed	Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.	AMFR ATP13A1 COPE SLC30A6 MTX2 TMEM259 SOAT1 RNF26	4.56e-06	235	137	8	32614325
Pubmed	Physiological roles and regulation of mammalian sulfate transporters.	SLC26A3 SLC26A4 SLC26A1	4.94e-06	9	137	3	11581495
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CAND1 MID2 VEZT MYO9A CAPN1 RTN3 CEP192 SMOC2 AHDC1 PPP4R4 CUL5 OR51E2 ZBTB46 ATP2C1 PTPRB SCNN1A KCNMA1 MACF1 DOP1A	6.41e-06	1489	137	19	28611215
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	ATP5PB VEZT ACAD9 COPE POR RTN3 DNM1L LARP1B SLC30A6 MRM3 OTC VPS13D MTX2 ZNF644 NISCH UQCRFS1 MCUB SOAT1 SON	6.85e-06	1496	137	19	32877691
Pubmed	N-glycosylation and topology of the human SLC26 family of anion transport membrane proteins.	SLC26A3 SLC26A4 SLC26A1	7.03e-06	10	137	3	24647542
Pubmed	Genetic dissection of sodium and potassium transport along the aldosterone-sensitive distal nephron: importance in the control of blood pressure and hypertension.	SLC26A4 SCNN1A WNK4	1.28e-05	12	137	3	23684652
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	ATP5PB MRE11 CAND1 ATP13A1 ACAD9 COPE DHX38 POR RTN3 DNM1L CHD4 MRM3 SCAF1 MTHFD1 DOCK7 PRKAR1A TLN2 SOAT1	1.32e-05	1425	137	18	30948266
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	CAND1 COPE POR DNM1L NBEA CHD4 CEP192 MCCC1 SLC30A6 CNNM3 UBR5 MTHFD1 DOCK7	1.32e-05	777	137	13	35844135
Pubmed	Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance.	DNM1L VPS13D	1.54e-05	2	137	2	29307555
Pubmed	Reduced ENaC protein abundance contributes to the lower blood pressure observed in pendrin-null mice.	SLC26A4 SCNN1A	1.54e-05	2	137	2	17686956
Pubmed	WNK4 kinase inhibits Maxi K channel activity by a kinase-dependent mechanism.	KCNMA1 WNK4	1.54e-05	2	137	2	21613417
Pubmed	Voltage-dependent Ca2+ channels, not ryanodine receptors, activate Ca2+-dependent BK potassium channels in human retinal pigment epithelial cells.	RYR1 KCNMA1	1.54e-05	2	137	2	19096717
Pubmed	Pendrin modulates ENaC function by changing luminal HCO3-.	SLC26A4 SCNN1A	1.54e-05	2	137	2	20966128
Pubmed	RORα and REV-ERBα are Associated With Clinicopathological Parameters and are Independent Biomarkers of Prognosis in Gastric Cancer.	RORA NR1D2	1.54e-05	2	137	2	34931925
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	MRE11 VEZT ATP13A1 POR DNM1L SLC30A6 VPS13D PIGC UBR5 REEP4 SOAT1	1.66e-05	568	137	11	37774976
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	CLASP1 MYO9A DHX38 RTN3 ARHGAP17 CEP192 MCCC1 SYNJ1 UBR5 ZNF644 MACF1	2.28e-05	588	137	11	38580884
Pubmed	ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis.	ATP5PB AMFR VEZT COPE POR RTN3 REEP4 SOAT1	2.60e-05	299	137	8	37931956
Pubmed	Evolutionarily conserved regulators of tau identify targets for new therapies.	AMFR ATP13A1 DAD1 POR SLC30A6 CNNM3 ATP2C1 MTHFD1 SGPL1 SOAT1	4.05e-05	516	137	10	36610398
Pubmed	A protein interaction landscape of breast cancer.	CAND1 ACAD9 AREG FBXW8 ATP2C1 HEATR6 MTX2 UBR5 SGPL1 MACF1 UQCRFS1	4.51e-05	634	137	11	34591612
Pubmed	Claudin-7 Modulates Cl- and Na+ Homeostasis and WNK4 Expression in Renal Collecting Duct Cells.	SCNN1A WNK4	4.61e-05	3	137	2	31382627
Pubmed	Molecular analysis of human solute carrier SLC26 anion transporter disease-causing mutations using 3-dimensional homology modeling.	SLC26A3 SLC26A4	4.61e-05	3	137	2	28941661
Pubmed	Pendrin gene ablation alters ENaC subcellular distribution and open probability.	SLC26A4 SCNN1A	4.61e-05	3	137	2	25972513
Pubmed	Association of ZNF644, GRM6, and CTNND2 genes with high myopia in the Han Chinese population: Jiangsu Eye Study.	GRM6 ZNF644	4.61e-05	3	137	2	27034204
Pubmed	Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator.	RORA NR1D2	4.61e-05	3	137	2	7838156
Pubmed	The non-diuretic hypotensive effects of thiazides are enhanced during volume depletion states.	SLC26A4 KCNMA1	4.61e-05	3	137	2	28719636
Pubmed	Newborn genetic screening for high risk deafness-associated mutations with a new Tetra-primer ARMS PCR kit.	SLC26A4 SLC26A1	4.61e-05	3	137	2	23815884
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DMXL2 CAND1 KALRN ATP13A1 NR4A2 DAD1 NBEA CHD4 HEATR6 SYNJ1 PTPRK NISCH PRKAR1A MACF1 TLN2 NR1D2	4.89e-05	1285	137	16	35914814
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	VEZT COPE DHX38 KIAA1549 POR NBEA CEP192 PPP4R4 IWS1 CNNM3 CNNM1 PTPRB PTPRK KCNMA1	7.19e-05	1049	137	14	27880917
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	AMFR CLASP1 PIGK DAD1 POR RTN3 CHD4 ATP2C1 PTPRK SGPL1 ZNF644 DOCK7 REEP4 MCUB SOAT1	8.40e-05	1203	137	15	29180619
Pubmed	Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum.	AMFR RTN3 REEP4	8.72e-05	22	137	3	37225996
Pubmed	Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins.	PIGK PIGC	9.19e-05	4	137	2	12655644
Pubmed	Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism.	CAPN1 SGPL1	9.19e-05	4	137	2	21331079
Pubmed	ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4PHAII mice.	SCNN1A WNK4	9.19e-05	4	137	2	28365586
Pubmed	Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP).	CNNM3 CNNM1	9.19e-05	4	137	2	12657465
Pubmed	Molecular cloning and characterization of the mouse Acdp gene family.	CNNM3 CNNM1	9.19e-05	4	137	2	14723793
Pubmed	Purification, crystallization and preliminary crystallographic analysis of the CBS pair of the human metal transporter CNNM4.	CNNM3 CNNM1	9.19e-05	4	137	2	21393841
Pubmed	Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors.	RORA NR1D2	9.19e-05	4	137	2	7838158
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	VEZT ATP13A1 KIAA1549 POR RTN3 MCCC1 SLC30A6 CNNM3 ATP2C1 MTHFD1 SGPL1 REEP4 SOAT1	1.05e-04	952	137	13	38569033
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	ATP5PB MRE11 CAND1 DNAJC19 DNM1L CHD4 PRKAR1A MACF1 TLN2 UQCRFS1 WNK4 DOP1A	1.39e-04	847	137	12	35235311
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	ATP5PB MRE11 ACAD9 COPE DNM1L CHD4 MTHFD1 SGPL1 DOCK7 MACF1	1.42e-04	601	137	10	33658012
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	ATP5PB CAND1 MID2 CNNM3 MRM3 MTHFD1 MCUB	1.43e-04	285	137	7	32838362
Pubmed	Role of CLASP2 in microtubule stabilization and the regulation of persistent motility.	CLASP1 MACF1	1.53e-04	5	137	2	17113391
Pubmed	WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination.	SCNN1A WNK4	1.53e-04	5	137	2	23594824
Pubmed	The central melanocortin system directly controls peripheral lipid metabolism.	MC3R ADRB3	1.53e-04	5	137	2	17885689
Pubmed	Genotype patterns that contribute to increased risk for or protection from developing heroin addiction.	NR4A2 GRM6	1.53e-04	5	137	2	18195715
Pubmed	GENE REGULATION. Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock.	RORA NR1D2	1.53e-04	5	137	2	26044300
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DMXL2 ATP13A1 DHX38 PPP4R4 VPS13D ATP2C1 SGPL1 MACF1 DOP1A	1.55e-04	493	137	9	15368895
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	AMFR PIGK ATP13A1 COPE TMEM175 DAD1 ATP2C1 TMEM259 SGPL1	1.70e-04	499	137	9	22810586
Pubmed	Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.	AMFR MID2 UBR5	1.82e-04	28	137	3	35474067
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	ATP5PB AMFR CAND1 PIGK ACAD9 COPE CHD4 MCCC1 IWS1 CUL5 MTX2 UBR5 TMEM259 SGPL1 DOCK7 SOAT1	1.82e-04	1440	137	16	30833792
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	MYO9A DNM1L RYR1 DOCK7 TLN2 DOP1A	1.83e-04	208	137	6	33230847
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	ATP5PB MRE11 CAND1 CHD4 CNNM3 SCAF1 FBXW8 UBR5 MTHFD1 DOCK7 PRKAR1A MACF1 SON	2.14e-04	1024	137	13	24711643
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CLASP1 CEP192 UBR5 ZNF644 NISCH DOCK7 MACF1 SON	2.21e-04	407	137	8	12693553
Pubmed	Detailed ordering of markers localizing to the Xq26-Xqter region of the human X chromosome by the use of an interspecific Mus spretus mouse cross.	SLC10A3 OTC	2.29e-04	6	137	2	2882509
Pubmed	Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9.	SLC26A3 SLC26A4	2.29e-04	6	137	2	11834742
Pubmed	Wdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activation.	ARHGAP17 RORA	2.29e-04	6	137	2	36681682
Pubmed	The circadian clock component BMAL1 is a critical regulator of p21WAF1/CIP1 expression and hepatocyte proliferation.	RORA NR1D2	2.29e-04	6	137	2	18086663
Pubmed	Expression of the metabotropic glutamate receptor mGluR1 alpha and the ionotropic glutamate receptor GluR1 in the brain during the postnatal development of normal mouse and in the cerebellum from mutant mice.	GRIA1 RORA	2.29e-04	6	137	2	8230318
Pubmed	Differential dynamics of cullin deneddylation via COP9 signalosome subunit 5 interaction.	CAND1 CUL5	2.29e-04	6	137	2	36423380
Pubmed	Response to methadone maintenance treatment is associated with the MYOCD and GRM6 genes.	NR4A2 GRM6	2.29e-04	6	137	2	20560679
Pubmed	L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.	RYR1 TGFBR3 SCNN1A KCNMA1 ADGRE1	2.65e-04	143	137	5	20424473
Pubmed	Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.	PIGK ATP13A1 ACAD9 POR IWS1 ATP2C1 UQCRFS1 SOAT1	2.82e-04	422	137	8	27342126
Pubmed	Identification of proteins interacting with the mitochondrial small heat shock protein Hsp22 of Drosophila melanogaster: Implication in mitochondrial homeostasis.	ATP5PB DNAJC19 POR MCCC1 UQCRFS1	2.91e-04	146	137	5	29509794
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	ATP5PB TMPPE CLASP1 VEZT ATP13A1 SLC35A1 DAD1 SLC18B1 AREG CNNM3 CHPT1 MTHFD1 MACF1	3.01e-04	1061	137	13	33845483
Pubmed	Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis.	ADRB3 RORA	3.19e-04	7	137	2	18694395
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	CAPN1 RYR1	3.19e-04	7	137	2	20962236
Pubmed	The corepressor N-CoR and its variants RIP13a and RIP13Delta1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70.	GTF2B NR1D2	3.19e-04	7	137	2	9611234
Pubmed	Novel human G-protein-coupled receptors.	OR52I1 OR51D1	3.19e-04	7	137	2	12732197
Pubmed	Endolymphatic Na⁺ and K⁺ concentrations during cochlear growth and enlargement in mice lacking Slc26a4/pendrin.	SLC26A4 SCNN1A	3.19e-04	7	137	2	23741519
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	MRE11 FBXW8 UBR5 ZNF644 DOCK7 SON	3.28e-04	232	137	6	25515538
Pubmed	Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.	ATP5PB CAND1 MCCC1 CFAP54 MTX2 UQCRFS1 SON	3.55e-04	331	137	7	29199018
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	ATP5PB CAND1 COPE CAPN1 RTN3 CHD4 MCCC1 RYR1 MTHFD1 MACF1 UQCRFS1	3.68e-04	807	137	11	30575818
Pubmed	Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.	CAND1 WNK4	4.25e-04	8	137	2	26286618
Pubmed	Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry.	ATP5PB DNM1L MCCC1 OTC MTX2 MTHFD1 UQCRFS1	4.39e-04	343	137	7	28130547
Interaction	TCTN3 interactions	VEZT PIGK ATP13A1 COPE DAD1 POR RTN3 SLC30A6 CHPT1 SGPL1 ZNF644 REEP4 SOAT1	2.16e-07	334	128	13	int:TCTN3
Interaction	PDHB interactions	CAND1 ACAD9 POR DNM1L FBXL6 OTC HEATR6 UBR5 KCNMA1 UQCRFS1 MCUB SOAT1	1.92e-06	342	128	12	int:PDHB
Cytoband	11p15.4	OR51J1 OR52N1 OR51G2 OR52I1 OR51D1 OR52L2P OR52N4	2.56e-06	200	137	7	11p15.4
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	OR51J1 OR52N1 OR51G2 OR51E2 OR52I1 OR51D1 OR52L2P OR52N4	3.09e-04	564	137	8	chr11p15
GeneFamily	Solute carriers	SLC26A3 SLC36A4 SLC26A4 SLC35A1 SLC10A3 SLC18B1 SLC26A1 SLC16A12 SLC30A6 SLC28A1 SLC23A1 SLC35A5	1.34e-06	395	97	12	752
GeneFamily	Olfactory receptors, family 51	OR51J1 OR51G2 OR51E2 OR51D1	8.96e-05	44	97	4	164
GeneFamily	Olfactory receptors, family 52	OR52N1 OR52I1 OR52L2P OR52N4	1.37e-04	49	97	4	165
GeneFamily	Fibronectin type III domain containing	PRTG MID2 KALRN PTPRB PTPRK	1.71e-03	160	97	5	555
GeneFamily	Nuclear hormone receptors	NR4A2 RORA NR1D2	2.31e-03	49	97	3	71
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	TMPPE PIGK ATP13A1 DAD1 POR RTN3 SLC10A3 FBXL6 SLC30A6 TGFBR3 PTPRK TMEM259 SGPL1 NISCH CST5 SOAT1 SON RNF26	2.65e-08	703	136	18	MM1055
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	TMPPE PIGK ATP13A1 DAD1 POR RTN3 SLC10A3 FBXL6 SLC30A6 TGFBR3 PTPRK TMEM259 SGPL1 NISCH SOAT1 SON RNF26	9.58e-08	681	136	17	M5314
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TMPPE HTR7 DNAJC19 NBEA SLC16A12 CNNM3 RNF26	7.40e-07	164	136	7	d8ecb3de6e34f5f574449e3d2f26fa0b2b7e84e8
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CHIT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DMXL2 ACP5 RAB42 SLC18B1 KCNMA1 LHFPL2 SOAT1	2.60e-06	198	136	7	0b41b3d6c2db795320e8b65d40d85fb8b618cc34
ToppCell	PND07-Epithelial-Epithelial_Airway-Neurosecretory-Secretory\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POR SLC16A12 SCNN1A SLC23A1 WNK4 MUC20	9.88e-06	160	136	6	028b5261a1da832d52f66fb620db83e5fbbd874a
ToppCell	PND07-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POR SLC16A12 SCNN1A SLC23A1 WNK4 MUC20	9.88e-06	160	136	6	1f4ee446436726c3d373f56d87dd80b6a12e8b9e
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage\|343B / Donor, Lineage, Cell class and subclass (all cells)	HTR7 ACP5 RAB42 ARHGAP17 KCNMA1 LHFPL2	1.14e-05	164	136	6	057ca87847373eff7fe97dd9f4358509e66ca4c3
ToppCell	droplet-Liver-Npc-21m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLCD3B TMEM204 NBEA TGFBR3 PTPRB LHFPL2	2.05e-05	182	136	6	dc55de945c6f78f32eb3a1b3520835eb8417e068
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLCD3B TMEM204 NBEA TGFBR3 PTPRB LHFPL2	2.05e-05	182	136	6	010a7364da46101cb5068891fd7bc712ea8f13bd
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLCD3B TMEM204 NBEA TGFBR3 PTPRB LHFPL2	2.05e-05	182	136	6	b1ec2015aad1181eac1bbf8d48ad6f2f7ed24a01
ToppCell	facs-Kidney-nan-3m-Epithelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP5PB CHPT1 MTHFD1 SCNN1A UQCRFS1 WNK4	2.39e-05	187	136	6	208686e6ebc9f3a774bcbe89274457ac9449f90e
ToppCell	-Unknown-Endothelial-Myofibroblast\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HTR7 MYO9A TGFBR3 UBR5 KCNMA1 LHFPL2	2.46e-05	188	136	6	6468fa95ad0395395301115286f2d8c0df5d3882
ToppCell	-Unknown-Endothelial\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HTR7 MYO9A TGFBR3 UBR5 KCNMA1 LHFPL2	2.46e-05	188	136	6	7a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell	-Unknown\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HTR7 MYO9A TGFBR3 UBR5 KCNMA1 LHFPL2	2.46e-05	188	136	6	9cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCell	droplet-Limb_Muscle-nan-3m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLASP1 TMEM204 KALRN VEZT SLFN12 CNNM3	2.54e-05	189	136	6	16a4c92dd7a0d60f3691bd3130a091a9a54730f1
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC26A4 CHD4 PTPRB MACF1 RORA SON	2.61e-05	190	136	6	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM204 NBEA SMOC2 PTPRB LHFPL2 TLN2	2.85e-05	193	136	6	2483bb7f398e4fa0ef09c8bd584ed25703853f03
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NBEA CHD4 SYNJ1 NISCH MACF1 SON	3.02e-05	195	136	6	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	Macrophages-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	ACP5 SLC35A1 RAB42 KCNMA1 LHFPL2 SOAT1	3.02e-05	195	136	6	eb104f3bb08ab9eca31273c0523a5c90de1f30a9
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_12\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ATP5PB MRE11 HTR7 AREG MTHFD1	3.12e-05	118	136	5	f0f40a0165156e3fc1584480b473b0e84e10d2cc
ToppCell	facs-Brain_Myeloid-Cortex_-18m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMFR ABI3 RTN3 PRKAR1A ADGRE1 SLC35A5	3.20e-05	197	136	6	e73ca8c8f42cbcc56eaa5fe3d69abd1ce7b7bbca
ToppCell	facs-Brain_Myeloid-Cortex_\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMFR ABI3 RTN3 PRKAR1A ADGRE1 SLC35A5	3.20e-05	197	136	6	81379fe6bd14a1ba26f4a159497262adcb600b18
ToppCell	facs-Brain_Myeloid-Cortex_-18m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMFR ABI3 RTN3 PRKAR1A ADGRE1 SLC35A5	3.20e-05	197	136	6	271c75f491d03bd248c7ec037ef02e39456f3ac0
ToppCell	facs-Brain_Myeloid-Cortex_-18m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMFR ABI3 RTN3 PRKAR1A ADGRE1 SLC35A5	3.20e-05	197	136	6	9db329c6fea532dd1afb624f4c29c92407f45568
ToppCell	facs-Brain_Myeloid-Cortex_-18m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMFR ABI3 RTN3 PRKAR1A ADGRE1 SLC35A5	3.20e-05	197	136	6	173c0c8de4e69882a9f91189deeb4a651fefe551
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_12\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ATP5PB MRE11 HTR7 AREG MTHFD1	3.25e-05	119	136	5	a6b359e7aafcc197f53eb5e19c3a905bc09497bb
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_interstitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABI3 HTR7 ATP13A1 GRM6 KCNMA1 REEP4	3.29e-05	198	136	6	9a77038e5db0ea757fd7ebcab294785b166ddc12
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	SLC26A3 CLASP1 NBEA UBR5 KCNMA1 RORA	3.39e-05	199	136	6	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Macrophage_other-Macro_CHIT1\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DMXL2 ACP5 RAB42 KCNMA1 LHFPL2 SOAT1	3.39e-05	199	136	6	54a54ad983503ed515d476882d86b17d97892037
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Macrophage_other-Macro_CHIT1\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DMXL2 ACP5 RAB42 KCNMA1 LHFPL2 SOAT1	3.39e-05	199	136	6	f987f48970aec46156b80656e49b9f3604f3758c
ToppCell	tumor_Lung-Myeloid_cells-mo-Mac\|Myeloid_cells / Location, Cell class and cell subclass	DMXL2 ACP5 RAB42 KCNMA1 LHFPL2 SOAT1	3.48e-05	200	136	6	58ff8db0ecf71daa86f9a38208e0d9b712cac0b5
ToppCell	Severe-Myeloid-Macrophages-FCN1-SPP1+\|Severe / Condition, Lineage, Cell class and cell subclass	DMXL2 ACP5 RAB42 KCNMA1 LHFPL2 SOAT1	3.48e-05	200	136	6	b8cd209b810312793465b28bb2a6cbe5d94da91f
Disease	epilepsy (biomarker_via_orthology)	CAPN1 NR4A2 GRIA1	9.56e-05	21	126	3	DOID:1826 (biomarker_via_orthology)
Disease	Developmental Academic Disorder	HTR7 POR GRIA1	2.56e-04	29	126	3	C1330966
Disease	Learning Disorders	HTR7 POR GRIA1	2.56e-04	29	126	3	C0023186
Disease	Learning Disturbance	HTR7 POR GRIA1	2.56e-04	29	126	3	C0751263
Disease	Adult Learning Disorders	HTR7 POR GRIA1	2.56e-04	29	126	3	C0751262
Disease	Learning Disabilities	HTR7 POR GRIA1	2.56e-04	29	126	3	C0751265
Disease	pseudohypoaldosteronism (is_implicated_in)	SCNN1A WNK4	4.98e-04	8	126	2	DOID:4479 (is_implicated_in)
Disease	Congenital adrenal hyperplasia	POR PRKAR1A	6.39e-04	9	126	2	C0001627
Disease	rectum cancer (is_implicated_in)	MRE11 CHD4	6.39e-04	9	126	2	DOID:1993 (is_implicated_in)
Disease	Malignant neoplasm of breast	MRE11 AMFR KALRN GRM6 AREG RHD CUL5 ZNF644 NISCH SLC28A1 MROH7 MACF1 DOP1A	7.00e-04	1074	126	13	C0006142
Disease	Pseudohypoaldosteronism, Type I	SCNN1A WNK4	7.96e-04	10	126	2	C0268436
Disease	Pseudohypoaldosteronism	SCNN1A WNK4	7.96e-04	10	126	2	C0033805
Disease	Hyperpotassemia and Hypertension, Familial	SCNN1A WNK4	7.96e-04	10	126	2	C2713447
Disease	Pseudohypoaldosteronism, Type I, Autosomal Recessive	SCNN1A WNK4	7.96e-04	10	126	2	C1449843
Disease	Pseudohypoaldosteronism, Type II	SCNN1A WNK4	7.96e-04	10	126	2	C1449844
Disease	Pseudohypoaldosteronism, Type I, Autosomal Dominant	SCNN1A WNK4	7.96e-04	10	126	2	C1449842
Disease	Autistic Disorder	NR4A2 GRIA1 NBEA CHD4 KCNMA1 RORA	9.19e-04	261	126	6	C0004352
Disease	Down syndrome (implicated_via_orthology)	SYNJ1 DOP1A	1.83e-03	15	126	2	DOID:14250 (implicated_via_orthology)
Disease	acute graft vs. host disease, donor genotype effect measurement	KALRN RORA	1.83e-03	15	126	2	EFO_0004599, EFO_0007892
Disease	vitamin C measurement	CHPT1 SLC23A1	2.09e-03	16	126	2	EFO_0600003
Disease	phospholipids:total lipids ratio, high density lipoprotein cholesterol measurement	DHX38 GFOD2 DOCK7 MACF1 RORA MCUB	2.10e-03	307	126	6	EFO_0004612, EFO_0020946
Disease	alpha-L-iduronidase measurement	TMEM175 SLC26A1	2.36e-03	17	126	2	EFO_0020139
Disease	Headache	TGFBR3 BTN2A2 MACF1	2.62e-03	64	126	3	HP_0002315
Disease	age at onset, Parkinson disease	TMEM175 LHFPL2	2.65e-03	18	126	2	EFO_0004847, MONDO_0005180
Disease	cholesterol:total lipids ratio, low density lipoprotein cholesterol measurement	AMFR DOCK7 MACF1 MCUB	3.44e-03	144	126	4	EFO_0004611, EFO_0020943
Disease	creatinine measurement	CAND1 ZBTB17 POR RYR1 AREG GTF2B ZBTB46 MTX2 DOCK7 KCNMA1 SLC23A1	3.64e-03	995	126	11	EFO_0004518

Protein segments in the cluster

Peptide	Gene	Start	Entry
MFDSTASQFLAVLEA	CFAP54	401	Q96N23
LSKIALAAIAAFMSA	AREG	196	P15514
LAAIAAFMSAVILTA	AREG	201	P15514
AFMSAVILTAVAVIT	AREG	206	P15514
AGLADMVAAAETITT	CUL5	321	Q93034
ILAVTAANTDMATSE	DNM1L	181	O00429
ASVVVKLSAAAVATM	CEACAM16	306	Q2WEN9
SVFTLSMLVAFEASL	ATP13A1	266	Q9HD20
SIEAAMVKVFSSEAA	ACAD9	376	Q9H845
SVDVTNTTFLLMAAS	COPE	111	O14579
ASDFSVQSVAISLVM	DOP1A	801	Q5JWR5
QMFLVALADTVATTS	DMXL2	1531	Q8TDJ6
SMVESTAVVSFLEEA	FBXL6	256	Q8N531
VVAAEAATVAAATMA	AHDC1	566	Q5TGY3
MTNVFVTSLAAADLV	ADRB3	71	P13945
SIDISSVLDMEAITF	CAPN1	251	P07384
ILEMFTISVSLAVAA	ATP2C1	291	P98194
SAETFTALSVLGVMV	ATP5PB	96	P24539
SLLASSFMTEVVVAL	MROH7	771	Q68CQ1
ELAASLGMAFVETSV	RAB42	146	Q8N4Z0
TFISDADDVVSAMIV	IWS1	551	Q96ST2
ISLMSSVVADFSEFE	KIAA1549	461	Q9HCM3
ALEETMAFTTQALAS	ABI3	46	Q9P2A4
MSASVVSVISRFLEE	DAD1	1	P61803
LMSFADIANTSLAIT	PTPRB	1266	P23467
LACADTSANVMVIFV	OR10G4	186	Q8NGN3
MNISDVISFDILVSA	OR2AK2	1	Q8NG84
TMILRAVVSLSSADA	OR52N4	221	Q8NGI2
AIFTADGNMISASTL	MCUB	111	Q9NWR8
TAFAVSVLDSLMSAT	KCNMA1	1036	Q12791
TVSEAVAEEVSLFSM	POR	11	P16435
NFMVLIATSVETSAA	MUC20	101	Q8N307
ALSAMLDFFQALVVT	CAND1	751	Q86VP6
DATVATASAFDVVML	FBXW8	311	Q8N3Y1
LGSMDAIIDAVATFS	OR2M5	151	A3KFT3
SAVESAVLLAMAFDR	OR51D1	121	Q8NGF3
HSTADLVLFSVVMAV	OR2V2	21	Q96R30
LSAIESTILLAMAFD	OR51E2	106	Q9H255
ESSVLLSMAFDRFVA	OR51G2	116	Q8NGK0
LAMLALAEVRVSAST	OR51J1	66	Q9H342
VTLAISMTFLSTVAA	SLC10A3	281	P09131
DTARVLSSMADAVLA	OTC	126	P00480
ALDERSTILAMSAVF	KALRN	406	O60229
VIFVADAANAILMSL	HEATR6	851	Q6AI08
AAMVATLEEFTSPAA	MACF1	1206	O94854
LSIVVAFAELIAFMS	LHFPL2	16	Q6ZUX7
ILASTVVAMSAVAQL	GDPD5	131	Q8WTR4
ISAATNLVFSMITVL	OR8J3	201	Q8NGG0
MAVTDSLSRAATVLA	PIGK	1	Q92643
TRNFTVAMATLTVLA	PRTG	311	Q2VWP7
ASASSVSIMVANVLR	GRM6	151	O15303
FMDDIAALVSTIASD	DOCK7	1041	Q96N67
SIITATMEFSALDIS	COL6A5	1881	A8TX70
KAATSVDAFRMVTAS	GFOD2	96	Q3B7J2
LLTALMVAVAGSASA	CST5	11	P28325
ALVVEMVLTFLFSAA	CRYM-AS1	26	A6NIL9
MAAASAVSVLLVAAE	MCCC1	1	Q96RQ3
MAETAAIITDASFLS	TMEM259	541	Q4ZIN3
FLCSLAVADMLVSVS	MC3R	76	P41968
SMLRISTIASAIAEA	CEP192	711	Q8TEP8
DAMFSVSFIAGETVI	PRKAR1A	151	P10644
TANLAAFLTVERMVS	GRIA1	631	P42261
VSIADADGLFMVTTA	BTN2A2	196	Q8WVV5
AAAVAVVESMVTATE	CHD4	231	Q14839
SSVLSVVEMAELVFD	SCNN1A	561	P37088
LDTATFSTTEMALAL	RYR1	2536	P21817
AVSSTVAVFALMLII	MEP1B	656	Q16820
TRTAQFDISVASEIM	MTHFD1	556	P11586
FDISVASEIMAVLAL	MTHFD1	561	P11586
TEAFDIAELRSSTIM	CDH19	651	Q9H159
LFDVSEITSAAMVHS	LARP1B	571	Q659C4
MDTTAAAALPAFVAL	PTPRK	1	Q15262
ALFMAAEIVTDIFIS	REEP4	46	Q9H6H4
FLCVLAAVDIVMASS	OR52I1	66	Q8NGK6
ATAVETGLLLTMAFD	OR52I1	111	Q8NGK6
LSMLAAIDLVVASST	OR52L2P	81	Q8NGH6
TMILQAVVSLSSADA	OR52N1	221	Q8NH53
MSLVAEAFVSQIAAA	MTX2	1	O75431
EEMSLFTAVVLVSAD	NR1D2	501	Q14995
SAFSCIAALAMVTER	NR4A2	501	P43354
MLLSLAAFSVISVVS	RTN3	866	O95197
AAAAIVLSTIASVML	SLC35A1	276	P78382
SAAMLAVFAVSAVVH	SOAT1	446	P35610
TAAMSFLTILQDESV	PPP4R4	111	Q6NUP7
LMFESGAVAVLSSAE	SYNJ1	31	O43426
AVSFAAAMTASSSIL	SLC18B1	141	Q6NT16
SFLLMSDFVVLAVSV	SLC16A12	276	Q6ZSM3
VDSLNSAMAASILLF	MRM3	386	Q9HC36
LAEMAAATSVHVVAV	ARHGAP17	416	Q68EM7
MVDVLVFASSLNFSE	NBEA	1441	Q8NFP9
AFLAHISSSAVAMAI	RNF26	186	Q9BY78
IAMVAFAVAFSVASV	SLC26A3	346	P40879
AIVSSTLSLNMAIFA	PIGC	171	Q92535
AVSASRNMSIIDAFK	MRE11	611	P49959
TTVDRNMVAELSSVF	SGPL1	531	O95470
VSLALADLSVAVAVM	HTR7	121	P34969
LATVFLESVESMTLA	ADGRE1	401	Q14246
LAFMAAESLLVTVRT	AMFR	216	Q9UKV5
DSLSTVFMAVGASIA	CHPT1	136	Q8WUD6
MRVLSTSTDLEAAVA	CLASP1	791	Q7Z460
MLRSDAVLDFATVSE	CNNM1	441	Q9NRU3
MLDASTVLDFGVLAS	CNNM3	326	Q8NE01
PAIAIATAAAAAMVS	TCERG1L	236	Q5VWI1
RLDFSAMVLAAESFT	TRIML2	286	Q8N7C3
MLSFSDALLSIIATV	TMEM175	36	Q9BSA9
FVSSMSASADVLALA	UQCRFS1	136	P47985
ATMSALSVLISVDAV	RHD	116	Q02161
VTAAAVLGMFSATLA	SLC23A1	316	Q9UHI7
FSEMLAASFSIAVVA	SLC26A4	346	O43511
AMAVIFSNFSIITTA	SLC35A5	121	Q9BS91
VAAAFSISLAEMFAR	SLC26A1	351	Q9H2B4
TEDEIALFSAFVLMS	RORA	416	P35398
ISVAAAAIYMASQAS	GTF2B	251	Q00403
AAMLESLTSANVVLA	IGHMBP2	336	P38935
ATVLDMATDSFLAGL	SCAF1	86	Q9H7N4
MATDSFLAGLVSVLD	SCAF1	91	Q9H7N4
EFLTSVLDALSTDMV	SMOC2	311	Q9H3U7
IMFVQEEALASSLSS	NISCH	511	Q9Y2I1
SFVTTTFVIEAMAAA	TMEM104	56	Q8NE00
TNVSVAIFMLDTVTL	ACP5	146	P13686
ITSAKVMNATAALEF	SLFN12	131	Q8IYM2
IVTSATMDAEKFAAF	DHX38	681	Q92620
GIDATSLIAASVMAA	SLC28A1	361	O00337
MAAAVLTDRAQVSVT	ZNF264	1	O43296
ASITETSFSLLMAEA	ZNF644	1311	Q9H582
AVDTASAIAIALMTF	SLC30A6	226	Q6NXT4
DMVTLATEALAATAV	ZBTB17	661	Q13105
MAASAQVSVTFEDVA	ZNF543	1	Q08ER8
ARLVSSVQAIMASTA	TLCD3B	41	Q71RH2
ADLDTTIMFATAGTL	TLN2	1991	Q9Y4G6
EAMAAAFQLASFVLV	TMEM204	136	Q9BSN7
LAAEVAARSLSFTTM	VEZT	741	Q9HBM0
AERVAMATASSQVLI	MID2	356	Q9UJV3
MASTVVAVGLTIAAA	DNAJC19	1	Q96DA6
LASAFSLAVMTVAQS	WNK4	926	Q96J92
SFLANVSMAVSLVII	SLC36A4	236	Q6YBV0
AMAVLESSAVTVLES	SON	1356	P18583
ALTSRNVIEVMSAAS	ZBTB46	96	Q86UZ6
VIAIFALMSSCLATA	TGFBR3	6	Q03167
SVARVFVILSVEMAS	UBR5	1431	O95071
AKATLAAVTVFVSMI	TMPPE	11	Q6ZT21
MEDAALTEALSFTFV	VPS13D	1261	Q5THJ4
AVQKDAFVMASAAAL	MYO9A	1066	B2RTY4