Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	TUDOR	PHF20L1 SMNDC1	2.45e-04	23	19	2	PS50304
Domain	TUDOR	PHF20L1 SMNDC1	3.39e-04	27	19	2	SM00333
Domain	Tudor	PHF20L1 SMNDC1	4.19e-04	30	19	2	IPR002999
Domain	DH_1	ARHGEF18 ARHGEF28	1.85e-03	63	19	2	PS00741
Domain	RhoGEF	ARHGEF18 ARHGEF28	2.15e-03	68	19	2	SM00325
Domain	DH_2	ARHGEF18 ARHGEF28	2.27e-03	70	19	2	PS50010
Domain	RhoGEF	ARHGEF18 ARHGEF28	2.27e-03	70	19	2	PF00621
Domain	-	ARHGEF18 ARHGEF28	2.34e-03	71	19	2	1.20.900.10
Domain	DH-domain	ARHGEF18 ARHGEF28	2.34e-03	71	19	2	IPR000219
Domain	Ion_trans_dom	KCNQ1 SCN8A	5.90e-03	114	19	2	IPR005821
Domain	Ion_trans	KCNQ1 SCN8A	5.90e-03	114	19	2	PF00520
Pubmed	Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells.	CFTR PDE8A	3.47e-07	2	21	2	34936285
Pubmed	AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells.	KCNQ1 CFTR	1.04e-06	3	21	2	20861072
Pubmed	Molecular mechanisms of calcium-sensing receptor-mediated calcium signaling in the modulation of epithelial ion transport and bicarbonate secretion.	KCNQ1 CFTR	1.04e-06	3	21	2	25331955
Pubmed	Behavioral audiograms of homozygous med(J) mutant mice with sodium channel deficiency and unaffected controls.	KCNQ1 SCN8A	2.08e-06	4	21	2	12204355
Pubmed	K2P TASK-2 and KCNQ1-KCNE3 K+ channels are major players contributing to intestinal anion and fluid secretion.	KCNQ1 CFTR	3.47e-06	5	21	2	29143340
Pubmed	Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.	ARHGEF18 ARHGEF28	3.24e-04	44	21	2	20200978
Pubmed	Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.	KCNQ1 SMARCAD1	5.43e-04	57	21	2	24952745
GeneFamily	Tudor domain containing	PHF20L1 SMNDC1	2.66e-04	37	12	2	780
CoexpressionAtlas	DevelopingKidney_e13.5_podocyte cells_emap-27773_k-means-cluster#5_top-relative-expression-ranked_200	CFTR SCN8A	5.88e-05	13	19	2	gudmap_developingKidney_e13.5_podocyte cells_200_k5
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-intestinal_crypt_stem_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNQ1 PUM3 CFTR ARHGEF28	1.74e-06	190	21	4	52c59001a079c76249abbaa3141e9e661b83d9a0
Drug	7,8-benzoquinoline	KCNQ1 CFTR	8.09e-06	5	21	2	ctd:C117298
Drug	cromakalim	KCNQ1 GUCY2F CFTR	7.06e-05	88	21	3	CID000071191
Drug	sildenafil	GUCY2F CFTR PDE8A	9.14e-05	96	21	3	CID000005212
Drug	5,6-benzoquinoline	KCNQ1 CFTR	2.40e-04	25	21	2	CID000006796
Drug	IBMX	KCNQ1 GUCY2F CFTR PDE8A	3.23e-04	368	21	4	CID000003758
Drug	milrinone	GUCY2F CFTR PDE8A	3.42e-04	150	21	3	CID000004197
Drug	chromanol 293B	KCNQ1 CFTR	4.20e-04	33	21	2	CID000121846
Drug	4-chromanol	KCNQ1 CFTR	4.73e-04	35	21	2	CID000092890
Drug	Uroguanylin	GUCY2F CFTR	5.01e-04	36	21	2	CID005488765
Drug	1-EBIO	KCNQ1 CFTR	5.29e-04	37	21	2	CID000082320
Drug	papaverine	GUCY2F CFTR PDE8A	5.45e-04	176	21	3	CID000004680
Drug	Chlorides	KCNQ1 CFTR	6.82e-04	42	21	2	ctd:D002712
Drug	guanylin	GUCY2F CFTR	7.49e-04	44	21	2	CID005489468
Drug	Roxithromycin [80214-83-1]; Up 200; 4.8uM; MCF7; HT_HG-U133A	KCNQ1 CFTR ARHGEF28	7.79e-04	199	21	3	4778_UP
Drug	AC1Q646P	KCNQ1 PDE8A	8.54e-04	47	21	2	CID000005673
Drug	p-Chloromercuribenzoic Acid	PHF20L1 CCDC136 CFTR ARHGEF28 SCN8A	1.19e-03	908	21	5	ctd:D020245
Drug	indazole	GUCY2F CFTR	1.21e-03	56	21	2	CID000009221
Drug	methylglucamine	CFTR SCN8A	1.48e-03	62	21	2	CID000004049
Drug	bupranolol	KCNQ1 CFTR	1.53e-03	63	21	2	CID000002475
Drug	rolipram	GUCY2F CFTR PDE8A	1.56e-03	253	21	3	CID000005092
Drug	NaCl	GUCY2F PIK3R5 CCDC136 CFTR	1.59e-03	564	21	4	CID000005234
Drug	MDL-12330A	GUCY2F CFTR	1.68e-03	66	21	2	CID000004024
Disease	QT interval	PHF20L1 KCNQ1 SMARCAD1 ARHGEF28	4.97e-04	534	21	4	EFO_0004682
Disease	hearing loss	EXOC6 ARHGEF28	1.04e-03	67	21	2	EFO_0004238
Disease	3-hydroxypropylmercapturic acid measurement	EXOC6 PIK3R5 CFTR	1.91e-03	352	21	3	EFO_0007014

Protein segments in the cluster

Peptide	Gene	Start	Entry
NKKFQNLIKKIGNFS	ARHGEF18	571	Q6ZSZ5
GELFEKAKQNNNNRK	CFTR	406	P13569
KFQPANKFNKKRKFQ	PUM3	81	Q15397
NKKFQNFIKLRNSNL	ARHGEF28	971	Q8N1W1
RNQQVKQAFKAVFRK	OR6C70	291	A6NIJ9
FALKVQQKQRQKHFN	KCNQ1	351	P51787
NNAKNKRTNNENNKK	KIAA1109	2636	Q2LD37
KFKDIPFNKNNKFNA	KIAA1586	586	Q9HCI6
YAKKKNGDNIQQNVK	PDE8A	291	O60658
SKKNNIFAQFRKNDR	EXOC6	766	Q8TAG9
FNQFKTFNKGKKTNI	GUCY2F	806	P51841
SNNKEQKQNFKAQKT	CCDC168	2686	Q8NDH2
NKRKNNQGNSFQAKR	PHF20L1	261	A8MW92
KLNFGNKDQNVKFRK	RSRC2	356	Q7L4I2
AQNGFNKKRKKNVFN	SMARCAD1	336	Q9H4L7
KEARGKNANKNMNKN	CCDC136	976	Q96JN2
KNANKNMNKNANGVK	CCDC136	981	Q96JN2
NKRMQFTKAKQNKFN	TRAM1L1	106	Q8N609
VKRQNSKSKKGFNQI	PIK3R5	781	Q8WYR1
NFNQQKKKFGGQDIF	SCN8A	1466	Q9UQD0
QEQQLTKKNNGFFQK	SMCO2	21	A6NFE2
FNNRAYSKNKKGQVK	SMNDC1	181	O75940
QNAKDFFRVLNLNKK	NARF	71	Q9UHQ1