Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	thymus development	TGFBR1 CACNB4 MAPK1 BRAF	6.46e-06	61	41	4	GO:0048538
Domain	Guanylate_kin	MAGI2 CACNB4	1.41e-03	26	40	2	PF00625
Domain	GK/Ca_channel_bsu	MAGI2 CACNB4	1.41e-03	26	40	2	IPR008145
Domain	Guanylate_kin-like_dom	MAGI2 CACNB4	1.41e-03	26	40	2	IPR008144
Domain	GuKc	MAGI2 CACNB4	1.41e-03	26	40	2	SM00072
Domain	P-loop_NTPase	MAGI2 CACNB4 MYO15B DNAH12 GAL3ST1 N4BP2 DDX28	1.95e-03	848	40	7	IPR027417
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF KIT	1.36e-06	14	23	3	M47365
Pathway	KEGG_MEDICUS_REFERENCE_KITLG_KIT_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF KIT	1.70e-06	15	23	3	M47472
Pathway	WP_GROWTH_FACTORS_AND_HORMONES_IN_BETA_CELL_PROLIFERATION	TGFBR1 MAPK1 BRAF	9.63e-06	26	23	3	M48092
Pathway	WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS	TGFBR1 MAPK1 BRAF	1.82e-05	32	23	3	M39893
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_BRAF_TO_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.54e-05	5	23	2	M49016
Pathway	WP_NEOVASCULARIZATION_PROCESSES	TGFBR1 MAPK1 KIT	2.84e-05	37	23	3	M39506
Pathway	WP_BLADDER_CANCER	THBS1 MAPK1 BRAF	3.60e-05	40	23	3	M39523
Pathway	REACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY	MAPK1 BRAF	3.80e-05	6	23	2	M27559
Pathway	REACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY	MAPK1 BRAF	3.80e-05	6	23	2	MM15273
Pathway	KEGG_BLADDER_CANCER	THBS1 MAPK1 BRAF	4.18e-05	42	23	3	M19096
Pathway	KEGG_ACUTE_MYELOID_LEUKEMIA	MAPK1 BRAF KIT	1.05e-04	57	23	3	M19888
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	1.14e-04	10	23	2	M47374
Pathway	KEGG_MEDICUS_VARIANT_HRAS_OVEREXPRESSION_TO_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	1.14e-04	10	23	2	M47420
Pathway	KEGG_MEDICUS_REFERENCE_RAC_CDC42_PAK_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	1.14e-04	10	23	2	M47735
Pathway	KEGG_COLORECTAL_CANCER	TGFBR1 MAPK1 BRAF	1.35e-04	62	23	3	M14631
Pathway	KEGG_MEDICUS_VARIANT_RET_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	1.39e-04	11	23	2	M47370
Pathway	KEGG_MEDICUS_VARIANT_TRK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	1.39e-04	11	23	2	M47371
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	1.66e-04	12	23	2	M47369
Pathway	KEGG_MEDICUS_PATHOGEN_HBV_LHBS_TO_PKC_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	1.66e-04	12	23	2	M47597
Pathway	KEGG_MEDICUS_ENV_FACTOR_METALS_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	1.66e-04	12	23	2	M47815
Pathway	WP_ACUTE_MYELOID_LEUKEMIA	MAPK1 BRAF KIT	1.77e-04	68	23	3	M48322
Pathway	WP_MELANOMA	MAPK1 BRAF KIT	1.77e-04	68	23	3	M39811
Pathway	KEGG_PANCREATIC_CANCER	TGFBR1 MAPK1 BRAF	1.93e-04	70	23	3	M9726
Pathway	KEGG_MEDICUS_PATHOGEN_HCV_CORE_TO_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	1.96e-04	13	23	2	M47589
Pathway	KEGG_CHRONIC_MYELOID_LEUKEMIA	TGFBR1 MAPK1 BRAF	2.19e-04	73	23	3	M321
Pathway	WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER	TGFBR1 MAPK1 BRAF	2.19e-04	73	23	3	M39758
Pathway	KEGG_ADHERENS_JUNCTION	TGFBR1 MAPK1 PTPRB	2.19e-04	73	23	3	M638
Pathway	KEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.29e-04	14	23	2	M47364
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.29e-04	14	23	2	M47366
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.29e-04	14	23	2	M47378
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PLCG_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.29e-04	14	23	2	M47383
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PLCG_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.29e-04	14	23	2	M47384
Pathway	REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS	MAPK1 BRAF	2.29e-04	14	23	2	M622
Pathway	REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS	MAPK1 BRAF	2.29e-04	14	23	2	MM14667
Pathway	PID_TCR_RAS_PATHWAY	MAPK1 BRAF	2.29e-04	14	23	2	M134
Pathway	KEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.29e-04	14	23	2	M47488
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.64e-04	15	23	2	M47367
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.64e-04	15	23	2	M47375
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.64e-04	15	23	2	M47382
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.64e-04	15	23	2	M47380
Pathway	KEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.64e-04	15	23	2	M47592
Pathway	KEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.64e-04	15	23	2	M47593
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_FGF17_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.64e-04	15	23	2	M47640
Pathway	KEGG_MEDICUS_VARIANT_IGF2_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.64e-04	15	23	2	M47485
Pathway	KEGG_MEDICUS_REFERENCE_HGF_MET_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.64e-04	15	23	2	M47473
Pathway	KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.64e-04	15	23	2	M47474
Pathway	KEGG_MEDICUS_REFERENCE_TGFA_EGFR_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.64e-04	15	23	2	M47480
Pathway	KEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.64e-04	15	23	2	M47495
Pathway	KEGG_MEDICUS_REFERENCE_EREG_EGFR_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.64e-04	15	23	2	M47496
Pathway	KEGG_MEDICUS_REFERENCE_AREG_EGFR_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.64e-04	15	23	2	M47497
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_GB_TO_PDGFR_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.64e-04	15	23	2	M47535
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E5_TO_EGFR_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	2.64e-04	15	23	2	M47531
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	3.01e-04	16	23	2	M47363
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_FGFR3_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	3.01e-04	16	23	2	M47373
Pathway	BIOCARTA_SPRY_PATHWAY	MAPK1 PTPRB	3.01e-04	16	23	2	MM1500
Pathway	KEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	3.01e-04	16	23	2	M47381
Pathway	KEGG_MEDICUS_REFERENCE_P4_PR_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	3.01e-04	16	23	2	M47804
Pathway	KEGG_MEDICUS_ENV_FACTOR_E2_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	3.01e-04	16	23	2	M47801
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGF1R_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	3.01e-04	16	23	2	M47483
Pathway	KEGG_MEDICUS_REFERENCE_AGE_RAGE_SIGNALING_PATHWAY	MAPK1 BRAF	3.01e-04	16	23	2	M47682
Pathway	REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING	MAPK1 BRAF	3.01e-04	16	23	2	MM14541
Pathway	REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING	MAPK1 BRAF	3.01e-04	16	23	2	M514
Pathway	BIOCARTA_SPRY_PATHWAY	MAPK1 PTPRB	3.41e-04	17	23	2	M1389
Pathway	KEGG_MEDICUS_REFERENCE_PDGF_PDGFR_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	3.41e-04	17	23	2	M47376
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_AGE_RAGE_SIGNALING_PATHWAY	MAPK1 BRAF	3.41e-04	17	23	2	M47684
Pathway	KEGG_TGF_BETA_SIGNALING_PATHWAY	TGFBR1 THBS1 MAPK1	3.55e-04	86	23	3	M2642
Pathway	WP_INHIBITION_OF_EXOSOME_BIOGENESIS_AND_SECRETION_BY_MANUMYCIN_A_IN_CRPC_CELLS	MAPK1 BRAF	3.83e-04	18	23	2	M39737
Pathway	WP_PANCREATIC_ADENOCARCINOMA_PATHWAY	TGFBR1 MAPK1 BRAF	3.93e-04	89	23	3	M39732
Pathway	WP_SEROTONIN_RECEPTOR_467_AND_NR3C_SIGNALING	MAPK1 BRAF	4.28e-04	19	23	2	M39358
Pathway	KEGG_MEDICUS_REFERENCE_CXCL12_CXCR4_PKC_ERK_SIGNALING_PATHAWAY	MAPK1 BRAF	4.28e-04	19	23	2	M47596
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	4.28e-04	19	23	2	M47793
Pathway	KEGG_MEDICUS_REFERENCE_GF_RTK_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF KIT	4.33e-04	92	23	3	M47927
Pathway	KEGG_MEDICUS_REFERENCE_ACH_CHRN_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	5.25e-04	21	23	2	M47792
Pathway	WP_MAPK_SIGNALING	TGFBR1 CACNB4 MAPK1 BRAF	6.17e-04	246	23	4	M39597
Pathway	KEGG_MEDICUS_REFERENCE_E2_ER_RAS_ERK_SIGNALING_PATHWAY	MAPK1 BRAF	6.31e-04	23	23	2	M47799
Pathway	WP_ESTROGEN_SIGNALING	MAPK1 BRAF	6.31e-04	23	23	2	M39672
Pathway	BIOCARTA_BAD_PATHWAY	MAPK1 KIT	6.88e-04	24	23	2	MM1467
Pathway	WP_RELATIONSHIP_BETWEEN_INFLAMMATION_COX2_AND_EGFR	MAPK1 BRAF	7.47e-04	25	23	2	M39794
Pathway	WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE	TGFBR1 MAPK1	7.47e-04	25	23	2	M39713
Pathway	REACTOME_TRANSCRIPTIONAL_AND_POST_TRANSLATIONAL_REGULATION_OF_MITF_M_EXPRESSION_AND_ACTIVITY	MAPK1 KIT	7.47e-04	25	23	2	MM17240
Pathway	BIOCARTA_BAD_PATHWAY	MAPK1 KIT	7.47e-04	25	23	2	M85
Pathway	WP_NOVEL_JUNDMP1_PATHWAY	MAPK1 BRAF	7.47e-04	25	23	2	MM15984
Pathway	REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK	PHLPP1 MAPK1 KIT	7.90e-04	113	23	3	MM14783
Pathway	REACTOME_SIGNALLING_TO_ERKS	MAPK1 BRAF	8.08e-04	26	23	2	MM14716
Pathway	PID_ALK1_PATHWAY	TGFBR1 MAPK1	8.08e-04	26	23	2	M185
Pathway	REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI	MGAT3 ST8SIA3	8.08e-04	26	23	2	M979
Pathway	KEGG_MAPK_SIGNALING_PATHWAY	TGFBR1 CACNB4 MAPK1 BRAF	8.39e-04	267	23	4	M10792
Pathway	REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK	PHLPP1 MAPK1 KIT	8.96e-04	118	23	3	M713
Pathway	WP_MAPK_CASCADE	MAPK1 BRAF	9.38e-04	28	23	2	MM15976
Pathway	WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY	TGFBR1 MAPK1	9.38e-04	28	23	2	M42541
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FGFR3_SIGNALING	MAPK1 BRAF	1.01e-03	29	23	2	M27528
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FGFR3_SIGNALING	MAPK1 BRAF	1.01e-03	29	23	2	MM15253
Pathway	KEGG_THYROID_CANCER	MAPK1 BRAF	1.01e-03	29	23	2	M523
Pathway	REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI	MGAT3 ST8SIA3	1.01e-03	29	23	2	MM15699
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FGFR4_SIGNALING	MAPK1 BRAF	1.15e-03	31	23	2	M27529
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FGFR4_SIGNALING	MAPK1 BRAF	1.15e-03	31	23	2	MM15254
Pathway	WP_MAPK_CASCADE	MAPK1 BRAF	1.30e-03	33	23	2	M39594
Pathway	WP_BDNFTRKB_SIGNALING	MAPK1 BRAF	1.30e-03	33	23	2	M39532
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FGFR1_SIGNALING	MAPK1 BRAF	1.30e-03	33	23	2	M27526
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FGFR2_SIGNALING	MAPK1 BRAF	1.30e-03	33	23	2	MM15252
Pubmed	Mutant-specific BRAF and CD117 immunocytochemistry potentially facilitate risk stratification for papillary thyroid carcinoma in fine-needle aspiration biopsy specimens.	BRAF KIT	1.42e-06	2	42	2	26240026
Pubmed	Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf.	MAPK1 BRAF	1.42e-06	2	42	2	14654779
Pubmed	Oncogenic B-Raf signaling in melanoma cells controls a network of microRNAs with combinatorial functions.	MAPK1 BRAF	1.42e-06	2	42	2	22751131
Pubmed	Assessment of BRAF and KIT mutations in Japanese melanoma patients.	BRAF KIT	1.42e-06	2	42	2	22534474
Pubmed	BRAF mutations and KIT aberrations and their clinicopathological correlation in 202 Korean melanomas.	BRAF KIT	1.42e-06	2	42	2	23014346
Pubmed	Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells.	TGFBR1 BRAF	1.42e-06	2	42	2	27835901
Pubmed	Unexpected distribution of cKIT and BRAF mutations among southern Italian patients with sinonasal melanoma.	BRAF KIT	1.42e-06	2	42	2	23817129
Pubmed	Immunomodulatory Properties of BRAF and MEK Inhibitors Used for Melanoma Therapy-Paradoxical ERK Activation and Beyond.	MAPK1 BRAF	1.42e-06	2	42	2	34576054
Pubmed	BRAF and KIT somatic mutations are present in amelanotic melanoma.	BRAF KIT	1.42e-06	2	42	2	23938765
Pubmed	Comparative profiles of BRAF inhibitors: the paradox index as a predictor of clinical toxicity.	MAPK1 BRAF	1.42e-06	2	42	2	27028853
Pubmed	Targeting mutant BRAF and KIT in metastatic melanoma: ASCO 2009 meeting report.	BRAF KIT	1.42e-06	2	42	2	19624312
Pubmed	BRAF, KIT and NRAS mutations and expression of c-KIT, phosphorylated extracellular signal-regulated kinase and phosphorylated AKT in Japanese melanoma patients.	BRAF KIT	1.42e-06	2	42	2	25766129
Pubmed	Anaplastic thyroid cancer: outcome and the mutation/expression profiles of potential targets.	BRAF KIT	1.42e-06	2	42	2	25588542
Pubmed	B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression.	THBS1 BRAF	1.42e-06	2	42	2	20498063
Pubmed	Amelanotic acral melanomas: clinicopathological, BRAF mutation, and KIT aberration analyses.	BRAF KIT	1.42e-06	2	42	2	23972510
Pubmed	Melanoma hyperpigmentation is strongly associated with KIT alterations.	BRAF KIT	1.42e-06	2	42	2	19652585
Pubmed	Lack of cytoplasmic ERK activation is an independent adverse prognostic factor in primary cutaneous melanoma.	MAPK1 BRAF	4.27e-06	3	42	2	18509361
Pubmed	Adhesion-dependent activation of the ERK1/2 cascade is by-passed in melanoma cells.	MAPK1 BRAF	4.27e-06	3	42	2	12821662
Pubmed	KIT, NRAS and BRAF mutations in sinonasal mucosal melanoma: a study of 56 cases.	BRAF KIT	4.27e-06	3	42	2	23860532
Pubmed	Upstream mitogen-activated protein kinase (MAPK) pathway inhibition: MEK inhibitor followed by a BRAF inhibitor in advanced melanoma patients.	MAPK1 BRAF	4.27e-06	3	42	2	24183461
Pubmed	Comparative analysis of BRAF, NRAS and c-KIT mutation status between tumor tissues and autologous tumor cell-lines of stage III/IV melanoma.	BRAF KIT	4.27e-06	3	42	2	25363723
Pubmed	Oncogene mutational analysis in imatinib naive population of gastrointestinal stromal tumor patients.	BRAF KIT	4.27e-06	3	42	2	34174973
Pubmed	Mutation of B-Raf in human choroidal melanoma cells mediates cell proliferation and transformation through the MEK/ERK pathway.	MAPK1 BRAF	4.27e-06	3	42	2	12917419
Pubmed	Molecular characterization of PDGFR-alpha/PDGF-A and c-KIT/SCF in gliosarcomas.	BRAF KIT	4.27e-06	3	42	2	16373964
Pubmed	BRAF, NRAS and C-KIT Advanced Melanoma: Clinico-pathological Features, Targeted-Therapy Strategies and Survival.	BRAF KIT	4.27e-06	3	42	2	29187493
Pubmed	Comparison of molecular abnormalities in vulvar and vaginal melanomas.	BRAF KIT	4.27e-06	3	42	2	24603591
Pubmed	The positive feedback loop of NHE1-ERK phosphorylation mediated by BRAFV600E mutation contributes to tumorigenesis and development of glioblastoma.	MAPK1 BRAF	4.27e-06	3	42	2	34933181
Pubmed	Constant activation of the RAF-MEK-ERK pathway as a diagnostic and therapeutic target in hairy cell leukemia.	MAPK1 BRAF	4.27e-06	3	42	2	23349307
Pubmed	Mutations in the BRAF, NRAS, and C-KIT Genes of Patients Diagnosed with Melanoma in Colombia Population.	BRAF KIT	4.27e-06	3	42	2	32775409
Pubmed	Prevalence of BRAF, NRAS and c-KIT mutations in Slovenian patients with advanced melanoma.	BRAF KIT	4.27e-06	3	42	2	30210039
Pubmed	Expression of c-Kit, p-ERK and cyclin D1 in malignant melanoma: an immunohistochemical study and analysis of prognostic value.	MAPK1 KIT	4.27e-06	3	42	2	21454057
Pubmed	RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation.	MAPK1 BRAF	4.27e-06	3	42	2	33707308
Pubmed	Bioinformatic analysis reveals hub genes and pathways that promote melanoma metastasis.	THBS1 KIT	4.27e-06	3	42	2	32894090
Pubmed	Clinical characteristics associated with BRAF, NRAS and KIT mutations in Japanese melanoma patients.	BRAF KIT	4.27e-06	3	42	2	26282084
Pubmed	hnRNP-K is a nuclear target of TCR-activated ERK and required for T-cell late activation.	MAPK1 HNRNPK	4.27e-06	3	42	2	19880579
Pubmed	Clinicopathological and molecular features of a large cohort of gastrointestinal stromal tumors (GISTs) and review of the literature: BRAF mutations in KIT/PDGFRA wild-type GISTs are rare events.	BRAF KIT	4.27e-06	3	42	2	28159677
Pubmed	ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer.	MAPK1 BRAF	4.27e-06	3	42	2	29988110
Pubmed	KIT, NRAS, and BRAF mutations in nail apparatus melanoma.	BRAF KIT	4.27e-06	3	42	2	23782496
Pubmed	BRAF, NRAS and KIT sequencing analysis of spindle cell melanoma.	BRAF KIT	4.27e-06	3	42	2	22809251
Pubmed	Gastrointestinal stromal tumors - Summary of mutational status of the primary/secondary KIT/PDGFRA mutations, BRAF mutations and SDH defects.	BRAF KIT	4.27e-06	3	42	2	31708372
Pubmed	KIT Suppresses BRAFV600E-Mutant Melanoma by Attenuating Oncogenic RAS/MAPK Signaling.	BRAF KIT	4.27e-06	3	42	2	28947418
Pubmed	KIT gene mutations and copy number in melanoma subtypes.	BRAF KIT	4.27e-06	3	42	2	18980976
Pubmed	Detection of mutations in the BRAF gene in patients with KIT and PDGFRA wild-type gastrointestinal stromal tumors.	BRAF KIT	4.27e-06	3	42	2	27864688
Pubmed	A subset of colorectal carcinomas express c-KIT protein independently of BRAF and/or KRAS activation.	BRAF KIT	4.27e-06	3	42	2	17487504
Pubmed	Malignant Melanoma of Vulva and Vagina: A Histomorphological Review and Mutation Analysis--A Single-Center Study.	BRAF KIT	4.27e-06	3	42	2	26225944
Pubmed	Discrepant alterations in main candidate genes among multiple primary melanomas.	BRAF KIT	4.27e-06	3	42	2	24885594
Pubmed	KIT, PDGFRA, and BRAF mutational spectrum impacts on the natural history of imatinib-naive localized GIST: a population-based study.	BRAF KIT	4.27e-06	3	42	2	25970686
Pubmed	Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.	BRAF KIT	8.53e-06	4	42	2	18632627
Pubmed	Activation of extracellular regulated kinases (ERK1/2) predicts poor prognosis in urothelial bladder carcinoma and is not associated with B-Raf gene mutations.	MAPK1 BRAF	8.53e-06	4	42	2	19404844
Pubmed	Metformin decreases angiogenesis via NF-kappaB and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1.	THBS1 MAPK1	8.53e-06	4	42	2	19414528
Pubmed	Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury.	MAPK1 KIT	8.53e-06	4	42	2	27468693
Pubmed	MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes.	MAPK1 KIT	8.53e-06	4	42	2	9440696
Pubmed	Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades.	MAPK1 BRAF	8.53e-06	4	42	2	15632082
Pubmed	ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma.	MAPK1 BRAF	8.53e-06	4	42	2	29295999
Pubmed	Hsp90·Cdc37 Complexes with Protein Kinases Form Cooperatively with Multiple Distinct Interaction Sites.	MAPK1 BRAF	8.53e-06	4	42	2	26511315
Pubmed	Localization of active, dually phosphorylated extracellular signal-regulated kinase 1 and 2 in colorectal cancer with or without activating BRAF and KRAS mutations.	MAPK1 BRAF	8.53e-06	4	42	2	27036313
Pubmed	Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT.	MAPK1 KIT	8.53e-06	4	42	2	21084381
Pubmed	TbetaRI/Alk5-independent TbetaRII signaling to ERK1/2 in human skin cells according to distinct levels of TbetaRII expression.	TGFBR1 MAPK1	8.53e-06	4	42	2	21172820
Pubmed	KIT, NRAS, BRAF and PTEN mutations in a sample of Swedish patients with acral lentiginous melanoma.	BRAF KIT	8.53e-06	4	42	2	23993026
Pubmed	C-Raf inhibits MAPK activation and transformation by B-Raf(V600E).	MAPK1 BRAF	8.53e-06	4	42	2	19917255
Pubmed	Mutation of IGFBP7 causes upregulation of BRAF/MEK/ERK pathway and familial retinal arterial macroaneurysms.	MAPK1 BRAF	8.53e-06	4	42	2	21835307
Pubmed	Wilms tumor gene 1 (WT1), TP53, RAS/BRAF and KIT aberrations in testicular germ cell tumors.	BRAF KIT	8.53e-06	4	42	2	27085458
Pubmed	Gastrointestinal stromal tumors with BRAF gene fusions. A report of two cases showing low or absent KIT expression resulting in diagnostic pitfalls.	BRAF KIT	8.53e-06	4	42	2	34398495
Pubmed	Elastin peptides activate extracellular signal-regulated kinase 1/2 via a Ras-independent mechanism requiring both p110gamma/Raf-1 and protein kinase A/B-Raf signaling in human skin fibroblasts.	MAPK1 BRAF	8.53e-06	4	42	2	15653554
Pubmed	Genetic aberrations in primary esophageal melanomas: molecular analysis of c-KIT, PDGFR, KRAS, NRAS and BRAF in a series of 10 cases.	BRAF KIT	1.42e-05	5	42	2	21131919
Pubmed	A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease.	BRAF KIT	1.42e-05	5	42	2	31685822
Pubmed	Inhibition of Ras/Raf interaction by anti-oncogenic mutants of neurofibromin, the neurofibromatosis type 1 (NF1) gene product, in cell-free systems.	MAPK1 BRAF	1.42e-05	5	42	2	7499408
Pubmed	Mutation scanning of BRAF, NRAS, KIT, and GNAQ/GNA11 in oral mucosal melanoma: a study of 57 cases.	BRAF KIT	1.42e-05	5	42	2	26399561
Pubmed	Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2.	MAPK1 BRAF	1.42e-05	5	42	2	26285778
Pubmed	Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence.	MAPK1 PTPRB	1.42e-05	5	42	2	12840032
Pubmed	ARID1B maintains mesenchymal stem cell quiescence via inhibition of BCL11B-mediated non-canonical Activin signaling.	TGFBR1 MAPK1	2.13e-05	6	42	2	38816354
Pubmed	Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway.	MBTPS1 KIT	2.13e-05	6	42	2	15938716
Pubmed	Combinatorial activities of Akt and B-Raf/Erk signaling in a mouse model of androgen-independent prostate cancer.	MAPK1 BRAF	2.13e-05	6	42	2	16973750
Pubmed	Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.	MAPK1 BRAF	2.13e-05	6	42	2	8157000
Pubmed	B-Raf and CRHR1 internalization mediate biphasic ERK1/2 activation by CRH in hippocampal HT22 Cells.	MAPK1 BRAF	2.13e-05	6	42	2	23371389
Pubmed	Functional Analysis of KIT Gene Structural Mutations Causing the Porcine Dominant White Phenotype Using Genome Edited Mouse Models.	MAPK1 KIT	2.13e-05	6	42	2	32194624
Pubmed	Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice.	MAPK1 BRAF KIT	2.24e-05	45	42	3	28973166
Pubmed	Large-scale structural analysis of the classical human protein tyrosine phosphatome.	PTPRB KIT PKP4	2.56e-05	47	42	3	19167335
Pubmed	c-Kit mutants require hypoxia-inducible factor 1alpha to transform melanocytes.	MAPK1 KIT	2.98e-05	7	42	2	19802003
Pubmed	Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia.	TGFBR1 BRAF	2.98e-05	7	42	2	35931031
Pubmed	Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.	TGFBR1 BRAF	2.98e-05	7	42	2	34103493
Pubmed	Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome.	MAPK1 BRAF	2.98e-05	7	42	2	21383153
Pubmed	IQGAP1 integrates Ca2+/calmodulin and B-Raf signaling.	MAPK1 BRAF	2.98e-05	7	42	2	18567582
Pubmed	Polymorphisms in the transforming growth factor beta 1 pathway in relation to colorectal cancer progression.	TGFBR1 THBS1	2.98e-05	7	42	2	19998449
Pubmed	c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma.	MAPK1 BRAF	3.97e-05	8	42	2	21514245
Pubmed	IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds.	MAPK1 BRAF	3.97e-05	8	42	2	18332145
Pubmed	KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development.	MAPK1 KIT	3.97e-05	8	42	2	19914172
Pubmed	Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas.	BRAF KIT	5.10e-05	9	42	2	20838624
Pubmed	Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis.	MAPK1 KIT	5.10e-05	9	42	2	30166337
Pubmed	Ablation of BRaf impairs neuronal differentiation in the postnatal hippocampus and cerebellum.	MAPK1 BRAF	5.10e-05	9	42	2	23505473
Pubmed	Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos.	MAPK1 KIT	5.10e-05	9	42	2	26460546
Pubmed	A-raf and B-raf are dispensable for normal endochondral bone development, and parathyroid hormone-related peptide suppresses extracellular signal-regulated kinase activation in hypertrophic chondrocytes.	MAPK1 BRAF	5.10e-05	9	42	2	17967876
Pubmed	Essential role of B-Raf in ERK activation during extraembryonic development.	MAPK1 BRAF	6.37e-05	10	42	2	16432225
Pubmed	Adult mice expressing a Braf Q241R mutation on an ICR/CD-1 background exhibit a cardio-facio-cutaneous syndrome phenotype.	MAPK1 BRAF	6.37e-05	10	42	2	26472072
Pubmed	FGF signaling regulates salivary gland branching morphogenesis by modulating cell adhesion.	MAPK1 BRAF	6.37e-05	10	42	2	36861436
Pubmed	Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development.	MAPK1 BRAF	6.37e-05	10	42	2	18952847
Pubmed	Cortical migration defects in mice expressing A-RAF from the B-RAF locus.	MAPK1 BRAF	6.37e-05	10	42	2	16980614
Pubmed	Gestational loss and growth restriction by angiogenic defects in placental growth factor transgenic mice.	MAPK1 BRAF	7.78e-05	11	42	2	25147341
Pubmed	KRAS or BRAF mutations cause hepatic vascular cavernomas treatable with MAP2K-MAPK1 inhibition.	MAPK1 BRAF	9.32e-05	12	42	2	32405640
Pubmed	Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele.	MAPK1 KIT	9.32e-05	12	42	2	23077213
Cytoband	2p13.3	PLEK PCYOX1	5.05e-04	36	42	2	2p13.3
Cytoband	22q12.2	GAL3ST1 SF3A1	1.31e-03	58	42	2	22q12.2
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	MAGI2 CACNB4	5.85e-04	26	25	2	904
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PHLPP1 PLEK FGD6	2.79e-03	206	25	3	682
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MGAT3 PALMD PTPRB DDX28	1.20e-05	150	42	4	322aa0c3fc159a4b2897daac881dfc744b24ffc4
ToppCell	facs-Marrow-KLS-24m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PBX4 OOSP1 KIT CYP2G1P	1.44e-05	157	42	4	3c6be6995c00c4cadbd209c66bf9a87c8c238652
ToppCell	facs-Marrow-KLS-24m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PBX4 OOSP1 KIT CYP2G1P	1.44e-05	157	42	4	662d5026e0e4249029fc6f3abc771d775d7bc3bb
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PALD1 NAALADL1 GAL3ST1 DDX28	1.51e-05	159	42	4	1dde4d19cc0fde7ebbccb4c31bb845a92206021b
ToppCell	BL-critical-LOC-Myeloid-Basophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PALD1 THBS1 FADS3 KIT	1.63e-05	162	42	4	25ec9df914445b4daae4fd28fd0e60b64797c46d
ToppCell	Endothelial-endothelial_cell_of_bronchial_vessel\|World / Lineage, Cell type, age group and donor	PALMD PTPRB KIT PKP4	1.75e-05	165	42	4	84e553d699ac56df89a77248f7308b9133e1b683
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MGAT3 PALMD PTPRB PKP4	2.01e-05	171	42	4	b3e6e31dfe3623b960ccf692fdbd236fa4039923
ToppCell	Adult-Endothelial-endothelial_cell_of_bronchial_vessel\|Adult / Lineage, Cell type, age group and donor	MYO15B PALMD PTPRB KIT	2.06e-05	172	42	4	ad4ffdb3fc0c560a9cbaa2bc048476cbc43e8fd6
ToppCell	E16.5-samps-Endothelial-Immature_fetal_endothelial-Proliferative_Endothelial\|E16.5-samps / Age Group, Lineage, Cell class and subclass	PALD1 PALMD PTPRB KIT	2.41e-05	179	42	4	d24513a404c9b1d37dd47aa1cdb5713b64b88f89
ToppCell	390C-Lymphocytic-NK_cells-Proliferating_NK_cell\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	DNAH12 SAXO1 PKP4 PRTFDC1	2.41e-05	179	42	4	e67ad7ab04d0c1309296f57c1f53c5ca14c213fe
ToppCell	droplet-Fat-Gat-18m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C8orf82 PALMD KIT PKP4	2.41e-05	179	42	4	08cf9986804a6417a9afb19b50c69a3554f71ec6
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNB4 GAL3ST1 KCNT1 PKP4	2.46e-05	180	42	4	0b653b1b653b40f3b8711d1312029a4a8a4961db
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNB4 GAL3ST1 KCNT1 PKP4	2.63e-05	183	42	4	6b5fa169477821355d1ab7aa11935cdfde1c339c
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-Tuft-related-Tuft\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZFHX3 AOC1 KIT A2ML1	2.74e-05	185	42	4	686ed7550c6acd18e71e0076936ec5b07389adbd
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PALD1 PALMD PTPRB KIT	2.98e-05	189	42	4	e82211b9dc7540e7a183be2cbcfae39fdf503949
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNB4 GAL3ST1 KCNT1 PKP4	3.04e-05	190	42	4	c247562df3e1aa3173c9f01a74d5831f0764a1b2
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNB4 GAL3ST1 KCNT1 PKP4	3.04e-05	190	42	4	5cea8298c8336c136ba009630c9e48d4bc832cb2
ToppCell	E16.5-samps-Endothelial-Immature_fetal_endothelial\|E16.5-samps / Age Group, Lineage, Cell class and subclass	PALD1 PALMD PTPRB KIT	3.10e-05	191	42	4	44c596984c6196f6014e0e405dbe5560841e54ff
ToppCell	E16.5-samps-Endothelial\|E16.5-samps / Age Group, Lineage, Cell class and subclass	PALD1 PALMD PTPRB KIT	3.10e-05	191	42	4	e7521d4d24f016d4e531cd492a7a69604f0c9e6f
ToppCell	COVID-19-kidney-VWF+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PALD1 PTPRB KIT PKP4	3.10e-05	191	42	4	2f00d0b7b2ffce8eb3eb5bbae49a0d425b23c982
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNB4 GAL3ST1 KCNT1 PKP4	3.10e-05	191	42	4	297bc79adc5fef211497819b4861b52cd26ac754
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNB4 GAL3ST1 KCNT1 PKP4	3.10e-05	191	42	4	e1ec165ba6578cefd88895e7e183190e79f733a4
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PALMD PTPRB KIT PKP4	3.17e-05	192	42	4	0aeb5351275c0a91151ea2d52b2cdde172da6731
ToppCell	human_hepatoblastoma-Endothelial_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	PALD1 PALMD PTPRB KIT	3.17e-05	192	42	4	e09f609fed033a25baacaf4a07bbbae1076da366
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PALMD PTPRB KIT PKP4	3.23e-05	193	42	4	e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCell	LPS-antiTNF-Endothelial-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PALMD PTPRB KIT PKP4	3.23e-05	193	42	4	02f633b016ab19bfa65bfd0cf32f000549a62148
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PALMD PTPRB KIT PKP4	3.23e-05	193	42	4	6e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PALMD PTPRB KIT PKP4	3.23e-05	193	42	4	af5108260783e69a7d67896c5bf64f862525926d
ToppCell	LPS-antiTNF-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PALMD PTPRB KIT PKP4	3.23e-05	193	42	4	5122b1ffba42de190061be34ecdc6176f84e56a3
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PALMD PTPRB KIT PKP4	3.23e-05	193	42	4	ad2df9b77999780860141be6ec366afc0172a331
ToppCell	LPS-IL1RA-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PALMD PTPRB KIT PKP4	3.30e-05	194	42	4	43f92b0533e26633dc94cce554045d641ef8fd76
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PALMD PTPRB KIT PKP4	3.30e-05	194	42	4	68004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PALMD PTPRB KIT PKP4	3.30e-05	194	42	4	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	LPS-IL1RA-Endothelial-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PALMD PTPRB KIT PKP4	3.30e-05	194	42	4	1d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCell	ASK428-Endothelial-Endothelium\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	THBS1 PALMD PTPRB SETBP1	3.43e-05	196	42	4	b1a81eddb91fb462360692b7b0a3ba4a947eac40
ToppCell	Fetal_29-31_weeks-Endothelial\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PALD1 PALMD PTPRB KIT	3.43e-05	196	42	4	3981f6c7487598f4f7ce4650ac0ac5bd41481d66
ToppCell	ASK428-Endothelial\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	PALD1 THBS1 PALMD PTPRB	3.57e-05	198	42	4	d69d0ff115298596173a4278897a65007a71f5df
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PALMD PTPRB FGD6 PKP4	3.72e-05	200	42	4	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	COVID-19_Convalescent-PLT_3\|COVID-19_Convalescent / Disease Group and Platelet Clusters	THBS1 PLEK	1.15e-04	17	42	2	2ba647a831d78f853a21f9680b4276ca3ee4803d
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ZFHX3 PTPRB PLEK	1.33e-04	105	42	3	8f31edf4183587f5b53941475453c5aa49f10bbd
ToppCell	LPS-IL1RA-Myeloid-Myeloid_granulocytic-Neutrophils\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 PLEK OOSP1	1.87e-04	118	42	3	6053e19d040fb394f9c270361af07b0c5a4d47db
ToppCell	LPS-IL1RA-Myeloid-Myeloid_granulocytic\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 PLEK OOSP1	1.87e-04	118	42	3	811e8521129914eef46785a4227c1860e77d9096
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FADS3 PTPRB DDX28	1.92e-04	119	42	3	c3f1223356e7f245a460ea5568a223e34e458dc1
ToppCell	Control-Endothelial-Endothelial-Activated_Gen_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TGFBR1 MEIOC KIT	2.02e-04	121	42	3	a5962d1c476e6966870832b72d511607e047248b
ToppCell	ASK440-Endothelial-Endothelium\|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq	PALMD PTPRB KIT	2.07e-04	122	42	3	2f76ec3b527e9528fbb006599a96e8bbdf9e0e62
ToppCell	Control-PLT_5\|World / Disease Group and Platelet Clusters	NAALADL1 MEIOC APCDD1L	2.27e-04	126	42	3	4ba753c4e83eb1d41964edfa22135e047f06c481
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Esophageal_Carcinoma-Adenocarcinoma-3\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	MYO15B AOC1 GAL3ST1	3.50e-04	146	42	3	e55b4acecf4e363b5afa287c747c2e58c4597f3a
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Esophageal_Carcinoma-Adenocarcinoma\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	MYO15B AOC1 GAL3ST1	3.72e-04	149	42	3	92a8931a51db619fb5f0638d319c02e7838f6559
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PALD1 CACNB4 PKP4	3.72e-04	149	42	3	a85a051e0d82430160967e72fa04b55f43e84513
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PALD1 CACNB4 PKP4	3.79e-04	150	42	3	7a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCell	LPS-IL1RA+antiTNF-Hematopoietic_Meg-Ery-Platelets-Platelets\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CNNM1 THBS1 PLEK	3.94e-04	152	42	3	aff7d1127ef72be489477611c4decc53cc7632e3
ToppCell	LPS-IL1RA+antiTNF-Hematopoietic_Meg-Ery-Platelets\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CNNM1 THBS1 PLEK	3.94e-04	152	42	3	0a99c91165e4d82fb8825fbdf3071c9a5445669d
ToppCell	E15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PALMD PTPRB SETBP1	4.09e-04	154	42	3	e65e4636646164610f33f7bbac0d879a3ea55986
ToppCell	E16.5-samps-Endothelial-Immature_fetal_endothelial-Matrix_Endothelial\|E16.5-samps / Age Group, Lineage, Cell class and subclass	PALMD PTPRB KIT	4.09e-04	154	42	3	928f49839b046b90c2f942458f3e365ddc4e0bc9
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PALMD PTPRB KIT	4.25e-04	156	42	3	ff39712c7a2dc1b85c598d5105789aa291dea726
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PALMD PTPRB SETBP1	4.33e-04	157	42	3	275a4c6fef1fff8da2bdc48e3924ad05c5e5cfc8
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PALMD PTPRB KIT	4.33e-04	157	42	3	2c946c6ab284fac3c25db688ed0aabe5a3f9ffa5
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-Plasma_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	PALD1 MGAT3 SETBP1	4.75e-04	162	42	3	8278dccdb139396ede34b83b02ebce837f2489d6
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 PALMD PTPRB	4.75e-04	162	42	3	c399b9e4854916a59f5cae2d8dbf19660f8759be
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EECs\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DNAH12 SAXO1 ST8SIA3	4.75e-04	162	42	3	9f568836199a05f696294caac1ea3fa413984423
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 PALMD PTPRB	4.75e-04	162	42	3	a291248b693c771845174393934a782f1d8bd7ce
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-Tuft-related-Tuft\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZFHX3 AOC1 KIT	4.75e-04	162	42	3	80619a93c57fe16daf91dc571874ef9ac888953d
ToppCell	E18.5-samps-Endothelial-Mature_fetal_endothelial-endothelial_cells_B\|E18.5-samps / Age Group, Lineage, Cell class and subclass	PALMD PTPRB KIT	4.83e-04	163	42	3	d6f9b7280c44d120df5a72dfc2ebb26ffbb5752b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 PALMD PTPRB	4.83e-04	163	42	3	73c03e29a6d7a6863c5e9aa5e8b963ef691f1ddb
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Plasma_cells-IgM_plasma_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RHBDD1 MBTPS1 DNAH12	5.01e-04	165	42	3	6e8370b8e747d8ef44a2413a993291a3cd83a77c
ToppCell	control-Epithelial-Ionocyte\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	THBS1 FADS3 KIT	5.01e-04	165	42	3	5cfba9a46bd8ceeca74a6493057b4d38af6b06fe
ToppCell	droplet-Limb_Muscle-nan-3m-Myeloid-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEK KIT GAL3ST1	5.09e-04	166	42	3	0a7992bc673fca546636563ec3fc17a4298ab6b1
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PALMD PTPRB PKP4	5.09e-04	166	42	3	f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCell	NS-critical-d_0-4-Epithelial-unknown_epithelial\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CACNB4 MGAT3 SETBP1	5.09e-04	166	42	3	dd02bbe4af609c6348dc92417254f4740f2900a8
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-B_cells-LZ_GC_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FADS3 PLEK FGD6	5.27e-04	168	42	3	08eb1284f9b8bd3e0e4b21bfc2bbee01d35a0bd7
ToppCell	control-Epithelial-Ionocyte\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	THBS1 FADS3 KIT	5.27e-04	168	42	3	327b02f19f4a8607c033203824fdc60a1254331f
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	PALD1 THBS1 KIT	5.37e-04	169	42	3	a0681317867e31319210a23e56660a53f4529efe
ToppCell	356C-Endothelial_cells-Endothelial-B_(Artery)\|356C / Donor, Lineage, Cell class and subclass (all cells)	PALMD PTPRB APCDD1L	5.37e-04	169	42	3	605cc2638271803cf1d972ab3fa8f13f89666376
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TGFBR1 PALD1 ZFHX3	5.37e-04	169	42	3	0867528101767fc65e93b3561480bf830c50368d
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-Tuft-related-Tuft\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZFHX3 AOC1 KIT	5.37e-04	169	42	3	05e12524d68d409fed386ffad233305683b4575b
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD8-Trm/em_CD8\|GI_small-bowel / Manually curated celltypes from each tissue	PBX4 PALMD APCDD1L	5.37e-04	169	42	3	17568e7aacfdcd96c469bae57d5ffad04954e9bd
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Myeloid-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PBX4 CNNM1 KIT	5.37e-04	169	42	3	bca5322880c09b78ef10d9dda6420a80c1ba7e62
ToppCell	356C-Endothelial_cells-Endothelial-B_(Artery)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	PALMD PTPRB APCDD1L	5.37e-04	169	42	3	337be3bf485b54afad86e256cb0c4c1d0c2a9a2a
ToppCell	Adult-Endothelial-endothelial_cell_of_bronchial_vessel-D122\|Adult / Lineage, Cell type, age group and donor	PALMD PTPRB KIT	5.46e-04	170	42	3	a99cb3d21f8eb926886340ea99491e078e607648
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MYO15B PALMD PTPRB	5.55e-04	171	42	3	1ae4b6a25bc9c1065cf5d95998ebcc70aee21ab5
ToppCell	Control-Endothelial_cells-Systemic_venous_endothelial_cells\|Control / group, cell type (main and fine annotations)	PALMD PTPRB PKP4	5.65e-04	172	42	3	c55dce1ed3ed7312394b4e050e1de852a994e130
ToppCell	E18.5-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PHLPP1 MGAT3 PKP4	5.65e-04	172	42	3	1bbf5ed7d13635f9a7e528060341e0652699bd7c
ToppCell	368C-Endothelial_cells-Endothelial-B_(Artery)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	PALMD PTPRB APCDD1L	5.74e-04	173	42	3	ec88e871b49331fca59bc610a8ae58e2d5e76bc1
ToppCell	10x3'2.3-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	NAALADL1 PLEK KIT	5.74e-04	173	42	3	1e4afa020fae682521335b440ccd33c16f37156f
ToppCell	368C-Endothelial_cells-Endothelial-B_(Artery)\|368C / Donor, Lineage, Cell class and subclass (all cells)	PALMD PTPRB APCDD1L	5.74e-04	173	42	3	22200fe74e33e2beae0eed289ca8476bbc0b1b2d
ToppCell	Dendritic_Cells-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	PALD1 AOC1 PLEK	5.74e-04	173	42	3	ddb900ef4abeabe2e59db1009efc337e35d301fe
ToppCell	3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MGAT3 PKP4 A2ML1	5.84e-04	174	42	3	2a96a4fd7d9ef05213b26103c689cf3a26968713
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-pDC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TGFBR1 PALD1 SETBP1	5.94e-04	175	42	3	37c2d4e0b6e9a3171931797ce9a54f3347288e57
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHLPP1 PLEK KIT	5.94e-04	175	42	3	cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PALMD PTPRB KIT	5.94e-04	175	42	3	1c7725f917f3d6b9e0a31ede9524690f408a5ea1
ToppCell	facs-Heart-RV-18m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PALMD PTPRB PKP4	6.04e-04	176	42	3	fb3d03f64592e1df1d9785d9f2e70938d7ff9ce8
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PALMD PTPRB KIT	6.04e-04	176	42	3	269326c2bf44a9003d95bc6dbc839f08f25737ca
ToppCell	facs-Heart-RV-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PALMD PTPRB PKP4	6.04e-04	176	42	3	3270a36fc91a5583646ffeb70bfcbc5af7292aac
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PALMD PTPRB MEIOC	6.04e-04	176	42	3	1df7b6ce2519ad99bacbbaf1a8d5929e11513faa
ToppCell	facs-Heart-RV-18m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PALMD PTPRB PKP4	6.04e-04	176	42	3	99410c121f55adbc7fcc013c8fa8905a45dba76b
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-D_cells_(SST+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DNAH12 ST8SIA3 GAL3ST1	6.14e-04	177	42	3	8dbef0005095c01a806d8c7f723dc48a4650efec
ToppCell	Control-Myeloid-pDC\|Control / Disease state, Lineage and Cell class	TGFBR1 PALD1 SETBP1	6.14e-04	177	42	3	3940663bb5b45b2ca9f772550380a516c53e410b
ToppCell	facs-Aorta-Heart-24m-Endothelial-nan\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PALMD PTPRB PKP4	6.14e-04	177	42	3	c6b955765aee8a196fcf4f7bb16139c95b76dc4e
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PALMD PTPRB KIT	6.14e-04	177	42	3	0e74980a7686c31fcf1476b8f19a3392541df240
ToppCell	tumor_Lung-Endothelial_cells-EPCs\|tumor_Lung / Location, Cell class and cell subclass	PALMD PTPRB PKP4	6.14e-04	177	42	3	f8b152c09d56a97e8c0482fb1a3964c05f9dc8c5
Disease	platelet reactivity measurement, thrombus formation measurement	N4BP2 SETBP1	3.94e-05	7	41	2	EFO_0004985, EFO_0007615
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	MAGI2 PALD1 ZFHX3 AOC1 SETBP1	1.45e-04	364	41	5	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	platelet crit	PHLPP1 THBS1 PLEK MEIOC KIT HNRNPK PRTFDC1	3.07e-04	952	41	7	EFO_0007985
Disease	Noonan-Like Syndrome With Loose Anagen Hair	BRAF A2ML1	3.17e-04	19	41	2	C3501846
Disease	Costello syndrome (disorder)	BRAF A2ML1	3.17e-04	19	41	2	C0587248
Disease	Noonan syndrome-like disorder with loose anagen hair	BRAF A2ML1	3.17e-04	19	41	2	C1843181
Disease	Cardio-facio-cutaneous syndrome	BRAF A2ML1	3.17e-04	19	41	2	C1275081
Disease	prostate adenocarcinoma (is_implicated_in)	MAPK1 BRAF	3.52e-04	20	41	2	DOID:2526 (is_implicated_in)
Disease	cholangiocarcinoma (is_implicated_in)	THBS1 BRAF	4.28e-04	22	41	2	DOID:4947 (is_implicated_in)
Disease	LEOPARD Syndrome	BRAF A2ML1	4.28e-04	22	41	2	C0175704
Disease	Neoplasm of the genitourinary tract	ZFHX3 KIT	5.10e-04	24	41	2	cv:C0042065
Disease	Noonan Syndrome	BRAF A2ML1	5.10e-04	24	41	2	C0028326
Disease	body fat percentage	MAGI2 PALD1 ZFHX3 AOC1 SETBP1	5.56e-04	488	41	5	EFO_0007800
Disease	level of Phosphatidylcholine (17:0_20:4) in blood serum	PBX4 FADS3	5.99e-04	26	41	2	OBA_2045087
Disease	Sezary Syndrome	MAPK1 BRAF	6.47e-04	27	41	2	C0036920
Disease	Myeloid Leukemia, Chronic	BRAF SETBP1	7.47e-04	29	41	2	C0023473
Disease	level of Sterol ester (27:1/20:4) in blood serum	PBX4 FADS3	8.54e-04	31	41	2	OBA_2045198
Disease	ovarian neoplasm	MAPK1 BRAF PRTFDC1	8.60e-04	134	41	3	C0919267
Disease	Breast Carcinoma	THBS1 BRAF KIT HNRNPK SETBP1	8.62e-04	538	41	5	C0678222
Disease	Malignant neoplasm of ovary	MAPK1 BRAF PRTFDC1	9.17e-04	137	41	3	C1140680
Disease	colorectal adenocarcinoma (is_implicated_in)	MAPK1 BRAF	1.09e-03	35	41	2	DOID:0050861 (is_implicated_in)
Disease	triacylglycerol 56:8 measurement	PBX4 FADS3	1.15e-03	36	41	2	EFO_0010435
Disease	Craniofacial Abnormalities	PBX4 MBTPS1 SETBP1	1.33e-03	156	41	3	C0376634
Disease	colorectal cancer (is_marker_for)	ZFHX3 THBS1 HNRNPK	1.36e-03	157	41	3	DOID:9256 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LYLQSPHSYEDPYFD	PKP4	1131	Q99569
EHNPPSIYLEAYEEY	BRAF	71	P15056
PEPRTREYFYYVDHQ	C8orf82	36	Q6P1X6
VPRYYQNAYLHLRPF	A2ML1	431	A8K2U0
PSRLFRAHQFYYEDP	APCDD1L	81	Q8NCL9
FHYYDADDPVHYPRA	AOC1	401	P19801
DYPDSYQDTYKPHRN	CACNB4	491	O00305
LNLFTYPQHYYGDLE	PRTFDC1	26	Q9NRG1
LILFNYYLHEQYPLA	PALD1	431	Q9ULE6
QALAHPYLEQYYDPS	MAPK1	306	P28482
EYHEPVYANPFYRPT	PALMD	256	Q9NP74
YENVNPEYHRDPVYS	PTPRB	1981	P23467
QYPLSDYRQPQDFDY	MAGI2	1131	Q86UL8
DQYHNLRYPPGYFPR	MBTPS1	626	Q14703
YDRFHYLLDNPYQEP	MGAT3	491	Q09327
NNYVYIDPTQLPYDH	KIT	566	P10721
LNEFYAHPRLQDYYV	KCNT1	371	Q5JUK3
FLNFDPPIEEFHQYY	PCYOX1	326	Q9UHG3
NYDFPPTLQDYIHRA	DDX28	471	Q9NUL7
LADFYNLYIVENPHY	DNAH12	2726	Q6ZR08
VLPNVYYEFFYHPHD	OOSP1	66	A8MZH6
VFYPRENFSHPYYLR	MYO15B	1251	Q96JP2
NEYFYSHLNNPYPSE	PBX4	226	Q9BYU1
DRYYDPNGFNAHYLR	GAL3ST1	201	Q99999
PPYNAQQDYHARSYF	C17orf98	41	A8MV24
RYLPYNQQHLYFFLI	FADS3	256	Q9Y5Q0
ENVDYCRYPEYVHPN	MEIOC	321	A2RUB1
PDHYEEAPRNYDTYT	RHBDD1	251	Q8TEB9
PCLLSEYTENYPFYH	SAXO1	31	Q8IYX7
FILREDPAYLHYYDP	PLEK	266	P08567
RAQPYDPNFYDETYD	HNRNPK	221	P61978
FDPNTREDLPYHYYD	ST8SIA3	326	O43173
FNFLNPNDPYHAYYR	SF3A1	81	Q15459
HEDYQLPYYDLVPSD	TGFBR1	421	P36897
YFRYPDAFYPQHFLD	CYP2G1P	56	Q6ZSU1
APEHYLYQRNRPVDY	CNNM1	656	Q9NRU3
RDNCPFHYNPAQYDY	THBS1	751	P07996
PEYENIRHYEEIPEY	FGD6	746	Q6ZV73
PRHYQLDQLPDYYDT	PHLPP1	1701	O60346
FRINFDHYYPVPYIQ	SETBP1	986	Q9Y6X0
QYRDHYDKLYPLRPQ	ZFHX3	2021	Q15911
FLNPRAFPEERYYSH	NAALADL1	666	Q9UQQ1
YPDYDDYRAEAFLHQ	N4BP2	1616	Q86UW6