Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR8I2 OR2F2 GPR20 GPR25 GPR173 MC4R OR2J1 GPR63 OR2F1 FZD4 FZD8 OR2A12 OR6C75 MRGPRG OR1P1 TAAR9 GPRC5D ADGRE1 FZD2 OR1L4 OR2A2

4.58e-0988410421GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR8I2 OR2F2 GPR20 GPR25 GPR173 MC4R OR2J1 GPR63 OR2F1 FZD4 FZD8 ANTXRL OR2A12 OR6C75 MRGPRG OR1P1 TAAR9 GPRC5D ADGRE1 FZD2 CTSH EPHA8 OR1L4 OR2A2

8.63e-08135310424GO:0004888
GeneOntologyMolecularFunctionWnt receptor activity

FZD4 FZD8 FZD2

8.85e-05171043GO:0042813
GeneOntologyMolecularFunctionolfactory receptor activity

OR8I2 OR2F2 OR2J1 OR2F1 OR2A12 OR6C75 OR1P1 OR1L4 OR2A2

4.21e-044311049GO:0004984
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR8I2 OR2F2 GPR20 GPR25 GPR173 MC4R OR2J1 GPR63 OR2F1 FZD4 FZD8 OR2A12 RACK1 OR6C75 MRGPRG OR1P1 TAAR9 GPRC5D ADGRE1 FZD2 CNTN2 OR1L4 OR2A2

3.51e-07139510423GO:0007186
Domain7tm_1

OR8I2 OR2F2 GPR20 GPR25 GPR173 MC4R OR2J1 GPR63 OR2F1 OR2A12 OR6C75 MRGPRG TAAR9 OR1L4 OR2A2

4.45e-0667710315PF00001
DomainG_PROTEIN_RECEP_F1_1

OR8I2 OR2F2 GPR20 GPR25 GPR173 MC4R OR2J1 GPR63 OR2F1 OR2A12 OR6C75 MRGPRG TAAR9 OR1L4 OR2A2

5.12e-0668510315PS00237
DomainG_PROTEIN_RECEP_F1_2

OR8I2 OR2F2 GPR20 GPR25 GPR173 MC4R OR2J1 GPR63 OR2F1 OR2A12 OR6C75 MRGPRG TAAR9 OR1L4 OR2A2

5.69e-0669110315PS50262
DomainGPCR_Rhodpsn

OR8I2 OR2F2 GPR20 GPR25 GPR173 MC4R OR2J1 GPR63 OR2F1 OR2A12 OR6C75 MRGPRG TAAR9 OR1L4 OR2A2

5.79e-0669210315IPR000276
Domain-

SEMA4F DYNC2I2 FBXW2 TEP1 PALB2 RACK1 TECPR2 RPTOR MAPKBP1 RMC1

1.54e-05333103102.130.10.10
DomainWD40/YVTN_repeat-like_dom

SEMA4F DYNC2I2 FBXW2 TEP1 PALB2 RACK1 TECPR2 RPTOR MAPKBP1 RMC1

1.62e-0533510310IPR015943
DomainGPCR_Rhodpsn_7TM

OR8I2 OR2F2 GPR20 GPR25 GPR173 MC4R GPR63 OR2F1 OR2A12 OR6C75 MRGPRG TAAR9 OR1L4 OR2A2

1.84e-0567010314IPR017452
DomainWD_REPEATS_1

DYNC2I2 FBXW2 TEP1 PALB2 RACK1 TECPR2 RPTOR HERC2 MAPKBP1

2.33e-052781039PS00678
DomainWD_REPEATS_2

DYNC2I2 FBXW2 TEP1 PALB2 RACK1 TECPR2 RPTOR HERC2 MAPKBP1

2.40e-052791039PS50082
DomainWD_REPEATS_REGION

DYNC2I2 FBXW2 TEP1 PALB2 RACK1 TECPR2 RPTOR HERC2 MAPKBP1

2.40e-052791039PS50294
DomainFrizzled

FZD4 FZD8 FZD2

2.60e-05111033IPR000539
DomainFrizzled

FZD4 FZD8 FZD2

2.60e-05111033PF01534
DomainFrizzled

FZD4 FZD8 FZD2

2.60e-05111033SM01330
DomainSugar_transporter_CS

SLC2A9 MFSD9 SLC17A9 SLC2A11

2.79e-05321034IPR005829
DomainMFS

SLC2A9 MFSD9 FLVCR2 SLC17A9 SLC37A4 SLC2A11

2.95e-051081036PS50850
DomainAPC_dom

APC2 APC

3.01e-0521032IPR026831
DomainAPC_N

APC2 APC

3.01e-0521032IPR032038
DomainAPC_basic_dom

APC2 APC

3.01e-0521032IPR009234
DomainApc_fam

APC2 APC

3.01e-0521032IPR026818
DomainCOX7B

COX7B COX7B2

3.01e-0521032PF05392
DomainAPC_r

APC2 APC

3.01e-0521032PF05923
DomainSAMP

APC2 APC

3.01e-0521032PF05924
DomainAPC_rpt

APC2 APC

3.01e-0521032IPR009223
DomainSAMP

APC2 APC

3.01e-0521032IPR009224
DomainCyt_c_oxidase_suVIIB

COX7B COX7B2

3.01e-0521032IPR008433
Domain-

COX7B COX7B2

3.01e-05210324.10.51.10
DomainAPC_basic

APC2 APC

3.01e-0521032PF05956
DomainCyt_c_oxidase_suVIIB_dom

COX7B COX7B2

3.01e-0521032IPR023272
DomainAPC_N_CC

APC2 APC

3.01e-0521032PF16689
DomainWD40_repeat_dom

DYNC2I2 FBXW2 TEP1 PALB2 RACK1 TECPR2 RPTOR MAPKBP1 RMC1

3.91e-052971039IPR017986
DomainFrizzled/SFRP

FZD4 FZD8 FZD2

8.66e-05161033IPR015526
DomainTECPR

TECPR2 HERC2

9.00e-0531032SM00706
DomainBeta-propeller_rpt_TECPR

TECPR2 HERC2

9.00e-0531032IPR006624
DomainMFS_dom

SLC2A9 MFSD9 FLVCR2 SLC17A9 SLC37A4 SLC2A11

9.86e-051341036IPR020846
DomainSUGAR_TRANSPORT_2

SLC2A9 SLC17A9 SLC2A11

1.05e-04171033PS00217
DomainWD40_repeat

DYNC2I2 FBXW2 TEP1 RACK1 TECPR2 RPTOR HERC2 MAPKBP1

1.31e-042721038IPR001680
DomainFRI

FZD4 FZD8 FZD2

1.73e-04201033SM00063
Domain-

GTF2IRD2B GTF2IRD2

1.79e-04410323.90.1460.10
DomainGTF2I

GTF2IRD2B GTF2IRD2

1.79e-0441032PS51139
DomainGTF2I

GTF2IRD2B GTF2IRD2

1.79e-0441032PF02946
DomainGTF2I

GTF2IRD2B GTF2IRD2

1.79e-0441032IPR004212
Domain-

FZD4 FZD8 FZD2

2.02e-042110331.10.2000.10
DomainRCC1/BLIP-II

MYCBP2 TECPR2 HERC2

2.66e-04231033IPR009091
DomainFrizzled_dom

FZD4 FZD8 FZD2

3.03e-04241033IPR020067
DomainFZ

FZD4 FZD8 FZD2

3.03e-04241033PS50038
DomainFz

FZD4 FZD8 FZD2

3.03e-04241033PF01392
DomainGPCR_2_secretin-like

FZD4 FZD8 ADGRE1 FZD2

3.36e-04601034IPR000832
DomainGPCR_2-like

FZD4 FZD8 ADGRE1 FZD2

3.36e-04601034IPR017981
DomainG_PROTEIN_RECEP_F2_4

FZD4 FZD8 ADGRE1 FZD2

3.58e-04611034PS50261
DomainAPC_su10/DOC_dom

MYCBP2 HERC2

6.21e-0471032IPR004939
DomainDOC

MYCBP2 HERC2

6.21e-0471032PS51284
DomainAPC10

MYCBP2 HERC2

6.21e-0471032SM01337
DomainANAPC10

MYCBP2 HERC2

6.21e-0471032PF03256
DomainArm

APC2 APC KPNB1

6.54e-04311033PF00514
DomainWD40

DYNC2I2 FBXW2 TEP1 RACK1 TECPR2 RPTOR MAPKBP1

7.11e-042681037SM00320
DomainMFS_1

MFSD9 FLVCR2 SLC17A9 SLC37A4

8.67e-04771034PF07690
DomainMFS

MFSD9 FLVCR2 SLC17A9 SLC37A4

8.67e-04771034IPR011701
DomainARM

APC2 APC KPNB1

1.39e-03401033SM00185
DomainOlfact_rcpt

OR8I2 OR2F2 OR2J1 OR2F1 OR2A12 OR6C75 OR1L4 OR2A2

1.49e-033931038IPR000725
DomainGrowth_fac_rcpt_

FRAS1 FBXL19 DLL1 ADGRE1 TNXB

1.73e-031561035IPR009030
Domainfn3

LRFN1 USH2A TNXB CNTN2 EPHA8

2.04e-031621035PF00041
DomainArmadillo

APC2 APC KPNB1

2.21e-03471033IPR000225
DomainSugar/inositol_transpt

SLC2A9 SLC2A11

2.62e-03141032IPR003663
DomainWD40

DYNC2I2 FBXW2 TEP1 RACK1 RPTOR MAPKBP1

3.13e-032591036PF00400
DomainFN3

LRFN1 USH2A TNXB CNTN2 EPHA8

3.62e-031851035SM00060
DomainARM-like

APC2 APC HSF2BP USP9Y RPTOR KPNB1

3.83e-032701036IPR011989
DomainAcyl_Trfase/lysoPLipase

PNPLA1 PLA2G4F

3.88e-03171032IPR016035
DomainFN3

LRFN1 USH2A TNXB CNTN2 EPHA8

4.92e-031991035PS50853
DomainRCC1

MYCBP2 HERC2

5.36e-03201032PF00415
PathwayKEGG_BASAL_CELL_CARCINOMA

WNT8A APC2 APC FZD4 FZD8 FZD2

4.36e-0755756M17807
PathwayKEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

WNT8A APC FZD4 FZD8 FZD2

3.85e-0645755M47412
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY

WNT8A APC FZD4 FZD8 FZD2

4.31e-0646755M47409
PathwayWNT_SIGNALING

WNT8A APC FBXW2 FZD4 FZD8 FZD2

7.58e-0689756M5493
PathwayKEGG_WNT_SIGNALING_PATHWAY

PSEN1 WNT8A APC2 APC FZD4 FZD8 FZD2

1.52e-05151757M19428
PathwayBIOCARTA_PS1_PATHWAY

PSEN1 APC DLL1

5.05e-0514753MM1459
PathwayBIOCARTA_PS1_PATHWAY

PSEN1 APC DLL1

5.05e-0514753M16173
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_SOST_LRP4

FZD4 FZD8 FZD2

5.05e-0514753M47834
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

OR2F2 GPR20 GPR25 GPR173 MC4R OR2J1 GPR63 OR2F1

6.98e-05260758M39397
PathwayKEGG_MEDICUS_REFERENCE_WNT5A_ROR_SIGNALING_PATHWAY

FZD4 FZD8 FZD2

7.71e-0516753M47823
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

APC FZD4 FZD8 FZD2

8.54e-0544754MM15878
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_LGR_RSPO

FZD4 FZD8 FZD2

1.32e-0419753M47833
PathwayREACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS

WNT8A FZD4 FZD8 ADGRE1 FZD2

1.41e-0494755M797
PathwayWP_GPCRS_ODORANT

GPR20 GPR25 GPR173 GPR63 MRGPRG TAAR9

1.85e-04157756MM15872
PathwayWP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY

APC FBXW2 FZD4 FZD8 FZD2

1.98e-04101755MM15829
PathwayWP_WNT_SIGNALING_AND_PLURIPOTENCY

APC FBXW2 FZD4 FZD8 FZD2

1.98e-04101755M39387
PathwayWP_WNT_SIGNALING

APC FBXW2 FZD8 FZD2

3.07e-0461754MM15893
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR8I2 OR2F2 OR2J1 OR2F1 OR2A12 OR6C75 OR1P1 OR1L4 OR2A2

3.55e-04417759M4072
PathwayWP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES

WNT8A DLL1 FZD4 FZD8 FZD2

4.08e-04118755M39852
PathwayBIOCARTA_NOTCH_PATHWAY

PSEN1 DLL1

4.13e-046752MM1584
PathwayBIOCARTA_NOTCH_PATHWAY

PSEN1 DLL1

4.13e-046752M22074
PathwayWP_PHYSICOCHEMICAL_FEATURES_AND_TOXICITYASSOCIATED_PATHWAYS

APC FZD4 FZD8 FZD2

4.15e-0466754M39642
PathwayPID_WNT_SIGNALING_PATHWAY

FZD4 FZD8 FZD2

4.31e-0428753M77
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

WNT8A APC FZD2

5.84e-0431753M27400
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

WNT8A APC FZD2

5.84e-0431753MM15154
PathwayREACTOME_SIGNALING_BY_RNF43_MUTANTS

FZD4 FZD8

7.66e-048752M27433
PathwayREACTOME_SIGNALING_BY_WNT_IN_CANCER

APC FZD4 FZD8

7.69e-0434753M27405
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

FZD4 FZD8 FZD2

9.10e-0436753M39699
PathwayWP_POLYCYSTIC_KIDNEY_DISEASE_PATHWAY

WNT8A FZD4 FZD8 FZD2

1.08e-0385754M48315
PathwayWP_BREAST_CANCER_PATHWAY

APC2 APC DLL1 FZD8 FZD2

1.36e-03154755M39739
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

WNT8A APC FZD4 FZD8 FZD2

1.52e-03158755MM14791
PathwayWP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER

WNT8A DLL1 FZD4 FZD8 FZD2

1.66e-03161755M39770
PathwayWP_NOTCH_SIGNALING_WP268

PSEN1 RBPJL DLL1

1.75e-0345753M39571
PathwayWP_LNCRNA_IN_CANONICAL_WNT_SIGNALING_AND_COLORECTAL_CANCER

APC2 APC FZD8 FZD2

1.83e-0398754M39731
PathwayPID_PS1_PATHWAY

PSEN1 APC DLL1

1.86e-0346753M70
PathwayWP_NOTCH_SIGNALING_PATHWAY

PSEN1 RBPJL DLL1

1.86e-0346753MM15971
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

PSEN1 RBPJL DLL1

1.98e-0347753M7946
PathwayKEGG_MELANOGENESIS

WNT8A FZD4 FZD8 FZD2

2.04e-03101754M7761
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY

RBPJL DLL1

2.10e-0313752M47423
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382

PSEN1 RBPJL

2.10e-0313752M47534
PathwayWP_WNT_SIGNALING_PATHWAY

APC FZD4 FZD8 FZD2

2.79e-03110754MM15977
PathwayWP_GPCRS_NONODORANT

MC4R FZD4 FZD8 GPRC5D ADGRE1 FZD2

2.89e-03266756MM15843
Pubmed

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

WNT8A FZD4 FZD8 FZD2

1.95e-0717107428733458
Pubmed

Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.

WNT8A APC FBXW2 FZD4 FZD8 FZD2

3.72e-0790107619515997
Pubmed

A role for Wnt/beta-catenin signaling in lens epithelial differentiation.

WNT8A FZD4 FZD8 FZD2

1.02e-0625107412812787
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR8I2 OR2F2 OR2J1 OR2F1 OR2A12 OR6C75 OR1P1 OR1L4 OR2A2

1.14e-06340107911875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR8I2 OR2F2 OR2J1 OR2F1 OR2A12 OR6C75 OR1P1 OR1L4 OR2A2

1.14e-06340107911802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR8I2 OR2F2 OR2J1 OR2F1 OR2A12 OR6C75 OR1P1 OR1L4 OR2A2

1.22e-06343107932295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR8I2 OR2F2 OR2J1 OR2F1 OR2A12 OR6C75 OR1P1 OR1L4 OR2A2

1.31e-06346107914611657
Pubmed

PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.

SEMA4F LRFN1 FZD4 FZD8 FZD2 EPHA8

1.75e-06117107617145500
Pubmed

3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).

WNT8A FZD4 FZD8 FZD2

1.90e-0629107418364260
Pubmed

A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.

APC FZD4 FZD2

2.35e-06910739707618
Pubmed

Expression of Frizzled genes in developing and postnatal hair follicles.

FZD4 FZD8 FZD2

3.34e-0610107315245425
Pubmed

Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis.

FZD4 FZD8 FZD2

3.34e-0610107317532316
Pubmed

Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.

FZD4 FZD8 FZD2

4.59e-0611107324860427
Pubmed

Molecular determinants of WNT9b responsiveness in nephron progenitor cells.

FZD4 FZD8 FZD2

4.59e-0611107330978219
Pubmed

Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain.

FZD4 FZD8 FZD2

4.59e-0611107317582687
Pubmed

Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling.

FZD4 FZD8 FZD2

4.59e-0611107317576136
Pubmed

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.

WNT8A FZD4 FZD8 FZD2

5.17e-0637107415342465
Pubmed

Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis.

WNT8A FZD4 FZD8 FZD2

5.17e-0637107418800919
Pubmed

Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals.

WNT8A FZD4 FZD8 FZD2

5.77e-0638107421041481
Pubmed

Tissue-specific requirements of beta-catenin in external genitalia development.

WNT8A FZD4 FZD8 FZD2

5.77e-0638107418635608
Pubmed

Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.

APC2 APC

9.38e-062107227694902
Pubmed

Frizzled-4 is required for normal bone acquisition despite compensation by Frizzled-8.

FZD4 FZD8

9.38e-062107231985040
Pubmed

A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity.

SLC2A9 SLC2A11

9.38e-062107217710649
Pubmed

APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression.

APC2 APC

9.38e-062107231291912
Pubmed

RACK1 affects glioma cell growth and differentiation through the CNTN2-mediated RTK/Ras/MAPK pathway.

RACK1 CNTN2

9.38e-062107226718491
Pubmed

Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.

GTF2IRD2B GTF2IRD2

9.38e-062107215388857
Pubmed

Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.

WNT8A FZD4 FZD8 FZD2

1.36e-0547107428813421
Pubmed

Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.

WNT8A FZD4 FZD8 FZD2

1.36e-0547107433141892
Pubmed

Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells.

WNT8A FZD4 FZD8 FZD2

1.61e-0549107419562671
Pubmed

Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling.

DLL1 FZD4 FZD8 FZD2

1.75e-0550107427510977
Pubmed

Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome.

GTF2IRD2B GTF2IRD2

2.81e-053107215100712
Pubmed

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase.

PSEN1 DLL1

2.81e-053107212794186
Pubmed

The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage.

PSEN1 DLL1

2.81e-053107212551931
Pubmed

RACK1 (receptor for activated C-kinase 1) interacts with FBW2 (F-box and WD-repeat domain-containing 2) to up-regulate GCM1 (glial cell missing 1) stability and placental cell migration and invasion.

FBXW2 RACK1

2.81e-053107223651062
Pubmed

Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation.

APC2 APC

2.81e-053107223840886
Pubmed

Differential regulation of microtubule severing by APC underlies distinct patterns of projection neuron and interneuron migration.

APC2 APC CNTN2

3.11e-0520107325535916
Pubmed

Mesenchymal Hox6 function is required for mouse pancreatic endocrine cell differentiation.

DLL1 FZD4 FZD8 FZD2

3.38e-0559107426450967
Pubmed

Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.

FZD4 FZD8 FZD2

4.18e-0522107317064353
Pubmed

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.

FZD4 FZD8 FZD2

5.47e-052410739096311
Pubmed

A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.

FZD4 FZD8 FZD2

5.47e-052410738626800
Pubmed

A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls.

FRAS1 SLC2A9

5.60e-054107223703922
Pubmed

TFII-I gene family during tooth development: candidate genes for tooth anomalies in Williams syndrome.

GTF2IRD2B GTF2IRD2

5.60e-054107217823943
Pubmed

Evolution of general transcription factors.

GTF2IRD2B GTF2IRD2

5.60e-054107223229069
Pubmed

GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members.

GTF2IRD2B GTF2IRD2

5.60e-054107222899722
Pubmed

Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation.

FZD4 FZD8

5.60e-054107216115200
Pubmed

Haploinsufficiency of Gtf2i, a gene deleted in Williams Syndrome, leads to increases in social interactions.

GTF2IRD2B GTF2IRD2

5.60e-054107221328569
Pubmed

Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway.

APC CPS1

5.60e-054107229426940
Pubmed

A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction.

APC2 APC

5.60e-054107226393419
Pubmed

Hedgehog/Patched-associated rhabdomyosarcoma formation from delta1-expressing mesodermal cells.

APC DLL1

5.60e-054107226387541
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR8I2 OR2F1 OR2A12 OR1P1 OR1L4 OR2A2

6.20e-05219107612213199
Pubmed

Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion.

APC DLL1

9.32e-055107231843916
Pubmed

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development.

PSEN1 DLL1

9.32e-055107215634781
Pubmed

Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner.

FZD4 FZD8

9.32e-055107210395542
Pubmed

The G protein-coupled receptor repertoires of human and mouse.

GPR20 GPR173 MRGPRG TAAR9

1.07e-0479107412679517
Pubmed

The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.

APC2 APC

1.40e-046107210074433
Pubmed

Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling.

FZD4 FZD2

1.40e-046107220802536
Pubmed

Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage.

APC ADGRE1

1.40e-046107225393502
Pubmed

CDK5 activator protein p25 preferentially binds and activates GSK3β.

PSEN1 APC

1.40e-046107225331900
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SEMA4F FRAS1 LRFN1 MYCBP2 ZNF395 FBXL19 DLL1 TEP1 RPTOR ZFYVE26 HERC2 MAPKBP1

1.54e-0411051071235748872
Pubmed

Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.

FZD4 FZD8 FZD2

1.88e-0436107324151333
Pubmed

Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation.

FZD4 FZD8 FZD2

1.88e-0436107312412008
Pubmed

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm.

PSEN1 DLL1

1.95e-04710729153393
Pubmed

Presenilin-1 regulates neuronal differentiation during neurogenesis.

PSEN1 DLL1

1.95e-047107210821758
Pubmed

The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities.

HERC2P3 HERC2

1.95e-04710729949213
Pubmed

Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites.

PSEN1 DLL1

1.95e-047107212900443
Pubmed

MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap.

FZD4 FZD8

1.95e-047107215195140
Pubmed

Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation.

PSEN1 DLL1

1.95e-047107215866159
Pubmed

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization.

APC2 APC

1.95e-047107210330403
Pubmed

Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).

FZD4 FZD8

1.95e-047107215370539
Pubmed

Regulator of G protein signaling 12 drives inflammatory arthritis by activating synovial fibroblasts through MYCBP2/KIF2A signaling.

MYCBP2 HERC2

1.95e-047107236700049
Pubmed

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice.

PSEN1 DLL1

1.95e-047107211567612
Pubmed

Integrated analysis of Wnt signalling system component gene expression.

WNT8A FZD4 FZD8

2.04e-0437107335831952
Pubmed

The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.

DLL1 FZD2

2.59e-048107212839624
Pubmed

Mesp2 initiates somite segmentation through the Notch signalling pathway.

PSEN1 DLL1

2.59e-048107210932180
Pubmed

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair.

FZD4 FZD8

2.59e-048107215035989
Pubmed

Differential expression of the Wnt putative receptors Frizzled during mouse somitogenesis.

FZD4 FZD8

2.59e-048107210559494
Pubmed

Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene.

APC CNTN2

2.59e-04810729126737
Pubmed

Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.

FZD4 FZD2

2.59e-048107219388021
Pubmed

Mice lacking both presenilin genes exhibit early embryonic patterning defects.

PSEN1 DLL1

2.59e-048107210557208
Pubmed

The human olfactory receptor gene family.

OR8I2 OR2F2 OR2J1 OR2F1 OR2A12 OR1P1 OR1L4 OR2A2

2.76e-04541107814983052
Pubmed

HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis.

HSF2BP PALB2

3.33e-049107231242413
Pubmed

Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells.

PSEN1 DLL1

3.33e-049107211937492
Pubmed

Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta.

APC2 APC

3.33e-04910729601641
Pubmed

Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.

FZD4 FZD2

3.33e-049107212067714
Pubmed

Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer.

VTCN1 APC

3.33e-049107235364006
Pubmed

Genetic evidence that SOST inhibits WNT signaling in the limb.

FBXW2 FZD4 FZD2

3.66e-0445107320359476
Pubmed

Differentiation of the mononuclear phagocyte system during mouse embryogenesis: the role of transcription factor PU.1.

PSEN1 ADGRE1

4.15e-0410107210381505
Pubmed

The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite.

PSEN1 DLL1

4.15e-0410107217360776
Pubmed

Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates.

PSEN1 DLL1

4.15e-0410107224715457
Pubmed

Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.

FZD4 FZD8 FZD2

4.16e-0447107318351675
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

PFKM THOC2 RACK1 RPTOR SIPA1L1

4.73e-04208107533230847
Pubmed

WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth.

FZD4 FZD8 FZD2

4.99e-0450107318351662
Pubmed

A forward genetic screen in mice identifies mutants with abnormal cortical patterning.

MYCBP2 CNTN2

5.06e-0411107223968836
Pubmed

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.

FZD4 FZD8

5.06e-0411107222575959
Pubmed

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.

APC CPS1

5.06e-0411107220084116
Pubmed

Evidence that descending cortical axons are essential for thalamocortical axons to cross the pallial-subpallial boundary in the embryonic forebrain.

APC CNTN2

5.06e-0411107222412988
Pubmed

Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation.

PSEN1 DLL1

6.07e-0412107217306789
Pubmed

Molecular Fingerprint and Developmental Regulation of the Tegmental GABAergic and Glutamatergic Neurons Derived from the Anterior Hindbrain.

PSEN1 DLL1 CNTN2

6.97e-0456107333053343
Pubmed

Genome-wide association analysis identifies three psoriasis susceptibility loci.

FBXL19 PRSS53

7.15e-0413107220953189
Pubmed

The role of presenilin 1 during somite segmentation.

PSEN1 DLL1

7.15e-0413107211262239
Cytoband7q35

OR2F2 OR2F1 OR2A12 OR2A2

8.68e-065510747q35
CytobandEnsembl 112 genes in cytogenetic band chr7q35

OR2F2 OR2F1 OR2A12 OR2A2

1.80e-05661074chr7q35
GeneFamilyG protein-coupled receptors, Class F frizzled

FZD4 FZD8 FZD2

1.06e-0511743286
GeneFamilyG protein-coupled receptors, Class A orphans

GPR20 GPR25 GPR173 GPR63 MRGPRG

1.68e-0578745262
GeneFamilyOlfactory receptors, family 2

OR2F2 OR2J1 OR2F1 OR2A12 OR2A2

9.97e-05113745149
GeneFamilyFibronectin type III domain containing

LRFN1 USH2A TNXB CNTN2 EPHA8

5.02e-04160745555
GeneFamilyWD repeat domain containing

DYNC2I2 FBXW2 TEP1 RACK1 RPTOR MAPKBP1

7.11e-04262746362
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

APC2 APC KPNB1

7.22e-0443743409
GeneFamilyMitochondrial complex IV: cytochrome c oxidase subunits

COX7B COX7B2

2.70e-0319742643
GeneFamilySolute carriers

SLC2A9 FLVCR2 SLC7A4 SLC17A9 SLC37A4 SLC2A11

5.56e-03395746752
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage_4|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

TMEM250 SEMA4F EBLN2 GARIN2 TECPR2 MAPKBP1

8.81e-0713410769e12aac8f42790c2f104dfd61c87aa99fc7925f1
ToppCellPND07-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CLEC6A SLC2A9 TEP1 ADGRE1 CTSH ALOX5AP

1.34e-061441076f5d0d0564fcbec8a5d87119e0807b619faa77b0f
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RBPJL MFSD9 GDPD2 SLC17A9 MAPKBP1 CTSH

2.66e-0616210768e0f03fcc25b2ea777e8478fbf771699cf93719c
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RBPJL MFSD9 GDPD2 SLC17A9 MAPKBP1 CTSH

2.66e-061621076e0417f1242edf71934fe62bccc55c4678f7ff4ac
ToppCellE16.5-samps-Epithelial-Alveolar_epithelial_precursor-Noncycling_AT2_Precursor|E16.5-samps / Age Group, Lineage, Cell class and subclass

SEMA4F RBPJL CPS1 PLA2G4F CTSH

3.64e-0515510759cad73d0b8ead289e1073d1a2e00bbeb1228308c
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Myeloid-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLEC6A PCDHA7 ADGRE1 CTSH ALOX5AP

3.87e-051571075c8f516d3f5622202d3f8514f68614cd86ea3f667
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Myeloid|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLEC6A PCDHA7 ADGRE1 CTSH ALOX5AP

3.87e-0515710754862a11ab8df27d26b4f1c1785e544a2d5b6db6e
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Myeloid-macrophage|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLEC6A PCDHA7 ADGRE1 CTSH ALOX5AP

3.87e-051571075a0ec1628ce29841889f1d9d4ee9422921af7b0b5
ToppCell343B-Myeloid-Dendritic-cDC_proliferating_2|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

CAPN12 MAP3K6 FZD8 PASK SLC37A4

4.77e-051641075d7053de88ef8e42cac6726a40e72f212659ee034
ToppCellfacs-Liver-Hepatocytes-24m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLEC6A PALB2 ADGRE1 CTSH ALOX5AP

5.05e-05166107503a47b8687f54955e84df1edcb230db332c4ca8f
ToppCellfacs-Skin-Anagen-24m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GDPD2 PNPLA1 PRSS53 SIPA1L1 PLA2G4F

5.20e-05167107502c89069dcd0e87f7502e32b14e7cbd3cab81a09
ToppCellP03-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SEMA4F RBPJL GDPD2 MLC1 CTSH

5.65e-0517010753fd37e9b377d6485cea1262c31a8507d18a78514
ToppCelldroplet-Marrow-nan-3m-Myeloid-monocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYADM MYCBP2 TEP1 ADGRE1 CTSH

5.81e-051711075992df143d76f9e7fb1997a8996f61e941f0f9d4f
ToppCellE18.5-samps-Epithelial-Alveolar_epithelial-AT2|E18.5-samps / Age Group, Lineage, Cell class and subclass

RBPJL GDPD2 MLC1 PLA2G4F CTSH

6.14e-051731075f6e36ea98a9c669ff393d141455aaecef083f738
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Interstitial_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLEC6A ZNF395 PNPLA1 ADGRE1 CATSPERG

6.14e-05173107526bba58f9fb215d1d155504906cd77e8774f6936
ToppCelldroplet-Lung-LUNG-1m-Myeloid-lung_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLEC6A ZNF395 PNPLA1 ADGRE1 CATSPERG

6.14e-05173107569b404e92aad3e6dff67e75466f073f20a71f13f
ToppCellImmune_cells-Monocytes|Immune_cells / Lineage and Cell class

MYADM TEP1 ADGRE1 CTSH ALOX5AP

6.14e-0517310753eced40a65453a023a1673658592e7e2a099119b
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLEC6A TEP1 ADGRE1 CTSH ALOX5AP

6.31e-0517410753533a47885af453d97739e5576e989d93d31be32
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLEC6A TEP1 ADGRE1 CTSH ALOX5AP

6.31e-051741075b487c5c46f074a69b9526a2c72daf218f66aa44b
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR20 RBPJL GPR63 FZD2 TNXB

6.49e-05175107559249c9e83952d7277010e7be3c779e26399eb5d
ToppCelldroplet-Heart-HEART-1m-Hematologic|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLEC6A TEP1 ADGRE1 CTSH ALOX5AP

6.49e-05175107543b9cfd7c47d57244565c641e57f3256b5900804
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR20 RBPJL GPR63 FZD2 TNXB

6.49e-051751075b35cc1357495f2a03a6500f807c6e6f8c877734d
ToppCelldroplet-Heart-HEART-1m-Hematologic-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLEC6A TEP1 ADGRE1 CTSH ALOX5AP

6.49e-051751075a2fed97cf8d28f9936fe791e5e8c43d2430330c9
ToppCelldroplet-Heart-HEART-1m-Hematologic-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLEC6A TEP1 ADGRE1 CTSH ALOX5AP

6.66e-0517610751df640f88667e2dad30e65279d6d33bba75024c1
ToppCellfacs-Lung-Endomucin-24m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRFN1 CLEC6A TEP1 PASK ALOX5AP

7.22e-051791075e520eadde4f1b7fb868dbbe94c4d62b3776c55eb
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+-Alveolar_macrophage_CCL3+_L.1.0.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CLEC6A FLVCR2 TEP1 ZFYVE26 ALOX5AP

7.61e-051811075a8d4b2340d99734bf9379b467fb481c598b9b4fb
ToppCelldroplet-Lung-LUNG-1m-Epithelial-type_II_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBPJL GDPD2 SLC7A4 MLC1 PLA2G4F

7.81e-051821075c1e0be27064e14043b78ae501b02d4e9542267a3
ToppCelldroplet-Lung-LUNG-1m-Epithelial-Alveolar_Epithelial_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBPJL GDPD2 SLC7A4 MLC1 PLA2G4F

7.81e-0518210753c9b4869d357884ae4bcd22a9872faf83a5cfc6d
ToppCellPND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEMA4F RBPJL GDPD2 MLC1 CTSH

8.43e-051851075fd51fef8c69e34c72017d8371ab0a0d7be5701f2
ToppCellPND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEMA4F RBPJL GDPD2 MLC1 CTSH

8.43e-051851075bea26e369ae91006052b973cd89b4c49afa9e553
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEMA4F RBPJL GDPD2 MLC1 CTSH

8.87e-0518710756ab51e17a7782c2ae6394cad813dc3a2cde70c89
ToppCellfacs-Lung-18m-Epithelial-alveolar_epithelial-type_II_pneumocyte-type_2_alveolar_epithelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEMA4F RBPJL SLC7A4 MLC1 CTSH

8.87e-051871075a5318c888b334e8695f38971a7d100b93cdaf04b
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEMA4F RBPJL GDPD2 MLC1 CTSH

8.87e-051871075e176b5b051690f840f3b12c8f7c4cc10cbe2bbae
ToppCellfacs-Lung-18m-Epithelial-alveolar_epithelial-type_II_pneumocyte|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEMA4F RBPJL SLC7A4 MLC1 CTSH

8.87e-05187107564ba0df991eab8b2632751805d758c5f2711f4d7
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FRAS1 CWH43 VTCN1 PLA2G4F CTSH

8.87e-051871075b7689e7f6511920cd2beff27389555fddf685f61
ToppCell368C-Epithelial_cells-Epithelial-I_(AT1)-|368C / Donor, Lineage, Cell class and subclass (all cells)

TMEM250 DYNC2I2 TEP1 FZD8 TMC5

9.09e-051881075c74771584b3ba9561a99a54bf55a9203ddf8eff8
ToppCell368C-Epithelial_cells-Epithelial-I_(AT1)|368C / Donor, Lineage, Cell class and subclass (all cells)

TMEM250 DYNC2I2 TEP1 FZD8 TMC5

9.09e-0518810759155b9a92496e75646778c025b02947e9e9ec73a
ToppCellE18.5|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RBPJL COX7B GDPD2 RACK1 CTSH

9.56e-051901075fe9678be25e29a09c0b9ac59da4ee3a29f22dde1
ToppCellCaecum-T_cell-Tfh|T_cell / Region, Cell class and subclass

EBLN2 CPS1 PASK GTF2IRD2B ADGRE1

1.11e-041961075fe2ee5788028e6b671674f0cc50e2b6379f50976
Diseasefamilial adenomatous polyposis 1 (implicated_via_orthology)

APC2 APC

1.23e-0521042DOID:0080409 (implicated_via_orthology)
DiseaseMorphological abnormality of the central nervous system

APC2 DLL1

1.23e-0521042C4021765
DiseaseMAJOR AFFECTIVE DISORDER 2

FZD4 MLC1 GPRC5D

2.79e-05171043C1839839
Diseasehistidine measurement

SLC2A9 PFKM CPS1 ARL6IP6

8.87e-05661044EFO_0009769
Diseasecongenital disorder of glycosylation type II (is_implicated_in)

EDEM3 SLC37A4

2.55e-0471042DOID:0050571 (is_implicated_in)
DiseaseGlycogen storage disease

PFKM SLC37A4

1.62e-03171042cv:C0017919
Diseasepentachlorophenol measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022071
Diseaseparathion measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022070
Diseasepotassium chromate measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022072
Diseasemercuric chloride measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022068
Diseaseheptachlor epoxide measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022067
Diseasemethoxychlor measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022069
Disease4,6-dinitro-o-cresol measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022053
Disease2,4,5-trichlorophenol measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022052
Diseaseazinphos methyl measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022055
Diseasealdrin measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022054
Diseasedicofol measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022060
Diseasedisulfoton measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022062
Diseasedieldrin measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022061
Diseaseendrin measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022064
Diseaseendosulfan measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022063
Diseaseheptachlor measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022066
Diseaseethion measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022065
Diseasechlorpyrifos measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022057
Diseasecadmium chloride measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022056
Diseasediazinon measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022059
Diseasedibutyl phthalate measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0022058
Diseaseenvironmental exposure measurement

SLC2A9 RPTOR USH2A

2.21e-03731043EFO_0008360
Diseaseserum homoarginine measurement

CPS1 ALOX5AP

2.24e-03201042EFO_0005421
DiseaseDDT metabolite measurement

SLC2A9 RPTOR USH2A

2.30e-03741043EFO_0007886
Diseasealcohol consumption measurement, high density lipoprotein cholesterol measurement

MC4R CPS1 RBM5 KPNB1

2.63e-031621044EFO_0004612, EFO_0007878
DiseaseSplenomegaly

PSEN1 APC

2.71e-03221042C0038002
Diseasealcohol drinking, high density lipoprotein cholesterol measurement

MC4R CPS1 RBM5 KPNB1

3.00e-031681044EFO_0004329, EFO_0004612
Diseasenicotine dependence symptom count

MYCBP2 RPTOR MRGPRG DLEC1 TMC5

3.43e-032851045EFO_0009262

Protein segments in the cluster

PeptideGeneStartEntry
TFLAVLWSAGLLCSQ

ALOX5AP

66

P20292
FSLVELSIDSCWVGS

CATSPERG

271

Q6ZRH7
VSITSTTCGIFRNWL

ANTXRL

341

A6NF34
ASWDACVVASAVLVT

CATSPERE

241

Q5SY80
CAFVWLAAGAVTLSV

GPR20

171

Q99678
RWGLTIATCLAFVNS

GPR25

286

O00155
SAFVSCGARVSSWLN

SLC7A4

181

O43246
VLASGATFCIVTWTY

COX7B

41

P24311
QELVLSGCSWLSVSA

FBXL19

511

Q6PCT2
SSCWTIIGTESVEFS

RBPJL

356

Q9UBG7
CTSLAWSADGQTLFA

RACK1

286

P63244
IGWLLTTCTSNVAAS

INTS3

376

Q68E01
KPTLVCSSAVGSWSF

PCDHA7

736

Q9UN72
SLISVWVISSLAFCD

OR8I2

156

Q8N0Y5
TVLASTCWIFSFLLA

OR2A12

141

Q8NGT7
FCRLLAAASWVSGFT

OR2J1

141

Q9GZK6
RASVWVFCTISGLIT

PASK

336

Q96RG2
SARICALASWLGSFQ

LRRTM2

316

O43300
GTDLSTFASVWCATR

FRAS1

2821

Q86XX4
LQLFSSTLVGCWSDV

MFSD9

91

Q8NBP5
CGSSHSVAWTTVDVA

HERC2

3316

O95714
LGSARACLAFTSTEW

LRFN1

751

Q9P244
AAFCLVSATSVWTAG

EDEM3

26

Q9BZQ6
ALSSLAWTSTCFQDF

C20orf203

151

Q8NBC4
SISWNSTGSVVACAY

DYNC2I2

166

Q96EX3
SSWTFPVASICGVSA

MAP3K6

566

O95382
ALVTSLSCGADWVFI

PFKM

216

P08237
WTSVFLDNASGCSLT

ERFE

326

Q4G0M1
LISCNAESAIGWISS

EBLN2

231

Q6P2I7
WSVLCCASTFFTVTT

FZD2

251

Q14332
AVLASGTAFCVATWV

COX7B2

41

Q8TF08
CAFWTDAITISTFSG

PNPLA1

181

Q8N8W4
STCVAFSLVASVGAW

MYADM

46

Q96S97
FSLLWCAGVDSVTTN

GDPD2

456

Q9HCC8
CARLAITSWVSGFIS

OR2F1

141

Q13607
CARLAITSWVSGSIN

OR2F2

141

O95006
LSGVSGSTWCISTLY

PLA2G4F

391

Q68DD2
FSVASTAIAAAQWSS

RBM5

331

P52756
TILVLTSWSCGFALS

OR2A2

141

Q6IF42
TSWSCGFALSLVHEI

OR2A2

146

Q6IF42
TAGVVLFVWVTCCST

MRGPRG

176

Q86SM5
HCAAAILTSGTIAIW

PALB2

1126

Q86YC2
WASLCFISTAFTVLT

FZD4

226

Q9ULV1
IGLWSVLCFVSTFAT

FZD8

281

Q9H461
AFWVAEVICAASTAA

SLC37A4

396

O43826
SHSLTIVSNACGTLW

APC2

636

O95996
IGSSVEFDWCAVSSI

CPS1

986

P31327
SLGNCWFLAAAASLT

CAPN12

101

Q6ZSI9
SLMTCWGSIFTVALC

SLC2A11

346

Q9BYW1
WGSIFTVALCLQSSF

SLC2A11

351

Q9BYW1
SWVLTAAHCISSSGI

CELA2B

66

P08218
CVSFSWTTILCIAIG

GPRC5D

121

Q9NZD1
VLSALLCQVWSSGVF

DLL1

11

O00548
ALWVVTAAAAAATCV

EPHA8

11

P29322
AVALVSSSAWSSALG

CNTN2

16

Q02246
CWTFSTTGALESAIA

CTSH

141

P09668
IASVWFGANEVSTAC

FLVCR2

201

Q9UPI3
VASNVCWAFSSLAEA

KPNB1

466

Q14974
GSSWTFSALSCKIVA

GPR173

86

Q9NS66
SCIWAACTVSGILFI

MC4R

171

P32245
VSGDSCIFVWRLSSE

MAPKBP1

721

O60336
QGSFLGSLWCSVTSV

ELSPBP1

91

Q96BH3
DWSCSLLVASLAGAF

SLC2A9

51

Q9NRM0
KVLIAVSWATSFCVA

GPR63

196

Q9BZJ6
VSWATSFCVAFPLAV

GPR63

201

Q9BZJ6
FCIDWSKLVSVASTG

GTF2IRD2

606

Q86UP8
FCINWSRLVSVASTG

GTF2IRD2B

606

Q6EKJ0
ADFTVKVWALSAGTC

FBXW2

246

Q9UKT8
WVALGLSLTCTSAFS

LHFPL7

6

Q6ICI0
QLSTSWVDFGTCFVS

DLEC1

1636

Q9Y238
QILWCFTAFTTAASA

CRLS1

271

Q9UJA2
TRVCTLLVFSSWLAG

OR6C75

136

A6NL08
ITLAVTSWTCGSLLA

OR2A1;

141

Q8NGT9
TSWTCGSLLALAHVV

OR2A1;

146

Q8NGT9
WKAFSTCGSHLTVVV

OR1L4

236

Q8NGR5
AFLVTACWTLTSLLA

OR1P1

156

Q8NH06
GTSWVCRQCVFAIAT

PHF1

131

O43189
WAAAVSGCVFAIFTA

CWH43

281

Q9H720
RANWVTVGICFSSST

GARIN2

66

Q8N9W8
AACTLLWGVSSSEEV

HSF2BP

126

O75031
ACTTLGCASSDWTFI

USH2A

4611

O75445
AFTVGSKCVVWSSLR

TDRD6

2026

O60522
SSQWEGATISAVCAF

SEMA4F

331

O95754
SGDWNTTIACFVAIL

PSEN1

401

P49768
VSVSGICIVLSWFFS

TAAR9

146

Q96RI9
LTWLCICSGFVTAVN

PIGF

41

Q07326
VFNCSCRDVIGWTST

SIPA1L1

896

O43166
VWAAVVSQLSAACSF

SLC17A9

241

Q9BYT1
TTGSWTCLFNLVAII

SLC17A9

396

Q9BYT1
ALSCACLFSLVASWG

MYCBP2

276

O75592
SWCTLGFVQSIALTL

HERC2P3

736

Q9BVR0
ISATVQTGFCDWSAR

RPTOR

951

Q8N122
GLVAALTLSACWDSF

ABHD1

221

Q96SE0
RWTSFGCVILEASET

ADGRE1

561

Q14246
LTAGFSCCSFSWTVT

ARL6IP6

161

Q8N6S5
SHSLTIVSNACGTLW

APC

671

P25054
WSVAGISIALLSACF

CLEC6A

21

Q6EIG7
ICSGSLVADTWVLTA

PRSS53

61

Q2L4Q9
SSWLQSLASFCGAVF

THOC2

636

Q8NI27
SSFLCASSDGILWNL

TEP1

2476

Q99973
ANILGFCWTSSTEIV

RMC1

111

Q96DM3
SCSLFTAALWGALAA

TMEM250

61

H0YL14
AAVTSDSVGLSWTVA

TNXB

3271

P22105
TSVSWAAAPSAACSL

ZNF395

426

Q9H8N7
VSCFTVTASDELWAV

TECPR2

1356

O15040
IIWASACGALGLVFS

USP9Y

1246

O00507
LSFTCFCLSNWTSGA

nan

56

Q6ZWC4
WFLCSSVALALGALT

ZDHHC16

271

Q969W1
VAWVVSTGVAIACCA

TMC5

621

Q6UXY8
LGICCAAFSASAWSV

WNT8A

11

Q9H1J5
SLAVNLCGWASLSTV

ZFYVE26

1386

Q68DK2
SKASLCVSSFFAISW

VTCN1

256

Q7Z7D3
VSTFAVTTTCLIWFG

MLC1

116

Q15049
SWVCVLVGSFSASLA

LEG1

6

Q6P5S2
VSIICWASEGISSNL

IGKV1D-42

41

A0A075B6H8