Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphorbol ester receptor activity

UNC13B UNC13C

4.88e-0521402GO:0001565
GeneOntologyMolecularFunctionnon-kinase phorbol ester receptor activity

UNC13B UNC13C

4.88e-0521402GO:0001566
GeneOntologyMolecularFunctioncalcium ion binding

UNC13B NECAB2 PCDHGA7 SPTA1 ITSN1 PPP2R3B CASQ1 DYSF TENM2 RYR1 PPP2R3A CELSR1 GUCA1A USP32 ANXA10 UNC13C

7.35e-0574914016GO:0005509
GeneOntologyMolecularFunctionphosphatidylethanolamine binding

MAP1LC3A GABARAPL1 MAP1LC3C

3.01e-04191403GO:0008429
GeneOntologyMolecularFunctionthreonine-type peptidase activity

PSMB5 GGT2P GGT3P

3.52e-04201403GO:0070003
GeneOntologyMolecularFunctioncalcium- and calmodulin-responsive adenylate cyclase activity

ADCY3 ADCY8

4.81e-0451402GO:0008294
GeneOntologyMolecularFunctionpeptidyltransferase activity

GGT2P GGT3P

7.19e-0461402GO:0000048
GeneOntologyMolecularFunctionleukotriene-C(4) hydrolase

GGT2P GGT3P

7.19e-0461402GO:0002951
GeneOntologyMolecularFunctionhistone H3K9me2/H3K9me3 demethylase activity

KDM4E KDM4B

7.19e-0461402GO:0140684
GeneOntologyMolecularFunctionprotein serine kinase activity

PAK4 WNK1 MAP3K6 CIITA MARK4 CHEK2 MASTL PAK2 PRKCA

1.07e-033631409GO:0106310
GeneOntologyMolecularFunctionprotein kinase activity

PAK4 WNK1 MAP3K6 TXK IGF1R CIITA MARK4 CHEK2 MASTL PAK2 PRKCA ROS1

1.08e-0360014012GO:0004672
GeneOntologyCellularComponentcone photoreceptor outer segment

IFT140 GUCA1A PRKCA

4.57e-05111393GO:0120199
GeneOntologyCellularComponentcalyx of Held

UNC13B ITSN1 PRKCA UNC13C

9.35e-05361394GO:0044305
GeneOntologyCellularComponentPML body

EIF3E TENM2 UBN1 CIITA ZNF451 CHEK2

1.90e-041251396GO:0016605
GeneOntologyCellularComponentterminal cisterna

CASQ1 RYR1

2.61e-0441392GO:0014802
GeneOntologyCellularComponentcollagen type XI trimer

COL5A1 COL11A1

4.33e-0451392GO:0005592
GeneOntologyCellularComponentaxonemal dynein complex

DNAH1 CFAP70 DNAH5

5.94e-04251393GO:0005858
GeneOntologyCellularComponentcytoplasmic region

UNC13B IFT140 LRRC43 DNAH1 GABARAPL1 UNC13C CFAP70 DNAH5 BRWD1

6.94e-043601399GO:0099568
DomainAtg8

MAP1LC3A GABARAPL1 MAP1LC3C

2.25e-0581403PF02991
DomainAtg8-like

MAP1LC3A GABARAPL1 MAP1LC3C

2.25e-0581403IPR004241
Domain-

NECAB2 SPTA1 ITSN1 PPP2R3B RYR1 PPP2R3A GUCA1A USP32 PLCE1

1.58e-0426114091.10.238.10
DomainRhs_assc_core

TENM2 TENM4

1.67e-0431402IPR022385
DomainUnc-13

UNC13B UNC13C

1.67e-0431402IPR027080
DomainTPR_REGION

IFT140 ZFC3H1 VPS13A AIPL1 CFAP70 EMC2 TTC38

2.48e-041651407PS50293
DomainTPR

IFT140 ZFC3H1 VPS13A AIPL1 CFAP70 EMC2 TTC38

2.48e-041651407PS50005
DomainEF-hand-dom_pair

NECAB2 SPTA1 ITSN1 PPP2R3B RYR1 PPP2R3A GUCA1A USP32 PLCE1

3.19e-042871409IPR011992
DomainTox-GHH_dom

TENM2 TENM4

3.31e-0441402IPR028916
DomainTox-GHH

TENM2 TENM4

3.31e-0441402PF15636
DomainTen_N

TENM2 TENM4

3.31e-0441402IPR009471
DomainTen_N

TENM2 TENM4

3.31e-0441402PF06484
DomainTENEURIN_N

TENM2 TENM4

3.31e-0441402PS51361
DomainEF_hand_dom

NECAB2 SPTA1 ITSN1 PPP2R3B RYR1 PPP2R3A GUCA1A USP32

3.68e-042321408IPR002048
DomainTPR-like_helical_dom

SART3 IFT140 ZFC3H1 VPS41 AIPL1 CFAP70 EMC2 TTC38

3.78e-042331408IPR011990
DomainPRY

TRIM21 TRIM62 BTN1A1 BTN2A3P

4.56e-04481404SM00589
DomainPRY

TRIM21 TRIM62 BTN1A1 BTN2A3P

4.56e-04481404IPR006574
DomainC2

UNC13B ITSN1 DYSF PRKCA UNC13C PLCE1

4.62e-041311406PF00168
DomainSPRY

TRIM21 RYR1 TRIM62 BTN1A1 BTN2A3P

4.97e-04871405SM00449
DomainMunc13_dom-2

UNC13B UNC13C

5.50e-0451402IPR014772
DomainMHD2

UNC13B UNC13C

5.50e-0451402PS51259
DomainMunc13_subgr_dom-2

UNC13B UNC13C

5.50e-0451402IPR019558
DomainYD

TENM2 TENM4

5.50e-0451402IPR006530
DomainMembr_traf_MHD

UNC13B UNC13C

5.50e-0451402PF10540
DomainDUF1041

UNC13B UNC13C

5.50e-0451402SM01145
DomainC2

UNC13B ITSN1 DYSF PRKCA UNC13C PLCE1

5.86e-041371406SM00239
DomainPROTEIN_KINASE_ATP

PAK4 WNK1 MAP3K6 TXK IGF1R MARK4 CHEK2 MASTL PAK2 PRKCA ROS1

6.92e-0445914011PS00107
DomainC2

UNC13B ITSN1 DYSF PRKCA UNC13C PLCE1

7.08e-041421406PS50004
DomainSPRY

TRIM21 RYR1 TRIM62 BTN1A1 BTN2A3P

7.08e-04941405PF00622
DomainSPRY_dom

TRIM21 RYR1 TRIM62 BTN1A1 BTN2A3P

7.08e-04941405IPR003877
DomainB30.2/SPRY

TRIM21 RYR1 TRIM62 BTN1A1 BTN2A3P

7.43e-04951405IPR001870
DomainB302_SPRY

TRIM21 RYR1 TRIM62 BTN1A1 BTN2A3P

7.43e-04951405PS50188
DomainMA3

CWC22 EIF4G1

8.20e-0461402SM00544
DomainMA3

CWC22 EIF4G1

8.20e-0461402PF02847
DomainPAK_BD

PAK4 PAK2

8.20e-0461402IPR033923
DomainInitiation_fac_eIF4g_MI

CWC22 EIF4G1

8.20e-0461402IPR003891
DomainMI

CWC22 EIF4G1

8.20e-0461402PS51366
Domain-

UNC13B ITSN1 DYSF PRKCA UNC13C PLCE1

8.78e-0414814062.60.40.150
DomainTPR-contain_dom

IFT140 ZFC3H1 VPS13A AIPL1 CFAP70 EMC2

9.42e-041501406IPR013026
DomainMunc13_1

UNC13B UNC13C

1.14e-0371402IPR014770
DomainWASP_C

PAK4 PAK2

1.14e-0371402IPR011026
DomainMHD1

UNC13B UNC13C

1.14e-0371402PS51258
DomainPeptidase_M13_C

PHEX ECE2

1.14e-0371402IPR018497
DomainPeptidase_M13

PHEX ECE2

1.14e-0371402IPR000718
DomainPeptidase_M13_N

PHEX ECE2

1.14e-0371402PF05649
DomainPeptidase_M13_N

PHEX ECE2

1.14e-0371402IPR008753
DomainDUF1041

UNC13B UNC13C

1.14e-0371402PF06292
DomainCAPS_dom

UNC13B UNC13C

1.14e-0371402IPR010439
DomainPeptidase_M13

PHEX ECE2

1.14e-0371402PF01431
DomainProt_kinase_dom

PAK4 WNK1 MAP3K6 TXK IGF1R MARK4 CHEK2 MASTL PAK2 PRKCA ROS1

1.16e-0348914011IPR000719
DomainPROTEIN_KINASE_DOM

PAK4 WNK1 MAP3K6 TXK IGF1R MARK4 CHEK2 MASTL PAK2 PRKCA ROS1

1.23e-0349314011PS50011
DomainConA-like_dom

COL5A1 COL11A1 TRIM21 RYR1 CELSR1 TRIM62 BTN1A1

1.33e-032191407IPR013320
DomainC2_dom

UNC13B ITSN1 DYSF PRKCA UNC13C PLCE1

1.49e-031641406IPR000008
DomainAC_N

ADCY3 ADCY8

1.52e-0381402IPR032628
DomainAdcy

ADCY3 ADCY8

1.52e-0381402IPR030672
DomainAC_N

ADCY3 ADCY8

1.52e-0381402PF16214
DomainEF_HAND_2

NECAB2 SPTA1 ITSN1 PPP2R3B PPP2R3A GUCA1A USP32

1.81e-032311407PS50222
DomainButyrophylin

TRIM21 TRIM62 BTN1A1 BTN2A3P

1.89e-03701404IPR003879
DomainEF_Hand_1_Ca_BS

NECAB2 ITSN1 PPP2R3B PPP2R3A GUCA1A USP32

2.07e-031751406IPR018247
DomainMIF4G

CWC22 EIF4G1

2.41e-03101402SM00543
DomainJmjN

KDM4E KDM4B

2.41e-03101402SM00545
DomainMIF4G

CWC22 EIF4G1

2.41e-03101402PF02854
DomainJmjN

KDM4E KDM4B

2.41e-03101402PF02375
DomainHAT

SART3 ZFC3H1

2.41e-03101402SM00386
DomainMIF4G-like_typ-3

CWC22 EIF4G1

2.41e-03101402IPR003890
DomainJMJN

KDM4E KDM4B

2.41e-03101402PS51183
DomainHAT

SART3 ZFC3H1

2.41e-03101402IPR003107
DomainJmjN

KDM4E KDM4B

2.41e-03101402IPR003349
DomainKinase-like_dom

PAK4 WNK1 MAP3K6 TXK IGF1R MARK4 CHEK2 MASTL PAK2 PRKCA ROS1

2.59e-0354214011IPR011009
DomainNC1_FIB

COL5A1 COL11A1

2.94e-03111402PS51461
DomainFib_collagen_C

COL5A1 COL11A1

2.94e-03111402PD002078
DomainFib_collagen_C

COL5A1 COL11A1

2.94e-03111402IPR000885
DomainCOLFI

COL5A1 COL11A1

2.94e-03111402PF01410
DomainTyr_kinase_rcpt_2_CS

IGF1R ROS1

2.94e-03111402IPR002011
DomainCOLFI

COL5A1 COL11A1

2.94e-03111402SM00038
Domain-

TENM2 TENM4 ROS1

3.09e-033914032.120.10.30
DomainLaminin_G_2

COL5A1 COL11A1 CELSR1

3.33e-03401403PF02210
Domain-

PAK4 PAK2

3.51e-031214023.90.810.10
DomainAPOBEC_N

APOBEC3B APOBEC3C

3.51e-03121402PF08210
DomainRECEPTOR_TYR_KIN_II

IGF1R ROS1

3.51e-03121402PS00239
DomainPeptidase_M1

ANPEP AOPEP

3.51e-03121402IPR001930
DomainAPOBEC_N

APOBEC3B APOBEC3C

3.51e-03121402IPR013158
DomainPRY

TRIM21 TRIM62 BTN1A1

3.82e-03421403PF13765
DomainPeptidase_M1_N

ANPEP AOPEP

4.12e-03131402IPR014782
DomainPeptidase_M1

ANPEP AOPEP

4.12e-03131402PF01433
DomainNHL

TENM2 TENM4

4.12e-03131402PS51125
DomainLamG

COL5A1 COL11A1 CELSR1

4.36e-03441403SM00282
DomainEF_HAND_1

NECAB2 ITSN1 PPP2R3B PPP2R3A GUCA1A USP32

4.41e-032041406PS00018
DomainDynein_heavy_chain_D4_dom

DNAH1 DNAH5

4.79e-03141402IPR024317
DomainDynein_HC_stalk

DNAH1 DNAH5

4.79e-03141402IPR024743
DomainDynein_heavy_dom-2

DNAH1 DNAH5

4.79e-03141402IPR013602
DomainDHC_N2

DNAH1 DNAH5

4.79e-03141402PF08393
DomainATPase_dyneun-rel_AAA

DNAH1 DNAH5

4.79e-03141402IPR011704
DomainMT

DNAH1 DNAH5

4.79e-03141402PF12777
DomainAAA_8

DNAH1 DNAH5

4.79e-03141402PF12780
DomainAPOBEC/CMP_deaminase_Zn-bd

APOBEC3B APOBEC3C

4.79e-03141402IPR016192
DomainAAA_5

DNAH1 DNAH5

4.79e-03141402PF07728
Domain6-blade_b-propeller_TolB-like

TENM2 TENM4 ROS1

4.94e-03461403IPR011042
DomainDHC_fam

DNAH1 DNAH5

5.49e-03151402IPR026983
Domain-

CWC22 EIF4G1

5.49e-031514021.25.40.180
Pubmed

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.

MAP1LC3A TRIM21 NLRP3 GABARAPL1 MAP1LC3C

1.13e-0819141526347139
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

UNC13B SEMA3F EPPK1 CEP192 WRAP53 DYSF WNK1 RYR1 MYORG TIAM2 CELSR1 IGF1R UBN1 KLHL21 SUMF1 MARK4 EIF4G1 TTC38 SDHA

1.21e-0711051411935748872
Pubmed

An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteins.

MAP1LC3A GABARAPL1 MAP1LC3C

2.26e-067141334929165
Pubmed

Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs.

COL5A1 WNK1 SLC6A12 SYCP2 TRPM8 TRPM1

3.48e-06100141626073538
Pubmed

Autophagy receptor NDP52 regulates pathogen-containing autophagosome maturation.

MAP1LC3A GABARAPL1 MAP1LC3C

3.60e-068141325771791
Pubmed

TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1.

MAP1LC3A GABARAPL1 MAP1LC3C

3.60e-068141331685529
Pubmed

Mass spectrometry proteomics reveals a function for mammalian CALCOCO1 in MTOR-regulated selective autophagy.

MAP1LC3A GABARAPL1 MAP1LC3C

3.60e-068141331971854
Pubmed

DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription.

MAP1LC3A GABARAPL1 MAP1LC3C

3.60e-068141322470510
Pubmed

Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins.

MAP1LC3A GABARAPL1 MAP1LC3C

5.38e-069141329867141
Pubmed

The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.

MAP1LC3A GABARAPL1 MAP1LC3C

5.38e-069141329251248
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

UNC13B ZBTB43 CEP192 CSMD3 TENM2 ADCY3 TENM4 ZNF451 MARK4 PLCE1

6.83e-064071411012693553
Pubmed

A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.

MAP1LC3A GABARAPL1 MAP1LC3C

7.67e-0610141319250911
Pubmed

The IAP family member BRUCE regulates autophagosome-lysosome fusion.

MAP1LC3A GABARAPL1 MAP1LC3C

7.67e-0610141329426817
Pubmed

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα.

MAP1LC3A GABARAPL1 MAP1LC3C

7.67e-0610141330217973
Pubmed

ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8.

MAP1LC3A GABARAPL1 MAP1LC3C

7.67e-0610141328287329
Pubmed

ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs.

MAP1LC3A GABARAPL1 MAP1LC3C

1.05e-0511141323043107
Pubmed

Methods for Studying Interactions Between Atg8/LC3/GABARAP and LIR-Containing Proteins.

MAP1LC3A GABARAPL1 MAP1LC3C

1.05e-0511141328253953
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

SEMA3F COL11A1 EPPK1 PSMB5 EIF3E TRIM21 TIAM2 KLHL21 EIF4G1 ROS1 OSTF1 SDHA EXOC4

1.31e-057541411335906200
Pubmed

Clinical significance of the correlation between PLCE 1 and PRKCA in esophageal inflammation and esophageal carcinoma.

PRKCA PLCE1

1.63e-052141228402280
Pubmed

The Effect of PKCα on the Light Response of Rod Bipolar Cells in the Mouse Retina.

PRKCA TRPM1

1.63e-052141226230760
Pubmed

Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma.

APOBEC3B APOBEC3C

1.63e-052141225650088
Pubmed

Strenuous exercise triggers a life-threatening response in mice susceptible to malignant hyperthermia.

CASQ1 RYR1

1.63e-052141228465322
Pubmed

Regulated production and anti-HIV type 1 activities of cytidine deaminases APOBEC3B, 3F, and 3G.

APOBEC3B APOBEC3C

1.63e-052141216060832
Pubmed

TRIM62 knockout protects against cerebral ischemic injury in mice by suppressing NLRP3-regulated neuroinflammation.

NLRP3 TRIM62

1.63e-052141232703402
Pubmed

Structure of a full-length cDNA clone for the pro-alpha1(V/XI) collagen chain of red seabream.

COL5A1 COL11A1

1.63e-052141211342118
Pubmed

Munc13-independent vesicle priming at mouse photoreceptor ribbon synapses.

UNC13B UNC13C

1.63e-052141222674279
Pubmed

APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication.

APOBEC3B APOBEC3C

1.63e-052141215466872
Pubmed

Oxygen Consumption and Basal Metabolic Rate as Markers of Susceptibility to Malignant Hyperthermia and Heat Stroke.

CASQ1 RYR1

1.63e-052141236010545
Pubmed

[Expression and significance of IGF-IR and PKC in laryngeal squamous cell carcinoma].

IGF1R PRKCA

1.63e-052141220422977
Pubmed

WNK1 is an assembly factor for the human ER membrane protein complex.

WNK1 EMC2

1.63e-052141233964204
Pubmed

Integrative genomic analysis reveals functional diversification of APOBEC gene family in breast cancer.

APOBEC3B APOBEC3C

1.63e-052141226682542
Pubmed

APOBEC3-induced mutation of the hepatitis virus B DNA genome occurs during its viral RNA reverse transcription into (-)-DNA.

APOBEC3B APOBEC3C

1.63e-052141234181944
Pubmed

Identification of PKCα-dependent phosphoproteins in mouse retina.

PRKCA TRPM1

1.63e-052141231255707
Pubmed

Expression of truncated eukaryotic initiation factor 3e (eIF3e) resulting from integration of mouse mammary tumor virus (MMTV) causes a shift from cap-dependent to cap-independent translation.

EIF3E EIF4G1

1.63e-052141221737453
Pubmed

The IGF-I receptor can alter the matrix metalloproteinase repertoire of tumor cells through transcriptional regulation of PKC-{alpha}.

IGF1R PRKCA

1.63e-052141219855090
Pubmed

Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.

ANO4 APOBEC3B ADCY8 APOBEC3C

1.91e-0539141424709693
Pubmed

Docking motif-guided mapping of the interactome of protein phosphatase-1.

ZCCHC9 CNST CEP192 WNK1 UBN1

1.92e-0580141519389623
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

PAK4 EIF3E CEP192 CUL7 BCAR1 MAP3K6 IGF1R GABARAPL1 ANAPC1 EIF4G1 CHEK2 PRKCA OSTF1 PIP4K2C

2.14e-059101411436736316
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

ANPEP CD109 TRIM21 CUL7 RYR1 BTN1A1 DNAH5

2.85e-05214141722199357
Pubmed

CCT2 is an aggrephagy receptor for clearance of solid protein aggregates.

MAP1LC3A GABARAPL1 MAP1LC3C

2.86e-0515141335366418
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

DHX40 ITSN1 CEP192 CUL7 BCAR1 WNK1 UBN1 ANAPC1 ZNF451 PIP4K2C EXOC4

2.98e-055881411138580884
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

MAGI1 COL5A1 EOGT CEP192 BCAR1 ADCY3 DNAH1 PPP2R3A AP1S1 IGF1R THEM4 AOPEP VPS41 OSTF1 OLFM2 KDM4B DOP1A EXOC4

3.49e-0514891411828611215
Pubmed

The cleavage of host cell proteins by HIV-1 protease.

SPTA1 MAP1LC3A MAP1LC3C

4.25e-051714138997639
Pubmed

Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence.

NLRP3 IGF1R

4.88e-053141226876170
Pubmed

MARK4 (Microtubule Affinity-Regulating Kinase 4)-Dependent Inflammasome Activation Promotes Atherosclerosis-Brief Report.

NLRP3 MARK4

4.88e-053141231167564
Pubmed

Protein phosphatase 2A interacts with the Src kinase substrate p130(CAS).

PPP2R3B BCAR1

4.88e-053141211593413
Pubmed

A new PKCα/β/TBX3/E-cadherin pathway is involved in PLCε-regulated invasion and migration in human bladder cancer cells.

PRKCA PLCE1

4.88e-053141224316392
Pubmed

Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death.

CASQ1 RYR1

4.88e-053141224143248
Pubmed

Overexpression of insulin-like growth factor 1 receptor and frequent mutational inactivation of SDHA in wild-type SDHB-negative gastrointestinal stromal tumors.

IGF1R SDHA

4.88e-053141223109135
Pubmed

Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia.

ADCY3 ADCY8

4.88e-053141217586501
Pubmed

LC3C Contributes to Vpu-Mediated Antagonism of BST2/Tetherin Restriction on HIV-1 Release through a Non-canonical Autophagy Pathway.

MAP1LC3A MAP1LC3C

4.88e-053141227880899
Pubmed

A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line.

ADCY3 ADCY8

4.88e-05314128476432
Pubmed

Alteration of autophagosomal proteins in the brain of multiple system atrophy.

MAP1LC3A GABARAPL1

4.88e-053141222959883
Pubmed

Distinct regions of triadin are required for targeting and retention at the junctional domain of the sarcoplasmic reticulum.

CASQ1 RYR1

4.88e-053141224325401
Pubmed

MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism.

NLRP3 MARK4

4.88e-053141228656979
Pubmed

Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.

EIF3E EIF4G1

4.88e-053141216766523
Pubmed

Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B.

MAP1LC3A MAP1LC3C

4.88e-053141212740394
Pubmed

Tripartite-motif protein 21 knockdown extenuates LPS-triggered neurotoxicity by inhibiting microglial M1 polarization via suppressing NF-κB-mediated NLRP3 inflammasome activation.

TRIM21 NLRP3

4.88e-053141233992596
Pubmed

Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.

UNC13B UNC13C

4.88e-053141233105896
Pubmed

cDNA sequence and expression of the mouse alpha1(V) collagen gene (Col5a1).

COL5A1 COL11A1

4.88e-05314129582436
Pubmed

Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.

EIF4G1 PRKCA

4.88e-053141221576361
Pubmed

Novel Insights into the Cellular Localization and Regulation of the Autophagosomal Proteins LC3A, LC3B and LC3C.

MAP1LC3A MAP1LC3C

4.88e-053141233081014
Pubmed

p21-Activated Kinases 1, 2 and 4 in Endometrial Cancers: Effects on Clinical Outcomes and Cell Proliferation.

PAK4 PAK2

4.88e-053141226218748
Pubmed

The Association of Variants within Types V and XI Collagen Genes with Knee Joint Laxity Measurements.

COL5A1 COL11A1

4.88e-053141236553626
Pubmed

Evaluation of APOBEC3 expression as prognostic marker in squamous cell carcinoma of the penis.

APOBEC3B APOBEC3C

4.88e-053141235902635
Pubmed

Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein.

PPP2R3B PPP2R3A

4.88e-05314129927208
Pubmed

Genetic variants and susceptibility to neurological complications following West Nile virus infection.

ANPEP RFC1

4.88e-053141221881118
Pubmed

Hypomorphic mutation in the large subunit of replication protein A affects mutagenesis by human APOBEC cytidine deaminases in yeast.

APOBEC3B APOBEC3C

4.88e-053141239150943
Pubmed

Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF.

PAK4 PAK2

4.88e-053141217555715
Pubmed

The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.

UNC13B UNC13C

4.88e-053141223658173
Pubmed

Dysferlin interacts with calsequestrin-1, myomesin-2 and dynein in human skeletal muscle.

CASQ1 DYSF

4.88e-053141223792176
Pubmed

Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1.

APOBEC3B APOBEC3C

4.88e-053141210469298
Pubmed

Association Between COL5a1, COL11a1, and COL11a2 Gene Variations and Rotator Cuff Tendinopathy in Young Athletes.

COL5A1 COL11A1

4.88e-053141234009784
Pubmed

Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors.

APOBEC3B APOBEC3C

4.88e-053141227643540
Pubmed

Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk.

EIF4G1 PAK2

4.88e-053141215234964
Pubmed

Role and mechanism of action of the APOBEC3 family of antiretroviral resistance factors.

APOBEC3B APOBEC3C

4.88e-053141216414984
Pubmed

Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans.

ANPEP IGF1R

4.88e-053141219330903
Pubmed

The Insulin Receptor and Insulin like Growth Factor Receptor 5' UTRs Support Translation Initiation Independently of EIF4G1.

IGF1R EIF4G1

4.88e-053141237724583
Pubmed

Heat shock proteins stimulate APOBEC-3-mediated cytidine deamination in the hepatitis B virus.

APOBEC3B APOBEC3C

4.88e-053141228637869
Pubmed

A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L.

MAP1LC3A GABARAPL1

4.88e-053141214530254
Pubmed

Different gamma-glutamyl transpeptidase mRNAs are expressed in human liver and kidney.

GGT2P GGT3P

4.88e-05314122573352
Pubmed

Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity.

UNC13B UNC13C

4.88e-053141222966208
Pubmed

Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse.

UNC13B UNC13C

4.88e-053141215988013
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

EPPK1 ITSN1 TMEM151B BCAR1 UBN1 EIF4G1 UGCG DNAH5

6.68e-05332141837433992
Pubmed

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.

MAP1LC3A GABARAPL1 MAP1LC3C

7.07e-0520141325127057
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

IFT140 ZFC3H1 ADCY3 ZNF451 ECE2

7.11e-0510514159628581
Pubmed

Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.

ITSN1 MAP1LC3A GABARAPL1 MAP1LC3C CHEK2

8.87e-05110141537219487
Pubmed

Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B" subunits of protein phosphatase 2A.

PPP2R3B PPP2R3A

9.74e-054141218715506
Pubmed

Collagen XI chain misassembly in cartilage of the chondrodysplasia (cho) mouse.

COL5A1 COL11A1

9.74e-054141217683922
Pubmed

Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues.

TENM2 TENM4

9.74e-054141210225957
Pubmed

Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex.

PAK2 EXOC4

9.74e-054141226350970
Pubmed

Domain- and sequence-specific phosphorylation of vimentin induces disassembly of the filament structure.

PAK2 PRKCA

9.74e-05414122500966
Pubmed

The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets.

MAP1LC3A MAP1LC3C

9.74e-054141237443287
Pubmed

Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia.

DNAH1 DNAH5

9.74e-054141218492703
Pubmed

Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function.

DNAH1 CFAP70

9.74e-054141237934199
Pubmed

Pak to the future.

PAK4 PAK2

9.74e-054141210461188
Pubmed

HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates.

MAP1LC3A MAP1LC3C

9.74e-054141215187094
Pubmed

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia.

PAK4 PAK2

9.74e-05414129822598
Pubmed

Species-specific restriction of apobec3-mediated hypermutation.

APOBEC3B APOBEC3C

9.74e-054141218032489
Pubmed

Human eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome.

EIF3E EIF4G1

9.74e-054141224092755
Cytoband5p15

SRD5A1 SDHA

1.95e-04714125p15
CytobandEnsembl 112 genes in cytogenetic band chr8q23

EIF3E CSMD3 EMC2

5.30e-04511413chr8q23
CytobandEnsembl 112 genes in cytogenetic band chr12q23

ANO4 SART3 ALDH1L2 ACTR6

1.22e-031501414chr12q23
Cytoband9q31

FRRS1L UGCG

1.24e-031714129q31
Cytoband4p12

ATP10D TXK

1.72e-032014124p12
Cytoband6p21.1

TMEM151B CUL7 GUCA1A

1.96e-038014136p21.1
Cytoband3p14.1

MAGI1 EOGT

2.47e-032414123p14.1
Cytoband1q21

SPTA1 CASQ1 THEM4

2.83e-039114131q21
CytobandEnsembl 112 genes in cytogenetic band chr4p12

ATP10D TXK

2.90e-03261412chr4p12
CytobandEnsembl 112 genes in cytogenetic band chr22q13

APOBEC3B TUBGCP6 CELSR1 APOBEC3C TTC38

3.63e-033301415chr22q13
GeneFamilyUNC13 homologs

UNC13B UNC13C

1.99e-0441052836
GeneFamilyEF-hand domain containing

NECAB2 SPTA1 ITSN1 PPP2R3B PPP2R3A GUCA1A USP32

2.90e-042191057863
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

ZCCHC9 CNST CEP192 WNK1 RYR1 UBN1

6.57e-041811056694
GeneFamilyAutophagy related

MAP1LC3A GABARAPL1 MAP1LC3C

9.15e-043310531022
GeneFamilyAdenylate cyclases|Deafness associated genes

ADCY3 ADCY8

1.46e-0310105253
GeneFamilyApolipoprotein B mRNA editing enzyme catalytic subunits

APOBEC3B APOBEC3C

2.12e-03121052406
GeneFamilyCollagens

COL5A1 COL11A1 COL6A5

2.41e-03461053490
GeneFamilyCD molecules|Gamma-glutamyltransferases

GGT2P GGT3P

2.50e-03131052564
GeneFamilyWD repeat domain containing|Protein phosphatase 2 regulatory subunits

PPP2R3B PPP2R3A

3.34e-03151052696
GeneFamilyButyrophilins|V-set domain containing|C2-set domain containing

BTN1A1 BTN2A3P

3.34e-03151052458
GeneFamilyDyneins, axonemal

DNAH1 DNAH5

4.29e-03171052536
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL11A1 SPTA1 CSMD3 DNAH1 SYCP2 TENM4 UNC13C ROS1 DNAH5 PLCE1

3.98e-10184141102cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL11A1 SPTA1 CSMD3 DNAH1 SYCP2 TENM4 UNC13C ROS1 DNAH5 PLCE1

3.98e-1018414110ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL11A1 SPTA1 CSMD3 DNAH1 SYCP2 TENM4 UNC13C ROS1 DNAH5 PLCE1

3.98e-10184141102b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NPR3 COL11A1 COL6A5 TENM2 TIAM2 ZFYVE28 SLC7A3

7.04e-0715714171f21d78a467fe22c5ab75d0917b840c1ac93f32c
ToppCelldroplet-Marrow-BM-30m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B TSPAN15 SEMA3F DPYS FAAH SLC7A3 ALDH1L2

2.03e-0618414171e54fd372c6e6a298f427b807c14cc49aaaffe80
ToppCelldroplet-Lung-nan-3m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANPEP CASQ1 RYR1 DNAH1 CIITA DOP1A

1.55e-051671416f33cef917fa733adf6d5a9a9e989a4d9fd462a8f
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTA1 CSMD3 DNAH1 TRPM8 UNC13C DNAH5

1.66e-05169141612bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

COL5A1 COL6A5 CEP192 TENM4 CIITA KDM4B

1.71e-051701416ba4ba66b624089ed50a9083176386c7941b4c7a3
ToppCell10x5'v1-week_12-13-Mesenchymal_osteo-stroma-osteoblast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

COL5A1 PCDHGA7 MYORG PHEX DUSP29 ALDH1L2

2.52e-051821416ba066ff9029cc052b76e2330ec168cb2e9b7e498
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANO4 TSPAN15 SRD5A1 CUL7 GABARAPL1 PAK2

2.84e-05186141639e475a3c167b33daa63b0c1bfa32451c5f46635
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

UNC13B MAGI1 GSAP CELSR1 ROS1 DNAH5

2.84e-0518614162ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANO4 TSPAN15 SRD5A1 CUL7 GABARAPL1 PAK2

2.84e-05186141602418c50fdcca549bf73dedf6199ab4a27862a9b
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

UNC13B MAGI1 GSAP ADCY8 GGT2P ROS1

3.20e-0519014168aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

UNC13B MAGI1 COL11A1 ADCY8 GGT2P ROS1

3.30e-05191141634cc997e4e5c727495f321e6807a84aa124da486
ToppCellLeuk-UTI-Lymphocyte-T_NK-CD4_Naive|Leuk-UTI / Disease, Lineage and Cell Type

EPPK1 EIF3E TXK THEM4 PRKCA OLFM2

3.39e-051921416ecdcb210a448495fc141ddc946cca1fbd821ad83
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

UNC13B MAGI1 COL11A1 ADCY8 GGT2P ROS1

3.39e-051921416fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCellHealthy/Control-CD4+_T_naive|Healthy/Control / Disease group and Cell class

EPPK1 EIF3E TXK IGF1R THEM4 PRKCA

3.49e-051931416f5face746df3517c86d72e31ba8f1b78c4c6b481
ToppCellHealthy/Control-CD4+_T_naive|World / Disease group and Cell class

EPPK1 EIF3E TXK IGF1R THEM4 PRKCA

3.49e-0519314166218e6cbe44d92bb98d42ef2f5e18ab7a683b100
ToppCellHealthy_donor-CD4+_T_naive|World / disease group, cell group and cell class (v2)

EPPK1 EIF3E TXK IGF1R THEM4 PRKCA

3.60e-051941416bcaaa6b6ce5b3552f11311d8ee91c35b8ec065f8
ToppCellHealthy_donor-CD4+_T_naive|Healthy_donor / disease group, cell group and cell class (v2)

EPPK1 EIF3E TXK IGF1R THEM4 PRKCA

3.60e-051941416a8a0368a4e0eb5654fdffc8a779b08ad402aa2eb
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GSDMC CELSR1 TENM4 UGCG DNAH5 PLCE1

3.81e-051961416b07db4a53ab9be9aad6fae5e45f9547db829d096
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GSDMC CELSR1 TENM4 UGCG DNAH5 PLCE1

3.81e-051961416c366f980cc04abfe1c0c14746c11810c812a42c0
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

UNC13B MAGI1 IGF1R AOPEP PRKCA EXOC4

4.03e-0519814161996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellSepsis-Leuk-UTI-Lymphocyte-T/NK-CD4+_T_naive|Leuk-UTI / Disease, condition lineage and cell class

EPPK1 EIF3E TXK THEM4 PRKCA OLFM2

4.26e-052001416a542c302ac266ed0ead355b5011f0aff39320ed7
ToppCellCOVID-19_Mild-Neu_1|World / 5 Neutrophil clusters in COVID-19 patients

HLF BCAR1 DUSP29 UNC13C DNAH5

4.88e-051251415e58c208b4355252ceabe04a468dd19a1f436182c
DrugMethapyrilene hydrochloride [135-23-9]; Down 200; 13.4uM; PC3; HT_HG-U133A

HLF WNK1 PPP2R3A AP1S1 GABARAPL1 MARK4 EIF4G1 UGCG APOBEC3C KDM4B

3.25e-07191141106644_DN
DrugIvermectin [70288-86-7]; Down 200; 4.6uM; PC3; HT_HG-U133A

COL5A1 EPPK1 ZBTB43 WRAP53 ATP10D PPP2R3A AP1S1 CHEK2 BRWD1

3.80e-0619614192051_DN
DrugPropoxycaine hydrochloride [550-83-4]; Up 200; 12uM; PC3; HT_HG-U133A

IFT140 NPR3 AP1S1 GABARAPL1 TRIM62 VPS13A TTC38 KDM4B BRWD1

3.80e-0619614197155_UP
DrugPHA-00745360 [351320-33-7]; Up 200; 1uM; MCF7; HT_HG-U133A

IFT140 NPR3 ANPEP CHRNB2 SLC2A5 AP1S1 GABARAPL1 AOPEP KDM4B

3.96e-0619714193910_UP
DrugPrimaquine diphosphate [63-45-6]; Down 200; 8.8uM; MCF7; HT_HG-U133A

ZBTB43 WRAP53 WNK1 PPP2R3A IGF1R EIF4G1 UGCG BRWD1

2.31e-0518814184845_DN
DrugFlupentixol dihydrochloride cis-(Z) [2413-38-9]; Down 200; 7.8uM; HL60; HT_HG-U133A

ZBTB43 WNK1 IGF1R UBN1 UGCG KDM4B DOP1A BRWD1

2.40e-0518914181288_DN
Drugalpha-Santonin [481-06-1]; Up 200; 16.2uM; PC3; HT_HG-U133A

COL5A1 HLF CUL7 TXK PHEX VPS41 TRPM1 DOP1A

2.90e-0519414184531_UP
DrugBumetanide [28395-03-1]; Down 200; 11uM; PC3; HT_HG-U133A

COL5A1 NPR3 EPPK1 ZBTB43 CUL7 MAP3K6 AP1S1 MARK4

3.00e-0519514185117_DN
DrugNeomycin sulfate [1405-10-3]; Down 200; 4.2uM; PC3; HT_HG-U133A

ZBTB43 TRIM21 CUL7 ATP10D AP1S1 TRIM62 VPS13A BRWD1

3.12e-0519614182066_DN
Drug(-)-Eseroline fumarate salt [104015-29-4]; Up 200; 12uM; PC3; HT_HG-U133A

SEMA3F NPR3 CUL7 PHEX GABARAPL1 RNF146 MARK4 OSTF1

3.23e-0519714187267_UP
DrugPancuronium bromide [15500-66-0]; Down 200; 5.4uM; HL60; HT_HG-U133A

EOGT TCN1 WNK1 NLRP3 SYCP2 MARK4 UGCG PRKCA

3.23e-0519714182909_DN
DrugNalidixic acid sodium salt hydrate; Down 200; 14.6uM; MCF7; HT_HG-U133A

SEMA3F IFT140 CUL7 FAAH PHEX SYCP2 MARK4 TTC38

3.35e-0519814182297_DN
DrugBaclofen (R,S) [1134-47-0]; Up 200; 18.8uM; MCF7; HT_HG-U133A

COL5A1 NPR3 GSAP WNK1 PHEX AP1S1 MARK4 APOBEC3C

3.35e-0519814185414_UP
DrugBenzathine benzylpenicillin [5928-84-7]; Down 200; 4.2uM; HL60; HT_HG-U133A

WRAP53 DYSF WNK1 ADCY3 MARK4 VPS13A APOBEC3C TTC38

3.60e-0520014182939_DN
Diseaseage at menarche

COL11A1 HLF TENM2 ADCY3 ADCY8 IGF1R EIF4G1 UNC13C OLFM2 KDM4B ECE2 BRWD1

2.99e-0559414112EFO_0004703
Diseaseheight-adjusted body mass index

ADCY3 ADCY8

6.78e-0531412EFO_0005851
DiseaseTourette syndrome

CSMD3 TENM2 PHEX TENM4

9.70e-05501414EFO_0004895
DiseaseIGF-1 measurement

IFT140 HLF EIF3E PPP2R3A AOPEP RNF146 PRKCA AKAP10 PIP4K2C KDM4B

1.25e-0448814110EFO_0004627
DiseaseDrug habituation

ANO4 CSMD3 TENM2 FAAH TIAM2

2.34e-041151415C0013170
DiseaseDrug abuse

ANO4 CSMD3 TENM2 FAAH TIAM2

2.34e-041151415C0013146
DiseasePrescription Drug Abuse

ANO4 CSMD3 TENM2 FAAH TIAM2

2.34e-041151415C4316881
DiseaseSubstance-Related Disorders

ANO4 CSMD3 TENM2 FAAH TIAM2

2.34e-041151415C0236969
DiseaseDrug Use Disorders

ANO4 CSMD3 TENM2 FAAH TIAM2

2.34e-041151415C0013222
DiseaseDrug Dependence

ANO4 CSMD3 TENM2 FAAH TIAM2

2.34e-041151415C1510472
DiseaseSubstance Dependence

ANO4 CSMD3 TENM2 FAAH TIAM2

2.34e-041151415C0038580
DiseaseSubstance Use Disorders

ANO4 CSMD3 TENM2 FAAH TIAM2

2.34e-041151415C0038586
DiseaseOrganic Mental Disorders, Substance-Induced

ANO4 CSMD3 TENM2 FAAH TIAM2

2.34e-041151415C0029231
DiseaseSubstance abuse problem

ANO4 CSMD3 TENM2 FAAH TIAM2

2.43e-041161415C0740858
Diseaseneutrophil count

TSPAN15 MAGI1 COL11A1 POLR3GL DARS1 CHRNB2 NLRP3 RRAGC THEM4 MARK4 UGCG BTN2A3P CHEK2 PAK2 AKAP10 UNC13C KDM4B

3.33e-04138214117EFO_0004833
Diseasemetabolite measurement

DPYS COL11A1 SPTA1 BAAT ATP10D FAAH TUBGCP6 SLC6A12 THEM4 TTC38

3.75e-0456014110EFO_0004725
DiseaseCOVID-19, obesity

ADCY3 ADCY8

4.69e-0471412EFO_0001073, MONDO_0100096
Diseaseglycosyl-N-behenoyl-sphingadienine (d18:2/22:0) measurement

ATP10D TXK

4.69e-0471412EFO_0800520
Diseaseaflatoxins-related hepatocellular carcinoma (biomarker_via_orthology)

GGT2P GGT3P

4.69e-0471412DOID:5022 (biomarker_via_orthology)
Diseasecesarean section, Self-injurious behavior

ANPEP CELSR1 EXOC4

4.79e-04321413EFO_0009636, HP_0100716
Diseaseage at first sexual intercourse measurement

SEMA3F TENM2 TENM4 SUMF1 BTN1A1 KDM4B EXOC4 BRWD1

5.30e-043831418EFO_0009749
Diseasereticulocyte measurement

TSPAN15 SEMA3F SPTA1 PSMB5 RFC1 ADCY3 ADCY8 MARK4 USP32 EIF4G1 VPS13A CHEK2 PAK2 CFAP70

5.39e-04105314114EFO_0010700
Diseasepneumococcal meningitis

CELSR1 ROS1

6.23e-0481412EFO_1001114
Diseasealcohol dependence (biomarker_via_orthology)

GGT2P GGT3P

6.23e-0481412DOID:0050741 (biomarker_via_orthology)
Diseasenon-alcoholic fatty liver disease (implicated_via_orthology)

NLRP3 SLC7A3 ALDH1L2

6.79e-04361413DOID:0080208 (implicated_via_orthology)
Diseaseglycosyl-N-palmitoyl-sphingosine (d18:1/16:0) measurement

ATP10D TXK

7.98e-0491412EFO_0800476
Diseasehemoglobin A1 measurement

SPTA1 ITSN1 PSMB5 GSAP RFC1 KLHL21 VPS13A PAK2 APOBEC3C

9.18e-045201419EFO_0007629
DiseaseParkinson's disease (implicated_via_orthology)

PAK4 IGF1R EIF4G1 VPS13A VPS41

9.67e-041571415DOID:14330 (implicated_via_orthology)
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

EPPK1 ANPEP LRRC43 MARK4 CHEK2 PRKCA

1.05e-032391416EFO_0010934
DiseaseQT interval

ITSN1 HLF FAM13B SLC2A5 AOPEP PRKCA ROS1 EXOC4 BRWD1

1.11e-035341419EFO_0004682
Diseaseinsulin sensitivity measurement, glucose homeostasis measurement

PAK2 UNC13C PLCE1

1.15e-03431413EFO_0004471, EFO_0006896
DiseaseJT interval

FAM13B IGF1R AOPEP PRKCA CFAP70 BRWD1

1.26e-032481416EFO_0007885
Diseaseanthropometric measurement

NPR3 COL11A1 TENM2 IGF1R DUSP29

1.31e-031681415EFO_0004302
Diseaseempathy measurement

ZCCHC9 DYSF TENM4 METTL9 SUMF1

1.38e-031701415EFO_0009183
Diseaseprogression free survival, urinary bladder cancer

IFT140 TENM4

1.45e-03121412EFO_0004920, MONDO_0001187
Diseasemonocyte count

GALNT1 SPTA1 OSER1 DARS1 WNK1 RYR1 CHRNB2 ZFYVE28 THEM4 CIITA MARK4 BTN2A3P PAK2 KDM4B PLCE1

1.66e-03132014115EFO_0005091
DiseaseMalignant neoplasm of breast

COL11A1 CD109 BCAR1 DYSF WNK1 MAP3K6 APOBEC3B FAAH SLC2A5 METTL6 IGF1R CHEK2 DOP1A

1.97e-03107414113C0006142
DiseaseTubular Aggregate Myopathy

CASQ1 RYR1

1.99e-03141412C0410207
DiseaseColorectal Carcinoma

UNC13B CD109 WNK1 CSMD3 ADCY8 EIF4G1 VPS13A CHEK2 OLFM2 EXOC4

2.07e-0370214110C0009402
Diseasewaist-hip ratio

COL5A1 NPR3 COL11A1 CEP192 WNK1 ADCY3 ADCY8 PPP2R3A IGF1R UBN1 CIITA RNF146 OLFM2 PLCE1

2.27e-03122614114EFO_0004343
Diseasesuperior parietal cortex volume measurement

GALNT1 UGCG

2.29e-03151412EFO_0010330
DiseaseAntithrombotic agent use measurement

TDRD15 BCAR1 AOPEP

2.34e-03551413EFO_0009925
Diseaseocular sarcoidosis

MAGI1 GGT2P IGF1R USP32

2.37e-031161414EFO_0010723
Diseasealcohol use disorder (implicated_via_orthology)

UNC13B RYR1 CHRNB2 PRKCA UNC13C

2.51e-031951415DOID:1574 (implicated_via_orthology)
Diseasesexual dimorphism measurement

SEMA3F NPR3 EPPK1 MAP1LC3A LRRC43 DYSF GSDMC ADCY3 ADCY8 IGF1R UBN1 AOPEP BTN1A1

2.54e-03110614113EFO_0021796
DiseaseDiabetic Angiopathies

ADCY3 ADCY8

2.60e-03161412C0011875
DiseaseMicroangiopathy, Diabetic

ADCY3 ADCY8

2.60e-03161412C0025945
Diseasepreeclampsia, hypertension, pregnancy-induced

NPR3 PLCE1

2.60e-03161412EFO_0000668, MONDO_0024664
Diseasethyroid volume

IGF1R DNAH5

2.60e-03161412EFO_0004865
DiseaseWithdrawal Symptoms

ADCY8 CHRNB2 FAAH

2.72e-03581413C0087169
DiseaseDrug Withdrawal Symptoms

ADCY8 CHRNB2 FAAH

2.72e-03581413C0086189
DiseaseSubstance Withdrawal Syndrome

ADCY8 CHRNB2 FAAH

2.72e-03581413C0038587
DiseaseAlzheimer disease, brain volume measurement

ADCY8 PAK2

2.94e-03171412EFO_0006930, MONDO_0004975
Diseasehypertrophic cardiomyopathy (is_marker_for)

MAP1LC3A IGF1R

2.94e-03171412DOID:11984 (is_marker_for)
Diseaseserum alanine aminotransferase measurement

ANPEP MAP1LC3A LRRC43 NLRP3 ATP10D TENM4 MARK4 CHEK2 PRKCA PLCE1 BRWD1

3.11e-0386914111EFO_0004735
Diseaseischemia (biomarker_via_orthology)

MAP1LC3A PRKCA

3.30e-03181412DOID:326 (biomarker_via_orthology)
Diseaseasthma

MAGI1 GSAP RFC1 DYSF CSMD3 TIAM2 USP32 TRPM8 UNC13C OSTF1

3.35e-0375114110MONDO_0004979
DiseaseAstigmatism

MAGI1 EIF3E TENM2 DNAH5

3.47e-031291414HP_0000483
Diseaseplatelet component distribution width

SPTA1 HLF OSER1 WNK1 TXK IGF1R MARK4 CHEK2 PAK2 BRWD1

3.48e-0375514110EFO_0007984
Diseasediffuse plaque measurement

ANO4 COL5A1 CD109 CUL7 CSMD3 RRAGC METTL6 TENM4 ANXA10 AIPL1

3.57e-0375814110EFO_0010699
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Positive

ZFC3H1 DYSF IGF1R AOPEP

3.66e-031311414C4704862
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Negative

ZFC3H1 DYSF IGF1R AOPEP

3.66e-031311414C4552091
DiseaseJuvenile arthritis

ZFC3H1 DYSF IGF1R AOPEP

3.66e-031311414C3495559
DiseaseJuvenile psoriatic arthritis

ZFC3H1 DYSF IGF1R AOPEP

3.66e-031311414C3714758
DiseaseJuvenile-Onset Still Disease

ZFC3H1 DYSF IGF1R AOPEP

4.08e-031351414C0087031
DiseaseNonorganic psychosis

TENM4 PRKCA APOBEC3C

4.45e-03691413C0349204
Diseasewaist circumference

HLF CWC22 ADCY3 ADCY8 PPP2R3A UNC13C DNAH5

4.67e-034291417EFO_0004342

Protein segments in the cluster

PeptideGeneStartEntry
FLDYEAGDVSFYNMR

BTN2A3P

421

Q96KV6
EELYSQSYDAVGVMF

ADCY8

971

P40145
DYLFGKEMYQVDFLD

ACTR6

76

Q9GZN1
FDVEEFMYLVLQAAD

EOGT

496

Q5NDL2
LEDENGDMFYSQAHY

BAAT

36

Q14032
MFAYHTLGYEDLDEL

AIPL1

126

Q9NZN9
DMVDAINECYDGYFQ

ANXA10

221

Q9UJ72
FQMEEKYDYLEIEGS

CSMD3

286

Q7Z407
AGARVTIMDYEEFAY

APOBEC3B

141

Q9UH17
LDYESGDISFYNMND

BTN1A1

426

Q13410
MEDYDYVHLQGKEEF

BCAR1

661

P56945
FYFSEYMEKEDAVNI

AKAP10

391

O43572
YDQMDLAGEEEIELY

CIITA

51

P33076
VFTDVEDYMYLAKEE

ALDH1L2

811

Q3SY69
RTFQDEYEISEMVGY

GSDMC

236

Q9BYG8
GYFDEEMAVKYISEV

MASTL

126

Q96GX5
EGVAVEIMDYEDFKY

APOBEC3C

141

Q9NRW3
YFILDEFLMGGDVQD

AP1S1

111

P61966
EEGSEYYERTNMLLE

DOP1A

156

Q5JWR5
LADDLAGFYRSEYME

ANPEP

186

P15144
ERFLQEDQAMGVYLY

AOPEP

766

Q8N6M6
EEERVSYYMEGLFDE

CELSR1

276

Q9NYQ6
AYGLFDEYLEMILQF

ANO4

706

Q32M45
MEEEDLAEYFRLQYG

CCDC42

6

Q96M95
FFDAEDYYIVLELME

CHEK2

291

O96017
DYYIVLELMEGGELF

CHEK2

296

O96017
YFIQSDVDFYNEKMD

ATP10D

401

Q9P241
EDYVNMFVEGFHDAI

NPR3

351

P17342
AAIQEEMGAYGYEDL

OLFM2

161

O95897
GLDYEETAFYEMEVQ

PCDHGA7

306

Q9Y5G6
GALSMFELEYFYEEQ

PPP2R3B

406

Q9Y5P8
LDFGYLTQDMIDDYE

ZFYVE28

206

Q9HCC9
DVDYDEELYVAGNMV

ANAPC1

86

Q9H1A4
TYEMLAIEGAQAFYN

GGT3P

216

A6NGU5
EYNMDLYVLRLAEDG

MAGI1

1171

Q96QZ7
EGFVVMQSNDVDIYY

KIAA1109

281

Q2LD37
DLYMVTDLELYEAFS

DPYS

166

Q14117
MAGLLENYYEFFENE

FAM13B

201

Q9NYF5
YMESFEGIFKEQYDT

CWC22

521

Q9HCG8
NIVDDFQEYNYGTME

COL11A1

301

P12107
YDGYEISEDSFFQNM

ECE2

561

P0DPD6
IGDFGMTRDIYETDY

IGF1R

1151

P08069
EAEGAGEMLEFDYEY

MAP3K6

631

O95382
GEMLEFDYEYTETGE

MAP3K6

636

O95382
ENEDLYYEGAMPEVS

CUL7

1376

Q14999
EDMDLYSINYLHFGE

KDM4B

191

O94953
EDMDLYSINYLHFGE

KDM4E

191

B2RXH2
MYNDYYVLDDAVFVL

METTL9

301

Q9H1A3
RDAYGEFMIQVNHEY

TUBGCP6

546

Q96RT7
YDGDTFQLEYMDLEE

HLF

76

Q16534
VDGDGVLSMYELEYF

PPP2R3A

986

Q06190
FMDTGYEEVVNEYVF

METTL6

231

Q8TCB7
DSYLVGDELFVVMEY

PAK2

311

Q13177
DYFQEIGTYDAGMDI

GALNT1

301

Q10472
DYQVMDEFLYNLSSD

DNAH1

891

Q9P2D7
IQFYADESYNLMFEV

GSAP

236

A4D1B5
EGNYAIVANVESMDY

EXOC4

796

Q96A65
IDGVYDNAEYAERFM

CD109

651

Q6YHK3
LMYFVRDDSAEVDVY

KLHL21

471

Q9UJP4
YRDMDIQYHGVEADD

DUSP29

101

Q68J44
MGQLYEDNHEEDYFL

GABARAPL1

91

Q9H0R8
EVNENFEMAAAYYKE

CFAP70

646

Q5T0N1
YFLSYRMIGADVEFE

FRRS1L

121

Q9P0K9
VDSMYVFKGDEVIEY

CASQ1

126

P31415
GDVSLQEYYMDVAFL

COL6A5

2281

A8TX70
QEYYMDVAFLIDASQ

COL6A5

2286

A8TX70
IGMYDYTAQNDDELA

ITSN1

1161

Q15811
DEELYSQTYDEIGVM

ADCY3

911

O60266
QYIAEDYFMAKAIAD

UGCG

231

Q16739
YVDYADGMEEIFGSL

COL5A1

1601

P20908
VDFAMDVYKNLYSDD

EIF3E

51

P60228
MGDEVIYFRQGHEAY

BRWD1

961

Q9NSI6
YQGLYEILELAEDME

EIF4G1

1316

Q04637
NKDGYIDFMEYVAAL

GUCA1A

66

P43080
LYLVMEYASAGEVFD

MARK4

131

Q96L34
MFYDDHLEAYFEQLA

CEP192

221

Q8TEP8
YEQVMIAALDYGRDD

EMC2

56

Q15006
DEAQMEHYRGYFGDI

FAAH

516

O00519
LLFQMAESVDYDYDV

DHX40

291

Q8IX18
AEYQAYIDFEMKIGD

SART3

311

Q15020
EGDEDENMVYYFLEE

RYR1

4621

P21817
VELYDHDTYGADEFM

DYSF

1226

O75923
ESQGEMDAALHYYEL

IFT140

966

Q96RY7
EEDYELAMAELNDTY

SLC7A3

221

Q8WY07
IAESYFQEEDYEKAM

CNST

196

Q6PJW8
MFYYQDVEEAETGQL

DNAH5

81

Q8TE73
TYEMLAIEGAQAFYN

GGT2P

216

P36268
YVTYDFVKDEEGEMN

LRRC43

341

Q8N309
MAEIYRDYKDEDGFV

MAP1LC3C

101

Q9BXW4
LYFEEGDIIYITDMS

OSTF1

31

Q92882
ENVVEMYNSYLVGDE

PAK4

376

O96013
EVYFMGLIDILTQYD

PIP4K2C

366

Q8TBX8
QEFFAAMYYLLEEEK

NLRP3

526

Q96P20
ETDYIMSYFDNGEDF

POLR3GL

191

Q9BT43
DVDDGMLYEFFVKVY

TRNAU1AP

106

Q9NX07
IYVIDAQDDYMEALT

RRAGC

141

Q9HB90
ELYHEGEQVEYAEMV

WRAP53

201

Q9BUR4
EELYAGVYIDFMGTD

SEMA3F

216

Q13275
FFAENEGLDDYMEAR

TMEM151B

256

Q8IW70
FVEYFALDLLMENGE

SDHA

216

P31040
VQMEIEAAYIAFIAY

TDRD15

476

B5MCY1
MLQAGYAEYFQVELE

TDRD15

656

B5MCY1
DRLYFVMEYVNGGDL

PRKCA

411

P17252
YDMELGEEFYLDQNK

PLCE1

1641

Q9P212
DGVQDVVALMDTYYL

RFC1

1016

P35251
NETYYGRTGEFMEDF

SLC2A5

51

P22732
VDVAYRRGYFDEEMN

EPPK1

3426

P58107
YGADRFYDNIEDMIG

SLC6A12

476

P48065
AGFLYVADLENMVQY

RNF146

141

Q9NTX7
EEGMVNARFDYTYHD

TENM2

2081

Q9NT68
EIMDAAEDYAKERYG

DARS1

16

P14868
EDMAIDYESFYVYAQ

POLA2

516

Q14181
QEKDEDGFLYMVYAS

MAP1LC3A

101

Q9H492
VDDVTIEDLSGYMEY

OSER1

261

Q9NX31
IDAFYMDAYEVSNTE

SUMF1

121

Q8NBK3
DVVLYNNADGMYEVS

CHRNB2

116

P17787
YDEQVDFYGSSMEEF

ZBTB43

311

O43298
GHRYFYEMDEVEGET

ZNF451

556

Q9Y4E5
CQLELEVHYYNEMFG

VPS13A

1766

Q96RL7
VDEFAMRYGIESIYQ

UNC13C

1406

Q8NB66
NEMQKIYEDYGTVFD

TIAM2

1291

Q8IVF5
DDGLGFEYVMFYNDI

THEM4

116

Q5T1C6
NEFAGIEMTYETYER

SYCP2

1351

Q9BX26
GIENYYDDLDFKNIM

TSPAN15

131

O95858
EAMQALFVSSDYYNE

TCN1

246

P20061
YVVGKMFVDVYFQED

PHEX

416

P78562
FTEEGMVNARFDYNY

TENM4

2071

Q6N022
ADNEMGYYAEGDSLF

ROS1

1191

P08922
VDEFAMRYGIESIYQ

UNC13B

786

O14795
RYNEFLLAYEAGDML

SPTA1

1081

P02549
LDYEAGMVSFYNITD

TRIM21

411

P19474
YEMILHEFLESDYEG

VPS41

461

P49754
YGEVFADQIDLYAME

TRPM1

1011

Q7Z4N2
ISDFGMTRYVLDDEY

TXK

406

P42681
YSFGLMETNFYDQAE

TTC38

186

Q5R3I4
RIQDLIDMGYGYDES

UBN1

121

Q9NPG3
EYLNEDVNGFMEYLR

ZCCHC9

66

Q8N567
FEYVTAANYFGEIME

SRD5A1

191

P18405
EEKYDESVDVYAFGM

WNK1

396

Q9H4A3
DAEGYFLAQYLMDDF

TRPM8

231

Q7Z2W7
GVMDRGYSYDLEVEQ

PSMB5

196

P28074
DYDQGLLIFYNADDM

TRIM62

421

Q9BVG3
GIYQYDNYEEVAMDT

ZFC3H1

521

O60293
AFTSEEELGENEMYY

USP32

1241

Q8NFA0
EIDDMYTPAYGDFDF

MYORG

351

Q6NSJ0
DYFVDHMGDYEDVLA

NECAB2

121

Q7Z6G3