Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G-protein beta/gamma-subunit complex binding	GNA14 GNA11 GNAQ	5.66e-05	25	60	3	GO:0031683
GeneOntologyMolecularFunction	alkylglycerophosphoethanolamine phosphodiesterase activity	GNA11 GNAQ	8.83e-05	5	60	2	GO:0047391
GeneOntologyBiologicalProcess	phospholipase C-activating dopamine receptor signaling pathway	GNA14 GNA11 GNAQ	1.84e-06	9	59	3	GO:0060158
GeneOntologyBiologicalProcess	G protein-coupled dopamine receptor signaling pathway	GNA14 GNA11 GNAQ DTNBP1	7.52e-06	44	59	4	GO:0007212
GeneOntologyBiologicalProcess	cellular response to dopamine	GNA14 GNA11 GNAQ DTNBP1	3.37e-05	64	59	4	GO:1903351
GeneOntologyBiologicalProcess	response to dopamine	GNA14 GNA11 GNAQ DTNBP1	3.81e-05	66	59	4	GO:1903350
GeneOntologyBiologicalProcess	cellular response to monoamine stimulus	GNA14 GNA11 GNAQ DTNBP1	4.29e-05	68	59	4	GO:0071868
GeneOntologyBiologicalProcess	cellular response to catecholamine stimulus	GNA14 GNA11 GNAQ DTNBP1	4.29e-05	68	59	4	GO:0071870
GeneOntologyBiologicalProcess	response to catecholamine	GNA14 GNA11 GNAQ DTNBP1	5.67e-05	73	59	4	GO:0071869
GeneOntologyBiologicalProcess	response to monoamine	GNA14 GNA11 GNAQ DTNBP1	5.98e-05	74	59	4	GO:0071867
GeneOntologyBiologicalProcess	regulation of melanocyte differentiation	GNA11 GNAQ	1.67e-04	7	59	2	GO:0045634
GeneOntologyBiologicalProcess	regulation of pigment cell differentiation	GNA11 GNAQ	2.86e-04	9	59	2	GO:0050932
GeneOntologyCellularComponent	heterotrimeric G-protein complex	GNA14 GNA11 GNAQ	1.38e-04	35	60	3	GO:0005834
GeneOntologyCellularComponent	GTPase complex	GNA14 GNA11 GNAQ	2.22e-04	41	60	3	GO:1905360
GeneOntologyCellularComponent	extrinsic component of cytoplasmic side of plasma membrane	GNA14 GNA11 GNAQ	5.59e-04	56	60	3	GO:0031234
GeneOntologyCellularComponent	extrinsic component of plasma membrane	GNA14 GNA11 GNAQ DNAJC6	6.48e-04	137	60	4	GO:0019897
HumanPheno	Choroidal melanoma	GNA11 GNAQ	6.98e-05	5	14	2	HP:0012054
HumanPheno	Ciliary body melanoma	GNA11 GNAQ	6.98e-05	5	14	2	HP:0012055
HumanPheno	Iris melanoma	GNA11 GNAQ	6.98e-05	5	14	2	HP:0011524
HumanPheno	Abnormal visual accommodation	GNA11 GNAQ	6.98e-05	5	14	2	HP:0030800
HumanPheno	Inferior lens subluxation	GNA11 GNAQ	6.98e-05	5	14	2	HP:0008494
HumanPheno	Abnormal ciliary body morphology	GNA11 GNAQ	1.05e-04	6	14	2	HP:0012776
HumanPheno	Uveal melanoma	GNA11 GNAQ	1.95e-04	8	14	2	HP:0007716
Domain	Gprotein_alpha_Q	GNA14 GNA11 GNAQ	1.20e-07	4	59	3	IPR000654
Domain	G-alpha	GNA14 GNA11 GNAQ	1.63e-05	16	59	3	PF00503
Domain	GproteinA_insert	GNA14 GNA11 GNAQ	1.63e-05	16	59	3	IPR011025
Domain	-	GNA14 GNA11 GNAQ	1.63e-05	16	59	3	1.10.400.10
Domain	G_alpha	GNA14 GNA11 GNAQ	1.63e-05	16	59	3	SM00275
Domain	Gprotein_alpha_su	GNA14 GNA11 GNAQ	1.97e-05	17	59	3	IPR001019
Domain	ZINC_FINGER_C2H2_2	ZC3H7A KLF8 ZNF234 ZNF335 KLF3 ZNF683 ZNF761 ZNF57 ZNF91 ZNF454 ZKSCAN5	2.65e-05	775	59	11	PS50157
Domain	ZINC_FINGER_C2H2_1	ZC3H7A KLF8 ZNF234 ZNF335 KLF3 ZNF683 ZNF761 ZNF57 ZNF91 ZNF454 ZKSCAN5	2.71e-05	777	59	11	PS00028
Domain	Znf_C2H2-like	ZC3H7A KLF8 ZNF234 ZNF335 KLF3 ZNF683 ZNF761 ZNF57 ZNF91 ZNF454 ZKSCAN5	3.38e-05	796	59	11	IPR015880
Domain	Znf_C2H2	ZC3H7A KLF8 ZNF234 ZNF335 KLF3 ZNF683 ZNF761 ZNF57 ZNF91 ZNF454 ZKSCAN5	3.75e-05	805	59	11	IPR007087
Domain	ZnF_C2H2	ZC3H7A KLF8 ZNF234 ZNF335 KLF3 ZNF683 ZNF761 ZNF57 ZNF91 ZNF454 ZKSCAN5	3.88e-05	808	59	11	SM00355
Domain	-	KLF8 ZNF234 ZNF335 KLF3 ZNF683 ZNF761 ZNF57 ZNF91 ZNF454 ZKSCAN5	4.74e-05	679	59	10	3.30.160.60
Domain	zf-C2H2	KLF8 ZNF234 ZNF335 KLF3 ZNF683 ZNF761 ZNF57 ZNF91 ZNF454 ZKSCAN5	5.62e-05	693	59	10	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	KLF8 ZNF234 ZNF335 KLF3 ZNF683 ZNF761 ZNF57 ZNF91 ZNF454 ZKSCAN5	5.69e-05	694	59	10	IPR013087
Domain	-	GNA14 TDRD9 APAF1 DNAH2 DDX3Y GNA11 ABCG2 GNAQ ABCD2	5.17e-04	746	59	9	3.40.50.300
Domain	KRAB	ZNF234 ZNF761 ZNF57 ZNF91 ZNF454 ZKSCAN5	9.11e-04	358	59	6	PS50805
Domain	KRAB	ZNF234 ZNF761 ZNF57 ZNF91 ZNF454 ZKSCAN5	9.11e-04	358	59	6	PF01352
Domain	KRAB	ZNF234 ZNF761 ZNF57 ZNF91 ZNF454 ZKSCAN5	1.06e-03	369	59	6	SM00349
Domain	KRAB	ZNF234 ZNF761 ZNF57 ZNF91 ZNF454 ZKSCAN5	1.08e-03	370	59	6	IPR001909
Domain	P-loop_NTPase	GNA14 TDRD9 APAF1 DNAH2 DDX3Y GNA11 ABCG2 GNAQ ABCD2	1.28e-03	848	59	9	IPR027417
Domain	MAM	MALRD1 MAMDC2	1.29e-03	17	59	2	SM00137
Domain	MAM	MALRD1 MAMDC2	1.45e-03	18	59	2	PF00629
Domain	MAM_dom	MALRD1 MAMDC2	1.45e-03	18	59	2	IPR000998
Domain	MAM_2	MALRD1 MAMDC2	1.45e-03	18	59	2	PS50060
Domain	Wnt	WNT6 WNT8B	1.62e-03	19	59	2	IPR005817
Domain	Wnt_CS	WNT6 WNT8B	1.62e-03	19	59	2	IPR018161
Domain	wnt	WNT6 WNT8B	1.62e-03	19	59	2	PF00110
Domain	WNT1	WNT6 WNT8B	1.62e-03	19	59	2	SM00097
Domain	WNT1	WNT6 WNT8B	1.62e-03	19	59	2	PS00246
Domain	Apc4_WD40_dom	THOC3 WDR17	1.80e-03	20	59	2	IPR024977
Domain	ANAPC4_WD40	THOC3 WDR17	1.80e-03	20	59	2	PF12894
Domain	G-protein_beta_WD-40_rep	APAF1 THOC3 WDR17	2.46e-03	85	59	3	IPR020472
Domain	Laminin_EGF	LAMC3 MEGF10	5.46e-03	35	59	2	PF00053
Domain	EGF_Lam	LAMC3 MEGF10	5.46e-03	35	59	2	SM00180
Domain	Laminin_EGF	LAMC3 MEGF10	6.41e-03	38	59	2	IPR002049
Domain	EGF	MALRD1 SUSD1 LAMC3 MEGF10	6.47e-03	235	59	4	SM00181
Domain	EGF-like_dom	MALRD1 SUSD1 LAMC3 MEGF10	7.91e-03	249	59	4	IPR000742
Domain	EGF_1	MALRD1 SUSD1 LAMC3 MEGF10	8.58e-03	255	59	4	PS00022
Domain	WD40	APAF1 IFT80 THOC3 WDR17	9.05e-03	259	59	4	PF00400
Domain	FERM_M	EPB41L4B FERMT3	9.29e-03	46	59	2	PF00373
Domain	EGF-like_CS	MALRD1 SUSD1 LAMC3 MEGF10	9.30e-03	261	59	4	IPR013032
Domain	EGF_2	MALRD1 SUSD1 LAMC3 MEGF10	9.79e-03	265	59	4	PS01186
Domain	ABC_tran	ABCG2 ABCD2	1.01e-02	48	59	2	PF00005
Domain	ABC_TRANSPORTER_2	ABCG2 ABCD2	1.01e-02	48	59	2	PS50893
Domain	WD40	APAF1 IFT80 THOC3 WDR17	1.02e-02	268	59	4	SM00320
Domain	ABC_TRANSPORTER_1	ABCG2 ABCD2	1.05e-02	49	59	2	PS00211
Domain	-	EPB41L4B FERMT3	1.05e-02	49	59	2	1.20.80.10
Domain	FERM_central	EPB41L4B FERMT3	1.05e-02	49	59	2	IPR019748
Domain	AAA+_ATPase	DNAH2 ABCG2 ABCD2	1.06e-02	144	59	3	IPR003593
Domain	AAA	DNAH2 ABCG2 ABCD2	1.06e-02	144	59	3	SM00382
Domain	WD40_repeat	APAF1 IFT80 THOC3 WDR17	1.07e-02	272	59	4	IPR001680
Domain	FERM_1	EPB41L4B FERMT3	1.09e-02	50	59	2	PS00660
Domain	FERM_2	EPB41L4B FERMT3	1.09e-02	50	59	2	PS00661
Domain	FERM_3	EPB41L4B FERMT3	1.09e-02	50	59	2	PS50057
Domain	Band_41_domain	EPB41L4B FERMT3	1.09e-02	50	59	2	IPR019749
Domain	B41	EPB41L4B FERMT3	1.09e-02	50	59	2	SM00295
Domain	FERM/acyl-CoA-bd_prot_3-hlx	EPB41L4B FERMT3	1.09e-02	50	59	2	IPR014352
Domain	ABC_transporter-like	ABCG2 ABCD2	1.09e-02	50	59	2	IPR003439
Domain	WD_REPEATS_1	APAF1 IFT80 THOC3 WDR17	1.15e-02	278	59	4	PS00678
Domain	WD_REPEATS_2	APAF1 IFT80 THOC3 WDR17	1.17e-02	279	59	4	PS50082
Domain	WD_REPEATS_REGION	APAF1 IFT80 THOC3 WDR17	1.17e-02	279	59	4	PS50294
Domain	Sushi	SUSD1 CSMD2	1.18e-02	52	59	2	PF00084
Pathway	REACTOME_ACETYLCHOLINE_REGULATES_INSULIN_SECRETION	GNA14 GNA11 GNAQ	1.46e-06	8	43	3	MM15032
Pathway	REACTOME_FATTY_ACIDS_BOUND_TO_GPR40_FFAR1_REGULATE_INSULIN_SECRETION	GNA14 GNA11 GNAQ	1.46e-06	8	43	3	M27356
Pathway	REACTOME_FATTY_ACIDS_BOUND_TO_GPR40_FFAR1_REGULATE_INSULIN_SECRETION	GNA14 GNA11 GNAQ	1.46e-06	8	43	3	MM15100
Pathway	REACTOME_ACETYLCHOLINE_REGULATES_INSULIN_SECRETION	GNA14 GNA11 GNAQ	3.13e-06	10	43	3	M1825
Pathway	REACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION	GNA14 GNA11 GNAQ	4.29e-06	11	43	3	M27317
Pathway	REACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION	GNA14 GNA11 GNAQ	4.29e-06	11	43	3	MM15035
Pathway	PID_THROMBIN_PAR4_PATHWAY	GNA14 GNA11 GNAQ	1.17e-05	15	43	3	M138
Pathway	PID_S1P_META_PATHWAY	GNA14 GNA11 GNAQ	3.38e-05	21	43	3	M155
Pathway	WP_PKCGAMMA_CALCIUM_SIGNALING_IN_ATAXIA	GNA14 GNA11 GNAQ	3.91e-05	22	43	3	M39795
Pathway	REACTOME_G_PROTEIN_ACTIVATION	GNA14 GNA11 GNAQ	5.12e-05	24	43	3	M13115
Pathway	PID_S1P_S1P2_PATHWAY	GNA14 GNA11 GNAQ	5.12e-05	24	43	3	M268
Pathway	REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR	GNA14 GNA11 GNAQ	5.12e-05	24	43	3	M18308
Pathway	REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR	GNA14 GNA11 GNAQ	5.12e-05	24	43	3	MM15088
Pathway	REACTOME_G_PROTEIN_ACTIVATION	GNA14 GNA11 GNAQ	5.12e-05	24	43	3	MM14794
Pathway	REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_1	GNA14 GNA11 GNAQ	5.80e-05	25	43	3	MM15056
Pathway	REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_1	GNA14 GNA11 GNAQ	5.80e-05	25	43	3	M811
Pathway	PID_S1P_S1P3_PATHWAY	GNA14 GNA11 GNAQ	9.14e-05	29	43	3	M55
Pathway	REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS	GNA14 GNA11 GNAQ	1.23e-04	32	43	3	MM15148
Pathway	REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS	GNA14 GNA11 GNAQ	1.23e-04	32	43	3	M861
Pathway	WP_POLYCYSTIC_KIDNEY_DISEASE_PATHWAY	WNT6 WNT8B GNA11 GNAQ	1.27e-04	85	43	4	M48315
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY	GNA11 GNAQ	1.35e-04	6	43	2	M47548
Pathway	REACTOME_SIGNAL_AMPLIFICATION	GNA14 GNA11 GNAQ	1.35e-04	33	43	3	MM15020
Pathway	REACTOME_SIGNAL_AMPLIFICATION	GNA14 GNA11 GNAQ	1.35e-04	33	43	3	M9379
Pathway	PID_ARF6_PATHWAY	GNA14 GNA11 GNAQ	1.62e-04	35	43	3	M86
Pathway	REACTOME_COOPERATION_OF_PDCL_PHLP1_AND_TRIC_CCT_IN_G_PROTEIN_BETA_FOLDING	GNA14 GNA11 GNAQ	2.07e-04	38	43	3	M27656
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	GNA14 GNA11 GNAQ	2.24e-04	39	43	3	MM14496
Pathway	REACTOME_CHAPERONIN_MEDIATED_PROTEIN_FOLDING	GNA14 GNA11 GNAQ	2.24e-04	39	43	3	MM15003
Pathway	PID_ER_NONGENOMIC_PATHWAY	GNA14 GNA11 GNAQ	2.41e-04	40	43	3	M41
Pathway	PID_THROMBIN_PAR1_PATHWAY	GNA14 GNA11 GNAQ	3.00e-04	43	43	3	M238
Pathway	KEGG_MEDICUS_REFERENCE_LPA_GNAQ_11_RHOA_SIGNALING_PATHWAY	GNA11 GNAQ	3.23e-04	9	43	2	M47732
Pathway	KEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY	GNA14 GNA11 GNAQ	4.69e-04	50	43	3	M47951
Pathway	KEGG_MEDICUS_REFERENCE_KISS1_KISS1R_PLCB_PKC_SIGNALING_PATHWAY	GNA11 GNAQ	4.91e-04	11	43	2	M47637
Pathway	KEGG_MEDICUS_REFERENCE_TRH_TRHR_PLCB_PKC_SIGNALING_PATHWAY	GNA11 GNAQ	5.88e-04	12	43	2	M47649
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	GNA14 GNA11 GNAQ	5.88e-04	54	43	3	M26911
Pathway	PID_TXA2PATHWAY	GNA14 GNA11 GNAQ	6.55e-04	56	43	3	M99
Pathway	WP_CANCER_PATHWAYS	TRAF1 WNT6 WNT8B APAF1 GNA11 LAMC3 GNAQ	7.82e-04	507	43	7	M48302
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	GNA14 GNA11 GNAQ	8.41e-04	61	43	3	MM15071
Pathway	PID_ENDOTHELIN_PATHWAY	GNA14 GNA11 GNAQ	9.24e-04	63	43	3	M8
Pathway	PID_LYSOPHOSPHOLIPID_PATHWAY	GNA14 GNA11 GNAQ	1.01e-03	65	43	3	M15
Pathway	REACTOME_OPIOID_SIGNALLING	GNA14 GNA11 GNAQ	1.31e-03	71	43	3	MM14491
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	GNA14 GNA11 GNAQ	1.36e-03	72	43	3	MM14631
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_ACYLATION	WNT6 WNT8B	1.50e-03	19	43	2	M47836
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	GNA14 GNA11 GNAQ	1.72e-03	78	43	3	M1921
Pathway	KEGG_MEDICUS_REFERENCE_GNRH_GNRHR_PLCB_PKC_SIGNALING_PATHWAY	GNA11 GNAQ	1.84e-03	21	43	2	M47638
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	APAF1 GNAQ	2.02e-03	22	43	2	M47690
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY	APAF1 GNAQ	2.02e-03	22	43	2	M47675
Pathway	KEGG_SMALL_CELL_LUNG_CANCER	TRAF1 APAF1 LAMC3	2.12e-03	84	43	3	M3228
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	APAF1 GNAQ	2.21e-03	23	43	2	M47676
Pathway	REACTOME_OPIOID_SIGNALLING	GNA14 GNA11 GNAQ	2.58e-03	90	43	3	M6467
Pathway	WP_G_PROTEIN_SIGNALING_PATHWAYS	GNA14 GNA11 GNAQ	2.58e-03	90	43	3	MM15882
Pathway	REACTOME_WNT_LIGAND_BIOGENESIS_AND_TRAFFICKING	WNT6 WNT8B	2.61e-03	25	43	2	MM14940
Pathway	WP_G_PROTEIN_SIGNALING	GNA14 GNA11 GNAQ	2.66e-03	91	43	3	M39426
Pathway	REACTOME_WNT_LIGAND_BIOGENESIS_AND_TRAFFICKING	WNT6 WNT8B	2.82e-03	26	43	2	M27239
Pathway	WP_SMALL_CELL_LUNG_CANCER	TRAF1 APAF1 LAMC3	3.10e-03	96	43	3	M39834
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_INHIBITOR	WNT6 WNT8B	3.27e-03	28	43	2	M47835
Pathway	REACTOME_PROTEIN_FOLDING	GNA14 GNA11 GNAQ	3.29e-03	98	43	3	M776
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PTCH1_TO_HEDGEHOG_SIGNALING_PATHWAY	WNT6 WNT8B	3.50e-03	29	43	2	M47372
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_SMO_TO_HEDGEHOG_SIGNALING_PATHWAY	WNT6 WNT8B	3.50e-03	29	43	2	M47377
Pathway	KEGG_MELANOGENESIS	WNT6 WNT8B GNAQ	3.58e-03	101	43	3	M7761
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	GNA14 GNA11 GNAQ	4.32e-03	108	43	3	M17034
Pathway	WP_ALSTROM_SYNDROME	CEP192 DTNBP1	4.79e-03	34	43	2	M45524
Pathway	PID_HIV_NEF_PATHWAY	TRAF1 APAF1	5.07e-03	35	43	2	M197
Pathway	KEGG_MEDICUS_VARIANT_FZD7_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY	WNT6 WNT8B	5.66e-03	37	43	2	M47411
Pubmed	High frequency of GNA14, GNAQ, and GNA11 mutations in cherry hemangioma: a histopathological and molecular study of 85 cases indicating GNA14 as the most commonly mutated gene in vascular neoplasms.	GNA14 GNA11 GNAQ	5.39e-09	3	62	3	31189994
Pubmed	Promiscuous coupling of receptors to Gq class alpha subunits and effector proteins in pancreatic and submandibular gland cells.	GNA14 GNA11 GNAQ	2.16e-08	4	62	3	9765251
Pubmed	Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice.	GNA14 GNA11 GNAQ	2.16e-08	4	62	3	9687499
Pubmed	Loss of gq/11 genes does not abolish melanopsin phototransduction.	GNA14 GNA11 GNAQ	5.38e-08	5	62	3	24870805
Pubmed	Using siRNA to define functional interactions between melanopsin and multiple G Protein partners.	GNA14 GNA11 GNAQ	1.07e-07	6	62	3	24958088
Pubmed	Protease-activated receptors in hemostasis, thrombosis and vascular biology.	GNA14 GNA11 GNAQ	4.50e-07	9	62	3	16102047
Pubmed	Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulator.	GNA14 GNA11 GNAQ	4.50e-07	9	62	3	1322796
Pubmed	Analysis of G protein alpha subunit mRNA abundance in preimplantation mouse embryos using a rapid, quantitative RT-PCR approach.	GNA14 GNA11 GNAQ	6.42e-07	10	62	3	8588930
Pubmed	Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.	GNA14 GNA11 GNAQ	2.42e-06	15	62	3	28578927
Pubmed	Mechanism of GTP hydrolysis by G-protein alpha subunits.	GNA14 GNA11 GNAQ	2.42e-06	15	62	3	7937899
Pubmed	Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1).	GNA14 GNA11 GNAQ	2.42e-06	15	62	3	11118617
Pubmed	GNAQ and GNA11 mutations occur in 9.5% of mucosal melanoma and are associated with poor prognosis.	GNA11 GNAQ	3.13e-06	2	62	2	27498141
Pubmed	Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways.	GNA11 GNAQ	3.13e-06	2	62	2	7492305
Pubmed	Reduced trabecular bone mass and strength in mice overexpressing Gα11 protein in cells of the osteoblast lineage.	GNA11 GNAQ	3.13e-06	2	62	2	24308950
Pubmed	The Role of Mutation Rates of GNAQ or GNA11 in Cases of Uveal Melanoma in Japan.	GNA11 GNAQ	3.13e-06	2	62	2	28248732
Pubmed	Gαq and Gα11 contribute to the maintenance of cellular electrophysiology and Ca2+ handling in ventricular cardiomyocytes.	GNA11 GNAQ	3.13e-06	2	62	2	22562663
Pubmed	Uveal Melanoma: GNAQ and GNA11 Mutations in a Greek Population.	GNA11 GNAQ	3.13e-06	2	62	2	28982892
Pubmed	Mutations in GNA11 in uveal melanoma.	GNA11 GNAQ	3.13e-06	2	62	2	21083380
Pubmed	Activation of Gq/11 in the mouse corpus luteum is required for parturition.	GNA11 GNAQ	3.13e-06	2	62	2	25495873
Pubmed	GNAQ and GNA11 mutations in uveal melanoma.	GNA11 GNAQ	3.13e-06	2	62	2	25304237
Pubmed	Functional specificity of G alpha q and G alpha 11 in the cholinergic and glutamatergic modulation of potassium currents and excitability in hippocampal neurons.	GNA11 GNAQ	3.13e-06	2	62	2	11826096
Pubmed	Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes.	GNA11 GNAQ	3.13e-06	2	62	2	28301547
Pubmed	Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation.	GNA11 GNAQ	3.13e-06	2	62	2	16847339
Pubmed	Blue nevi and variants: an update.	GNA11 GNAQ	3.13e-06	2	62	2	21366456
Pubmed	In uveal melanoma Gα-protein GNA11 mutations convey a shorter disease-specific survival and are more strongly associated with loss of BAP1 and chromosomal alterations than Gα-protein GNAQ mutations.	GNA11 GNAQ	3.13e-06	2	62	2	35580369
Pubmed	Gonadotropin and gonadal steroid release in response to a gonadotropin-releasing hormone agonist in Gqalpha and G11alpha knockout mice.	GNA11 GNAQ	3.13e-06	2	62	2	9607776
Pubmed	Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology.	GNA11 GNAQ	3.13e-06	2	62	2	29570931
Pubmed	Muscarinic inhibition of calcium current and M current in Galpha q-deficient mice.	GNA11 GNAQ	3.13e-06	2	62	2	10818132
Pubmed	Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis.	GNA11 GNAQ	3.13e-06	2	62	2	26272756
Pubmed	NK2 receptor-mediated detrusor muscle contraction involves Gq/11-dependent activation of voltage-dependent Ca2+ channels and the RhoA-Rho kinase pathway.	GNA11 GNAQ	3.13e-06	2	62	2	31461351
Pubmed	Ultradeep sequencing detects GNAQ and GNA11 mutations in cell-free DNA from plasma of patients with uveal melanoma.	GNA11 GNAQ	3.13e-06	2	62	2	23634288
Pubmed	Reverse Phenotyping in Patients with Skin Capillary Malformations and Mosaic GNAQ or GNA11 Mutations Defines a Clinical Spectrum with Genotype-Phenotype Correlation.	GNA11 GNAQ	3.13e-06	2	62	2	31726051
Pubmed	Frequent GNAQ and GNA14 Mutations in Hepatic Small Vessel Neoplasm.	GNA14 GNAQ	3.13e-06	2	62	2	29975248
Pubmed	Papillary Hemangioma Harbors Somatic GNA11 and GNAQ Mutations.	GNA11 GNAQ	3.13e-06	2	62	2	37750536
Pubmed	G(alpha)q-deficient mice lack metabotropic glutamate receptor-dependent long-term depression but show normal long-term potentiation in the hippocampal CA1 region.	GNA11 GNAQ	3.13e-06	2	62	2	11438569
Pubmed	GNAQ/GNA11 Mosaicism Is Associated with Abnormal Serum Calcium Indices and Microvascular Neurocalcification.	GNA11 GNAQ	3.13e-06	2	62	2	37802294
Pubmed	Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis.	GNA11 GNAQ	3.13e-06	2	62	2	26778290
Pubmed	Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors.	GNA11 GNAQ	3.13e-06	2	62	2	26628681
Pubmed	CD4 cells can be more efficient at tumor rejection than CD8 cells.	DDX3Y UTY	3.13e-06	2	62	2	17327412
Pubmed	Skeletal Muscle-Specific Activation of Gq Signaling Maintains Glucose Homeostasis.	GNA11 GNAQ	3.13e-06	2	62	2	30936140
Pubmed	Distribution of GNAQ and GNA11 Mutation Signatures in Uveal Melanoma Points to a Light Dependent Mutation Mechanism.	GNA11 GNAQ	3.13e-06	2	62	2	26368812
Pubmed	Postsynaptic mechanisms underlying responsiveness of amygdaloid neurons to cholecystokinin are mediated by a transient receptor potential-like current.	GNA11 GNAQ	3.13e-06	2	62	2	17482476
Pubmed	The time-course of agonist-induced solubilization of trimeric G(q)alpha/G(11)alpha proteins resolved by two-dimensional electrophoresis.	GNA11 GNAQ	3.13e-06	2	62	2	17552882
Pubmed	Patient survival in uveal melanoma is not affected by oncogenic mutations in GNAQ and GNA11.	GNA11 GNAQ	3.13e-06	2	62	2	23778528
Pubmed	High throughput mass spectrometry-based mutation profiling of primary uveal melanoma.	GNA11 GNAQ	3.13e-06	2	62	2	22977135
Pubmed	An experimental strategy to probe Gq contribution to signal transduction in living cells.	GNA11 GNAQ	3.13e-06	2	62	2	33639168
Pubmed	GNAQ and GNA11 mutant nonuveal melanoma: a subtype distinct from both cutaneous and uveal melanoma.	GNA11 GNAQ	3.13e-06	2	62	2	32064597
Pubmed	Mutational analysis of GNAQ and GNA11 to aid therapy management of a choroidal melanoma metastatic to the contralateral orbit.	GNA11 GNAQ	3.13e-06	2	62	2	23572068
Pubmed	Heterogeneity in Mitogen-Activated Protein Kinase (MAPK) Pathway Activation in Uveal Melanoma With Somatic GNAQ and GNA11 Mutations.	GNA11 GNAQ	3.13e-06	2	62	2	31173078
Pubmed	Molecular genetic testing of uveal melanoma from routinely processed and stained cytology specimens.	GNA11 GNAQ	3.13e-06	2	62	2	21945171
Pubmed	Low mutational burden of eight genes involved in the MAPK/ERK, PI3K/AKT, and GNAQ/11 pathways in female genital tract primary melanomas.	GNA11 GNAQ	3.13e-06	2	62	2	25695059
Pubmed	Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations.	GNA11 GNAQ	3.13e-06	2	62	2	24141786
Pubmed	Frequent and Yet Unreported GNAQ and GNA11 Mutations are Found in Uveal Melanomas.	GNA11 GNAQ	3.13e-06	2	62	2	29209985
Pubmed	Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association.	GNA11 GNAQ	3.13e-06	2	62	2	9175863
Pubmed	Group I metabotropic glutamate receptor signaling via Galpha q/Galpha 11 secures the induction of long-term potentiation in the hippocampal area CA1.	GNA11 GNAQ	3.13e-06	2	62	2	12351712
Pubmed	Regulatory effects of the Uty/Ddx3y locus on neighboring chromosome Y genes and autosomal mRNA transcripts in adult mouse non-reproductive cells.	DDX3Y UTY	3.13e-06	2	62	2	32913328
Pubmed	Cardiac remodeling in Gαq and Gα11 knockout mice.	GNA11 GNAQ	3.13e-06	2	62	2	26476043
Pubmed	Recurrent GNA14 mutations in anastomosing haemangiomas.	GNA14 GNAQ	3.13e-06	2	62	2	29574926
Pubmed	The ethnic profile of patients with birthmarks reveals interaction of germline and postzygotic genetics.	GNA11 GNAQ	3.13e-06	2	62	2	28083870
Pubmed	GNA14 and GNAQ somatic mutations cause spinal and intracranial extra-axial cavernous hemangiomas.	GNA14 GNAQ	3.13e-06	2	62	2	38917801
Pubmed	Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation.	GNA11 GNAQ	3.13e-06	2	62	2	37102682
Pubmed	Early-onset hypertension associated with extensive cutaneous capillary malformations harboring postzygotic variants in GNAQ and GNA11.	GNA11 GNAQ	3.13e-06	2	62	2	36440997
Pubmed	Loss of Gq/11 family G proteins in the nervous system causes pituitary somatotroph hypoplasia and dwarfism in mice.	GNA11 GNAQ	3.13e-06	2	62	2	15713647
Pubmed	Distinct roles of Galpha(q) and Galpha11 for Purkinje cell signaling and motor behavior.	GNA11 GNAQ	3.13e-06	2	62	2	15175381
Pubmed	GNAQ and GNA11 mutations in melanocytomas of the central nervous system.	GNA11 GNAQ	3.13e-06	2	62	2	22307269
Pubmed	Gq/11-Dependent Changes in the Murine Ovarian Transcriptome at the End of Gestation.	GNA11 GNAQ	3.13e-06	2	62	2	26843449
Pubmed	Oncogenic GNAQ and GNA11 mutations in uveal melanoma in Chinese.	GNA11 GNAQ	3.13e-06	2	62	2	25280020
Pubmed	Direct targeting of Gαq and Gα11 oncoproteins in cancer cells.	GNA11 GNAQ	3.13e-06	2	62	2	30890659
Pubmed	Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.	GNA14 GNA11 GNAQ	7.01e-06	21	62	3	30270038
Pubmed	Frequent GNAQ, GNA11, and EIF1AX Mutations in Iris Melanoma.	GNA11 GNAQ	9.37e-06	3	62	2	28700778
Pubmed	Dissecting Gq/11-Mediated Plasma Membrane Translocation of Sphingosine Kinase-1.	GNA11 GNAQ	9.37e-06	3	62	2	33003441
Pubmed	P2Y₂ and Gq/G₁₁ control blood pressure by mediating endothelial mechanotransduction.	GNA11 GNAQ	9.37e-06	3	62	2	26168216
Pubmed	Parathyroid-specific double knockout of Gq and G11 alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+ -sensing receptor.	GNA11 GNAQ	9.37e-06	3	62	2	16988000
Pubmed	The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.	GNA11 GNAQ	9.37e-06	3	62	2	10446129
Pubmed	Arginine 313 of the putative 8th helix mediates Gαq/14 coupling of human CC chemokine receptors CCR2a and CCR2b.	GNA14 GNAQ	9.37e-06	3	62	2	30321592
Pubmed	Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences.	GNA11 GNAQ	9.37e-06	3	62	2	8836152
Pubmed	Gqα/G11α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity.	GNA11 GNAQ	9.37e-06	3	62	2	33166186
Pubmed	Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes.	GNA11 GNAQ	9.37e-06	3	62	2	11689889
Pubmed	A network of Krüppel-like Factors (Klfs). Klf8 is repressed by Klf3 and activated by Klf1 in vivo.	KLF8 KLF3	9.37e-06	3	62	2	18687676
Pubmed	Diabetes-related defects in sarcoplasmic Ca2+ release are prevented by inactivation of G(alpha)11 and G(alpha)q in murine cardiomyocytes.	GNA11 GNAQ	9.37e-06	3	62	2	20372981
Pubmed	Population genetic implications from sequence variation in four Y chromosome genes.	DDX3Y UTY	9.37e-06	3	62	2	10861003
Pubmed	Prognostic impact of chromosomal aberrations and GNAQ, GNA11 and BAP1 mutations in uveal melanoma.	GNA11 GNAQ	9.37e-06	3	62	2	28444874
Pubmed	Endocannabinoid-mediated modulation of Gq/11 protein-coupled receptor signaling-induced vasoconstriction and hypertension.	GNA11 GNAQ	9.37e-06	3	62	2	25595485
Pubmed	Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11).	GNA11 GNAQ	9.37e-06	3	62	2	9481484
Pubmed	The orphan receptor GPR139 signals via Gq/11 to oppose opioid effects.	GNA11 GNAQ	9.37e-06	3	62	2	32576659
Pubmed	Heterotrimeric G alpha q/G alpha 11 proteins function upstream of vascular endothelial growth factor (VEGF) receptor-2 (KDR) phosphorylation in vascular permeability factor/VEGF signaling.	GNA11 GNAQ	9.37e-06	3	62	2	12670961
Pubmed	Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development.	GNA11 GNAQ	9.37e-06	3	62	2	17694176
Pubmed	GNAS, GNAQ, and GNA11 alterations in patients with diverse cancers.	GNA11 GNAQ	9.37e-06	3	62	2	30204251
Pubmed	Identification of HRAS mutations and absence of GNAQ or GNA11 mutations in deep penetrating nevi.	GNA11 GNAQ	9.37e-06	3	62	2	23599145
Pubmed	Heterotrimeric G proteins of the Gq/11 family are crucial for the induction of maternal behavior in mice.	GNA11 GNAQ	9.37e-06	3	62	2	15340067
Pubmed	Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential.	GNA11 GNAQ	9.37e-06	3	62	2	30783010
Pubmed	Galphao2 regulates vesicular glutamate transporter activity by changing its chloride dependence.	GNA11 GNAQ	9.37e-06	3	62	2	15872115
Pubmed	Uterine Gαq/11 signaling, in a progesterone-dependent manner, critically regulates the acquisition of uterine receptivity in the female mouse.	GNA11 GNAQ	9.37e-06	3	62	2	31091422
Pubmed	GNA11 and N-RAS mutations: alternatives for MAPK pathway activating GNAQ mutations in primary melanocytic tumours of the central nervous system.	GNA11 GNAQ	9.37e-06	3	62	2	22758774
Pubmed	Regulation of the epithelial Na+ channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Galphaq/11.	GNA11 GNAQ	9.37e-06	3	62	2	21464134
Pubmed	G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.	GNA11 GNAQ	9.37e-06	3	62	2	2123549
Pubmed	G(q/11)α and G(s)α mediate distinct physiological responses to central melanocortins.	GNA11 GNAQ	9.37e-06	3	62	2	26595811
Pubmed	The heterotrimeric G-protein alpha-subunit Galphaq regulates TCR-mediated immune responses through an Lck-dependent pathway.	GNA11 GNAQ	9.37e-06	3	62	2	18991294
Pubmed	Tamoxifen-inducible Cre-mediated recombination in adipocytes.	GNA11 GNAQ	9.37e-06	3	62	2	20715175
Pubmed	Selective inhibition of Cav3.3 T-type calcium channels by Galphaq/11-coupled muscarinic acetylcholine receptors.	GNA11 GNAQ	9.37e-06	3	62	2	17535809
Cytoband	9q21	GNA14 GNAQ	9.79e-05	11	62	2	9q21
Cytoband	Yq11	DDX3Y UTY	1.17e-04	12	62	2	Yq11
Cytoband	Ensembl 112 genes in cytogenetic band chr9q21	GNA14 MAMDC2 GNAQ	2.51e-03	199	62	3	chr9q21
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	KLF8 ZNF234 ZNF335 KLF3 ZNF683 ZNF761 ZNF57 ZNF91 ZNF454 ZKSCAN5	1.02e-05	718	46	10	28
GeneFamily	Zinc fingers C2H2-type\|Kruppel like factors	KLF8 KLF3	9.44e-04	18	46	2	624
GeneFamily	Wnt family\|Endogenous ligands	WNT6 WNT8B	1.05e-03	19	46	2	360
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	CD163L1 MEGF10	2.13e-03	27	46	2	1253
GeneFamily	WD repeat domain containing	APAF1 IFT80 THOC3 WDR17	4.36e-03	262	46	4	362
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	EPB41L4B FERMT3	7.18e-03	50	46	2	1293
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	DDX3Y UTY	7.46e-03	51	46	2	870
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SUSD1 CSMD2	9.25e-03	57	46	2	1179
Coexpression	MIKKELSEN_ES_ICP_WITH_H3K4ME3	ZSWIM9 TRAF1 MAMDC2 DNAH2 CLEC2D ZNF91 ABCD2 ZNF454 ZKSCAN5 MEGF10	1.36e-05	807	60	10	MM855
Coexpression	HEVNER_Y_CHROMOSOME_EXPRESSION	DDX3Y UTY	3.08e-05	4	60	2	MM451
Coexpression	MIKKELSEN_ES_ICP_WITH_H3K4ME3	ZSWIM9 TRAF1 MAMDC2 DNAH2 CLEC2D ABCD2 ZNF454 ZKSCAN5 MEGF10	3.90e-05	728	60	9	M2004
Coexpression	GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_UP	SUSD1 CLEC2D IFT80 GNAQ DNAJC6	4.95e-05	174	60	5	M6877
ToppCell	proximal-Hematologic-Natural_Killer_T-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KCTD6 TRAF1 ZNF683 CEP192 ZNF876P FERMT3	2.79e-07	195	61	6	4d7c2c4d0130c2d46877ff6dd4584525d8f74daf
ToppCell	proximal-3-Hematologic-Natural_Killer_T\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KCTD6 TRAF1 ZNF683 CEP192 ZNF876P FERMT3	2.79e-07	195	61	6	93093545bb23d2619ace029a52cffa1f673a0c2a
ToppCell	proximal-Hematologic-Natural_Killer_T\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KCTD6 TRAF1 ZNF683 CEP192 ZNF876P FERMT3	2.79e-07	195	61	6	3944e4800f5d904d4efa401ce8913ec0e0781211
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBXL22 GNA14 MAMDC2 WNT6 STRA6 LCMT2	2.79e-07	195	61	6	0bdf845939bc4b8cc94f2808aea60f818425b076
ToppCell	facs-MAT-Fat-24m-Lymphocytic-T_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRAF1 TDRD9 CD163L1 DDX3Y DNAJC6	3.44e-06	168	61	5	22fa707689e8d6ca5154103b7374007d644d61c3
ToppCell	facs-GAT-Fat-24m-Lymphocytic-T_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRAF1 TDRD9 CD163L1 DNAJC6 TECPR1	4.31e-06	176	61	5	8caec727acae325a89a560ec44c933a635da496b
ToppCell	facs-GAT-Fat-3m-Lymphocytic-T_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRAF1 TDRD9 CD163L1 FERMT3 TECPR1	5.08e-06	182	61	5	751bd3e3b49de961523e98197688a05c998c121a
ToppCell	3'_v3-bone_marrow-Lymphocytic_T_CD8-Tem/emra_CD8\|bone_marrow / Manually curated celltypes from each tissue	CLEC2D KLF3 DDX3Y ZNF683 UTY	6.42e-06	191	61	5	db7b8f8826bf19d6eeee14319570a9e6e99ab2cb
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD4-T_reg\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRAF1 WNT6 CLEC2D THOC3 ABCD2	7.83e-06	199	61	5	3f4907fa6d81c5691c19e6798145e9f9eccdfd20
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-CD8+_Tcm\|Int-URO / Disease, condition lineage and cell class	TRAF1 CLEC2D ZNF683 LRRN2 THOC3	8.02e-06	200	61	5	9535fd16a962d57e80319bc26093617e04c8b2a8
ToppCell	LPS_only-Unknown-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMC3 CSMD2 ABCD2 WDR17	1.89e-05	115	61	4	ad5298c2ad8bf94fa13c2e50b0799e929473ef59
ToppCell	LPS_only-Unknown\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMC3 CSMD2 ABCD2 WDR17	1.89e-05	115	61	4	7a733f6987b40ec497a03734b79ed5355ad3a2fc
ToppCell	LPS_only-Unknown-Endothelial-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMC3 CSMD2 ABCD2 WDR17	1.89e-05	115	61	4	c67145d3cd9243994a141749b426ff2a6dcc8d93
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-Smooth_Muscle-like_MyoFibroblast\|E16.5-samps / Age Group, Lineage, Cell class and subclass	FBXL22 MAMDC2 ADAMTS14 MEGF10	4.08e-05	140	61	4	5623a0a68403fc00166b7d13d13e184a718d9bdd
ToppCell	PBMC-Mild-cDC_7\|Mild / Compartment, Disease Groups and Clusters	MALRD1 ZNF234 TDRD9 MAMDC2	4.32e-05	142	61	4	58f66f35646f281e64d634e6c26adbd1d4e6c830
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_3\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAMDC2 CSMD2 PAQR3 MEGF10	4.81e-05	146	61	4	2ac9b487a7991fdc15444aeb93533030e09825bb
ToppCell	Int-URO-Lymphocyte-T_NK-CD8_TCM\|Int-URO / Disease, Lineage and Cell Type	TRAF1 CLEC2D ZNF683 LRRN2	6.54e-05	158	61	4	edcc5a26d4571b179f3ae538fed23b661e4677dd
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMK+-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	MRPL30 CLEC2D CSMD2 UTY	7.20e-05	162	61	4	19395bdb282b4a2d88cd33191af12c24a88c3d16
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Colon_normal_tissue-Colon_normal_tissue-6\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CD163L1 MAMDC2 LRRN2 ABCG2	7.20e-05	162	61	4	7f9385aa749bfb2fa9fee6939fe46d946bc21d31
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	TRAF1 CLEC2D ABCD2 UTY	7.20e-05	162	61	4	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TRAF1 TDRD9 CD163L1 FERMT3	7.38e-05	163	61	4	476e94e1d132eaaecb9e376bd32748a75ad22081
ToppCell	5'-Adult-LymphNode-Hematopoietic-T_cells-TRGV5/7_gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MFSD14A CLEC2D ZNF683 ABCD2	7.73e-05	165	61	4	207f9ca8839f54710e2112986def4bc7b0ef1a28
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l22\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TDRD9 DNAJC6 ZNF454 TECPR1	7.92e-05	166	61	4	bcdaab49bde5beba750b76fdcc3781a3c12c4fff
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TDRD9 DNAJC6 ZNF454 TECPR1	7.92e-05	166	61	4	5e3b998d740b24f790fad37350d704ca0ea10b77
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZSWIM9 DNAH2 CLEC2D ZNF683	8.10e-05	167	61	4	063ec29b32e40aaa138a691da3a79ee8eef0c2be
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CLEC2D DDX3Y ZNF683 UTY	8.29e-05	168	61	4	b94b1f37c92e019d01ecfa3b7cc6797b6e4a56ff
ToppCell	390C-Lymphocytic-NK_cells-Proliferating_NK_cell\|390C / Donor, Lineage, Cell class and subclass (all cells)	PHF7 ABCG2 CHRNA10 ESPL1	8.68e-05	170	61	4	5319f73cff64f2bb67472c7156ee1d0f006c6fc0
ToppCell	T_cells-GNLY+GZMB+_T_cells\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	SUSD1 EPB41L4B KLF3 ZNF683	8.88e-05	171	61	4	04c811817cfec45af5f2891793106cc7ddb0300e
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Colon_normal_tissue\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CD163L1 MAMDC2 LRRN2 ABCG2	9.08e-05	172	61	4	94842346c84542a5243bd765e49f4af8bc5182db
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Colon_normal_tissue-Colon_normal_tissue\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CD163L1 MAMDC2 LRRN2 ABCG2	9.08e-05	172	61	4	5d654dd030ed22a701e15c5f09002951d99a52e8
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GNA14 WNT6 IFT80 STRA6	9.50e-05	174	61	4	c58328c2f262506a4518f49f148e29874faf9171
ToppCell	390C-Lymphocytic-NK_cells-Proliferating_NK_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PHF7 ABCG2 CHRNA10 ESPL1	9.92e-05	176	61	4	8813c01ea080f373fe3970c5e1ba4c2dca0f7f02
ToppCell	PND03-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GNA14 SUSD1 DTNBP1 FERMT3	9.92e-05	176	61	4	1f8d5a48fedbb4c86272c9b5a0f1ef573350357b
ToppCell	droplet-Limb_Muscle-nan-21m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPB41L4B WNT6 STRA6 PAQR3	1.01e-04	177	61	4	291231b1520c135e92739e201495fe1935efa927
ToppCell	PCW_13-14-Neuronal-Neuronal_SCP\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	EPB41L4B WNT6 CSMD2 MEGF10	1.01e-04	177	61	4	621dd82f1393c961d4dd7a615aa52c9df9e36336
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-Double_negative_Thymocyte,_DN4_(Cd8-,_Cd4-),_some_undergoing_VDJ_recombination_\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA1671 TDRD9 CD163L1 LRRN2	1.04e-04	178	61	4	408e41c853f608965cef9111fb87fdc311cdc7a8
ToppCell	droplet-Heart-4Chambers-21m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GNA14 EPB41L4B WNT6 DNAJC6	1.04e-04	178	61	4	3e8aacb27ed1a3c3978e21dddddd0828f8000692
ToppCell	390C-Lymphocytic-NK_cells-Proliferating_NK_cell\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	PHF7 ABCG2 CHRNA10 ESPL1	1.06e-04	179	61	4	e67ad7ab04d0c1309296f57c1f53c5ca14c213fe
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	TRAF1 DDX3Y THOC3 UTY	1.11e-04	181	61	4	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-T8_naive-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CLEC2D DDX3Y STRA6 UTY	1.13e-04	182	61	4	3a3ed195c15d33d46a2f395cb93018e4bba28353
ToppCell	BAL-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_activated\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CLEC2D ZNF683 ABCD2 ESPL1	1.20e-04	185	61	4	191d7e9b34bd1598cb4c18e0cb3d018bad83c757
ToppCell	BAL-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_activated-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CLEC2D ZNF683 ABCD2 ESPL1	1.20e-04	185	61	4	99fe59c15c3c0f7afa7e182255e4bacfba346132
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l30\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZSWIM9 EPB41L4B WNT6 ESPL1	1.25e-04	187	61	4	8e8b147258982b359447add5027318f5b6d51963
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPB41L4B WNT6 LRRN2 MEGF10	1.28e-04	188	61	4	502045a39ffb1e92bd9499848368e8fa971edb88
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBXL22 GNA14 MAMDC2 LCMT2	1.36e-04	191	61	4	8e8beb8e8a3b33cac83d3f7ce915a71e3654fdab
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TRAF1 CLEC2D ZNF683 ABCD2	1.36e-04	191	61	4	c7be771543089fc94e5c62fd22f745189642aec3
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBXL22 GNA14 MAMDC2 STRA6	1.36e-04	191	61	4	60bc1f3efa7bbad5cb7944fe5e049ea79cd1745a
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	TRAF1 CLEC2D DDX3Y UTY	1.39e-04	192	61	4	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMH+-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CLEC2D DDX3Y ZNF683 UTY	1.39e-04	192	61	4	fdc741e1846cfd8ed741b160e3c611c310c5d36d
ToppCell	COVID-19_Severe-CD8+_T_activated\|World / disease group, cell group and cell class	KIAA1671 CLEC2D DDX3Y UTY	1.41e-04	193	61	4	ddc1db516568e03be8e82b2ca770c67756418185
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TRAF1 CLEC2D ZNF683 ABCD2	1.41e-04	193	61	4	b9769b45125d2244afe53f9f71c92c04ddccf980
ToppCell	(1)_T_CD8_activated\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	TRAF1 CLEC2D ZNF683 GNAQ	1.47e-04	195	61	4	2253590339b87692d350f9ea3d2aa851179967e1
ToppCell	Tracheal-NucSeq-Stromal-Schwann-Schwann_nonmyelinating\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	WNT6 CSMD2 DNAJC6 MEGF10	1.53e-04	197	61	4	5c88a97e8e23a5cd61885acbe1ef339ae6a1e35a
ToppCell	Tracheal-10x5prime-Immune_Lymphocytic-T-T_CD8-CD8_TRM\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CLEC2D ZNF683 ABCD2 FERMT3	1.56e-04	198	61	4	becd5ae642f8de541ac790fdca45cf6394f05cd4
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD4-T_reg\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRAF1 CLEC2D THOC3 ABCD2	1.56e-04	198	61	4	7608f67959e1cda7b10e57fd3af2f96216ebe7e9
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_TRM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRAF1 CLEC2D ZNF683 ABCD2	1.59e-04	199	61	4	b947ecaf912d97869f6df32736b8c2b2dd695d66
ToppCell	Tracheal-10x5prime-Stromal-Pericyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CD163L1 WNT6 LAMC3 ADAMTS14	1.59e-04	199	61	4	cefc3b50f65e95da850e4720c7b44bf584073491
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRAF1 CLEC2D THOC3 ABCD2	1.62e-04	200	61	4	e0cec0a844b7c1f8edee4c005af27766754e470a
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD8\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRAF1 CLEC2D ZNF683 ABCD2	1.62e-04	200	61	4	02c4169a23e5aaa0d4bfc78b51ba19ce8157dc3e
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD4\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRAF1 CLEC2D THOC3 ABCD2	1.62e-04	200	61	4	9de4d6ebb7e9bee5d811519eb05913ef30f70786
Disease	Phakomatosis cesioflammea	GNA11 GNAQ	3.80e-06	2	58	2	C3838883
Disease	Congenital hemangioma	GNA11 GNAQ	3.80e-06	2	58	2	C0235753
Disease	Port-wine stain with oculocutaneous melanosis	GNA11 GNAQ	3.80e-06	2	58	2	C1274879
Disease	Malignant melanoma of iris	GNA11 GNAQ	3.78e-05	5	58	2	C0346373
Disease	Malignant melanoma of choroid	GNA11 GNAQ	3.78e-05	5	58	2	C0346388
Disease	Congenital Heart Defects	GNA11 GNAQ STRA6	9.01e-05	44	58	3	C0018798
Disease	Uveal melanoma	GNA11 GNAQ	1.06e-04	8	58	2	C0220633
Disease	gout, hyperuricemia	MALRD1 ABCG2	4.48e-04	16	58	2	EFO_0004274, EFO_0009104
Disease	femoral neck bone mineral density	MALRD1 DTNBP1 ESPL1 ZKSCAN5	6.05e-04	196	58	4	EFO_0007785
Disease	cups of coffee per day measurement	ABCG2 STRA6	2.82e-03	40	58	2	EFO_0006782
Disease	valine measurement	MALRD1 ABCG2	2.82e-03	40	58	2	EFO_0009792
Disease	Cutaneous Melanoma	GNA11 GNAQ	2.96e-03	41	58	2	C0151779
Disease	Carcinoma, Transitional Cell	APAF1 ESPL1	2.96e-03	41	58	2	C0007138
Disease	Craniofacial Abnormalities	APAF1 GNAQ STRA6	3.61e-03	156	58	3	C0376634

Protein segments in the cluster

Peptide	Gene	Start	Entry
FRSHRAAQRCHEDWK	CHRNA10	406	Q9GZZ6
SRSKVADCRGHLSWV	APAF1	871	O14727
SHRVSVLSCTKDRTW	CSMD2	2986	Q7Z408
RVKWTRSSAAKRAAC	ABCD2	11	Q9UBJ2
TSFCHQLRWVSKRSF	ABCG2	371	Q9UNQ0
CHDRWSTRNAAVVCK	CD163L1	501	Q9NR16
AAFHRFHWSRCSKLE	ADAMTS14	431	Q8WXS8
RSTTRKVEEHSWFTC	CECR9	151	P0C854
SERRKWIHCFENVTS	GNAQ	211	P50148
HLFSCHRSEKTCRRW	PAQR3	126	Q6TCH7
CTFTQEKRNRSSWHR	MAMDC2	516	Q7Z304
TDILNWFKCTRHRVS	MEGF10	61	Q96KG7
GCTWKFARSDELTRH	KLF3	296	P57682
ASVPWRSHSFCKDRR	KIAA1671	1491	Q9BY89
VWARTKEATSCHRAL	LRRN2	611	O75325
EDTWAALHRRAKDCA	DTNBP1	56	Q96EV8
CSWKFARSDELTRHF	KLF8	311	O95600
HIRSAAERWKAFSTC	OR6Q1	231	Q8NGQ2
HTNLSLRSSSWRKHC	MFSD14A	451	Q96MC6
HFRSTMWRESSAACT	MALRD1	1581	Q5VYJ5
RFCWSRHHDKAISAV	ESPL1	261	Q14674
VSSSKWEDAVRLCRF	IFT80	596	Q9P2H3
CWASIHSRAGREFHK	CPEB3	666	Q8NE35
SERRKWIHCFENVTS	GNA11	211	P29992
SSSRHSWAEFLKFRK	GDF5-AS1	106	Q5U4N7
YRTAKFHSRVSECSW	DNAJC6	116	O75061
VAWRCFTFSKESVRA	CEP192	1541	Q8TEP8
TVEHNWTFCRLARKT	KCTD6	221	Q8NC69
RFERSGHSRWCDKSV	DDX3Y	116	O15523
TKSSITRLWIHECFR	DNAH2	2636	Q9P225
FVFRLDSARTCKHLW	EPB41L4B	341	Q9H329
RSERRKWIHCFESVT	GNA14	206	O95837
KIWRCESNRSHTTIA	UTY	966	O14607
CASLSRSTAFLRWKD	REG3A	146	Q06141
LICTDWIRHKFTRSR	MRPL30	26	Q8TCC3
HSLTRISKFRCVWIE	TDRD9	1161	Q8NDG6
THRDCSSLRSNSKKW	PHF7	281	Q9BWX1
WLKSAFQRSICSRHE	FBXL22	91	Q6P050
IAWSHKDSKRIATCS	WDR17	486	Q8IZU2
TSKHGFLSWARVCLR	STRA6	266	Q9BX79
ASSARHYTERKWICS	CLEC2D	171	Q9UHP7
RRAETVSSCNCKFHW	WNT8B	301	Q93098
ECGKAFRWSRSLNEH	ZNF876P	151	Q49A33
FSWKSSLTCHRRLHS	ZNF761	531	Q86XN6
FVKSSMHLARCRWAS	ZSWIM9	46	Q86XI8
SSRWLLSAAHCFAKK	TMPRSS11B	216	Q86T26
RITSEWNKVRRHSCA	SUSD1	696	Q6UWL2
TWKAIIAARECDRSH	TECPR1	371	Q7Z6L1
AKVHSVAWSCDGRRL	THOC3	56	Q96J01
RFRRWNCSSHSKAFG	WNT6	81	Q9Y6F9
WKITNVTRRCHESAC	TRAF1	271	Q13077
DKTQLHSRWLDSSRC	FERMT3	221	Q86UX7
ICGKRFSWRSNLVSH	ZNF234	656	Q14588
CSAKARHSWTKDRRA	ZC3H7A	731	Q8IWR0
ECGKAFLWSSTLRRH	ZNF91	606	Q05481
KERFSSSSHWKCASL	ZNF454	111	Q8N9F8
KAFTWSSTFREHVRI	ZNF57	371	Q68EA5
RKDDSTLCCWRHSTT	LCMT2	471	O60294
HVRCRHASSFEEWGR	ZNF335	696	Q9H4Z2
AWREREVCHKRFSSS	ZNF683	396	Q8IZ20
SWSCSLFKHLRSHER	ZKSCAN5	811	Q9Y2L8
HRDTATKIAATAWRA	LAMC3	1166	Q9Y6N6