Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transforming growth factor beta receptor activity	TGFBR2 BMPR2 LTBP1	9.76e-05	13	143	3	GO:0005024
GeneOntologyMolecularFunction	intermediate filament binding	NES MTM1 PKP1	1.54e-04	15	143	3	GO:0019215
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	RET TGFBR2 BMPR2 LTBP1 EPHA5	3.64e-04	85	143	5	GO:0019199
GeneOntologyMolecularFunction	transmembrane receptor protein serine/threonine kinase activity	TGFBR2 BMPR2 LTBP1	3.75e-04	20	143	3	GO:0004675
GeneOntologyBiologicalProcess	cardiac ventricle development	ZFPM2 GREB1L TGFBR2 BMPR2 HEG1 CCM2L AP2B1 LTBP1	1.60e-05	161	142	8	GO:0003231
GeneOntologyBiologicalProcess	tricuspid valve morphogenesis	ZFPM2 TGFBR2 BMPR2	1.74e-05	8	142	3	GO:0003186
GeneOntologyBiologicalProcess	tricuspid valve development	ZFPM2 TGFBR2 BMPR2	2.60e-05	9	142	3	GO:0003175
GeneOntologyBiologicalProcess	ventricular septum development	ZFPM2 TGFBR2 BMPR2 HEG1 AP2B1 LTBP1	3.95e-05	91	142	6	GO:0003281
GeneOntologyBiologicalProcess	sensory organ development	NPHP1 GPD2 NES BNC2 FAT3 RET SIX4 TGFBR2 CRYBB3 KMT2C MYO3A BMPR2 GLI2 RP1L1 PCDH15 C3	4.41e-05	730	142	16	GO:0007423
GeneOntologyBiologicalProcess	notochord regression	GLI1 GLI2	4.71e-05	2	142	2	GO:0060032
GeneOntologyBiologicalProcess	cardiac chamber development	ZFPM2 GREB1L TGFBR2 BMPR2 HEG1 CCM2L AP2B1 LTBP1	1.13e-04	212	142	8	GO:0003205
GeneOntologyBiologicalProcess	negative regulation of Rho-dependent protein serine/threonine kinase activity	CHORDC1 HEG1	1.41e-04	3	142	2	GO:2000299
GeneOntologyBiologicalProcess	neuron development	NPHP1 MAP1B TRIO FAT3 TSC2 BCAN RET ZNF804A TIAM2 SYNGAP1 NEK3 MYO3A BMPR2 GLI2 CNTN5 DHFR RP1L1 PCDH15 KNDC1 IGSF9 C3 SAMD14 EPHA5	1.63e-04	1463	142	23	GO:0048666
GeneOntologyBiologicalProcess	developmental growth	GPD2 BNC2 MAP1B CTC1 BCAN SIX4 ZFPM2 TGFBR2 KMT2C BMPR2 HEG1 CCM2L GLI1 GLI2 MTM1 PCDH15 C3	1.80e-04	911	142	17	GO:0048589
GeneOntologyBiologicalProcess	camera-type eye development	NPHP1 GPD2 NES FAT3 RET TGFBR2 CRYBB3 KMT2C BMPR2 RP1L1 C3	1.81e-04	426	142	11	GO:0043010
GeneOntologyBiologicalProcess	cell morphogenesis	NES MAP1B TRIO FAT3 TSC2 BCAN RET TIAM2 SYNGAP1 NEK3 MYO3A BMPR2 HEG1 P2RX7 GLI2 CNTN5 PCDH15 KNDC1 IGSF9 EPHA5	2.00e-04	1194	142	20	GO:0000902
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	MAP1B TRIO FAT3 TSC2 RET TIAM2 SYNGAP1 MYO3A BMPR2 GLI2 CNTN5 PCDH15 KNDC1 IGSF9 EPHA5	2.05e-04	748	142	15	GO:0048667
GeneOntologyCellularComponent	dendrite	CACNA1B MAP1B FAT3 KIF1B ARFGEF2 TSC2 BCAN RET ZNF804A ZWINT SYNGAP1 BMPR2 KNDC1 IGSF9 LTBP1 SAMD14 EPHA5	8.14e-05	858	143	17	GO:0030425
GeneOntologyCellularComponent	dendritic tree	CACNA1B MAP1B FAT3 KIF1B ARFGEF2 TSC2 BCAN RET ZNF804A ZWINT SYNGAP1 BMPR2 KNDC1 IGSF9 LTBP1 SAMD14 EPHA5	8.38e-05	860	143	17	GO:0097447
GeneOntologyCellularComponent	somatodendritic compartment	CACNA1B MAP1B FAT3 KIF1B ARFGEF2 TSC2 BCAN RET ZNF804A TIAM2 ZWINT SYNGAP1 BMPR2 OPTN P2RX7 KNDC1 IGSF9 LTBP1 SAMD14 EPHA5	2.67e-04	1228	143	20	GO:0036477
GeneOntologyCellularComponent	GLI-SUFU complex	GLI1 GLI2	2.76e-04	4	143	2	GO:1990788
GeneOntologyCellularComponent	axon	CACNA1B LDLRAP1 MAP1B KIF1B TSC2 BCAN RET ZNF804A TIAM2 NEK3 BMPR2 OPTN P2RX7 CNTN5 IGSF9 EPHA5	4.02e-04	891	143	16	GO:0030424
GeneOntologyCellularComponent	9+0 non-motile cilium	NPHP1 MAP1B SPTBN5 TTLL6 RP1L1 PCDH15	6.53e-04	153	143	6	GO:0097731
Domain	-	TNPO2 RTTN ARFGEF2 TSC2 ZYG11B HEATR1 RIF1 AP1B1 AP2B1 PKP1	7.79e-06	222	142	10	1.25.10.10
Domain	ARM-like	TNPO2 RTTN ARFGEF2 TSC2 ZYG11B HEATR1 RIF1 AP1B1 AP2B1 PKP1	4.20e-05	270	142	10	IPR011989
Domain	DNase_TatD-rel_CS	TATDN2 TATDN1	5.74e-05	2	142	2	IPR018228
Domain	Clathrin_b-adaptin_app_Ig-like	AP1B1 AP2B1	5.74e-05	2	142	2	IPR013037
Domain	-	AP1B1 AP2B1	5.74e-05	2	142	2	2.60.40.1150
Domain	PH	TRIO KIF1B SH2B1 TIAM2 SYNGAP1 SPTBN5 OSBP APPL1 CYTH4	6.51e-05	229	142	9	PF00169
Domain	TatD_DNase	TATDN2 TATDN1	1.71e-04	3	142	2	PF01026
Domain	AP_complex_bsu_1_2_4	AP1B1 AP2B1	1.71e-04	3	142	2	IPR016342
Domain	B2-adapt-app_C	AP1B1 AP2B1	1.71e-04	3	142	2	PF09066
Domain	TATD_2	TATDN2 TATDN1	1.71e-04	3	142	2	PS01090
Domain	TATD_3	TATDN2 TATDN1	1.71e-04	3	142	2	PS01091
Domain	TatD_family	TATDN2 TATDN1	1.71e-04	3	142	2	IPR001130
Domain	-	LDLRAP1 TRIO KIF1B SH2B1 TIAM2 SYNGAP1 SPTBN5 OSBP MTM1 APPL1 CYTH4	2.02e-04	391	142	11	2.30.29.30
Domain	ARM-type_fold	TNPO2 RTTN ARFGEF2 TSC2 ZYG11B HEATR1 RIF1 AP1B1 AP2B1 PKP1	2.72e-04	339	142	10	IPR016024
Domain	PH	TRIO KIF1B SH2B1 TIAM2 SYNGAP1 SPTBN5 OSBP APPL1 CYTH4	2.81e-04	278	142	9	SM00233
Domain	PH_DOMAIN	TRIO KIF1B SH2B1 TIAM2 SYNGAP1 SPTBN5 OSBP APPL1 CYTH4	2.88e-04	279	142	9	PS50003
Domain	PH_domain	TRIO KIF1B SH2B1 TIAM2 SYNGAP1 SPTBN5 OSBP APPL1 CYTH4	2.96e-04	280	142	9	IPR001849
Domain	B2-adapt-app_C	AP1B1 AP2B1	3.41e-04	4	142	2	SM01020
Domain	B-adaptin_app_sub_C	AP1B1 AP2B1	3.41e-04	4	142	2	IPR015151
Domain	PH_dom-like	LDLRAP1 TRIO KIF1B SH2B1 TIAM2 SYNGAP1 SPTBN5 OSBP MTM1 APPL1 CYTH4	4.20e-04	426	142	11	IPR011993
Domain	Armadillo	TNPO2 AP1B1 AP2B1 PKP1	4.43e-04	47	142	4	IPR000225
Domain	FYrich_C	KMT2B KMT2C	5.65e-04	5	142	2	IPR003889
Domain	FYrich_N	KMT2B KMT2C	5.65e-04	5	142	2	IPR003888
Domain	AP_beta	AP1B1 AP2B1	5.65e-04	5	142	2	IPR026739
Domain	FYRC	KMT2B KMT2C	5.65e-04	5	142	2	SM00542
Domain	FYRN	KMT2B KMT2C	5.65e-04	5	142	2	SM00541
Domain	FYRN	KMT2B KMT2C	5.65e-04	5	142	2	PF05964
Domain	FYRC	KMT2B KMT2C	5.65e-04	5	142	2	PF05965
Domain	FYRC	KMT2B KMT2C	5.65e-04	5	142	2	PS51543
Domain	FYRN	KMT2B KMT2C	5.65e-04	5	142	2	PS51542
Domain	Beta2_adaptin/TBP_C_dom	AP1B1 AP2B1	8.44e-04	6	142	2	IPR012295
Domain	-	AP1B1 AP2B1	8.44e-04	6	142	2	3.30.310.10
Domain	Coatomer/calthrin_app_sub_C	AP1B1 AP2B1	1.56e-03	8	142	2	IPR009028
Domain	Alpha_adaptinC2	AP1B1 AP2B1	2.00e-03	9	142	2	PF02883
Domain	ZF_SWIM	ZSWIM8 ZSWIM2	2.00e-03	9	142	2	PS50966
Domain	Clathrin_a/b/g-adaptin_app_Ig	AP1B1 AP2B1	2.00e-03	9	142	2	IPR008152
Domain	Alpha_adaptinC2	AP1B1 AP2B1	2.00e-03	9	142	2	SM00809
Domain	Znf_SWIM	ZSWIM8 ZSWIM2	2.00e-03	9	142	2	IPR007527
Domain	ARM	AP1B1 AP2B1 PKP1	3.46e-03	40	142	3	SM00185
Domain	TGFB_receptor	TGFBR2 BMPR2	3.60e-03	12	142	2	IPR000333
Domain	Coatomer/clathrin_app_Ig-like	AP1B1 AP2B1	3.60e-03	12	142	2	IPR013041
Domain	PDZ	MYO18A PRX TIAM2 PDZD2 TJP3	4.48e-03	141	142	5	PF00595
Domain	PDZ	MYO18A PRX TIAM2 PDZD2 TJP3	5.49e-03	148	142	5	SM00228
Domain	Clathrin/coatomer_adapt-like_N	AP1B1 AP2B1	5.65e-03	15	142	2	IPR002553
Domain	Adaptin_N	AP1B1 AP2B1	5.65e-03	15	142	2	PF01602
Domain	-	ARFGEF2 CYTH4	5.65e-03	15	142	2	1.10.1000.11
Domain	Sec7	ARFGEF2 CYTH4	5.65e-03	15	142	2	PF01369
Domain	Sec7_alpha_orthog	ARFGEF2 CYTH4	5.65e-03	15	142	2	IPR023394
Domain	-	MYO18A PRX TIAM2 PDZD2 TJP3	5.81e-03	150	142	5	2.30.42.10
Domain	PDZ	MYO18A PRX TIAM2 PDZD2 TJP3	5.97e-03	151	142	5	PS50106
Domain	PDZ	MYO18A PRX TIAM2 PDZD2 TJP3	6.14e-03	152	142	5	IPR001478
Domain	Post-SET_dom	KMT2B KMT2C	6.42e-03	16	142	2	IPR003616
Domain	PostSET	KMT2B KMT2C	6.42e-03	16	142	2	SM00508
Domain	SEC7	ARFGEF2 CYTH4	6.42e-03	16	142	2	PS50190
Domain	Sec7	ARFGEF2 CYTH4	6.42e-03	16	142	2	SM00222
Domain	Sec7_dom	ARFGEF2 CYTH4	6.42e-03	16	142	2	IPR000904
Domain	POST_SET	KMT2B KMT2C	6.42e-03	16	142	2	PS50868
Domain	EF-hand-dom_pair	GPD2 CACNA1B C1orf87 SPEF2 GNPTAB DGKA KASH5	6.43e-03	287	142	7	IPR011992
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	RHBDF1 KMT2B ZNF628 TRIO VWA8 CTC1 RTTN HECTD4 ARFGEF2 TSC2 SLC29A2 TIAM2 KMT2C HEG1 BTBD7 GLI1 HERC2 ESPL1 DOCK6 CYTH4 TJP3 HR	1.49e-09	1105	146	22	35748872
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	BAZ2B AFF3 ZNF318 PIAS1 CDC7 ZNF462 BRCA1 AP1B1 AP2B1	4.53e-07	222	146	9	37071664
Pubmed	SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors.	PIAS1 GLI1 GLI2	7.20e-07	5	146	3	20711444
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	NES ZSWIM8 MAP1B UGGT1 MCM6 ZNF318 HEATR1 RIF1 AP1B1 RNH1 AP2B1 HERC2 COIL ANKRD52	7.30e-07	653	146	14	22586326
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	VWA8 TNPO2 PPP1R12B UGGT1 MYO18A ZYG11B ZNF318 HEATR1 CHORDC1 ZWINT RNH1 CEP112 HERC2 DOCK6	3.89e-06	754	146	14	33060197
Pubmed	Neural Hedgehog signaling maintains stem cell renewal in the sensory touch dome epithelium.	GLI1 GLI2 HR	4.00e-06	8	146	3	26015562
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	KMT2B BCLAF1 KIF1B MYO18A ARFGEF2 TATDN2 ZNF318 RIF1 OSBP MYO3A APPL1 COIL ESPL1 CYTH4	5.24e-06	774	146	14	15302935
Pubmed	The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis.	NES GLI1 GLI2	5.98e-06	9	146	3	11748155
Pubmed	Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction.	SIM1 GLI1 GLI2	8.51e-06	10	146	3	14602680
Pubmed	Developmental expression of Smoc1 and Smoc2 suggests potential roles in fetal gonad and reproductive tract differentiation.	ZFPM2 GLI1 GLI2	8.51e-06	10	146	3	19842175
Pubmed	53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.	CTC1 RIF1 BRCA1	1.17e-05	11	146	3	30022158
Pubmed	Tagging genes with cassette-exchange sites.	BNC2 TNPO2 UGGT1 ARFGEF2 ZNF462 KMT2C RIF1 GLI2 ANKRD52	1.30e-05	335	146	9	15741177
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	GPD2 NES MAP1B VWA8 BCLAF1 HECTD4 MYO18A SIM1 SYNGAP1 ZNF462 AP2B1 EIF2S1 PCDH15 CKAP4 COIL DOCK6	1.36e-05	1082	146	16	38697112
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	LDLRAP1 RET ZNF804A PIAS1 SH2B1 PRX SYNGAP1 GUCY1B2 AP2B1 GLI2	1.49e-05	430	146	10	35044719
Pubmed	Relative Levels of Gli1 and Gli2 Determine the Response of Ventral Neural Stem Cells to Demyelination.	GLI1 GLI2	1.75e-05	2	146	2	33125874
Pubmed	Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling.	GLI1 GLI2	1.75e-05	2	146	2	27893742
Pubmed	TGF-β/Smad2 signalling regulates enchondral bone formation of Gli1+ periosteal cells during fracture healing.	TGFBR2 GLI1	1.75e-05	2	146	2	32997394
Pubmed	Radix Rehmanniae Praeparata promotes bone fracture healing through activation of TGF-β signaling in mesenchymal progenitors.	TGFBR2 GLI1	1.75e-05	2	146	2	32745914
Pubmed	RIF1 counteracts BRCA1-mediated end resection during DNA repair.	RIF1 BRCA1	1.75e-05	2	146	2	23486525
Pubmed	MYO3A Causes Human Dominant Deafness and Interacts with Protocadherin 15-CD2 Isoform.	MYO3A PCDH15	1.75e-05	2	146	2	26841241
Pubmed	Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer.	NES BRCA1	1.75e-05	2	146	2	28439082
Pubmed	Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Antileukemic Effects.	GLI1 GLI2	1.75e-05	2	146	2	25745035
Pubmed	Unique and overlapping GLI1 and GLI2 transcriptional targets in neoplastic chondrocytes.	GLI1 GLI2	1.75e-05	2	146	2	30695055
Pubmed	Intracellular cytosolic complement component C3 regulates cytoprotective autophagy in pancreatic beta cells by interaction with ATG16L1.	ATG16L1 C3	1.75e-05	2	146	2	30741587
Pubmed	Depletion of eIF2·GTP·Met-tRNAi translation initiation complex up-regulates BRCA1 expression in vitro and in vivo.	BRCA1 EIF2S1	1.75e-05	2	146	2	25762631
Pubmed	Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma.	GLI1 GLI2	1.75e-05	2	146	2	12165851
Pubmed	The GLI gene is a member of the Kruppel family of zinc finger proteins.	GLI1 GLI2	1.75e-05	2	146	2	2832761
Pubmed	GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression.	GLI1 GLI2	1.75e-05	2	146	2	32766732
Pubmed	A Critical Function for the Transcription Factors GLI1 and GLI2 in the Proliferation and Survival of Human Mast Cells.	GLI1 GLI2	1.75e-05	2	146	2	35251038
Pubmed	GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter.	GLI1 GLI2	1.75e-05	2	146	2	15175043
Pubmed	Acquired Cystic Kidney Disease-associated Renal Cell Carcinoma (ACKD-RCC) Harbor Recurrent Mutations in KMT2C and TSC2 Genes.	TSC2 KMT2C	1.75e-05	2	146	2	32604168
Pubmed	[Expression and clinical significances of hedgehog signaling pathway in non-Hodgkin's lymphoma].	GLI1 GLI2	1.75e-05	2	146	2	22040957
Pubmed	ARH cooperates with AP-1B in the exocytosis of LDLR in polarized epithelial cells.	LDLRAP1 AP1B1	1.75e-05	2	146	2	21444685
Pubmed	The oncogenic GLI transcription factors facilitate keratinocyte survival and transformation upon exposure to genotoxic agents.	GLI1 GLI2	1.75e-05	2	146	2	23792444
Pubmed	The Autophagy Protein ATG16L1 Is Required for Sindbis Virus-Induced eIF2α Phosphorylation and Stress Granule Formation.	ATG16L1 EIF2S1	1.75e-05	2	146	2	31905741
Pubmed	SH2B1beta adaptor is a key enhancer of RET tyrosine kinase signaling.	RET SH2B1	1.75e-05	2	146	2	17471236
Pubmed	Nuclear receptor coactivator SRC-1 promotes colorectal cancer progression through enhancing GLI2-mediated Hedgehog signaling.	GLI2 NCOA1	1.75e-05	2	146	2	35418691
Pubmed	Protein kinase inhibitor SU6668 attenuates positive regulation of Gli proteins in cancer and multipotent progenitor cells.	GLI1 GLI2	1.75e-05	2	146	2	24418624
Pubmed	Cone dystrophy in patient with homozygous RP1L1 mutation.	RP1L1 PCDH15	1.75e-05	2	146	2	25692141
Pubmed	Overlapping and distinct transcriptional regulator properties of the GLI1 and GLI2 oncogenes.	GLI1 GLI2	1.75e-05	2	146	2	16434164
Pubmed	Multifaceted Functions of Rab23 on Primary Cilium-Mediated and Hedgehog Signaling-Mediated Cerebellar Granule Cell Proliferation.	NES GLI1 GLI2	2.01e-05	13	146	3	34210780
Pubmed	Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase.	MAP1B BCLAF1 RIF1 LTBP1	2.19e-05	39	146	4	25944111
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	GPD2 NES MAP1B BCLAF1 UGGT1 MCM6 LRRC40 ZNF318 HEATR1 RIF1 EIF2S1 PKP1 CKAP4 HERC2 COIL	2.87e-05	1024	146	15	24711643
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	CACNA1B SPEF2 MYO18A CDC7 KMT2C CEP112 CCDC62	2.97e-05	208	146	7	33230847
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	BCLAF1 ARFGEF2 HEATR1 RIF1 AP1B1 APPL1 COIL ESPL1	3.15e-05	288	146	8	23383273
Pubmed	Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation.	SIM1 GLI1 GLI2	3.18e-05	15	146	3	15604102
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	ZSWIM8 ATG16L1 BCLAF1 MTFR1L CDC7 AP1B1 AP2B1 EIF2S1 BTBD7 KNDC1 COIL ESPL1 DOCK6 ANKRD52 TJP3	3.35e-05	1038	146	15	26673895
Pubmed	Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system.	SIM1 GLI1 GLI2	3.90e-05	16	146	3	9655799
Pubmed	Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins.	TSC2 RIF1 BRCA1	3.90e-05	16	146	3	29764992
Pubmed	Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo.	AP2B1 GLI1 GLI2	3.90e-05	16	146	3	17638910
Pubmed	Suppressor of fused controls mid-hindbrain patterning and cerebellar morphogenesis via GLI3 repressor.	NES GLI1 GLI2	4.72e-05	17	146	3	21289193
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	KIF1B ZNF318 SIX4 SIM1 PIAS1 ZNF462 KMT2C BRCA1 GLI1 GLI2 NCOA1 PLAGL2	4.81e-05	709	146	12	22988430
Pubmed	Direct repression of anoctamin 1 (ANO1) gene transcription by Gli proteins.	GLI1 GLI2	5.24e-05	3	146	2	30802137
Pubmed	Fuzzy modeling reveals a dynamic self-sustaining network of the GLI transcription factors controlling important metabolic regulators in adult mouse hepatocytes.	GLI1 GLI2	5.24e-05	3	146	2	26010061
Pubmed	GLI-mediated Keratin 17 expression promotes tumor cell growth through the anti-apoptotic function in oral squamous cell carcinomas.	GLI1 GLI2	5.24e-05	3	146	2	28342001
Pubmed	TGF-Beta Receptor II Is Critical for Osteogenic Progenitor Cell Proliferation and Differentiation During Postnatal Alveolar Bone Formation.	TGFBR2 GLI1	5.24e-05	3	146	2	34630143
Pubmed	The role of GLI-SOX2 signaling axis for gemcitabine resistance in pancreatic cancer.	GLI1 GLI2	5.24e-05	3	146	2	30382189
Pubmed	The effect of C1 inhibitor on intestinal ischemia and reperfusion injury.	SERPING1 C3	5.24e-05	3	146	2	18787060
Pubmed	Effect of Rab23 on the proliferation and apoptosis in breast cancer.	GLI1 GLI2	5.24e-05	3	146	2	26238143
Pubmed	20-αHydroxycholesterol, an oxysterol in human breast milk, reverses mouse neonatal white matter injury through Gli-dependent oligodendrogenesis.	GLI1 GLI2	5.24e-05	3	146	2	37541211
Pubmed	Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis.	GLI1 GLI2	5.24e-05	3	146	2	26193634
Pubmed	The mechanism of epithelial-mesenchymal transition induced by TGF-β1 in neuroblastoma cells.	GLI1 GLI2	5.24e-05	3	146	2	28393230
Pubmed	TGF-β1 promotes cerebral cortex radial glia-astrocyte differentiation in vivo.	NES TGFBR2	5.24e-05	3	146	2	25484855
Pubmed	ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells.	CCDC62 NCOA1	5.24e-05	3	146	2	18563714
Pubmed	Complete loss of function of the ubiquitin ligase HERC2 causes a severe neurodevelopmental phenotype.	BRCA1 HERC2	5.24e-05	3	146	2	27759030
Pubmed	Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.	GLI1 GLI2	5.24e-05	3	146	2	24217340
Pubmed	Gli family members are differentially expressed during the mitotic phase of spermatogenesis.	GLI1 GLI2	5.24e-05	3	146	2	9178901
Pubmed	Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.	GLI1 GLI2	5.24e-05	3	146	2	8378770
Pubmed	Effect of interferon-gamma on complement gene expression in different cell types.	SERPING1 C3	5.24e-05	3	146	2	1531292
Pubmed	The effects of Gli1 and Gli2 on BMP9-induced osteogenic differentiation of mesenchymal stem cells.	GLI1 GLI2	5.24e-05	3	146	2	37478645
Pubmed	Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit.	TGFBR2 AP2B1	5.24e-05	3	146	2	12429842
Pubmed	Hedgehog signalling mediates drug resistance through targeting TAP1 in hepatocellular carcinoma.	GLI1 GLI2	5.24e-05	3	146	2	32108992
Pubmed	Hedgehog signaling through GLI1 and GLI2 is required for epithelial-mesenchymal transition in human trophoblasts.	GLI1 GLI2	5.24e-05	3	146	2	25888497
Pubmed	ZGRF1 promotes end resection of DNA homologous recombination via forming complex with BRCA1/EXO1.	ZGRF1 BRCA1	5.24e-05	3	146	2	34552057
Pubmed	Gli affects the stemness and prognosis of epithelial ovarian cancer via homeobox protein NANOG.	GLI1 GLI2	5.24e-05	3	146	2	33313950
Pubmed	A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene.	GLI1 GLI2	5.24e-05	3	146	2	8387379
Pubmed	Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.	GLI1 GLI2	5.24e-05	3	146	2	16571352
Pubmed	Mutations in SUFU predispose to medulloblastoma.	GLI1 GLI2	5.24e-05	3	146	2	12068298
Pubmed	Different expression patterns of Gli1-3 in mouse embryonic maxillofacial development.	GLI1 GLI2	5.24e-05	3	146	2	22178118
Pubmed	MAP3K10 promotes the proliferation and decreases the sensitivity of pancreatic cancer cells to gemcitabine by upregulating Gli-1 and Gli-2.	GLI1 GLI2	5.24e-05	3	146	2	23178452
Pubmed	Large-scale pan-cancer analysis reveals broad prognostic association between TGF-β ligands, not Hedgehog, and GLI1/2 expression in tumors.	GLI1 GLI2	5.24e-05	3	146	2	32879407
Pubmed	Gli1 is important for medulloblastoma formation in Ptc1+/- mice.	GLI1 GLI2	5.24e-05	3	146	2	15806168
Pubmed	TUSC4 functions as a tumor suppressor by regulating BRCA1 stability.	BRCA1 HERC2	5.24e-05	3	146	2	25480944
Pubmed	SOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Lines.	GLI1 GLI2	5.24e-05	3	146	2	26588701
Pubmed	HERC2 is an E3 ligase that targets BRCA1 for degradation.	BRCA1 HERC2	5.24e-05	3	146	2	20631078
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	VWA8 UGGT1 MCM6 TSC2 HEATR1 MTFR1L CDC7 RIF1 DHFR HERC2 ANKRD52	5.39e-05	606	146	11	36538041
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ABAT MAP1B TRIO KIF1B AFF3 HECTD4 SH2B1 ZNF462 KMT2C BMPR2 PTPRR GLI2 KNDC1 IGSF9 DOCK6 TATDN1 CLBA1 PDZD2	5.56e-05	1489	146	18	28611215
Pubmed	Identification and selected reaction monitoring (SRM) quantification of endocytosis factors associated with Numb.	BCLAF1 AP1B1 AP2B1	5.65e-05	18	146	3	23211419
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NES TRIO BCLAF1 HECTD4 TSC2 ZNF318 SYNGAP1 ZNF462 AP1B1 P2RX7 AP2B1 PPP1R3F APPL1 HERC2	5.81e-05	963	146	14	28671696
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	KMT2B BAZ2B BCLAF1 TNPO2 ZNF318 PSME2 PIAS1 KMT2C BRCA1 AP1B1 RNH1 AP2B1 EIF2S1 NCOA1 PLAGL2	6.64e-05	1103	146	15	34189442
Pubmed	APC sets the Wnt tone necessary for cerebral cortical progenitor development.	NES GLI1 GLI2	6.68e-05	19	146	3	28916710
Pubmed	alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway.	NES GLI1 GLI2	6.68e-05	19	146	3	16543460
Pubmed	A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.	TRIO ZNF462 PCDH15	9.12e-05	21	146	3	24025145
Pubmed	Hedgehog-GLI signaling in Foxd1-positive stromal cells promotes murine nephrogenesis via TGFβ signaling.	RET TGFBR2 GLI1	9.12e-05	21	146	3	29945868
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	CACNA1B ABAT MAP1B TRIO VWA8 BCLAF1 MYO18A ZWINT SYNGAP1 OSBP KNDC1 PKP1 APPL1 CKAP4 COIL	9.48e-05	1139	146	15	36417873
Pubmed	Protein phosphatase 1γ isoforms linked interactions in the brain.	ZNF318 PIAS1 RIF1 BMPR2	9.90e-05	57	146	4	23080069
Pubmed	ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.	TSC2 RET TGFBR2 BRCA1	9.90e-05	57	146	4	23788249
Pubmed	Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.	KMT2B KMT2C	1.04e-04	4	146	2	19221051
Pubmed	Cloning and sequencing of the mouse Gli2 gene: localization to the Dominant hemimelia critical region.	GLI1 GLI2	1.04e-04	4	146	2	9027508
Pubmed	Comparative genomics identification of a novel set of temporally regulated hedgehog target genes in the retina.	GLI1 GLI2	1.04e-04	4	146	2	22281533
GeneFamily	Cadherin related	FAT3 RET PCDH15	8.78e-05	17	94	3	24
GeneFamily	Type 2 receptor serine/threonine kinases	TGFBR2 BMPR2	2.65e-04	5	94	2	346
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	KIF1B SH2B1 TIAM2 OSBP APPL1 CYTH4	7.20e-04	206	94	6	682
GeneFamily	Zinc fingers SWIM-type\|Mitogen-activated protein kinase kinase kinases	ZSWIM8 ZSWIM2	9.40e-04	9	94	2	90
GeneFamily	PDZ domain containing	MYO18A PRX TIAM2 PDZD2 TJP3	1.18e-03	152	94	5	1220
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	MAP1B PPP1R12B TSC2 BRCA1 PPP1R3F	2.55e-03	181	94	5	694
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	KMT2B PPP1R12B TSC2 KMT2C RIF1 BMPR2 BRCA1 ESPL1	7.96e-06	180	146	8	M8239
Coexpression	GSE37534_UNTREATED_VS_PIOGLITAZONE_TREATED_CD4_TCELL_PPARG1_AND_FOXP3_TRASDUCED_UP	ZSWIM8 BAZ2B ZNF318 AP1B1 DHFR PLAGL2 RMND1 CLBA1	1.54e-05	197	146	8	M8980
Coexpression	GSE32986_GMCSF_VS_GMCSF_AND_CURDLAN_HIGHDOSE_STIM_DC_DN	VWA8 PPP1R12B KIF1B RTTN HECTD4 ZNF318 KMT2C BMPR2	1.59e-05	198	146	8	M8624
Coexpression	LAZARO_GENETIC_MOUSE_MODEL_HIGH_GRADE_SMALL_CELL_NEUROENDOCRINE_LUNG_CARCINOMA_UP	NPHP1 CACNA1B ABAT CTC1 ZGRF1 MCM6 LRRC40 SIX4 CDC7 GREB1L RIF1 GALNT9 DHFR SAMD14	2.83e-05	680	146	14	MM456
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAP1B FAT3 PPP1R12B AFF3 ZNF804A ZFPM2 GLI2 CNTN5 LTBP1	1.82e-08	196	146	9	1522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCell	IPF-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	NES SPEF2 AFF3 PRX BMPR2 PCDH15 PKP1 LTBP1 SEC14L1	1.82e-08	196	146	9	8f0f72ead06abe02b575e443552eacc2151077ef
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAP1B FAT3 PPP1R12B AFF3 ZNF804A ZFPM2 GLI2 CNTN5 LTBP1	1.82e-08	196	146	9	1c8294014713684b50885e638668f2ce75f357f0
ToppCell	Parenchyma_COVID-19-Endothelial-TX-Capillary\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	NES AFF3 PRX TGFBR2 BMPR2 HEG1 PKP1 DOCK6 SEC14L1	2.16e-08	200	146	9	6c0498a5868891e8e22c03469d00669b20249b1a
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TRIO BAZ2B SPEF2 KMT2C BMPR2 HEG1 USHBP1 DOCK6 SEC14L1	2.16e-08	200	146	9	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Capillary-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NES AFF3 PRX TGFBR2 BMPR2 HEG1 PKP1 DOCK6 SEC14L1	2.16e-08	200	146	9	7020045b933cb104fb99b79524cb0d4734b8636d
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Capillary\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	NES AFF3 PRX TGFBR2 BMPR2 HEG1 PKP1 DOCK6 SEC14L1	2.16e-08	200	146	9	e9913511a129bb3cee85e7ebf565b951dab91542
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SPEF2 AFF3 PRX NEK3 BMPR2 CCM2L DOCK6 SEC14L1	2.62e-07	194	146	8	68004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPD2 MAP1B UGGT1 KIF1B RET KMT2C RIF1 NCOA1	2.73e-07	195	146	8	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPD2 MAP1B UGGT1 KIF1B RET KMT2C RIF1 NCOA1	2.73e-07	195	146	8	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NES PRX TGFBR2 BMPR2 HEG1 USHBP1 DOCK6 SEC14L1	2.83e-07	196	146	8	d323f7dc41380446e5967c69832bea88351a9331
ToppCell	343B-Endothelial_cells-Endothelial-E-\|343B / Donor, Lineage, Cell class and subclass (all cells)	NES PRX TGFBR2 BMPR2 HEG1 USHBP1 DOCK6 SEC14L1	3.18e-07	199	146	8	bff61a784ef8bc040f5c7baabccaf7a7cddd5a31
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NES TGFBR2 BMPR2 HEG1 CCM2L USHBP1 DOCK6 SEC14L1	3.18e-07	199	146	8	8b62d43af8b2ebb4c1b2d068d50beaf35728dbe7
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NES TGFBR2 BMPR2 HEG1 CCM2L USHBP1 DOCK6 SEC14L1	3.18e-07	199	146	8	da5a88749d859d535daa030d0974485906cc0ba7
ToppCell	343B-Endothelial_cells-Endothelial-E\|343B / Donor, Lineage, Cell class and subclass (all cells)	NES PRX TGFBR2 BMPR2 HEG1 USHBP1 DOCK6 SEC14L1	3.18e-07	199	146	8	3cb1d9d9de64ed0a56c4f8d5e2fa02a13a73d8ac
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	CACNA1B FAT3 ZFPM2 GREB1L CNTN5 PCDH15 EPHA5	9.69e-07	159	146	7	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	control-Epithelial-Ionocyte\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	BNC2 FAT3 PPP1R12B RET USHBP1 DOCK6 EPHA5	1.24e-06	165	146	7	5cfba9a46bd8ceeca74a6493057b4d38af6b06fe
ToppCell	NS-control-d_0-4-Epithelial-Ionocyte\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	BNC2 FAT3 PPP1R12B RET USHBP1 DOCK6 EPHA5	1.29e-06	166	146	7	6d9fb239f69ba519844f593c00d515e1aac4ff50
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-Mesothelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	BNC2 MAP1B MUC16 ZFPM2 GALNT9 SERPING1 C3	1.98e-06	177	146	7	0912a291cff32a4ff8a2d7680ed1a1cd867fb90f
ToppCell	390C-Endothelial_cells-Endothelial-E-\|390C / Donor, Lineage, Cell class and subclass (all cells)	NES ZGRF1 MYO18A PRX BMPR2 USHBP1 DOCK6	2.06e-06	178	146	7	804ac3725c1f88e2212172bfb9aa01d97a735621
ToppCell	390C-Endothelial_cells-Endothelial-E\|390C / Donor, Lineage, Cell class and subclass (all cells)	NES ZGRF1 MYO18A PRX BMPR2 USHBP1 DOCK6	2.06e-06	178	146	7	ad6dc4a375664c919bd48c35c48a561fc5a7de8c
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NES AFF3 PRX TGFBR2 BMPR2 P2RX7 USHBP1	2.22e-06	180	146	7	544fb373a3346186ec60afe2cfcf141bb04a1eed
ToppCell	COVID-19-Endothelial_cells-Capillary_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	NES AFF3 ITPRID1 PRX BMPR2 DOCK6 SEC14L1	2.30e-06	181	146	7	c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo-stroma-chondrocyte\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ZBTB8B SIX4 TIAM2 GLI2 EPHA5 PDZD2 HR	2.96e-06	188	146	7	c9270517e6940e9793586f67f02431210552f278
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAP1B PPP1R12B AFF3 ZFPM2 MYO3A GLI2 LTBP1	3.06e-06	189	146	7	127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAP1B PPP1R12B AFF3 ZFPM2 MYO3A GLI2 LTBP1	3.06e-06	189	146	7	2cfb4d12f75678d1619f4743838a0e954bd57761
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NES AFF3 PRX ZFPM2 BMPR2 DOCK6 SEC14L1	3.17e-06	190	146	7	0e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP1B BCLAF1 BMPR2 CEP112 SERPING1 C3 LTBP1	3.28e-06	191	146	7	7d1595e616f6f111fc2f5bc1b179c5d67d624cc9
ToppCell	3'_v3-blood-Lymphocytic_NK-Cycling_NK\|blood / Manually curated celltypes from each tissue	ZGRF1 ZWINT CDC7 BRCA1 DHFR ESPL1 TRPV5	3.64e-06	194	146	7	bf9734abaad603ade2a6a6940918aaf1e1c4e2cd
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ZGRF1 RTTN MCM6 ZWINT CDC7 BRCA1 DHFR	3.76e-06	195	146	7	cec7df321f372d05c94f97d6bb18891a5cc3dec3
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ZGRF1 RTTN MCM6 ZWINT CDC7 BRCA1 DHFR	3.89e-06	196	146	7	df366d76ea55f49e349d622effa57c1535df8400
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BNC2 ATG16L1 CTC1 SPEF2 RTTN DGKA DTHD1	4.02e-06	197	146	7	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NES BMPR2 HEG1 CCM2L USHBP1 PTPRR LTBP1	4.16e-06	198	146	7	55378e15360f867c9500b03293814965562ae55d
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn-35\|World / Primary Cells by Cluster	MAP1B BAZ2B BCLAF1 TIAM2 ZNF462 BMPR2 EPHA5	4.16e-06	198	146	7	de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCell	(6)_Endothelial-E\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	NES TGFBR2 BMPR2 HEG1 CCM2L USHBP1 DOCK6	4.16e-06	198	146	7	a5e1b321376caf262ea48904d31afd1b8e9d3be2
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ZGRF1 MCM6 ZWINT CDC7 BRCA1 DHFR ESPL1	4.30e-06	199	146	7	11c3d9fe811a4619347f47d2b0e94066e3085625
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZGRF1 MCM6 ZWINT CDC7 BRCA1 DHFR ESPL1	4.30e-06	199	146	7	36c80907b2ec1cbcd1b4e841e6c02a4792591d74
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	ZGRF1 MCM6 ZWINT CDC7 BRCA1 DHFR ESPL1	4.30e-06	199	146	7	bf4c31902ae8358215245a2e11b5a2fe4ca1bc8c
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZGRF1 MCM6 ZWINT CDC7 BRCA1 DHFR ESPL1	4.30e-06	199	146	7	7beb0e07a27fea94674f24eb61c381b0de38ed3e
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	TRIO VWA8 BAZ2B PPP1R12B AFF3 KMT2C NCOA1	4.30e-06	199	146	7	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Parenchyma_COVID-19-Endothelial-TX-Artery\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	NES BMPR2 HEG1 CCM2L USHBP1 PTPRR LTBP1	4.44e-06	200	146	7	34b279804475ea58fbb052b96f44128c082627a9
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	NES AFF3 PRX TGFBR2 BMPR2 HEG1 USHBP1	4.44e-06	200	146	7	bcd1cc96197929d6011903803b6f4ccdcf52b4ce
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Artery\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	NES BMPR2 HEG1 CCM2L USHBP1 PTPRR LTBP1	4.44e-06	200	146	7	8552cc7a439449b30b59760c3e8667217b9852b5
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PRX TGFBR2 BMPR2 OPTN HEG1 USHBP1 SERPING1	4.44e-06	200	146	7	89821a264e872ed53e08e9d3609d5cc5c314503e
ToppCell	Control_saline-Endothelial-Endothelial-Gen_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	BAZ2B SPEF2 BMPR2 HEG1 USHBP1 DOCK6 SEC14L1	4.44e-06	200	146	7	3b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCell	Control_saline-Endothelial-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	PRX TGFBR2 BMPR2 HEG1 USHBP1 DOCK6 SEC14L1	4.44e-06	200	146	7	e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NES TGFBR2 BMPR2 HEG1 CCM2L USHBP1 SEC14L1	4.44e-06	200	146	7	dba96cda5f3b780a3d4171b61bc8aaddc1f5d466
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	NES AFF3 PRX TGFBR2 BMPR2 HEG1 USHBP1	4.44e-06	200	146	7	b7533c571eeea0cb3678e1a57d3dc036fa8d0f49
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PRX TGFBR2 BMPR2 HEG1 USHBP1 DOCK6 SEC14L1	4.44e-06	200	146	7	a1fa6bae5a688faf488d6925cd3fad725dfa916b
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NES TGFBR2 BMPR2 HEG1 CCM2L USHBP1 DOCK6	4.44e-06	200	146	7	2e47888e041ec3d265425d1df97b6665c6da889c
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	BAZ2B SPEF2 BMPR2 HEG1 USHBP1 DOCK6 SEC14L1	4.44e-06	200	146	7	a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell	LPS_anti-TNF-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PRX TGFBR2 BMPR2 HEG1 USHBP1 DOCK6 SEC14L1	4.44e-06	200	146	7	1d105eeda5a2c51f9a4654ffc79b7e2348ad593b
ToppCell	LPS_IL1RA_TNF-Endothelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PRX TGFBR2 BMPR2 HEG1 USHBP1 DOCK6 SEC14L1	4.44e-06	200	146	7	d01cec331be3b03cef80e9536fc531285bcf00f6
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	BAZ2B SPEF2 BMPR2 HEG1 USHBP1 DOCK6 SEC14L1	4.44e-06	200	146	7	b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NES TGFBR2 BMPR2 HEG1 CCM2L USHBP1 DOCK6	4.44e-06	200	146	7	50fa0f8a3e490d5941b34e66a10158eba6c909d4
ToppCell	LPS_anti-TNF-Endothelial-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PRX TGFBR2 BMPR2 HEG1 USHBP1 DOCK6 SEC14L1	4.44e-06	200	146	7	60d2cbf41f37f1b11eddb4c9d9246c9c1fc5a5af
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	NES AFF3 PRX TGFBR2 BMPR2 HEG1 USHBP1	4.44e-06	200	146	7	432384faeade8e609154fab3d96c955a8ec868dd
ToppCell	Control_saline-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	PRX TGFBR2 BMPR2 HEG1 USHBP1 DOCK6 SEC14L1	4.44e-06	200	146	7	3372c488a39fe812fa94e4f0564594186fea3db5
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NES PRX TGFBR2 BMPR2 HEG1 DOCK6 SEC14L1	4.44e-06	200	146	7	ced14d83222dbebca85c40540e76824e683354f3
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NES TGFBR2 BMPR2 HEG1 CCM2L USHBP1 SEC14L1	4.44e-06	200	146	7	7a69ad5b6c84f1aebacea5cacb9bc5c63dfd1dac
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Artery-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NES BMPR2 HEG1 CCM2L USHBP1 PTPRR LTBP1	4.44e-06	200	146	7	45c08f1befe78553bbadcc2fcffb6138306638f3
ToppCell	390C-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ZGRF1 SPEF2 MYO18A IGFLR1 PRX CYTH4	1.59e-05	162	146	6	45be019b50e3727fc9d3fad2ff78e74e4f2d746b
ToppCell	390C-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ZGRF1 SPEF2 MYO18A IGFLR1 PRX CYTH4	1.59e-05	162	146	6	fbb0cc2b1434a340dc35058b77c73ea61004c252
ToppCell	COVID-19-lung-Mesothelial\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MUC16 GLI2 GALNT9 KNDC1 IGSF9 C3	1.70e-05	164	146	6	83303e2ba52008391b8dc3fae8225ab5bcb20063
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF2 PRX P2RX7 GLI1 GLI2 CYTH4	1.89e-05	167	146	6	f5bffa77061baec0ba87bd688a047595f32534db
ToppCell	control-Epithelial-Ionocyte\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	BNC2 FAT3 PPP1R12B RET USHBP1 EPHA5	1.95e-05	168	146	6	327b02f19f4a8607c033203824fdc60a1254331f
ToppCell	Mild/Remission-B_naive-4\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	LARGE2 RHBDF1 AFF3 ZNF318 TGFBR2 APPL1	2.02e-05	169	146	6	c3a6179a64589a370108fea809b157839347759c
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-neurons_A\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1B MAP1B KIF1B RET PCDH15 EPHA5	2.54e-05	176	146	6	116741fef5895ca85057d2d31eca9eba5764ab44
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-neurons_A-Branch_A1_(iMN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1B MAP1B KIF1B RET PCDH15 EPHA5	2.54e-05	176	146	6	5b707f58d164ee7a6a527dd5d053472ce9a631c1
ToppCell	NS-moderate-d_07-13-Epithelial-Ionocyte\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	BNC2 FAT3 PPP1R12B RET SLC29A2 USHBP1	2.62e-05	177	146	6	99500aed584f793aaf308f8afbf5d1c6a9b4ee55
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BNC2 MUC16 SYNGAP1 C3 LTBP1 HR	2.70e-05	178	146	6	c77a1d1a9aef0ab51b4408b9e84f201219788ca2
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FPR1 MCM6 ZWINT BRCA1 DHFR CKAP4	2.79e-05	179	146	6	e1bfd553c043ebc070ccf8545d489ba16d9b2ef4
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZGRF1 MCM6 ZWINT MYO3A BRCA1 TRPV5	2.79e-05	179	146	6	80112c686a8f85ad5e3cda6e3f3d3d51cf688092
ToppCell	NS-moderate-d_16-33-Epithelial-Ionocyte\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	BNC2 FAT3 PPP1R12B RET USHBP1 EPHA5	2.88e-05	180	146	6	8af8b4af2dc72223ac71fc027e0d4280c5dd81f8
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SELENOH CDC7 NEK3 BRCA1 GBP5 ESPL1	2.88e-05	180	146	6	5e1680088065be14447d5d5465f91f7edd071a1e
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-mesothelial_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MAP1B MUC16 GALNT9 KNDC1 SERPING1 C3	2.97e-05	181	146	6	65eaa9bc1022bcf0c5f0f92c07a2cbbf11f9b59c
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(PRG4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MAP1B MUC16 GALNT9 KNDC1 SERPING1 C3	2.97e-05	181	146	6	eaac7d58117eddfff06b25521efc431c1351d592
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	AFF3 ITPRID1 PRX ZFPM2 BMPR2 SEC14L1	3.06e-05	182	146	6	a20017b6a4f9a6a29e090e4dbd7c02ed1495bd50
ToppCell	Basal\|World / shred by cell class for mouse tongue	LARGE2 MAP1B AFF3 TGFBR2 HEG1 LTBP1	3.16e-05	183	146	6	c6729a207526ff4aa48176207b9353176f631fea
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 FAT3 ZFPM2 GLI1 GLI2 LTBP1	3.16e-05	183	146	6	7eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-cycling_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NES ZWINT TGFBR2 CCM2L BRCA1 DHFR	3.25e-05	184	146	6	fa38d6a8709f520a027ad7e3ff783c84187ec467
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZSWIM2 TTC34 TTLL6 C3 DTHD1 TJP3	3.25e-05	184	146	6	264e14aa1859cfc0ed5fb40e97ea189aed9ef4a5
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZSWIM2 TTC34 TTLL6 C3 DTHD1 TJP3	3.25e-05	184	146	6	d7eccbd21c480d907fdc8eff2bf5ae22ae452221
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZSWIM2 TTC34 TTLL6 C3 DTHD1 TJP3	3.25e-05	184	146	6	22010cfe0428ebfa40952cc1a1a12ad3d25b35c9
ToppCell	tumor_Lung-Fibroblasts-Mesothelial_cells\|tumor_Lung / Location, Cell class and cell subclass	BNC2 ZFPM2 HEG1 GALNT9 SERPING1 C3	3.25e-05	184	146	6	b0a251030d127858e68cf164be158f209a4d720f
ToppCell	COPD-Epithelial-Mesothelial\|World / Disease state, Lineage and Cell class	MAP1B MUC16 ZFPM2 HEG1 GALNT9 C3	3.35e-05	185	146	6	23579988036fc1925992c31919750f9b3fe9f790
ToppCell	3'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NES BMPR2 HEG1 CCM2L USHBP1 PDZD2	3.35e-05	185	146	6	fa94c4a1660967f211ba095606cd0aa37d38e17a
ToppCell	COVID-19-Epithelial_cells-Airway_ciliated\|COVID-19 / group, cell type (main and fine annotations)	NPHP1 C1orf87 SPEF2 MUC16 TTC34 DTHD1	3.35e-05	185	146	6	18a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCell	3'-Adult-Appendix-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NES BMPR2 HEG1 CCM2L USHBP1 PDZD2	3.56e-05	187	146	6	37d8ee5c8bd6324749e5a2adef1d0482c75da80c
ToppCell	3'-Adult-Appendix-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NES BMPR2 HEG1 CCM2L USHBP1 PDZD2	3.56e-05	187	146	6	ec98d5e480b08854dfd0ba6b1dc6610455f90640
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAP1B PPP1R12B AFF3 ZFPM2 GLI2 LTBP1	3.67e-05	188	146	6	b2d68a32314e9b099ed74d974079ad96359d1ae3
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)-D122\|Adult / Lineage, Cell type, age group and donor	NES AFF3 PRX CCM2L DOCK6 SEC14L1	3.67e-05	188	146	6	02a62888e9db29d20133eeca1686d302545a39c9
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ABAT TRIO ARFGEF2 GLI1 PLAGL2 LTBP1	3.67e-05	188	146	6	14bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCell	COPD-Epithelial-Mesothelial\|Epithelial / Disease state, Lineage and Cell class	BNC2 ZFPM2 HEG1 GALNT9 SERPING1 C3	3.67e-05	188	146	6	159d63ecc3653a7449fc6acefd6ef0464845260e
ToppCell	COPD-Epithelial-Mesothelial\|COPD / Disease state, Lineage and Cell class	MAP1B MUC16 ZFPM2 HEG1 GALNT9 C3	3.78e-05	189	146	6	79bb2593ad5d17f94b17972884241f03a0f43770
ToppCell	ASK428-Epithelial-Transformed_epithelium\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	BNC2 EVC2 ZFPM2 HEG1 SERPING1 C3	3.78e-05	189	146	6	87189275234b5d59484c58acbb14a09903f2b578
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LARGE2 BNC2 CEP112 GLI2 PKP1 HR	3.78e-05	189	146	6	6f0fc5271a7d3682f145e734abc3be6473dda2e2
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SPEF2 AFF3 PRX P2RX7 USHBP1 DOCK6	3.78e-05	189	146	6	e82211b9dc7540e7a183be2cbcfae39fdf503949
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LARGE2 BNC2 CEP112 GLI2 PKP1 HR	3.78e-05	189	146	6	3b9ce8964b16cb2200d30cbb0bfc711dcad2380e
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LARGE2 BNC2 CEP112 GLI2 PKP1 HR	3.78e-05	189	146	6	38acb307907fde68b992057714448c1561d69ee3
Drug	3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Up 200; 13.8uM; PC3; HT_HG-U133A	TRIO RET GREB1L SPTBN5 RIF1 AP2B1 PTPRR CLBA1 TJP3	4.85e-06	195	146	9	4298_UP
Drug	Rimexolone [49697-38-3]; Down 200; 10.8uM; MCF7; HT_HG-U133A	NES TNPO2 AP2B1 MTM1 APPL1 LTBP1 DOCK6 TJP3 MPI	5.72e-06	199	146	9	5517_DN
Disease	Colorectal Carcinoma	EVC2 MAP1B ZBTB8B RET ITPRID1 ZNF804A TGFBR2 KMT2C OSBP P2RX7 CCDC62 DHFR HR	4.25e-05	702	144	13	C0009402
Disease	Intellectual Disability	CACNA1B MAP1B TRIO RTTN AFF3 SYNGAP1 ZNF462 KMT2C BRCA1 AP1B1	7.27e-05	447	144	10	C3714756
Disease	Ellis-Van Creveld Syndrome	EVC2 GLI1	1.41e-04	4	144	2	C0013903
Disease	vascular endothelial growth factor measurement	EVC2 VWA8 ZFPM2 ZNF462	1.64e-04	56	144	4	EFO_0004762
Disease	Congenital absence of kidneys syndrome	RET GREB1L	2.34e-04	5	144	2	C1609433
Disease	Malignant neoplasm of breast	C1orf87 PPP1R12B ARFGEF2 ZNF318 SIX4 SIM1 RIF1 BMPR2 BRCA1 GLI1 DHFR NCOA1 APPL1 HERC2 RMND1	2.54e-04	1074	144	15	C0006142
Disease	periventricular nodular heterotopia (is_implicated_in)	MAP1B ARFGEF2	3.50e-04	6	144	2	DOID:0050454 (is_implicated_in)
Disease	lysosomal protective protein measurement	GNPTAB ZFPM2	4.89e-04	7	144	2	EFO_0008215
Disease	acute myocardial infarction (is_marker_for)	SERPING1 C3	4.89e-04	7	144	2	DOID:9408 (is_marker_for)
Disease	Periventricular Nodular Heterotopia	MAP1B ARFGEF2	4.89e-04	7	144	2	C1868720
Disease	Unilateral agenesis of kidney	RET GREB1L	6.50e-04	8	144	2	C0266294
Disease	Dickkopf-related protein 4 measurement	ZFPM2 CEP112	6.50e-04	8	144	2	EFO_0008110
Disease	primary bacterial infectious disease (implicated_via_orthology)	GLI1 GLI2	8.33e-04	9	144	2	DOID:0050338 (implicated_via_orthology)
Disease	lifestyle measurement	AFF3 ARFGEF2 SIM1 CHORDC1 ZNF804A PCDH15	1.07e-03	235	144	6	EFO_0010724
Disease	Squamous cell carcinoma of esophagus	FAT3 PSME2 TGFBR2 KMT2C	1.23e-03	95	144	4	C0279626
Disease	autosomal dominant nonsyndromic deafness (is_implicated_in)	MAP1B GREB1L	1.26e-03	11	144	2	DOID:0050564 (is_implicated_in)
Disease	nucleus accumbens volume change measurement	MUC16 ITPRID1	1.26e-03	11	144	2	EFO_0021493
Disease	mean platelet volume	LDLRAP1 PCDHGA3 KIF1B RTTN AFF3 ZFPM2 AP1B1 AP2B1 CCDC62 GALNT9 SERPING1 LTBP1 ESPL1	1.51e-03	1020	144	13	EFO_0004584
Disease	Gastrointestinal Stromal Sarcoma	TGFBR2 GLI1 GLI2	1.58e-03	47	144	3	C3179349
Disease	Leukemia, Myelocytic, Acute	TRIO CTC1 TSC2 KMT2C BRCA1	1.63e-03	173	144	5	C0023467
Disease	amyotrophic lateral sclerosis (biomarker_via_orthology)	KIF1B C3	1.78e-03	13	144	2	DOID:332 (biomarker_via_orthology)
Disease	immature platelet count	LDLRAP1 RTTN ZFPM2 AP2B1	1.84e-03	106	144	4	EFO_0803544
Disease	Gastrointestinal Stromal Tumors	TGFBR2 GLI1 GLI2	1.89e-03	50	144	3	C0238198
Disease	actinic keratosis	BNC2 HERC2	2.07e-03	14	144	2	EFO_0002496
Disease	Ciliopathies	NPHP1 EVC2 TSC2 PCDH15	2.10e-03	110	144	4	C4277690
Disease	wellbeing measurement	BNC2 BAZ2B ARFGEF2 SIM1 ZNF804A TGFBR2 PTPRR CEP112 CNTN5 RP1L1	2.18e-03	692	144	10	EFO_0007869
Disease	immature platelet fraction	LDLRAP1 KIF1B RTTN ZFPM2	2.40e-03	114	144	4	EFO_0009187
Disease	Drug habituation	AFF3 ZNF804A TIAM2 PCDH15	2.47e-03	115	144	4	C0013170
Disease	Drug abuse	AFF3 ZNF804A TIAM2 PCDH15	2.47e-03	115	144	4	C0013146
Disease	Prescription Drug Abuse	AFF3 ZNF804A TIAM2 PCDH15	2.47e-03	115	144	4	C4316881
Disease	Substance-Related Disorders	AFF3 ZNF804A TIAM2 PCDH15	2.47e-03	115	144	4	C0236969
Disease	Drug Use Disorders	AFF3 ZNF804A TIAM2 PCDH15	2.47e-03	115	144	4	C0013222
Disease	Drug Dependence	AFF3 ZNF804A TIAM2 PCDH15	2.47e-03	115	144	4	C1510472
Disease	Substance Dependence	AFF3 ZNF804A TIAM2 PCDH15	2.47e-03	115	144	4	C0038580
Disease	Substance Use Disorders	AFF3 ZNF804A TIAM2 PCDH15	2.47e-03	115	144	4	C0038586
Disease	Organic Mental Disorders, Substance-Induced	AFF3 ZNF804A TIAM2 PCDH15	2.47e-03	115	144	4	C0029231
Disease	factor VII measurement	FAM83C OPTN CNTN5	2.48e-03	55	144	3	EFO_0004619
Disease	Substance abuse problem	AFF3 ZNF804A TIAM2 PCDH15	2.55e-03	116	144	4	C0740858
Disease	Pheochromocytoma, Extra-Adrenal	KIF1B RET	2.71e-03	16	144	2	C1257877
Disease	immature platelet measurement	LDLRAP1 RTTN ZFPM2 AP2B1	2.80e-03	119	144	4	EFO_0803541
Disease	ocular hypertension (biomarker_via_orthology)	GLI1 C3	3.07e-03	17	144	2	DOID:9282 (biomarker_via_orthology)
Disease	S-adenosylhomocysteine measurement	CACNA1B VWA8	3.07e-03	17	144	2	EFO_0010531
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	KMT2B TRIO	3.07e-03	17	144	2	DOID:0060307 (is_implicated_in)
Disease	primary ciliary dyskinesia (implicated_via_orthology)	SPEF2 AP1B1	3.83e-03	19	144	2	DOID:9562 (implicated_via_orthology)
Disease	Pheochromocytoma	KIF1B RET	3.83e-03	19	144	2	C0031511
Disease	retinal vasculature measurement	LARGE2 TRIO CTC1 AFF3 MCM6 CEP112 HERC2 PDZD2	3.98e-03	517	144	8	EFO_0010554
Disease	Global developmental delay	CACNA1B ABAT ZNF462 AP1B1	4.17e-03	133	144	4	C0557874
Disease	Mammary Neoplasms	PPP1R12B SIM1 TGFBR2 BMPR2 BRCA1 DHFR NCOA1 RMND1	4.46e-03	527	144	8	C1458155
Disease	COVID-19 (is_implicated_in)	SERPING1 C3	4.67e-03	21	144	2	DOID:0080600 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
DPEKLAQELAASLTR	USHBP1	586	Q8N6Y0
NELLSPLKDSDEIRS	AFF3	751	P51826
VLSLATQDSDNPDLR	AP2B1	506	P63010
KSLPESSLTDLLSDN	CTC1	876	Q2NKJ3
DDFSPTSKLQRLLAE	CCDC62	626	Q6P9F0
PQDFLDRLSSLDNLK	CKAP4	526	Q07065
LDSSQPSLSKDLRDE	BNC2	901	Q6ZN30
ITALDLNPERTELLS	ATG16L1	491	Q676U5
SDNPLDIAVTRLADL	BAZ2B	1866	Q9UIF8
RTLLASPSNEVNLLD	EPHA5	51	P54756
DLDRQSLSSIDKNPS	ARFGEF2	1506	Q9Y6D5
PASLRQELEDTISSL	CEP112	916	Q8N8E3
ELNLDVSLQLPSRSS	C3	1291	P01024
VLSLATQDSDNPDLR	AP1B1	506	Q10567
REKQAPELSLSSQDL	DFFA	246	O00273
LPEDQLRNLFDSIKS	CYTH4	226	Q9UIA0
RTLLQAALSTDPLDA	ANKRD52	771	Q8NB46
SSLNPSSRDELLQLL	CCM2L	76	Q9NUG4
ALSSIALAAEDPVRT	CACNA1B	1161	Q00975
RASSDLLSDLPTGKN	C1orf87	386	Q8N0U7
LPDGSLRILNASKSD	CNTN5	531	O94779
RELLSLPATSLADQD	LARGE2	281	Q8N3Y3
DPRPELQATADLLSS	KASH5	151	Q8N6L0
NLLDLEETAKAPLST	LDLRAP1	211	Q5SW96
PAELLEALNTLSEAK	ANKRD31	286	Q8N7Z5
SLTDVSLALSELRPN	BCAN	116	Q96GW7
TSDILDARKTNELPS	MUC16	2351	Q8WXI7
EDINQESAPKASLRL	MCM6	701	Q14566
RLSVELDTAPTLDLN	KRT40	241	Q6A162
QLTDRSEISLLPSDI	GPD2	611	P43304
LLANEKSDNSDIRPS	KMT2C	2921	Q8NEZ4
ALNRDLSTPGLEKDS	MAP1B	1846	P46821
SLLPKDAQLSLNTLD	GNPTAB	701	Q3T906
SSLLSDVSILPNRAE	ITPRID1	216	Q6ZRS4
QESLDALRALPEASL	HERC2	226	O95714
AQLSDRISLDRSIPD	GALNT9	121	Q9HCQ5
AVSDPSILDSLDLNE	EIF2S1	156	P05198
ERLGDSIPKSLSDSL	KIF1B	1516	O60333
TNLAALSLDSLVAPD	APPL1	436	Q9UKG1
SFDTPDDSIRNKLIL	ABAT	441	P80404
DSLQPATDLLTRSEL	ZFPM2	406	Q8WW38
SANISLEFDLELRPS	BPIFA3	116	Q9BQP9
ALPSDDRITNILDSI	HR	786	O43593
TPLNTALNLEKDSDL	LTBP1	1706	Q14766
SLASQLKSEELNLPE	MYO18A	361	Q92614
SAEDLLRLTSKSLPD	PDZD2	421	O15018
LEARNSSEKLPTELS	COIL	266	P38432
DDLNLSTSEALRIDP	DGKA	356	P23743
SLTALEKENQEPLRS	NES	666	P48681
SQPQLLALLDSATER	EVC2	1151	Q86UK5
PIRLTADLSAETLQA	L1RE1	246	Q9UN81
ALPALSRTTELQDEL	MTFR1L	121	Q9H019
TELTDLLKARNSPDL	GBP5	146	Q96PP8
RALSISPLSDASLDL	GLI1	81	P08151
SPLSDASLDLQTVIR	GLI1	86	P08151
RALSISPLSDASLDL	GLI2	231	P10070
LPLRDRQDLATEDTS	KMT2B	896	Q9UMN6
APENLTLLAETADAR	HEG1	156	Q9ULI3
TLLQSLAIEDSRDKP	HECTD4	1141	Q9Y4D8
ELLIDLERPQSNSSA	GREB1L	1111	Q9C091
EVARLLASSDPLAQI	MPI	26	P34949
QRSLSELESLKLPAE	OSBP	236	P22059
TPDTLLNILKNADLS	NEK3	411	P51956
ISDALPSEEVLRSLN	PTPRR	176	Q15256
RDLKLLVTASDSGNP	PCDHGA3	526	Q9Y5H0
DQEATSPRLSRELLD	NBPF3	396	Q9H094
DSLNLTSPLRIVALD	PCDH15	416	Q96QU1
EPLLALDVDSTNSRL	P2RX7	531	Q99572
SIISDSSALEDLRNP	BRCA1	1431	P38398
TLLSSQKEAEELLPA	ESPL1	11	Q14674
AVDAAEALALSSPLR	IGF2-AS	96	Q6U949
NLAADSLLPSLLERA	DOCK6	196	Q96HP0
LDKLLDLNPASRITA	CDC7	546	O00311
DLNPASRITAEEALL	CDC7	551	O00311
LSPSQADSQLDLLSR	FAM83C	546	Q9BQN1
LDDSNRPASLTKDRL	BCLAF1	556	Q9NYF8
SRSLDDALKLTEQPE	DHFR	91	P00374
RDSDSLLSLRPLNID	CRYBB3	96	P26998
LDNSPLVIRATDADS	FAT3	1791	Q8TDW7
ELSSLASQPLSRLLD	IGFLR1	241	Q9H665
KQADSDIPLDRLTIS	MRPL58	66	Q14197
AAASEPSLDLDNLKL	BMPR2	191	Q13873
LELDSLRSQPDASKE	CCDC183	126	Q5T5S1
EENAESLSSTLPLRR	DTHD1	691	Q6ZMT9
LKELSLQASLARPEA	BTBD7	111	Q9P203
NNKISRLLDSLPSDT	SERPING1	271	P05155
TLEPRLSQDLEALLS	KNDC1	141	Q76NI1
LALPQSDASLLSRDE	HEATR1	11	Q9H583
ASSLPRVDDVLASLQ	SEC14L1	646	Q92503
SLLSESQLKEALEPN	NPHP1	26	O15259
RLNLSSNELKSLPAE	LRRC40	201	Q9H9A6
ALERKNSAIPSELNE	OPTN	336	Q96CV9
ASPKAAEAARLLLSD	PKP1	696	Q13835
LDNLLTIAPRDTAKA	RTTN	1621	Q86VV8
TELPARSIDLSALNL	HHLA1	66	C9JL84
QDLLLGPSESNDRLS	SH2B1	421	Q9NRF2
LDSKDNSESQLRIPL	SPEF2	1196	Q9C093
SAVRDEDPLELANTL	TATDN1	271	Q6P1N9
SSPQKVALTLDLDLE	SLC29A2	251	Q14542
DQPLSLTLAALRENT	TATDN2	741	Q93075
QKLRELDPSLVSAND	RIF1	2146	Q5UIP0
DEKDLRSTPNLSLDD	NCOA1	756	Q15788
LPASLERALTEDSTQ	FPR1	316	P21462
SDIAPNDTTRDLILL	GUCY1B2	311	O75343
LRELDLPSQDNVSLT	RHBDF1	121	Q96CC6
LTDTASPQLLDPADR	SIM1	411	P81133
TLLNPTELNRDIADS	SIX4	626	Q9UIU6
SLRLDPTLSVDDLAN	TGFBR2	401	P37173
IRQSLDLFLPDKTAS	RMND1	46	Q9NWS8
LDLAVPETARLDSSL	SAMD14	16	Q8IZD0
SLNVADLTSLRAPLD	PSME2	51	Q9UL46
LLDELIKPTSLASDN	PIAS1	146	O75925
LDEALLAKSPANLSE	PLAGL2	391	Q9UPG8
SISDLSLQLKNRDPE	SPTBN5	2316	Q9NRC6
PLSDLQEEAASASLR	CLBA1	11	Q96F83
LPELSRVEANSTLLN	CHORDC1	251	Q9UHD1
DLLPEAASLSENLDI	UHRF1BP1L	1051	A0JNW5
LDPLASEDTSRQKAI	ZWINT	76	O95229
NEDLAEVASLPRLES	ZYG11B	176	Q9C0D3
EVASLPRLESLDISN	ZYG11B	181	Q9C0D3
PLSESKNRLLDSESQ	ZDHHC20	326	Q5W0Z9
SDSDLFSRDQKSLLP	TIAM2	986	Q8IVF5
LEELQLANSAKLSDP	MTM1	571	Q13496
LLSPSSAAEALELNL	SYNGAP1	186	Q96PV0
SPALSLSSLRSDDLQ	RP1L1	576	Q8IWN7
ELREDSPAARSLSLQ	PRX	46	Q9BXM0
DSSELLDSDALNRPL	TNPO2	156	O14787
AAALSQALRLEAPEL	SELENOH	51	Q8IZQ5
KDISSALRVNPALAE	RNH1	46	P13489
PERALNSALAEEITL	PPP1R3F	541	Q6ZSY5
DSNSSLILRPLTKEA	IGSF9	466	Q9P2J2
DLRNINLSSSKLEPS	TTLL6	596	Q8N841
KENASPSELRDLLSE	RET	761	P07949
DNKRSTLLPEDFNLI	ZSWIM2	566	Q8NEG5
RDSNAAPLLEILTDQ	ZSWIM8	361	A7E2V4
LEDISDLASELSQAP	TJP3	291	O95049
SLLTNEPVKRDSLAS	ZGRF1	226	Q86YA3
EDARLSPEKSLQLAS	ZNF462	1446	Q96JM2
PSLARSALEKNLADA	VWA8	691	A3KMH1
RDLQSLAEVDAPDLS	TTC34	361	A8MYJ7
KLDSFLSEARSLLNP	ZNF318	1866	Q5VUA4
SDTLEALLLTASERP	UGGT1	161	Q9NYU2
LQPDSQDDKASSRLL	TRIO	1881	O75962
ESPLLRASKENDLSV	TRPV5	46	Q9NQA5
LRSNVLLSFDDTPEK	TSC2	916	P49815
VKDNSSLNPLDRLIS	ZNF804A	836	Q7Z570
IIRSAPATELLDSSN	ZNF628	976	Q5EBL2
LEALLRNSAAPSKDD	ZBTB8B	281	Q8NAP8
ALRSLVLAENSISPE	LRRC73	231	Q5JTD7
LPTDIVLLLRSSDNS	MYO3A	851	Q8NEV4
SLAPRKLNSTSDIEE	PPP1R12B	496	O60237