Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmodification-dependent protein binding

STK38 RRP8 NANOGP1

1.07e-0520653GO:0140030
GeneOntologyMolecularFunctionS-adenosylmethionine-dependent methyltransferase activity

RRP8 KMT2C

7.25e-0417252GO:0008757
GeneOntologyMolecularFunctionmethyltransferase activity

RRP8 KMT2C

1.11e-0321352GO:0008168
GeneOntologyMolecularFunctiontransferase activity, transferring one-carbon groups

RRP8 KMT2C

1.23e-0322452GO:0016741
GeneOntologyMolecularFunctionhistone binding

RRP8 NANOGP1

1.71e-0326552GO:0042393
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

STK38 KMT2C NANOGP1

1.79e-03116053GO:0030674
GeneOntologyMolecularFunctionmolecular adaptor activity

STK38 KMT2C NANOGP1

2.82e-03135653GO:0060090
GeneOntologyBiologicalProcesschromatin organization

STK38 RRP8 KMT2C

7.65e-0489653GO:0006325
GeneOntologyBiologicalProcessprotein-DNA complex organization

STK38 RRP8 KMT2C

1.05e-0399953GO:0071824
GeneOntologyBiologicalProcessmethylation

RRP8 KMT2C

1.25e-0323452GO:0032259
GeneOntologyBiologicalProcessregulation of cell cycle

STK38 RRP8 NANOGP1

2.05e-03125653GO:0051726
GeneOntologyBiologicalProcessnegative regulation of cell cycle

STK38 RRP8

4.83e-0346452GO:0045786
PathwayREACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION

RRP8 KMT2C

3.12e-0325452M27131
Pubmed

MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.

KMT2C NANOGP1

9.09e-07115237012455
Pubmed

Rebalancing gene haploinsufficiency in vivo by targeting chromatin.

KMT2C NANOGP1

6.24e-06285227256596
Pubmed

Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.

KMT2C NANOGP1

1.56e-05445224183668
Pubmed

High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization.

KMT2C NANOGP1

7.19e-05945216325481
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

KMT2C NANOGP1

1.74e-041465223892456
CoexpressionPASINI_SUZ12_TARGETS_UP

KMT2C NANOGP1

2.24e-0412552MM1065
CoexpressionGSE32901_NAIVE_VS_TH17_ENRICHED_CD4_TCELL_UP

STK38 CPA3

3.39e-0415452M8927
CoexpressionGSE13738_RESTING_VS_TCR_ACTIVATED_CD4_TCELL_UP

STK38 KMT2C

5.43e-0419552M3319
CoexpressionGSE9960_GRAM_NEG_VS_GRAM_NEG_AND_POS_SEPSIS_PBMC_DN

RRP8 KMT2C

5.65e-0419952M7131
CoexpressionGSE19888_CTRL_VS_A3R_ACT_TREATED_MAST_CELL_PRETREATED_WITH_A3R_INH_UP

STK38 KMT2C

5.65e-0419952M7329
CoexpressionGSE4748_CTRL_VS_CYANOBACTERIUM_LPSLIKE_STIM_DC_3H_UP

STK38 KMT2C

5.71e-0420052M6477
CoexpressionRAO_BOUND_BY_SALL4

STK38 NANOGP1

8.68e-0424752MM1081
CoexpressionRODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP

STK38 KMT2C

7.15e-0372152M10237
CoexpressionMURARO_PANCREAS_DUCTAL_CELL

STK38 CPA3

2.15e-02127652M39173
CoexpressionPUJANA_ATM_PCC_NETWORK

STK38 RRP8

2.54e-02139452M9585
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

KMT2C CPA3

2.89e-02149252M40023
ToppCellCOVID-19-Mast_cells-Transitioning_MDM|COVID-19 / group, cell type (main and fine annotations)

RRP8 CPA3

1.03e-04145525c5fed4620c4c312d1052b8acad910453f7e8fcc
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

KMT2C CPA3

1.89e-041975257ebd552f10d6278623b52a3d484d4b91ae1d028
DrugAC1NQAN2

STK38 KMT2C

3.15e-061742CID005193003
DrugAC1L9KN8

STK38 KMT2C

6.38e-062442CID000447254
DrugChloramphenicol [56-75-7]; Down 200; 12.4uM; HL60; HT_HG-U133A

STK38 RRP8

4.33e-04195421837_DN

Protein segments in the cluster

PeptideGeneStartEntry
WKFRQQMRQKSKQQA

KMT2C

1751

Q8NEZ4
SWTKNRMWRKNRSKN

CPA3

226

P15088
RMWRKNRSKNQNSKC

CPA3

231

P15088
NMNSKRKAETWKRNR

STK38

261

Q15208
KQWRNRQKNKRRCKN

RRP8

186

O43159
QVKTWFQNQRMKSKR

NANOGP1

81

Q8N7R0
FQNQRMKSKRWQKNN

NANOGP1

86

Q8N7R0