Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	mRNA binding	RBMXL2 SRSF1 RBMXL3 RBMY1A1 SYNCRIP HNRNPR	3.38e-04	694	28	6	GO:0003729
GeneOntologyMolecularFunction	snRNA binding	RBMXL2 RBMXL3	2.89e-03	57	28	2	GO:0017069
GeneOntologyBiologicalProcess	positive regulation of RNA splicing	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 RBMY1A1 RBMY1C RBMY1F	8.41e-17	63	28	9	GO:0033120
GeneOntologyBiologicalProcess	positive regulation of mRNA splicing, via spliceosome	RBMY1D RBMY1B RBMY1E RBMXL2 RBMXL3 RBMY1A1 RBMY1C RBMY1F	6.58e-16	44	28	8	GO:0048026
GeneOntologyBiologicalProcess	positive regulation of mRNA processing	RBMY1D RBMY1B RBMY1E RBMXL2 RBMXL3 RBMY1A1 RBMY1C RBMY1F	1.67e-15	49	28	8	GO:0050685
GeneOntologyBiologicalProcess	mRNA splicing, via spliceosome	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 HNRNPUL2 RBMY1A1 RBMY1C RBMY1F SYNCRIP HNRNPR	1.47e-14	358	28	12	GO:0000398
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 HNRNPUL2 RBMY1A1 RBMY1C RBMY1F SYNCRIP HNRNPR	1.47e-14	358	28	12	GO:0000377
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 HNRNPUL2 RBMY1A1 RBMY1C RBMY1F SYNCRIP HNRNPR	1.68e-14	362	28	12	GO:0000375
GeneOntologyBiologicalProcess	RNA splicing	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 HNRNPUL2 CLK4 RBMY1A1 RBMY1C RBMY1F SYNCRIP HNRNPR	2.42e-14	502	28	13	GO:0008380
GeneOntologyBiologicalProcess	regulation of RNA splicing	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 CLK4 RBMY1A1 RBMY1C RBMY1F	9.34e-14	207	28	10	GO:0043484
GeneOntologyBiologicalProcess	positive regulation of mRNA metabolic process	RBMY1D RBMY1B RBMY1E RBMXL2 RBMXL3 RBMY1A1 RBMY1C RBMY1F SYNCRIP HNRNPR	8.81e-13	259	28	10	GO:1903313
GeneOntologyBiologicalProcess	mRNA processing	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 HNRNPUL2 RBMY1A1 RBMY1C RBMY1F SYNCRIP HNRNPR	2.42e-12	551	28	12	GO:0006397
GeneOntologyBiologicalProcess	regulation of mRNA splicing, via spliceosome	RBMY1D RBMY1B RBMY1E RBMXL2 RBMXL3 RBMY1A1 RBMY1C RBMY1F	5.26e-12	129	28	8	GO:0048024
GeneOntologyBiologicalProcess	regulation of mRNA metabolic process	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 RBMY1A1 RBMY1C RBMY1F SYNCRIP HNRNPR	6.13e-12	443	28	11	GO:1903311
GeneOntologyBiologicalProcess	regulation of mRNA processing	RBMY1D RBMY1B RBMY1E RBMXL2 RBMXL3 RBMY1A1 RBMY1C RBMY1F	2.71e-11	158	28	8	GO:0050684
GeneOntologyBiologicalProcess	mRNA metabolic process	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 HNRNPUL2 RBMY1A1 RBMY1C RBMY1F SYNCRIP HNRNPR	8.74e-10	917	28	12	GO:0016071
GeneOntologyBiologicalProcess	positive regulation of gene expression	RBMY1D RBMY1B RBMY1E SEC16B RHBDD1 ARID1B RBMXL2 SRSF1 RBMXL3 RBMY1A1 RBMY1C RBMY1F SYNCRIP	1.30e-08	1446	28	13	GO:0010628
GeneOntologyBiologicalProcess	RNA processing	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 HNRNPUL2 CLK4 RBMY1A1 RBMY1C RBMY1F SYNCRIP HNRNPR	2.01e-08	1500	28	13	GO:0006396
GeneOntologyBiologicalProcess	male gonad development	RBMY1D RBMY1B RBMY1E RBMY1A1	7.99e-05	171	28	4	GO:0008584
GeneOntologyBiologicalProcess	development of primary male sexual characteristics	RBMY1D RBMY1B RBMY1E RBMY1A1	8.18e-05	172	28	4	GO:0046546
GeneOntologyBiologicalProcess	hematopoietic progenitor cell differentiation	RBMY1D RBMY1B RBMY1E RBMY1A1	1.38e-04	197	28	4	GO:0002244
GeneOntologyBiologicalProcess	male sex differentiation	RBMY1D RBMY1B RBMY1E RBMY1A1	1.44e-04	199	28	4	GO:0046661
GeneOntologyBiologicalProcess	alternative mRNA splicing, via spliceosome	SRSF1 HNRNPUL2 RBMY1A1	1.65e-04	79	28	3	GO:0000380
GeneOntologyBiologicalProcess	gonad development	RBMY1D RBMY1B RBMY1E RBMY1A1	6.16e-04	292	28	4	GO:0008406
GeneOntologyBiologicalProcess	development of primary sexual characteristics	RBMY1D RBMY1B RBMY1E RBMY1A1	6.57e-04	297	28	4	GO:0045137
GeneOntologyBiologicalProcess	hemopoiesis	RBMY1D RBMY1B RBMY1E NEDD9 PSMB11 ARID1B RBMY1A1	9.97e-04	1223	28	7	GO:0030097
GeneOntologyBiologicalProcess	sex differentiation	RBMY1D RBMY1B RBMY1E RBMY1A1	1.23e-03	352	28	4	GO:0007548
GeneOntologyBiologicalProcess	reproductive structure development	RBMY1D RBMY1B RBMY1E RBMY1A1	1.68e-03	383	28	4	GO:0048608
GeneOntologyBiologicalProcess	reproductive system development	RBMY1D RBMY1B RBMY1E RBMY1A1	1.77e-03	388	28	4	GO:0061458
GeneOntologyCellularComponent	spliceosomal complex	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 RBMY1A1 RBMY1C RBMY1F SYNCRIP HNRNPR	1.94e-15	215	28	11	GO:0005681
GeneOntologyCellularComponent	nuclear protein-containing complex	RBMY1D RBMY1B RBMY1E ARID1B RBMXL2 SRSF1 RBMXL3 RBMY1A1 RBMY1C RBMY1F SYNCRIP HNRNPR	7.20e-08	1377	28	12	GO:0140513
GeneOntologyCellularComponent	ribonucleoprotein complex	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 RBMY1A1 RBMY1C RBMY1F SYNCRIP HNRNPR	1.76e-07	1194	28	11	GO:1990904
GeneOntologyCellularComponent	male germ cell nucleus	RBMY1D RBMY1B RBMY1E RBMY1A1	5.07e-06	86	28	4	GO:0001673
GeneOntologyCellularComponent	germ cell nucleus	RBMY1D RBMY1B RBMY1E RBMY1A1	1.50e-05	113	28	4	GO:0043073
GeneOntologyCellularComponent	catalytic step 2 spliceosome	SRSF1 SYNCRIP HNRNPR	2.92e-04	97	28	3	GO:0071013
GeneOntologyCellularComponent	U12-type spliceosomal complex	RBMXL2 RBMXL3	7.35e-04	30	28	2	GO:0005689
HumanPheno	Short distal phalanx of the 5th finger	ARID1B HNRNPR	4.52e-05	7	8	2	HP:0004227
HumanPheno	Aplasia/Hypoplasia of the distal phalanx of the 5th finger	ARID1B HNRNPR	4.52e-05	7	8	2	HP:0009239
Domain	RBM1CTR	RBMY1D RBMY1B RBMY1E RBMXL2 RBMY1A1 RBMY1F	1.09e-16	8	26	6	PF08081
Domain	RBM1CTR	RBMY1D RBMY1B RBMY1E RBMXL2 RBMY1A1 RBMY1F	1.09e-16	8	26	6	IPR012604
Domain	RRM_1	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 RBMY1A1 RBMY1F SYNCRIP HNRNPR	1.07e-13	208	26	10	PF00076
Domain	RRM	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 RBMY1A1 RBMY1F SYNCRIP HNRNPR	1.64e-13	217	26	10	SM00360
Domain	RRM_dom	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 RBMY1A1 RBMY1F SYNCRIP HNRNPR	2.58e-13	227	26	10	IPR000504
Domain	RRM	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 RBMY1A1 RBMY1F SYNCRIP HNRNPR	2.95e-13	230	26	10	PS50102
Domain	Nucleotide-bd_a/b_plait	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 RBMY1A1 RBMY1F SYNCRIP HNRNPR	9.30e-13	258	26	10	IPR012677
Domain	-	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 RBMY1F SYNCRIP HNRNPR	2.46e-11	244	26	9	3.30.70.330
Domain	HnRNP_R/Q_splicing_fac	SYNCRIP HNRNPR	1.86e-05	5	26	2	IPR006535
Pathway	WP_MRNA_PROCESSING	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 CLK4 RBMY1A1 SYNCRIP HNRNPR	2.62e-10	451	21	10	MM15946
Pathway	REACTOME_SENSORY_PROCESSING_OF_SOUND	MYO15A OTOGL PCLO	1.94e-04	77	21	3	M41822
Pubmed	A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis.	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1C RBMY1F	1.07e-18	7	28	6	8269511
Pubmed	Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene.	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1C RBMY1F	1.41e-16	12	28	6	9598316
Pubmed	RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts.	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1F	1.39e-15	6	28	5	15184870
Pubmed	Degeneracy in human multicopy RBM (YRRM), a candidate spermatogenesis gene.	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1F	4.86e-15	7	28	5	8875892
Pubmed	RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing.	RBMY1B RBMXL2 RBMY1A1 RBMY1C RBMY1F	2.97e-13	13	28	5	10749975
Pubmed	Human RBMY regulates germline-specific splicing events by modulating the function of the serine/arginine-rich proteins 9G8 and Tra2-{beta}.	RBMY1D RBMY1B RBMY1E RBMY1A1	1.68e-12	5	28	4	20016065
Pubmed	An RBM homologue maps to the mouse Y chromosome and is expressed in germ cells.	RBMY1D RBMY1B RBMY1E RBMY1A1	1.68e-12	5	28	4	8817321
Pubmed	The role of human and mouse Y chromosome genes in male infertility.	RBMY1D RBMY1B RBMY1E RBMY1A1	1.68e-12	5	28	4	11097427
Pubmed	Rapid evolution of mouse Y centromere repeat DNA belies recent sequence stability.	RBMY1D RBMY1B RBMY1E RBMY1A1	1.68e-12	5	28	4	19737860
Pubmed	Identification of target messenger RNA substrates for mouse RBMY.	RBMY1D RBMY1B RBMY1E RBMY1A1	5.03e-12	6	28	4	18492746
Pubmed	Meiotic sex chromosome inactivation in male mice with targeted disruptions of Xist.	RBMY1D RBMY1B RBMY1E RBMY1A1	5.03e-12	6	28	4	12356914
Pubmed	The behavior of the X- and Y-chromosomes in the oocyte during meiotic prophase in the B6.Y(TIR)sex-reversed mouse ovary.	RBMY1D RBMY1B RBMY1E RBMY1A1	5.03e-12	6	28	4	18239052
Pubmed	Does Rbmy have a role in sperm development in mice?	RBMY1D RBMY1B RBMY1E RBMY1A1	5.03e-12	6	28	4	15051956
Pubmed	Mouse homologues of the human AZF candidate gene RBM are expressed in spermatogonia and spermatids, and map to a Y chromosome deletion interval associated with a high incidence of sperm abnormalities.	RBMY1D RBMY1B RBMY1E RBMY1A1	5.03e-12	6	28	4	9499427
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 RBMY1A1 SYNCRIP HNRNPR	5.16e-12	347	28	9	16033648
Pubmed	RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway.	RBMY1D RBMY1B RBMY1E RBMY1A1	1.17e-11	7	28	4	17001072
Pubmed	The roles of RNA-binding proteins in spermatogenesis and male infertility.	RBMY1D RBMY1B RBMY1E RBMY1A1	1.17e-11	7	28	4	10377282
Pubmed	Y chromosome short arm-Sxr recombination in XSxr/Y males causes deletion of Rbm and XY female sex reversal.	RBMY1D RBMY1B RBMY1E RBMY1A1	2.35e-11	8	28	4	7479793
Pubmed	Mice with Y chromosome deletion and reduced Rbm genes on a heterozygous Dazl1 null background mimic a human azoospermic factor phenotype.	RBMY1D RBMY1B RBMY1E RBMY1A1	7.03e-11	10	28	4	10601091
Pubmed	Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene.	RBMY1D RBMY1B RBMY1E RBMY1A1	7.03e-11	10	28	4	9384609
Pubmed	The role of Dby mRNA in early development of male mouse zygotes.	RBMY1D RBMY1B RBMY1E RBMY1A1	1.66e-10	12	28	4	20543856
Pubmed	GASZ promotes germ cell derivation from embryonic stem cells.	RBMY1D RBMY1B RBMY1E RBMY1A1	2.39e-10	13	28	4	23816659
Pubmed	Absence of mDazl produces a final block on germ cell development at meiosis.	RBMY1D RBMY1B RBMY1E RBMY1A1	3.34e-10	14	28	4	14611631
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	RBMY1D RBMY1B RBMY1E RBMY1A1	4.56e-10	15	28	4	14762062
Pubmed	Loss of maternal Trim28 causes male-predominant early embryonic lethality.	RBMY1D RBMY1B RBMY1E RBMY1A1	7.94e-10	17	28	4	28115466
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	RBMY1D RBMY1B RBMY1E RBMY1A1	1.02e-09	18	28	4	12023983
Pubmed	MRNIP interacts with sex body chromatin to support meiotic progression, spermatogenesis, and male fertility in mice.	RBMY1D RBMY1B RBMY1E RBMY1A1	4.96e-09	26	28	4	35920200
Pubmed	RNF125 attenuates hepatocellular carcinoma progression by downregulating SRSF1-ERK pathway.	SRSF1 SYNCRIP HNRNPR	7.68e-08	11	28	3	37142680
Pubmed	Lineage-specific biology revealed by a finished genome assembly of the mouse.	RBMY1D RBMY1B RBMY1E RBMY1A1	1.11e-07	55	28	4	19468303
Pubmed	An abundance of X-linked genes expressed in spermatogonia.	RBMY1D RBMY1B RBMY1E RBMY1A1	1.48e-07	59	28	4	11279525
Pubmed	Haploinsufficiency of the germ cell-specific nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in the mouse.	RBMXL2 RBMXL3	6.25e-07	2	28	2	18562473
Pubmed	Potential dual functional roles of the Y-linked RBMY in hepatocarcinogenesis.	RBMY1B RBMY1A1	6.25e-07	2	28	2	32473614
Pubmed	An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning.	RBMXL2 RBMXL3	6.25e-07	2	28	2	30674417
Pubmed	Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.	RBMY1D RBMY1B RBMY1E RBMY1A1	1.02e-06	95	28	4	24029230
Pubmed	The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1F	1.32e-06	241	28	5	12815422
Pubmed	Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy.	SRSF1 HNRNPUL2 SYNCRIP HNRNPR	1.76e-06	109	28	4	29511296
Pubmed	The germ cell nuclear proteins hnRNP G-T and RBMY activate a testis-specific exon.	RBMXL2 RBMY1A1	1.87e-06	3	28	2	19893608
Pubmed	Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS.	SYNCRIP HNRNPR	1.87e-06	3	28	2	30755280
Pubmed	SMN interacts with a novel family of hnRNP and spliceosomal proteins.	SYNCRIP HNRNPR	3.75e-06	4	28	2	11574476
Pubmed	Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?	SYNCRIP HNRNPR	3.75e-06	4	28	2	11773003
Pubmed	Functional association of human Ki-1/57 with pre-mRNA splicing events.	SRSF1 SYNCRIP	9.36e-06	6	28	2	19523114
Pubmed	Identification of a heterogeneous nuclear ribonucleoprotein-recognition region in the HIV Rev protein.	SYNCRIP HNRNPR	1.74e-05	8	28	2	19808671
Pubmed	Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy.	SYNCRIP HNRNPR	1.74e-05	8	28	2	12183049
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	ARID1B RBMXL2 SRSF1 RBMXL3 HNRNPUL2 SYNCRIP HNRNPR	2.78e-05	1153	28	7	29845934
Pubmed	T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis.	RBMY1A1 RBMY1C	2.80e-05	10	28	2	10332027
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	ARID1B SRSF1 CDC25C HNRNPUL2 GTF3C5 SYNCRIP HNRNPR	2.81e-05	1155	28	7	20360068
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	ARID1B SRSF1 HNRNPUL2 HNRNPR	2.83e-05	220	28	4	35785414
Pubmed	BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.	RBMXL2 HNRNPUL2 SYNCRIP HNRNPR	3.15e-05	226	28	4	25900982
Pubmed	SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms.	SYNCRIP HNRNPR	3.42e-05	11	28	2	10734137
Pubmed	Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.	SRSF1 SYNCRIP HNRNPR	3.68e-05	80	28	3	11991638
Pubmed	The activity of the spinal muscular atrophy protein is regulated during development and cellular differentiation.	SYNCRIP HNRNPR	4.10e-05	12	28	2	16236758
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	SRSF1 HNRNPUL2 SYNCRIP HNRNPR	4.24e-05	244	28	4	29884807
Pubmed	DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.	SRSF1 SYNCRIP HNRNPR	5.07e-05	89	28	3	22446626
Pubmed	Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6.	HNRNPUL2 SYNCRIP HNRNPR	5.24e-05	90	28	3	23151878
Pubmed	Cullin-3/KCTD10 complex is essential for K27-polyubiquitination of EIF3D in human hepatocellular carcinoma HepG2 cells.	PCLO SYNCRIP HNRNPR	5.24e-05	90	28	3	31280863
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	SRSF1 HNRNPUL2 SYNCRIP HNRNPR	5.27e-05	258	28	4	37794589
Pubmed	Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop.	SRSF1 HNRNPUL2 SYNCRIP HNRNPR	5.43e-05	260	28	4	36199071
Pubmed	Ki-1/57 interacts with PRMT1 and is a substrate for arginine methylation.	SRSF1 SYNCRIP	6.52e-05	15	28	2	16879614
Pubmed	A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons.	SYNCRIP HNRNPR	8.44e-05	17	28	2	12388589
Pubmed	Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.	SRSF1 SYNCRIP HNRNPR	1.09e-04	115	28	3	17332742
Pubmed	Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.	SRSF1 GTF3C5 HNRNPR	1.11e-04	116	28	3	21549307
Pubmed	Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication.	HNRNPUL2 SYNCRIP HNRNPR	1.26e-04	121	28	3	34029587
Pubmed	Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.	SRSF1 SYNCRIP HNRNPR	1.36e-04	124	28	3	23000965
Pubmed	NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.	SRSF1 HNRNPUL2 SYNCRIP HNRNPR	1.41e-04	333	28	4	32665550
Pubmed	ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.	RBMXL2 SRSF1 SYNCRIP HNRNPR	1.46e-04	336	28	4	31253590
Pubmed	Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.	SRSF1 HNRNPUL2 HNRNPR	1.60e-04	131	28	3	34551306
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	SRSF1 HNRNPUL2 GTF3C5 SYNCRIP HNRNPR	1.60e-04	655	28	5	35819319
Pubmed	A COFRADIC protocol to study protein ubiquitination.	SRSF1 SYNCRIP HNRNPR	1.71e-04	134	28	3	24816145
Pubmed	Immunoprecipitation and mass spectrometry defines an extensive RBM45 protein-protein interaction network.	HNRNPUL2 SYNCRIP HNRNPR	1.78e-04	136	28	3	26979993
Pubmed	Interactome analysis of the human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (hMTr1) protein.	SRSF1 SYNCRIP HNRNPR	1.86e-04	138	28	3	30320910
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	ARID1B SRSF1 HNRNPUL2 GTF3C5 SYNCRIP HNRNPR	1.87e-04	1082	28	6	38697112
Pubmed	The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.	HNRNPUL2 SYNCRIP HNRNPR	2.24e-04	147	28	3	28977470
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	SRSF1 HNRNPUL2 GTF3C5 SYNCRIP HNRNPR	2.34e-04	711	28	5	33022573
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	SRSF1 HNRNPUL2 GTF3C5 SYNCRIP HNRNPR	2.37e-04	713	28	5	29802200
Pubmed	Identification of intracellular proteins associated with the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-ICR mass spectrometry.	SRSF1 SYNCRIP HNRNPR	2.43e-04	151	28	3	18457437
Pubmed	Proteomic analysis of the cullin 4B interactome using proximity-dependent biotinylation in living cells.	RBMXL2 RBMXL3 HNRNPR	2.52e-04	153	28	3	28225217
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	SRSF1 HNRNPUL2 GTF3C5 SYNCRIP HNRNPR	2.56e-04	725	28	5	27025967
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	HNRNPUL2 GTF3C5 SYNCRIP HNRNPR	2.58e-04	390	28	4	17643375
Pubmed	Systematic and quantitative assessment of the ubiquitin-modified proteome.	SRSF1 SYNCRIP HNRNPR	2.77e-04	158	28	3	21906983
Pubmed	Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress.	HNRNPUL2 SYNCRIP HNRNPR	2.82e-04	159	28	3	22751105
Pubmed	A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.	SRSF1 SYNCRIP HNRNPR	2.98e-04	162	28	3	21890473
Pubmed	Proteomic analysis of complexes formed by human topoisomerase I.	SRSF1 HNRNPR	3.05e-04	32	28	2	15848144
Pubmed	Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.	HNRNPUL2 SYNCRIP HNRNPR	3.20e-04	166	28	3	27160897
Pubmed	Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.	SRSF1 HNRNPUL2 SYNCRIP HNRNPR	3.44e-04	421	28	4	34650049
Pubmed	Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis.	SRSF1 HNRNPUL2 SYNCRIP	3.56e-04	172	28	3	26336360
Pubmed	RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.	SRSF1 HNRNPUL2 SYNCRIP HNRNPR	3.57e-04	425	28	4	21081503
Pubmed	TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.	SRSF1 HNRNPUL2 SYNCRIP HNRNPR	3.73e-04	430	28	4	38172120
Pubmed	Molecular composition of IMP1 ribonucleoprotein granules.	SYNCRIP HNRNPR	3.87e-04	36	28	2	17289661
Pubmed	Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.	SRSF1 SYNCRIP HNRNPR	4.06e-04	180	28	3	21139048
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	RBMXL2 RBMXL3 HNRNPUL2 SYNCRIP HNRNPR	5.14e-04	844	28	5	25963833
Pubmed	LINKIN, a new transmembrane protein necessary for cell adhesion.	HNRNPUL2 GTF3C5 SYNCRIP HNRNPR	5.64e-04	480	28	4	25437307
Pubmed	Profiling of Parkin-binding partners using tandem affinity purification.	SRSF1 SYNCRIP HNRNPR	5.76e-04	203	28	3	24244333
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	RBMXL2 SRSF1 SYNCRIP HNRNPR	5.91e-04	486	28	4	30940648
Pubmed	Interactomic analysis of REST/NRSF and implications of its functional links with the transcription suppressor TRIM28 during neuronal differentiation.	SRSF1 SYNCRIP HNRNPR	5.93e-04	205	28	3	27976729
Pubmed	Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.	SRSF1 HNRNPUL2 SYNCRIP	6.81e-04	215	28	3	30462309
Pubmed	Identification of DeltaNp63alpha protein interactions by mass spectrometry.	SYNCRIP HNRNPR	6.89e-04	48	28	2	20085233
Pubmed	Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.	HNRNPUL2 SYNCRIP HNRNPR	7.57e-04	223	28	3	20020773
Pubmed	A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells.	SRSF1 CLK4	7.78e-04	51	28	2	34316707
Interaction	PCDHB14 interactions	RBMY1A1 RBMY1F HNRNPR	3.63e-06	22	28	3	int:PCDHB14
Interaction	RBMY1J interactions	RBMY1E RBMY1A1 RBMY1F	8.57e-06	29	28	3	int:RBMY1J
Interaction	RBMY1E interactions	RBMY1E RBMY1F	1.11e-05	4	28	2	int:RBMY1E
Interaction	CLK3 interactions	SRSF1 HNRNPUL2 RBMY1A1 RBMY1F HNRNPR	1.19e-05	220	28	5	int:CLK3
Interaction	RBMY1F interactions	RBMY1E RBMY1A1 RBMY1F	1.66e-05	36	28	3	int:RBMY1F
Interaction	PRR3 interactions	HNRNPUL2 RBMY1A1 RBMY1F SYNCRIP HNRNPR	2.03e-05	246	28	5	int:PRR3
Interaction	RBMX interactions	RBMY1E RBMXL2 SRSF1 RBMY1A1 RBMY1F HNRNPR	3.41e-05	461	28	6	int:RBMX
Interaction	RASD1 interactions	RBMY1A1 RBMY1F HNRNPR	3.50e-05	46	28	3	int:RASD1
Interaction	SNRPA interactions	SRSF1 HNRNPUL2 RBMY1A1 RBMY1F SYNCRIP HNRNPR	4.37e-05	482	28	6	int:SNRPA
Interaction	RNF125 interactions	SRSF1 SYNCRIP HNRNPR	5.37e-05	53	28	3	int:RNF125
Interaction	RBMXL1 interactions	RBMXL2 SRSF1 HNRNPUL2 SYNCRIP	5.97e-05	155	28	4	int:RBMXL1
Interaction	SLC50A1 interactions	SRSF1 CDC25C	6.66e-05	9	28	2	int:SLC50A1
Interaction	ELAVL2 interactions	SRSF1 HNRNPUL2 SYNCRIP HNRNPR	1.26e-04	188	28	4	int:ELAVL2
Interaction	BRD7 interactions	ARID1B RBMXL2 SRSF1 GTF3C5 SYNCRIP HNRNPR	2.03e-04	637	28	6	int:BRD7
Interaction	MCM5 interactions	RBMXL2 RBMXL3 HNRNPUL2 SYNCRIP HNRNPR	2.54e-04	420	28	5	int:MCM5
Interaction	KHDRBS3 interactions	RBMY1A1 SYNCRIP HNRNPR	2.96e-04	94	28	3	int:KHDRBS3
Interaction	C19orf33 interactions	SRSF1 GTF3C5	3.85e-04	21	28	2	int:C19orf33
Interaction	PRMT8 interactions	HNRNPUL2 SYNCRIP HNRNPR	3.98e-04	104	28	3	int:PRMT8
Interaction	CUL4B interactions	CCDC80 RBMXL2 SRSF1 RBMXL3 SYNCRIP HNRNPR	4.15e-04	728	28	6	int:CUL4B
Cytoband	Yq11.223	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1F	2.90e-09	93	28	5	Yq11.223
Cytoband	Ensembl 112 genes in cytogenetic band chrYq11	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1F	1.19e-06	311	28	5	chrYq11
GeneFamily	RNA binding motif containing	RBMY1D RBMY1B RBMY1E RBMXL2 SRSF1 RBMXL3 RBMY1A1 RBMY1C RBMY1F SYNCRIP HNRNPR	1.49e-16	213	21	11	725
Coexpression	CHEN_ETV5_TARGETS_TESTIS	RBMY1D RBMY1B RBMY1E RBMY1A1	3.58e-08	33	27	4	MM701
Coexpression	ZHENG_IL22_SIGNALING_DN	RBMY1D RBMY1B RBMY1E RBMY1A1	1.29e-07	45	27	4	MM763
Coexpression	ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN	RBMY1D RBMY1B RBMY1E CCDC80 ST6GALNAC3 RBMY1A1 RBMY1F	2.20e-05	873	27	7	M16009
Coexpression	MIKKELSEN_NPC_LCP_WITH_H3K4ME3	ECRG4 SEC16B SARDH	3.21e-05	60	27	3	M2018
Coexpression	MIKKELSEN_NPC_LCP_WITH_H3K4ME3	ECRG4 SEC16B SARDH	3.54e-05	62	27	3	MM865
Computational	Neighborhood of SMC1L1	SRSF1 SYNCRIP HNRNPR	6.36e-05	62	14	3	MORF_SMC1L1
Computational	Neighborhood of KPNB1	SRSF1 SYNCRIP HNRNPR	1.04e-04	73	14	3	GNF2_KPNB1
Computational	Neighborhood of APEX1	SRSF1 SYNCRIP HNRNPR	2.06e-04	92	14	3	GNF2_APEX1
Computational	Neighborhood of MAX	CLK4 HNRNPR	7.17e-04	31	14	2	GCM_MAX
Computational	Neighborhood of FBL	SRSF1 SYNCRIP HNRNPR	8.01e-04	146	14	3	GNF2_FBL
Computational	Breast cancer expression clusters.	ECRG4 MYO15A	8.13e-04	33	14	2	MODULE_366
Computational	Neighborhood of TDG	SRSF1 HNRNPR	9.15e-04	35	14	2	GNF2_TDG
Computational	Neighborhood of ELAC2	SRSF1 HNRNPR	1.58e-03	46	14	2	GNF2_ELAC2
Computational	Neighborhood of DENR	SYNCRIP HNRNPR	1.94e-03	51	14	2	GNF2_DENR
Computational	Neighborhood of DEK	SRSF1 HNRNPR	2.50e-03	58	14	2	GNF2_DEK
Computational	RNA splicing.	SRSF1 HNRNPR	3.13e-03	65	14	2	MODULE_183
Computational	TFs and nuclear.	SRSF1 CDC25C HNRNPR	3.22e-03	237	14	3	MODULE_252
Computational	Neighborhood of NPM1	SRSF1 HNRNPR	3.82e-03	72	14	2	GNF2_NPM1
Computational	Neighborhood of XRCC5	SRSF1 SYNCRIP	4.14e-03	75	14	2	GNF2_XRCC5
Computational	Neighborhood of DEK	SRSF1 SYNCRIP HNRNPR	4.36e-03	264	14	3	MORF_DEK
Computational	Neighborhood of PCNA	SRSF1 SYNCRIP	5.05e-03	83	14	2	MORF_PCNA
Computational	Genes in the cancer module 198.	SRSF1 CDC25C HNRNPR	6.41e-03	303	14	3	MODULE_198
Computational	Neighborhood of UBE2N	SRSF1 HNRNPR	6.56e-03	95	14	2	MORF_UBE2N
Drug	hydantoin-5-propionic acid	RBMY1D RBMY1B RBMY1E RBMY1A1	9.26e-09	21	27	4	CID000000782
Drug	AZFd	RBMY1D RBMY1B RBMY1E RBMY1A1	1.37e-08	23	27	4	CID000196489
Drug	Vistar	RBMY1D RBMY1B RBMY1E RBMY1A1	9.00e-08	36	27	4	CID000040896
Drug	2-chlorodideoxyadenosine	RBMY1D RBMY1B RBMY1E RBMY1A1	1.87e-07	43	27	4	CID000072194
Drug	PKI166	RBMY1D RBMY1B RBMY1E RBMY1A1	2.94e-07	48	27	4	CID006918403
Drug	HgCl	RBMY1D RBMY1B RBMY1E RBMY1A1	3.20e-07	49	27	4	CID000024182
Drug	azafagomine	RBMY1D RBMY1B RBMY1E RBMY1A1	5.93e-07	57	27	4	CID011957435
Drug	thioglycolate	RBMY1D RBMY1B RBMY1E RBMY1A1	1.14e-06	67	27	4	CID000001133
Drug	SU6668	RBMY1D RBMY1B RBMY1E RBMY1A1	1.36e-06	70	27	4	CID000206042
Drug	AC1NRA5C	RBMXL2 SRSF1 ST6GALNAC3 SYNCRIP HNRNPR	1.73e-06	174	27	5	CID005287709
Drug	p11-13	RBMY1D RBMY1B RBMY1E RBMY1A1	1.80e-06	75	27	4	CID000015759
Drug	bipy	RBMY1D RBMY1B RBMY1E RBMY1A1	5.04e-06	97	27	4	CID000001474
Drug	2-oyl	RBMY1D RBMY1B RBMY1E RBMY1A1	6.91e-06	105	27	4	CID000657137
Drug	carbonyl sulfide	RBMY1D RBMY1B RBMY1E RBMY1A1	1.03e-05	116	27	4	CID000010039
Drug	AC1LDH4A	ST6GALNAC3 CLK4	2.83e-05	7	27	2	CID000647991
Drug	AC1L1AUZ	RBMXL2 SRSF1 SYNCRIP HNRNPR	3.37e-05	157	27	4	CID000001160
Drug	oligoadenylate	RBMY1D RBMY1B RBMY1E RBMY1A1	3.37e-05	157	27	4	CID000107918
Drug	Fenoprofen calcium salt dihydrate [53746-45-5]; Down 200; 7.2uM; MCF7; HT_HG-U133A	SRSF1 CDC25C HNRNPUL2 PCLO	7.69e-05	194	27	4	4736_DN
Drug	naphthalene acetic acid	CCDC80 SRSF1 CDC25C	1.07e-04	78	27	3	CID000006862
Drug	glutamin	RBMY1D RBMY1B RBMY1E ST6GALNAC3 RBMY1A1	1.86e-04	461	27	5	CID000000738
Disease	Nonsyndromic Deafness	MYO15A OTOGL	1.51e-03	81	21	2	C3711374
Disease	language measurement	SEC16B ST6GALNAC3	4.06e-03	134	21	2	EFO_0007797
Disease	nasopharyngeal neoplasm	RHBDD1 PCLO	5.13e-03	151	21	2	EFO_0004252
Disease	smoking status measurement, diastolic blood pressure	NEDD9 ARID1B	5.67e-03	159	21	2	EFO_0006336, EFO_0006527
Disease	Malignant neoplasm of breast	ARID1B SRSF1 OTOGL HNRNPR	6.37e-03	1074	21	4	C0006142

Protein segments in the cluster

Peptide	Gene	Start	Entry
NRDRNGHEYYGDYYQ	ECRG4	106	Q9H1Z8
GHGYVYEYPSRYQKD	NEDD9	161	Q14511
YGASYDRRHEPYGQQ	ARID1B	1401	Q8NFD5
DEYAGYGYHSYHQGY	CCDC80	916	Q76M96
YHQGYQDGYQDDYRH	CCDC80	926	Q76M96
DYAPPHRDYAYRDYG	RBMY1A1	341	P0DJD3
DYAPPHRDYAYRDYG	RBMY1B	341	A6NDE4
DYAPPHRDYAYRDYG	RBMY1C	341	P0DJD4
DYAPPHRDYAYRDYG	RBMY1D	341	P0C7P1
DYAPPHRDYAYRDYG	RBMY1E	341	A6NEQ0
DYAPPHRDYAYRDYG	RBMY1F	341	Q15415
GYSSPYSYHDGYEGE	MYO15A	321	Q9UKN7
YSYHDGYEGEAHPYG	MYO15A	326	Q9UKN7
GYDYHNYRGGYEDPY	SYNCRIP	471	O60506
RFGYRDDHYQYDRSG	PCLO	2966	Q9Y6V0
DDHYQYDRSGPYGYR	PCLO	2971	Q9Y6V0
GYRNFYDRYRGDYDR	HNRNPUL2	686	Q1KMD3
YDRYRGDYDRFYGRD	HNRNPUL2	691	Q1KMD3
GDYDRFYGRDYEYNR	HNRNPUL2	696	Q1KMD3
GYDYHDYRGGYEDPY	HNRNPR	476	O43390
SPYAYGVLDRGYRYD	PSMB11	181	A5LHX3
YVIDCRYPYEYLGGH	CDC25C	326	P30307
YQGHQYFLRRGEYPD	CRYGB	51	P07316
YRNDYCEGYVPRHYH	CLK4	76	Q9HAZ1
YGDRHYYSFDGLEYD	OTOGL	951	Q3ZCN5
GYQDYYPHGRPDHYE	RHBDD1	241	Q8TEB9
EGYRKVPYHYYEQGR	ST6GALNAC3	246	Q8NDV1
GRYEEYRGYSPDAYS	RBMXL2	306	O75526
EYDYYGAYGSRAHED	SARDH	521	Q9UL12
GAYGSRAHEDYAYRR	SARDH	526	Q9UL12
YGQSHRYGGEGRYEY	RBMXL3	541	Q8N7X1
REEYAYGSYYYHGHP	SEC16B	116	Q96JE7
VYGRDGYDYDGYRLR	SRSF1	71	Q07955
DYFYRPETQHREGYN	GTF3C5	181	Q9Y5Q8