Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ATG_C	ATG2B VPS13B	1.80e-04	5	80	2	PF09333
Domain	Laminin_aI	LAMA1 LAMA5	1.80e-04	5	80	2	IPR009254
Domain	Laminin_I	LAMA1 LAMA5	1.80e-04	5	80	2	PF06008
Domain	Laminin_II	LAMA1 LAMA5	1.80e-04	5	80	2	PF06009
Domain	Laminin_domII	LAMA1 LAMA5	1.80e-04	5	80	2	IPR010307
Domain	Autophagy-rel_C	ATG2B VPS13B	1.80e-04	5	80	2	IPR015412
Domain	VPS13_N	ATG2B VPS13B	4.99e-04	8	80	2	IPR026854
Domain	Chorein_N	ATG2B VPS13B	4.99e-04	8	80	2	PF12624
Domain	LAMININ_IVA	LAMA1 LAMA5	4.99e-04	8	80	2	PS51115
Domain	Laminin_B	LAMA1 LAMA5	4.99e-04	8	80	2	PF00052
Domain	LamB	LAMA1 LAMA5	4.99e-04	8	80	2	SM00281
Domain	Laminin_IV	LAMA1 LAMA5	4.99e-04	8	80	2	IPR000034
Domain	Galactose-bd-like	MEP1B PTPRK LAMA1 LAMA5	7.10e-04	94	80	4	IPR008979
Domain	AcylCoA_DH/ox_N	ACAD11 ACOX1	1.37e-03	13	80	2	IPR013786
Domain	-	ACAD11 ACOX1	1.37e-03	13	80	2	1.10.540.10
Domain	6-hairpin_glycosidase-like	MOGS LANCL1	1.37e-03	13	80	2	IPR008928
Domain	Acyl-CoA_Oxase/DH_cen-dom	ACAD11 ACOX1	1.83e-03	15	80	2	IPR006091
Domain	Acyl-CoA_dh_M	ACAD11 ACOX1	1.83e-03	15	80	2	PF02770
Domain	AcylCoA_DH/oxidase_NM_dom	ACAD11 ACOX1	1.83e-03	15	80	2	IPR009100
Domain	MAM_1	MEP1B PTPRK	2.09e-03	16	80	2	PS00740
Domain	Laminin_N	LAMA1 LAMA5	2.09e-03	16	80	2	IPR008211
Domain	LAMININ_NTER	LAMA1 LAMA5	2.09e-03	16	80	2	PS51117
Domain	Laminin_N	LAMA1 LAMA5	2.09e-03	16	80	2	PF00055
Domain	AcylCo_DH/oxidase_C	ACAD11 ACOX1	2.09e-03	16	80	2	IPR009075
Domain	LamNT	LAMA1 LAMA5	2.09e-03	16	80	2	SM00136
Domain	MAM	MEP1B PTPRK	2.36e-03	17	80	2	SM00137
Domain	ConA-like_dom	MEP1B PTPRK LAMA1 LAMA5 RYR3	2.50e-03	219	80	5	IPR013320
Domain	MAM	MEP1B PTPRK	2.65e-03	18	80	2	PF00629
Domain	MAM_dom	MEP1B PTPRK	2.65e-03	18	80	2	IPR000998
Domain	MAM_2	MEP1B PTPRK	2.65e-03	18	80	2	PS50060
Domain	HATPase_c	TRAP1 PDK2	2.65e-03	18	80	2	SM00387
Domain	HATPase_c	TRAP1 PDK2	2.96e-03	19	80	2	PF02518
Domain	-	TRAP1 PDK2	3.27e-03	20	80	2	3.30.565.10
Domain	HATPase_C	TRAP1 PDK2	3.61e-03	21	80	2	IPR003594
Domain	TIR_dom	IL17RD TLR8	5.10e-03	25	80	2	IPR000157
Domain	EGF_LAM_2	LAMA1 LAMA5	7.29e-03	30	80	2	PS50027
Domain	EGF_LAM_1	LAMA1 LAMA5	7.29e-03	30	80	2	PS01248
Domain	RA	RADIL MYO9B	7.77e-03	31	80	2	SM00314
Domain	-	ATP9B ATP13A2	8.27e-03	32	80	2	3.40.1110.10
Domain	-	ATP9B ATP13A2	8.27e-03	32	80	2	2.70.150.10
Pubmed	Proteomic analysis of the mitochondrial glucocorticoid receptor interacting proteins reveals pyruvate dehydrogenase and mitochondrial 60 kDa heat shock protein as potent binding partners.	ACSL4 LRPPRC TRAP1 C3 HSPA4	1.72e-06	83	83	5	35124280
Pubmed	Defining brain wiring patterns and mechanisms through gene trapping in mice.	PTPRK LAMA1 IL17RD	4.68e-06	14	83	3	11242070
Pubmed	The laminin response in inflammatory bowel disease: protection or malignancy?	LAMA1 LAMA5	5.63e-06	2	83	2	25347196
Pubmed	C3d fragment of complement interacts with laminin and binds to basement membranes of glomerulus and trophoblast.	LAMA1 C3	5.63e-06	2	83	2	3488995
Pubmed	[Correlation between ultrastructural changes of glomerular basement membrane and abnormal distribution of laminins in patients with Alport's syndrome].	LAMA1 LAMA5	5.63e-06	2	83	2	20019771
Pubmed	The hedgehog processing pathway is required for NSCLC growth and survival.	HHAT DISP1	5.63e-06	2	83	2	22733134
Pubmed	Presynaptic congenital myasthenic syndrome with a homozygous sequence variant in LAMA5 combines myopia, facial tics, and failure of neuromuscular transmission.	LAMA1 LAMA5	5.63e-06	2	83	2	28544784
Pubmed	White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder.	FRRS1 ADAMTS9 CAMK2D	5.84e-06	15	83	3	23218918
Pubmed	ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice.	ADAMTS9 LAMA1 LAMA5	7.18e-06	16	83	3	30579834
Pubmed	Heterologously overexpressed, affinity-purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitro.	LAMA1 LAMA5	1.69e-05	3	83	2	10620696
Pubmed	Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences.	LAMA1 LAMA5	1.69e-05	3	83	2	9006922
Pubmed	Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells.	LAMA1 LAMA5	1.69e-05	3	83	2	12393739
Pubmed	α1- and α5-containing laminins regulate the development of bile ducts via β1 integrin signals.	LAMA1 LAMA5	1.69e-05	3	83	2	22761447
Pubmed	Hyperglycemia regulates cardiac K+ channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways.	CAMK2D LEPR	1.69e-05	3	83	2	33237428
Pubmed	Phosphorylation of T107 by CamKIIδ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1.	CAMK2D LEPR	1.69e-05	3	83	2	32966793
Pubmed	Expression of laminin alpha 1, alpha 5 and beta 2 chains during embryogenesis of the kidney and vasculature.	LAMA1 LAMA5	1.69e-05	3	83	2	9049978
Pubmed	Acylation stimulating protein (ASP) acute effects on postprandial lipemia and food intake in rodents.	C3 LEPR	1.69e-05	3	83	2	11360154
Pubmed	Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis.	GRHL3 LEPR	1.69e-05	3	83	2	25658689
Pubmed	Functional genetic analysis of mouse chromosome 11.	MED31 ZDHHC13 ALG10B	2.24e-05	23	83	3	12955145
Pubmed	Expression of laminin chains by central neurons: analysis with gene and protein trapping techniques.	LAMA1 LAMA5	3.37e-05	4	83	2	12820173
Pubmed	E6-AP association promotes SOD1 aggresomes degradation and suppresses toxicity.	UBE3A HSPA4	3.37e-05	4	83	2	23040663
Pubmed	Newly synthesized human delta opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome.	HSPA4 OPRD1	3.37e-05	4	83	2	11054417
Pubmed	Laminin compensation in collagen alpha3(IV) knockout (Alport) glomeruli contributes to permeability defects.	LAMA1 LAMA5	3.37e-05	4	83	2	17699809
Pubmed	Laminin-1 reexpression in Alport mouse glomerular basement membranes.	LAMA1 LAMA5	3.37e-05	4	83	2	12631063
Pubmed	Developmental regulation of the laminin alpha5 chain suggests a role in epithelial and endothelial cell maturation.	LAMA1 LAMA5	3.37e-05	4	83	2	9299121
Pubmed	The ubiquitin ligase E6-AP is induced and recruited to aggresomes in response to proteasome inhibition and may be involved in the ubiquitination of Hsp70-bound misfolded proteins.	UBE3A HSPA4	3.37e-05	4	83	2	19233847
Pubmed	Mini-review: toward understanding mechanisms of genetic neural tube defects in mice.	LAMA5 GRHL3	3.37e-05	4	83	2	10525207
Pubmed	Expression and distribution of laminin alpha1 and alpha2 chains in embryonic and adult mouse tissues: an immunochemical approach.	LAMA1 LAMA5	5.60e-05	5	83	2	11969289
Pubmed	Differential expression of five laminin alpha (1-5) chains in developing and adult mouse kidney.	LAMA1 LAMA5	5.60e-05	5	83	2	9415429
Pubmed	Differential expression of laminin alpha chains during murine tooth development.	LAMA1 LAMA5	5.60e-05	5	83	2	9389447
Pubmed	Complement Component C3 Is Highly Expressed in Human Pancreatic Islets and Prevents β Cell Death via ATG16L1 Interaction and Autophagy Regulation.	C3 LEPR	5.60e-05	5	83	2	30293775
Pubmed	Genetic loci contributing to age-related hippocampal lesions in mice.	SYT3 UBE3A	5.60e-05	5	83	2	12828934
Pubmed	Posttranslational modifications and beta/gamma chain associations of human laminin alpha1 and laminin alpha5 chains: purification of laminin-3 from placenta.	LAMA1 LAMA5	5.60e-05	5	83	2	10964500
Pubmed	Laminin gamma2 expression is developmentally regulated during murine tooth morphogenesis and is intense in ameloblasts.	LAMA1 LAMA5	5.60e-05	5	83	2	9719032
Pubmed	Laminin-10 is crucial for hair morphogenesis.	LAMA1 LAMA5	5.60e-05	5	83	2	12743034
Pubmed	Dominant mutations in GRHL3 cause Van der Woude Syndrome and disrupt oral periderm development.	IRX6 GRHL3	5.60e-05	5	83	2	24360809
Pubmed	Complete sequence, recombinant analysis and binding to laminins and sulphated ligands of the N-terminal domains of laminin alpha3B and alpha5 chains.	LAMA1 LAMA5	5.60e-05	5	83	2	11829758
Pubmed	The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking.	LRPPRC ACAD11 CAMK2D PIP HSPA4	6.79e-05	177	83	5	26485645
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	FLNB LRPPRC TRAP1 UBE3A PDK2 CAMK2D CASKIN1 ATG2B SMPD2 SLC16A7 GABRA2	8.28e-05	1139	83	11	36417873
Pubmed	HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium.	LAMA1 LAMA5	8.39e-05	6	83	2	9597096
Pubmed	cis-acting sequences and trans-acting factors in the localization of mRNA for mitochondrial ribosomal proteins.	TRAP1 HSPA4	8.39e-05	6	83	2	18790094
Pubmed	Laminin alpha1 globular domains 4-5 induce fetal development but are not vital for embryonic basement membrane assembly.	LAMA1 LAMA5	8.39e-05	6	83	2	15668394
Pubmed	Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice.	C3 LEPR	8.39e-05	6	83	2	27644882
Pubmed	Laminin is the ECM niche for trophoblast stem cells.	LAMA1 LAMA5	8.39e-05	6	83	2	31937556
Pubmed	Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles.	TRAP1 AFP ACOX1	9.60e-05	37	83	3	19865483
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	ORC5 LRPPRC TRAP1 MOGS TTC28 CAMK2D ATG2B HSDL1	1.02e-04	606	83	8	36538041
Pubmed	Defining the membrane proteome of NK cells.	ACSL4 LRPPRC TRAP1 MOGS MYO9B CAMK2D ACOX1 ALG9 OASL CHST11 ZDHHC13	1.03e-04	1168	83	11	19946888
Pubmed	KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer.	FLNB LRPPRC TRAP1 HSPA4	1.16e-04	104	83	4	36055981
Pubmed	Lung dendritic-cell metabolism underlies susceptibility to viral infection in diabetes.	PDK2 LEPR	1.17e-04	7	83	2	38093014
Pubmed	Abscence of laminin alpha1 chain in the skeletal muscle of dystrophic dy/dy mice.	LAMA1 LAMA5	1.17e-04	7	83	2	9390664
Pubmed	Laminin isoforms in fetal and adult human adrenal cortex.	LAMA1 LAMA5	1.17e-04	7	83	2	14557481
Pubmed	Ontogeny of mRNA expression and activity of long-chain acyl-CoA synthetase (ACSL) isoforms in Mus musculus heart.	ACSL4 ACOX1	1.17e-04	7	83	2	17197235
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ACSL4 DNAH12 ACAD11 TTC28 UBE3A POT1 LANCL1 IL17RD	1.45e-04	638	83	8	31182584
Pubmed	Laminin-1 promotes differentiation of fetal mouse pancreatic beta-cells.	LAMA1 LAMA5	1.56e-04	8	83	2	10102687
Pubmed	Expression and localization of laminin-5 subunits during mouse tooth development.	LAMA1 LAMA5	1.56e-04	8	83	2	9489770
Pubmed	Beta1 integrins are required for the invasion of the caecum and proximal hindgut by enteric neural crest cells.	LAMA1 LAMA5	1.56e-04	8	83	2	19633172
Pubmed	Cloning and expression analyses of mouse dystroglycan gene: specific expression in maternal decidua at the peri-implantation stage.	LAMA1 LAMA5	1.56e-04	8	83	2	8872465
Pubmed	A mutation affecting laminin alpha 5 polymerisation gives rise to a syndromic developmental disorder.	LAMA1 LAMA5	1.56e-04	8	83	2	32439764
Pubmed	Roles for laminin in embryogenesis: exencephaly, syndactyly, and placentopathy in mice lacking the laminin alpha5 chain.	LAMA1 LAMA5	1.56e-04	8	83	2	9852162
Pubmed	Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment.	LAMA1 LAMA5	1.56e-04	8	83	2	19651211
Pubmed	TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.	ATG101 ACAD11 PIP LANCL1	1.82e-04	117	83	4	36898370
Pubmed	Expression of laminin alpha1, alpha2, alpha4, and alpha5 chains, fibronectin, and tenascin-C in skeletal muscle of dystrophic 129ReJ dy/dy mice.	LAMA1 LAMA5	2.00e-04	9	83	2	9882526
Pubmed	Compositional and structural requirements for laminin and basement membranes during mouse embryo implantation and gastrulation.	LAMA1 LAMA5	2.00e-04	9	83	2	15102706
Pubmed	Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome.	LAMA1 LAMA5	2.00e-04	9	83	2	10880400
Pubmed	Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality.	LAMA1 LAMA5	2.00e-04	9	83	2	30456378
Pubmed	Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins.	LAMA1 C3	2.00e-04	9	83	2	8661125
Pubmed	Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors.	ATG101 TYMS MOGS ICE2 OPRD1 FBXL4	2.24e-04	359	83	6	35559673
Pubmed	Functional consequences of cell type-restricted expression of laminin α5 in mouse placental labyrinth and kidney glomerular capillaries.	LAMA1 LAMA5	2.50e-04	10	83	2	22911783
Pubmed	Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro.	LAMA1 LAMA5	2.50e-04	10	83	2	18590826
Pubmed	Trophoblast-specific expression and function of the integrin alpha 7 subunit in the peri-implantation mouse embryo.	LAMA1 LAMA5	2.50e-04	10	83	2	11784026
Pubmed	Primary cellular meningeal defects cause neocortical dysplasia and dyslamination.	LAMA1 LAMA5	2.50e-04	10	83	2	20976766
Pubmed	Distribution of the ten known laminin chains in the pathways and targets of developing sensory axons.	LAMA1 LAMA5	2.50e-04	10	83	2	9034910
Pubmed	Generation of a conditionally null allele of the laminin alpha1 gene.	LAMA1 LAMA5	2.50e-04	10	83	2	16100707
Pubmed	Integrin alpha6beta1-laminin interactions regulate early myotome formation in the mouse embryo.	LAMA1 LAMA5	2.50e-04	10	83	2	16554364
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	FLNB PIP LAMA1 LEPR VPS13B	2.50e-04	234	83	5	36243803
Pubmed	Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development.	FLNB LRPPRC HSPA4	2.98e-04	54	83	3	31792442
Pubmed	Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.	POT1 HSPA4	3.05e-04	11	83	2	15383534
Pubmed	Mutations in LAMB1 cause cobblestone brain malformation without muscular or ocular abnormalities.	LAMA1 LAMA5	3.05e-04	11	83	2	23472759
Pubmed	Laminin alpha 5 is required for lobar septation and visceral pleural basement membrane formation in the developing mouse lung.	LAMA1 LAMA5	3.05e-04	11	83	2	12051813
Pubmed	Regional differences in the expression of laminin isoforms during mouse neural tube development.	LAMA1 LAMA5	3.05e-04	11	83	2	21524702
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	TYMS MOGS ALG9 OASL ATP9B SMPD2 CHST11 ZDHHC13	3.24e-04	719	83	8	35337019
Pubmed	Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis.	LAMA1 LAMA5	3.66e-04	12	83	2	11381080
Pubmed	Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse.	LAMA1 LAMA5	3.66e-04	12	83	2	10433923
Pubmed	Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function.	LAMA1 LAMA5	3.66e-04	12	83	2	16750824
Pubmed	Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice.	LAMA1 LAMA5	3.66e-04	12	83	2	9396756
Pubmed	The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut.	LAMA1 LAMA5	4.31e-04	13	83	2	36350252
Pubmed	Fukutin-related protein alters the deposition of laminin in the eye and brain.	LAMA1 LAMA5	4.31e-04	13	83	2	21900571
Pubmed	Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane.	LAMA1 LAMA5	4.31e-04	13	83	2	12682087
Pubmed	The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform.	LAMA1 LAMA5	5.03e-04	14	83	2	9151674
Pubmed	Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome.	LAMA1 LAMA5	5.03e-04	14	83	2	19783738
Pubmed	Epithelial Migration and Non-adhesive Periderm Are Required for Digit Separation during Mammalian Development.	LAMA1 GRHL3	5.03e-04	14	83	2	32109382
Pubmed	Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.	LRPPRC MYO9B PIP HSPA4	5.43e-04	156	83	4	22952844
Pubmed	Laminin alpha5 chain is required for intestinal smooth muscle development.	LAMA1 LAMA5	5.79e-04	15	83	2	12921739
Pubmed	Basement membrane composition in the early mouse embryo day 7.	LAMA1 LAMA5	5.79e-04	15	83	2	15895400
Pubmed	Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane.	LAMA1 LAMA5	5.79e-04	15	83	2	10625553
Pubmed	Localization of basement membrane-associated protein isoforms during development of the ocular surface of mouse eye.	LAMA1 LAMA5	5.79e-04	15	83	2	9264260
Pubmed	The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation.	LAMA1 LAMA5	6.61e-04	16	83	2	19733164
Pubmed	Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling.	LAMA1 LAMA5	6.61e-04	16	83	2	17601529
Pubmed	Asprosin-neutralizing antibodies as a treatment for metabolic syndrome.	LEPR GABRA2	6.61e-04	16	83	2	33904407
Pubmed	Laminin α1 is essential for mouse cerebellar development.	LAMA1 LAMA5	7.48e-04	17	83	2	21983115
Cytoband	3p14.3	FLNB DNAH12 IL17RD	2.23e-05	30	83	3	3p14.3
Cytoband	Ensembl 112 genes in cytogenetic band chr3p14	FLNB DNAH12 ADAMTS9 IL17RD	1.26e-04	140	83	4	chr3p14
GeneFamily	Laminin subunits	LAMA1 LAMA5	6.10e-04	12	56	2	626
Coexpression	NIKOLSKY_MUTATED_AND_AMPLIFIED_IN_BREAST_CANCER	RADIL MYO9B PPM1E PKHD1L1 VPS13B	1.24e-05	94	83	5	M18108
Coexpression	GSE15330_HSC_VS_MEGAKARYOCYTE_ERYTHROID_PROGENITOR_UP	TGFBR3 TTC28 AFP ICE2 ZBTB4 SSH2	1.29e-05	162	83	6	M7005
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	ACSL4 TGFBR3 ORC5 FLNB LRPPRC TTC28 PTPRK PLPP3 UBE3A MYO9B SLC16A7 VPS13B	1.57e-05	856	83	12	M4500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e15.5_Urothelium_emap-28091_top-relative-expression-ranked_200	MEP1B AFP POT1 GRHL3 RBM47 SLC16A7 TTC6	2.32e-06	157	81	7	gudmap_developingLowerUrinaryTract_e15.5_urothelium_200
CoexpressionAtlas	DevelopingLowerUrinaryTract_P2_bladder urothelium (LCM)_emap-30380_top-relative-expression-ranked_1000	MEP1B ACSL4 PTPRK CAMK2D ACOX1 ZBTB4 FBP2 GRHL3 RBM47 SLC16A7 LEPR TTC6	3.73e-05	778	81	12	gudmap_developingLowerUrinaryTract_P2_bladder urothelium (LCM)_1000
ToppCell	RA-10._Endothelium_II\|World / Chamber and Cluster_Paper	FLNB PLPP3 ADAMTS9 PKHD1L1 SH3RF3 LEPR	1.46e-06	189	83	6	75c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell	RA-10._Endothelium_II\|RA / Chamber and Cluster_Paper	FLNB PLPP3 ADAMTS9 PKHD1L1 SH3RF3 LEPR	1.46e-06	189	83	6	c81787a8c662db5d7814c583dd64562857629e81
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MYO9B ATP9B CHST11 SSH2 RBM47 VPS13B	1.65e-06	193	83	6	779276e775cb2492e8dd36436295a536084a6415
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	OVCH2 PLPP3 LAMA1 IL17RD RYR3 OPRD1	1.81e-06	196	83	6	a58bdf9de05d13d84211e09a933679d485bf8ab4
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TGFBR3 RADIL PLPP3 C3 LEPR	1.76e-05	172	83	5	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	Endothelial-A-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	TGFBR3 ADAMTS9 LEPR RYR3 GABRA2	2.49e-05	185	83	5	ae49c61f6ecf128fe2a958b8c75c83688da75f59
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TGFBR3 ADAMTS9 MYO9B SH3RF3 RYR3	2.49e-05	185	83	5	e58a009aaf342be019a909747b1895d5987d4daf
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_NK-T_mait-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ORC5 FLNB ACAD11 POT1 LANCL1	2.56e-05	186	83	5	927723ad579bbd9947ff525bd501e222d3fa9289
ToppCell	COVID-19-lung-Vein_EC\|lung / Disease (COVID-19 only), tissue and cell type	TGFBR3 FLNB ADAMTS9 PKHD1L1 SH3RF3	2.69e-05	188	83	5	d582b76fc2faac526c9bf97503041129e1a6a211
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	TCP11L2 TTC28 PTPRK AFP HSPA4	2.98e-05	192	83	5	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TGFBR3 PKHD1L1 SH3RF3 RYR3 HAPLN1	2.98e-05	192	83	5	25cb6cc6cbf8dc20139d938adfc02ed7a8c3dfb6
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TGFBR3 ADAMTS9 PKHD1L1 SH3RF3 LEPR	3.05e-05	193	83	5	9ba688b35a9ead5d04691b3f3f15484f02dbbd0d
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTS9 LAMA5 PKHD1L1 LEPR RYR3	3.05e-05	193	83	5	c0973a2c97deb7176c2f617c8760a55f7edc9839
ToppCell	RV-10._Endothelium_II\|World / Chamber and Cluster_Paper	FLNB PLPP3 ADAMTS9 PKHD1L1 LEPR	3.05e-05	193	83	5	2531266bc57339d4e2b22a88817008e32b8c1598
ToppCell	IPF-Stromal-Fibroblast\|Stromal / Disease state, Lineage and Cell class	TGFBR3 FLNB C3 SLC16A7 LEPR	3.13e-05	194	83	5	da3e1d39575969a069ef43e552afe94b2f441d0b
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-secretory_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ORC5 PTPRK CAMK2D GRHL3 ZDHHC13	3.29e-05	196	83	5	547901c7a665770eff78eede69b8625b416c8186
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ORC5 PTPRK CAMK2D GRHL3 ZDHHC13	3.29e-05	196	83	5	6e08d7ba67da161c2dca1a17c440ffb9d9b5bc3b
ToppCell	nucseq-Endothelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TGFBR3 TTC28 ADAMTS9 PKHD1L1 SH3RF3	3.37e-05	197	83	5	ebf9be068eaa658493fa7884fd19f34642922acb
ToppCell	(5)_Dendritic_cell-(54)_pDC\|(5)_Dendritic_cell / shred on Cell_type and subtype	FLNB TTC28 HHAT ATG2B ATP13A2	3.45e-05	198	83	5	fc6c6b60dddd7f2f997af0f87fae33f1c23f34a8
ToppCell	5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLPP3 ADAMTS9 LAMA5 LEPR RYR3	3.53e-05	199	83	5	07bda4ac8ffdce1a865ebc99e46c2a27925ff7a8
ToppCell	NS-control-d_0-4-Epithelial-Secretory\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FLNB PTPRK PLPP3 C3 SLC16A7	3.53e-05	199	83	5	32bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCell	control-Epithelial-Secretory\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FLNB PTPRK PLPP3 C3 SLC16A7	3.53e-05	199	83	5	3d01f90ffd271ca00129192787e4921bdca7e01e
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FLNB TTC28 ADAMTS9 FBP2 LEPR	3.62e-05	200	83	5	5ec31c1be6bcc4124e1489d136570f3de33cc2e9
ToppCell	distal-Endothelial-Vein-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FLNB PLPP3 ADAMTS9 PKHD1L1 LEPR	3.62e-05	200	83	5	ff88d28162e0231d5dac0e0c6bec98fa8da58a23
ToppCell	medial-Endothelial-Vein-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FLNB PLPP3 ADAMTS9 PKHD1L1 LEPR	3.62e-05	200	83	5	3f689029f5bc7db0af50a405f1e252aeec529077
ToppCell	distal-2-Endothelial-Vein\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FLNB PLPP3 ADAMTS9 PKHD1L1 LEPR	3.62e-05	200	83	5	2785225956d2422acab90e99b7debe3709cf3308
ToppCell	medial-Endothelial-Vein\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FLNB PLPP3 ADAMTS9 PKHD1L1 LEPR	3.62e-05	200	83	5	1163e5f6dfb304c94bf8885629350454f4b6bee8
ToppCell	medial-2-Endothelial-Vein\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FLNB PLPP3 ADAMTS9 PKHD1L1 LEPR	3.62e-05	200	83	5	49da4e3ff10262a492c2cf566a7f2e35e418bfda
ToppCell	LPS_only-Unknown-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BPIFC PPM1E TLR8 TDRD12	6.37e-05	115	83	4	ad5298c2ad8bf94fa13c2e50b0799e929473ef59
ToppCell	LPS_only-Unknown\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BPIFC PPM1E TLR8 TDRD12	6.37e-05	115	83	4	7a733f6987b40ec497a03734b79ed5355ad3a2fc
ToppCell	LPS_only-Unknown-Endothelial-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BPIFC PPM1E TLR8 TDRD12	6.37e-05	115	83	4	c67145d3cd9243994a141749b426ff2a6dcc8d93
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast-FB-1\|E18.5-samps / Age Group, Lineage, Cell class and subclass	TCP11L2 SYT3 MED31 DISP1	2.22e-04	159	83	4	b4bc888e978b1b577721b891b0af6ba9a1607044
ToppCell	mild-Myeloid-Eosinophils\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MS4A3 MYO9B SSH2 RYR3	2.44e-04	163	83	4	7c57d541a88e9afa079e95b8a6ecdea60a0c6aaa
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS9 LAMA1 C3 RYR3	2.50e-04	164	83	4	1cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Plasma_cells-IgM_plasma_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DNAH12 TTC28 ALG9 PKHD1L1	2.56e-04	165	83	4	6e8370b8e747d8ef44a2413a993291a3cd83a77c
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TYMS FLNB ACAD11 POT1	2.56e-04	165	83	4	62457b7b74c6eae42d91d65e7dc6df6bf8e061f7
ToppCell	390C-Lymphocytic-Plasma_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FRRS1 IGKV1D-43 RBM47 PKHD1L1	2.62e-04	166	83	4	4ba3711a02d3695b27f7cefd7c60e3be009f5bef
ToppCell	390C-Lymphocytic-Plasma_cell-\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FRRS1 IGKV1D-43 RBM47 PKHD1L1	2.62e-04	166	83	4	35f6ae2664935dda0d883b32a050ced843204f2d
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D231\|Adult / Lineage, Cell type, age group and donor	TGFBR3 SH3RF3 DISP1 HAPLN1	2.68e-04	167	83	4	5af9127bae05768a5164d5708a4ad37edca99324
ToppCell	Control-Epithelial_airway-Club_cells-Airway\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PIP C3 RBM47 TTC6	2.74e-04	168	83	4	ce87981f4da2779de952c2e5d2bbcdabb265e705
ToppCell	Control-Epithelial_airway-Club_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PIP C3 RBM47 TTC6	2.74e-04	168	83	4	e85bc5398eb36b2b0773a8a7082e3ba740452165
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TYMS PTPRK ADAMTS9 ACOX1	2.74e-04	168	83	4	08f6e171a1ea5cf65149744296d0fcd6c7b9684e
ToppCell	P07-Epithelial-epithelial_progenitor_cell-epi_progenitor\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TYMS ACSL4 FBP2 RBM47	2.80e-04	169	83	4	1a47a4892a5e6a69555f5332308503526e5422a7
ToppCell	droplet-Marrow-nan-21m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBR3 C3 SSH2 IL17RD	2.93e-04	171	83	4	355a27ea88410a84210f7e4298c7c4f90cf2f8a9
ToppCell	URO-Lymphocyte-B-Plasmablast\|URO / Disease, Lineage and Cell Type	TYMS PLPP3 FAM227A PKHD1L1	3.00e-04	172	83	4	48888ef50ac784b38aca81da68f8a94ce09c670d
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB MS4A3 LAMA5 DISP1	3.06e-04	173	83	4	a5b6c3d58f7a8e533330798b81496009a31548af
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB MS4A3 LAMA5 DISP1	3.06e-04	173	83	4	cc094992b8027f4cef38f0fb0b76f0d07210d1e2
ToppCell	TCGA-Thymus-Primary_Tumor-Thymoma-Type_AB\|TCGA-Thymus / Sample_Type by Project: Shred V9	RADIL IL17RD LEPR DISP1	3.20e-04	175	83	4	50f9b994bdd389158f92f891944ea81b2fb15eef
ToppCell	(0)_Normal/No_Treatment-(3)_LEPR+_perivascular_cells\|World / Stress and Cell class	TGFBR3 PLPP3 C3 LEPR	3.27e-04	176	83	4	ce2c32b5ce0da848eb4da35ce4d215cdf74d9113
ToppCell	severe-B_memory\|World / disease stage, cell group and cell class	FRRS1 HHAT LAMA5 FAM227A	3.27e-04	176	83	4	4e5c6b1aa5ffd13593a6bcd1e1253c1737c5c2b4
ToppCell	VE-plasma\|VE / Condition, Cell_class and T cell subcluster	LAMA5 IRX6 PKHD1L1 HAPLN1	3.34e-04	177	83	4	0c1cc0834de55717cb4f69d020339060ce2c9a03
ToppCell	VE-plasma-\|VE / Condition, Cell_class and T cell subcluster	LAMA5 IRX6 PKHD1L1 HAPLN1	3.34e-04	177	83	4	3a3c94cf30012e2aa266bc4d7fe772e45fa90f6d
ToppCell	LPS-antiTNF\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ACOX1 POT1 ATP9B RBM47	3.41e-04	178	83	4	289d1425c4e57fabcca994b27f9af1c0ce5d5bec
ToppCell	droplet-Spleen-SPLEEN-30m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRRS1 MS4A3 C3 LEPR	3.41e-04	178	83	4	be8af4d85b8835a85a168639c37857dcaa6b00bf
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB ADAMTS9 LAMA5 DISP1	3.41e-04	178	83	4	cc0382b0ee1e6c76522e2c86ad1425c45debab5d
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	OVCH2 PTPRK LAMA5 TTC6	3.48e-04	179	83	4	cb38b54261a7af5ee3347e64c8aa880a77ed0763
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TYMS MOGS PLPP3 ADAMTS9	3.56e-04	180	83	4	40d4838a0ccb10d5e49266bc8a0037d27b75ccc2
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PPM1E C3 IRX6 DISP1	3.63e-04	181	83	4	3dcb74b28f93be35ddf4de1937f7e30b25e11927
ToppCell	10x5'-bone_marrow-Myeloid_Mac-Macrophage\|bone_marrow / Manually curated celltypes from each tissue	ACSL4 ALG9 RBM47 ATP13A2	3.63e-04	181	83	4	d2aa5b53162fb5c4cbbedbd2cb4b2b614e8c4afa
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRRN3 MS4A3 CHST11 HAPLN1	3.63e-04	181	83	4	2f3d04d22d4ac016e61709ea5af3d48885c946c4
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PPM1E C3 IRX6 DISP1	3.63e-04	181	83	4	7679a5980011d6dfb1aaca7abf678c29b6f819bb
ToppCell	(00)_Basal-(0)_uninjured\|(00)_Basal / shred by cell type and Timepoint	TGFBR3 TTC28 PLPP3 C3	3.71e-04	182	83	4	c02c9cab4389d80f318f4bb8d703c1e719672624
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Mac-Cycling_Myeloid-Mac\|lymph-node_spleen / Manually curated celltypes from each tissue	TYMS OASL C3 TLR8	3.71e-04	182	83	4	84018a84e1aa52fa52ccfc26db9cd1fb6d535b31
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ACSL4 ADAMTS9 SLC16A7 GABRA2	3.79e-04	183	83	4	2f0ee40e69ad1259e56e8ee4b352736900eb8901
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FLNB RADIL ADAMTS9 PKHD1L1	3.79e-04	183	83	4	bc98df870de65aff6dab295c24cbc199c7f2aa15
ToppCell	Control-Endothelial_cells-Pulmonary_venous_endothelial_cells\|Control / group, cell type (main and fine annotations)	TGFBR3 ADAMTS9 PKHD1L1 SH3RF3	3.79e-04	183	83	4	46be9f96755c7b65aeac061d95d15abeb6466034
ToppCell	CV-Severe-3\|CV / Virus stimulation, Condition and Cluster	TYMS TBC1D16 LRPPRC LEPR	3.87e-04	184	83	4	1c9bda00bb6efd98f68781ca06655bf6c4282f27
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	LAMA1 RBM47 TTC6 OPRD1	3.87e-04	184	83	4	fa4915b0498f3069fd5ef497286445528f75187e
ToppCell	COVID-19-Fibroblasts-Adventitial_FB\|COVID-19 / group, cell type (main and fine annotations)	TGFBR3 TTC28 C3 LEPR	3.95e-04	185	83	4	a5aebf2b9b05b550d021272731d68af9a6b1229d
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FLNB LRRN3 PTPRK HSPA4	3.95e-04	185	83	4	fcd95bc074e982fc7b8fd48d2e80038b9ea35ebb
ToppCell	368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ZBTB4 LAMA5 SLC16A7 VPS13B	4.03e-04	186	83	4	77bebf576eb9b96ecb4fefb8a82a31aaaa917fc0
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CAMK2D HHAT RYR3 HAPLN1	4.03e-04	186	83	4	4d68ee3d32f7ef884faf402ef92b31b0eb4656f1
ToppCell	368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ZBTB4 LAMA5 SLC16A7 VPS13B	4.03e-04	186	83	4	13bc41c60fd628af31899a5e8b480e06cc4781be
ToppCell	Mesenchymal_cells-Adipo-CAR\|World / Lineage and Cell class	TGFBR3 PLPP3 C3 LEPR	4.03e-04	186	83	4	6ca8ce7ced91d6308b7c056032ffec1b37c974bf
ToppCell	LV-10._Endothelium_II\|World / Chamber and Cluster_Paper	FLNB ADAMTS9 PKHD1L1 LEPR	4.11e-04	187	83	4	7876dcb4800c2e54874df3d933efb79307a64a97
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	LAMA1 IRX6 RBM47 TTC6	4.11e-04	187	83	4	db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCell	pdx-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	LAMA5 IL17RD SH3RF3 LEPR	4.11e-04	187	83	4	7e376831a11ee72ed87abcdac631ca46ae29c250
ToppCell	Control-Fibroblasts-Adventitial_FB\|Control / group, cell type (main and fine annotations)	TGFBR3 C3 SH3RF3 LEPR	4.19e-04	188	83	4	706a26c372add839d947749f0521a0e1f5c9b0ec
ToppCell	COPD-Epithelial-Mesothelial\|Epithelial / Disease state, Lineage and Cell class	ACSL4 ADAMTS9 C3 PKHD1L1	4.19e-04	188	83	4	159d63ecc3653a7449fc6acefd6ef0464845260e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ACSL4 PPM1E RYR3 FBXL4	4.28e-04	189	83	4	e059be2965cca70ff5576df055d0af1775b76e00
ToppCell	P07-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell_of_alveolus\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	LRRN3 FRRS1 ATP13A2 HAPLN1	4.36e-04	190	83	4	5d25e40bc2cca314f4265e4001a546e6d99e2a79
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TGFBR3 PKHD1L1 SH3RF3 RYR3	4.36e-04	190	83	4	656483751e4bf137e4e4bfb2a03a478a8f7fcb63
ToppCell	COVID-19-lung-Vein_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TGFBR3 ADAMTS9 PKHD1L1 SH3RF3	4.36e-04	190	83	4	1caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH12 PPM1E FAM227A SMPD2	4.36e-04	190	83	4	da60bcc4b59d8e3719d8201387d567594059b1a4
ToppCell	Severe-Lymphoid-NK-Treg\|Severe / Condition, Lineage, Cell class and cell subclass	TGFBR3 TRAP1 POT1 SLC16A7	4.36e-04	190	83	4	e67803bf55a3f8e47a69ff1829c9100f870d7527
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH12 PPM1E FAM227A SMPD2	4.36e-04	190	83	4	827a1f4e4ac4beada262f4fb965dd74a447a8f4f
ToppCell	Control-Endothelial-VE_Capillary_B\|Control / Disease state, Lineage and Cell class	TTC28 PTPRK ADAMTS9 LEPR	4.45e-04	191	83	4	322237793a1278bafb14e63cab688b353e352dcc
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	OVCH2 PTPRK RBM47 TTC6	4.45e-04	191	83	4	ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCell	Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|World / Lineage, Cell type, age group and donor	OVCH2 PTPRK LAMA5 TTC6	4.45e-04	191	83	4	d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFBR3 PLPP3 C3 IRX6	4.45e-04	191	83	4	4e4488380379ed29d7898bae4e24221e7c67eb9d
ToppCell	COVID-19_Severe-B_intermediate\|World / disease group, cell group and cell class	PTPRK CAMK2D PIP HSPA4	4.45e-04	191	83	4	f226fd69a26124ba98e4544f550b89a08e6a3708
ToppCell	COVID-19-kidney-AQP1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TTC28 PLPP3 ADAMTS9 SH3RF3	4.54e-04	192	83	4	27ff3621e177e7932dd44dd6baa81551ea75a874
ToppCell	(0)_Normal/No_Treatment-(3)_LEPR+_perivascular_cells\|(0)_Normal/No_Treatment / Stress and Cell class	TGFBR3 PLPP3 C3 LEPR	4.54e-04	192	83	4	7a2ad0bdae647b88e799e62767605f2f3c5a426f
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	LAMA1 IRX6 RBM47 TTC6	4.54e-04	192	83	4	39804d9ddc67c1b41887752df2503389eae44a1a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ACSL4 PPM1E LAMA1 SLC16A7	4.54e-04	192	83	4	562df5e87038c500dd3a003fe5374cb31946b145
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D175\|Adult / Lineage, Cell type, age group and donor	PLPP3 MYO9B CHST11 RBM47	4.54e-04	192	83	4	733491e932350e3c216a626cc49c3cd3fe970a82
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TGFBR3 PLPP3 C3 LEPR	4.54e-04	192	83	4	c5f8e766453f87847b740d6988c524b3d0ef3765
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFBR3 DNAH12 PLPP3 C3	4.54e-04	192	83	4	11867f30f0b420c18cb0b34d3990237aa737a0e8
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	TTC28 PTPRK SSH2 VPS13B	4.54e-04	192	83	4	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	RV-10._Endothelium_II\|RV / Chamber and Cluster_Paper	FLNB ADAMTS9 PKHD1L1 LEPR	4.63e-04	193	83	4	01c2df9206f1527c578e808978e58196c35e72f5
Drug	Riluzole hydrochloride; Down 200; 14.8uM; MCF7; HT_HG-U133A	TAF6L ACSL4 MYO9B PDK2 ACOX1 OASL LEPR	5.50e-06	194	80	7	2295_DN
Drug	Naringin hydrate [11032-30-7]; Up 200; 6.6uM; MCF7; HT_HG-U133A	ORC5 ADAMTS9 OASL ATP9B LEPR GABRA2 HAPLN1	5.88e-06	196	80	7	5666_UP
Drug	Cyproterone acetate [427-51-0]; Down 200; 9.6uM; MCF7; HT_HG-U133A	ORC5 TTC28 MYO9B ATP9B SMPD2 ATP13A2 LEPR	6.08e-06	197	80	7	3545_DN
Drug	Cinoxacin [28657-80-9]; Up 200; 15.2uM; MCF7; HT_HG-U133A	TAF6L TTC28 PLPP3 OASL SMPD2 GABRA2 HAPLN1	6.28e-06	198	80	7	6257_UP
Drug	Finasteride	ORC5 FLNB LRPPRC FRRS1 PLPP3 UBE3A FAM210A ACOX1 ALG9 MED31 RBM47 SLC16A7 HSPA4 FBXL4	8.07e-06	989	80	14	ctd:D018120
Drug	CTK1E3650	C3 OPRD1	1.22e-05	2	80	2	CID011008728
Drug	4 A 3	ACSL4 ORC5 ACOX1 FBXL4	2.06e-05	46	80	4	CID000137566
Drug	AC1NDY3E	ACSL4 ACOX1 C3 SMPD2	2.65e-05	49	80	4	CID004633469
Disease	3-phenylpropionate hydrocinnamate measurement	LAMA1 TTC6	3.30e-04	10	81	2	EFO_0021010
Disease	amino acid measurement	ORC5 DNAH12 ACAD11 HHAT CHST11 RYR3 GABRA2 HAPLN1	5.49e-04	678	81	8	EFO_0005134
Disease	Cocaine Dependence	ICE2 ATP9B OPRD1 GABRA2	5.92e-04	139	81	4	C0600427
Disease	Antibody Deficiency Syndrome	C3 LEPR	9.85e-04	17	81	2	C0003257
Disease	longitudinal BMI measurement	HHAT RBM47 LEPR	1.51e-03	82	81	3	EFO_0005937
Disease	hepatocellular carcinoma (is_implicated_in)	TYMS POT1 LEPR RYR3	1.58e-03	181	81	4	DOID:684 (is_implicated_in)
Disease	Immunologic Deficiency Syndromes	C3 LEPR	1.81e-03	23	81	2	C0021051
Disease	colorectal cancer, hormone replacement therapy	LRPPRC SLC16A7 DISP1	1.85e-03	88	81	3	EFO_0003961, MONDO_0005575
Disease	Lewy body dementia, Lewy body dementia measurement	POT1 TTC6	2.32e-03	26	81	2	EFO_0006792, EFO_0006799
Disease	chronic obstructive pulmonary disease (is_marker_for)	C3 HSPA4 LEPR	2.44e-03	97	81	3	DOID:3083 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FKYNFPLVTLYATLG	ACSL4	171	O60488
TFYYAALKGVNVVPF	FAM210A	151	Q96ND0
GKSPLIVYFLQNYAS	FAM227A	426	F5H4B4
SYYYGKLVIAPLNIV	ALG9	271	Q9H6U8
LIQPGAVKVYAYYNL	C3	1471	P01024
GNFYLLYLLFHKVQP	ALG10B	106	Q5I7T1
VKNTGYKATLANYPF	DISP1	241	Q96F81
LYFLNIADEPVLGYN	ATG2B	1216	Q96BY7
IAQYRAGKSNPTFYL	ACAD11	46	Q709F0
YNALIGPNRDYFVKA	RBM47	361	A0AV96
SLYGALNPQYEFKEA	IRX6	96	P78412
SLGLYYLLLFKDPAQ	RADIL	346	Q96JH8
LQLYAPNFISAGYDL	CASKIN1	486	Q8WXD9
PASRNSGLYNITFKY	IL17RD	46	Q8NFM7
AVALAYGIYKQDLPA	HSPA4	176	P34932
IGYIYALLFVNKNFG	LANCL1	156	O43813
PKLFIYYASSLQSGV	IGKV1D-43	66	A0A0B4J1Z2
GDLFSISAYVYAQKP	ATP9B	291	O43861
PNYLNFLAQRGYFKD	MED31	31	Q9Y3C7
AYAVAVANYAPNLSK	GABRA2	366	P47869
TLVYGGIFLYPANQK	FBP2	256	O00757
AVGNIANKPTYFDIY	FLNB	366	O75369
LYSYGFLNARPLSVK	DNAH12	1391	Q6ZR08
FNLQPALTIIGKYFY	SLC16A7	126	O60669
NSTYDYFLLPAGLSK	LEPR	41	P48357
LQIIFSFSKAGYPQY	LRPPRC	306	P42704
LAAYTALKFYLQGPE	LAMA5	2756	O15230
PISRLYAKYFQGDLQ	PDK2	331	Q15119
PQLQYVDALGYVSLF	MOGS	681	Q13724
YAYAINPNSFILGLK	OASL	446	Q15646
LGYANSSLNPVLYAF	OPRD1	306	P41143
NPFIYSLRNRYLKGA	OR1F1	286	O43749
QLYKYNCPSFLAAAL	PPM1E	151	Q8WY54
GGLALAQVLFFYVKY	HHAT	286	Q5VTY9
FQYLRQKLSPTYPAA	SMPD2	56	O60906
TQQYKLFPLLATAYA	ACOX1	326	Q15067
GLRDVQPYLYKISFQ	ATG101	181	Q9BSB4
LLVDEALNPYYGFQA	ATP13A2	231	Q9NQ11
VGKLYNPDVRYSFNI	ADAMTS9	856	Q9P2N4
EYLAPQEGNFVYKLF	ICE2	721	Q659A1
AYLNKGQFYPVTLRT	GRHL3	251	Q8TE85
ENYLDLNLKGVFYPL	BPIFC	241	Q8NFQ6
NNGYFDKLPYELIQL	FBXL4	276	Q9UKA2
LPGVKNRFDLNTSYY	FRRS1	311	Q6ZNA5
YASKGIFVQSLIPFY	HSDL1	236	Q3SXM5
TLYPKRGFQCLQFYL	MEP1B	331	Q16820
SPFLLDYAQGAYGVK	CPHXL	276	A0A1W2PPM1
YLQNAFLVAYTKKAP	AFP	426	P02771
RLYQQIKAGAYDFPS	CAMK2D	221	Q13557
IDFSYLLYSQKGLNP	PTPRK	106	Q15262
NFNGRFYYLIHPTKL	HAPLN1	256	P10915
GVFLGSLQYPYHFQK	MS4A3	66	Q96HJ5
SNGFSDPYVKIYLLP	SYT3	331	Q9BQG1
NSKIGALLPYFVYVV	TAF6L	186	Q9Y6J9
YGPFYANILRKLLFN	TCP11L2	491	Q8N4U5
YVRNYLQKPTFALGE	LRRN3	661	Q9H3W5
YGALPFSVYSVLGNK	NKPD1	86	Q17RQ9
PYVAALYKQVGCFLF	PLPP3	121	O14495
GYIKIIPFYILNATN	TDRD12	881	Q587J7
AARFNLTYKALKPNY	OVCH2	411	Q7RTZ1
VLYFPDYSIGNLQKI	ORC5	176	O43913
SKFILIAAYLASYNP	ORC5	306	O43913
FYLGGLPSQYQARKI	LAMA1	2836	P25391
LFSGNYEALPIIYKN	POT1	61	Q9NUX5
YLISSIPLQGAFNYK	PIP	71	P12273
IPLQGAFNYKYTACL	PIP	76	P12273
INPVAFGALLQYLYT	ABTB1	161	Q969K4
QLAGVGSYLKFPTYA	CHST11	291	Q9NPF2
ILDLSFNYIKGSYPQ	TLR8	341	Q9NR97
PFILNAVTKNLGLYY	UBE3A	481	Q05086
INPAYIKARISFGYN	TTC6	276	Q86TZ1
TLNPKYSLAYFNAGN	TTC6	376	Q86TZ1
RFLVGYKNLVYLPTA	ZDHHC13	336	Q8IUH4
YAKEFGSSQQYLLPR	SSH2	1346	Q76I76
LSQLFYAIDNKYLPG	RYR3	1586	Q15413
LNVYLALYAYKPQKS	SH3RF3	466	Q8TEJ3
ILLNYAVYNPAVGYS	TBC1D16	516	Q8TBP0
LGVPFNIASYALLTY	TYMS	221	P04818
LAAYPYNFSNLAALP	ZBTB4	931	Q9P1Z0
FPYNQLCLAYKGFLA	PKHD1L1	741	Q86WI1
PKAYFRQGVALQYLG	TTC28	126	Q96AY4
KYSNFVSFPLYLNGR	TRAP1	276	Q12931
NASGKIEFYQDPLLY	VPS13B	216	Q7Z7G8
LNYLAEYLQPKAAEG	TGFBR3	206	Q03167
NVAAYLLNPFFAGLY	TMPPE	401	Q6ZT21
YTYAGSILVAINPFK	MYO9B	176	Q13459