Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionregulatory region RNA binding

IREB2 HNRNPA2B1

7.41e-055552GO:0001069
GeneOntologyMolecularFunctionactin binding

CYFIP1 MYL2 MYLK SYNE1 TRPV4 HCLS1 ADD1

3.28e-04479557GO:0003779
GeneOntologyMolecularFunctionactin filament binding

CYFIP1 SYNE1 TRPV4 HCLS1 ADD1

3.98e-04227555GO:0051015
MousePhenoabnormal muscle physiology

MYL2 MYLK RBL1 SYNE1 AGL AFG3L2 TRPV4 PARD3B NBEA CIT HYDIN

4.01e-059543911MP:0002106
DomainOxysterol-bd

OSBPL3 OSBPL6

5.32e-0412542IPR000648
DomainOxysterol-bd_CS

OSBPL3 OSBPL6

5.32e-0412542IPR018494
DomainOxysterol_BP

OSBPL3 OSBPL6

5.32e-0412542PF01237
DomainOSBP

OSBPL3 OSBPL6

5.32e-0412542PS01013
Pubmed

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.

PALD1 CHST11 GREB1 CSMD2 YES1 SMYD2

4.36e-0626556619240061
Pubmed

Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7.

OSBPL3 OSBPL6

7.63e-06356214593528
Pubmed

Proplatelet formation is regulated by the Rho/ROCK pathway.

MYL2 MYLK

7.63e-06356217244674
Pubmed

CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis.

MYLK HNRNPA2B1

7.63e-06356234588420
Pubmed

VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase.

RAB3GAP1 OSBPL3 OSBPL6

8.87e-062556324885147
Pubmed

Aurora B but not rho/MLCK signaling is required for localization of diphosphorylated myosin II regulatory light chain to the midzone in cytokinesis.

MYL2 MYLK

1.52e-05456223951055
Pubmed

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.

CYFIP1 CAND1 TRPV4 PARD3B YES1 ADD1

3.20e-0537756638117590
Pubmed

Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism.

OSBPL3 OSBPL6

3.80e-05656210588946
Pubmed

Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) promotes lung tumorigenesis via attenuating p53 stability.

DHX57 HNRNPA2B1

3.80e-05656229212181
Pubmed

Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress.

TRPV4 YES1

5.32e-05756212538589
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

CYFIP1 CAND1 SYNE1 NBEA CIT

5.32e-0525156527507650
Pubmed

RBR-type E3 ubiquitin ligase RNF144A targets PARP1 for ubiquitin-dependent degradation and regulates PARP inhibitor sensitivity in breast cancer cells.

CYFIP1 CAND1 ADD1

6.10e-054756329212245
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

RAB3GAP1 CYFIP1 CEP72 GCC2 KIF16B NBEA CSMD2

7.20e-0563856731182584
Pubmed

The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.

CYFIP1 CAND1 PLOD2 HNRNPA2B1

8.07e-0514156432322062
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

CYFIP1 CAND1 SYNE1 AFG3L2 OSBPL6 DHX57 NBEA CIT HNRNPA2B1 ADD1

8.53e-051431561037142655
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

CYFIP1 CAND1 SYNE1 NBEA CIT

9.06e-0528156528706196
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

PALD1 RAB3GAP1 OSBPL3 SYNE1 FDX1 AFG3L2 KIF16B DHX57 RMDN2 HNRNPA2B1

1.23e-041496561032877691
Pubmed

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

CYFIP1 RBL1 AFG3L2 HNRNPA2B1 ADD1

1.31e-0430456532235678
Pubmed

The OSBP-related protein family in humans.

OSBPL3 OSBPL6

1.39e-041156211483621
Pubmed

Loss-of-function variants in myocardin cause congenital megabladder in humans and mice.

MYL2 MYLK

1.39e-041156231513549
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

CYFIP1 CAND1 SLC4A8 OSBPL3 SYNE1 NBEA CIT ADD1

1.47e-0496356828671696
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

MYL2 RBL1 OSBPL3 SYNE1 IREB2 PARD3B CHST11

1.51e-0471956735337019
Pubmed

A family of 12 human genes containing oxysterol-binding domains.

OSBPL3 OSBPL6

1.66e-041256211735225
Pubmed

An oxysterol-binding protein family identified in the mouse.

OSBPL3 OSBPL6

1.66e-041256212215260
Pubmed

Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.

GLT8D2 CAND1 YES1 PLOD2

1.81e-0417456432149426
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

SP100 RAB3GAP1 CYFIP1 CAND1 AGL PCYT2 IREB2 PLOD2 HNRNPA2B1

4.92e-04145556922863883
Pubmed

Genome-wide association study of intelligence: additive effects of novel brain expressed genes.

KIF16B CSMD2

5.24e-042156222449649
Pubmed

Co-adaptor driven assembly of a CUL3 E3 ligase complex.

CAND1 AGL

5.76e-042256235120648
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

CYFIP1 AFG3L2 PARD3B YES1 ADD1

5.84e-0442156536976175
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

CYFIP1 CAND1 AFG3L2 THOC2 YES1 CIT HNRNPA2B1 ADD1

8.23e-04124756827684187
Pubmed

Identification of proteins that interact with alpha A-crystallin using a human proteome microarray.

OSBPL3 PCYT2 HCLS1

9.26e-0411856324453475
Pubmed

Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications.

YES1 HCLS1

9.37e-042856218067320
Pubmed

HENA, heterogeneous network-based data set for Alzheimer's disease.

SYNE1 TNKS2 CCSER1

9.72e-0412056331413325
Pubmed

Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.

OSBPL3 AFG3L2 OSBPL6 PLOD2

1.13e-0328356418854154
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RAB3GAP1 SLC4A8 CEP72 OSBPL3 CCSER1

1.18e-0349356515368895
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

PALD1 CYFIP1 RBL1 OSBPL3 GCC2 AFG3L2 OSBPL6 SMYD2

1.19e-03132156827173435
Pubmed

NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.

CAND1 NBEA HCLS1

1.20e-0312956323022380
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

CYFIP1 AFG3L2 DHX57 NBEA HYDIN

1.22e-0349756536774506
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

CAND1 SYNE1 AFG3L2 THOC2 YES1 CIT HNRNPA2B1

1.24e-03102456724711643
Pubmed

Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis.

MYL2 YES1

1.30e-033356216870172
Pubmed

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

CEP112 GCC2 PLOD2 CIT

1.37e-0329856432353859
Pubmed

Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage.

AGBL2 HYDIN

1.46e-033556237890489
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

OSBPL3 AGL IREB2 DHX57 THOC2 PLOD2 HNRNPA2B1 ADD1

1.51e-03137156836244648
Cytoband7p15

OSBPL3 HNRNPA2B1

1.32e-04145627p15
GeneFamilyOxysterol binding proteins|Pleckstrin homology domain containing

OSBPL3 OSBPL6

1.98e-0412322670
CoexpressionGSE21033_CTRL_VS_POLYIC_STIM_DC_3H_DN

CEP72 SYNE1 PCYT2 CIT ADCY7 ADD1

4.20e-06199566M7711
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

RAB3GAP1 MYLK GCC2 AGL KIF16B PARD3B

1.26e-0718656603db813598b67b1e08f759758a1c2023396921fa
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

CEP112 SYNE1 OSBPL6 PARD3B NBEA HYDIN

1.66e-07195566fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

CEP112 SYNE1 OSBPL6 PARD3B NBEA HYDIN

1.66e-07195566eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PALD1 SP100 CYFIP1 ADCY7 HCLS1

4.75e-06196565e54c08f88779f9fd453a4f5b85aed1f460d8a1e1
ToppCellBronchial-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PLA2R1 SLC4A8 TRPV4 NBEA CCSER1

5.25e-0620056585c0f038bcfb42669dca2b80273b0f8a1421405e
ToppCellmild_COVID-19_(asymptomatic)-B_cell|World / disease group, cell group and cell class (v2)

MYLK CEP112 ZNF107 CCSER1

4.66e-05158564afa8fa21c39c2192c1e23a4660011d63d58b733f
ToppCellLeuk-UTI-Myeloid-cDC1|Leuk-UTI / Disease, Lineage and Cell Type

MYLK CEP112 OSBPL6 CCSER1

6.63e-05173564226bb8d881f32d65c60f5e4c034c6d465f8e7ba5
ToppCelldroplet-Lung-21m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MYL2 SLC4A8 SKA1 CIT

7.57e-051795644f20540bfbcefe0e83812be7ea542e8bb3bf19bc
ToppCellLymphoid-Lymphoid-T_cells_(cycle)|Lymphoid / shred on cell class and cell subclass (v4)

RBL1 DTYMK SKA1 CIT

7.90e-05181564b6b41cd5d43543fe7a093033dae52a789199db0e
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CHST11 ADCY7 HCLS1

8.25e-05183564a97f052950429245c3231464271e1ba539863bba
ToppCellfacs-Marrow-KLS-18m-Hematologic-MPP_Fraction_B|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CEP112 DTYMK FDX1 SMYD2

8.25e-05183564b60638680b1882b5a47f5dbce08f545e93bb4d0f
ToppCellCOVID-cycling-|COVID / Condition, Cell_class and T cell subcluster

PLA2R1 DTYMK SKA1 CIT

8.60e-05185564eb74b8d36f7b749e04bc2ed4b36f7e1ac7bb6d5f
ToppCellCOVID-cycling|COVID / Condition, Cell_class and T cell subcluster

PLA2R1 DTYMK SKA1 CIT

8.60e-051855645112f966735fa48f0606adcfd5c0212ad5d3d77a
ToppCellfacs-Skin-Telogen-3m-Epithelial-actively_dividing_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CEP72 AGBL2 SKA1 CIT

8.78e-051865649feef5936985e936b3d88f9d1bb012abb6468570
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CHST11 ADCY7 HCLS1

8.78e-05186564e152bdd837366e3e0b8bcfdb4d53f0685f2e803a
ToppCellfacs-Skin-Telogen-3m-Epithelial-keratinocyte_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CEP72 AGBL2 SKA1 CIT

8.78e-0518656489f5b06bc56674af304912d481ac697c7c870904
ToppCellCOPD-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

PALD1 MYLK SYNE1 OSBPL6

9.15e-051885641aa0e35b1c28ac847886fece16c3ef7fc6fcdd51
ToppCell3'_v3-Lung-Myeloid_Dendritic-Cycling_Dendritic|Lung / Manually curated celltypes from each tissue

PALD1 MYL2 DTYMK SKA1

9.15e-051885640e8ac42c439f30a05e015210e1d5c2dcb9d9d471
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

OSBPL6 CHST11 ADCY7 HCLS1

9.34e-051895647ccea2df93bb4b37417bbc8f6c85a61ece95211a
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

OSBPL3 SYNE1 PARD3B CCSER1

9.34e-05189564830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

OSBPL3 SYNE1 HYDIN CCSER1

9.53e-051905643fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

OSBPL6 CHST11 ADCY7 HCLS1

9.73e-05191564468b5149d1533f03521844d3cce8633d44eb6ed4
ToppCellPCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SLC4A8 SKA1 CIT CCSER1

9.92e-0519256425378b5e4b0cea8415ff125783511fc25a56fc00
ToppCellASK452-Immune-NK_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

SYNE1 AGL ZNF107 ADCY7

9.92e-05192564f04ee5aaa54c39b7493098fb3d2f78168d6b8060
ToppCell11.5-Airway-Mesenchymal-Cartilage|Airway / Age, Tissue, Lineage and Cell class

GLT8D2 TRPV4 CHST11 PLOD2

1.01e-04193564d4779d92a4dd4b8b656383e6f4fce76d3bd70931
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CHST11 ADCY7 HCLS1

1.01e-041935643e3d7cb3e7242ec9c9677e07e303835649852b52
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

CAND1 GCC2 IREB2 THOC2

1.01e-04193564abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellIPF-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

PALD1 MYLK SYNE1 OSBPL6

1.03e-04194564777ce41c3f22c591e2d81120f189b834e53ffb4b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CHST11 ADCY7 HCLS1

1.03e-04194564badefcec2af86cbcd97305f4843e84db0f3ebc66
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CHST11 ADCY7 HCLS1

1.03e-04194564c95d5c4ad0210ebd672926558cc8331e6396a854
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CHST11 ADCY7 HCLS1

1.07e-041965644370473693d2dd4a8c451a4c477eb79baa33ae12
ToppCellsevere-T/NK_proliferative|severe / disease stage, cell group and cell class

CEP72 DTYMK SKA1 CIT

1.07e-0419656489f005216770dbb84378f5d1f20ca11b0ce40faa
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CHST11 ADCY7 HCLS1

1.07e-04196564291c59b609985167c98a40d4e2caeea2fad74941
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CHST11 ADCY7 HCLS1

1.07e-04196564cbc727b55b6433a701b1a331028a49960fcee6ee
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CHST11 ADCY7 HCLS1

1.10e-041975646ca6e17b7cc5f7ea8d4b6ca1ff670969bee65a45
ToppCellCOVID-19-Fibroblasts-Intermediate_pathological_FB|COVID-19 / group, cell type (main and fine annotations)

PLA2R1 MYLK CSMD2 PLOD2

1.10e-04197564f1c8936986123a3151140c374fcd62d6705c530b
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

OSBPL3 SYNE1 OSBPL6 HYDIN

1.10e-0419756474a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CHST11 ADCY7 HCLS1

1.10e-04197564d95565652ca318a2298d6918d54ba6367e9560f4
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CHST11 ADCY7 HCLS1

1.10e-04197564dea1d29154c585ab588e50b83c7c8de7fe24d2d4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CHST11 ADCY7 HCLS1

1.10e-0419756457dafb3047745a44b2345b8036e159c3641d496e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CHST11 ADCY7 HCLS1

1.10e-04197564826cc6baafab13e7ef5cfcf28cd79d0fbf3af38d
ToppCellCOVID-19-Fibroblasts|COVID-19 / group, cell type (main and fine annotations)

MYLK PARD3B CSMD2 PLOD2

1.10e-04197564fb847f2277609c31fffcdf49517243ce0684facf
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CHST11 ADCY7 HCLS1

1.10e-0419756472cd61b868d57862ec9c230ea68913d3829b0f2b
ToppCellsystemic_lupus_erythematosus-flare|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SP100 GCC2 SYNE1 HNRNPA2B1

1.12e-041985644c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNE1 OSBPL6 NBEA CCSER1

1.12e-04198564c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNE1 OSBPL6 NBEA CCSER1

1.12e-041985648ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNE1 OSBPL6 NBEA CCSER1

1.12e-041985644ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PALD1 CYFIP1 ADCY7 HCLS1

1.12e-04198564cc808d872d2404a79ec119bb0be62688a30c93a7
ToppCellCOVID-19_Severe-Neu_4|COVID-19_Severe / 5 Neutrophil clusters in COVID-19 patients

CAND1 RBL1 SKA1 CIT

1.12e-04198564bfdddddef9f3f0eb6af013873dec4e06b7c78c58
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CHST11 ADCY7 HCLS1

1.14e-0419956404adf46975aa4194ea40c7480f8a517def5d929c
ToppCellCOVID-19_Severe-Neu_4|World / 5 Neutrophil clusters in COVID-19 patients

CAND1 RBL1 SKA1 CIT

1.14e-041995640e327479bbda5a16643cf317d293a2918d619f87
ToppCellCOVID-19_Severe-immature_Neutrophil|COVID-19_Severe / Disease condition and Cell class

SYNE1 AGL SKA1 CIT

1.14e-04199564f82fa9d651e78f9ebbe6264e00a48c54b1786a69
ToppCellCOVID-19_Moderate|World / disease group, cell group and cell class

SP100 GCC2 SYNE1 ZNF107

1.14e-04199564952fac67588ad5676f5939e3c7f8bac803c27064
ToppCellCOVID-19_Severe-immature_Neutrophil-|COVID-19_Severe / Disease condition and Cell class

SYNE1 AGL SKA1 CIT

1.14e-0419956442ea0c19c455bdb0ae89b428d09c333104c670dc
ToppCellTransverse-B_cell-B_cell_cycling|B_cell / Region, Cell class and subclass

RBL1 ZNF107 SKA1 CIT

1.14e-04199564170ae68963d31f3b821b6f0e8f0c039bea0bc981
ToppCellTracheal-NucSeq-Immune_Myeloid|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PALD1 CHST11 ADCY7 HCLS1

1.16e-04200564ad7ae5106141669b353800fece833b3cd5bdccee
ToppCellTracheal|World / Cell types per location group and 10X technology with lineage, and cell group designations

PLA2R1 TRPV4 NBEA CCSER1

1.16e-04200564682960e28542a3d6c119047cd0131941932cfdea
ToppCellTransverse-(2)_B_cell-(24)_B_cell_cycling|Transverse / shred on region, Cell_type, and subtype

RBL1 ZNF107 SKA1 CIT

1.16e-04200564e3f9736227151f23f0e331eec0a7a15ce464b517
ToppCellTransverse-B_cell-B_cell_cycling|Transverse / Region, Cell class and subclass

RBL1 ZNF107 SKA1 CIT

1.16e-042005640e270f8019d9f22068ca426d661937262a5cd331
ToppCellTracheal-NucSeq-Immune_Myeloid-Monocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PALD1 CHST11 ADCY7 HCLS1

1.16e-0420056448ce43a27e78b2883e588e1a63fa5352c2deeeb7
ToppCellSepsis-Leuk-UTI-Myeloid-cDC1|Leuk-UTI / Disease, condition lineage and cell class

MYLK CEP112 OSBPL6 CCSER1

1.16e-04200564186852d54eced4c036876cc891773605068b56b5
ToppCellSepsis-URO-Myeloid-cDC1|URO / Disease, condition lineage and cell class

PALD1 MYLK KIF16B CCSER1

1.16e-04200564c5ca81218be40b30e2f9252c1a004cb95d988447
ToppCell367C-Epithelial_cells-Epithelial-B_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PALD1 CEP72 CCSER1

2.48e-0497563eab10b1af9cd0ce373cd4d0316e0d7b218630584
ToppCell367C-Epithelial_cells-Epithelial-B_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PALD1 CEP72 CCSER1

2.48e-049756304f571708f2487b0dbd70ee507de6bf75be5f5d9
ToppCellfacs-Heart-RV-18m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYL2 CIT HYDIN

6.38e-04134563d101e16cb87ff72c81324406fe7e3d70ed8f45df
ToppCellfacs-Heart-RV-18m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYL2 CIT HYDIN

6.38e-041345630c63c8b3c748d29c59fcb27d03276ba4f6a0d6b2
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SP100 OSBPL3 HCLS1

7.70e-04143563138033ff447a61a1bc289b21db82151dcc6a4c7e
ToppCellTCGA-Thymus-Primary_Tumor-Thymoma-Type_AB-8|TCGA-Thymus / Sample_Type by Project: Shred V9

PLA2R1 GLT8D2 MYLK

9.02e-041515635906562efd36fbcb91f96e0a0d3a8fe999ba1e79
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SP100 OSBPL3 HCLS1

9.19e-04152563ed6df77ba04b715e12c2e1591b4a1e894ca49d25
ToppCell343B-Lymphocytic-NK_cells-NK_cell_B0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CYP2C18 OSBPL6 SKA1

9.72e-04155563583cfaa41c755c63aee312eb442e9d97f645d5f7
ToppCell10x5'-Liver-Myeloid_Mac-Intestinal_macrophages|Liver / Manually curated celltypes from each tissue

PALD1 TRPV4 PARD3B

9.91e-041565639a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PLA2R1 CEP112 OSBPL6

1.05e-03159563b05fda31b77536a1878f55d3199563b53f9420b2
ToppCellICU-SEP-Myeloid-cDC1|ICU-SEP / Disease, Lineage and Cell Type

MYLK KIF16B CCSER1

1.08e-031615639fb73909fc2ec99f96ca2eed1a053bce89de7d16
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TRPV4 NBEA AGBL2

1.08e-031615639703b7e67d9fadb6129cad166bd01be915042e44
ToppCellfacs-Pancreas-Exocrine-18m-Hematologic-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP100 ADCY7 HCLS1

1.08e-0316156316f77e7a5444d2f2b210362816cd7a07b9b42af6
ToppCellfacs-Pancreas-Exocrine-18m-Hematologic|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP100 ADCY7 HCLS1

1.08e-03161563f5821f551cf5c64c9f75cdb723492c87aac1ece0
ToppCell10x5'-bone_marrow-Myeloid_Dendritic-DC1|bone_marrow / Manually curated celltypes from each tissue

KIF16B HYDIN CCSER1

1.08e-031615632f068ee643de2f647c289779a6624265ab9a749b
ToppCellfacs-Pancreas-Exocrine-18m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP100 ADCY7 HCLS1

1.08e-0316156358a32a1033f379579697bda1bbf047a088e4a34f
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RBL1 RMDN2 ADCY7

1.12e-03163563d2fcd6f561748f7d29a051c504f016952ba32d0f
ToppCellInt-URO-Myeloid-cDC1|Int-URO / Disease, Lineage and Cell Type

MYLK KIF16B CCSER1

1.14e-03164563f4628a7ff0dc765a5337ab499b3d61fc25573a16
ToppCellICU-SEP-Lymphocyte-T_NK-MAIT|ICU-SEP / Disease, Lineage and Cell Type

CEP72 USP27X ZNF354B

1.14e-03164563db863a44fc0dad5518c47fdbf64ea21d6f36f089
ToppCelldroplet-Lung-nan-3m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A8 CEP72 CHST11

1.14e-0316456378de403446fe0eb375c82ff1832cc5fbb8e20afa
ToppCelldroplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC4A8 CEP72 CHST11

1.16e-03165563c39f0479955c4e23921f7a450d3bc251a002200f
ToppCell356C-Fibroblasts-Fibroblast-D|356C / Donor, Lineage, Cell class and subclass (all cells)

PLA2R1 GLT8D2 CEP112

1.18e-031665637286a37b2827f3747469ffd0d76cbe81116db7ee
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SP100 CEP72 CIT

1.18e-03166563a41a20cef053c67da2d435e3e132ce28f1661c03
ToppCell356C-Fibroblasts-Fibroblast-D-|356C / Donor, Lineage, Cell class and subclass (all cells)

PLA2R1 GLT8D2 CEP112

1.18e-031665637c2eee0a4f45795a956acf936b85bdb35f1b1624
ToppCell10x5'-Lung-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|Lung / Manually curated celltypes from each tissue

DTYMK GREB1 SKA1

1.21e-0316756382739226347d74897be000f429b73543a031af96
ToppCell10x5'-Lung-Hematopoietic_progenitors|Lung / Manually curated celltypes from each tissue

DTYMK GREB1 SKA1

1.21e-03167563dec18caf0475002d4ad3c7bc7fc3050cbc8e6bae
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SP100 OSBPL3 HCLS1

1.21e-0316756384551ee71f9d8d03d514711fc7ca4422c810140b
ToppCellControl|World / group, cell type (main and fine annotations)

SYNE1 PARD3B CCSER1

1.23e-03168563a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SKA1 CIT HCLS1

1.23e-0316856352fd65024af8683db11d931f7563cbe8eb815d1c
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CHST11 ADCY7

1.25e-03169563b2fdf9f842dc7c181bc951a8a6932c916ed835ef
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CHST11 ADCY7

1.25e-031695632322f03a115c662f808ebfc892192b7d38d48181
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NBEA AGBL2 HYDIN

1.25e-0316956314aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell390C-Lymphocytic-NK_cells-Proliferating_NK_cell|390C / Donor, Lineage, Cell class and subclass (all cells)

DTYMK SKA1 CIT

1.27e-031705635319f73cff64f2bb67472c7156ee1d0f006c6fc0
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-10|TCGA-Brain / Sample_Type by Project: Shred V9

MYLK CEP112 KIF16B

1.29e-0317156374be8d3bf6b99e2d734635a8b1a7c41e8c596959
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

OSBPL3 AGBL2 HYDIN

1.29e-031715631854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCellmild_COVID-19_(asymptomatic)-RBC|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

RBL1 PCYT2 CCSER1

1.29e-0317156378491478ba65bad45238fe114f5251b2adea323d
ToppCell356C-Myeloid-Dendritic-cDC_proliferating_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CEP112 OSBPL6 SKA1

1.29e-03171563b113fbebb89056af0b9c775d2fb6552206a80467
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RBL1 YES1 CIT

1.31e-031725632b6cd84c946b1e800caba452ae70145ea285fec1
Diseaseanemia (implicated_via_orthology)

SLC4A8 IREB2

3.66e-0415562DOID:2355 (implicated_via_orthology)
Diseasehydrocephalus (implicated_via_orthology)

HYDIN ADD1

5.93e-0419562DOID:10908 (implicated_via_orthology)
Diseasetemporal lobe epilepsy (biomarker_via_orthology)

CYFIP1 ADD1

1.59e-0331562DOID:3328 (biomarker_via_orthology)
Diseaseoxalate measurement

MYLK RMDN2

1.69e-0332562EFO_0010517

Protein segments in the cluster

PeptideGeneStartEntry
ENSVIKELDKYLQHH

FAM228B

51

P0C875
VELHLAGTYKKEDFH

CSMD2

3316

Q7Z408
EEKKTVAYHEAGHAV

AFG3L2

566

Q9Y4W6
HLIFEDHIYEKLDAI

FDX1

116

P10109
TLHKEKDHLVNDYEQ

CEP112

461

Q8N8E3
FYEQHKAIAEHVKGI

CCSER1

396

Q9C0I3
GEIVELKQHLEHYDK

CEP72

566

Q9P209
LKHLDKAYEVEDGHG

ADCY7

421

P51828
EVHLKQKEQHYEEKI

CIT

711

O14578
QKIYEVDGVQKDHHG

KIF16B

1076

Q96L93
HHYLVQESTDKEGKD

RAB3GAP1

76

Q15042
LAESYEKIHKDHLIG

IREB2

871

P48200
IHGEDDLHVTEEVYK

PALD1

241

Q9ULE6
DYKNLVHIITHGEEK

MYL2

151

P10916
FHHQLKDIVEYAELK

CYFIP1

976

Q7L576
YHLLKVQKHDGKDEI

CYFIP1

1181

Q7L576
DGHLEIVKYLVEHKA

FEM1C

126

Q96JP0
VKIHHLEYTDGGILD

PARD3B

46

Q8TEW8
EGVEYIHKQGIVHLD

MYLK

1571

Q15746
FGIHLKEIDKEEHLY

MAGED4

466

Q96JG8
DGASHLHVLVVKEYE

GREB1

1566

Q4ZG55
LNHVEDGLKDHYDIK

CAND1

1106

Q86VP6
YLIVGVHTDEEIAKH

PCYT2

51

Q99447
IHQHEKVIYLDDDVI

GLT8D2

146

Q9H1C3
DLDTEEHIYHLKVKS

OSBPL6

151

Q9BZF3
EALKLFIHNKEVYHE

PLOD2

326

O00469
ENTEGLHHLYEIIKG

PPP4R3C

186

Q6ZMV5
KDIHYGLQLFDHVTE

HYDIN

1391

Q4G0P3
ELKFVTKNDGYVHIH

DHX57

1251

Q6P158
AHKELEQSHINYVKE

GCC2

116

Q8IWJ2
QEIHKKFHELGQDVD

AGBL2

686

Q5U5Z8
VLHGYEAVKEALIDH

CYP2C18

76

P33260
DLDTEEHIYHLKVKS

OSBPL3

116

Q9H4L5
YKDIEHLKENVPSHL

SKA1

81

Q96BD8
LLDKHKEYFQGLESH

SYNE1

6626

Q8NF91
KSAVGHEYVAEVEKH

HCLS1

96

P14317
HDGLLVEAKGIKEHY

RBL1

256

P28749
LAEHHKQVLYDGKLA

NBEA

426

Q8NFP9
KINYGHLFKEHLDIA

RMDN2

281

Q96LZ7
TILNIHYEKEELEGH

SLC4A8

31

Q2Y0W8
KYLNHIDHEIVEKDA

PLA2R1

356

Q13018
HDYHGILVDEEEKVL

ADD1

271

P35611
DLKHLVVDEDHELIY

CHST11

106

Q9NPF2
LALHEKTHNEEKPYI

ZNF567

436

Q8N184
KIIHTGENLYKFEEH

ZNF107

571

Q9UII5
LFYHKQVLEHESEKV

USP27X

416

A6NNY8
ELSYHVIKGNLKHEQ

THOC2

51

Q8NI27
DDHDPVDKIVLQKYH

HNRNPA2B1

161

P22626
DLIHIYKGFENVIHD

SP100

136

P23497
VVEYLLQHGADVHAK

TNKS2

541

Q9H2K2
HELEEQVKKLSHDTY

SPZ1

301

Q9BXG8
HYKIHIEEDSLKADL

ZNF354B

596

Q96LW1
HGKDHPYISEIKQEI

SMYD2

416

Q9NRG4
KHYVELLVAQGADVH

TRPV4

251

Q9HBA0
DTLQKLVKHYTEHAD

YES1

231

P07947
YKEKGIPALIENDHH

AGL

266

P35573
YLQKKSDVEDHSVHL

DTYMK

56

P23919