Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC41A2 SLC22A18 SLC7A4 ABCA3 SLC9A5 DCD SCN3A SCN4A ABCB6 KCNK6 ASIC4 PKD1L2 ABCA7 SLC16A8 CACNA2D3 SLC22A31	1.28e-06	1180	67	16	GO:0022857
GeneOntologyMolecularFunction	transporter activity	SLC41A2 SLC22A18 SLC7A4 ABCA3 SLC9A5 DCD SCN3A SCN4A ABCB6 KCNK6 ASIC4 PKD1L2 ABCA7 SLC16A8 CACNA2D3 SLC22A31	4.04e-06	1289	67	16	GO:0005215
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC41A2 SLC9A5 SCN3A SCN4A KCNK6 ASIC4 PKD1L2 CACNA2D3	1.59e-04	465	67	8	GO:0046873
GeneOntologyMolecularFunction	complement component C1q complex binding	C4A C4B	4.91e-04	10	67	2	GO:0001849
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCA3 ABCB6 ABCA7	5.96e-04	49	67	3	GO:0140359
GeneOntologyMolecularFunction	sodium channel activity	SCN3A SCN4A ASIC4	7.09e-04	52	67	3	GO:0005272
GeneOntologyMolecularFunction	hexosyltransferase activity	B3GNT9 UGT8 POMT1 CHPF PIGZ	7.13e-04	211	67	5	GO:0016758
GeneOntologyMolecularFunction	monoatomic ion channel activity	DCD SCN3A SCN4A KCNK6 ASIC4 PKD1L2 CACNA2D3	8.58e-04	459	67	7	GO:0005216
GeneOntologyMolecularFunction	monoatomic cation channel activity	SCN3A SCN4A KCNK6 ASIC4 PKD1L2 CACNA2D3	1.02e-03	343	67	6	GO:0005261
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC41A2 SLC9A5 SCN3A SCN4A KCNK6 ASIC4 PKD1L2 CACNA2D3	1.15e-03	627	67	8	GO:0022890
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC41A2 SLC9A5 DCD SCN3A SCN4A KCNK6 ASIC4 PKD1L2 CACNA2D3	1.27e-03	793	67	9	GO:0015075
GeneOntologyMolecularFunction	bioactive lipid receptor activity	S1PR5 GPR31	1.29e-03	16	67	2	GO:0045125
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	IL10RA S1PR5 ADRB3 OR56B1 GPR31 OR10AC1 OR1K1 FGFR4 CHRM1 PTGIR ABCA7 CXCR2	1.65e-03	1353	67	12	GO:0004888
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC41A2 SLC9A5 SCN3A SCN4A KCNK6 ASIC4 PKD1L2 CACNA2D3	1.66e-03	664	67	8	GO:0008324
GeneOntologyMolecularFunction	channel activity	DCD SCN3A SCN4A KCNK6 ASIC4 PKD1L2 CACNA2D3	1.86e-03	525	67	7	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	DCD SCN3A SCN4A KCNK6 ASIC4 PKD1L2 CACNA2D3	1.88e-03	526	67	7	GO:0022803
GeneOntologyMolecularFunction	phosphatidylcholine transporter activity	ABCA3 ABCA7	2.03e-03	20	67	2	GO:0008525
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC9A5 SCN3A SCN4A ASIC4	2.62e-03	171	67	4	GO:0015081
GeneOntologyMolecularFunction	G protein-coupled receptor activity	S1PR5 ADRB3 OR56B1 GPR31 OR10AC1 OR1K1 CHRM1 PTGIR CXCR2	2.68e-03	884	67	9	GO:0004930
GeneOntologyMolecularFunction	glycosyltransferase activity	B3GNT9 UGT8 POMT1 CHPF PIGZ	2.81e-03	288	67	5	GO:0016757
GeneOntologyMolecularFunction	opsonin binding	C4A C4B	3.17e-03	25	67	2	GO:0001846
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN3A SCN4A	3.42e-03	26	67	2	GO:0005248
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC41A2 SLC9A5 SCN3A SCN4A KCNK6 ASIC4 PKD1L2 CACNA2D3	3.75e-03	758	67	8	GO:0015318
GeneOntologyMolecularFunction	mannosyltransferase activity	POMT1 PIGZ	3.96e-03	28	67	2	GO:0000030
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ABCA3 ABCA7	3.96e-03	28	67	2	GO:0140326
GeneOntologyMolecularFunction	complement binding	C4A C4B	5.16e-03	32	67	2	GO:0001848
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC22A18 ABCA3 SLC9A5 ABCB6 ABCA7 SLC16A8	5.25e-03	477	67	6	GO:0022804
GeneOntologyMolecularFunction	xenobiotic transmembrane transporter activity	SLC22A18 ABCA3	5.81e-03	34	67	2	GO:0042910
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCA3 ABCB6 ABCA7	5.88e-03	109	67	3	GO:0042626
GeneOntologyBiologicalProcess	positive regulation of apoptotic cell clearance	C4A C4B ABCA7	1.90e-06	8	68	3	GO:2000427
GeneOntologyBiologicalProcess	regulation of apoptotic cell clearance	C4A C4B ABCA7	4.05e-06	10	68	3	GO:2000425
GeneOntologyBiologicalProcess	monoatomic ion transport	SLC41A2 SLC22A18 SLC9A5 DCD SCN3A SCN4A ABCB6 KCNK6 LACRT ASIC4 PKD1L2 STEAP2 CHRM1 CACNA2D3 SLC22A31	3.24e-05	1374	68	15	GO:0006811
GeneOntologyBiologicalProcess	regulation of phospholipid efflux	ABCA3 ABCA7	6.40e-05	4	68	2	GO:1902994
GeneOntologyBiologicalProcess	positive regulation of phospholipid efflux	ABCA3 ABCA7	6.40e-05	4	68	2	GO:1902995
GeneOntologyBiologicalProcess	glycolipid biosynthetic process	GPAA1 UGT8 PIGG PIGZ	1.48e-04	81	68	4	GO:0009247
GeneOntologyBiologicalProcess	membrane lipid biosynthetic process	GPAA1 UGT8 PIGG PIGZ CERS4	1.70e-04	157	68	5	GO:0046467
GeneOntologyBiologicalProcess	GPI anchor biosynthetic process	GPAA1 PIGG PIGZ	1.74e-04	33	68	3	GO:0006506
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	SLC41A2 SLC9A5 SCN3A SCN4A ABCB6 KCNK6 LACRT ASIC4 PKD1L2 STEAP2 CACNA2D3	1.99e-04	922	68	11	GO:0098662
GeneOntologyBiologicalProcess	GPI anchor metabolic process	GPAA1 PIGG PIGZ	2.08e-04	35	68	3	GO:0006505
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	SLC41A2 SLC9A5 SCN3A SCN4A ABCB6 KCNK6 LACRT ASIC4 PKD1L2 STEAP2 CACNA2D3	2.40e-04	942	68	11	GO:0098655
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	SLC41A2 SLC9A5 DCD SCN3A SCN4A ABCB6 KCNK6 LACRT ASIC4 PKD1L2 STEAP2 CACNA2D3	2.58e-04	1115	68	12	GO:0034220
GeneOntologyBiologicalProcess	positive regulation of lipid transport	ERFE ABCA3 C1QTNF1 ABCA7	3.60e-04	102	68	4	GO:0032370
GeneOntologyBiologicalProcess	metal ion transport	SLC41A2 SLC9A5 SCN3A SCN4A ABCB6 KCNK6 LACRT ASIC4 PKD1L2 STEAP2 CACNA2D3	3.99e-04	1000	68	11	GO:0030001
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	SLC41A2 SLC9A5 SCN3A SCN4A ABCB6 KCNK6 LACRT ASIC4 PKD1L2 STEAP2 CACNA2D3	4.60e-04	1017	68	11	GO:0098660
GeneOntologyBiologicalProcess	apoptotic cell clearance	C4A C4B ABCA7	5.33e-04	48	68	3	GO:0043277
GeneOntologyBiologicalProcess	glycolipid metabolic process	GPAA1 UGT8 PIGG PIGZ	6.45e-04	119	68	4	GO:0006664
GeneOntologyBiologicalProcess	liposaccharide metabolic process	GPAA1 UGT8 PIGG PIGZ	6.66e-04	120	68	4	GO:1903509
GeneOntologyBiologicalProcess	carbohydrate derivative biosynthetic process	B3GNT9 GPAA1 CHST6 UGT8 PIGG POMT1 CHPF PIGZ ABCA7	6.69e-04	736	68	9	GO:1901137
GeneOntologyCellularComponent	symbiont cell surface	C4A C4B	2.88e-04	8	68	2	GO:0106139
GeneOntologyCellularComponent	other organism part	C4A C4B	3.70e-04	9	68	2	GO:0044217
HumanPheno	Muscle spasm	CCNF PHKA2 SH3TC2 SCN4A ABCB6 PIGG POMT1	6.18e-06	178	22	7	HP:0003394
Domain	Anaphylatoxin_comp_syst	C4A C4B	1.22e-04	5	66	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	1.22e-04	5	66	2	IPR001840
Domain	ANATO	C4A C4B	2.55e-04	7	66	2	SM00104
Domain	ANATO	C4A C4B	2.55e-04	7	66	2	PF01821
Domain	ANAPHYLATOXIN_2	C4A C4B	2.55e-04	7	66	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	2.55e-04	7	66	2	PS01177
Domain	Anaphylatoxin/fibulin	C4A C4B	2.55e-04	7	66	2	IPR000020
Domain	Thiol-ester_cl	C4A C4B	3.40e-04	8	66	2	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	3.40e-04	8	66	2	IPR019565
Domain	MacrogloblnA2_CS	C4A C4B	3.40e-04	8	66	2	IPR019742
Domain	ABC_transporter_CS	ABCA3 ABCB6 ABCA7	4.38e-04	42	66	3	IPR017871
Domain	Na_channel_asu	SCN3A SCN4A	5.43e-04	10	66	2	IPR001696
Domain	A2M_N	C4A C4B	5.43e-04	10	66	2	PF01835
Domain	A2M_N	C4A C4B	5.43e-04	10	66	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	5.43e-04	10	66	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	5.43e-04	10	66	2	PS00477
Domain	A2M	C4A C4B	5.43e-04	10	66	2	PF00207
Domain	Na_trans_assoc	SCN3A SCN4A	5.43e-04	10	66	2	IPR010526
Domain	A2M_N_2	C4A C4B	5.43e-04	10	66	2	IPR011625
Domain	A2M_comp	C4A C4B	5.43e-04	10	66	2	IPR011626
Domain	A2M_N_2	C4A C4B	5.43e-04	10	66	2	PF07703
Domain	A2M_recep	C4A C4B	5.43e-04	10	66	2	PF07677
Domain	A2M_comp	C4A C4B	5.43e-04	10	66	2	PF07678
Domain	Macroglobln_a2	C4A C4B	5.43e-04	10	66	2	IPR001599
Domain	Na_trans_assoc	SCN3A SCN4A	5.43e-04	10	66	2	PF06512
Domain	ABC_tran	ABCA3 ABCB6 ABCA7	6.51e-04	48	66	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCA3 ABCB6 ABCA7	6.51e-04	48	66	3	PS50893
Domain	ABC_TRANSPORTER_1	ABCA3 ABCB6 ABCA7	6.91e-04	49	66	3	PS00211
Domain	ABC_transporter-like	ABCA3 ABCB6 ABCA7	7.34e-04	50	66	3	IPR003439
Domain	ABC_A	ABCA3 ABCA7	7.93e-04	12	66	2	IPR026082
Domain	C345C	C4A C4B	1.62e-03	17	66	2	SM00643
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	1.81e-03	18	66	2	IPR008930
Domain	NTR	C4A C4B	2.02e-03	19	66	2	PF01759
Domain	Netrin_module_non-TIMP	C4A C4B	2.02e-03	19	66	2	IPR018933
Domain	GPCR_Rhodpsn_7TM	S1PR5 ADRB3 OR56B1 GPR31 OR1K1 CHRM1 PTGIR CXCR2	2.41e-03	670	66	8	IPR017452
Domain	7tm_1	S1PR5 ADRB3 OR56B1 GPR31 OR1K1 CHRM1 PTGIR CXCR2	2.57e-03	677	66	8	PF00001
Domain	G_PROTEIN_RECEP_F1_1	S1PR5 ADRB3 OR56B1 GPR31 OR1K1 CHRM1 PTGIR CXCR2	2.76e-03	685	66	8	PS00237
Domain	G_PROTEIN_RECEP_F1_2	S1PR5 ADRB3 OR56B1 GPR31 OR1K1 CHRM1 PTGIR CXCR2	2.92e-03	691	66	8	PS50262
Domain	GPCR_Rhodpsn	S1PR5 ADRB3 OR56B1 GPR31 OR1K1 CHRM1 PTGIR CXCR2	2.94e-03	692	66	8	IPR000276
Domain	NTR	C4A C4B	2.97e-03	23	66	2	PS50189
Domain	Netrin_domain	C4A C4B	2.97e-03	23	66	2	IPR001134
Domain	TIMP-like_OB-fold	C4A C4B	3.78e-03	26	66	2	IPR008993
Domain	C1q_dom	ERFE C1QTNF1	6.41e-03	34	66	2	IPR001073
Domain	C1Q	ERFE C1QTNF1	6.41e-03	34	66	2	PS50871
Domain	MFS	SLC22A18 SLC16A8 SLC22A31	6.61e-03	108	66	3	PS50850
Pathway	KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS	GPAA1 PIGG PIGZ	9.70e-05	25	51	3	M13265
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC41A2 SLC22A18 ESYT2 ABCA3 LMF2 SLC9A5 ABCB6 ASIC4 ABCA7 SLC16A8	1.37e-04	681	51	10	MM14985
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC41A2 SLC22A18 ESYT2 ABCA3 LMF2 SLC9A5 ABCB6 ASIC4 ABCA7 SLC16A8	2.58e-04	736	51	10	M27287
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	2.66e-04	7	51	2	MM14685
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	3.54e-04	8	51	2	M27031
Pathway	KEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	3.54e-04	8	51	2	M47872
Pathway	KEGG_ABC_TRANSPORTERS	ABCA3 ABCB6 ABCA7	5.32e-04	44	51	3	M11911
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	6.91e-04	11	51	2	MM1430
Pathway	KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	6.91e-04	11	51	2	M47874
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	8.28e-04	12	51	2	MM1368
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	9.76e-04	13	51	2	M4732
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	S1PR5 ADRB3 GPR31 CHRM1 PTGIR CXCR2	1.17e-03	330	51	6	M18334
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	S1PR5 ADRB3 GPR31 CHRM1 PTGIR CXCR2	1.22e-03	333	51	6	MM14963
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	1.31e-03	15	51	2	M7146
Pathway	WP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY	C4A C4B	1.69e-03	17	51	2	MM15944
Pathway	REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI	PIGG PIGZ	1.69e-03	17	51	2	MM14621
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	1.69e-03	17	51	2	MM1369
Pathway	REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS	ABCA3 ABCA7	1.69e-03	17	51	2	MM14552
Pathway	REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI	PIGG PIGZ	1.89e-03	18	51	2	M1093
Pathway	REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS	ABCA3 ABCA7	1.89e-03	18	51	2	M524
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	MYADM B3GNT9 LMF2 GPAA1 BCAP29 TFPI2 VASN UGT8 C4A PIGG FGFR4 POMT1 CHPF PPP6R2 ABCA7	8.66e-09	1201	68	15	35696571
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	3.77e-06	2	68	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	3.77e-06	2	68	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	3.77e-06	2	68	2	15998580
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	3.77e-06	2	68	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	3.77e-06	2	68	2	17728371
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	3.77e-06	2	68	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	3.77e-06	2	68	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	3.77e-06	2	68	2	3696167
Pubmed	Structure and organization of the C4 genes.	C4A C4B	3.77e-06	2	68	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	3.77e-06	2	68	2	6149581
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	3.77e-06	2	68	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	3.77e-06	2	68	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	3.77e-06	2	68	2	19933335
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	3.77e-06	2	68	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	3.77e-06	2	68	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	3.77e-06	2	68	2	2387317
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	3.77e-06	2	68	2	8132550
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	3.77e-06	2	68	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	3.77e-06	2	68	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	3.77e-06	2	68	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	3.77e-06	2	68	2	12207352
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	3.77e-06	2	68	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	3.77e-06	2	68	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	3.77e-06	2	68	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	3.77e-06	2	68	2	6167582
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	3.77e-06	2	68	2	16908004
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	3.77e-06	2	68	2	30026462
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	3.77e-06	2	68	2	1438267
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	3.77e-06	2	68	2	7365238
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	3.77e-06	2	68	2	6559257
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	3.77e-06	2	68	2	27758680
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	3.77e-06	2	68	2	19150565
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	3.77e-06	2	68	2	7391573
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	3.77e-06	2	68	2	17506029
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	3.77e-06	2	68	2	22387014
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	3.77e-06	2	68	2	17971360
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	3.77e-06	2	68	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	3.77e-06	2	68	2	20506482
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	3.77e-06	2	68	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	3.77e-06	2	68	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	3.77e-06	2	68	2	2993295
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	3.77e-06	2	68	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	3.77e-06	2	68	2	17971229
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	3.77e-06	2	68	2	12480675
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	3.77e-06	2	68	2	6881182
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	3.77e-06	2	68	2	26800705
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	3.77e-06	2	68	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	3.77e-06	2	68	2	23918728
Pubmed	Identification of the site of sulfation of the fourth component of human complement.	C4A C4B	3.77e-06	2	68	2	3944109
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	3.77e-06	2	68	2	15390104
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	3.77e-06	2	68	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	3.77e-06	2	68	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	3.77e-06	2	68	2	4216347
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	3.77e-06	2	68	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	3.77e-06	2	68	2	21880985
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	3.77e-06	2	68	2	1699796
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	3.77e-06	2	68	2	6978711
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	3.77e-06	2	68	2	6950384
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	3.77e-06	2	68	2	2997024
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	3.77e-06	2	68	2	35898513
Pubmed	Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.	C4A C4B	3.77e-06	2	68	2	33353966
Pubmed	Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).	C4A C4B	3.77e-06	2	68	2	3008092
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	3.77e-06	2	68	2	8660986
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	3.77e-06	2	68	2	3624865
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	3.77e-06	2	68	2	28873507
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	3.77e-06	2	68	2	8428773
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	3.77e-06	2	68	2	21857912
Pubmed	The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4.	C4A C4B	3.77e-06	2	68	2	6609966
Pubmed	Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes.	C4A C4B	3.77e-06	2	68	2	2900855
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	3.77e-06	2	68	2	24638111
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	3.77e-06	2	68	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	3.77e-06	2	68	2	4514997
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	3.77e-06	2	68	2	276882
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	3.77e-06	2	68	2	21345967
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	3.77e-06	2	68	2	5919331
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	3.77e-06	2	68	2	6832377
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	3.77e-06	2	68	2	3167981
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	3.77e-06	2	68	2	3794341
Pubmed	Complement and c4 null alleles in severe chronic adult periodontitis.	C4A C4B	3.77e-06	2	68	2	17257223
Pubmed	Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events.	C4A C4B	3.77e-06	2	68	2	2272665
Pubmed	Multiple C4/Slp genes distinguished by expression after transfection.	C4A C4B	3.77e-06	2	68	2	3023818
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	3.77e-06	2	68	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	3.77e-06	2	68	2	30041577
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	3.77e-06	2	68	2	2572548
Pubmed	Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.	C4A C4B	3.77e-06	2	68	2	22785613
Pubmed	The complement component C4 of mammals.	C4A C4B	3.77e-06	2	68	2	2302180
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	3.77e-06	2	68	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	3.77e-06	2	68	2	34358307
Pubmed	Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.	C4A C4B	3.77e-06	2	68	2	32691186
Pubmed	Genetic deficiency in complement component 4b does not alter radiation-induced lung disease in mice.	C4A C4B	3.77e-06	2	68	2	23259761
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	3.77e-06	2	68	2	18360261
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	3.77e-06	2	68	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	3.77e-06	2	68	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	3.77e-06	2	68	2	29080553
Pubmed	Lack of evidence of a specific role for C4A gene deficiency in determining disease susceptibility among C4-deficient patients with systemic lupus erythematosus (SLE).	C4A C4B	3.77e-06	2	68	2	11168010
Pubmed	The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.	C4A C4B	3.77e-06	2	68	2	8390682
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	3.77e-06	2	68	2	26814963
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	3.77e-06	2	68	2	6589636
Pubmed	Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).	C4A C4B	3.77e-06	2	68	2	3902619
Interaction	TTYH1 interactions	S1PR5 ABCA3 GPAA1 BCAP29 UGT8 ABCB6 POMT1 ABCA7 CERS4	2.42e-07	300	60	9	int:TTYH1
Interaction	HTR3A interactions	ABCA3 LMF2 GPAA1 PIGG POMT1 ABCA7	8.15e-07	108	60	6	int:HTR3A
Interaction	VNN2 interactions	S1PR5 LMF2 GPAA1 POMT1	1.36e-05	49	60	4	int:VNN2
Cytoband	Ensembl 112 genes in cytogenetic band chr2q35	TMEM198 ABCB6 ASIC4 CHPF CXCR2	1.47e-06	129	68	5	chr2q35
Cytoband	2q35	TMEM198 ASIC4 CHPF CXCR2	6.08e-06	79	68	4	2q35
Cytoband	16p13.3	CCNF ABCA3 VASN BAIAP3	4.86e-04	244	68	4	16p13.3
Cytoband	22q13.33	LMF2 PPP6R2	1.47e-03	38	68	2	22q13.33
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	ABCB6 C4A C4B	1.63e-04	37	52	3	454
GeneFamily	Dolichyl D-mannosyl phosphate dependent mannosyltransferases\|Phosphatidylinositol glycan anchor biosynthesis	POMT1 PIGZ	2.88e-04	9	52	2	430
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	2.88e-04	9	52	2	1234
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN3A SCN4A	2.88e-04	9	52	2	1203
GeneFamily	ATP binding cassette subfamily A	ABCA3 ABCA7	7.22e-04	14	52	2	805
GeneFamily	Solute carriers	SLC41A2 SLC22A18 SLC7A4 SLC9A5 SLC16A8 SLC22A31	9.12e-04	395	52	6	752
GeneFamily	Endogenous ligands\|C1q and TNF related	ERFE C1QTNF1	1.21e-03	18	52	2	1372
GeneFamily	Glycosyl transferases group 1 domain containing\|Phosphatidylinositol glycan anchor biosynthesis	PIGG PIGZ	1.65e-03	21	52	2	680
GeneFamily	Beta 3-glycosyltransferases	B3GNT9 CHPF	2.15e-03	24	52	2	426
GeneFamily	Complement system\|Sushi domain containing	C4A C4B	4.80e-03	36	52	2	492
GeneFamily	CD molecules\|I-set domain containing\|Immunoglobulin like domain containing\|Interleukin receptors\|TIR domain containing	IL10RA CXCR2	6.49e-03	42	52	2	602
ToppCell	Control-Epithelial-Mesothelial\|World / Disease state, Lineage and Cell class	SLC7A4 TFPI2 C1QTNF1 C4A C4B ASIC4 STEAP2	6.58e-09	166	68	7	32ebaefa6c074b28193fff764ee7c2c0e9357e20
ToppCell	Control-Epithelial-Mesothelial\|Control / Disease state, Lineage and Cell class	SLC7A4 TFPI2 C1QTNF1 C4A C4B STEAP2	2.09e-07	166	68	6	1ed3788257e14f097862b999f020bfe2a57de52b
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-Mesothelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLC7A4 TFPI2 C1QTNF1 C4A C4B STEAP2	3.04e-07	177	68	6	0912a291cff32a4ff8a2d7680ed1a1cd867fb90f
ToppCell	IPF-Epithelial-Mesothelial\|IPF / Disease state, Lineage and Cell class	SH3TC2 TFPI2 C1QTNF1 C4A C4B STEAP2	3.36e-07	180	68	6	1fa54bf4dba72866b2295639d991af639341bc08
ToppCell	IPF-Epithelial-Mesothelial\|World / Disease state, Lineage and Cell class	SH3TC2 TFPI2 C1QTNF1 C4A C4B STEAP2	3.70e-07	183	68	6	7df20e3172a1220ff427f30181f4f0c3b7fe2d42
ToppCell	COPD-Epithelial-Mesothelial\|World / Disease state, Lineage and Cell class	SLC7A4 TFPI2 C1QTNF1 C4A C4B STEAP2	3.95e-07	185	68	6	23579988036fc1925992c31919750f9b3fe9f790
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SH3TC2 SLC7A4 TFPI2 C1QTNF1 TMEM235 CACNA2D3	3.95e-07	185	68	6	492529121cb9e88bd3c0db6b54af3cd2979572bc
ToppCell	facs-Lung-18m-Mesenchymal\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GNT9 SCN3A C4B FGFR4 CHPF FAM20A	4.47e-07	189	68	6	bdf8db938aa0863c4fed6fa99dcffd63c8c20c31
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GNT9 SCN3A C4B FGFR4 CHPF FAM20A	4.47e-07	189	68	6	40cbd679dc0548bf5207e1b033c0597886ad6fe1
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT9 ADRB3 C4B FGFR4 CHPF FAM20A	4.91e-07	192	68	6	5876ff75e273a48e7ad8236423fb41e4ae4c0a91
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT9 ADRB3 SCN3A FGFR4 CHPF FAM20A	5.06e-07	193	68	6	fa45042d30f9cfeed10e23270a78f18551219cfa
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT9 ADRB3 SCN3A FGFR4 CHPF FAM20A	5.06e-07	193	68	6	ab511ea9e09216a965b3ae5a94f8c3c1ae33d944
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM2\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC41A2 ADRB3 NFKB2 FGFR4 FAM20A	3.74e-06	153	68	5	5fbb90b8477f9fdabf3be19efd3068fbf70abee6
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM2-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SLC41A2 ADRB3 NFKB2 FGFR4 FAM20A	3.74e-06	153	68	5	2c46183481e6d5a7fa190a743062509465f88e56
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM2\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SLC41A2 ADRB3 NFKB2 FGFR4 FAM20A	3.74e-06	153	68	5	decc4f3098a9374a6b65c015a9d36380986290bf
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM2-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC41A2 ADRB3 NFKB2 FGFR4 FAM20A	3.74e-06	153	68	5	36a28805c0545c2f410c74a6ca0a70d840e75715
ToppCell	droplet-Marrow-BM-30m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	S1PR5 SH3TC2 MYADM UBR4 C4B	4.94e-06	162	68	5	75df7ff779a3b9159ba97d852da1f8df650b9ce5
ToppCell	Mild_COVID-19-Myeloid-MoAM2\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	SLC41A2 ADRB3 NFKB2 FGFR4 FAM20A	4.94e-06	162	68	5	e5fc80ab19d513af6a7e677a5e67bfebca2e963b
ToppCell	11.5-Distal-Mesenchymal-Mesenchyme_SERPINF1-high\|Distal / Age, Tissue, Lineage and Cell class	SLC7A4 TFPI2 CHPF FAM20A CHRM1	6.80e-06	173	68	5	6989c9cebcd81eccceac7e5a86152676ee959386
ToppCell	wk_08-11-Mesenchymal-Mesothelial-Late_mesothelial\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ABCA3 TFPI2 C1QTNF1 C4A ABCA7	8.69e-06	182	68	5	f8257c884393f168f605d371e0840cfca8d3657e
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCA3 EBPL CHPF CACNA2D3 SLC22A31	8.69e-06	182	68	5	d1a1feef318062f25493355d7beee8e5fb0e4206
ToppCell	LPS_only-Epithelial_alveolar\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC41A2 ABCA3 EBPL CACNA2D3 SLC22A31	9.66e-06	186	68	5	e0a2ea4b46af742bc7c9b2072bb85e27d5c92712
ToppCell	LPS-antiTNF-Epithelial_alveolar\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC41A2 ABCA3 EBPL CACNA2D3 SLC22A31	9.91e-06	187	68	5	201ff693e4756ee3e44762885b3a303a77eb535b
ToppCell	LPS-IL1RA-Epithelial_alveolar\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC41A2 ABCA3 EBPL CACNA2D3 SLC22A31	1.02e-05	188	68	5	6164d467b612767ceba15de34176bcc8e8c36ab8
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SH3TC2 SLC7A4 TFPI2 TMEM235 CACNA2D3	1.02e-05	188	68	5	9655a4c47b644a870017d349b99063e17dbae572
ToppCell	COPD-Epithelial-Mesothelial\|Epithelial / Disease state, Lineage and Cell class	TFPI2 C1QTNF1 C4A C4B STEAP2	1.02e-05	188	68	5	159d63ecc3653a7449fc6acefd6ef0464845260e
ToppCell	COPD-Epithelial-Mesothelial\|COPD / Disease state, Lineage and Cell class	TFPI2 C1QTNF1 C4A C4B STEAP2	1.04e-05	189	68	5	79bb2593ad5d17f94b17972884241f03a0f43770
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT9 ADRB3 VASN SCN3A FGFR4	1.04e-05	189	68	5	32e6d6285b258831b965281224ff2aaeecdcb5f5
ToppCell	Adult\|World / Lineage, Cell type, age group and donor	SLC41A2 ABCA3 FAM20A CACNA2D3 SLC22A31	1.04e-05	189	68	5	5cd285bfad973125d46d704fec18b21266a63379
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT9 ADRB3 VASN SCN3A FGFR4	1.04e-05	189	68	5	385ef7bbd76c8047aeecf6542377d4213b5da5db
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GNT9 ADRB3 SCN3A C4B FGFR4	1.04e-05	189	68	5	e76dc36a01d8ad7590b3acc4c46abfcb76857448
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GNT9 SCN3A C4B CHPF FAM20A	1.10e-05	191	68	5	094c9d3270fc1e487ccf10fb4936af5f081f6009
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GNT9 ADRB3 SCN3A C4B FGFR4	1.10e-05	191	68	5	8a73d2df079566fca4cbb5cdb85721c2e87134c8
ToppCell	facs-Lung-24m-Mesenchymal\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GNT9 SCN3A C4B CHPF FAM20A	1.10e-05	191	68	5	ba02cbdfda6a94374a6472eb88499059979af472
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast-alveolar_fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GNT9 ADRB3 SCN3A FGFR4 FAM20A	1.10e-05	191	68	5	d4f535b06ad483448ab692e9900c872c78cbed60
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GNT9 ADRB3 VASN SCN3A FGFR4	1.10e-05	191	68	5	d04e6292fef189b8d8ed0f4b0c310b2b250fd30e
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GNT9 ADRB3 VASN SCN3A FGFR4	1.10e-05	191	68	5	de3e9b704621b26836c2ddc39fa3e840dfb4541b
ToppCell	droplet-Lung-21m-Mesenchymal\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GNT9 ADRB3 SCN3A C4B FGFR4	1.10e-05	191	68	5	10a9db1caa0fdb51ace8537f42b2c66f7c97e0f5
ToppCell	Mild-Myeloid-mDC\|Mild / Condition, Lineage, Cell class and cell subclass	SLC41A2 GPR31 NFKB2 PTGIR CACNA2D3	1.13e-05	192	68	5	da3952bd5c96242c15eb76678d0608ae2926a16e
ToppCell	Mild-Myeloid-mDC-\|Mild / Condition, Lineage, Cell class and cell subclass	SLC41A2 GPR31 NFKB2 PTGIR CACNA2D3	1.13e-05	192	68	5	8520b3fdf4508ac66f7918da613abc928ab5832a
ToppCell	3'_v3-Lung-Myeloid_Dendritic\|Lung / Manually curated celltypes from each tissue	SLC41A2 ADRB3 TFPI2 KCNK6 PTGIR	1.21e-05	195	68	5	b748cb15846345363e8c2ee5936bb42bba3ba9a7
ToppCell	BAL-Mild-Myeloid-cDC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SLC41A2 GPR31 NFKB2 PTGIR CACNA2D3	1.21e-05	195	68	5	6ba23e19801305e071b0e4aaf1ee6f53f3b027d3
ToppCell	BAL-Mild-Myeloid-cDC-cDC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC41A2 GPR31 NFKB2 PTGIR CACNA2D3	1.21e-05	195	68	5	66e5fd9f3208a06d617c5e994822bf57dceae7e2
ToppCell	BAL-Mild-Myeloid-cDC-cDC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SLC41A2 GPR31 NFKB2 PTGIR CACNA2D3	1.21e-05	195	68	5	7209babdff96c93cd52cfe5d5cfd7e3c0274d8dd
ToppCell	BAL-Mild-Myeloid-cDC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC41A2 GPR31 NFKB2 PTGIR CACNA2D3	1.21e-05	195	68	5	9e5cf33b5dd455efa464a63d7116786c0786aefd
ToppCell	Mild_COVID-19-Myeloid-cDC\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	SLC41A2 GPR31 NFKB2 PTGIR CACNA2D3	1.21e-05	195	68	5	24149bb6933135b1a0a5c7f505914942b3782c3a
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SLC41A2 ABCA3 EBPL CHPF SLC22A31	1.27e-05	197	68	5	1638959d7aecb9fc5285eb7e4a3103ca437989e2
ToppCell	LPS_only-Epithelial_alveolar-AT_2\|LPS_only / Treatment groups by lineage, cell group, cell type	SLC41A2 ABCA3 EBPL CHPF SLC22A31	1.31e-05	198	68	5	d087e738d69ca9853553fde46d4e7a8906439d32
ToppCell	Biopsy_Other_PF-Mesenchymal-Mesothelial_cells\|Biopsy_Other_PF / Sample group, Lineage and Cell type	SLC7A4 TFPI2 C4A C4B STEAP2	1.31e-05	198	68	5	86736f01e61bf4961f060b24ee1f1f48340737dd
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SLC41A2 ABCA3 EBPL CHPF SLC22A31	1.31e-05	198	68	5	aa80315395cb5dffc25927c8a77cd2037aea8772
ToppCell	LPS_only-Epithelial_alveolar\|LPS_only / Treatment groups by lineage, cell group, cell type	SLC41A2 ABCA3 EBPL CHPF SLC22A31	1.31e-05	198	68	5	655df75b9692d815c7f6910275e1f684ac63bf62
ToppCell	distal-1-mesenchymal-Alveolar_Fibroblast\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	VASN FGFR4 PKD1L2 STEAP2 PTGIR	1.31e-05	198	68	5	6594c35ab203dc51462167c61807b0d49fa30fb2
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P1-P1_1\|Striatum / BrainAtlas - Mouse McCarroll V32	S1PR5 SH3TC2 UGT8 CXCR2	3.01e-05	116	68	4	c19974992b315fb873664fe3f5077ff8e907e30c
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P1\|Striatum / BrainAtlas - Mouse McCarroll V32	S1PR5 SH3TC2 B3GNT9 UGT8	6.99e-05	144	68	4	9d6133558728fa148050eb4f0be33756d71310b0
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_dendritic-myeloid_dendritic_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ADRB3 GPR31 KCNK6 PIGZ	7.98e-05	149	68	4	71d72a6e7b128ee96161e08f6a0d77be925e73a1
ToppCell	368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ERFE CHST6 PIGZ DNAH14	8.62e-05	152	68	4	ca23261d8ef263cc697b8d7e7cb2afec8bc564f2
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GPAA1 TFPI2 SCN3A UBR4	9.53e-05	156	68	4	895927228c93cd090303984c5be6ebfb59ed6f3a
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-3\|TCGA-Colorectal / Sample_Type by Project: Shred V9	S1PR5 GPAA1 VASN PTGIR	9.53e-05	156	68	4	b464871ad7c8ce0d58013a27996639eac1e526d8
ToppCell	368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ERFE CHST6 PIGZ DNAH14	1.05e-04	160	68	4	19105debef96ea0c267d6a1d332303ec668ae47e
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Adult / Lineage, Cell type, age group and donor	ABCA3 OR56B1 FAM20A SLC22A31	1.13e-04	163	68	4	e819a1d6d28290854aa0672b3a18fa9e293d8f23
ToppCell	droplet-Thymus-nan-21m-Myeloid-Plasma_cells_and_B_cells\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYADM B3GNT9 CHPF CACNA2D3	1.18e-04	165	68	4	21a82a975f550080b6674750b06212205cd16742
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMEM44 KCNK6 ASIC4 CHRM1	1.24e-04	167	68	4	a813b95c2fafb638b249bc4fa4f708c6f39ad444
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL10RA S1PR5 FAM20A PTGIR	1.27e-04	168	68	4	e979a4fbeb9f21048b47d69e6da75c57650697f2
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l15\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMEM198 ASIC4 CHPF PTGIR	1.27e-04	168	68	4	a8958b94ffc3423d56c250796dd253884b46f9d9
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-AT2_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCA3 EBPL CACNA2D3 SLC22A31	1.45e-04	174	68	4	d0e3d15731de6c19c232e3aa492c39d8151cf4ed
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CEACAM19 UGT8 STEAP2 PIGZ	1.48e-04	175	68	4	6759d200a133034756de9cdf2d5daceca927aac9
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC41A2 ABCA3 CACNA2D3 SLC22A31	1.62e-04	179	68	4	fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC41A2 ABCA3 CACNA2D3 SLC22A31	1.62e-04	179	68	4	7db6b97a1c4c7a163d5da4351ba36ac1785d9d7b
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_10\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC41A2 GPR31 NFKB2 PTGIR	1.65e-04	180	68	4	32d871738a24071b70084a7e80148a516110c78b
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC41A2 ABCA3 CACNA2D3 SLC22A31	1.65e-04	180	68	4	b798a3fa2dd15b68aa4267f665559527043dcc07
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C4B CHPF PTGIR CACNA2D3	1.65e-04	180	68	4	e9785ac2806103f725f5a5208495826354ec6e22
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_10\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SLC41A2 GPR31 NFKB2 PTGIR	1.65e-04	180	68	4	067ca8a15228c7f3b3bc7aecbc9b1611ca05e176
ToppCell	facs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC41A2 ANKRD23 FGFR4 STEAP2	1.65e-04	180	68	4	d33bb00f2b7d07dda9015cb8eafd742c2b2e9ace
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC41A2 ABCA3 CACNA2D3 SLC22A31	1.69e-04	181	68	4	0513b9e6673ff7bf8e72ba123ca3794b65d10170
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-secretory_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERFE B3GNT9 C1QTNF1 CHPF	1.69e-04	181	68	4	b203b616584cdbd0bbb0e382b2916d0bd49d3526
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERFE B3GNT9 C1QTNF1 CHPF	1.69e-04	181	68	4	c748c16fd20d1949d33ff6290dc9d9016c4dc86c
ToppCell	VE-matDC\|VE / Condition, Cell_class and T cell subcluster	SLC41A2 TFPI2 FAM20A PTGIR	1.69e-04	181	68	4	982fd96ef75bc9ab2c2f4970c01b76ba7a164871
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ABCA3 FAM20A DNAH14 SLC22A31	1.69e-04	181	68	4	576da14ab3107f89e1f44a4a439d1bef5bb42370
ToppCell	VE-matDC-\|VE / Condition, Cell_class and T cell subcluster	SLC41A2 TFPI2 FAM20A PTGIR	1.69e-04	181	68	4	6252184ef098b911df50be4fe1b5565849a5b6b8
ToppCell	Healthy_Control-Lymphoid-T-\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	CCNF ERFE PSMC3IP ASIC4	1.69e-04	181	68	4	ac1ee313910c05b1b3cb497bae14565464919c21
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	S1PR5 SH3TC2 UGT8 TMEM235	1.72e-04	182	68	4	d524ad5cf00f05ee27c9db2ffa2d4e30a1e2e21a
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-AT1-AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCA3 EBPL CACNA2D3 SLC22A31	1.72e-04	182	68	4	cc79e0cc21e2fdc4ef77f052818d27b9f707aec1
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC41A2 ABCA3 CHPF SLC22A31	1.72e-04	182	68	4	1e2149b222a3e9f64841aed45288a6f29394e7b0
ToppCell	metastatic_Lymph_Node-Myeloid_cells-CD1c+_DCs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	MYADM KCNK6 PTGIR CACNA2D3	1.72e-04	182	68	4	551d301adfb4d5046c5f60f6996450621b04e9b2
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC41A2 ABCA3 CACNA2D3 SLC22A31	1.72e-04	182	68	4	17ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC41A2 ABCA3 CHPF SLC22A31	1.76e-04	183	68	4	5f2db95d44b7de68779de098892892af540fd431
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	S1PR5 SH3TC2 UGT8 TMEM235	1.76e-04	183	68	4	5472cdce6d99314d229418412acf1fff6340db7d
ToppCell	facs-Liver-Hepatocytes-24m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC22A18 ABCB6 C4B FGFR4	1.76e-04	183	68	4	d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-AT1-AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCA3 EBPL CACNA2D3 SLC22A31	1.76e-04	183	68	4	06ac66726ec53db810ebb90ec69cfdb903da53f6
ToppCell	cellseq-Immune-Immune_Myeloid-Myeloid_Dendritic-maDC\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IL10RA SLC41A2 ADRB3 PTGIR	1.76e-04	183	68	4	e01dacb08a9c36cf09c0b6764ce032a7232d4cdc
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCA3 EBPL CACNA2D3 SLC22A31	1.76e-04	183	68	4	ff6dde877659cde9daa3263db0932c9c9ef1adac
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	S1PR5 SH3TC2 UGT8 TMEM235	1.76e-04	183	68	4	93213124e55d1b673dd345188caf8b5bd31d99fe
ToppCell	LPS_only-Epithelial_alveolar-AT_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC41A2 ABCA3 CACNA2D3 SLC22A31	1.76e-04	183	68	4	e972432dd4d1bd31bb0982f4df3061e5e152658f
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	S1PR5 SH3TC2 UGT8 TMEM235	1.80e-04	184	68	4	f6d6b3ddada66dae28d3306415bf4efe0934208a
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-AT2_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCA3 EBPL CACNA2D3 SLC22A31	1.80e-04	184	68	4	7cc5796557379c3d1db078c1aeda40659c6e401c
ToppCell	wk_20-22-Mesenchymal-Mesothelial\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	SLC7A4 TFPI2 C1QTNF1 C4A	1.80e-04	184	68	4	804f8a41cd6b1361448872bf352bf0a38a0fac66
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	S1PR5 SH3TC2 UGT8 TMEM235	1.80e-04	184	68	4	5939527d24d299e562e707469c9123890edd76be
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCA3 EBPL CACNA2D3 SLC22A31	1.80e-04	184	68	4	cdf6f1c6cce97a7effa0c55959652e2c0b6992b3
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GNT9 SLC9A5 TFPI2 FAM20A	1.80e-04	184	68	4	e33e2a887aafba7b6a31f00bb0dbe974b4359fd6
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC41A2 ABCA3 CACNA2D3 SLC22A31	1.80e-04	184	68	4	d0c212a8fbaad24597a84018442b25c61c17ea58
Drug	salbutamol	ADRB3 DCD NFKB2 SCN3A SCN4A ASIC4 CHRM1	2.19e-07	146	66	7	CID000002083
Drug	Pirmenolum	SCN3A SCN4A ASIC4 CHRM1	9.17e-07	26	66	4	CID000004853
Drug	nefopam	SLC22A18 SCN3A SCN4A ASIC4	1.07e-06	27	66	4	CID000004450
Drug	verapamil	ABCA3 SCN3A SCN4A ABCB6 KCNK6 ASIC4 CHRM1 PTGIR ABCA7 CACNA2D3	1.39e-06	490	66	10	CID000002520
Drug	NSC93767	SCN3A SCN4A ASIC4 CHRM1	2.18e-06	32	66	4	CID000005658
Drug	5-hydroxypropafenone	ADRB3 SCN3A SCN4A ASIC4	2.80e-06	34	66	4	CID000107927
Drug	S-ropivacaine	SLC22A18 SCN3A SCN4A ASIC4	5.44e-06	40	66	4	CID000071273
Drug	pilsicainide	SCN3A SCN4A ASIC4 CHRM1	9.59e-06	46	66	4	CID000004820
Drug	isradipine	SCN3A SCN4A ASIC4 PTGIR CACNA2D3	1.07e-05	100	66	5	CID000003784
Drug	diprafenone	SCN3A SCN4A ASIC4	2.18e-05	19	66	3	CID000071249
Drug	triamterene	SLC9A5 SCN3A SCN4A ASIC4	2.43e-05	58	66	4	CID000005546
Drug	N-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide	SCN3A SCN4A	2.48e-05	3	66	2	ctd:C561228
Drug	2-aminothiophenol	C4A C4B	2.48e-05	3	66	2	ctd:C005464
Drug	bepridil	SCN3A SCN4A ASIC4 CHRM1 CACNA2D3	3.27e-05	126	66	5	CID000002351
Drug	pseudococaine	CCNF ADRB3 NFKB2 SCN3A SCN4A ANKRD23 ASIC4 CHRM1 CXCR2	3.77e-05	570	66	9	CID000002826
Drug	saxitoxin	SCN3A SCN4A ASIC4 PTGIR	3.82e-05	65	66	4	CID000037165
Drug	AC1L1CQC	SCN3A SCN4A ASIC4 CHRM1	3.82e-05	65	66	4	CID000002012
Drug	resiniferatoxin	SCN3A SCN4A KCNK6 ASIC4	4.05e-05	66	66	4	CID000104826
Drug	disopyramide	SCN3A SCN4A ASIC4 CHRM1	4.05e-05	66	66	4	CID000003114
Drug	quindine	SLC22A18 SCN3A SCN4A KCNK6 ASIC4 CHRM1	4.15e-05	219	66	6	CID000001065
Drug	UH-AH 37	DCD CHRM1	4.95e-05	4	66	2	CID000129139
Drug	AC1NT1AF	SCN3A SCN4A ASIC4	5.11e-05	25	66	3	CID005322157
Drug	1, 3-diallylurea	SCN3A SCN4A ASIC4 CHRM1	6.36e-05	74	66	4	CID000074537
Drug	PbTx-1	SCN3A SCN4A ASIC4	6.47e-05	27	66	3	CID006437089
Drug	AC1L1MOZ	SCN3A SCN4A ASIC4	6.47e-05	27	66	3	CID000031958
Drug	diphenhydramine	SCN3A SCN4A ASIC4 CHRM1	6.71e-05	75	66	4	CID000003100
Drug	paraben	SCN3A SCN4A ASIC4	7.24e-05	28	66	3	CID000007175
Drug	procaine	SCN3A SCN4A ASIC4 CHRM1 CACNA2D3	8.24e-05	153	66	5	CID000004914
Drug	tocainide	SCN3A SCN4A ASIC4	8.93e-05	30	66	3	CID000038945
Drug	bupropion	ADRB3 SCN3A SCN4A ASIC4	9.06e-05	81	66	4	CID000000444
Drug	lidocaine	PHKA2 SCN3A SCN4A KCNK6 ASIC4	1.02e-04	160	66	5	CID000003676
Drug	APETx1, Anthopleura elegantissima	SCN3A SCN4A	1.23e-04	6	66	2	ctd:C475726
Drug	HUK 978	ADRB3 CHRM1	1.23e-04	6	66	2	CID000065826
Drug	potassium	SLC7A4 SLC9A5 NFKB2 SCN3A SCN4A KCNK6 ASIC4 CHRM1 PTGIR CERS4 CACNA2D3	1.39e-04	1008	66	11	CID000000813
Drug	riluzole	SCN3A SCN4A KCNK6 ASIC4 CACNA2D3	1.51e-04	174	66	5	CID000005070
Drug	isoflurane	SLC22A18 VASN SCN3A SCN4A ASIC4 CHRM1	1.57e-04	279	66	6	CID000003763
Drug	benzocaine	SCN3A SCN4A ASIC4	1.68e-04	37	66	3	CID000002337
Drug	aprindine	SCN3A SCN4A ASIC4	1.83e-04	38	66	3	CID000002218
Drug	NSC7524	SCN3A SCN4A ASIC4 CHRM1 CACNA2D3	1.86e-04	182	66	5	CID000005657
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN3A SCN4A	2.19e-04	10	66	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN3A SCN4A	2.19e-04	10	66	2	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN3A SCN4A	3.21e-04	12	66	2	DOID:0060170 (implicated_via_orthology)
Disease	Rhabdomyosarcoma	SLC22A18 FGFR4	5.08e-04	15	66	2	C0035412
Disease	focal segmental glomerulosclerosis	KCNK6 FGFR4	5.79e-04	16	66	2	EFO_0004236
Disease	exploratory eye movement measurement	SH3TC2 UGT8 CACNA2D3	8.05e-04	81	66	3	EFO_0007700
Disease	serum metabolite measurement	SH3TC2 GPAA1 DCD TMEM235 PKD1L2 FAM20A ABCA7 CERS4	1.19e-03	945	66	8	EFO_0005653
Disease	level of Sphingomyelin (d38:1) in blood serum	PELP1 CERS4	2.06e-03	30	66	2	OBA_2045180

Protein segments in the cluster

Peptide	Gene	Start	Entry
DGLSSALLILYLDSA	ESYT2	531	A0FGR8
IGSLVLLLHDSSDYL	CERS4	231	Q9HA82
LLLLYGAELGVRNAA	ANKRD23	261	Q86SG2
LALVALGALDTALYA	C4B	596	P0C0L5
LEVASGLFELYLTLA	BAIAP3	656	O94812
VYLLNLALADLLLAA	GPR31	51	O00270
ILYASGSLALAVLLL	FGFR4	371	P22455
AASGCAYLILLFLIE	ABCA3	1311	Q99758
YLLLASVLESLAGAC	ABCB6	106	Q9NP58
AAVATFLYAEIGLIL	BCAP29	6	Q9UHQ4
AIAISLAIAAGAYIL	SLC7A4	271	O43246
EAALAGALLALAVLA	ADRB3	36	P13945
AQVSGLLLLDAALYG	ABCA7	731	Q8IZY2
YLFSLALLANGLTDL	SLC16A8	321	O95907
LLAGALAAYAAYLVL	KCNK6	6	Q9Y257
LLFLAAVAGALVYAE	LACRT	6	Q9GZZ8
VLILASYGAIAAALR	OR10AC1	216	Q8NH08
AEAAAGAAGILLRYL	PSMC3IP	6	Q9P2W1
AEAVVLTLLAIYAAG	GPAA1	461	O43292
YLLNLALADLLFALT	CXCR2	86	P25025
RLLLVYAGLLAAAAA	ERFE	11	Q4G0M1
LSLPLALLYLSALAA	OR56B1	36	Q8NGI3
LLFLTALAGALVCAY	DCD	6	P81605
VALDGSLALFLIYAI	EBPL	106	Q9BY08
SGLALLSVLLYATAL	MYADM	241	Q96S97
AFVLLLSGALAYCLA	IL10RA	241	Q13651
EGVLADLALYTAACL	MROH6	106	A6NGR9
ALALLTSLAAFLYQA	ASIC4	71	Q96FT7
SLLASLHTLLGALYE	PELP1	266	Q8IZL8
AAADAALGYIIAFLV	PKD1L2	2266	Q7Z442
PFLLILASYGAIAAA	OR1K1	211	Q8NGR3
VSGSLALAIYALLSL	POMT1	601	Q9Y6A1
AYCLLLAFASGLVLS	C1QTNF1	11	Q9BXJ1
AYAPARLAAAALLLA	CCNF	446	P41002
ALLAAALLYAALGDV	CACNA2D3	16	Q8IZS8
DIAFVLLLGAALLYF	UGT8	476	Q16880
NYFLLSLACADLIIG	CHRM1	61	P11229
SLAAGALLISCIAYL	CEACAM19	166	Q7Z692
ATRGALLYFLVADLT	DNAH14	2711	Q0VDD8
GLEAAALVFLLLTAD	SLC22A31	376	A6NKX4
SDLLAGAAYAANILL	S1PR5	81	Q9H228
LALVALGALDTALYA	C4A	596	P0C0L4
LGGDESLLSLLYDFL	PPP6R2	96	O75170
LYILSSLLAEGFLAA	PHKA2	406	P46019
GDSLAAEYLILHLIS	MCMBP	361	Q9BTE3
LLLGLGSFLEDARAY	CARS2	366	Q9HA77
ILLSSGALAFEDIYI	SCN4A	1041	P35499
LLATLSLLLELAVYG	LMF2	311	Q9BU23
TLLLLGALLSADLYF	FAM20A	11	Q96MK3
LLDFLLFGSLISAVD	SLC9A5	171	Q14940
TEYFLLALAAAVLLG	SH3TC2	1231	Q8TF17
YLTALGDLLGTALLA	SLC41A2	541	Q96JW4
LLSLVYLAGLLAAAY	STEAP2	266	Q8NFT2
ILLSSGALAFEDIYI	SCN3A	1216	Q9NY46
ALTLSFLAALALYLL	SLC22A18	91	Q96BI1
FLAALALYLLLAAAS	SLC22A18	96	Q96BI1
LLGASLGLLLYAQRD	B3GNT9	16	Q6UX72
PGDAAAALTLLLLYE	CHPF	536	Q8IZ52
LAEIRALYAFTGLSL	CHST6	281	Q9GZX3
LLSFALLAAAVASDY	TMEM235	16	A6NFC5
LAYAGLVALLVAAIF	PTGIR	186	P43119
LLSALAGLLYASAIV	TMEM44	266	Q2T9K0
LLLTALSFALDGAVY	PIGZ	131	Q86VD9
ALAAVLLAALAAVGA	VASN	581	Q6EMK4
ILLLFLTEAALGDAA	TFPI2	11	P48307
EIYSGLVLLAALLFR	PIGG	796	Q5H8A4
LYAALTALLAAGSQL	UBR4	966	Q5T4S7
AALIATAADYFAELL	TMEM198	181	Q66K66
LLDYGVTADARALLA	NFKB2	461	Q00653