Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ciliary neurotrophic factor receptor activity	IL6ST CNTFR	5.31e-05	4	60	2	GO:0004897
GeneOntologyBiologicalProcess	central nervous system neuron development	MYCBP2 NTRK2 ARX GATA2 SPG11 NIN	4.26e-07	99	60	6	GO:0021954
GeneOntologyBiologicalProcess	central nervous system development	MYCBP2 NTRK2 CNTN5 SYNE2 SCN5A ARX CNTNAP2 GATA2 SPG11 SOX8 IL6ST PROP1 NIN	3.18e-05	1197	60	13	GO:0007417
GeneOntologyBiologicalProcess	axonogenesis	MAP2 MYCBP2 NTRK2 CNTN5 ARX CNTNAP2 SPG11 DNM2 NIN	3.52e-05	566	60	9	GO:0007409
GeneOntologyBiologicalProcess	central nervous system neuron differentiation	MYCBP2 NTRK2 ARX GATA2 SPG11 NIN	3.94e-05	217	60	6	GO:0021953
GeneOntologyBiologicalProcess	ciliary neurotrophic factor-mediated signaling pathway	IL6ST CNTFR	8.27e-05	5	60	2	GO:0070120
GeneOntologyBiologicalProcess	axon development	MAP2 MYCBP2 NTRK2 CNTN5 ARX CNTNAP2 SPG11 DNM2 NIN	9.28e-05	642	60	9	GO:0061564
GeneOntologyBiologicalProcess	neuron projection morphogenesis	MAP2 MYCBP2 NTRK2 CNTN5 ARX CNTNAP2 SPG11 RIMS1 DNM2 NIN	9.66e-05	802	60	10	GO:0048812
GeneOntologyBiologicalProcess	central nervous system projection neuron axonogenesis	MYCBP2 SPG11 NIN	1.09e-04	32	60	3	GO:0021952
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	MAP2 MYCBP2 NTRK2 CNTN5 ARX CNTNAP2 SPG11 RIMS1 DNM2 NIN	1.15e-04	819	60	10	GO:0120039
GeneOntologyBiologicalProcess	cell projection morphogenesis	MAP2 MYCBP2 NTRK2 CNTN5 ARX CNTNAP2 SPG11 RIMS1 DNM2 NIN	1.23e-04	826	60	10	GO:0048858
GeneOntologyBiologicalProcess	brainstem development	SCN5A CNTFR	2.30e-04	8	60	2	GO:0003360
GeneOntologyBiologicalProcess	central nervous system neuron axonogenesis	MYCBP2 SPG11 NIN	2.66e-04	43	60	3	GO:0021955
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	MAP2 MYCBP2 NTRK2 CNTN5 ARX CNTNAP2 SPG11 DNM2 NIN	2.91e-04	748	60	9	GO:0048667
GeneOntologyCellularComponent	ciliary neurotrophic factor receptor complex	IL6ST CNTFR	2.68e-05	3	63	2	GO:0070110
MousePheno	perinatal lethality	MIA3 MYCBP2 NTRK2 UBR4 ARX GATA2 DCHS1 IL6ST LUZP1 CNTFR DNM2 PROP1 MOCOS CHUK	2.15e-05	1130	49	14	MP:0002081
MousePheno	perinatal lethality, complete penetrance	MIA3 MYCBP2 NTRK2 UBR4 ARX DCHS1 IL6ST LUZP1 CNTFR DNM2 CHUK	2.73e-05	712	49	11	MP:0011089
MousePheno	small facial motor nucleus	NTRK2 CNTFR	1.20e-04	5	49	2	MP:0000910
MousePheno	absent bone trabeculae	KL MIA3	1.20e-04	5	49	2	MP:0010870
MousePheno	wide sternum	DCHS1 CHUK	1.20e-04	5	49	2	MP:0012279
Domain	LRRC37AB_C	LRRC37A LRRC37A2	6.48e-05	4	62	2	PF14914
Domain	LRRC37_N	LRRC37A LRRC37A2	6.48e-05	4	62	2	IPR032754
Domain	LRRC37AB_C	LRRC37A LRRC37A2	6.48e-05	4	62	2	IPR029423
Domain	LRRC37	LRRC37A LRRC37A2	6.48e-05	4	62	2	PF15779
Domain	LRRC37A/B-like	LRRC37A LRRC37A2	6.48e-05	4	62	2	IPR015753
Domain	DUF4599	SPATA31D4 SPATA31D3	7.00e-04	12	62	2	PF15371
Domain	DUF4599	SPATA31D4 SPATA31D3	7.00e-04	12	62	2	IPR027970
Pubmed	High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.	KL CLCN7 NTRK2 GATA2 PAX1 IL6ST CNTFR PROP1 CHUK	3.50e-08	383	64	9	19453261
Pubmed	Genome-wide approach to identify second gene targets for malignant rhabdoid tumors using high-density oligonucleotide microarrays.	CNTNAP2 SMARCB1	3.33e-06	2	64	2	24418192
Pubmed	Expression of tyrosine kinase receptor B in eutopic endometrium of women with adenomyosis.	NTRK2 MUC16	3.33e-06	2	64	2	21079983
Pubmed	Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3).	PEG3 ZIM2	3.33e-06	2	64	2	10708526
Pubmed	Expression of interleukin-6 family receptors in NK92 cells is regulated by cytokines and not through direct interaction with Plasmodium falciparum-infected erythrocytes.	IL6ST CNTFR	3.33e-06	2	64	2	23398366
Pubmed	Cytoplasmic interaction of the tumour suppressor protein hSNF5 with dynamin-2 controls endocytosis.	SMARCB1 DNM2	3.33e-06	2	64	2	23851497
Pubmed	Defining the membrane proteome of NK cells.	INTS5 MIA3 LMF2 CLCN7 MYCBP2 MED16 MAP4K1 UBR4 LARP4 IL6ST LUZP1	8.51e-06	1168	64	11	19946888
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MIA3 MYCBP2 NTRK2 SYNE2 UBR4 DCHS1 RIMS1 LUZP1 DNM2 SMG6	9.89e-06	963	64	10	28671696
Pubmed	An alternative mechanism of clathrin-coated pit closure revealed by ion conductance microscopy.	CLCN7 DNM2	9.99e-06	3	64	2	22564416
Pubmed	Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130.	IL6ST CNTFR	9.99e-06	3	64	2	19386761
Pubmed	Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells.	IL6ST CNTFR	9.99e-06	3	64	2	12629177
Pubmed	Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex.	IL6ST CNTFR	9.99e-06	3	64	2	12707266
Pubmed	Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth--structure and function of the second kinase noncatalytic C-lobe domain.	MAP2 FRMPD2	9.99e-06	3	64	2	21385318
Pubmed	Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons.	MAP2 CNTNAP2	9.99e-06	3	64	2	25918374
Pubmed	The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine.	IL6ST CNTFR	2.00e-05	4	64	2	11285233
Pubmed	Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.	LRRC37A LRRC37A2	2.00e-05	4	64	2	22419166
Pubmed	TrkB regulates neocortex formation through the Shc/PLCgamma-mediated control of neuronal migration.	MAP2 NTRK2	3.32e-05	5	64	2	15372074
Pubmed	Complementary tissue-specific expression of LIF and LIF-receptor mRNAs in early mouse embryogenesis.	IL6ST CNTFR	3.32e-05	5	64	2	8843390
Pubmed	The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates interleukin-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR).	IL6ST CNTFR	3.32e-05	5	64	2	24802752
Pubmed	SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.	RNF31 CHUK	3.32e-05	5	64	2	21455181
Pubmed	Expression of neurotrophin receptors by retinoinvasive uveal melanoma.	NTRK2 CNTFR	3.32e-05	5	64	2	22343487
Pubmed	Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes.	IL6ST CNTFR	3.32e-05	5	64	2	17436251
Pubmed	Centrosome-related genes, genetic variation, and risk of breast cancer.	CDC25B DNM2 CHUK NIN	3.87e-05	102	64	4	20508983
Pubmed	Cardiotrophin-1, a muscle-derived cytokine, is required for the survival of subpopulations of developing motoneurons.	IL6ST CNTFR	4.98e-05	6	64	2	11160399
Pubmed	Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex.	IL6ST CNTFR	4.98e-05	6	64	2	18775332
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	MIA3 LMF2 CLCN7 SYNE2 LARP4 JPH3	6.68e-05	375	64	6	32788342
Pubmed	Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer.	IL6ST CNTFR	6.96e-05	7	64	2	20584990
Pubmed	Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF.	IL6ST CNTFR	6.96e-05	7	64	2	12643274
Pubmed	A novel inhibitor of nuclear factor kappa-B kinase subunit gamma mutation identified in an incontinentia pigmenti patient with syndromic tooth agenesis.	RNF31 CHUK	6.96e-05	7	64	2	30913450
Pubmed	Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1.	UBR4 SPG11	9.27e-05	8	64	2	37871017
Pubmed	SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex.	RNF31 CHUK	9.27e-05	8	64	2	21455180
Pubmed	Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.	MAP2 NTRK2 PEG3 ARX	1.12e-04	134	64	4	19030180
Pubmed	The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains.	RNF31 CHUK	1.19e-04	9	64	2	34755089
Pubmed	Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain.	MAP2 NTRK2	1.19e-04	9	64	2	12798291
Pubmed	Branching and nucleokinesis defects in migrating interneurons derived from doublecortin knockout mice.	MAP2 ARX	1.19e-04	9	64	2	16571605
Pubmed	Lack of interaction between NEMO and SHARPIN impairs linear ubiquitination and NF-κB activation and leads to incontinentia pigmenti.	RNF31 CHUK	1.19e-04	9	64	2	28249776
Pubmed	EGF transactivation of Trk receptors regulates the migration of newborn cortical neurons.	MAP2 NTRK2	1.19e-04	9	64	2	23416450
Pubmed	Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor.	IL6ST CNTFR	1.19e-04	9	64	2	15051883
Pubmed	Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.	UBR4 DDB2	1.19e-04	9	64	2	17855541
Pubmed	A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation.	MAP2 NIN	1.49e-04	10	64	2	25220058
Pubmed	Targeted inactivation of a developmentally regulated neural plectin isoform (plectin 1c) in mice leads to reduced motor nerve conduction velocity.	MAP2 CNTNAP2	1.49e-04	10	64	2	19625254
Pubmed	Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology.	MAP2 CNTNAP2	1.49e-04	10	64	2	32675284
Pubmed	Functional and comparative genomic analysis of the piebald deletion region of mouse chromosome 14.	ACOD1 MYCBP2	1.49e-04	10	64	2	12160731
Pubmed	Evolutionary dynamism of the primate LRRC37 gene family.	LRRC37A LRRC37A2	1.49e-04	10	64	2	23064749
Pubmed	Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched.	DISP2 PAX1	1.49e-04	10	64	2	12372301
Pubmed	Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders.	NTRK2 CNTFR	1.49e-04	10	64	2	18203754
Pubmed	Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease.	NTRK2 CNTFR	1.49e-04	10	64	2	20219210
Pubmed	Mechanism underlying IκB kinase activation mediated by the linear ubiquitin chain assembly complex.	RNF31 CHUK	1.49e-04	10	64	2	24469399
Pubmed	EGLN3 inhibition of NF-κB is mediated by prolyl hydroxylase-independent inhibition of IκB kinase γ ubiquitination.	RNF31 CHUK	1.81e-04	11	64	2	23732909
Pubmed	Transient microglial absence assists postmigratory cortical neurons in proper differentiation.	MAP2 IL6ST	1.81e-04	11	64	2	32242005
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	GAS2L1 INTS5 CLCN7 MYCBP2 UBR4 SCN5A GATA2 DISP2 SMG6	1.83e-04	1105	64	9	35748872
Pubmed	Tbx19, a tissue-selective regulator of POMC gene expression.	GATA2 PROP1	2.17e-04	12	64	2	11447259
Pubmed	Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.	RNF31 CHUK	2.17e-04	12	64	2	19136968
Pubmed	A shared vesicular carrier allows synaptic corelease of GABA and glycine.	MAP2 RIMS1	2.17e-04	12	64	2	16701208
Pubmed	Molecular basis of pituitary dysfunction in mouse and human.	GATA2 PROP1	2.17e-04	12	64	2	11420609
Pubmed	Neuronal Ig/Caspr recognition promotes the formation of axoaxonic synapses in mouse spinal cord.	CNTN5 CNTNAP2	2.17e-04	12	64	2	24411736
Pubmed	Tumour necrosis factor signalling in health and disease.	RNF31 CHUK	2.17e-04	12	64	2	30755793
Pubmed	Parkin regulates NF-κB by mediating site-specific ubiquitination of RIPK1.	RNF31 CHUK	2.17e-04	12	64	2	29955050
Pubmed	HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.	UBR4 DDB2	2.17e-04	12	64	2	17360488
Pubmed	HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex.	RNF31 CHUK	2.57e-04	13	64	2	20614026
Pubmed	CNTF/LIF/gp130 receptor complex signaling maintains a VZ precursor differentiation gradient in the developing ventral forebrain.	IL6ST CNTFR	2.99e-04	14	64	2	15634701
Pubmed	CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.	MAP2 NTRK2	3.45e-04	15	64	2	26503042
Pubmed	Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains.	RNF31 CHUK	3.45e-04	15	64	2	23986494
Pubmed	Three human ARX mutations cause the lissencephaly-like and mental retardation with epilepsy-like pleiotropic phenotypes in mice.	MAP2 ARX	3.45e-04	15	64	2	19605412
Pubmed	Type III neuregulin 1 regulates pathfinding of sensory axons in the developing spinal cord and periphery.	MAP2 NTRK2	3.45e-04	15	64	2	22028026
Pubmed	Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction.	RNF31 CHUK	3.45e-04	15	64	2	20005846
Pubmed	Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development.	MAP2 NTRK2	3.45e-04	15	64	2	24035762
Pubmed	Mutation of the 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Substrate-Docking Site in the Developing Brain Causes Microcephaly with Abnormal Brain Morphogenesis Independently of Akt, Leading to Impaired Cognition and Disruptive Behaviors.	MAP2 NTRK2	3.45e-04	15	64	2	27644329
Pubmed	Specification of neurotransmitter identity by Tal1 in thalamic nuclei.	ARX GATA2	3.93e-04	16	64	2	28685891
Pubmed	Distinct developmental origins and regulatory mechanisms for GABAergic neurons associated with dopaminergic nuclei in the ventral mesodiencephalic region.	GATA2 CORIN	3.93e-04	16	64	2	22627282
Pubmed	Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae.	DCHS1 PAX1	3.93e-04	16	64	2	27381226
Pubmed	Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.	RNF31 LUZP1	4.45e-04	17	64	2	12693554
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	KL MAP2 MYCBP2 RIMS1 JPH3	4.52e-04	347	64	5	17114649
Pubmed	Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis.	GATA2 PROP1	5.00e-04	18	64	2	10499586
Pubmed	Hedgehog signaling is required for pituitary gland development.	GATA2 PROP1	5.00e-04	18	64	2	11152636
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	MIA3 LMF2 MYCBP2 SYNE2 UBR4 SMARCB1 LARP4 LUZP1 DNM2	5.90e-04	1297	64	9	33545068
Pubmed	Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation.	MAP2 ARX	6.20e-04	20	64	2	17460091
Pubmed	Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells.	MAP2 CORIN	6.84e-04	21	64	2	17670789
Pubmed	Ascl1 and Helt act combinatorially to specify thalamic neuronal identity by repressing Dlxs activation.	ARX GATA2	6.84e-04	21	64	2	25512300
Pubmed	An Alternative Splicing Program for Mouse Craniofacial Development.	MAP2 SYNE2	6.84e-04	21	64	2	33013468
Pubmed	Gli3 repressor controls cell fates and cell adhesion for proper establishment of neurogenic niche.	IL6ST CNTFR	6.84e-04	21	64	2	25127137
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	RNF31 MYCBP2 UBR4	7.29e-04	95	64	3	29643511
Pubmed	βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function.	ARX DISP2	7.52e-04	22	64	2	26944677
Pubmed	Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac.	GATA2 IL6ST	7.52e-04	22	64	2	9324354
Pubmed	Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC.	RNF31 CHUK	7.52e-04	22	64	2	36098982
Pubmed	Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain.	ARX CORIN	7.52e-04	22	64	2	26542012
Pubmed	Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification.	GATA2 PROP1	7.52e-04	22	64	2	11807026
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	MYCBP2 SYNE2 SMG6 NIN	8.00e-04	225	64	4	12168954
Pubmed	DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.	MED16 SMARCB1 DDB2	8.22e-04	99	64	3	34161765
Pubmed	Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development.	GATA2 PROP1	8.23e-04	23	64	2	10588713
Pubmed	Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS.	CLCN7 MYCBP2 LARP4 LUZP1	8.40e-04	228	64	4	30471916
Pubmed	Proximity interactions among centrosome components identify regulators of centriole duplication.	MYCBP2 USP54 NIN	8.71e-04	101	64	3	24613305
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	MAP2 RIMS1 LUZP1 JPH3	8.82e-04	231	64	4	16452087
Pubmed	Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems.	GATA2 SOX8	8.96e-04	24	64	2	17537790
Pubmed	OTUB1 modulates c-IAP1 stability to regulate signalling pathways.	RNF31 UBR4	8.96e-04	24	64	2	23524849
Pubmed	The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.	MAP2 UBR4	8.96e-04	24	64	2	35179492
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	SPATA31D4 SPATA31D3 UBR4 SIRT4	9.10e-04	233	64	4	37704626
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MAP2 MYCBP2 MAP4K1 SYNE2 USP54 CDC25B LUZP1	1.01e-03	861	64	7	36931259
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	MIA3 MAP2 MYCBP2 NTRK2 UBR4 CNTNAP2 RIMS1 JPH3	1.13e-03	1139	64	8	36417873
Pubmed	Gata2 and Gata3 regulate the differentiation of serotonergic and glutamatergic neuron subtypes of the dorsal raphe.	GATA2 CORIN	1.14e-03	27	64	2	27789623
Cytoband	9q21.32	SPATA31D4 SPATA31D3	3.22e-04	19	64	2	9q21.32
Cytoband	3p21	UBA7 SCN5A	9.82e-04	33	64	2	3p21
Cytoband	10q11.22	FRMPD2 FRMPD2B	1.51e-03	41	64	2	10q11.22
Cytoband	Ensembl 112 genes in cytogenetic band chr9q21	SPATA31D4 SPATA31D3 NTRK2	2.75e-03	199	64	3	chr9q21
Cytoband	Ensembl 112 genes in cytogenetic band chr13q22	ACOD1 MYCBP2	3.43e-03	62	64	2	chr13q22
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_500	KIAA1549L MAP2 NTRK2 SYNE2 ARX CNTNAP2 LARP4 SIRT4 LUZP1 CNTFR	1.30e-06	493	61	10	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_1000	KIAA1549L MAP2 NTRK2 SYNE2 ARX CNTNAP2 SOX8 CDC25B LARP4 SIRT4 LUZP1 CNTFR	1.93e-05	983	61	12	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_500_k-means-cluster#5	KIAA1549L NTRK2 SYNE2 ARX LUZP1 CNTFR	5.36e-05	232	61	6	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_500_K5
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIAA1549L MAP2 NTRK2 CNTN5 PEG3 CNTNAP2 RIMS1	1.29e-08	198	63	7	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MIA3 NTRK2 PEG3 CNTNAP2 DISP2 CNTFR	3.01e-07	191	63	6	3387b95a3f2445c672d407922fdce3a91eabaef8
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MIA3 NTRK2 PEG3 CNTNAP2 DISP2 CNTFR	3.40e-07	195	63	6	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	Substantia_nigra-Neuronal-Inhibitory\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MYCBP2 PEG3 CNTNAP2 DISP2 RIMS1	6.62e-06	186	63	5	9d3efe2a4feea2bc205a7e45b9b9f9ed9b3609ce
ToppCell	Substantia_nigra-Neuronal\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MYCBP2 PEG3 CNTNAP2 DISP2 RIMS1	6.62e-06	186	63	5	3f889083fcffe516388e9b03a5e23af2010ced33
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MYCBP2 PEG3 CNTNAP2 DISP2 RIMS1	6.97e-06	188	63	5	b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MAP4K1 SYNE2 PHTF2 CDC25B IL6ST	8.75e-06	197	63	5	7c9df6025b9d168bd6d041c6cff1e87e08b11847
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIAA1549L MAP2 NTRK2 CNTNAP2 RIMS1	8.97e-06	198	63	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIAA1549L MAP2 PEG3 CNTNAP2 RIMS1	8.97e-06	198	63	5	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIAA1549L MAP2 PEG3 CNTNAP2 RIMS1	8.97e-06	198	63	5	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIAA1549L MAP2 PEG3 CNTNAP2 RIMS1	8.97e-06	198	63	5	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	KIAA1549L MAP2 MYCBP2 CNTNAP2 RIMS1	9.41e-06	200	63	5	48d801219bc771d6c7e151dc88ca4c179988de85
Drug	euxanthone	MAP2 PEG3 ZIM2	6.52e-06	14	61	3	CID005281631
Drug	Pramoxine hydrochloride [637-58-1]; Down 200; 12.2uM; PC3; HT_HG-U133A	GAS2L1 CLCN7 MAP2 MED16 IL6ST SMG6	1.22e-05	191	61	6	3811_DN
Drug	Diethylstilbestrol [56-53-1]; Down 200; 15uM; PC3; HT_HG-U133A	LMF2 CLCN7 MED16 CNTNAP2 PHTF2 DNM2	1.37e-05	195	61	6	3812_DN
Drug	Thimerosal	GAS2L1 MIA3 MED16 MAP4K1 SYNE2 LRRC37A2 CNTNAP2 PHTF2 RIMS1 SOX8 LARP4 LUZP1 JPH3	1.39e-05	1199	61	13	ctd:D013849
Drug	Paclitaxel [33069-62-4]; Down 200; 4.6uM; PC3; HG-U133A	MIA3 MED16 GATA2 PHTF2 LARP4 IL6ST	1.41e-05	196	61	6	1959_DN
Drug	Epirizole [18694-40-1]; Down 200; 17uM; HL60; HT_HG-U133A	INTS5 LMF2 CLCN7 GATA2 SMARCB1 DNM2	1.45e-05	197	61	6	1845_DN
Drug	SC-58125; Up 200; 10uM; MCF7; HG-U133A	GAS2L1 LMF2 MED16 SCN5A PAX1 LUZP1	1.54e-05	199	61	6	254_UP
Drug	silicon cation	PEG3 ZIM2	7.02e-05	5	61	2	CID016019983
Drug	Etilefrine hydrochloride [534-87-2]; Up 200; 18.4uM; HL60; HT_HG-U133A	CLCN7 MAP4K1 UBR4 HBP1 SIRT4	1.25e-04	181	61	5	2930_UP
Drug	LY 294002; Up 200; 10uM; MCF7; HT_HG-U133A	NTRK2 CNTN5 PEG3 CNTNAP2 HBP1	1.49e-04	188	61	5	5596_UP
Drug	LIGA20	NTRK2 IL6ST CNTFR	1.56e-04	39	61	3	CID006441213
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A	MAP2 CNTNAP2 SIRT4 LUZP1 SMG6	1.60e-04	191	61	5	4302_UP
Drug	Beta-Escin [11072-93-8]; Down 200; 3.2uM; MCF7; HT_HG-U133A	CLCN7 MAP2 MED16 SIRT4 SMG6	1.60e-04	191	61	5	3890_DN
Drug	Trimethylsilyl	KL UBA7 HBP1	1.68e-04	40	61	3	CID000123362
Drug	Furaltadone hydrochloride [3759-92-0]; Down 200; 11uM; MCF7; HT_HG-U133A	LMF2 MED16 PHTF2 IL6ST CNTFR	1.72e-04	194	61	5	3932_DN
Drug	Nystatine [1400-61-9]; Up 200; 4.4uM; PC3; HT_HG-U133A	KL CLCN7 CNTNAP2 MUC16 SIRT4	1.72e-04	194	61	5	4223_UP
Drug	Pirenperone [ 75444-65-4]; Down 200; 10.2uM; MCF7; HT_HG-U133A	MIA3 LMF2 CLCN7 MED16 SMARCB1	1.72e-04	194	61	5	3316_DN
Drug	Fludrocortisone acetate [514-36-3]; Up 200; 9.4uM; PC3; HT_HG-U133A	KIAA1549L ZIM2 RIMS1 CNTFR JPH3	1.72e-04	194	61	5	3785_UP
Drug	estradiol, USP; Up 200; 0.1uM; MCF7; HT_HG-U133A	LMF2 CLCN7 MAP2 MED16 IL6ST	1.77e-04	195	61	5	5205_UP
Drug	Desipramine hydrochloride [58-28-6]; Up 200; 13.2uM; MCF7; HT_HG-U133A	KIAA1549L NTRK2 PHTF2 SIRT4 SMG6	1.77e-04	195	61	5	3212_UP
Drug	Flavoxate hydrochloride [3717-88-2]; Down 200; 9.4uM; MCF7; HT_HG-U133A	CLCN7 MED16 NTRK2 PHTF2 LUZP1	1.77e-04	195	61	5	5427_DN
Drug	Clorsulon [60200-06-8]; Down 200; 10.6uM; MCF7; HT_HG-U133A	UBA7 MED16 CNTNAP2 SIRT4 IL6ST	1.77e-04	195	61	5	2884_DN
Drug	BW-B 70C; Down 200; 31.6uM; MCF7; HT_HG-U133A_EA	GAS2L1 INTS5 GATA2 PHTF2 CDC25B	1.77e-04	195	61	5	1132_DN
Drug	Aspartic acid, N-acetyl (R,S) [997-55-7]; Down 200; 22.8uM; MCF7; HT_HG-U133A	CLCN7 MED16 NTRK2 IL6ST DNM2	1.81e-04	196	61	5	4125_DN
Drug	PHA-00745360 [351320-33-7]; Up 200; 10uM; PC3; HT_HG-U133A	CLCN7 MED16 CNTNAP2 ZIM2 SIRT4	1.85e-04	197	61	5	4559_UP
Drug	(1)-Nipecotic acid [498-95-3]; Up 200; 31uM; MCF7; HT_HG-U133A	LMF2 MED16 RIMS1 SIRT4 JPH3	1.85e-04	197	61	5	6500_UP
Drug	Zomepirac sodium salt [64092-48-4]; Down 200; 12.8uM; MCF7; HT_HG-U133A	LMF2 CLCN7 MED16 GATA2 LUZP1	1.85e-04	197	61	5	6815_DN
Drug	Rapamycin; Down 200; 0.1uM; HL60; HT_HG-U133A	GAS2L1 LMF2 MAP4K1 WDR25 IL6ST	1.85e-04	197	61	5	6167_DN
Drug	Ampyrone [83-07-8]; Up 200; 19.6uM; PC3; HT_HG-U133A	CLCN7 MED16 NTRK2 PEG3 SMG6	1.85e-04	197	61	5	4507_UP
Drug	Adrenosterone [382-45-6]; Up 200; 13.4uM; MCF7; HT_HG-U133A	UBA7 LMF2 MED16 LUZP1 SMG6	1.90e-04	198	61	5	5464_UP
Drug	Ofloxacin [82419-36-1]; Down 200; 11uM; PC3; HT_HG-U133A	RNF31 MED16 PHTF2 LUZP1 DNM2	1.90e-04	198	61	5	7372_DN
Drug	Carbetapentane citrate [23142-01-0]; Up 200; 7.6uM; MCF7; HT_HG-U133A	UBA7 MED16 MAP4K1 PEG3 SMG6	1.90e-04	198	61	5	2623_UP
Drug	estradiol, USP; Up 200; 0.1uM; PC3; HT_HG-U133A	NTRK2 PHTF2 WDR25 SIRT4 IL6ST	1.90e-04	198	61	5	1208_UP
Drug	PF-01378883-00 [351320-41-7]; Down 200; 10uM; MCF7; HT_HG-U133A	CLCN7 MAP4K1 NTRK2 HBP1 PAX1	1.90e-04	198	61	5	6363_DN
Drug	Minaprine dihydrochloride [25953-17-7]; Up 200; 10.8uM; PC3; HT_HG-U133A	UBA7 MAP2 NTRK2 CNTNAP2 CNTFR	1.90e-04	198	61	5	4230_UP
Drug	Azapropazone [13539-59-8]; Up 200; 13.4uM; MCF7; HT_HG-U133A	MED16 CNTNAP2 RIMS1 JPH3 SMG6	1.90e-04	198	61	5	6522_UP
Drug	Boldine [476-70-0]; Down 200; 12.2uM; PC3; HT_HG-U133A	INTS5 UBA7 LMF2 CLCN7 CNTNAP2	1.90e-04	198	61	5	4004_DN
Drug	Oxytetracycline dihydrate [6153-64-6]; Up 200; 8uM; MCF7; HT_HG-U133A	MIA3 UBA7 LMF2 NTRK2 RIMS1	1.90e-04	198	61	5	3170_UP
Drug	Cyclacillin [3485-14-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	CLCN7 MAP2 SIRT4 LUZP1 SMG6	1.90e-04	198	61	5	3882_DN
Drug	H-7 dihydrochloride; Up 200; 100uM; PC3; HT_HG-U133A	GAS2L1 CNTN5 CNTNAP2 PHTF2 IL6ST	1.94e-04	199	61	5	5968_UP
Drug	PF-00539758-00 [351321-34-1]; Down 200; 10uM; MCF7; HT_HG-U133A	MAP2 NTRK2 UBR4 CNTNAP2 RIMS1	1.94e-04	199	61	5	6416_DN
Drug	Methiothepin maleate [19728-88-2]; Up 200; 8.4uM; PC3; HT_HG-U133A	UBA7 KIAA1549L CLCN7 WDR25 SMG6	1.94e-04	199	61	5	6312_UP
Drug	Cloxacillin sodium salt [642-78-4]; Down 200; 8.8uM; MCF7; HT_HG-U133A	CLCN7 ZIM2 PHTF2 IL6ST JPH3	1.94e-04	199	61	5	2289_DN
Drug	Retrorsine [480-54-6]; Up 200; 11.4uM; MCF7; HT_HG-U133A	MIA3 KIAA1549L CLCN7 ZIM2 SIRT4	1.94e-04	199	61	5	4946_UP
Drug	Sulfamethazine sodium salt [1981-58-4]; Down 200; 13.4uM; PC3; HT_HG-U133A	MED16 CNTNAP2 WDR25 SIRT4 IL6ST	1.99e-04	200	61	5	3765_DN
Drug	PF-00562151-00 [351320-12-2]; Down 200; 10uM; MCF7; HT_HG-U133A	GAS2L1 CLCN7 NTRK2 PHTF2 SMG6	1.99e-04	200	61	5	5917_DN
Drug	Pralidoxime chloride [51-15-0]; Up 200; 23.2uM; PC3; HT_HG-U133A	UBA7 NTRK2 PAX1 IL6ST CNTFR	1.99e-04	200	61	5	6283_UP
Drug	Sparteine (-) [90-39-1]; Up 200; 17uM; HL60; HT_HG-U133A	MAP4K1 UBR4 RIMS1 WDR25 IL6ST	1.99e-04	200	61	5	2134_UP
Drug	Enilconazole [35554-44-0]; Up 200; 13.4uM; MCF7; HT_HG-U133A	LMF2 CNTNAP2 CNTFR JPH3 SMG6	1.99e-04	200	61	5	6518_UP
Drug	T-Pg	SCN5A HBP1 SMG6	2.09e-04	43	61	3	CID006323525
Drug	cytokinin	KL HBP1 CDC25B NIN	2.18e-04	110	61	4	CID000003830
Drug	AC1O1J2W	PEG3 ZIM2 MOCOS	2.24e-04	44	61	3	CID006122347
Disease	glycosyl ceramide (d18:1/20:0, d16:1/22:0) measurement	SYNE2 CORIN	9.06e-05	7	62	2	EFO_0800551
Disease	pancreatic hormone measurement	FRMPD2 FRMPD2B	1.93e-04	10	62	2	EFO_0020621
Disease	putamen volume change measurement	CNTNAP2 DCHS1	3.34e-04	13	62	2	EFO_0021495
Disease	major depressive disorder (is_implicated_in)	NTRK2 CNTNAP2	5.79e-04	17	62	2	DOID:1470 (is_implicated_in)
Disease	Colorectal Carcinoma	KL MAP2 FRMPD2 PEG3 DCHS1 IL6ST JPH3	6.62e-04	702	62	7	C0009402
Disease	left ventricular structural measurement	CNTNAP2 SMARCB1 SMG6	8.54e-04	88	62	3	EFO_0008205
Disease	electrocardiography	MYCBP2 SCN5A CNTNAP2 SMARCB1 LUZP1 AMZ2	8.57e-04	530	62	6	EFO_0004327
Disease	Lewy Body Disease	MAP2 NTRK2	9.77e-04	22	62	2	C0752347
Disease	West Syndrome	NTRK2 ARX	1.16e-03	24	62	2	C0037769
Disease	brain ischemia (biomarker_via_orthology)	MAP2 SCN5A IL6ST	1.31e-03	102	62	3	DOID:2316 (biomarker_via_orthology)
Disease	caudate volume change measurement, age at assessment	NTRK2 CNTN5	1.47e-03	27	62	2	EFO_0008007, EFO_0021491
Disease	ceramide measurement	NTRK2 SYNE2 CNTNAP2 CORIN	1.52e-03	235	62	4	EFO_0010222
Disease	pancreas volume	FRMPD2 FRMPD2B	1.82e-03	30	62	2	EFO_0600045
Disease	aortic measurement	GATA2 DISP2 SOX8 SMG6	1.94e-03	251	62	4	EFO_0020865
Disease	temporal lobe epilepsy (biomarker_via_orthology)	MAP2 NTRK2	1.94e-03	31	62	2	DOID:3328 (biomarker_via_orthology)
Disease	Hyperkinesia, Generalized	NTRK2 CNTNAP2	2.07e-03	32	62	2	C0751217
Disease	Hyperkinesia	NTRK2 CNTNAP2	2.07e-03	32	62	2	C3887506

Protein segments in the cluster

Peptide	Gene	Start	Entry
WIHPSHPRSSQGTES	SMG6	856	Q86US8
EIAGHFSSTRHTPWP	ALKBH8	381	Q96BT7
ITLHSPSDWITSHPE	AMZ2	51	Q86W34
PSLPASHHSSLSWKG	DISP2	1351	A7MBM2
TATLSWSPAADNHSP	CNTN5	686	O94779
PSSWIGVFRNSSHHP	KLRC1	171	P26715
SWPGTHSAATHRSPH	MUC16	8811	Q8WXI7
PWLSHPSVEEASSAS	MUC16	9131	Q8WXI7
PHESEATASWVTHPA	MUC16	11341	Q8WXI7
SLAPGAHTHWFSIDP	DCHS1	511	Q96JQ0
PPDSWSSHSSHFPRE	LRRC37A2	56	A6NM11
PPESWSSHSSHFPRE	LRRC37A	56	A6NMS7
AWLPPTSAEHDHSLS	CHUK	681	O15111
VPFLHWEAPVTSHSL	CLCN7	611	P51798
THPSSTHALAEWASR	CDC25B	206	P30305
HSSGDWPVPQAHADT	MOCOS	491	Q96EN8
KWHSELSPTEGPHSA	KIAA1549L	26	Q6ZVL6
PKPDWAHTGSHSSEA	SLC9A3R2	121	Q15599
SLAWHPTHPSTVAVG	DDB2	116	Q92466
PVDDTWLQSASSHSP	DNM2	751	P50570
SSPPHSVHSFSDRDW	PEG3	151	Q9GZU2
DTEHPWDLHSIPSEH	MED16	66	Q9Y2X0
TWHSRETSPISSHPV	RIMS1	571	Q86UR5
INSHATEWSPSHPGE	MTFR1	56	Q15390
TAGHVSIPRSWPSAH	PAX1	276	P15863
SAAAAHHHNPWTVSP	GATA2	106	P23769
PDPSKSHIAQWSPHT	IL6ST	656	P40189
WASSLTHSPESHPHL	FRMPD2B	256	Q6IN97
HALHSVTPRAEPDSW	GAS2L1	666	Q99501
TQSSPEPHWSTLTHS	FRMPD2	241	Q68DX3
AAHATPWTEEPRHLT	CNTFR	296	P26992
TAHPDQHVPAWTTDA	CORIN	111	Q9Y5Q5
SHAPPAETIRWKSHS	LUZP1	891	Q86V48
SSWHEIAATSGAHPE	LARP4	41	Q71RC2
PHHPALDSAWTAAAA	ARX	421	Q96QS3
SMDFDDTWHPATHPS	ACOD1	91	A6NK06
GASIWDTFTHHPLAP	KL	86	Q9UEF7
SSSSKSEPAFPHHHW	HBP1	156	O60381
LSPMSSATDPWHLDH	CNTNAP2	1221	Q9UHC6
SATDPWHLDHLDSAS	CNTNAP2	1226	Q9UHC6
SSPHLTAHSEPSLWN	MAP4K1	446	Q92918
DDPFHQSHLPWLHSS	PHTF2	441	Q8N3S3
KSISDGHSWHVPDSP	SYNE2	6446	Q8WXH0
AAEPEDDSFHWTPHT	MIA3	896	Q5JRA6
DDSFHWTPHTSVEPG	MIA3	901	Q5JRA6
AALGPHTHSPWFTSL	LMF2	511	Q9BU23
KSWAPEIATHPSGLH	NIN	1816	Q8N4C6
SWKESESEHHPSPDS	SSMEM1	161	Q8WWF3
AGESESHHTSLLVPW	SCN5A	551	Q14524
FSSHQPNPAHWALST	SIRT4	116	Q9Y6E7
WVPTLPNSSHHLDAV	SMARCB1	131	Q12824
FWGLPSLHSESLHPT	SPATA31D4	501	Q6ZUB0
HDILWHFVASLTPAP	MYCBP2	3591	O75592
WAHKSAPSASASPTE	SOX8	316	P57073
ASRHPDTTHSPWHLE	INTS5	891	Q6P9B9
FLESPTSDHHWCIPF	NTRK2	291	Q16620
SLSSPNPASAHLPWH	RNF31	291	Q96EP0
AIGDAWSHLPHFSSP	SPG11	1171	Q96JI7
FWGLPSLHSESLHPT	SPATA31D3	501	P0C874
TPTHPWTRSTDHTAV	SPEM3	221	A0A1B0GUW6
WTRSTDHTAVHTPAH	SPEM3	226	A0A1B0GUW6
HTPAHSWTHSKARTP	SPEM3	236	A0A1B0GUW6
SDPQHWLSRHTEAAP	SARG	316	Q9BW04
VGSLTLHDPHPTCWS	UBA7	56	P41226
IPVPHSSDTHSVAWL	TONSL	946	Q96HA7
GPHALTWTTHFSPSV	UNQ5815/PRO19632	61	Q6UWF5
ALSHQSEDWYPTLHP	PROP1	186	O75360
APHWTSAPLTEASAH	MAP2	11	P11137
SPPHSVHSFSGDRDW	ZIM2	26	Q9NZV7
SLWTSHVPASHMPLA	WDR25	116	Q64LD2
ENWSKHFSSDAVPHP	UBR4	916	Q5T4S7
TEKNSHHSWEPLDAP	USP54	981	Q70EL1
VPHTQSWSDLFHSPS	USP54	1581	Q70EL1
SWSDLFHSPSHPPIV	USP54	1586	Q70EL1
TESPPVFTWTSHHRA	JPH3	576	Q8WXH2