Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	MKRN3 MYCBP2 MKRN1 UBR3 XIAP NEURL4 WDR24	2.45e-04	372	67	7	GO:0061630
GeneOntologyMolecularFunction	endopeptidase inhibitor activity	SPINT3 XIAP ROCK1 RENBP ITIH4	3.46e-04	180	67	5	GO:0004866
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	MKRN3 MYCBP2 MKRN1 UBR3 XIAP NEURL4 WDR24	3.69e-04	398	67	7	GO:0061659
GeneOntologyMolecularFunction	potassium:chloride symporter activity	SLC12A4 SLC12A7	3.93e-04	9	67	2	GO:0015379
GeneOntologyMolecularFunction	peptidase inhibitor activity	SPINT3 XIAP ROCK1 RENBP ITIH4	4.12e-04	187	67	5	GO:0030414
GeneOntologyMolecularFunction	endopeptidase regulator activity	SPINT3 XIAP ROCK1 RENBP ITIH4	5.73e-04	201	67	5	GO:0061135
GeneOntologyMolecularFunction	ammonium channel activity	SLC12A4 SLC12A7	7.16e-04	12	67	2	GO:0008519
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	MKRN3 MYCBP2 MKRN1 UBR3 XIAP NEURL4 WDR24	1.02e-03	473	67	7	GO:0004842
GeneOntologyMolecularFunction	natural killer cell lectin-like receptor binding	PTPN6 HLA-E	1.46e-03	17	67	2	GO:0046703
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	MKRN3 MYCBP2 MKRN1 UBR3 XIAP NEURL4 WDR24	1.61e-03	512	67	7	GO:0019787
GeneOntologyMolecularFunction	peptidase regulator activity	SPINT3 XIAP ROCK1 RENBP ITIH4	1.71e-03	257	67	5	GO:0061134
Domain	Gal_Oxidase_b-propeller	KLHL11 KLHL1 KLHL18 KLHL17	6.47e-06	34	67	4	IPR015916
Domain	MKRN1_C	MKRN3 MKRN1	1.27e-05	2	67	2	PF15815
Domain	MKRN1_C	MKRN3 MKRN1	1.27e-05	2	67	2	IPR031644
Domain	zf-RNPHF	HNRNPH1 HNRNPH2	3.79e-05	3	67	2	PF08080
Domain	Znf_CHHC	HNRNPH1 HNRNPH2	3.79e-05	3	67	2	IPR012996
Domain	Kelch	KLHL11 KLHL1 KLHL18 KLHL17	5.55e-05	58	67	4	SM00612
Domain	Gal_Oxase/kelch_b-propeller	KLHL11 KLHL1 KLHL18 KLHL17	5.93e-05	59	67	4	IPR011043
Domain	BACK	KLHL11 KLHL1 KLHL18 KLHL17	6.34e-05	60	67	4	SM00875
Domain	BACK	KLHL11 KLHL1 KLHL18 KLHL17	6.77e-05	61	67	4	PF07707
Domain	BACK	KLHL11 KLHL1 KLHL18 KLHL17	6.77e-05	61	67	4	IPR011705
Domain	KCL_cotranspt	SLC12A4 SLC12A7	7.57e-05	4	67	2	IPR000076
Domain	Kelch_1	KLHL11 KLHL1 KLHL18 KLHL17	1.16e-04	70	67	4	PF01344
Domain	Kelch_1	KLHL11 KLHL1 KLHL18 KLHL17	1.16e-04	70	67	4	IPR006652
Domain	-	KLHL1 KLHL18 KLHL17	1.21e-04	27	67	3	2.130.10.80
Domain	EGF_LAM_2	CELSR1 LAMA5 STAB1	1.67e-04	30	67	3	PS50027
Domain	EGF_LAM_1	CELSR1 LAMA5 STAB1	1.67e-04	30	67	3	PS01248
Domain	EGF	CELSR1 SCUBE2 LAMA5 TECTA LTBP4 STAB1	1.96e-04	235	67	6	SM00181
Domain	Growth_fac_rcpt_	CELSR1 SCUBE2 LAMA5 LTBP4 STAB1	2.43e-04	156	67	5	IPR009030
Domain	SLC12A_fam	SLC12A4 SLC12A7	2.63e-04	7	67	2	IPR004842
Domain	Laminin_EGF	CELSR1 LAMA5 STAB1	2.66e-04	35	67	3	PF00053
Domain	EGF_Lam	CELSR1 LAMA5 STAB1	2.66e-04	35	67	3	SM00180
Domain	EGF-like_dom	CELSR1 SCUBE2 LAMA5 TECTA LTBP4 STAB1	2.67e-04	249	67	6	IPR000742
Domain	Laminin_EGF	CELSR1 LAMA5 STAB1	3.40e-04	38	67	3	IPR002049
Domain	6hp_glycosidase	SPATA20 RENBP	3.50e-04	8	67	2	IPR012341
Domain	SLC12_C	SLC12A4 SLC12A7	3.50e-04	8	67	2	IPR018491
Domain	-	SPATA20 RENBP	3.50e-04	8	67	2	1.50.10.10
Domain	SLC12	SLC12A4 SLC12A7	3.50e-04	8	67	2	PF03522
Domain	EGF_3	SCUBE2 STAB1	8.18e-04	12	67	2	PF12947
Domain	EGF_dom	SCUBE2 STAB1	8.18e-04	12	67	2	IPR024731
Domain	6-hairpin_glycosidase-like	SPATA20 RENBP	9.64e-04	13	67	2	IPR008928
Domain	EGF_CA	CELSR1 SCUBE2 LTBP4 STAB1	9.67e-04	122	67	4	SM00179
Domain	EGF-like_Ca-bd_dom	CELSR1 SCUBE2 LTBP4 STAB1	1.03e-03	124	67	4	IPR001881
Domain	VWA	ANTXR1 ITGAL ITIH4	1.07e-03	56	67	3	PF00092
Domain	EGF	CELSR1 SCUBE2 TECTA STAB1	1.09e-03	126	67	4	PF00008
Domain	ConA-like_dom	PAPPA2 CELSR1 LAMA5 NEURL4 DDX1	1.13e-03	219	67	5	IPR013320
Domain	BTB	KLHL11 KLHL1 KLHL18 KLHL17	1.26e-03	131	67	4	PF00651
Domain	EGF_1	CELSR1 SCUBE2 LAMA5 LTBP4 STAB1	2.21e-03	255	67	5	PS00022
Domain	EGF-like_CS	CELSR1 SCUBE2 LAMA5 LTBP4 STAB1	2.45e-03	261	67	5	IPR013032
Domain	EGF_2	CELSR1 SCUBE2 LAMA5 LTBP4 STAB1	2.61e-03	265	67	5	PS01186
Domain	BTB	KLHL11 KLHL1 KLHL18 KLHL17	2.61e-03	160	67	4	PS50097
Domain	AA-permease/SLC12A_dom	SLC12A4 SLC12A7	2.80e-03	22	67	2	IPR004841
Domain	AA_permease	SLC12A4 SLC12A7	2.80e-03	22	67	2	PF00324
Domain	-	MYCBP2 TECPR1	2.80e-03	22	67	2	2.130.10.30
Domain	RCC1/BLIP-II	MYCBP2 TECPR1	3.06e-03	23	67	2	IPR009091
Domain	VWFA	ANTXR1 ITGAL ITIH4	3.19e-03	82	67	3	PS50234
Domain	VWA	ANTXR1 ITGAL ITIH4	3.42e-03	84	67	3	SM00327
Domain	ZF_RING_1	MKRN3 MYCBP2 MKRN1 UBR3 XIAP	3.90e-03	291	67	5	PS00518
Domain	BTB	KLHL11 KLHL1 KLHL18 KLHL17	3.99e-03	180	67	4	SM00225
Domain	Homeobox_metazoa	HOXC11 HOXD8 TLX1	4.15e-03	90	67	3	IPR020479
Domain	ZF_RING_2	MKRN3 MYCBP2 MKRN1 UBR3 XIAP	4.31e-03	298	67	5	PS50089
Domain	BTB/POZ_dom	KLHL11 KLHL1 KLHL18 KLHL17	4.39e-03	185	67	4	IPR000210
Domain	SKP1/BTB/POZ	KLHL11 KLHL1 KLHL18 KLHL17	4.74e-03	189	67	4	IPR011333
Domain	-	PAPPA2 CELSR1 LAMA5	4.83e-03	95	67	3	2.60.120.200
Domain	VWF_A	ANTXR1 ITGAL ITIH4	5.41e-03	99	67	3	IPR002035
Domain	ASX_HYDROXYL	CELSR1 SCUBE2 LTBP4	5.57e-03	100	67	3	PS00010
Domain	Znf_RING	MKRN3 MYCBP2 MKRN1 UBR3 XIAP	6.27e-03	326	67	5	IPR001841
Domain	EGF-type_Asp/Asn_hydroxyl_site	CELSR1 SCUBE2 LTBP4	6.54e-03	106	67	3	IPR000152
Domain	RRM_1	RBMXL2 RBMXL3 HNRNPH1 HNRNPH2	6.63e-03	208	67	4	PF00076
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PTPN6 DNAJC13 MTMR11 SLC12A4 TIAM1 MYCBP2 UBR3 ROCK1 PEAK1 SLC12A7 USP1 NEURL4	9.64e-07	1049	69	12	27880917
Pubmed	Update on the Kelch-like (KLHL) gene family.	KLHL11 KLHL1 KLHL18 KLHL17	1.36e-06	41	69	4	23676014
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TAOK2 CELSR1 FOXK2 SLC12A4 MYCBP2 LRP3 LAMA5 SPATA20 LTBP4 ANO8 WDR24 KLHL17	1.66e-06	1105	69	12	35748872
Pubmed	Haploinsufficiency of the germ cell-specific nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in the mouse.	RBMXL2 RBMXL3	3.88e-06	2	69	2	18562473
Pubmed	An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning.	RBMXL2 RBMXL3	3.88e-06	2	69	2	30674417
Pubmed	hnRNPs H, H' and F behave differently with respect to posttranslational cleavage and subcellular localization.	HNRNPH1 HNRNPH2	1.16e-05	3	69	2	10456323
Pubmed	Heterogeneous nuclear ribonucleoproteins F and H/H' show differential expression in normal and selected cancer tissues.	HNRNPH1 HNRNPH2	1.16e-05	3	69	2	14980514
Pubmed	A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.	SLC12A4 SLC12A7	1.16e-05	3	69	2	11551954
Pubmed	Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells.	SLC12A4 SLC12A7	1.16e-05	3	69	2	15262997
Pubmed	Heterogeneous nuclear ribonucleoprotein H1/H2-dependent unsplicing of thymidine phosphorylase results in anticancer drug resistance.	HNRNPH1 HNRNPH2	1.16e-05	3	69	2	21068389
Pubmed	Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes.	HNRNPH1 HNRNPH2	1.16e-05	3	69	2	7499401
Pubmed	K-Cl cotransporter gene expression during human and murine erythroid differentiation.	SLC12A4 SLC12A7	1.16e-05	3	69	2	21733850
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	KLHL11 CELSR1 ARSA MYCBP2 HLA-E LAMA5 ANTXR1 CHPF2 PLOD2 ERLEC1 DDX1	2.31e-05	1201	69	11	35696571
Pubmed	Excess SMAD signaling contributes to heart and muscle dysfunction in muscular dystrophy.	LTBP4 SMAD4	2.32e-05	4	69	2	25070948
Pubmed	Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts.	SLC12A4 SLC12A7	2.32e-05	4	69	2	12637262
Pubmed	A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.	KLHL11 KLHL1 KLHL18 KLHL17	2.79e-05	87	69	4	37495603
Pubmed	Hox11 expression characterizes developing zeugopod synovial joints and is coupled to postnatal articular cartilage morphogenesis into functional zones in mice.	HOXC11 TLX1	3.86e-05	5	69	2	34010606
Pubmed	A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins.	HNRNPH1 HNRNPH2	8.09e-05	7	69	2	31704785
Pubmed	Age-related expression analysis of mouse liver nuclear protein binding to 3'-untranslated region of Period2 gene.	HNRNPH1 HNRNPH2	8.09e-05	7	69	2	25846207
Pubmed	Hepatitis C virus infection protein network.	HOXD8 ITGAL LTBP4	8.12e-05	42	69	3	18985028
Pubmed	Nomenclature for human homeobox genes.	HOXC11 HOXD8 TLX1	9.34e-05	44	69	3	1973146
Pubmed	Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton.	HOXC11 TLX1	1.08e-04	8	69	2	12869760
Pubmed	Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition.	SLC12A4 SLC12A7	1.08e-04	8	69	2	11395011
Pubmed	The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.	SLC12A4 SLC12A7	1.08e-04	8	69	2	24393035
Pubmed	Similar effects of all WNK3 variants on SLC12 cotransporters.	SLC12A4 SLC12A7	1.08e-04	8	69	2	21613606
Pubmed	Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).	SLC12A4 SLC12A7	1.08e-04	8	69	2	12386165
Pubmed	Vertebrate homeobox gene nomenclature.	HOXC11 HOXD8 TLX1	1.14e-04	47	69	3	1358459
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	MYCBP2 MKRN1 LAMA5 HAGH LTBP4 HNRNPH2 STAB1	1.23e-04	560	69	7	21653829
Pubmed	Cation-chloride cotransporters and neuronal function.	SLC12A4 SLC12A7	1.38e-04	9	69	2	19323993
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	FOXK2 MYCBP2 XIAP RIMBP2 OGA USP1 NEURL4 KLHL18 WDR24	1.62e-04	1005	69	9	19615732
Pubmed	Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system.	KLHL11 KLHL1 XIAP KLHL18	1.68e-04	138	69	4	28786561
Pubmed	Functional proteomics mapping of a human signaling pathway.	PAPPA2 MTMR11 SLC12A4 MYCBP2 LAMA5 ROCK1 SMAD4	1.71e-04	591	69	7	15231748
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	HLA-E HPS5 NEURL4 WDR24	1.73e-04	139	69	4	25476789
Pubmed	Structural and functional differences in the long non-coding RNA hotair in mouse and human.	HOXC11 HOXD8	1.73e-04	10	69	2	21637793
Pubmed	Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex.	HNRNPH1 HNRNPH2	2.11e-04	11	69	2	21900255
Pubmed	Loss of Zic3 impairs planar cell polarity leading to abnormal left-right signaling, heart defects and neural tube defects.	CELSR1 ROCK1	2.11e-04	11	69	2	34274973
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	LAMA5 CHPF2 PLOD2 LTBP4 ERLEC1 HNRNPH1 HNRNPH2	2.14e-04	613	69	7	22268729
Pubmed	Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development.	HDAC11 SMAD4	2.53e-04	12	69	2	17568773
Pubmed	A murine model of hnRNPH2-related neurodevelopmental disorder reveals a mechanism for genetic compensation by Hnrnph1.	HNRNPH1 HNRNPH2	2.53e-04	12	69	2	37463454
Pubmed	Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus.	HLA-E XIAP	2.53e-04	12	69	2	25902529
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	RBMXL3 MYCBP2 CHPF2 PLOD2 ERLEC1	2.61e-04	285	69	5	32838362
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	DNAJC13 FOXK2 TIAM1 MYCBP2 XIAP CFAP161 NEURL4 RSPH10B DDX1 WDR24	2.67e-04	1321	69	10	27173435
Pubmed	Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development.	CELSR1 LAMA5	2.98e-04	13	69	2	27789626
Pubmed	Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure.	CELSR1 ROCK1	2.98e-04	13	69	2	17229766
Pubmed	Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome.	TIAM1 SIM1	2.98e-04	13	69	2	8812055
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	HDAC11 MYCBP2 SERAC1 PLOD2 HNRNPH1 HNRNPH2	3.14e-04	462	69	6	31138677
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	LAMA5 CHPF2 PLOD2 ERLEC1	3.25e-04	164	69	4	32409323
Pubmed	An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape.	OGA TLX1	3.48e-04	14	69	2	23453598
Pubmed	The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation.	LAMA5 SMAD4	4.57e-04	16	69	2	19733164
Pubmed	Tandem immunoprecipitation approach to identify HIV-1 Gag associated host factors.	HNRNPH1 HNRNPH2	4.57e-04	16	69	2	24690621
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	GREB1L SLC12A4 SPATA20 PLOD2 LTBP4 NEURL4 HNRNPH1 SMAD4	4.85e-04	925	69	8	28986522
Pubmed	Executioner caspase-3 and caspase-7 are functionally distinct proteases.	XIAP ROCK1	5.18e-04	17	69	2	18723680
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	GREB1L KLHL1 TECTA KLHL18 ERLEC1 HNRNPH1	5.47e-04	513	69	6	25798074
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TAOK2 DNAJC13 MYCBP2 ROCK1 SPATA20 RIMBP2 NEURL4 ITIH4	6.31e-04	963	69	8	28671696
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	DNAJC13 FOXK2 MYCBP2 NEURL4 ERLEC1 NDUFV1	6.67e-04	533	69	6	25544563
Pubmed	gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules.	HLA-E ITGAL	7.20e-04	20	69	2	9263011
Pubmed	SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects.	CELSR1 ROCK1	7.20e-04	20	69	2	32511952
Pubmed	DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.	HNRNPH1 HNRNPH2 DDX1	7.51e-04	89	69	3	22446626
Pubmed	USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis.	MYCBP2 XIAP	7.95e-04	21	69	2	32839293
Pubmed	Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate.	PLOD2 ERLEC1	7.95e-04	21	69	2	23097496
Pubmed	Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs.	HOXC11 HOXD8	8.73e-04	22	69	2	26283362
Pubmed	CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP.	PTPN6 ROCK1	8.73e-04	22	69	2	34187934
Pubmed	Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex.	HNRNPH1 HNRNPH2	8.73e-04	22	69	2	18377426
Pubmed	Rare independent mutations in renal salt handling genes contribute to blood pressure variation.	SLC12A4 SLC12A7	8.73e-04	22	69	2	18391953
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	DNAJC13 SLC12A4 XIAP ROCK1 PLOD2	9.39e-04	378	69	5	34315543
Pubmed	A novel missense variant in CUL3 shows altered binding ability to BTB-adaptor proteins leading to diverse phenotypes of CUL3-related disorders.	KLHL11 KLHL18	9.55e-04	23	69	2	33130828
Pubmed	BDNF and NT4 play interchangeable roles in gustatory development.	XIAP ROCK1	9.55e-04	23	69	2	24378336
Pubmed	Proteomic dissection of the von Hippel-Lindau (VHL) interactome.	PLOD2 HNRNPH1 HNRNPH2	9.93e-04	98	69	3	21942715
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	DNAJC13 MYCBP2 LAMA5 ANTXR1 HAGH PLOD2 ERLEC1 NDUFV1 HNRNPH2	1.03e-03	1297	69	9	33545068
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	TAOK2 FOXK2 HNRNPH1 HNRNPH2 DDX1 SMAD4	1.06e-03	583	69	6	29844126
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	MYCBP2 HPS5 OGA STAB1	1.06e-03	225	69	4	12168954
Pubmed	Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.	MKRN3 UBR3 XIAP	1.21e-03	105	69	3	22493164
Pubmed	Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach.	HOXC11 LAMA5 LTBP4	1.25e-03	106	69	3	18654987
Pubmed	Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy.	TAOK2 SLC12A4 NDUFV1	1.25e-03	106	69	3	33087821
Pubmed	Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy.	HNRNPH1 HNRNPH2 DDX1	1.35e-03	109	69	3	29511296
Pubmed	Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1.	HNRNPH1 HNRNPH2 ITIH4 DDX1	1.37e-03	241	69	4	23125841
Pubmed	Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.	KLHL11 HNRNPH1 TECPR1	1.39e-03	110	69	3	27889896
Pubmed	Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.	HNRNPH1 DDX1	1.42e-03	28	69	2	38492217
Pubmed	Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.	TIAM1 ROCK1 LTBP4	1.42e-03	111	69	3	22558309
Pubmed	Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.	FOXK2 MYCBP2 OGA	1.61e-03	116	69	3	21282530
Pubmed	TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer.	ANTXR1 ROCK1	1.63e-03	30	69	2	34285210
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	METTL1 MYCBP2 PLOD2 HNRNPH1 HNRNPH2	1.83e-03	440	69	5	34244565
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	KLHL11 ANTXR1 CHPF2 HPS5 SLC12A7 DDX1	1.84e-03	650	69	6	38777146
Pubmed	Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome.	HNRNPH2 DDX1	1.85e-03	32	69	2	18809582
GeneFamily	Kelch like\|BTB domain containing	KLHL11 KLHL1 KLHL18 KLHL17	5.36e-06	42	50	4	617
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	KLHL11 KLHL1 KLHL18 KLHL17	5.10e-04	134	50	4	861
GeneFamily	RNA binding motif containing	RBMXL2 RBMXL3 HNRNPH1 HNRNPH2	2.82e-03	213	50	4	725
GeneFamily	HOXL subclass homeoboxes	HOXC11 HOXD8	9.10e-03	52	50	2	518
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K27ME3	CELSR1 RBMXL2 HOXC11 RBMXL3 HOXD8 SIM1 TLX1	9.45e-06	282	69	7	MM822
Coexpression	GSE17721_0.5H_VS_8H_PAM3CSK4_BMDC_UP	TIAM1 HLA-E HAGH SLC12A7 OGA SMAD4	1.47e-05	200	69	6	M4110
ToppCell	facs-Tongue-nan-3m-Epithelial-basal_cell_of_epidermis\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 SLC12A4 ANTXR1 LTBP4 HNRNPH1 HNRNPH2	6.41e-07	198	69	6	22559b161e67b49fe8028bfaf861e069063599f5
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_2\|390C / Donor, Lineage, Cell class and subclass (all cells)	MTMR11 SLC12A7 NEURL4 STAB1 KLHL17	4.28e-06	155	69	5	15bacd06cc2b02b13c85bb71c5b758e5ff613e80
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Hematologic-red_blood_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCUBE2 SAMD11 MKRN1 HAGH TECTA	5.80e-06	165	69	5	62dd54dfbec7f43a41546a1fec719545c2608a36
ToppCell	Basal\|World / shred by cell class for mouse tongue	CELSR1 SLC12A4 LAMA5 ANTXR1 LTBP4	9.59e-06	183	69	5	c6729a207526ff4aa48176207b9353176f631fea
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF18 HAGH USP1 LTBP4 STAB1	1.01e-05	185	69	5	87151ab95530e70d61328b336518df58db584acb
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-BM_CD8_+_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 PEAK1 ITGAL SLC12A7 TECPR1	1.04e-05	186	69	5	4dce1484653bb266e2305cbb306fb11eaf7892e2
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-mature_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 PEAK1 ITGAL SLC12A7 TECPR1	1.04e-05	186	69	5	e23e1246914e230369a716d0d666b98383bf8512
Disease	brain disease (implicated_via_orthology)	TIAM1 MYCBP2	7.35e-05	6	66	2	DOID:936 (implicated_via_orthology)
Disease	inter-alpha-trypsin inhibitor heavy chain h4 measurement	ITIH4 STAB1	1.03e-04	7	66	2	EFO_0020481
Disease	1-myristoyl-2-arachidonoyl-GPC (14:0/20:4) measurement	GREB1L ROCK1	3.21e-04	12	66	2	EFO_0800453
Disease	level of Phosphatidylcholine (16:1_18:1) in blood serum	GREB1L ROCK1	3.78e-04	13	66	2	OBA_2045082
Disease	Deaf Mutism	SERAC1 SMAD4	9.12e-04	20	66	2	C4082305
Disease	Deafness, Acquired	SERAC1 SMAD4	9.12e-04	20	66	2	C0751068
Disease	Hearing Loss, Extreme	SERAC1 SMAD4	9.12e-04	20	66	2	C0086395
Disease	Complete Hearing Loss	SERAC1 SMAD4	9.12e-04	20	66	2	C0581883
Disease	Prelingual Deafness	SERAC1 SMAD4	9.12e-04	20	66	2	C0011052
Disease	Bilateral Deafness	SERAC1 SMAD4	9.12e-04	20	66	2	C3665473
Disease	Deafness	SERAC1 SMAD4	1.43e-03	25	66	2	C0011053

Protein segments in the cluster

Peptide	Gene	Start	Entry
KEFLSGSYCFRGGVG	ERLEC1	336	Q96DZ1
RREDGGPACYGGFDL	ANTXR1	31	Q9H6X2
SDRGGGFCAYADITL	HDAC11	146	Q96DB2
REGGYTCECFEDFTG	CELSR1	1381	Q9NYQ6
LRYGQDFCLGITGGF	CFAP161	141	Q6P656
GGGTRGFSCEEDFIY	ANO8	136	Q9HCE9
VSGRYSLFCLGFGFD	ITIH4	406	Q14624
EGEGFAAFQGGCTYR	RSPH10B	96	P0C881
EGEGFAAFQGGCTYR	RSPH10B2	96	B2RC85
GGFFTCLGREGRVYD	RENBP	46	P51606
GCELGPDGRFLRGYE	HLA-E	121	P13747
TGCGGREGRGQEYFH	HOXD8	81	P13378
TGADICGFFGDAEYE	MGAM2	1506	Q2M2H8
GSDLLRCGGFYTASD	MTMR11	266	A4FU01
DAGGDFYLRCLGKNG	FOXK2	106	Q01167
GDTLFVAGCGKFYEG	HAGH	181	Q16775
GGCRFFGGTVTGLDF	KIAA1109	1131	Q2LD37
GNKERDGEYGACFFP	HPS5	211	Q9UPZ3
YDRGSAFAIGSDGLC	DDX1	96	Q92499
DGYGFGSDRFGRDLN	HNRNPH2	251	P55795
GSDRFGRDLNYCFSG	HNRNPH2	256	P55795
EGGRFCYPEFSSGEE	PEAK1	221	Q9H792
DLACGRRLGSFYGSF	LRP3	251	O75074
IFADDLGYGDLGCYG	ARSA	26	P15289
CKDGFFGLDQADYFG	LAMA5	811	O15230
DGYGFGSDRFGRDLN	HNRNPH1	251	P31943
GSDRFGRDLNYCFSG	HNRNPH1	256	P31943
GNCIGCGERGFRYFT	GREB1L	181	Q9C091
VGEDFQGGGCKFLRY	PLOD2	681	O00469
GYDGGDCRLQGRCYS	PAPPA2	606	Q9BXP8
GVSEGGDYLSECVGY	KLHL11	366	Q9NVR0
GLLYSAGGYDGASCL	KLHL17	436	Q6TDP4
VCGGYDGSGFLSIAE	KLHL18	481	O94889
DLSDYQGGFCILYGG	DNAJC13	161	O75165
FDRFFDNAYCGGGDP	HOXC11	151	O43248
SDASGFGYCFRELRG	LTBP4	281	Q8N2S1
RAGQGCFVSGLYLEG	DNAH10	4371	Q8IVF4
EFGGAVGLCFYLGTT	SLC12A7	196	Q9Y666
NRRCGGELGDFTGYI	SCUBE2	806	Q9NQ36
YGCDLDALGTGARIG	NEURL4	821	Q96JN8
RYFDEGRGSCPFGGN	MKRN1	371	Q9UHC7
YGDKDADGFYRGETC	RIMBP2	886	O15034
CFGGNGLPYAESFGE	SERAC1	251	Q96JX3
GARRFLCGVVEGFYG	OGA	56	O60502
ACGSGYDFDVFVVRG	NDUFV1	186	P49821
DGYVDPSGGDRFCLG	SMAD4	351	Q13485
ACEGGRCEAGRYFLG	SIM1	466	P81133
QGCGAVGDRGLFALY	TAOK2	1101	Q9UL54
FVGGLSGCGEYTRVF	SAMD11	551	Q96NU1
YFGGEARCDAEAGRG	MYCBP2	4551	O75592
IGSYFGGELCGVDVD	ITGAL	456	P20701
DCPLRGYSDRDGYGG	RBMXL2	251	O75526
EFGGAVGLCFYLGTT	SLC12A4	196	Q9UP95
GGRFDRQASAEGCFY	CHPF2	661	Q9P2E5
YCLAAGGGVFRTFDG	TECTA	1486	O75443
GFLYTGEGDTVRCFS	XIAP	51	P98170
GCTLFFYESDGRSGI	TIAM1	471	Q13009
RYFAEGRGNCPFGDT	MKRN3	401	Q13064
GGGGCYEEYRGRSLD	RBMXL3	586	Q8N7X1
FETGECELFAYGGCG	SPINT3	56	P49223
GGGYFCSEAELGAGL	SPATA20	616	Q8TB22
GCFFGDEVRGSGESA	TECPR1	396	Q7Z6L1
GGDGFSCYGDIFREL	STAB1	981	Q9NY15
CEGGRYTVGGLETFD	PTPN6	171	P29350
LKSQGGDGYYGRECD	ROCK1	246	Q13464
QDGEYGLGCLVGGAY	TLX1	41	P31314
CLLAGGGGYDEFCAA	UBR3	96	Q6ZT12
GGGYDEFCAAVRAYD	UBR3	101	Q6ZT12
RGFFTEDEPGCFGEG	ZNF18	326	P17022
EGLCYGLFGDLAFAA	WDR24	341	Q96S15
AQVEFADIGCGYGGL	METTL1	76	Q9UBP6
AASGLEFDCYGGGLS	USP1	536	O94782
RRGGVGVATCDGFLY	KLHL1	636	Q9NR64
CLLGDRLYAVGGYDG	KLHL1	696	Q9NR64