Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2C KMT2D KMT2A	2.69e-05	8	159	3	GO:0140945
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2C KMT2D KMT2A	5.71e-05	10	159	3	GO:0140999
GeneOntologyMolecularFunction	alkylglycerol kinase activity	DGKA DGKQ	1.88e-04	3	159	2	GO:0047649
GeneOntologyCellularComponent	CHD-type complex	CHD3 GATAD2B MTA1	2.77e-04	17	160	3	GO:0090545
GeneOntologyCellularComponent	NuRD complex	CHD3 GATAD2B MTA1	2.77e-04	17	160	3	GO:0016581
HumanPheno	Abnormality of calvarial morphology	COL5A1 HIC1 FRMPD4 SZT2 NELFA BICRA DHX37 APC2 KATNB1 NARS1 CHD3 RREB1 CHAMP1 GATAD2B FREM1 POLR3A HIRA KMT2C SNX14 SH3PXD2B KMT2D MOGS PIK3R1 PIK3R2 NPAP1 ANKRD11 PTCH2 KMT2A HERC1 SEC23A	1.94e-06	1134	60	30	HP:0002648
HumanPheno	Abnormal eyelid morphology	COL5A1 NDST1 HIC1 AFF2 SZT2 NELFA BICRA APC2 KATNB1 NARS1 CHD3 RREB1 CHAMP1 GATAD2B FREM1 POLR3A HIRA KMT2C SNX14 SH3PXD2B KMT2D MOGS PIK3R1 PIK3R2 IGHM NPAP1 ANKRD11 PTCH2 KMT2A MACF1 HERC1 CLP1 RIC1	6.56e-06	1408	60	33	HP:0000492
HumanPheno	Abnormal calvaria morphology	COL5A1 HIC1 FRMPD4 SZT2 NELFA BICRA DHX37 APC2 KATNB1 NARS1 CHD3 RREB1 CHAMP1 GATAD2B FREM1 POLR3A HIRA KMT2C SNX14 SH3PXD2B KMT2D MOGS PIK3R1 PIK3R2 NPAP1 ANKRD11 PTCH2 KMT2A HERC1 SEC23A	1.72e-05	1254	60	30	HP:0002683
HumanPheno	Abnormal palate morphology	COL5A1 DLG5 COL13A1 FRMPD4 NELFA BICRA APC2 CHD3 RREB1 CHAMP1 GATAD2B CHRNB1 POLR3A HIRA KMT2C SNX14 SH3PXD2B KMT2D MOGS PIK3R1 IGHM ANKRD11 PTCH2 KMT2A HAAO HERC1 CLP1 SEC23A RIC1	2.28e-05	1202	60	29	HP:0000174
HumanPheno	Abnormality of the palpebral fissures	COL5A1 SZT2 NELFA BICRA APC2 KATNB1 NARS1 RREB1 CHAMP1 GATAD2B FREM1 POLR3A HIRA KMT2C SNX14 SH3PXD2B KMT2D MOGS PIK3R2 NPAP1 ANKRD11 KMT2A HERC1 CLP1	2.43e-05	880	60	24	HP:0008050
HumanPheno	Abnormality of the dentition	COL5A1 NDST1 SZT2 NELFA DHX37 APC2 KATNB1 NARS1 CHD3 RREB1 GATAD2B FREM1 POLR3A HIRA KMT2C SNX14 SH3PXD2B KMT2D PIK3R1 NPAP1 ANKRD11 PTCH2 KMT2A CLP1 SEC23A RIC1	3.72e-05	1030	60	26	HP:0000164
HumanPheno	Epicanthus	COL5A1 NDST1 HIC1 AFF2 NELFA BICRA CHD3 RREB1 CHAMP1 GATAD2B HIRA SNX14 KMT2D PIK3R1 IGHM PTCH2 KMT2A MACF1 RIC1	4.46e-05	614	60	19	HP:0000286
HumanPheno	Wide nasal bridge	FRMPD4 NELFA APC2 KATNB1 CHD3 RREB1 GATAD2B FREM1 HIRA SNX14 SH3PXD2B KMT2D PIK3R1 PTCH2 KMT2A CLP1 SEC23A	4.79e-05	508	60	17	HP:0000431
HumanPheno	Hypertelorism	NELFA BICRA DHX37 KATNB1 NARS1 CHD3 RREB1 GATAD2B FREM1 POLR3A HIRA SH3PXD2B KMT2D PIK3R1 PIK3R2 IGHM ANKRD11 PTCH2 KMT2A MACF1 HERC1 SEC23A	9.93e-05	830	60	22	HP:0000316
HumanPheno	Atrial septal defect	DLG5 SZT2 NELFA BICRA APC2 KATNB1 CHD3 RREB1 POLR3A HIRA SNX14 SH3PXD2B KMT2D MOGS PIK3R2 KMT2A HAAO	1.06e-04	541	60	17	HP:0001631
HumanPheno	Abnormality of the atrial septum	DLG5 SZT2 NELFA BICRA APC2 KATNB1 CHD3 RREB1 POLR3A HIRA SNX14 SH3PXD2B KMT2D MOGS PIK3R2 KMT2A HAAO	1.06e-04	541	60	17	HP:0001630
HumanPheno	Abnormal nasal bridge morphology	FRMPD4 AFF2 NELFA BICRA APC2 KATNB1 CHD3 RREB1 GATAD2B FREM1 POLR3A HIRA SNX14 SH3PXD2B KMT2D PIK3R1 PIK3R2 NPAP1 ANKRD11 PTCH2 KMT2A MACF1 HERC1 CLP1 SEC23A	1.12e-04	1029	60	25	HP:0000422
HumanPheno	Abnormal atrial septum morphology	DLG5 SZT2 NELFA BICRA APC2 KATNB1 CHD3 RREB1 POLR3A HIRA SNX14 SH3PXD2B KMT2D MOGS PIK3R2 KMT2A HAAO	1.14e-04	544	60	17	HP:0011994
HumanPheno	Long toe	NELFA NARS1 RREB1 GATAD2B POLR3A HIRA PTCH2 KMT2A HERC1	1.30e-04	168	60	9	HP:0010511
HumanPheno	Abnormal cardiac septum morphology	DLG5 SZT2 NELFA BICRA APC2 PKD1L1 KATNB1 CHD3 RREB1 NDUFC2 POLR3A HIRA SNX14 SH3PXD2B KMT2D MOGS PIK3R2 ANKRD11 KMT2A HAAO MACF1	1.40e-04	787	60	21	HP:0001671
HumanPheno	Telecanthus	RREB1 HIRA SNX14 KMT2D PIK3R1 PIK3R2 ANKRD11 PTCH2 KMT2A	1.62e-04	173	60	9	HP:0000506
HumanPheno	Long palpebral fissure	GATAD2B KMT2D PIK3R2 ANKRD11 KMT2A CLP1	1.64e-04	71	60	6	HP:0000637
HumanPheno	Abnormal cardiac atrium morphology	DLG5 SZT2 NELFA BICRA APC2 PKD1L1 KATNB1 CHD3 RREB1 POLR3A HIRA SNX14 SH3PXD2B KMT2D MOGS PIK3R2 KMT2A HAAO	1.65e-04	617	60	18	HP:0005120
HumanPheno	Widely-spaced maxillary central incisors	GATAD2B FREM1 ANKRD11	1.76e-04	10	60	3	HP:0001566
HumanPheno	Long fingers	NELFA KATNB1 NARS1 RREB1 GATAD2B POLR3A HIRA KMT2C PTCH2 KMT2A HERC1 CLP1	1.83e-04	306	60	12	HP:0100807
HumanPheno	Kyphosis	COL13A1 NELFA APC2 NARS1 CHRNB1 POLR3A KMT2C SNX14 SH3PXD2B KMT2D MOGS PIK3R2 NPAP1 ANKRD11 HERC1 CLP1	1.84e-04	510	60	16	HP:0002808
HumanPheno	Tooth malposition	COL5A1 NDST1 KATNB1 NARS1 CHD3 GATAD2B FREM1 SNX14 SH3PXD2B KMT2D PIK3R1 ANKRD11 CLP1 RIC1	2.61e-04	418	60	14	HP:0000692
HumanPheno	Congenital malformation of the left heart	PKD1L1 POLR3A KMT2D ANKRD11 HAAO	2.97e-04	51	60	5	HP:0045017
HumanPheno	Hypoplasia of the corpus callosum	HIC1 FRMPD4 APC2 KATNB1 NARS1 POLR3A KMT2C SH3PXD2B KMT2D MOGS PIK3R2 NT5C2 ANKRD11 MACF1 CLP1	3.08e-04	478	60	15	HP:0002079
HumanPheno	Overfolded helix	BICRA NARS1 RREB1 FREM1 HIRA KMT2D	3.62e-04	82	60	6	HP:0000396
HumanPheno	Thoracic kyphosis	COL13A1 NARS1 CHRNB1 KMT2D MOGS PIK3R2 ANKRD11	3.97e-04	117	60	7	HP:0002942
HumanPheno	Central incisor gap	GATAD2B FREM1 ANKRD11	4.09e-04	13	60	3	HP:0001570
HumanPheno	Widely-spaced incisors	GATAD2B FREM1 ANKRD11	4.09e-04	13	60	3	HP:0006304
HumanPheno	Abnormality of dental eruption	NELFA APC2 POLR3A KMT2C SNX14 SH3PXD2B KMT2D PIK3R1 SEC23A RIC1	4.20e-04	240	60	10	HP:0006292
HumanPheno	Chronic otitis media	NELFA APC2 RREB1 HIRA KMT2D PIK3R1 IGHM ANKRD11	4.27e-04	156	60	8	HP:0000389
HumanPheno	Abnormal thoracic spine morphology	COL13A1 NARS1 CHRNB1 KMT2D MOGS PIK3R2 ANKRD11	4.41e-04	119	60	7	HP:0100711
HumanPheno	Scoliosis	COL5A1 COL13A1 NELFA BICRA DHX37 APC2 NARS1 CHD3 RREB1 CHRNB1 POLR3A HIRA KMT2C SNX14 SH3PXD2B KMT2D MOGS PIK3R2 NPAP1 ANKRD11 PTCH2 KMT2A HERC1 CLP1 SEC23A	4.69e-04	1122	60	25	HP:0002650
HumanPheno	Bulbous nose	BICRA KATNB1 RREB1 FREM1 HIRA SNX14 KMT2D KMT2A CLP1	4.98e-04	201	60	9	HP:0000414
HumanPheno	Abnormal conjugate eye movement	NDST1 COL13A1 FRMPD4 NELFA BICRA DHX37 ATCAY APC2 CHD3 RREB1 CHAMP1 GATAD2B POLR3A HIRA KMT2D PIK3R1 NPAP1 NT5C2 ANKRD11 PTCH2 KMT2A MACF1 CLP1 GMPPA SEC23A RIC1	5.15e-04	1198	60	26	HP:0000549
HumanPheno	Abnormal spaced incisors	GATAD2B FREM1 ANKRD11	5.16e-04	14	60	3	HP:0040159
HumanPheno	Frontal bossing	HIC1 FRMPD4 SZT2 NELFA BICRA NARS1 CHD3 GATAD2B POLR3A SNX14 SH3PXD2B KMT2D PIK3R1 PIK3R2 ANKRD11 PTCH2 KMT2A HERC1 SEC23A	5.31e-04	738	60	19	HP:0002007
HumanPheno	Autistic behavior	FRMPD4 AFF2 SZT2 BICRA APC2 COX10 CHD3 RREB1 NDUFC2 GATAD2B HIRA KMT2C SNX14 KMT2D NPAP1 ANKRD11 KMT2A CLP1	5.41e-04	678	60	18	HP:0000729
HumanPheno	Abnormal shape of the frontal region	HIC1 FRMPD4 SZT2 NELFA BICRA NARS1 CHD3 GATAD2B POLR3A SNX14 SH3PXD2B KMT2D PIK3R1 PIK3R2 ANKRD11 PTCH2 KMT2A HERC1 SEC23A	5.59e-04	741	60	19	HP:0011218
HumanPheno	Abnormal frontal bone morphology	HIC1 FRMPD4 SZT2 NELFA BICRA NARS1 CHD3 GATAD2B POLR3A SNX14 SH3PXD2B KMT2D PIK3R1 PIK3R2 ANKRD11 PTCH2 KMT2A HERC1 SEC23A	5.69e-04	742	60	19	HP:0430000
HumanPheno	Abnormality of the forehead	HIC1 COL13A1 FRMPD4 SZT2 NELFA BICRA APC2 KATNB1 NARS1 CHD3 GATAD2B FREM1 POLR3A SNX14 SH3PXD2B KMT2D PIK3R1 PIK3R2 NPAP1 ANKRD11 PTCH2 KMT2A HERC1 CLP1 GMPPA SEC23A	5.90e-04	1208	60	26	HP:0000290
HumanPheno	Facial hypertrichosis	NDST1 BICRA KATNB1 FREM1 POLR3A SNX14 ANKRD11 KMT2A CLP1	5.97e-04	206	60	9	HP:0002219
HumanPheno	Abnormally folded helix	BICRA NARS1 RREB1 FREM1 HIRA KMT2D	5.99e-04	90	60	6	HP:0008544
HumanPheno	Thoracic scoliosis	COL13A1 CHRNB1 KMT2D MOGS PIK3R2	6.37e-04	60	60	5	HP:0002943
HumanPheno	Enlarged cisterna magna	APC2 KATNB1 NDUFC2 SH3PXD2B CLP1	6.37e-04	60	60	5	HP:0002280
HumanPheno	Short philtrum	NELFA DHX37 RREB1 CHAMP1 GATAD2B FREM1 POLR3A HIRA SH3PXD2B GMPPA	6.38e-04	253	60	10	HP:0000322
HumanPheno	Abnormality of teeth spacing	COL5A1 NDST1 KATNB1 NARS1 CHD3 KMT2D CLP1	6.53e-04	127	60	7	HP:0006478
HumanPheno	Abnormality of the chin	NDST1 BICRA DHX37 APC2 CHAMP1 POLR3A SNX14 SH3PXD2B KMT2D PIK3R1 ANKRD11 PTCH2 HERC1	7.48e-04	409	60	13	HP:0000306
HumanPheno	Misalignment of incisors	GATAD2B FREM1 ANKRD11	7.80e-04	16	60	3	HP:0011062
HumanPheno	Strabismus	NDST1 COL13A1 FRMPD4 NELFA BICRA DHX37 ATCAY APC2 CHD3 RREB1 CHAMP1 GATAD2B HIRA KMT2D PIK3R1 NPAP1 NT5C2 ANKRD11 PTCH2 KMT2A MACF1 CLP1 GMPPA SEC23A RIC1	7.85e-04	1159	60	25	HP:0000486
MousePheno	abnormal eye size	NDST1 DLG5 DHRS3 SZT2 BICRA MINK1 KATNB1 FREM1 ABHD17C TGFBR3 SH3PXD2B ZIC5 MICAL2 SOX14	1.22e-05	375	132	14	MP:0002697
MousePheno	microphthalmia	NDST1 DLG5 DHRS3 SZT2 BICRA MINK1 KATNB1 FREM1 ABHD17C TGFBR3 ZIC5 MICAL2 SOX14	3.80e-05	362	132	13	MP:0001297
Domain	SH3	DLG5 ITSN1 BCAR1 PRAM1 SH3PXD2B SH3PXD2A PIK3R1 PIK3R2 MAP3K9 MACF1 FYB1	2.33e-06	216	158	11	PS50002
Domain	SH3_domain	DLG5 ITSN1 BCAR1 PRAM1 SH3PXD2B SH3PXD2A PIK3R1 PIK3R2 MAP3K9 MACF1 FYB1	2.79e-06	220	158	11	IPR001452
Domain	FYrich_C	KMT2C KMT2D KMT2A	5.87e-06	5	158	3	IPR003889
Domain	FYrich_N	KMT2C KMT2D KMT2A	5.87e-06	5	158	3	IPR003888
Domain	FYRC	KMT2C KMT2D KMT2A	5.87e-06	5	158	3	SM00542
Domain	FYRN	KMT2C KMT2D KMT2A	5.87e-06	5	158	3	SM00541
Domain	FYRN	KMT2C KMT2D KMT2A	5.87e-06	5	158	3	PF05964
Domain	FYRC	KMT2C KMT2D KMT2A	5.87e-06	5	158	3	PF05965
Domain	FYRC	KMT2C KMT2D KMT2A	5.87e-06	5	158	3	PS51543
Domain	FYRN	KMT2C KMT2D KMT2A	5.87e-06	5	158	3	PS51542
Domain	SH3	DLG5 ITSN1 BCAR1 PRAM1 SH3PXD2B SH3PXD2A PIK3R1 PIK3R2 MAP3K9 FYB1	1.57e-05	216	158	10	SM00326
Domain	NDUF_C2	NDUFC2-KCTD14 NDUFC2	7.11e-05	2	158	2	PF06374
Domain	NADH-UbQ_OxRdtase_b14.5b_su	NDUFC2-KCTD14 NDUFC2	7.11e-05	2	158	2	IPR009423
Domain	DUF4599	SPATA31D4 SPATA31D1 SPATA31D3	1.24e-04	12	158	3	PF15371
Domain	DUF4599	SPATA31D4 SPATA31D1 SPATA31D3	1.24e-04	12	158	3	IPR027970
Domain	hSH3	PRAM1 FYB1	2.12e-04	3	158	2	PF14603
Domain	PI3K_P85_iSH2	PIK3R1 PIK3R2	2.12e-04	3	158	2	IPR032498
Domain	hSH3	PRAM1 FYB1	2.12e-04	3	158	2	IPR029294
Domain	PI3K_P85_iSH2	PIK3R1 PIK3R2	2.12e-04	3	158	2	PF16454
Domain	Znf_FYVE_PHD	PHRF1 SPIRE1 CHD3 KMT2C KMT2D KMT2A BSN	2.57e-04	147	158	7	IPR011011
Domain	Post-SET_dom	KMT2C KMT2D KMT2A	3.07e-04	16	158	3	IPR003616
Domain	PostSET	KMT2C KMT2D KMT2A	3.07e-04	16	158	3	SM00508
Domain	POST_SET	KMT2C KMT2D KMT2A	3.07e-04	16	158	3	PS50868
Domain	SET	KMT2C KMT2D KMT2A PRDM6	3.91e-04	41	158	4	PF00856
Domain	PHD	PHRF1 CHD3 KMT2C KMT2D KMT2A	4.36e-04	75	158	5	PF00628
Domain	Znf_PHD-finger	PHRF1 CHD3 KMT2C KMT2D KMT2A	5.54e-04	79	158	5	IPR019787
Domain	SET	KMT2C KMT2D KMT2A PRDM6	6.10e-04	46	158	4	SM00317
Domain	FerI	OTOF FER1L5	6.99e-04	5	158	2	SM01202
Domain	FerB	OTOF FER1L5	6.99e-04	5	158	2	SM01201
Domain	Ferlin_B-domain	OTOF FER1L5	6.99e-04	5	158	2	IPR012561
Domain	TAFH	RUNX1T1 TAF4B	6.99e-04	5	158	2	SM00549
Domain	Ferlin_C	OTOF FER1L5	6.99e-04	5	158	2	PF16165
Domain	Ferlin_C	OTOF FER1L5	6.99e-04	5	158	2	IPR032362
Domain	FerIin_dom	OTOF FER1L5	6.99e-04	5	158	2	IPR012968
Domain	FerI	OTOF FER1L5	6.99e-04	5	158	2	PF08151
Domain	FerB	OTOF FER1L5	6.99e-04	5	158	2	PF08150
Domain	TAFH_NHR1	RUNX1T1 TAF4B	6.99e-04	5	158	2	IPR003894
Domain	PI3kinase_P85	PIK3R1 PIK3R2	6.99e-04	5	158	2	IPR001720
Domain	TAFH	RUNX1T1 TAF4B	6.99e-04	5	158	2	PS51119
Domain	TAFH	RUNX1T1 TAF4B	6.99e-04	5	158	2	PF07531
Domain	EPHD	KMT2C KMT2D KMT2A	8.13e-04	22	158	3	PS51805
Domain	SH3_2	ITSN1 SH3PXD2B PIK3R1 MAP3K9 FYB1	8.16e-04	86	158	5	PF07653
Domain	SH3_2	ITSN1 SH3PXD2B PIK3R1 MAP3K9 FYB1	8.16e-04	86	158	5	IPR011511
Domain	SET_dom	KMT2C KMT2D KMT2A PRDM6	8.39e-04	50	158	4	IPR001214
Domain	SET	KMT2C KMT2D KMT2A PRDM6	8.39e-04	50	158	4	PS50280
Domain	PHD	PHRF1 CHD3 KMT2C KMT2D KMT2A	9.53e-04	89	158	5	SM00249
Domain	Znf_PHD	PHRF1 CHD3 KMT2C KMT2D KMT2A	1.05e-03	91	158	5	IPR001965
Domain	ZF_PHD_2	PHRF1 CHD3 KMT2C KMT2D KMT2A	1.28e-03	95	158	5	PS50016
Domain	ZF_PHD_1	PHRF1 CHD3 KMT2C KMT2D KMT2A	1.34e-03	96	158	5	PS01359
Domain	HMG_box_dom	CHD3 KMT2C KMT2D SOX14	2.24e-03	65	158	4	IPR009071
Pathway	WP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY	MINK1 PRKAG3 PIK3R1 PIK3R2 PRKAB2 MAP3K9 IRS2 MAP4K4	1.38e-05	132	117	8	M39338
Pathway	REACTOME_PI3K_AKT_ACTIVATION	PIK3R1 PIK3R2 IRS2	3.03e-05	8	117	3	MM14776
Pathway	REACTOME_PI3K_AKT_ACTIVATION	PIK3R1 PIK3R2 IRS2	4.51e-05	9	117	3	M714
Pathway	REACTOME_SIGNALING_BY_PDGF	COL5A1 COL6A6 BCAR1 PIK3R1 PIK3R2	1.07e-04	57	117	5	MM14713
Pathway	REACTOME_SIGNALING_BY_PDGF	COL5A1 COL6A6 BCAR1 PIK3R1 PIK3R2	1.17e-04	58	117	5	M2049
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NDST1 GBF1 SZT2 BICRA AKNA NBL1 DGKQ SPIRE1 FAM110A NPHP4 ZDHHC8 HIRA MPRIP KMT2C SH3PXD2B INTS5 KMT2D DUSP16 ANKRD11 IRS2 HERC1 ZNF839 ANKRD33B CRAMP1 ELL RIC1	1.32e-11	1105	163	26	35748872
Pubmed	A human MAP kinase interactome.	SYNPO2 SUPT20H KIF26B EXPH5 BICRA ITSN1 HNRNPM DAB2 PAK6 KMT2C CSN2 PIK3R1 PIK3R2 DUSP16 MACF1 ZNF839 MAP4K4	1.65e-10	486	163	17	20936779
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	SYNPO2 GBF1 AFF2 BICRA ITSN1 APC2 HNRNPM DAB2 BCAR1 ZRANB3 MTA1 PIK3R1 PIK3R2 BSN FHIP1A RIC1	2.39e-10	430	163	16	35044719
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	GBF1 NELFA ITSN1 MINK1 RALGAPB PHRF1 DAB2 YTHDC2 CHD3 RREB1 CHAMP1 GATAD2B INTS5 KMT2D MTA1 KMT2A IRS2 MAP4K4 HOMEZ	4.76e-09	774	163	19	15302935
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DLG5 GBF1 KIF26B EXPH5 MINK1 RALGAPB SPIRE1 BCAR1 PAK6 MPRIP SH3PXD2B MAST4 SH3PXD2A ANKRD11 MAP3K9 KMT2A MACF1 IRS2 MAP4K4	2.61e-08	861	163	19	36931259
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DLG5 SZT2 PHRF1 AKNA SPIRE1 CHAMP1 KMT2C INTS5 MAST4 IGSF9 BSN MAP4K4 DAGLA CRAMP1 HOMEZ	3.38e-08	529	163	15	14621295
Pubmed	Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.	KMT2C KMT2D KMT2A	1.01e-07	3	163	3	23932714
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	SUPT20H COL6A6 EXPH5 DHX37 YTHDC2 KMT2C SNX14 ANKRD11 UBA6 KMT2A IRS2 HERC1 MAP4K4 RIC1	1.07e-07	497	163	14	36774506
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	COL5A1 DHRS3 BICRA MINK1 RALGAPB SPIRE1 CHD3 ZNF385A BCAR1 KMT2C CMIP SH3PXD2A MICAL2 NT5C2 ANKRD11 UBA6 MACF1 IGSF9 LRRC7 ANKRD12 ZNF839 DAGLA CRAMP1 RIC1	1.32e-07	1489	163	24	28611215
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	SUPT20H SZT2 NELFA BICRA RALGAPB NARS1 INO80D ABHD17C KMT2C SNX14 PACRGL ADO MOGS DBX1 PIK3R2 NPAP1 NT5C2 ANKRD11 KMT2A MAP4K4 CRAMP1 ELL	2.90e-07	1327	163	22	32694731
Pubmed	A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.	KMT2C KMT2D KMT2A	4.03e-07	4	163	3	23129768
Pubmed	The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.	KMT2C KMT2D KMT2A	4.03e-07	4	163	3	24081332
Pubmed	The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells.	ADAM19 ADAM12 SH3PXD2A	4.03e-07	4	163	3	12615925
Pubmed	N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.	SYNPO2 INO80D ZNF688 MPRIP KMT2C INTS5 ANKRD11 FYB1 CRAMP1	9.46e-07	217	163	9	34048709
Pubmed	Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells.	HIC1 CHD3 MTA1	2.00e-06	6	163	3	20547755
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	BOD1 KMT2C KMT2D KMT2A	3.18e-06	22	163	4	26886794
Pubmed	Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.	KMT2C KMT2D KMT2A	3.49e-06	7	163	3	36598580
Pubmed	Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.	BOD1 KMT2C KMT2D KMT2A FMNL1	3.80e-06	50	163	5	37974198
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	DLG5 EXPH5 ITSN1 HNRNPM YTHDC2 ZDHHC8 MACF1 LRRC7 MAP4K4	4.58e-06	263	163	9	34702444
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SUPT20H BICRA PHRF1 HNRNPM YTHDC2 CHD3 RREB1 CHAMP1 INO80D GATAD2B MTA1 PIK3R1 PIK3R2 MACF1 IRS2 TAF4B CDH16 SEZ6L	5.54e-06	1116	163	18	31753913
Pubmed	Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B.	PIK3R1 PIK3R2 IRS2	5.56e-06	8	163	3	12167717
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2C KMT2D KMT2A	5.56e-06	8	163	3	23130995
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	KMT2C KMT2D KMT2A	5.56e-06	8	163	3	22266653
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	AFF2 SZT2 EXPH5 YTHDC2 MPRIP KMT2C KMT2A BSN	6.72e-06	208	163	8	33230847
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	DLG5 SUPT20H MINK1 RALGAPB PHRF1 SPIRE1 YTHDC2 FAM110A ZNF385A INO80D GATAD2B HIRA MPRIP KMT2C INTS5 MTA1 ANKRD11 KMT2A MACF1 CLP1 FHIP1A	7.56e-06	1497	163	21	31527615
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2C KMT2D KMT2A	8.32e-06	9	163	3	22665483
Pubmed	DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.	PLEKHG4 CHD3 ABHD17C HIRA PACRGL MICAL2 DUSP16 PRKAB2 SOX14 FMNL1	9.31e-06	364	163	10	31391242
Pubmed	P110delta, a novel phosphoinositide 3-kinase in leukocytes.	PIK3R1 PIK3R2 IRS2	1.18e-05	10	163	3	9113989
Pubmed	SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.	PIK3R1 PIK3R2 IRS2	1.62e-05	11	163	3	12052866
Pubmed	Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase.	PIK3R1 PIK3R2 IRS2	2.16e-05	12	163	3	9624169
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	KMT2C KMT2D KMT2A	2.16e-05	12	163	3	27563068
Pubmed	NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment.	CHD3 GATAD2B MTA1	2.16e-05	12	163	3	22560079
Pubmed	Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.	KMT2C KMT2D	2.18e-05	2	163	2	28483418
Pubmed	Anthrax lethal factor cleaves regulatory subunits of phosphoinositide-3 kinase to contribute to toxin lethality.	PIK3R1 PIK3R2	2.18e-05	2	163	2	32895527
Pubmed	Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy.	PIK3R1 PIK3R2	2.18e-05	2	163	2	16227599
Pubmed	Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta.	PIK3R1 PIK3R2	2.18e-05	2	163	2	16679292
Pubmed	Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia.	PIK3R1 PIK3R2	2.18e-05	2	163	2	16679293
Pubmed	FMNL1 mediates nasopharyngeal carcinoma cell aggressiveness by epigenetically upregulating MTA1.	MTA1 FMNL1	2.18e-05	2	163	2	30013189
Pubmed	Molecular mechanism behind rotavirus NSP1-mediated PI3 kinase activation: interaction between NSP1 and the p85 subunit of PI3 kinase.	PIK3R1 PIK3R2	2.18e-05	2	163	2	23221569
Pubmed	The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.	KMT2C KMT2D	2.18e-05	2	163	2	34156443
Pubmed	Amyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity.	ADAM12 SH3PXD2A	2.18e-05	2	163	2	15710903
Pubmed	Genetic reduction of class IA PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo.	PIK3R1 PIK3R2	2.18e-05	2	163	2	16239435
Pubmed	Acute inhibition of PI3K-PDK1-Akt pathway potentiates insulin secretion through upregulation of newcomer granule fusions in pancreatic β-cells.	PIK3R1 PIK3R2	2.18e-05	2	163	2	23077605
Pubmed	Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms.	PIK3R1 PIK3R2	2.18e-05	2	163	2	21109194
Pubmed	Identification of insulin receptor substrate 1 (IRS-1) and IRS-2 as signaling intermediates in the alpha6beta4 integrin-dependent activation of phosphoinositide 3-OH kinase and promotion of invasion.	PIK3R1 IRS2	2.18e-05	2	163	2	11438664
Pubmed	Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy.	PIK3R1 IRS2	2.18e-05	2	163	2	23617393
Pubmed	KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.	KMT2C KMT2D	2.18e-05	2	163	2	31924266
Pubmed	Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors.	PIK3R1 PIK3R2	2.18e-05	2	163	2	35395865
Pubmed	Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.	KMT2C KMT2D	2.18e-05	2	163	2	27280393
Pubmed	T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling.	PIK3R1 PIK3R2	2.18e-05	2	163	2	17164340
Pubmed	Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion.	IRS2 MAP4K4	2.18e-05	2	163	2	19690174
Pubmed	Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.	KMT2C KMT2D	2.18e-05	2	163	2	36869380
Pubmed	Set1 and MLL1/2 Target Distinct Sets of Functionally Different Genomic Loci In Vivo.	KMT2D KMT2A	2.18e-05	2	163	2	26711341
Pubmed	The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma.	SH3PXD2B SH3PXD2A	2.18e-05	2	163	2	27802184
Pubmed	Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.	KMT2C KMT2D	2.18e-05	2	163	2	28967912
Pubmed	Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity.	PIK3R1 PIK3R2	2.18e-05	2	163	2	18534979
Pubmed	Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase.	PIK3R1 PIK3R2	2.18e-05	2	163	2	17071741
Pubmed	Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant.	KMT2D KMT2A	2.18e-05	2	163	2	24423662
Pubmed	Association of p130CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entry.	BCAR1 PIK3R1	2.18e-05	2	163	2	10799562
Pubmed	Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease.	ADAM12 SH3PXD2A	2.18e-05	2	163	2	17440933
Pubmed	Intracellular movement of green fluorescent protein-tagged phosphatidylinositol 3-kinase in response to growth factor receptor signaling.	PIK3R1 PIK3R2	2.18e-05	2	163	2	10459020
Pubmed	Lipid-binding hSH3 domains in immune cell adapter proteins.	PRAM1 FYB1	2.18e-05	2	163	2	16831444
Pubmed	Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement.	PIK3R1 PIK3R2	2.18e-05	2	163	2	15767666
Pubmed	Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.	KMT2C KMT2D	2.18e-05	2	163	2	25346535
Pubmed	HIC1 (hypermethylated in cancer 1) SUMOylation is dispensable for DNA repair but is essential for the apoptotic DNA damage response (DDR) to irreparable DNA double-strand breaks (DSBs).	HIC1 MTA1	2.18e-05	2	163	2	27935866
Pubmed	NDUFC2 deficiency exacerbates endothelial mesenchymal transformation during ischemia-reperfusion via NLRP3.	NDUFC2-KCTD14 NDUFC2	2.18e-05	2	163	2	37506315
Pubmed	A study of the association between the ADAM12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease.	ADAM12 SH3PXD2A	2.18e-05	2	163	2	19837132
Pubmed	Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.	KMT2C KMT2D	2.18e-05	2	163	2	36601880
Pubmed	Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta.	PIK3R1 PIK3R2	2.18e-05	2	163	2	1314371
Pubmed	Direct interaction between the cytoplasmic tail of ADAM 12 and the Src homology 3 domain of p85alpha activates phosphatidylinositol 3-kinase in C2C12 cells.	ADAM12 PIK3R1	2.18e-05	2	163	2	11313349
Pubmed	MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.	CHD3 GATAD2B MTA1	3.54e-05	14	163	3	16428440
Pubmed	NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination.	CHD3 GATAD2B MTA1	3.54e-05	14	163	3	25150861
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SUPT20H PHRF1 HNRNPM CHD3 RREB1 CHAMP1 INO80D GATAD2B HIRA KMT2C INTS5 KMT2D MTA1 MOGS ZIC5 ANKRD11 KMT2A HOMEZ	3.96e-05	1294	163	18	30804502
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	NELFA CHD3 CHAMP1 HIRA ARID3B KMT2D KMT2A CLP1	4.15e-05	268	163	8	33640491
Pubmed	Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program.	APC2 KMT2D KMT2A	4.41e-05	15	163	3	16510875
Pubmed	NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development.	CHD3 GATAD2B MTA1	4.41e-05	15	163	3	19927129
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	DHRS3 KIF26B ITSN1 HNRNPM NARS1 DGKA KMT2C ADO MOGS DUSP16 MAP3K9 LRRC7 ITPRIPL1	4.74e-05	736	163	13	29676528
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ITSN1 MINK1 APC2 HNRNPM GATAD2B HIRA MPRIP SH3PXD2B NT5C2 UBA6 MACF1 LRRC7 BSN MAP4K4 SEC23A	5.17e-05	963	163	15	28671696
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	POLD2 ITSN1 TUT7 DGKA SPIRE1 CHD3 ZRANB3 EZHIP KMT2C SH3PXD2B MTA1 PIK3R1 MAP3K9 MACF1 ANKRD12 HERC1	5.45e-05	1084	163	16	11544199
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DHX37 TUT7 MINK1 RALGAPB DGKA YTHDC2 CHD3 POLR3A MOGS KMT2A MAP4K4 RIC1	6.15e-05	650	163	12	38777146
Pubmed	A metalloprotease-disintegrin participating in myoblast fusion.	ADAM19 ADAM12	6.53e-05	3	163	2	7566181
Pubmed	Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase.	PIK3R1 PIK3R2	6.53e-05	3	163	2	16006513
Pubmed	Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway.	PIK3R1 PIK3R2	6.53e-05	3	163	2	10627473
Pubmed	Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells.	PIK3R2 IRS2	6.53e-05	3	163	2	9651378
Pubmed	Purification and characterization of truncated human AMPK alpha 2 beta 2 gamma 3 heterotrimer from baculovirus-infected insect cells.	PRKAG3 PRKAB2	6.53e-05	3	163	2	19836452
Pubmed	Growth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling.	PIK3R1 IRS2	6.53e-05	3	163	2	8910607
Pubmed	Class 1A PI3K regulates vessel integrity during development and tumorigenesis.	PIK3R1 PIK3R2	6.53e-05	3	163	2	18621722
Pubmed	Spatially- and temporally-restricted expression of meltrin alpha (ADAM12) and beta (ADAM19) in mouse embryo.	ADAM19 ADAM12	6.53e-05	3	163	2	9622634
Pubmed	Genetic disruption of the sh3pxd2a gene reveals an essential role in mouse development and the existence of a novel isoform of tks5.	SH3PXD2B SH3PXD2A	6.53e-05	3	163	2	25259869
Pubmed	Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes.	PIK3R1 PIK3R2	6.53e-05	3	163	2	12730242
Pubmed	Exploring new genetic variants within COL5A1 intron 4-exon 5 region and TGF-β family with risk of anterior cruciate ligament ruptures.	COL5A1 TGFBR3	6.53e-05	3	163	2	31922278
Pubmed	Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment.	KMT2D KMT2A	6.53e-05	3	163	2	26902498
Pubmed	Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice.	KMT2A ELL	6.53e-05	3	163	2	10995463
Pubmed	Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation.	SH3PXD2B SH3PXD2A	6.53e-05	3	163	2	20609497
Pubmed	The p85beta regulatory subunit of phosphoinositide 3-kinase has unique and redundant functions in B cells.	PIK3R1 PIK3R2	6.53e-05	3	163	2	19811262
Pubmed	Mammalian diacylglycerol kinases, a family of lipid kinases with signaling functions.	DGKA DGKQ	6.53e-05	3	163	2	10206945
Pubmed	T cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinase.	PIK3R1 PIK3R2	6.53e-05	3	163	2	18453570
Pubmed	High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.	PIK3R1 PIK3R2	6.53e-05	3	163	2	21984976
Pubmed	Physical and functional association of c-Src and adhesion and degranulation promoting adaptor protein (ADAP) in osteoclastogenesis in vitro.	BCAR1 FYB1	6.53e-05	3	163	2	16020549
Pubmed	Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat.	COX10 FMNL1	6.53e-05	3	163	2	9787083
Interaction	TOP3B interactions	NDST1 GBF1 SZT2 BICRA HNRNPM AKNA NBL1 DGKQ SPIRE1 FAM110A NPHP4 ZDHHC8 HIRA MPRIP KMT2C SH3PXD2B INTS5 KMT2D MOGS DUSP16 ANKRD11 IRS2 HERC1 ZNF839 ANKRD33B CRAMP1 ELL SEC23A RIC1	3.91e-06	1470	159	29	int:TOP3B
Interaction	CRX interactions	IGFN1 SZT2 BICRA RREB1 ZNF688 HIRA KMT2C KMT2D PRKAB2 SOX14 HOMEZ	5.74e-06	254	159	11	int:CRX
Interaction	YWHAZ interactions	DLG5 SYNPO2 GBF1 COL6A6 KIF26B NELFA EXPH5 MINK1 RALGAPB SPIRE1 BCAR1 PAK6 MPRIP ARID3B MAST4 SH3PXD2A PIK3R1 PIK3R2 DUSP16 MAP3K9 KMT2A MACF1 IRS2 PRR14L ZNF839 HOMEZ	1.36e-05	1319	159	26	int:YWHAZ
Interaction	SKAP1 interactions	EXPH5 NPHP4 POLR3A PRAM1 PIK3R2 PRR14L FYB1	1.64e-05	102	159	7	int:SKAP1
Interaction	FBXO22 interactions	SUPT20H COL6A6 EXPH5 DHX37 YTHDC2 BCAR1 KMT2C SNX14 ANKRD11 UBA6 KMT2A IRS2 HERC1 MAP4K4 RIC1	2.55e-05	540	159	15	int:FBXO22
Interaction	ASF1A interactions	NELFA BICRA RREB1 GATAD2B POLR3A HIRA KMT2D MTA1 KMT2A ELL	2.95e-05	249	159	10	int:ASF1A
Interaction	YWHAG interactions	DLG5 SYNPO2 GBF1 KIF26B EXPH5 MINK1 RALGAPB HNRNPM SPIRE1 BCAR1 PAK6 AFAP1L1 MPRIP MAST4 SH3PXD2A PIK3R1 DUSP16 ANKRD11 MAP3K9 KMT2A MACF1 IRS2 MAP4K4 HOMEZ	4.50e-05	1248	159	24	int:YWHAG
Interaction	YWHAB interactions	DLG5 GBF1 KIF26B NELFA EXPH5 MINK1 RALGAPB SPIRE1 BCAR1 PAK6 AFAP1L1 MPRIP MAST4 SH3PXD2A PIK3R2 DUSP16 MAP3K9 KMT2A MACF1 IRS2 HOMEZ	4.97e-05	1014	159	21	int:YWHAB
Interaction	YWHAE interactions	DLG5 GBF1 KIF26B EXPH5 MINK1 RALGAPB SPIRE1 FAM110A BCAR1 PAK6 AFAP1L1 MPRIP ARID3B MAST4 SH3PXD2A PIK3R1 PIK3R2 DUSP16 NT5C2 MAP3K9 KMT2A MACF1 IRS2 ZNF839	4.98e-05	1256	159	24	int:YWHAE
Interaction	TRIM54 interactions	CHD3 FAM110A RUNX1T1 ABHD17C CMIP MICAL2 DUSP16 PRKAB2 ANKRD11 SOX14 FMNL1	5.03e-05	321	159	11	int:TRIM54
Interaction	YWHAH interactions	DLG5 GBF1 KIF26B EXPH5 MINK1 RALGAPB SPIRE1 BCAR1 PAK6 MPRIP SH3PXD2B MAST4 SH3PXD2A DUSP16 ANKRD11 MAP3K9 KMT2A MACF1 IRS2 HERC1 MAP4K4 HOMEZ	5.59e-05	1102	159	22	int:YWHAH
Interaction	ITFG2 interactions	ADAM19 GBF1 SZT2 SH3PXD2B	8.71e-05	30	159	4	int:ITFG2
Interaction	RAC1 interactions	NDUFC2-KCTD14 DLG5 GBF1 PLEKHG4 KIF26B TMEM51 MINK1 RALGAPB DAB2 BCAR1 PAK6 ZDHHC8 NDUFC2 CMIP MOGS CSN2 PIK3R1 PIK3R2 MACF1 MAP4K4 FMNL1	9.71e-05	1063	159	21	int:RAC1
Cytoband	9q21.32	SPATA31D4 SPATA31D1 SPATA31D3	4.08e-05	19	163	3	9q21.32
Cytoband	2p23.1	XDH OTOF	3.46e-04	8	163	2	2p23.1
GeneFamily	Ferlin family	OTOF FER1L4 FER1L5	3.15e-06	6	99	3	828
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2C KMT2D KMT2A PRDM6	3.46e-05	34	99	4	487
GeneFamily	PHD finger proteins	PHRF1 CHD3 KMT2C KMT2D KMT2A	1.35e-04	90	99	5	88
GeneFamily	AF4/FMR2 family\|Super elongation complex	AFF2 ELL	1.04e-03	9	99	2	1280
GeneFamily	Ubiquitin like modifier activating enzymes	MOCS3 UBA6	1.30e-03	10	99	2	100
GeneFamily	EF-hand domain containing\|Diacylglycerol kinases	DGKA DGKQ	1.30e-03	10	99	2	1178
GeneFamily	PDZ domain containing	DLG5 SYNPO2 FRMPD4 MAST4 LRRC7	1.49e-03	152	99	5	1220
GeneFamily	PHD finger proteins\|NuRD complex	CHD3 MTA1	1.89e-03	12	99	2	1305
GeneFamily	Collagens	COL5A1 COL13A1 COL6A6	2.04e-03	46	99	3	490
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	GATAD2B MTA1	2.98e-03	15	99	2	82
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG4 ITSN1 AFAP1L1 MPRIP IRS2	5.51e-03	206	99	5	682
Coexpression	BROWNE_HCMV_INFECTION_4HR_DN	HIC1 SUPT20H POLD2 KATNB1 RUNX1T1 CHRNB1 MPRIP MOCS3 MICAL2 PRKAB2	3.84e-06	252	161	10	M789
Coexpression	GSE557_WT_VS_CIITA_KO_DC_DN	DLG5 HIC1 CACUL1 ARID3B KMT2D CMIP SH3PXD2A C3orf70 MAP3K9	4.30e-06	200	161	9	M6008
Coexpression	WIEDERSCHAIN_TARGETS_OF_BMI1_AND_PCGF2	COL5A1 ADAM19 CCDC80 RREB1 MICAL2	2.66e-05	57	161	5	M2316
Coexpression	MEL18_DN.V1_UP	ADAM19 COL13A1 TMEM51 RREB1 ADAM12 TGFBR3 KMT2A	2.75e-05	141	161	7	M2784
Coexpression	GSE41867_NAIVE_VS_DAY6_LCMV_EFFECTOR_CD8_TCELL_DN	SUPT20H CACUL1 SZT2 TUT7 AKNA INO80D KMT2D SH3PXD2A	3.46e-05	200	161	8	M9463
Coexpression	GSE45881_CXCR6HI_VS_CXCR1LO_COLONIC_LAMINA_PROPRIA_UP	MINK1 DGKA YTHDC2 MTA1 MAST4 MACF1 HERC1 FMNL1	3.46e-05	200	161	8	M9889
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	IGFN1 FRMPD4 AFF2 COL6A6 ATCAY APC2 CHD3 RUNX1T1 CMIP MAST4 SH3PXD2A PRKAB2 MAP3K9 LRRC7 SOX14 ANKRD12 HERC1 BSN SEZ6L	5.19e-05	1106	161	19	M39071
Coexpression	MULLIGHAN_MLL_SIGNATURE_2_DN	DHRS3 KATNB1 DAB2 NBL1 RUNX1T1 MAST4 KMT2A MACF1 CDH16	6.01e-05	279	161	9	M16867
Coexpression	PILON_KLF1_TARGETS_UP	KIF26B ITSN1 RALGAPB DAB2 BCAR1 ADAM12 TGFBR3 SNX14 NT5C2 KMT2A IRS2 RIC1	6.88e-05	503	161	12	M2226
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL5A1 COL13A1 COL6A6 KIF26B NBL1 RUNX1T1 FREM1 ABHD17C HECTD2 PRDM6	2.74e-09	194	163	10	35f132cc38ac133be01834ed0946188aa0757eb4
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL5A1 COL13A1 FRMPD4 COL6A6 KIF26B CCDC80 RUNX1T1 FREM1 LRRC7 PRDM6	2.74e-09	194	163	10	89b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	COL5A1 COL13A1 COL6A6 HIF3A RUNX1T1 FREM1 MAST4 HECTD2 MACF1 PRDM6	3.02e-09	196	163	10	1450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCell	Bronchial-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL5A1 SYNPO2 COL6A6 CCDC80 HIF3A RUNX1T1 FREM1 TGFBR3 SH3PXD2B PRDM6	3.67e-09	200	163	10	389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 SYNPO2 IGFN1 CCDC80 HIF3A RUNX1T1 SH3PXD2B MICAL2 PIK3R1	3.78e-08	191	163	9	2c51850f5c559d665b8a27a12b75af9ed58dffe1
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL5A1 COL13A1 COL6A6 NBL1 HIF3A RUNX1T1 FREM1 MACF1 PRDM6	3.78e-08	191	163	9	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL5A1 COL13A1 COL6A6 NBL1 HIF3A RUNX1T1 FREM1 MACF1 PRDM6	3.95e-08	192	163	9	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 SYNPO2 IGFN1 CCDC80 HIF3A RUNX1T1 SH3PXD2B MICAL2 PIK3R1	4.13e-08	193	163	9	09a9ab029f01234459a88e3e994fe90ef4cbb8c6
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 SYNPO2 IGFN1 DHRS3 CCDC80 HIF3A RUNX1T1 MICAL2 PTCH2	4.32e-08	194	163	9	c49f72441b3557e2c3a9c4239e68c0cf0652814b
ToppCell	COVID_non-vent-Lymphocytic-T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	DGKA CHD3 MPRIP MAST4 PIK3R1 DUSP16 KMT2A MACF1 ANKRD12	4.51e-08	195	163	9	4bdedd924564a260841a9153604026b57487c83d
ToppCell	IPF-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	COL5A1 COL6A6 KIF26B RUNX1T1 ADAM12 SH3PXD2B SH3PXD2A MACF1 PRDM6	4.93e-08	197	163	9	f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCell	COVID-19-lung-Fibroblast\|COVID-19 / Disease (COVID-19 only), tissue and cell type	COL5A1 COL6A6 KIF26B NBL1 CCDC80 RUNX1T1 ADAM12 SH3PXD2B PRDM6	5.14e-08	198	163	9	3ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	COL5A1 COL13A1 COL6A6 HIF3A RUNX1T1 FREM1 MAST4 MACF1 PRDM6	5.14e-08	198	163	9	17dc055e2a289496d9c5cdbf3297bdf906dc6d22
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL5A1 COL6A6 CCDC80 HIF3A RUNX1T1 FREM1 TGFBR3 SH3PXD2B PRDM6	5.61e-08	200	163	9	cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AFF2 COL6A6 MAST4 SH3PXD2A HERC1 BSN ANKRD33B SEZ6L	3.16e-07	178	163	8	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	COL13A1 NBL1 CCDC80 RUNX1T1 TGFBR3 LRRC7 SLITRK6 PRDM6	4.23e-07	185	163	8	1ac6a32cc56d5d819649bdd99518e2ead0eead4c
ToppCell	Control-Fibroblasts-Adventitial_FB\|Control / group, cell type (main and fine annotations)	COL5A1 SYNPO2 NBL1 CCDC80 RUNX1T1 FREM1 TGFBR3 SH3PXD2B	4.78e-07	188	163	8	706a26c372add839d947749f0521a0e1f5c9b0ec
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL5A1 COL13A1 COL6A6 KIF26B CCDC80 RUNX1T1 FREM1 PRDM6	4.98e-07	189	163	8	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	COL5A1 SYNPO2 COL6A6 NBL1 CCDC80 RUNX1T1 FREM1 PRDM6	5.18e-07	190	163	8	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	COL13A1 XDH HIF3A RREB1 FREM1 PIK3R1 MACF1 PRDM6	5.39e-07	191	163	8	e7c605b56934d1383237c1f946dbccef25d91368
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL5A1 COL13A1 COL6A6 KIF26B CCDC80 RUNX1T1 FREM1 PRDM6	5.61e-07	192	163	8	deeecd26972241846b4cb998edf0c7a87ff0c4df
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	COL13A1 NBL1 HIF3A RUNX1T1 MAST4 PIK3R1 MACF1 SLITRK6	5.84e-07	193	163	8	9f69edc97b868d23998abc98928a2e89a885ef8a
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL5A1 COL13A1 HIF3A RUNX1T1 FREM1 PIK3R1 MACF1 PRDM6	5.84e-07	193	163	8	99525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D231\|Adult / Lineage, Cell type, age group and donor	COL5A1 COL13A1 COL6A6 KIF26B NBL1 RUNX1T1 FREM1 PRDM6	5.84e-07	193	163	8	ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL5A1 COL13A1 FRMPD4 COL6A6 CCDC80 RUNX1T1 FREM1 PRDM6	5.84e-07	193	163	8	fb28717fadd06c3840636d25409ce80c9254bd34
ToppCell	Mesenchymal-matrix_fibroblast_1_cell\|World / Lineage, Cell type, age group and donor	COL5A1 COL13A1 COL6A6 NBL1 HIF3A RUNX1T1 FREM1 PRDM6	5.84e-07	193	163	8	acad568621ed677031797b8c2e34dafea798d681
ToppCell	Control-Fibroblasts-Intermediate_pathological_FB\|Control / group, cell type (main and fine annotations)	COL5A1 COL6A6 KIF26B NBL1 CCDC80 RUNX1T1 SH3PXD2B PRDM6	6.07e-07	194	163	8	03a269f75a481ea54aea8e6444605db8d6df493d
ToppCell	PND01-03-samps-Mesenchymal\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	COL5A1 COL13A1 RUNX1T1 FREM1 TGFBR3 PIK3R1 MACF1 PRDM6	6.07e-07	194	163	8	4f9bd0ded0dde1df885850714f29e73e992539a5
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	COL13A1 COL6A6 HIF3A RUNX1T1 MAST4 PIK3R1 MACF1 SLITRK6	6.07e-07	194	163	8	71d3c7448b1734de54187f902f65649f9283bd4c
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL5A1 COL13A1 FRMPD4 COL6A6 CCDC80 RUNX1T1 FREM1 PRDM6	6.07e-07	194	163	8	60622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCell	LPS-antiTNF-Stromal_mesenchymal\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL5A1 SYNPO2 COL13A1 COL6A6 CCDC80 RUNX1T1 FREM1 PRDM6	6.07e-07	194	163	8	6e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 SYNPO2 IGFN1 DHRS3 CCDC80 RUNX1T1 MICAL2 PTCH2	6.31e-07	195	163	8	3c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 SYNPO2 ADAM19 HIF3A RUNX1T1 MICAL2 LRRC7 PRDM6	6.56e-07	196	163	8	1522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCell	Children_(3_yrs)-Mesenchymal\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL5A1 COL6A6 HIF3A RUNX1T1 FREM1 TGFBR3 PIK3R1 PRDM6	6.56e-07	196	163	8	bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 SYNPO2 ADAM19 HIF3A RUNX1T1 MICAL2 LRRC7 PRDM6	6.56e-07	196	163	8	1c8294014713684b50885e638668f2ce75f357f0
ToppCell	COVID_non-vent-Lymphocytic\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	DGKA CHD3 MPRIP TGFBR3 IGHM KMT2A MACF1 ANKRD12	6.81e-07	197	163	8	c672915f8c8c1e948d251f6eaf9f84a5600c1193
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DGKA CHD3 KMT2C ANKRD11 KMT2A MACF1 ANKRD12 HERC1	6.81e-07	197	163	8	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	Adult-Mesenchymal\|Adult / Lineage, Cell type, age group and donor	COL5A1 COL6A6 CCDC80 HIF3A RUNX1T1 FREM1 TGFBR3 PRDM6	7.08e-07	198	163	8	26e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCell	COVID-19-lung-Fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	COL5A1 COL6A6 KIF26B NBL1 CCDC80 RUNX1T1 ADAM12 PRDM6	7.08e-07	198	163	8	df3de77216f5c5d6141ec44d01c56b942f611838
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SYNPO2 CYP4Z1 HIF3A RUNX1T1 AFAP1L1 PTCH2 LRRC7 ANKRD33B	7.35e-07	199	163	8	9c2db0bb94cba71a3cc1827844da090e213e0258
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	COL5A1 COL13A1 COL6A6 CCDC80 FREM1 TGFBR3 MACF1 SLITRK6	7.35e-07	199	163	8	30d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCell	10x3'2.3-week_17-19-Mesenchymal_fibro-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	COL5A1 COL6A6 PLEKHG4 NBL1 CCDC80 RUNX1T1 TGFBR3 SLITRK6	7.64e-07	200	163	8	747c61d4e0b746278ae1f45ca4cd556c6961c76a
ToppCell	18-Airway-Mesenchymal-Mesenchyme_SERPINF1-high\|Airway / Age, Tissue, Lineage and Cell class	COL5A1 HIC1 COL6A6 DAB2 NBL1 CCDC80 RUNX1T1 PRDM6	7.64e-07	200	163	8	14ae55660f7412518dcb5cb982f6fe9f23553cfb
ToppCell	10x3'2.3-week_17-19-Mesenchymal_fibro\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	COL5A1 COL6A6 PLEKHG4 NBL1 CCDC80 RUNX1T1 TGFBR3 SLITRK6	7.64e-07	200	163	8	de1d193f773f4e2927baa6fc38d29754b015c6e6
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL5A1 COL13A1 COL6A6 HIF3A RUNX1T1 FREM1 SH3PXD2B PRDM6	7.64e-07	200	163	8	34f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL5A1 CCDC80 HIF3A RUNX1T1 FREM1 TGFBR3 ANKRD33B PRDM6	7.64e-07	200	163	8	0c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCell	primary_visual_cortex\|World / Per Region, Lineage, Cell class, Cell type, Cell subtype	COL5A1 IGFN1 KMT2A ANKRD33B FHIP1A FMNL1 SEZ6L	9.05e-07	141	163	7	605d7b28e99c943f64b4095855a6f9f70e92cb09
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SYNPO2 DIP2C-AS1 HIF3A TGFBR3 PIK3R1 C3orf70 PRDM6	1.57e-06	153	163	7	1524557514668f515ac1bbe847611f564b265b42
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 CYP4Z1 CCDC80 SH3PXD2B MICAL2 LRRC7 PRDM6	2.92e-06	168	163	7	4b2d29a7843bf45922038c093ca7ec0600756adc
ToppCell	ILEUM-non-inflamed-(3)_MNP-(3)_mature_DC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SYNPO2 PLEKHG4 CHD3 ABHD17C MAP4K4 ANKRD33B PRDM6	3.28e-06	171	163	7	341f9f79c1ed654ab347e25dc4936f89ffdf9617
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNPO2 CYP4Z1 CCDC80 SH3PXD2B MICAL2 LRRC7 PRDM6	3.28e-06	171	163	7	5d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AFF2 MAST4 SH3PXD2A HERC1 BSN ANKRD33B SEZ6L	3.68e-06	174	163	7	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Mesenchymal_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SYNPO2 FRMPD4 KIF26B RUNX1T1 TGFBR3 PTCH2 SLITRK6	4.77e-06	181	163	7	9b2d207dc9fc2228a1555ed360286bb7c2d988ff
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	SYNPO2 ADAM19 KIF26B NBL1 PTCH2 LRRC7 PRDM6	5.12e-06	183	163	7	e84539978ab4de42e19186aed00f24bb50cbc21f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 SYNPO2 IGFN1 CCDC80 RUNX1T1 MICAL2 LRRC7	5.31e-06	184	163	7	e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	COL13A1 NBL1 CCDC80 HIF3A RUNX1T1 SLITRK6 PRDM6	5.50e-06	185	163	7	9f19f04fc4d97dfc2dd78cde77b515f1cb5d51ec
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL5A1 SYNPO2 ADAM19 KIF26B TGFBR3 MICAL2 PRDM6	5.50e-06	185	163	7	e58a009aaf342be019a909747b1895d5987d4daf
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	COL13A1 NBL1 CCDC80 RUNX1T1 TGFBR3 SLITRK6 PRDM6	5.70e-06	186	163	7	7def03dd856b765bd3f493288641981c4f7fd26e
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	COL5A1 COL13A1 CCDC80 RUNX1T1 FREM1 SLITRK6 PRDM6	5.90e-06	187	163	7	a9316e2818217ec5feae9cf8816f7249803caee6
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	COL13A1 NBL1 CCDC80 HIF3A RUNX1T1 SLITRK6 PRDM6	5.90e-06	187	163	7	13731298bc562ec29582f5da1b4c97261284f6f1
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	INO80D KMT2C ANKRD11 KMT2A MACF1 ANKRD12 HERC1	6.11e-06	188	163	7	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 SYNPO2 DHRS3 CCDC80 HIF3A RUNX1T1 PIK3R1	6.11e-06	188	163	7	ce85a56ac27a6432421dde93a1bafa8b943244b9
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SYNPO2 ADAM19 KIF26B NBL1 PTCH2 LRRC7 PRDM6	6.11e-06	188	163	7	3004e961d214919e08c7cd5f10c3de5cf85b35a3
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL13A1 FRMPD4 COL6A6 CCDC80 RUNX1T1 FREM1 PRDM6	6.33e-06	189	163	7	a153b83314cf52808f685296cff8c95af3f4983d
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL13A1 NBL1 HIF3A RUNX1T1 FREM1 HECTD2 PRDM6	6.33e-06	189	163	7	203c80030df08ae112f9ae4043709f455d87ce89
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SYNPO2 ADAM19 KIF26B NBL1 PTCH2 LRRC7 PRDM6	6.33e-06	189	163	7	f75cebd4c3e54e297557449ba67ccc8d1a2a14f5
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 SYNPO2 ADAM19 MICAL2 C3orf70 LRRC7 PRDM6	6.55e-06	190	163	7	2e88e366d377d74deb53a4ea870973ce5c6532e8
ToppCell	PND07-28-samps-Mesenchymal-Matrix_fibroblast-FB-3\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	COL13A1 CCDC80 RUNX1T1 FREM1 MACF1 SLITRK6 PRDM6	6.55e-06	190	163	7	1196b8ea2c44c7c80f5ee589dd517e6a413f2077
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	COL5A1 COL13A1 CCDC80 HIF3A RUNX1T1 TGFBR3 SLITRK6	6.55e-06	190	163	7	7986586b7c82e91c71102cc8c4d7a689ae63ab4d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 SYNPO2 ADAM19 MICAL2 C3orf70 LRRC7 PRDM6	6.55e-06	190	163	7	562ee3b025c29edf07b8b344323edb49d82f1c7e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 SYNPO2 ADAM19 MICAL2 C3orf70 LRRC7 PRDM6	6.55e-06	190	163	7	0028f886c789ba238c031eae5d96acaed4af8c25
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAM19 MPRIP SH3PXD2A IGHM ANKRD11 MACF1 MAP4K4	6.55e-06	190	163	7	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 SYNPO2 ADAM19 MICAL2 C3orf70 LRRC7 PRDM6	6.55e-06	190	163	7	f5fb989afabb49d64d91324570cd8c80a4b9e67d
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL13A1 FRMPD4 COL6A6 CCDC80 RUNX1T1 FREM1 PRDM6	6.78e-06	191	163	7	b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL13A1 FRMPD4 COL6A6 CCDC80 RUNX1T1 FREM1 PRDM6	7.02e-06	192	163	7	6f4ef24dab544681304b7f8a9dc073e7edaa4cf5
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL13A1 FRMPD4 COL6A6 CCDC80 RUNX1T1 FREM1 PRDM6	7.02e-06	192	163	7	dcd924d6eb67d33ee9f5d3e8ab6e1d4283d6b708
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL5A1 COL13A1 COL6A6 CCDC80 RUNX1T1 FREM1 PRDM6	7.02e-06	192	163	7	3d0cb19f037f604253d7d728689aeaa94251e92b
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL5A1 COL6A6 NBL1 CCDC80 RUNX1T1 FREM1 PRDM6	7.02e-06	192	163	7	e0f4e4470a71bfa81d9dcd8594e5f82aafc24f81
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL5A1 COL6A6 NBL1 CCDC80 RUNX1T1 FREM1 PRDM6	7.26e-06	193	163	7	9ab47b360bee1d4f1092c2269e58acebe9584021
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL5A1 COL13A1 NBL1 RUNX1T1 FREM1 HECTD2 PRDM6	7.51e-06	194	163	7	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL5A1 COL6A6 CCDC80 RUNX1T1 PTCH2 LRRC7 PRDM6	7.51e-06	194	163	7	439d3f17c1f4736122b330e98add9292c7036a8e
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	COL5A1 COL13A1 COL6A6 CCDC80 HIF3A RUNX1T1 SLITRK6	7.51e-06	194	163	7	8c37bedb23285735ff3828db3889897fada8c95d
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	COL5A1 COL13A1 RUNX1T1 FREM1 MAST4 MACF1 PRDM6	7.76e-06	195	163	7	1cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell\|Adult / Lineage, Cell type, age group and donor	COL5A1 COL13A1 COL6A6 HIF3A RUNX1T1 FREM1 PRDM6	7.76e-06	195	163	7	61c9e09fc84d1012e472185d70ad0a06cee30d6e
ToppCell	COVID-19-Fibroblasts-Alveolar_FB\|COVID-19 / group, cell type (main and fine annotations)	COL5A1 COL13A1 COL6A6 KIF26B HIF3A RUNX1T1 PRDM6	7.76e-06	195	163	7	603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A6 KMT2C ANKRD11 KMT2A MACF1 HERC1 SEZ6L	7.76e-06	195	163	7	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	COVID_non-vent-Lymphocytic-T_cell-CD4+_Memory_T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	DGKA CHD3 MPRIP MAST4 DUSP16 KMT2A ANKRD12	7.76e-06	195	163	7	22191d361af136942508f1553ff41a626ed982ad
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A6 KMT2C ANKRD11 KMT2A MACF1 HERC1 SEZ6L	7.76e-06	195	163	7	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	PCW_05-06-Mesenchymal\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	COL5A1 COL13A1 CCDC80 HIF3A RUNX1T1 FREM1 PRDM6	8.03e-06	196	163	7	dca52c57ba35d9395cdbca8b881f12ece721b10f
ToppCell	PCW_07-8.5-Mesenchymal\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	COL5A1 COL13A1 CCDC80 RUNX1T1 FREM1 SLITRK6 PRDM6	8.03e-06	196	163	7	8e10802f52e5e1853ea4ad34bf9a32a34e6112b5
ToppCell	15-Distal-Mesenchymal\|Distal / Age, Tissue, Lineage and Cell class	COL5A1 COL13A1 NBL1 CCDC80 RUNX1T1 SLITRK6 PRDM6	8.03e-06	196	163	7	b8d95b5f4780e73d16dcc528e70a5496f0314373
ToppCell	nucseq-Mesenchymal-Fibroblastic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL5A1 COL6A6 CCDC80 HIF3A RUNX1T1 MACF1 PRDM6	8.03e-06	196	163	7	7d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL5A1 SYNPO2 COL6A6 RUNX1T1 TGFBR3 ANKRD33B PRDM6	8.30e-06	197	163	7	0dd71e399f253787fa546a7e90c5373180b89ffd
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	COL5A1 KIF26B NBL1 CCDC80 RUNX1T1 ADAM12 PRDM6	8.30e-06	197	163	7	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	PND01-Mesenchymal\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL5A1 COL13A1 CCDC80 TGFBR3 PIK3R1 MACF1 PRDM6	8.30e-06	197	163	7	292b8cc3dafddf5d323fe4e3d3ea5ac61e6ce027
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	COL6A6 RUNX1T1 FREM1 MAST4 HECTD2 MACF1 PRDM6	8.30e-06	197	163	7	0034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	COL5A1 KIF26B NBL1 CCDC80 RUNX1T1 ADAM12 PRDM6	8.30e-06	197	163	7	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	COL6A6 RUNX1T1 FREM1 MAST4 HECTD2 MACF1 PRDM6	8.30e-06	197	163	7	11a4c417f035e554431a8f03be13b5eefa3530c0
ToppCell	Control-Control-Lymphocyte-T/NK-NK_activated\|Control / Disease, condition lineage and cell class	DLG5 COL13A1 AKNA TGFBR3 FCRLB MACF1 HERC1	8.57e-06	198	163	7	76d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCell	T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	AKNA DGKA CHD3 TGFBR3 KMT2A MACF1 FYB1	8.57e-06	198	163	7	1ca6cd8e75891fdfaddbb4a7342eec9ca4d11e5d
Computational	Neighborhood of BMPR2	DLG5 RALGAPB SPIRE1 ADO MACF1 MAP4K4	7.97e-05	85	91	6	GCM_BMPR2
Drug	ammonium citrate	NARS1 NBL1 CSN2 CRAMP1 ELL	1.24e-07	18	159	5	CID000018171
Disease	limb-girdle muscular dystrophy (implicated_via_orthology)	OTOF FER1L4 FER1L5	5.00e-06	7	156	3	DOID:11724 (implicated_via_orthology)
Disease	Kleefstra syndrome 2 (implicated_via_orthology)	KMT2C KMT2D	2.78e-05	2	156	2	DOID:0080598 (implicated_via_orthology)
Disease	intellectual disability (implicated_via_orthology)	NDST1 ITSN1 GATAD2B BOD1 IRS2	4.96e-05	75	156	5	DOID:1059 (implicated_via_orthology)
Disease	Eye Abnormalities	NDST1 FREM1 SH3PXD2B	9.33e-05	17	156	3	C0015393
Disease	cortical surface area measurement	OMA1 KIF26B TUT7 NBL1 RUNX1T1 RREB1 RETSAT ADAM12 GATAD2B AFAP1L1 MPRIP MAST4 PIK3R1 NT5C2 MACF1 IGSF9 MAP4K4 PRDM6	2.81e-04	1345	156	18	EFO_0010736
Disease	Sezary Syndrome	CHD3 KMT2C KMT2D	3.86e-04	27	156	3	C0036920
Disease	glucagon measurement, glucose tolerance test	MACF1 HERC1	4.11e-04	6	156	2	EFO_0004307, EFO_0008463
Disease	congenital heart disease (implicated_via_orthology)	USP17L10 KMT2C KMT2D KMT2A	4.97e-04	69	156	4	DOID:1682 (implicated_via_orthology)
Disease	Intellectual Disability	NDST1 FRMPD4 APC2 CHD3 CHAMP1 KMT2C SNX14 NT5C2 MACF1	6.51e-04	447	156	9	C3714756
Disease	disease recurrence, unipolar depression, bipolar disorder, schizophrenia, sex interaction measurement	ATCAY PAK6 ADAM12	7.04e-04	33	156	3	EFO_0003761, EFO_0004952, EFO_0008343, MONDO_0004985, MONDO_0005090
Disease	brain measurement, neuroimaging measurement	OMA1 KIF26B NBL1 RUNX1T1 RREB1 GATAD2B MAST4 SH3PXD2A MACF1 IGSF9	7.22e-04	550	156	10	EFO_0004346, EFO_0004464
Disease	Agammaglobulinemia, non-Bruton type	PIK3R1 IGHM	7.62e-04	8	156	2	C1832241
Disease	cardiovascular disease	FREM1 IRX4 ABHD17C PRKAG3 CMIP ADO PIK3R1 NT5C2 PRDM6	7.62e-04	457	156	9	EFO_0000319
Disease	glomerular filtration rate, renal transplant outcome measurement	RUNX1T1 MICAL2 PIK3R1	8.38e-04	35	156	3	EFO_0005199, EFO_0005208
Disease	cortical thickness	OMA1 NBL1 RUNX1T1 RREB1 ADAM12 GATAD2B AFAP1L1 SH3PXD2B MAST4 SH3PXD2A PIK3R1 KMT2A MACF1 IGSF9 ELL	8.59e-04	1113	156	15	EFO_0004840
Disease	22q11 partial monosomy syndrome	RREB1 HIRA	9.76e-04	9	156	2	C3266101
Disease	level of Phosphatidylcholine (16:0_22:4) in blood serum	MAP4K4 DAGLA	9.76e-04	9	156	2	OBA_2045078
Disease	body weights and measures	CACUL1 PIK3R1 MAP3K9	1.07e-03	38	156	3	EFO_0004324
Disease	Asymmetric crying face association	RREB1 HIRA	1.22e-03	10	156	2	C0431406
Disease	22q11 Deletion Syndrome	RREB1 HIRA	1.22e-03	10	156	2	C2936346
Disease	hypertension	HIC1 SZT2 BCAR1 MPIG6B ABHD17C NT5C2 LRRC7	1.28e-03	307	156	7	EFO_0000537
Disease	prostate cancer (is_marker_for)	KMT2C KMT2D PIK3R1 PIK3R2 KMT2A	1.47e-03	156	156	5	DOID:10283 (is_marker_for)
Disease	coagulation factor XA measurement	AKNA FAM110A	1.48e-03	11	156	2	EFO_0020266
Disease	Childhood Medulloblastoma	HIC1 PTCH2 IRS2	1.53e-03	43	156	3	C0278510
Disease	Melanotic medulloblastoma	HIC1 PTCH2 IRS2	1.53e-03	43	156	3	C1275668
Disease	Medullomyoblastoma	HIC1 PTCH2 IRS2	1.53e-03	43	156	3	C0205833
Disease	Desmoplastic Medulloblastoma	HIC1 PTCH2 IRS2	1.53e-03	43	156	3	C0751291
Disease	Adult Medulloblastoma	HIC1 PTCH2 IRS2	1.53e-03	43	156	3	C0278876
Disease	Parkinson disease	GBF1 COL13A1 CYP4Z1 DGKQ CHRNB1 MAP4K4 ANKRD33B	1.65e-03	321	156	7	MONDO_0005180
Disease	neuroimaging measurement	OMA1 SZT2 KIF26B C2orf76 NBL1 PAK6 RUNX1T1 RREB1 GATAD2B AFAP1L1 MAST4 SH3PXD2A MACF1 IGSF9	1.67e-03	1069	156	14	EFO_0004346
Disease	Prostatic Neoplasms	COL5A1 ITSN1 CHD3 BCAR1 PAK6 KMT2C KMT2D PIK3R1 PIK3R2 KMT2A	1.69e-03	616	156	10	C0033578
Disease	Malignant neoplasm of prostate	COL5A1 ITSN1 CHD3 BCAR1 PAK6 KMT2C KMT2D PIK3R1 PIK3R2 KMT2A	1.69e-03	616	156	10	C0376358
Disease	congenital diaphragmatic hernia (implicated_via_orthology)	NDST1 FREM1	1.77e-03	12	156	2	DOID:3827 (implicated_via_orthology)
Disease	Agammaglobulinemia	PIK3R1 IGHM	1.77e-03	12	156	2	C0001768
Disease	apolipoprotein A 1 measurement	HNRNPM AKNA DGKQ SLC46A1 ZRANB3 PRKAG3 CMIP KMT2A MACF1 HERC1 ELL CDH16	1.90e-03	848	156	12	EFO_0004614
Disease	coagulation factor X measurement	AKNA FAM110A	2.08e-03	13	156	2	EFO_0020265
Disease	serum alanine aminotransferase measurement	DLG5 GBF1 EXPH5 PKD1L1 AKNA NARS1 XDH FRAT2 MPRIP PIK3R1 PIK3R2 ELL	2.32e-03	869	156	12	EFO_0004735
Disease	Medulloblastoma	HIC1 PTCH2 IRS2	2.37e-03	50	156	3	C0025149
Disease	cholesteryl esters to total lipids in IDL percentage	PRKAG3 CMIP MACF1	2.37e-03	50	156	3	EFO_0022247
Disease	Small cell carcinoma of lung	PAK6 RUNX1T1 KMT2A	2.95e-03	54	156	3	C0149925
Disease	brain aneurysm	MINK1 CCDC80 BCAR1 NT5C2	3.10e-03	113	156	4	EFO_0003870
Disease	DiGeorge Syndrome	RREB1 HIRA	3.17e-03	16	156	2	C0012236
Disease	Myasthenic Syndromes, Congenital, Slow Channel	COL13A1 CHRNB1	3.17e-03	16	156	2	C0751885
Disease	intracerebral hemorrhage	OMA1 FHIP1A	3.17e-03	16	156	2	EFO_0005669
Disease	CONOTRUNCAL ANOMALY FACE SYNDROME	RREB1 HIRA	3.17e-03	16	156	2	C0795907
Disease	Blood Platelet Disorders	MPIG6B FYB1	3.17e-03	16	156	2	C0005818
Disease	Shprintzen syndrome	RREB1 HIRA	3.17e-03	16	156	2	C0220704
Disease	cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	GBF1 DGKQ SLC46A1 PRKAG3 CMIP MACF1	3.58e-03	276	156	6	EFO_0004612, EFO_0020943
Disease	Congenital Myasthenic Syndromes, Postsynaptic	COL13A1 CHRNB1	3.59e-03	17	156	2	C0751883
Disease	urate measurement, spine bone mineral density	XDH PRDM6 RIC1	3.61e-03	58	156	3	EFO_0004531, EFO_0007701
Disease	atrial fibrillation	BICRA ABHD17C MPRIP SH3PXD2A HERC1 PRDM6 CRAMP1	3.70e-03	371	156	7	EFO_0000275
Disease	cholesterol to total lipids in IDL percentage	PRKAG3 CMIP MACF1	3.98e-03	60	156	3	EFO_0022233
Disease	Febrile seizure (within the age range of 3 months to 6 years)	HERC1 BSN	4.02e-03	18	156	2	HP_0002373
Disease	Congenital Myasthenic Syndromes, Presynaptic	COL13A1 CHRNB1	4.48e-03	19	156	2	C0751884
Disease	cholesterol to total lipids in medium VLDL percentage	PRKAG3 PRAM1 CMIP	4.56e-03	63	156	3	EFO_0022239
Disease	triglycerides:total lipids ratio, intermediate density lipoprotein measurement	MINK1 PRKAG3 CMIP MACF1	4.70e-03	127	156	4	EFO_0008595, EFO_0020947
Disease	C-reactive protein measurement	ADAM19 YTHDC2 HIF3A RREB1 GATAD2B CMIP MACF1 IRS2 TAF4B SLITRK6 BSN FYB1 MAP4K4 DAGLA	4.91e-03	1206	156	14	EFO_0004458
Disease	coagulation factor V measurement	PAK6 MAST4	4.96e-03	20	156	2	EFO_0008087
Disease	mean arterial pressure	COL5A1 SZT2 BCAR1 ABHD17C CMIP ADO NT5C2 PRDM6	5.21e-03	499	156	8	EFO_0006340

Protein segments in the cluster

Peptide	Gene	Start	Entry
DLKQILPFPLEPAPT	ZNF385A	26	Q96PM9
SFQPRPLRLPKPTDS	C2orf16	1446	Q68DN1
APALLSPPKIRFPIL	ARID3B	351	Q8IVW6
RSASPPQKRLQPPDF	ELL	316	P55199
PQKRLQPPDFIDPLA	ELL	321	P55199
QPPDFIDPLANKKPR	ELL	326	P55199
RFPESPKRFCPADPL	ANKRD11	1986	Q6UB99
IKPPNLFPLAPQEIT	NT5C2	531	P49902
PDQLLKEPPFPLSTR	HAAO	161	P46952
RPALCLSPQAPFPKL	PRKAG3	156	Q9UGI9
AKPFDPARTPLVLAA	BCAR1	336	P56945
DFSRPRPPQKALPAN	ADAM19	851	Q9H013
LNIAPRKATLQPLPP	ADO	66	Q96SZ5
EPSFFPEQKNRIIPP	AFF2	111	P51816
PSLASLLQPIPFPKE	CMIP	471	Q8IY22
QVRPKPEPVASPFLE	COX10	71	Q12887
KLPPDSCPLLVFVNP	DGKQ	581	P52824
FPKPNRFQPELSAPD	CHRNB1	401	P11230
FRSEERFKSPPILPP	PRKAB2	196	O43741
VPARPLPAKPALRQA	ADAM12	831	O43184
PPPSLSDPLKELFRQ	ANKRD12	1891	Q6UB98
LKFASVFQPPLPPDS	C3orf70	106	A6NLC5
FLKQDIPLRTNLPPP	C2orf76	41	Q3KRA6
LRKLAATAPALPQPP	CCDC80	331	Q76M96
PAAPAPRKASLLPLQ	ANKRD33B	396	A6NCL7
APTLFSKFIPNILPP	CACUL1	301	Q86Y37
REPIPDPLLPTVAKF	RIC1	876	Q4ADV7
LTAPLARAFPPAVPQ	IRX4	481	P78413
PNPLDLFKTSAPAPV	DAB2	481	P98082
PLFPEPPKTRISNLR	FAM47C	401	Q5HY64
ALFLIPRNPPPRLKS	MAP4K4	241	O95819
SPPEKPRARPAAAVL	SLC46A1	6	Q96NT5
FRPPQKDNPPSLVAK	PAK6	291	Q9NQU5
FPRKRDFTNEAPPAP	MPRIP	341	Q6WCQ1
TLGPKPFQLPFRPQD	KMT2C	3941	Q8NEZ4
APSPTLPAQFKQRAP	NELFA	361	Q9H3P2
PLRPFVIPFLKANLP	RUNX1T1	176	Q06455
IAPSFPQPLDSKPLL	LRRC7	726	Q96NW7
LPSLPPLPFQKLEEA	HIC1	286	Q14526
RPQPEFVLPRSEEKP	ATCAY	336	Q86WG3
SRGPEPPFFKQLIVP	ASAH2	626	Q9NR71
PPDFVPIVPALQKTR	KIF26B	886	Q2KJY2
AAPAQKPPGRRLFPE	EZHIP	156	Q86X51
RALPKGDFFPPERPQ	HNRNPM	281	P52272
AKLRFLAEEPQPPLP	FER1L4	646	A9Z1Z3
KINSEIPPLPFPSSR	HERC1	771	Q15751
ISLRLFPAKPEEFPP	HECTD2	291	Q5U5R9
PAPKAEPAIIPATRN	KATNB1	446	Q9BVA0
LFPVPADSRAPLQKP	BSN	3131	Q9UPA5
LAPQKPAPPLDTDRF	POLD2	181	P49005
PALLQSVPPKTFAFP	DBX1	126	A6NMT0
PVQPLLSKQPLFSPE	FAM110A	66	Q9BQ89
VPSLPPRNIKPPFDL	FYB1	416	O15117
PRNIKPPFDLKSPVN	FYB1	421	O15117
PINVLPKDDSPPFLI	FREM1	511	Q5H8C1
DKANLPVLPPVAVLP	DGKA	446	P23743
APSFRPKLAPVVIPA	DLG5	1116	Q8TDM6
RDFPLKPALPPASLA	PHRF1	1301	Q9P1Y6
RFLPDEARSLPPPKL	NDUFC2	11	O95298
PVAPSRLLPLKPVQA	NDST1	61	P52848
RLSPPFPLEPAQKSR	EXPH5	1751	Q8NEV8
KPPAPLLHFLPSAAN	GATAD2B	371	Q8WXI9
DNLKECLFVPLPPSP	NPIPB7	301	O75200
LAAPPPINKLALFPD	NBL1	16	P41271
QFAPPDIAPPLLIKL	PIK3R1	121	P27986
PSVCFLIPPPNKDAI	MACF1	916	Q9UPN3
PTKRPPSRIVFNEPL	NPHP4	81	O75161
EQKVDPALFPPVPLF	MOGS	421	Q13724
PLAAAAVAAEPLPPK	PRDM6	121	Q9NQX0
EQFSPPDVAPPLLVK	PIK3R2	116	O00459
PIAAPPKPEAARVAS	IRS2	1086	Q9Y4H2
PLTIPIPKTFRNAEP	ITPRIPL1	501	Q6GPH6
RFRPLSFEVPKPLFP	GMPPA	16	Q96IJ6
RKVAPPCLAQPAAPA	APC2	1816	O95996
RTKVAEAPPNLPLPV	FHIP1A	986	Q05DH4
IAELPPKVSVFVPPR	IGHM	106	P01871
AQLRPLPASPVPLKL	DBX2	71	Q6ZNG2
IDTEPRKPALFPEPA	CHAMP1	521	Q96JM3
PAADIQPPPIRRAKT	CHD3	246	Q12873
LAARPATDLPPKVVP	FRMPD4	971	Q14CM0
FLAAQKKAAVPAPPP	BOD1	156	Q96IK1
PKPDFIPESHFLRVP	DUSP16	196	Q9BY84
SAPAPKLALRETPAP	ITSN1	821	Q15811
PAARPPKEVPASRLA	CRAMP1	656	Q96RY5
PVLKSPTIPFFDPQI	CSN2	116	P05814
PSRIAAKLAFLPPEP	ABHD17C	26	Q6PCB6
RKPQAPARPLIFKSP	AKNA	386	Q7Z591
PPPSRAAQPADLLKV	COL5A1	31	P20908
PKPEALLARRSLQPP	MAST4	2081	O15021
PPAAPTRPSALELKV	FMNL1	466	O95466
RAQFEPNLVPKPPRL	DAGLA	961	Q9Y4D2
PNLVPKPPRLFAGSA	DAGLA	966	Q9Y4D2
ILKVRQEHFSPPPAP	INO80D	186	Q53TQ3
FARKPPRFSCLLPDP	GBF1	676	Q92538
GLIRKPIFDNFRPPP	KMT2A	641	Q03164
ILVAPEALPKAPSAP	IGFN1	736	Q86VF2
QLEPFEKFPERAPAP	FIGNL2	341	A6NMB9
QPQARDKPPPIALIA	HOMEZ	256	Q8IX15
PLLNSVRLAPPPVIK	COL13A1	241	Q5TAT6
ALAPGNRPLSFRKPP	FCRLB	306	Q6BAA4
APALALKLPIPSPQR	HIRA	676	P54198
VTTPFPALPQPKALL	BICRA	946	Q9NZM4
AAAPPLPRALAKPAV	DHX37	221	Q8IY37
LLAPEKQAQVFKPPP	DHX37	596	Q8IY37
KPPRPFSALIEDSIP	PKD1L1	2391	Q8TDX9
PKTLEFLPRPRPSAN	MAP3K9	986	P80192
DNLKECLFVPLPPSP	NPIPB9	316	F8W1W9
ERLVPVSPLPPKAAL	MOCS3	41	O95396
FLKAPPAPALTLAPV	CDH16	656	O75309
APPDFLPNTQKSPVR	COL6A6	2016	A6NMZ7
NSIDPKQPPRPFRSF	COL6A6	2186	A6NMZ7
RVRFPNLFPPLKPET	DHRS3	231	O75911
VPADKARPPAVPLLL	FRAT2	81	O75474
PPPKSPLRLIANAIR	MICAL2	1526	O94851
PDPLEKPNRPDTSFI	OTOF	1931	Q9HC10
QTRLEPPFPALVPKS	PRR14L	1941	Q5THK1
PRPSDKLNPKTINPF	PACRGL	56	Q8N7B6
ALFLIPRNPPPRLKS	MINK1	241	Q8N4C8
RVPLKPYAAPVPRSQ	MINK1	586	Q8N4C8
NPFSEDVKRPPAPLV	RETSAT	31	Q6NUM9
PRLPAPQIVAVKAPN	TAF4B	86	Q92750
FPVRDEKEPNPFLLP	SZT2	2711	Q5T011
IPALSPLLPEEARPK	SEZ6L	96	Q9BYH1
SDLRPPPQNPRKLIL	SLITRK6	356	Q9H5Y7
ELNPNFQPPKRPFKR	NARS1	376	O43776
VQSAKIDPPLAPLPR	FER1L5	6	A0AVI2
SQVPAAPAHPPLRKA	PLEKHG4	661	Q58EX7
PPKRSPSPEHENFLL	HIF3A	591	Q9Y2N7
EKLALLPPQARAPHP	PPP1R35	181	Q8TAP8
LKAVLPPPATQAPRT	PTCH2	766	Q9Y6C5
PLPRFAPLVKTEPQR	MPIG6B	176	O95866
FPQLGATPFPRKPLQ	PRAM1	131	Q96QH2
ADRDPNPPKRPLIFD	POLR3A	1366	O14802
DFCPPAPNPVLVRKS	SPATA31D4	646	Q6ZUB0
PPFLQKPLSILAPAT	DIP2C-AS1	151	Q8N8Z3
PPPRLVPFLDALKNH	INTS5	466	Q6P9B9
KPIALRQSQALPPRP	MTA1	686	Q13330
AASIFVAPKRPCPLP	NPAP1	61	Q9NZP6
PPLSNPDPRLLFKLS	OMA1	466	Q96E52
LFTPLKERPDLPPIQ	SEC23A	41	Q15436
RLRNAADLPPPLPNK	AFAP1L1	106	Q8TED9
VLSPAPRPLPKNFLL	CLP1	401	Q92989
LRFKLAPDHSRPPQP	CYP4Z1	471	Q86W10
QSPKRPPSPIKFDLN	UBA6	736	A0AVT1
DFCPPAPNPVLVRKS	SPATA31D3	646	P0C874
LPAADPFALAPFPSK	nan	336	Q6ZSR9
IKIAQPSYPPARPAS	SYNPO2	806	Q9UMS6
PDIRQKPPIFGPIFT	ERVFRD-1	101	P60508
PASPLVPFLQKFAEP	SNX14	311	Q9Y5W7
LPPFSKAPAAPLQAI	RREB1	486	Q92766
AVRPQSVFVSPPPKD	SH3PXD2A	976	Q5TCZ1
KPDATPQNPFLKSRP	SH3PXD2B	626	A1X283
PKFLPISSTPQPERR	SPIRE1	501	Q08AE8
NFPPAVNRVSPVRPK	SPATA31D1	1286	Q6ZQQ2
PPPPQLRLLDFLQKR	SUPT20H	256	Q8NEM7
FRINLPDKNVPPPSI	TMEM51	216	Q9NW97
PTQEPIFPPELLRLK	XDH	206	P47989
PSPVTRVLLKAPPAF	IGSF9	406	Q9P2J2
LTDEKLFALPPQPAP	nan	406	Q6ZUG5
PLPAPRRPKVNSILN	RALGAPB	431	Q86X10
CKPPPPAQEFQTARL	RALGAPB	1096	Q86X10
RFLPDEARSLPPPKL	NDUFC2-KCTD14	11	E9PQ53
LPALQVVPAKRVPAP	ZNF839	66	A8K0R7
DPAISVAPARAQPPK	ZNF688	141	P0C7X2
KAPEPPPALIVRNAV	YTHDC2	796	Q9H6S0
KPPFLRPELLDRAAP	ZDHHC8	266	Q9ULC8
DFKRIQLEPLPPLTP	TUT7	981	Q5VYS8
APEKARAFLPPASAP	SOX14	121	O95416
LPRPKDPVIPSIQLF	TGFBR3	421	Q03167
APVARQLAPREKPPL	USP17L10	56	C9JJH3
ATPQPDILPKRTFPE	ZNF114	56	Q8NC26
PPKVRQRIPFDLPSA	ZRANB3	266	Q5FWF4
EPPLSKRNPPALRLA	ZIC5	26	Q96T25
PDPFLKPRCPSLDNL	KMT2D	2241	O14686