Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpeptide lactyltransferase (CoA-dependent) activity

CREBBP EP300

5.90e-062492GO:0120300
GeneOntologyMolecularFunctionhistone H3K27 acetyltransferase activity

CREBBP EP300

5.90e-062492GO:0044017
GeneOntologyMolecularFunctionhistone H3K18 acetyltransferase activity

CREBBP EP300

1.77e-053492GO:0043993
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

KCNQ5 KCNJ8 KCNQ2 KCNG3

1.14e-04102494GO:0005249
GeneOntologyMolecularFunctionpotassium channel activity

KCNQ5 KCNJ8 KCNQ2 KCNG3

2.73e-04128494GO:0005267
GeneOntologyMolecularFunctiontranscription coactivator binding

FLYWCH1 CREBBP EP300

3.15e-0454493GO:0001223
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

NRG1 FLYWCH1 DTX1 IQCB1 GNB4 WWTR1 MSL1 CREBBP EP300 MAPK8IP3

4.34e-0411604910GO:0030674
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

KCNQ5 KCNJ8 KCNQ2 KCNG3

5.24e-04152494GO:0022843
GeneOntologyMolecularFunctionhistone H3 acetyltransferase activity

CREBBP EP300

6.07e-0415492GO:0010484
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

KCNQ5 KCNJ8 KCNQ2 KCNG3

7.46e-04167494GO:0015079
GeneOntologyMolecularFunctionJUN kinase binding

PTK2 MAPK8IP3

7.84e-0417492GO:0008432
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

KCNQ5 KCNJ8

7.84e-0417492GO:0099508
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

KCNQ5 KCNJ8 KCNQ2 KCNG3

1.03e-03182494GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

KCNQ5 KCNJ8 KCNQ2 KCNG3

1.07e-03184494GO:0022832
GeneOntologyMolecularFunctionperoxisome proliferator activated receptor binding

CREBBP EP300

1.20e-0321492GO:0042975
GeneOntologyMolecularFunctiongated channel activity

KCNQ5 KCNJ8 KCNQ2 TRPM8 KCNG3

1.33e-03334495GO:0022836
GeneOntologyMolecularFunctionmolecular adaptor activity

NRG1 FLYWCH1 DTX1 IQCB1 GNB4 WWTR1 MSL1 CREBBP EP300 MAPK8IP3

1.45e-0313564910GO:0060090
GeneOntologyMolecularFunctionmonoatomic cation channel activity

KCNQ5 KCNJ8 KCNQ2 TRPM8 KCNG3

1.49e-03343495GO:0005261
GeneOntologyMolecularFunctiontranscription coregulator activity

NRG1 FLYWCH1 DTX1 WWTR1 CREBBP EP300

2.42e-03562496GO:0003712
GeneOntologyMolecularFunctionbHLH transcription factor binding

CREBBP EP300

3.72e-0337492GO:0043425
GeneOntologyMolecularFunctiontranscription coregulator binding

FLYWCH1 CREBBP EP300

4.91e-03140493GO:0001221
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase binding

PTPN13 PTK2

5.00e-0343492GO:0043548
GeneOntologyMolecularFunctionprotein kinase binding

NRG1 KIDINS220 APBA1 IQSEC1 EP300 PTK2 MAPK8IP3

5.16e-03873497GO:0019901
GeneOntologyMolecularFunctionmonoatomic ion channel activity

KCNQ5 KCNJ8 KCNQ2 TRPM8 KCNG3

5.21e-03459495GO:0005216
GeneOntologyMolecularFunctionprotein domain specific binding

PALS1 KIDINS220 DTX1 APBA1 AFDN CREBBP PTK2

5.22e-03875497GO:0019904
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

KCNQ5 KCNJ8 KCNQ2 TRPM8 KCNG3

5.50e-03465495GO:0046873
GeneOntologyMolecularFunctiontranscription coactivator activity

DTX1 WWTR1 CREBBP EP300

6.44e-03303494GO:0003713
GeneOntologyMolecularFunctionhistone acetyltransferase activity

CREBBP EP300

6.97e-0351492GO:0004402
GeneOntologyMolecularFunctionsignaling receptor complex adaptor activity

GNB4 MAPK8IP3

7.78e-0354492GO:0030159
GeneOntologyMolecularFunctionchromatin DNA binding

H3Y1 CREBBP EP300

7.99e-03167493GO:0031490
GeneOntologyMolecularFunctionpeptide-lysine-N-acetyltransferase activity

CREBBP EP300

8.06e-0355492GO:0061733
GeneOntologyBiologicalProcesshead development

ATRN NRG1 PALS1 ROGDI IER3IP1 ASPM KCNQ2 AFDN GNB4 CREBBP EP300 MAPK8IP3

5.46e-079194612GO:0060322
GeneOntologyBiologicalProcessneuron development

TANC2 NRG1 PALS1 KANK1 KIDINS220 HECW2 IQSEC1 KCNQ2 AFDN CREBBP EP300 PTK2 MAPK8IP3

1.21e-0514634613GO:0048666
GeneOntologyBiologicalProcessbrain development

ATRN NRG1 PALS1 ROGDI IER3IP1 ASPM KCNQ2 AFDN GNB4 MAPK8IP3

1.55e-058594610GO:0007420
GeneOntologyBiologicalProcessdevelopmental growth

ATRN NRG1 IER3IP1 KCNJ8 APBA1 ASPM AFDN WWTR1 EP300 PTK2

2.57e-059114610GO:0048589
GeneOntologyBiologicalProcessN-terminal peptidyl-lysine acetylation

CREBBP EP300

2.91e-054462GO:0018076
GeneOntologyBiologicalProcesscentral nervous system development

ATRN NRG1 PALS1 ROGDI IER3IP1 ASPM KCNQ2 AFDN GNB4 PTK2 MAPK8IP3

4.88e-0511974611GO:0007417
GeneOntologyBiologicalProcessregulation of neuron projection development

TANC2 NRG1 KANK1 KIDINS220 HECW2 AFDN EP300 PTK2

5.53e-05612468GO:0010975
GeneOntologyBiologicalProcesssynapse assembly

NRG1 PTPN13 KCNJ8 IQSEC1 AFDN PTK2

5.98e-05308466GO:0007416
GeneOntologyBiologicalProcessgrowth

ATRN NRG1 IER3IP1 KCNJ8 APBA1 ASPM AFDN WWTR1 EXOSC2 EP300 PTK2

6.49e-0512354611GO:0040007
GeneOntologyBiologicalProcessregulation of synapse assembly

NRG1 PTPN13 IQSEC1 AFDN PTK2

8.48e-05202465GO:0051963
GeneOntologyBiologicalProcessneuron projection development

TANC2 NRG1 KANK1 KIDINS220 HECW2 IQSEC1 AFDN CREBBP EP300 PTK2 MAPK8IP3

9.27e-0512854611GO:0031175
GeneOntologyBiologicalProcessdendrite development

TANC2 KIDINS220 HECW2 IQSEC1 AFDN CREBBP

9.51e-05335466GO:0016358
GeneOntologyBiologicalProcessresponse to temperature stimulus

NRG1 KCNQ2 TRPM8 CREBBP EP300

9.73e-05208465GO:0009266
GeneOntologyBiologicalProcesspositive regulation of cell growth

NRG1 AFDN EXOSC2 EP300 PTK2

1.09e-04213465GO:0030307
GeneOntologyBiologicalProcessregulation of synapse organization

TANC2 NRG1 PTPN13 IQSEC1 AFDN PTK2

2.09e-04387466GO:0050807
GeneOntologyBiologicalProcessregulation of synapse structure or activity

TANC2 NRG1 PTPN13 IQSEC1 AFDN PTK2

2.33e-04395466GO:0050803
GeneOntologyBiologicalProcessresponse to exogenous dsRNA

COLEC12 KCNJ8 IFNA14

2.51e-0455463GO:0043330
GeneOntologyBiologicalProcessestablishment or maintenance of cell polarity

PALS1 KANK1 KCNJ8 KCNQ2 PTK2

2.61e-04257465GO:0007163
GeneOntologyBiologicalProcessdendritic spine development

TANC2 IQSEC1 AFDN CREBBP

2.73e-04141464GO:0060996
GeneOntologyBiologicalProcesspositive regulation of nervous system development

NRG1 ASPM IQSEC1 AFDN EP300 PTK2

3.15e-04418466GO:0051962
GeneOntologyBiologicalProcessresponse to dsRNA

COLEC12 KCNJ8 IFNA14

3.75e-0463463GO:0043331
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

TANC2 KANK1 KIDINS220 HECW2 AFDN EP300 PTK2 MAPK8IP3

4.08e-04819468GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

TANC2 KANK1 KIDINS220 HECW2 AFDN EP300 PTK2 MAPK8IP3

4.32e-04826468GO:0048858
GeneOntologyBiologicalProcessregulation of nervous system development

NRG1 PTPN13 ASPM IQSEC1 AFDN EP300 PTK2

4.35e-04625467GO:0051960
GeneOntologyBiologicalProcessnegative regulation of synapse assembly

PTPN13 PTK2

5.02e-0415462GO:0051964
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection organization

TANC2 NRG1 KANK1 KIDINS220 HECW2 AFDN EP300 PTK2

5.06e-04846468GO:0120035
GeneOntologyBiologicalProcessN-terminal protein amino acid acetylation

CREBBP EP300

5.72e-0416462GO:0006474
GeneOntologyBiologicalProcessregulation of cellular response to heat

CREBBP EP300

5.72e-0416462GO:1900034
GeneOntologyBiologicalProcessregulation of cell projection organization

TANC2 NRG1 KANK1 KIDINS220 HECW2 AFDN EP300 PTK2

5.77e-04863468GO:0031344
GeneOntologyBiologicalProcessregulation of cell junction assembly

NRG1 PTPN13 IQSEC1 AFDN PTK2

6.05e-04309465GO:1901888
GeneOntologyBiologicalProcessestablishment of cell polarity

KANK1 KCNJ8 KCNQ2 PTK2

6.46e-04177464GO:0030010
GeneOntologyBiologicalProcessforebrain development

NRG1 PALS1 ASPM KCNQ2 AFDN MAPK8IP3

7.22e-04489466GO:0030900
GeneOntologyBiologicalProcessmemory

NRG1 ROGDI KCNQ2 CREBBP

7.31e-04183464GO:0007613
GeneOntologyBiologicalProcesssynapse organization

TANC2 NRG1 PTPN13 KCNJ8 IQSEC1 AFDN PTK2

7.49e-04685467GO:0050808
GeneOntologyBiologicalProcesstelencephalon development

NRG1 PALS1 ASPM KCNQ2 AFDN

8.37e-04332465GO:0021537
GeneOntologyBiologicalProcesspositive regulation of growth

NRG1 AFDN EXOSC2 EP300 PTK2

9.18e-04339465GO:0045927
GeneOntologyBiologicalProcessdendrite morphogenesis

TANC2 KIDINS220 HECW2 AFDN

9.81e-04198464GO:0048813
GeneOntologyBiologicalProcessnegative regulation of synapse organization

PTPN13 PTK2

9.95e-0421462GO:1905809
GeneOntologyBiologicalProcesspeptidyl-tyrosine autophosphorylation

NRG1 PTK2

1.09e-0322462GO:0038083
GeneOntologyBiologicalProcessregulation of dendritic spine development

TANC2 AFDN CREBBP

1.10e-0391463GO:0060998
GeneOntologyBiologicalProcesspositive regulation of neurogenesis

NRG1 ASPM AFDN EP300 PTK2

1.11e-03354465GO:0050769
GeneOntologyBiologicalProcesscell morphogenesis

TANC2 NRG1 KANK1 KIDINS220 HECW2 AFDN EP300 PTK2 MAPK8IP3

1.12e-031194469GO:0000902
GeneOntologyBiologicalProcesspositive regulation of response to wounding

NRG1 KANK1 PTK2

1.17e-0393463GO:1903036
GeneOntologyBiologicalProcessstimulatory C-type lectin receptor signaling pathway

CREBBP EP300

1.19e-0323462GO:0002223
GeneOntologyBiologicalProcesscellular response to lectin

CREBBP EP300

1.19e-0323462GO:1990858
GeneOntologyBiologicalProcessresponse to lectin

CREBBP EP300

1.19e-0323462GO:1990840
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

TANC2 KIDINS220 HECW2 AFDN EP300 PTK2 MAPK8IP3

1.25e-03748467GO:0048667
GeneOntologyCellularComponentpresynaptic active zone membrane

NRG1 KCNJ8 APBA1 AFDN

3.63e-0578504GO:0048787
GeneOntologyCellularComponentvoltage-gated potassium channel complex

KCNQ5 KCNJ8 KCNQ2 KCNG3

6.64e-0591504GO:0008076
GeneOntologyCellularComponentpotassium channel complex

KCNQ5 KCNJ8 KCNQ2 KCNG3

1.12e-04104504GO:0034705
GeneOntologyCellularComponentpresynaptic active zone

NRG1 KCNJ8 APBA1 AFDN

3.59e-04141504GO:0048786
GeneOntologyCellularComponentpresynaptic membrane

NRG1 KCNQ5 KCNJ8 APBA1 AFDN

5.13e-04277505GO:0042734
GeneOntologyCellularComponentaxon

TANC2 NRG1 PALS1 ROGDI KCNQ5 KCNQ2 AFDN MAPK8IP3

1.16e-03891508GO:0030424
GeneOntologyCellularComponentnuclear body

FLYWCH1 PRPF40B DTX1 AFDN WWTR1 MSL1 CREBBP PTK2

1.26e-03903508GO:0016604
GeneOntologyCellularComponentmitotic spindle

HECW2 IQCB1 ASPM MAPKBP1

1.35e-03201504GO:0072686
GeneOntologyCellularComponenthistone acetyltransferase complex

MSL1 CREBBP EP300

1.48e-0394503GO:0000123
GeneOntologyCellularComponentprotein acetyltransferase complex

MSL1 CREBBP EP300

1.98e-03104503GO:0031248
GeneOntologyCellularComponentacetyltransferase complex

MSL1 CREBBP EP300

2.26e-03109503GO:1902493
GeneOntologyCellularComponentcation channel complex

KCNQ5 KCNJ8 KCNQ2 KCNG3

2.39e-03235504GO:0034703
HumanPhenoAortic isthmus hypoplasia

CREBBP EP300

1.46e-052202HP:0034227
HumanPhenoPlantar crease between first and second toes

CREBBP EP300

1.46e-052202HP:0008107
HumanPhenoHigh axial triradius

CREBBP EP300

1.46e-052202HP:0001042
HumanPhenoHumoral immunodeficiency

CREBBP EP300

4.38e-053202HP:0005363
HumanPhenoProminent nasal septum

CREBBP EP300

4.38e-053202HP:0005322
HumanPhenoRadial deviation of thumb terminal phalanx

CREBBP EP300

4.38e-053202HP:0005895
HumanPhenoLaryngeal cartilage malformation

CREBBP EP300

4.38e-053202HP:0008752
HumanPhenoPhobia

CREBBP EP300

4.38e-053202HP:5200232
HumanPhenoAgoraphobia

CREBBP EP300

4.38e-053202HP:0000756
HumanPhenoDelayed myelination

KIDINS220 IER3IP1 KCNQ2 CREBBP EXOSC2 EP300 MAPK8IP3

5.87e-05280207HP:0012448
HumanPhenoDeep plantar creases

KCNJ8 CREBBP EP300

6.58e-0521203HP:0001869
HumanPhenoTrichiasis

CREBBP EP300

8.75e-054202HP:0001128
HumanPhenoWidened distal phalanges

CREBBP EP300

8.75e-054202HP:0006200
HumanPhenoVisceral hemangioma

CREBBP EP300

8.75e-054202HP:0410266
HumanPhenoTalon cusp

CREBBP EP300

8.75e-054202HP:0011087
HumanPhenoVascular ring

CREBBP EP300

8.75e-054202HP:0010775
HumanPhenoHepatic hemangioma

CREBBP EP300

8.75e-054202HP:0031207
HumanPhenoBroad hallux phalanx

KCNJ8 CREBBP EP300

9.94e-0524203HP:0010059
HumanPhenoMinor feet anomalies

KCNJ8 CREBBP EP300

1.27e-0426203HP:0010613
HumanPhenoAbnormal feet morphology

KCNJ8 CREBBP EP300

1.27e-0426203HP:0010611
HumanPhenoBroad distal phalanx of finger

CREBBP EXOSC2 EP300

1.43e-0427203HP:0009836
HumanPhenoPapillary cystadenoma of the epididymis

CREBBP EP300

1.45e-045202HP:0009715
HumanPhenoSupernumerary cusp

CREBBP EP300

1.45e-045202HP:0033777
HumanPhenoEpididymal neoplasm

CREBBP EP300

1.45e-045202HP:0030421
HumanPhenoLarge foramen magnum

CREBBP EP300

2.18e-046202HP:0002700
HumanPhenoFull cheeks

KIDINS220 IER3IP1 CREBBP EP300 MAPK8IP3

2.32e-04151205HP:0000293
HumanPhenoThick eyebrow

HECW2 KCNJ8 CREBBP EP300 MAPK8IP3

2.54e-04154205HP:0000574
HumanPhenoDeviated nasal septum

CREBBP EP300

3.04e-047202HP:0004411
HumanPhenoDisturbance of facial expression

KCNQ2 CREBBP EP300

3.40e-0436203HP:0005324
HumanPhenoDeeply set eye

KIDINS220 HECW2 CREBBP EXOSC2 EP300 MAPK8IP3

3.99e-04266206HP:0000490
HumanPhenoPilomatrixoma

CREBBP EP300

5.19e-049202HP:0030434
HumanPhenoCervical cord compression

CREBBP EP300

5.19e-049202HP:0002341
HumanPhenoMotor delay

TANC2 ROGDI KIDINS220 HECW2 ASPM IQSEC1 KCNQ2 CREBBP EXOSC2 EP300 MAPK8IP3

5.44e-0410182011HP:0001270
HumanPhenoFrontal hirsutism

CREBBP EP300

6.47e-0410202HP:0011335
HumanPhenoAbnormal hallux phalanx morphology

KCNJ8 CREBBP EP300

7.06e-0446203HP:0010057
HumanPhenoBroad phalanx of the toes

KCNJ8 CREBBP EP300

7.52e-0447203HP:0010174
HumanPhenoAbnormal subclavian artery morphology

CREBBP EP300

7.89e-0411202HP:0031251
HumanPhenoDelayed ability to walk

ROGDI HECW2 IQSEC1 CREBBP EP300 MAPK8IP3

8.16e-04304206HP:0031936
HumanPhenoFacial grimacing

CREBBP EP300

1.11e-0313202HP:0000273
HumanPhenoKeloids

CREBBP EP300

1.11e-0313202HP:0010562
HumanPhenoParietal foramina

CREBBP EP300

1.30e-0314202HP:0002697
HumanPhenoDuplication of phalanx of hallux

CREBBP EP300

1.30e-0314202HP:0010066
HumanPhenoHypoplastic aortic arch

CREBBP EP300

1.30e-0314202HP:0012304
HumanPhenoAbnormal lateral ventricle morphology

KIDINS220 ASPM CREBBP EP300

1.39e-03129204HP:0030047
HumanPhenoSocial and occupational deterioration

CREBBP EP300

1.49e-0315202HP:0007086
HumanPhenoDuplication of phalanx of toe

CREBBP EP300

1.49e-0315202HP:0010181
HumanPhenoAbnormal myelination

KIDINS220 IER3IP1 KCNQ2 GNB4 CREBBP EXOSC2 EP300 MAPK8IP3

1.55e-03622208HP:0012447
HumanPhenoDelayed gross motor development

ROGDI KIDINS220 HECW2 IQSEC1 CREBBP EP300 MAPK8IP3

1.67e-03481207HP:0002194
HumanPhenoSquare face

CREBBP EP300

1.70e-0316202HP:0000321
HumanPhenoPremature thelarche

CREBBP EP300

1.92e-0317202HP:0010314
MousePhenoabnormal synaptic transmission

TANC2 COLEC12 NRG1 KANK1 KIDINS220 DTX1 KCNJ8 APBA1 IQSEC1 KCNQ2 AFDN CREBBP MAPK8IP3

1.20e-0510704313MP:0003635
MousePhenoabnormal synaptic physiology

TANC2 COLEC12 NRG1 KANK1 KIDINS220 DTX1 KCNJ8 APBA1 IQSEC1 KCNQ2 AFDN CREBBP MAPK8IP3

1.28e-0510764313MP:0021009
MousePhenoabnormal CNS synaptic transmission

TANC2 COLEC12 NRG1 KANK1 KIDINS220 DTX1 APBA1 IQSEC1 KCNQ2 AFDN CREBBP MAPK8IP3

2.78e-059854312MP:0002206
DomainNuc_rcpt_coact_CREBbp

CREBBP EP300

6.74e-062492IPR014744
DomainHAT_KAT11

CREBBP EP300

6.74e-062492PF08214
DomainKIX

CREBBP EP300

6.74e-062492PS50952
DomainZnF_TAZ

CREBBP EP300

6.74e-062492SM00551
DomainCBP_P300_HAT

CREBBP EP300

6.74e-062492IPR031162
DomainDUF902

CREBBP EP300

6.74e-062492PF06001
DomainK_chnl_volt-dep_KCNQ2

KCNQ5 KCNQ2

6.74e-062492IPR003947
Domain-

CREBBP EP300

6.74e-0624921.20.1020.10
DomainRING_CBP-p300

CREBBP EP300

6.74e-062492IPR010303
Domain-

CREBBP EP300

6.74e-0624921.10.1630.10
DomainCreb_binding

CREBBP EP300

6.74e-062492PF09030
Domain-

CREBBP EP300

6.74e-0624921.10.246.20
Domainzf-TAZ

CREBBP EP300

6.74e-062492PF02135
DomainZF_TAZ

CREBBP EP300

6.74e-062492PS50134
DomainHistone_AcTrfase_Rtt109/CBP

CREBBP EP300

6.74e-062492IPR013178
DomainKAT11

CREBBP EP300

6.74e-062492SM01250
DomainZnf_TAZ

CREBBP EP300

6.74e-062492IPR000197
DomainKIX_dom

CREBBP EP300

6.74e-062492IPR003101
DomainKIX

CREBBP EP300

6.74e-062492PF02172
DomainCBP_P300_HAT

CREBBP EP300

6.74e-062492PS51727
DomainPDZ

PALS1 PTPN13 APBA1 AFDN PDZRN4

3.33e-05141495PF00595
DomainPDZ

PALS1 PTPN13 APBA1 AFDN PDZRN4

4.20e-05148495SM00228
Domain-

PALS1 PTPN13 APBA1 AFDN PDZRN4

4.48e-051504952.30.42.10
DomainPDZ

PALS1 PTPN13 APBA1 AFDN PDZRN4

4.63e-05151495PS50106
DomainPDZ

PALS1 PTPN13 APBA1 AFDN PDZRN4

4.78e-05152495IPR001478
DomainK_chnl_volt-dep_KCNQ

KCNQ5 KCNQ2

6.71e-055492IPR003937
DomainK_chnl_volt-dep_KCNQ_C

KCNQ5 KCNQ2

6.71e-055492IPR013821
DomainKCNQ_channel

KCNQ5 KCNQ2

6.71e-055492PF03520
DomainVG_K_chnl

KCNQ5 KCNQ2 KCNG3

8.76e-0533493IPR028325
DomainNuc_rcpt_coact

CREBBP EP300

1.00e-046492IPR009110
DomainIon_trans_dom

KCNQ5 KCNQ2 TRPM8 KCNG3

2.26e-04114494IPR005821
DomainIon_trans

KCNQ5 KCNQ2 TRPM8 KCNG3

2.26e-04114494PF00520
DomainWW

PRPF40B HECW2 WWTR1

2.54e-0447493PF00397
DomainWW

PRPF40B HECW2 WWTR1

2.70e-0448493SM00456
DomainWW_DOMAIN_2

PRPF40B HECW2 WWTR1

3.23e-0451493PS50020
DomainWW_DOMAIN_1

PRPF40B HECW2 WWTR1

3.23e-0451493PS01159
DomainWW_dom

PRPF40B HECW2 WWTR1

3.43e-0452493IPR001202
DomainIQ

IQCB1 ASPM IQSEC1

8.56e-0471493PF00612
DomainZZ

CREBBP EP300

1.00e-0318492PF00569
DomainZF_ZZ_2

CREBBP EP300

1.00e-0318492PS50135
DomainZF_ZZ_1

CREBBP EP300

1.00e-0318492PS01357
DomainZnf_ZZ

CREBBP EP300

1.12e-0319492IPR000433
DomainZnF_ZZ

CREBBP EP300

1.12e-0319492SM00291
DomainIQ_motif_EF-hand-BS

IQCB1 ASPM IQSEC1

1.70e-0390493IPR000048
DomainIQ

IQCB1 ASPM IQSEC1

1.87e-0393493PS50096
DomainBromodomain_CS

CREBBP EP300

2.11e-0326492IPR018359
DomainBROMODOMAIN_1

CREBBP EP300

4.24e-0337492PS00633
DomainBromodomain

CREBBP EP300

4.46e-0338492PF00439
DomainPH_dom-like

PTPN13 PLEKHA4 APBA1 IQSEC1 PTK2

5.04e-03426495IPR011993
DomainBROMODOMAIN_2

CREBBP EP300

5.18e-0341492PS50014
PathwayREACTOME_POTASSIUM_CHANNELS

KCNQ5 KCNJ8 KCNQ2 GNB4 KCNG3

5.15e-06103355M1073
PathwayWP_PATHOPHYSIOLOGICAL_ROLES_OF_DUX4_IN_FSHD1

H3Y2 H3Y1 EP300

1.12e-0518353M48069
PathwayREACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION

CREBBP EP300 IFNA14

5.44e-0530353M936
PathwayREACTOME_NEURONAL_SYSTEM

NRG1 KCNQ5 KCNJ8 APBA1 KCNQ2 GNB4 KCNG3

5.64e-05411357M735
PathwayBIOCARTA_PELP1_PATHWAY

CREBBP EP300

5.96e-055352MM1575
PathwayREACTOME_NFE2L2_REGULATING_INFLAMMATION_ASSOCIATED_GENES

CREBBP EP300

5.96e-055352M48020
PathwayREACTOME_NFE2L2_REGULATING_ER_STRESS_ASSOCIATED_GENES

CREBBP EP300

5.96e-055352M48023
PathwayREACTOME_LRR_FLII_INTERACTING_PROTEIN_1_LRRFIP1_ACTIVATES_TYPE_I_IFN_PRODUCTION

CREBBP EP300

5.96e-055352M27228
PathwayREACTOME_EVASION_BY_RSV_OF_HOST_INTERFERON_RESPONSES

CREBBP EP300 IFNA14

8.69e-0535353M48246
PathwayBIOCARTA_PELP1_PATHWAY

CREBBP EP300

8.93e-056352M22062
PathwayREACTOME_POTASSIUM_CHANNELS

KCNQ5 KCNJ8 GNB4 KCNG3

9.75e-0598354MM14545
PathwayBIOCARTA_PPARG_PATHWAY

CREBBP EP300

1.25e-047352MM1573
PathwayREACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

KCNQ5 KCNQ2 KCNG3

1.62e-0443353M1056
PathwayBIOCARTA_PPARG_PATHWAY

CREBBP EP300

1.66e-048352M22058
PathwayREACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES

CREBBP EP300

1.66e-048352M48022
PathwayREACTOME_REGULATION_OF_NFE2L2_GENE_EXPRESSION

CREBBP EP300

1.66e-048352M48024
PathwayREACTOME_NFE2L2_REGULATES_PENTOSE_PHOSPHATE_PATHWAY_GENES

CREBBP EP300

1.66e-048352M46443
PathwayREACTOME_ESR_MEDIATED_SIGNALING

KANK1 GNB4 CREBBP EP300 PTK2

1.96e-04220355M27794
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

DTX1 CREBBP EP300

2.11e-0447353M7946
PathwayKEGG_MEDICUS_REFERENCE_TLR3_IRF3_SIGNALING_PATHWAY

CREBBP EP300

2.13e-049352M47451
PathwayREACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION

CREBBP EP300

2.66e-0410352M27945
PathwayBIOCARTA_CARM1_PATHWAY

CREBBP EP300

3.25e-0411352MM1521
PathwayREACTOME_NFE2L2_REGULATING_TUMORIGENIC_GENES

CREBBP EP300

3.25e-0411352M48021
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_BY_HYPOXIA_INDUCIBLE_FACTOR

CREBBP EP300

3.25e-0411352M26924
PathwayBIOCARTA_CARM1_PATHWAY

CREBBP EP300

3.89e-0412352M7968
PathwayREACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS

CREBBP EP300

3.89e-0412352M27765
PathwayREACTOME_RUNX3_REGULATES_NOTCH_SIGNALING

CREBBP EP300

5.35e-0414352M27808
PathwayBIOCARTA_RELA_PATHWAY

CREBBP EP300

6.16e-0415352MM1339
PathwayBIOCARTA_RELA_PATHWAY

CREBBP EP300

6.16e-0415352M10183
PathwayBIOCARTA_PITX2_PATHWAY

CREBBP EP300

6.16e-0415352MM1439
PathwayREACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY

CREBBP EP300

6.16e-0415352M953
PathwayBIOCARTA_RACC_PATHWAY

KCNQ5 KCNQ2

6.16e-0415352M22002
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS

CREBBP EP300

7.03e-0416352M27121
PathwayBIOCARTA_IL7_PATHWAY

CREBBP EP300

7.03e-0416352M1296
PathwayBIOCARTA_IL7_PATHWAY

CREBBP EP300

7.03e-0416352MM1420
PathwayBIOCARTA_PITX2_PATHWAY

CREBBP EP300

7.03e-0416352M8516
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_DEATH_GENES

CREBBP EP300

7.03e-0416352M27940
PathwayREACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS

KANK1 GNB4 CREBBP EP300 PTK2

7.64e-04296355M27869
PathwayKEGG_ADHERENS_JUNCTION

AFDN CREBBP EP300

7.74e-0473353M638
PathwayBIOCARTA_TGFB_PATHWAY

CREBBP EP300

7.96e-0417352MM1509
PathwayREACTOME_ZYGOTIC_GENOME_ACTIVATION_ZGA

CREBBP EP300

7.96e-0417352M48025
PathwayREACTOME_SIGNALING_BY_NOTCH1

DTX1 CREBBP EP300

8.05e-0474353M616
PathwayREACTOME_RORA_ACTIVATES_GENE_EXPRESSION

CREBBP EP300

8.94e-0418352M26942
PathwayREACTOME_SIGNALING_BY_NOTCH1

DTX1 EP300

8.94e-0418352MM14775
PathwayBIOCARTA_TGFB_PATHWAY

CREBBP EP300

9.97e-0419352M18933
PathwayREACTOME_NFE2L2_REGULATING_ANTI_OXIDANT_DETOXIFICATION_ENZYMES

CREBBP EP300

9.97e-0419352M46442
PathwayREACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA

CREBBP EP300 IFNA14

1.09e-0382353M1002
PathwayREACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

CREBBP EP300

1.11e-0320352M27881
PathwayWP_HEMATOPOIETIC_STEM_CELL_GENE_REGULATION_BY_GABP_ALPHABETA_COMPLEX

CREBBP EP300

1.22e-0321352M39593
PathwayREACTOME_CD209_DC_SIGN_SIGNALING

CREBBP EP300

1.22e-0321352M27485
PathwayREACTOME_NEURONAL_SYSTEM

KCNQ5 KCNJ8 APBA1 GNB4 KCNG3

1.33e-03335355MM14503
PathwayBIOCARTA_VDR_PATHWAY

CREBBP EP300

1.34e-0322352MM1370
PathwayBIOCARTA_NTHI_PATHWAY

CREBBP EP300

1.34e-0322352MM1443
PathwayBIOCARTA_NTHI_PATHWAY

CREBBP EP300

1.47e-0323352M2821
PathwayWP_ANDROGEN_RECEPTOR_SIGNALING

CREBBP EP300 PTK2

1.47e-0391353M39700
PathwayWP_ANGIOGENESIS

CREBBP PTK2

1.60e-0324352M39556
PathwayBIOCARTA_VDR_PATHWAY

CREBBP EP300

1.60e-0324352M13404
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3

WWTR1 CREBBP EP300

1.71e-0396353M27784
PathwayREACTOME_NOTCH3_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

CREBBP EP300

1.73e-0325352M27880
PathwayREACTOME_RSV_HOST_INTERACTIONS

CREBBP EP300 IFNA14

1.81e-0398353M48247
PathwayBIOCARTA_CARM_ER_PATHWAY

CREBBP EP300

1.87e-0326352M2499
PathwayPID_HDAC_CLASSIII_PATHWAY

CREBBP EP300

1.87e-0326352M32
PathwayWP_IL6_SIGNALING_PATHWAY

CREBBP EP300 PTK2

1.92e-03100353MM15826
PathwayREACTOME_ATTENUATION_PHASE

CREBBP EP300

2.17e-0328352M27254
PathwayPID_RETINOIC_ACID_PATHWAY

CREBBP EP300

2.49e-0330352M207
PathwayPID_NECTIN_PATHWAY

AFDN PTK2

2.49e-0330352M72
PathwayKEGG_MEDICUS_REFERENCE_CXCR4_GNB_G_PLCB_PKC_SIGNALING_PATHWAY

GNB4 PTK2

2.66e-0331352M47554
PathwayWP_INITIATION_OF_TRANSCRIPTION_AND_TRANSLATION_ELONGATION_AT_THE_HIV1_LTR

CREBBP EP300

2.83e-0332352M39521
PathwayWP_PRION_DISEASE_PATHWAY

EP300 PTK2

2.83e-0332352M39636
PathwayWP_TYPE_2_PAPILLARY_RENAL_CELL_CARCINOMA

CREBBP EP300

3.20e-0334352M39771
PathwayPID_HIF2PATHWAY

CREBBP EP300

3.20e-0334352M44
PathwayREACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_PATHWAY

CREBBP EP300 IFNA14

3.23e-03120353M48233
PathwayREACTOME_INWARDLY_RECTIFYING_K_CHANNELS

KCNJ8 GNB4

3.38e-0335352M1075
PathwayREACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION

WWTR1 EP300

3.58e-0336352M633
PathwayREACTOME_INWARDLY_RECTIFYING_K_CHANNELS

KCNJ8 GNB4

3.58e-0336352MM14544
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_THE_AP_2_TFAP2_FAMILY_OF_TRANSCRIPTION_FACTORS

CREBBP EP300

3.98e-0338352M27757
PathwayREACTOME_HSF1_DEPENDENT_TRANSACTIVATION

CREBBP EP300

3.98e-0338352M27255
PathwayREACTOME_SIGNALING_BY_NOTCH

DTX1 EP300

4.19e-0339352MM14604
PathwayREACTOME_ESR_MEDIATED_SIGNALING

GNB4 EP300 PTK2

4.31e-03133353MM15529
PathwayPID_FOXM1_PATHWAY

CREBBP EP300

4.40e-0340352M176
PathwayPID_IFNG_PATHWAY

CREBBP EP300

4.40e-0340352M161
PathwayREACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

KCNQ5 KCNG3

4.62e-0341352MM14546
PathwayREACTOME_RND1_GTPASE_CYCLE

PTPN13 KIDINS220

4.84e-0342352M41828
PathwayREACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT

CREBBP EP300

4.84e-0342352M17541
PathwayREACTOME_RND2_GTPASE_CYCLE

PTPN13 KIDINS220

5.07e-0343352M41827
PathwayREACTOME_RND1_GTPASE_CYCLE

PTPN13 KIDINS220

5.07e-0343352MM15679
PathwayREACTOME_HATS_ACETYLATE_HISTONES

MSL1 CREBBP EP300

5.17e-03142353M27233
PathwayPID_HNF3A_PATHWAY

CREBBP EP300

5.31e-0344352M285
PathwayREACTOME_RND2_GTPASE_CYCLE

PTPN13 KIDINS220

5.31e-0344352MM15678
PathwayREACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS

CREBBP EP300

5.31e-0344352M27295
Pubmed

A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome.

WWTR1 CREBBP EP300

1.04e-07751316332960
Pubmed

Loss of p300 accelerates MDS-associated leukemogenesis.

CREBBP EP300

2.11e-06251227881875
Pubmed

Molecular characterization of the histone acetyltransferase CREBBP/EP300 genes in myeloid neoplasia.

CREBBP EP300

2.11e-06251234845315
Pubmed

The role of PTPN13 in invasion and metastasis of lung squamous cell carcinoma.

PTPN13 PTK2

2.11e-06251223906871
Pubmed

p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts.

CREBBP EP300

2.11e-06251219729597
Pubmed

Endogenous CCAAT/enhancer binding protein beta and p300 are both regulated by growth hormone to mediate transcriptional activation.

CREBBP EP300

2.11e-06251215860545
Pubmed

Further delineation of an entity caused by CREBBP and EP300 mutations but not resembling Rubinstein-Taybi syndrome.

CREBBP EP300

2.11e-06251229460469
Pubmed

Expression of p300 and CBP is associated with poor prognosis in small cell lung cancer.

CREBBP EP300

2.11e-06251224551300
Pubmed

Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma.

CREBBP EP300

2.11e-06251233911074
Pubmed

The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300.

CREBBP EP300

2.11e-0625129018065
Pubmed

Coactivators p300 and CBP maintain the identity of mouse embryonic stem cells by mediating long-range chromatin structure.

CREBBP EP300

2.11e-06251224648406
Pubmed

CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity.

CREBBP EP300

2.11e-06251230135524
Pubmed

CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer.

CREBBP EP300

2.11e-06251239287984
Pubmed

Distribution of co-activators CBP and p300 during mouse oocyte and embryo development.

CREBBP EP300

2.11e-06251216596650
Pubmed

KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3.

KCNQ5 KCNQ2

2.11e-06251235320039
Pubmed

The p300 and CBP Transcriptional Coactivators Are Required for β-Cell and α-Cell Proliferation.

CREBBP EP300

2.11e-06251229217654
Pubmed

Exon deletions of the EP300 and CREBBP genes in two children with Rubinstein-Taybi syndrome detected by aCGH.

CREBBP EP300

2.11e-06251220717166
Pubmed

Differences in the interactions of oncogenic adenovirus 12 early region 1A and nononcogenic adenovirus 2 early region 1A with the cellular coactivators p300 and CBP.

CREBBP EP300

2.11e-06251210049825
Pubmed

CBP/p300 acetyltransferase activity in hematologic malignancies.

CREBBP EP300

2.11e-06251227380996
Pubmed

CREBBP and p300 lysine acetyl transferases in the DNA damage response.

CREBBP EP300

2.11e-06251229170789
Pubmed

The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.

CREBBP EP300

2.11e-06251225893291
Pubmed

Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300.

CREBBP EP300

2.11e-06251211559821
Pubmed

Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis.

CREBBP EP300

2.11e-06251221555743
Pubmed

CBP/p300 induction is required for retinoic acid sensitivity in human mammary cells.

CREBBP EP300

2.11e-06251212646247
Pubmed

CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.

CREBBP EP300

2.11e-06251232576962
Pubmed

Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology.

CREBBP EP300

2.11e-06251219822209
Pubmed

A specific CBP/p300-dependent gene expression programme drives the metabolic remodelling in late stages of spermatogenesis.

CREBBP EP300

2.11e-06251224522976
Pubmed

Histone acetyltransferase activities of cAMP-regulated enhancer-binding protein and p300 in tissues of fetal, young, and old mice.

CREBBP EP300

2.11e-06251211867645
Pubmed

CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.

CREBBP EP300

2.11e-06251221847097
Pubmed

Expression of the nuclear coactivators CBP and p300 in developing craniofacial tissue.

CREBBP EP300

2.11e-06251211963968
Pubmed

p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes.

CREBBP EP300

2.11e-06251234813504
Pubmed

Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300.

CREBBP EP300

2.11e-0625129528808
Pubmed

Analysis of genetic stability at the EP300 and CREBBP loci in a panel of cancer cell lines.

CREBBP EP300

2.11e-06251212696060
Pubmed

Rubinstein-Taybi Syndrome

CREBBP EP300

2.11e-06251220301699
Pubmed

CBP Is Required for Establishing Adaptive Gene Programs in the Adult Mouse Brain.

CREBBP EP300

2.11e-06251236109165
Pubmed

Potential biomarker of metformin action.

CREBBP EP300

2.11e-06251224639469
Pubmed

The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels.

CREBBP EP300

2.11e-06251237816914
Pubmed

Retinoids and retinoic acid receptors regulate growth arrest and apoptosis in human mammary epithelial cells and modulate expression of CBP/p300.

CREBBP EP300

2.11e-06251212242694
Pubmed

Binding of p300/CBP co-activators by polyoma large T antigen.

CREBBP EP300

2.11e-06251211438528
Pubmed

Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators.

CREBBP EP300

2.11e-06251210918613
Pubmed

CBP/p300 Drives the Differentiation of Regulatory T Cells through Transcriptional and Non-Transcriptional Mechanisms.

CREBBP EP300

2.11e-06251231182547
Pubmed

Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity.

CREBBP EP300

2.11e-06251235502657
Pubmed

Rubinstein-Taybi syndrome in a Saudi boy with distinct features and variants in both the CREBBP and EP300 genes: a case report.

CREBBP EP300

2.11e-06251230635043
Pubmed

p300 and cAMP response element-binding protein-binding protein in skeletal muscle homeostasis, contractile function, and survival.

CREBBP EP300

2.11e-06251231898871
Pubmed

Phenotype and genotype in 52 patients with Rubinstein-Taybi syndrome caused by EP300 mutations.

CREBBP EP300

2.11e-06251227648933
Pubmed

Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity.

CREBBP EP300

2.11e-06251230888860
Pubmed

Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.

CREBBP EP300

2.11e-06251227881443
Pubmed

Spatiotemporal expression of histone acetyltransferases, p300 and CBP, in developing embryonic hearts.

CREBBP EP300

2.11e-06251219272189
Pubmed

Developmentally regulated expression of the transcriptional cofactors/histone acetyltransferases CBP and p300 during mouse embryogenesis.

CREBBP EP300

2.11e-06251210610021
Pubmed

Emerging roles of p300/CBP in autophagy and autophagy-related human disorders.

CREBBP EP300

2.11e-06251237314181
Pubmed

Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal.

CREBBP EP300

2.11e-06251212397173
Pubmed

CBP/p300 TAZ1 domain forms a structured scaffold for ligand binding.

CREBBP EP300

2.11e-06251215641773
Pubmed

The double face of the histone variant H3.3.

H3Y2 H3Y1

2.11e-06251221263457
Pubmed

Differential contribution of p300 and CBP to regulatory element acetylation in mESCs.

CREBBP EP300

2.11e-06251232690000
Pubmed

Interaction of human immunodeficiency virus type 1 Tat with the transcriptional coactivators p300 and CREB binding protein.

CREBBP EP300

2.11e-0625129733868
Pubmed

CBP/p300 antagonises EGFR-Ras-Erk signalling and suppresses increased Ras-Erk signalling-induced tumour formation in mice.

CREBBP EP300

2.11e-06251230953353
Pubmed

Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control.

CREBBP EP300

2.11e-06251221803292
Pubmed

HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter.

CREBBP EP300

2.11e-0625129811832
Pubmed

Two independent regions of simian virus 40 T antigen increase CBP/p300 levels, alter patterns of cellular histone acetylation, and immortalize primary cells.

CREBBP EP300

2.11e-06251224089570
Pubmed

Rubinstein-Taybi syndrome in Chinese population with four novel mutations.

CREBBP EP300

2.11e-06251233063428
Pubmed

EP300/CBP is crucial for cAMP-PKA pathway to alleviate podocyte dedifferentiation via targeting Notch3 signaling.

CREBBP EP300

2.11e-06251234506759
Pubmed

Lack of somatic mutations in the catalytic domains of CREBBP and EP300 genes implies a role for histone deacetylase inhibition in myeloproliferative neoplasms.

CREBBP EP300

2.11e-06251222177454
Pubmed

Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease.

CREBBP EP300

2.11e-06251215706485
Pubmed

AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer.

CREBBP EP300

2.11e-06251239266679
Pubmed

A boy with classical Rubinstein-Taybi syndrome but no detectable mutation in the CREBBP and EP300 genes.

CREBBP EP300

2.11e-06251222303793
Pubmed

Neuregulin 1 mitigated prolactin deficiency through enhancing TRPM8 signaling under the influence of melatonin in senescent pituitary lactotrophs.

NRG1 TRPM8

2.11e-06251238969045
Pubmed

Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function.

CREBBP EP300

2.11e-06251234732714
Pubmed

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition.

CREBBP EP300

2.11e-06251234019788
Pubmed

Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y.

H3Y2 H3Y1

2.11e-06251220819935
Pubmed

Dendrite development regulated by CREST, a calcium-regulated transcriptional activator.

CREBBP EP300

6.32e-06351214716005
Pubmed

The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB.

CREBBP EP300

6.32e-06351218070920
Pubmed

The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression.

CREBBP EP300

6.32e-06351221967847
Pubmed

CBP and p300 are essential for renin cell identity and morphological integrity of the kidney.

CREBBP EP300

6.32e-06351219252086
Pubmed

Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP.

CREBBP EP300

6.32e-06351227903646
Pubmed

Inhibition of p300/CBP by early B-cell factor.

CREBBP EP300

6.32e-06351212748286
Pubmed

MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells.

NRG1 WWTR1

6.32e-06351226885614
Pubmed

p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively.

CREBBP EP300

6.32e-06351210075656
Pubmed

Genetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repression.

CREBBP EP300

6.32e-06351224340053
Pubmed

Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response.

CREBBP EP300

6.32e-06351219273602
Pubmed

Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation.

CREBBP EP300

6.32e-06351215649887
Pubmed

Expression patterns of histone acetyltransferases p300 and CBP during murine tooth development.

CREBBP EP300

6.32e-06351222179676
Pubmed

CBP/p300 are bimodal regulators of Wnt signaling.

CREBBP EP300

6.32e-06351217410209
Pubmed

DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes.

CREBBP EP300

6.32e-06351226951377
Pubmed

A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated.

PTK2 MAPK8IP3

6.32e-06351212226752
Pubmed

Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation.

KCNQ5 KCNQ2

6.32e-06351212890507
Pubmed

CBP/p300 and SIRT1 are involved in transcriptional regulation of S-phase specific histone genes.

CREBBP EP300

6.32e-06351221789216
Pubmed

Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex.

CREBBP EP300

6.32e-06351212050117
Pubmed

Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression.

CREBBP EP300

6.32e-06351216237459
Pubmed

A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis.

CREBBP EP300

6.32e-06351212384703
Pubmed

Regulation of transcription factor C/ATF by the cAMP signal activation in hippocampal neurons, and molecular interaction of C/ATF with signal integrator CBP/p300.

CREBBP EP300

6.32e-06351210350644
Pubmed

Loss of p300 and CBP disrupts histone acetylation at the mouse Sry promoter and causes XY gonadal sex reversal.

CREBBP EP300

6.32e-06351229145650
Pubmed

Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP.

CREBBP EP300

6.32e-0635127870179
Pubmed

The IFNgamma-induced STAT1-CBP/P300 association, required for a normal response to the cytokine, is disrupted in Brucella-infected macrophages.

CREBBP EP300

6.32e-06351219041714
Pubmed

JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration.

PTK2 MAPK8IP3

6.32e-06351216141199
Pubmed

Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP.

CREBBP EP300

6.32e-06351212776737
Pubmed

Convergence of Canonical and Non-Canonical Wnt Signal: Differential Kat3 Coactivator Usage.

CREBBP EP300

6.32e-06351230836930
Pubmed

Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.

CREBBP EP300

6.32e-06351214759370
Pubmed

Activation of Smad1-mediated transcription by p300/CBP.

CREBBP EP300

6.32e-06351210673036
Pubmed

Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.

CREBBP EP300

6.32e-06351212456660
Pubmed

Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment.

CREBBP EP300

6.32e-06351222474372
InteractionLATS2 interactions

TANC2 PALS1 PTPN13 OXA1L IQCB1 IQSEC1 AFDN WWTR1

4.40e-07289498int:LATS2
InteractionCALM3 interactions

PALS1 KCNQ5 HECW2 IQCB1 PLEKHA4 ASPM KCNQ2 ITPRID2

1.59e-06343498int:CALM3
InteractionCDC16 interactions

HECW2 IQCB1 PLEKHA4 ASPM WWTR1 CREBBP EP300

2.06e-06246497int:CDC16
InteractionCDH5 interactions

KIDINS220 KCNJ8 IQCB1 ASPM PTK2

6.66e-06109495int:CDH5
InteractionPTPN13 interactions

TANC2 PTPN13 IQCB1 PLEKHA4 AFDN WWTR1

9.19e-06202496int:PTPN13
InteractionSRCAP interactions

HECW2 PLEKHA4 WWTR1 CREBBP EP300

1.40e-05127495int:SRCAP
InteractionARID1A interactions

PLEKHA4 WWTR1 MSL1 CREBBP EP300 MAPK8IP3

5.33e-05276496int:ARID1A
InteractionPPP1R13L interactions

TANC2 PLEKHA4 CREBBP EP300

6.19e-0588494int:PPP1R13L
InteractionPTPN14 interactions

PTPN13 HECW2 PLEKHA4 AFDN WWTR1

6.89e-05177495int:PTPN14
InteractionPKN2 interactions

PTPN13 HECW2 PLEKHA4 WWTR1 EP300

8.06e-05183495int:PKN2
InteractionAMOTL1 interactions

PALS1 HECW2 AFDN WWTR1

8.34e-0595494int:AMOTL1
InteractionRIC8A interactions

IQCB1 PLEKHA4 EP300 MAPK8IP3

8.69e-0596494int:RIC8A
InteractionGAK interactions

PALS1 KIDINS220 PLEKHA4 WWTR1 CREBBP

9.39e-05189495int:GAK
InteractionKMT2A interactions

HECW2 SENP3 PLEKHA4 AFDN WWTR1 CREBBP

1.09e-04314496int:KMT2A
InteractionLIN7B interactions

PALS1 PLEKHA4 APBA1

1.35e-0441493int:LIN7B
InteractionAFDN interactions

PTPN13 KIDINS220 SENP3 GNL2 AFDN WWTR1

1.50e-04333496int:AFDN
InteractionKCNB1 interactions

KCNQ2 KCNG3 PTK2

1.56e-0443493int:KCNB1
InteractionARL15 interactions

PTPN13 PLEKHA4 APBA1 AFDN

1.63e-04113494int:ARL15
InteractionSTAT1 interactions

PLEKHA4 WWTR1 CREBBP EP300 PTK2 IFNA14

1.73e-04342496int:STAT1
InteractionNAP1L1 interactions

IQCB1 PLEKHA4 ASPM WWTR1 CREBBP EP300

1.81e-04345496int:NAP1L1
InteractionMTDH interactions

KCNQ5 PLEKHA4 GNL2 RNF213 CREBBP EXOSC2 EP300

2.05e-04505497int:MTDH
InteractionHOXB3 interactions

CREBBP EP300

2.06e-049492int:HOXB3
InteractionKCNV1 interactions

KCNQ2 KCNG3

2.06e-049492int:KCNV1
InteractionARGFX interactions

CREBBP EP300

2.06e-049492int:ARGFX
InteractionCD79B interactions

COLEC12 KIDINS220 SLC25A30 PTK2

2.19e-04122494int:CD79B
InteractionCRKL interactions

KIDINS220 PLEKHA4 WWTR1 MSL1 PTK2

2.21e-04227495int:CRKL
InteractionTRIP6 interactions

PTPN13 PLEKHA4 RNF213 WWTR1 MAPKBP1 PTK2

2.21e-04358496int:TRIP6
InteractionHBP1 interactions

SENP3 GNL2 CREBBP EP300

2.26e-04123494int:HBP1
InteractionLIMD1 interactions

TANC2 PLEKHA4 APBA1 WWTR1

2.34e-04124494int:LIMD1
InteractionTRIM4 interactions

PLEKHA4 TRPM8 WWTR1

2.44e-0450493int:TRIM4
InteractionNUMB interactions

PALS1 PLEKHA4 GNL2 AFDN WWTR1

2.44e-04232495int:NUMB
InteractionPPP1CA interactions

TANC2 KANK1 PLEKHA4 ASPM WWTR1 CREBBP EP300 PTK2

2.50e-04696498int:PPP1CA
InteractionCDC20 interactions

HECW2 PLEKHA4 APBA1 CREBBP EP300

2.54e-04234495int:CDC20
InteractionPARP1 interactions

PTPN13 KIDINS220 FLYWCH1 SENP3 PLEKHA4 GNL2 MSL1 ITPRID2 CREBBP EP300 PTK2

2.57e-0413164911int:PARP1
InteractionZC3H12C interactions

IQCB1 IQSEC1

2.57e-0410492int:ZC3H12C
InteractionEID1 interactions

ASPM CREBBP EP300

2.59e-0451493int:EID1
InteractionYWHAZ interactions

TANC2 NRG1 KANK1 PTPN13 ROGDI KCNQ5 PLEKHA4 AFDN WWTR1 ITPRID2 EP300

2.62e-0413194911int:YWHAZ
InteractionSPATS2L interactions

SENP3 GNL2 PTK2 IFNA14

2.64e-04128494int:SPATS2L
InteractionYWHAH interactions

TANC2 KANK1 PTPN13 KCNQ5 IQCB1 PLEKHA4 AFDN WWTR1 ITPRID2 CREBBP

2.68e-0411024910int:YWHAH
InteractionTP53BP2 interactions

PLEKHA4 AFDN WWTR1 CREBBP EP300

2.91e-04241495int:TP53BP2
InteractionGPHN interactions

SENP3 PLEKHA4 WWTR1 EP300

3.14e-04134494int:GPHN
InteractionEIF4E2 interactions

TANC2 PTPN13 PLEKHA4 AFDN EXOSC2

3.20e-04246495int:EIF4E2
InteractionKPNB1 interactions

SENP3 IQCB1 PLEKHA4 WWTR1 MSL1 EXOSC2 EP300

3.23e-04544497int:KPNB1
InteractionRBM27 interactions

PLEKHA4 GNL2 WWTR1 EP300

3.42e-04137494int:RBM27
InteractionDUS3L interactions

HECW2 PLEKHA4 EP300

3.42e-0456493int:DUS3L
InteractionSH3RF3 interactions

TANC2 PTPN13 MAPK8IP3

3.42e-0456493int:SH3RF3
InteractionUBE2S interactions

PLEKHA4 RNF213 CREBBP EP300

3.51e-04138494int:UBE2S
InteractionANAPC5 interactions

HECW2 PLEKHA4 CREBBP EP300

3.51e-04138494int:ANAPC5
InteractionMAP4K4 interactions

TANC2 PLEKHA4 AFDN WWTR1 PTK2

3.71e-04254495int:MAP4K4
InteractionEFNB1 interactions

PTPN13 IQCB1 MAP7D2 RNF213 AFDN

3.78e-04255495int:EFNB1
InteractionSLC30A4 interactions

COLEC12 IER3IP1 GNB4

3.79e-0458493int:SLC30A4
InteractionRPS6KA5 interactions

PLEKHA4 CREBBP EXOSC2 EP300

4.13e-04144494int:RPS6KA5
InteractionABCC9 interactions

KCNJ8 EP300

4.44e-0413492int:ABCC9
InteractionSCRIB interactions

PLEKHA4 RNF213 AFDN WWTR1 EP300

4.58e-04266495int:SCRIB
InteractionCEBPD interactions

RNF213 CREBBP EP300

4.62e-0462493int:CEBPD
InteractionHOXA10 interactions

WWTR1 CREBBP EP300

4.62e-0462493int:HOXA10
InteractionMDC1 interactions

FLYWCH1 PLEKHA4 MSL1 CREBBP EXOSC2 EP300

4.80e-04414496int:MDC1
InteractionMAPK10 interactions

MAPKBP1 CREBBP MAPK8IP3

4.84e-0463493int:MAPK10
InteractionCCNA1 interactions

HECW2 EP300 PTK2

4.84e-0463493int:CCNA1
InteractionCGN interactions

TANC2 PTPN13 AFDN WWTR1

5.06e-04152494int:CGN
InteractionWWTR1 interactions

PALS1 PTPN13 AFDN WWTR1 CREBBP EP300

5.31e-04422496int:WWTR1
InteractionABT1 interactions

SENP3 PLEKHA4 GNL2 WWTR1 THAP3 EP300

5.38e-04423496int:ABT1
InteractionNUP35 interactions

PRPF40B PLEKHA4 AFDN WWTR1 CREBBP EP300

5.45e-04424496int:NUP35
InteractionKCNB2 interactions

KCNQ2 AFDN KCNG3

5.55e-0466493int:KCNB2
InteractionSLTM interactions

SENP3 PLEKHA4 EP300 IFNA14

5.58e-04156494int:SLTM
InteractionCDC25C interactions

TANC2 PTPN13 PLEKHA4 EP300

5.58e-04156494int:CDC25C
CytobandEnsembl 112 genes in cytogenetic band chr16p13

ROGDI FLYWCH1 NPIPA2 CREBBP MAPK8IP3

1.11e-04426515chr16p13
Cytoband16p13.3

ROGDI FLYWCH1 CREBBP MAPK8IP3

1.60e-0424451416p13.3
Cytoband5p15.1

H3Y2 H3Y1

6.25e-04335125p15.1
GeneFamilyPDZ domain containing

PALS1 PTPN13 APBA1 AFDN PDZRN4

7.72e-061523351220
GeneFamilyPotassium voltage-gated channels

KCNQ5 KCNQ2 KCNG3

5.23e-0540333274
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

CREBBP EP300

4.32e-0417332486
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

CREBBP EP300

4.85e-041833291
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

ATRN COLEC12

2.53e-03413321298
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

PTPN13 PTK2

3.75e-03503321293
GeneFamilyAnkyrin repeat domain containing

TANC2 KANK1 KIDINS220

9.61e-03242333403
CoexpressionCUI_TCF21_TARGETS_2_DN

COLEC12 PALS1 KANK1 HECW2 IQSEC1 WWTR1 ITPRID2 CREBBP EP300

2.13e-05854489M1533
CoexpressionCUI_TCF21_TARGETS_2_DN

COLEC12 PALS1 KANK1 HECW2 IQSEC1 WWTR1 ITPRID2 CREBBP EP300

2.89e-05888489MM1018
ToppCellLPS_IL1RA-Endothelial-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

KIDINS220 RNF213 AFDN ITPRID2 PTK2

3.28e-0620051572ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCellLPS_IL1RA-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

KIDINS220 RNF213 AFDN ITPRID2 PTK2

3.28e-062005155c092b2ecc081b5d04476c56333c338cd89ab984
ToppCellLPS-IL1RA-Stromal_mesenchymal-Fibroblasts-Pericyte_2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NRG1 PLEKHA4 GNL2 MAP7D2

3.22e-051585147f5426585d0d299d2b48e5fcb349950feffdef33
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KCNQ5 KCNJ8 ASPM MAP7D2

4.79e-05175514fa16c6ba08dc0cc22e8cf049db0577811d080df6
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TANC2 NRG1 APBA1 LRP3

5.12e-0517851430ca37f70d267cc9b40ca3e211f16d30360c3e6b
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PALS1 KANK1 PTPN13 APBA1

5.70e-051835143c516fe5083f02bad1f464ed284010b4131a833c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PALS1 KANK1 PTPN13 APBA1

5.70e-051835149c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PALS1 KANK1 PTPN13 APBA1

5.82e-051845147294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

TANC2 COLEC12 KANK1 PTPN13

6.33e-05188514ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCellfacs-Skin|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KANK1 AFDN ITPRID2 PDZRN4

6.73e-05191514ae524103331fa53fa82888dbb567fc36abcee7e0
ToppCellLPS-antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HECW2 AFDN WWTR1 PTK2

7.01e-051935146e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HECW2 AFDN WWTR1 PTK2

7.15e-051945140b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

TANC2 KANK1 PTPN13 WWTR1

7.15e-0519451497534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_B-Plasma_cell-B_c06-MKI67|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KCNQ5 DTX1 ASPM NPIPA2

7.15e-051945145771a28a61f4d9b5479891f3224909ab003cb241
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KCNQ5 KCNJ8 GNB4 PDZRN4

7.44e-05196514acbb493dbb49a33f20cf11106363f7ed51209706
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

TANC2 KANK1 PTPN13 PTK2

7.73e-051985141996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TANC2 COLEC12 KANK1 PTPN13

7.73e-051985142e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCellfacs-Trachea-nan-3m-Mesenchymal-chondrocyte|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COLEC12 KANK1 IQSEC1 PDZRN4

7.73e-0519851471e847e8c24744d6df4a960348ad2ecf310373b4
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TANC2 COLEC12 KANK1 PTPN13

7.73e-05198514f948391296c261c473d339069a6d0f20ccd6f38f
ToppCellTransverse-Macrophage-LYVE1_Macrophage|Macrophage / Region, Cell class and subclass

COLEC12 SENP3 LRP3 C1QTNF4

7.89e-05199514fd75dccb37d96448edf72b7d042b06833d4ead24
ToppCellTransverse-(2)_B_cell-(24)_B_cell_cycling|Transverse / shred on region, Cell_type, and subtype

DTX1 ASPM WWTR1 PTK2

8.04e-05200514e3f9736227151f23f0e331eec0a7a15ce464b517
ToppCellTransverse-B_cell-B_cell_cycling|Transverse / Region, Cell class and subclass

DTX1 ASPM WWTR1 PTK2

8.04e-052005140e270f8019d9f22068ca426d661937262a5cd331
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

KIDINS220 RNF213 AFDN PTK2

8.04e-0520051479e51afb57ca38aacebd0298e5e727b55c0cfff9
ComputationalNeighborhood of MAP4K4

TANC2 ATRN KIDINS220 PTK2 MAPK8IP3

1.40e-04172325GCM_MAP4K4
DiseaseMenke-Hennekam syndrome

CREBBP EP300

2.70e-062492cv:C5681632
DiseaseRubinstein-Taybi syndrome (implicated_via_orthology)

CREBBP EP300

2.70e-062492DOID:1933 (implicated_via_orthology)
DiseaseRubinstein-Taybi syndrome

CREBBP EP300

2.70e-062492cv:C0035934
DiseaseRUBINSTEIN-TAYBI SYNDROME 1

CREBBP EP300

2.70e-062492C4551859
DiseaseRUBINSTEIN-TAYBI SYNDROME 1

CREBBP EP300

2.70e-062492180849
DiseaseRubinstein-Taybi syndrome due to CREBBP mutations

CREBBP EP300

2.70e-062492cv:C4551859
DiseaseRubinstein-Taybi syndrome (is_implicated_in)

CREBBP EP300

2.70e-062492DOID:1933 (is_implicated_in)
DiseaseRubinstein-Taybi Syndrome

CREBBP EP300

2.70e-062492C0035934
Diseaseangiotensin-converting enzyme measurement

TANC2 NRG1

9.65e-059492EFO_0006515
DiseaseSclerocystic Ovaries

NRG1 ASPM THAP3 MAPK8IP3

9.72e-05144494C1136382
DiseasePolycystic Ovary Syndrome

NRG1 ASPM THAP3 MAPK8IP3

9.72e-05144494C0032460
Diseaselong QT syndrome (implicated_via_orthology)

KCNQ5 KCNQ2

1.21e-0410492DOID:2843 (implicated_via_orthology)
Diseasedevelopmental and epileptic encephalopathy (implicated_via_orthology)

KCNQ5 KCNQ2

2.08e-0413492DOID:0112202 (implicated_via_orthology)
DiseaseAdenoid Cystic Carcinoma

ASPM CREBBP EP300

6.21e-04100493C0010606
DiseaseIntellectual Disability

TANC2 KCNQ5 IER3IP1 IQSEC1 MAPK8IP3

8.60e-04447495C3714756
DiseaseSquamous cell carcinoma

CREBBP EP300 PTK2

1.16e-03124493C0007137
Diseaseheart conduction disease (implicated_via_orthology)

KCNQ5 KCNQ2

1.30e-0332492DOID:10273 (implicated_via_orthology)
Diseasemicrocephaly (implicated_via_orthology)

ASPM MAPKBP1

1.30e-0332492DOID:10907 (implicated_via_orthology)
Diseaselung squamous cell carcinoma (is_marker_for)

PTPN13 PTK2

1.64e-0336492DOID:3907 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
MLIMQRLEAERRARL

AFDN

1591

P55196
RLQQAQMLRRRMASM

EP300

1821

Q09472
LMRNRNRKVSRMRCL

ACRBP

496

Q8NEB7
RRVTIMPRDMQLARR

H3Y2

116

P0DPK5
RREMQSQSVMLALRR

C1QTNF4

266

Q9BXJ3
QAQLMRRRMATMNTR

CREBBP

1861

Q92793
ATLIQRRFRTLMMRR

ASPM

2266

Q8IZT6
QRRRREFMMRSRLEC

PDZRN4

956

Q6ZMN7
QLMNLIRSVRTVMRV

IER3IP1

51

Q9Y5U9
DRLRQSLRSERNNMM

NRG1

276

Q02297
LQRAGVTLRVLRMMR

KCNG3

281

Q8TAE7
MEQLNRRYQSIRRTM

HECW2

856

Q9P2P5
SLNNRRTLMLMAQMR

IFNA14

31

P01570
RRQMQRTITRQMSFD

KIDINS220

906

Q9ULH0
NMRDRATIRRLNMYR

GNL2

31

Q13823
MRRNNSMRRNNSIRR

KCNJ8

386

Q15842
PMAQRRRFTRVEMAR

MAPK8IP3

516

Q9UPT6
RLEAMMRRSLERTQQ

MAP7D2

126

Q96T17
RAITQGRRVMVMRRH

FLYWCH1

551

Q4VC44
RRREQLLREMQQMAS

ATRN

1311

O75882
RLRSSMSENRMSRRI

IQSEC1

156

Q6DN90
LRSLRFLQILRMVRM

KCNQ5

231

Q9NR82
RRVTIMPRDMQLARR

H3Y1

116

P0DPK2
RFLQILRMIRMDRRG

KCNQ2

201

O43526
SVSLRMQQDLMRSRL

COLEC12

396

Q5KU26
TRRRLEQERATMQMT

KANK1

161

Q14678
ASVLQNLRTAMRRQM

LRP3

576

O75074
NMDSVGRIQMRTRRT

GNB4

36

Q9HAV0
NAEMTRQLREREQRM

OXA1L

371

Q15070
TLLARIERMERRMQL

MSL1

256

Q68DK7
MEMFQRAQALRRRAE

NPIPA2

201

E9PIF3
RLRNCIISLVTQRMM

EXOSC2

236

Q13868
LQVMRRSLNLFRTQM

ITPRID2

961

P28290
MSQMNRQTRRRRRLR

DTX1

156

Q86Y01
RMMPIRRSAQLERIR

PALS1

46

Q8N3R9
VDVVRTRMMNQRVLR

SLC25A30

221

Q5SVS4
TRMMNQRVLRDGRCS

SLC25A30

226

Q5SVS4
VLMARRRMPRSNSQE

APBA1

556

Q02410
MTISMRQRLAELRQR

MAPKBP1

736

O60336
RQRAMRLSRELQLSM

IQCB1

356

Q15051
MQRMLIVRSLRQDRV

DNAH2

3786

Q9P225
TMVSNRLRLALVRMQ

PTPN13

2331

Q12923
MDAVMLQLTRARNRL

ROGDI

146

Q9GZN7
RPRMSAQEQLERMRR

PLEKHA4

586

Q9H4M7
QQEERMRMESRRQAT

PTK2

686

Q05397
EMRRRQEEAMRRLAS

TANC2

436

Q9HCD6
TCSQRRRRAMRAFRM

SENP3

121

Q9H4L4
MLRDQNESCTRNMRR

RNF213

3546

Q63HN8
MRRREAAFRSMLRQA

PRPF40B

626

Q6NWY9
LQAQRLVMRRMSSRL

THAP3

206

Q8WTV1
MSFRAARLSMRNRRN

TRPM8

1

Q7Z2W7
RLQRIQMERERIRMR

WWTR1

236

Q9GZV5