Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

CDK20 STK3 PHKA1 ATR TBK1 HUNK WNK4 AURKB STK25

1.07e-04446849GO:0004674
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

CDK20 STK3 PHKA1 ATR POLE TBK1 PANK4 CRPPA TNKS HUNK WNK4 AURKB STK25

1.41e-049388413GO:0016772
GeneOntologyMolecularFunctionprotein serine kinase activity

CDK20 STK3 ATR TBK1 HUNK WNK4 AURKB STK25

1.45e-04363848GO:0106310
GeneOntologyMolecularFunctioncomplement component C1q complex binding

C4A C4B

7.70e-0410842GO:0001849
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

CDK20 STK3 PHKA1 ATR TBK1 PANK4 HUNK WNK4 AURKB STK25

7.72e-047098410GO:0016773
GeneOntologyMolecularFunctiontransition metal ion transmembrane transporter activity

ATP7A SLC39A3 SLC39A7

8.40e-0444843GO:0046915
GeneOntologyMolecularFunctionprotein kinase activity

CDK20 STK3 PHKA1 ATR TBK1 HUNK WNK4 AURKB STK25

9.33e-04600849GO:0004672
GeneOntologyMolecularFunctionendopeptidase inhibitor activity

SERPINB4 SERPINB12 SERPINB1 C4A C4B

9.78e-04180845GO:0004866
GeneOntologyBiologicalProcesspositive regulation of telomere maintenance via telomerase

ATR CCT8 TNKS AURKB

1.30e-0536834GO:0032212
GeneOntologyBiologicalProcesspositive regulation of telomere maintenance via telomere lengthening

ATR CCT8 TNKS AURKB

1.80e-0539834GO:1904358
DomainRMMBL

INTS11 CPSF3

5.84e-053832IPR011108
DomainRMMBL

INTS11 CPSF3

5.84e-053832PF07521
DomainBeta-Casp

INTS11 CPSF3

1.16e-044832PF10996
DomainBeta_Casp

INTS11 CPSF3

1.16e-044832IPR022712
DomainBeta-Casp

INTS11 CPSF3

1.16e-044832SM01027
DomainAnaphylatoxin_comp_syst

C4A C4B

1.93e-045832IPR018081
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

1.93e-045832IPR001840
DomainSerpin_CS

SERPINB4 SERPINB12 SERPINB1

3.82e-0432833IPR023795
DomainANATO

C4A C4B

4.04e-047832SM00104
DomainANATO

C4A C4B

4.04e-047832PF01821
DomainANAPHYLATOXIN_2

C4A C4B

4.04e-047832PS01178
DomainANAPHYLATOXIN_1

C4A C4B

4.04e-047832PS01177
DomainAnaphylatoxin/fibulin

C4A C4B

4.04e-047832IPR000020
DomainThiol-ester_cl

C4A C4B

5.37e-048832PF10569
DomainMacrogloblnA2_thiol-ester-bond

C4A C4B

5.37e-048832IPR019565
DomainMacrogloblnA2_CS

C4A C4B

5.37e-048832IPR019742
DomainSerpin_dom

SERPINB4 SERPINB12 SERPINB1

5.44e-0436833IPR023796
DomainSERPIN

SERPINB4 SERPINB12 SERPINB1

5.90e-0437833SM00093
DomainSERPIN

SERPINB4 SERPINB12 SERPINB1

5.90e-0437833PS00284
DomainSerpin

SERPINB4 SERPINB12 SERPINB1

6.38e-0438833PF00079
DomainSerpin_fam

SERPINB4 SERPINB12 SERPINB1

6.89e-0439833IPR000215
DomainA2M_N

C4A C4B

8.58e-0410832PF01835
DomainA2M_N

C4A C4B

8.58e-0410832IPR002890
DomainA-macroglobulin_rcpt-bd

C4A C4B

8.58e-0410832IPR009048
DomainALPHA_2_MACROGLOBULIN

C4A C4B

8.58e-0410832PS00477
DomainA2M

C4A C4B

8.58e-0410832PF00207
DomainA2M_N_2

C4A C4B

8.58e-0410832IPR011625
DomainA2M_comp

C4A C4B

8.58e-0410832IPR011626
DomainA2M_N_2

C4A C4B

8.58e-0410832PF07703
DomainA2M_recep

C4A C4B

8.58e-0410832PF07677
DomainA2M_comp

C4A C4B

8.58e-0410832PF07678
DomainMacroglobln_a2

C4A C4B

8.58e-0410832IPR001599
DomainSer/Thr_kinase_AS

CDK20 STK3 TBK1 HUNK WNK4 AURKB STK25

1.05e-03357837IPR008271
DomainS_TKc

CDK20 STK3 TBK1 HUNK WNK4 AURKB STK25

1.09e-03359837SM00220
DomainPROTEIN_KINASE_ST

CDK20 STK3 TBK1 HUNK WNK4 AURKB STK25

1.14e-03362837PS00108
DomainLactamase_B

INTS11 CPSF3

1.47e-0313832PF00753
DomainPkinase

CDK20 STK3 TBK1 HUNK WNK4 AURKB STK25

1.53e-03381837PF00069
DomainDynein_heavy_chain_D4_dom

DNAH8 DNAH1

1.72e-0314832IPR024317
DomainDynein_HC_stalk

DNAH8 DNAH1

1.72e-0314832IPR024743
DomainZip

SLC39A3 SLC39A7

1.72e-0314832PF02535
DomainDynein_heavy_dom-2

DNAH8 DNAH1

1.72e-0314832IPR013602
DomainDHC_N2

DNAH8 DNAH1

1.72e-0314832PF08393
DomainMT

DNAH8 DNAH1

1.72e-0314832PF12777
DomainAAA_8

DNAH8 DNAH1

1.72e-0314832PF12780
DomainATPase_dyneun-rel_AAA

DNAH8 DNAH1

1.72e-0314832IPR011704
DomainZIP

SLC39A3 SLC39A7

1.72e-0314832IPR003689
DomainAAA_5

DNAH8 DNAH1

1.72e-0314832PF07728
DomainDHC_fam

DNAH8 DNAH1

1.97e-0315832IPR026983
DomainLactamase_B

INTS11 CPSF3

1.97e-0315832SM00849
DomainDynein_heavy_dom

DNAH8 DNAH1

1.97e-0315832IPR004273
DomainDynein_heavy

DNAH8 DNAH1

1.97e-0315832PF03028
DomainC345C

C4A C4B

2.54e-0317832SM00643
DomainKinase-like_dom

CDK20 STK3 ATR TBK1 HUNK WNK4 AURKB STK25

2.80e-03542838IPR011009
DomainTerpenoid_cyclase/PrenylTrfase

C4A C4B

2.85e-0318832IPR008930
DomainNTR

C4A C4B

3.18e-0319832PF01759
DomainNetrin_module_non-TIMP

C4A C4B

3.18e-0319832IPR018933
Domain-

INTS11 CPSF3

3.52e-03208323.60.15.10
DomainMetallo-B-lactamas

INTS11 CPSF3

3.52e-0320832IPR001279
DomainPROTEIN_KINASE_ATP

CDK20 STK3 TBK1 HUNK WNK4 AURKB STK25

4.31e-03459837PS00107
PathwayREACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM

FASN PANK4 PPCDC

4.48e-0515673MM14782
PathwayREACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM

FASN PANK4 PPCDC

1.10e-0420673M538
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

STK3 TFB1M POLE TBK1 UGGT1 PANK4 HIP1R ANKRD28 TUBGCP5 DIS3 AURKB STK25

2.54e-08606841236538041
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

FASN ERCC6 TFB1M SERPINB4 SERPINB12 POLE SHCBP1 RPP30 INTS11 HIP1R CCT8 GEMIN5 ANKRD28 DHX33 CPSF3 DIS3

1.33e-071353841629467282
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

TACO1 FASN POLE RPP30 INTS11 CCT8 EIF3C DHX33 DNAH8 MRPL11 AURKB

1.05e-06704841129955894
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

RAPGEF6 ATR POLE TBK1 SHCBP1 ANKRD28 C4A C4B ZBTB11 DIS3

3.87e-06650841038777146
Pubmed

Transcription-coupled nucleotide excision repair is coordinated by ubiquitin and SUMO in response to ultraviolet irradiation.

TACO1 ERCC6 EIF3C MRPL11 SLC39A7

5.05e-0610284531722399
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

SERPINB4 TBK1 SHCBP1 APBA2 ANKRD28 TNKS EIF3C DHX33 USP48 DIS3 SLC39A7 STK25

5.30e-061005841219615732
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

5.76e-06284222737222
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

5.76e-06284216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

5.76e-06284215998580
Pubmed

Structural polymorphism of murine C4 and its linkage to H-2.

C4A C4B

5.76e-0628427373044
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

5.76e-06284219062096
Pubmed

The chemical structure of the C4d fragment of the human complement component C4.

C4A C4B

5.76e-0628423696167
Pubmed

P2X7 Receptor Expression and Signaling on Dendritic Cells and CD4+ T Cells is Not Required but Can Enhance Th17 Differentiation.

ZBTB46 P2RX7

5.76e-06284235350380
Pubmed

Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.

C4A C4B

5.76e-0628421357031
Pubmed

Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.

C4A C4B

5.76e-06284216098595
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

5.76e-06284219933335
Pubmed

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

C4A C4B

5.76e-0628422459207
Pubmed

Antigen-induced B cell apoptosis is independent of complement C4.

C4A C4B

5.76e-06284217645767
Pubmed

Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.

C4A C4B

5.76e-06284215787745
Pubmed

Anti-DNA autoreactivity in C4-deficient mice.

C4A C4B

5.76e-06284212207352
Pubmed

Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.

C4A C4B

5.76e-06284230026462
Pubmed

A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.

C4A C4B

5.76e-0628426559257
Pubmed

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

C4A C4B

5.76e-06284227758680
Pubmed

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

C4A C4B

5.76e-06284222387014
Pubmed

Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.

C4A C4B

5.76e-06284234299197
Pubmed

Assessment of complement C4 gene copy number using the paralog ratio test.

C4A C4B

5.76e-06284220506482
Pubmed

Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.

C4A C4B

5.76e-06284212480675
Pubmed

Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.

C4A C4B

5.76e-06284226800705
Pubmed

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.

C4A C4B

5.76e-06284223749435
Pubmed

Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.

C4A C4B

5.76e-06284223918728
Pubmed

Murine complement C4 is not required for experimental autoimmune encephalomyelitis.

C4A C4B

5.76e-06284215390104
Pubmed

Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.

C4A C4B

5.76e-0628423037333
Pubmed

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

C4A C4B

5.76e-06284211726230
Pubmed

Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

C4A C4B

5.76e-0628424216347
Pubmed

Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.

C4A C4B

5.76e-0628421699796
Pubmed

Sequence determination of the thiolester site of the fourth component of human complement.

C4A C4B

5.76e-0628426950384
Pubmed

Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.

C4A C4B

5.76e-0628422997024
Pubmed

Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.

C4A C4B

5.76e-0628428660986
Pubmed

Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.

C4A C4B

5.76e-0628423624865
Pubmed

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

C4A C4B

5.76e-0628428428773
Pubmed

Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.

C4A C4B

5.76e-06284221857912
Pubmed

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.

C4A C4B

5.76e-06284224638111
Pubmed

Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.

C4A C4B

5.76e-0628426208559
Pubmed

The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.

C4A C4B

5.76e-0628424514997
Pubmed

Transcriptional repression of C4 complement by hepatitis C virus proteins.

C4A C4B

5.76e-06284221345967
Pubmed

The inheritance of susceptibility to the Gross leukemia virus in mice.

C4A C4B

5.76e-0628425919331
Pubmed

An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.

C4A C4B

5.76e-0628423167981
Pubmed

The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.

C4A C4B

5.76e-0628427545960
Pubmed

Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.

C4A C4B

5.76e-06284230041577
Pubmed

Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

C4A C4B

5.76e-0628422572548
Pubmed

The complement component C4 of mammals.

C4A C4B

5.76e-0628422302180
Pubmed

Complete cDNA sequence of the fourth component of murine complement.

C4A C4B

5.76e-0628423862104
Pubmed

The BS variant of C4 protects against age-related loss of white matter microstructural integrity.

C4A C4B

5.76e-06284234358307
Pubmed

Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.

C4A C4B

5.76e-06284218360261
Pubmed

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

C4A C4B

5.76e-06284222151770
Pubmed

C4d-positive chronic rejection: a frequent entity with a poor outcome.

C4A C4B

5.76e-06284218091514
Pubmed

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.

C4A C4B

5.76e-06284229080553
Pubmed

Schizophrenia risk from complex variation of complement component 4.

C4A C4B

5.76e-06284226814963
Pubmed

Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

C4A C4B

5.76e-0628426589636
Pubmed

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.

C4A C4B

5.76e-06284225339671
Pubmed

A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.

C4A C4B

5.76e-06284217728371
Pubmed

Structure and organization of the C4 genes.

C4A C4B

5.76e-0628426149580
Pubmed

Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.

C4A C4B

5.76e-0628426149581
Pubmed

The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.

C4A C4B

5.76e-06284212115608
Pubmed

Biochemistry and biology of anaphylatoxins.

C4A C4B

5.76e-0628423542363
Pubmed

C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.

C4A C4B

5.76e-0628422387317
Pubmed

Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.

C4A C4B

5.76e-0628428132550
Pubmed

Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.

C4A C4B

5.76e-0628422395880
Pubmed

Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.

C4A C4B

5.76e-06284226814708
Pubmed

cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).

C4A C4B

5.76e-0628426192448
Pubmed

Complete primary structure of human C4a anaphylatoxin.

C4A C4B

5.76e-0628426167582
Pubmed

Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.

C4A C4B

5.76e-06284216908004
Pubmed

Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.

C4A C4B

5.76e-0628421438267
Pubmed

Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.

C4A C4B

5.76e-0628427365238
Pubmed

Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.

C4A C4B

5.76e-06284219150565
Pubmed

Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.

C4A C4B

5.76e-0628427391573
Pubmed

Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.

C4A C4B

5.76e-06284217506029
Pubmed

Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.

C4A C4B

5.76e-06284217971360
Pubmed

Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.

C4A C4B

5.76e-06284223715124
Pubmed

Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.

C4A C4B

5.76e-0628423464002
Pubmed

Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.

C4A C4B

5.76e-0628422993295
Pubmed

Clinical features of patients with homozygous complement C4A or C4B deficiency.

C4A C4B

5.76e-06284229928053
Pubmed

Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.

C4A C4B

5.76e-06284217971229
Pubmed

Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.

C4A C4B

5.76e-0628426881182
Pubmed

Identification of the site of sulfation of the fourth component of human complement.

C4A C4B

5.76e-0628423944109
Pubmed

Partial C4 deficiency in juvenile idiopathic arthritis patients.

C4A C4B

5.76e-06284217921792
Pubmed

Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.

C4A C4B

5.76e-06284221880985
Pubmed

Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.

C4A C4B

5.76e-0628426978711
Pubmed

Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.

C4A C4B

5.76e-06284235898513
Pubmed

Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.

C4A C4B

5.76e-06284233353966
Pubmed

Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).

C4A C4B

5.76e-0628423008092
Pubmed

Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.

C4A C4B

5.76e-06284228873507
Pubmed

The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4.

C4A C4B

5.76e-0628426609966
Pubmed

Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes.

C4A C4B

5.76e-0628422900855
Pubmed

Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.

C4A C4B

5.76e-062842276882
Pubmed

Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.

C4A C4B

5.76e-0628426832377
Pubmed

An examination of the metal ion content in the active sites of human endonucleases CPSF73 and INTS11.

INTS11 CPSF3

5.76e-06284236822327
Pubmed

Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.

C4A C4B

5.76e-0628423794341
Pubmed

Complement and c4 null alleles in severe chronic adult periodontitis.

C4A C4B

5.76e-06284217257223
Pubmed

Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events.

C4A C4B

5.76e-0628422272665
InteractionCLEC16A interactions

STK3 TFB1M POLE TBK1 UGGT1 PANK4 HIP1R ANKRD28 TUBGCP5 DIS3 AURKB STK25

1.12e-056298412int:CLEC16A
InteractionTAX1BP1 interactions

GDA FASN TBK1 CCT8 SERPINB1 MRPL11 CPSF3 AURKB STK25

1.26e-05342849int:TAX1BP1
Cytoband12q24

P2RX7 HPD HIP1R

1.32e-052584312q24
GeneFamilySerpin peptidase inhibitors

SERPINB4 SERPINB12 SERPINB1

1.72e-0437533739
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

C4A C4B

3.00e-0495321234
GeneFamilyDyneins, axonemal

DNAH8 DNAH1

1.11e-0317532536
GeneFamilyComplement system|Sushi domain containing

C4A C4B

4.98e-0336532492
GeneFamilyGlycosyltransferase family 6|Blood group antigens

C4A C4B

5.26e-0337532454
GeneFamilyBasic leucine zipper proteins|BTB domain containing

ZBTB46 ZBTB41 ZBTB11

7.12e-03134533861
GeneFamilyPDZ domain containing

RAPGEF6 GIPC2 APBA2

1.00e-021525331220
ToppCell3'-Child09-12-SmallIntestine-Mesenchymal-fibroblastic-Stromal_4_(MMP1+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZBTB46 STON1 IGFBP7 PCDHB11 TENM1 C4A

1.07e-06177846ac90e4ce5be304a5a7473736397327010f2d1999
ToppCellCOPD-Lymphoid-T|Lymphoid / Disease state, Lineage and Cell class

RAPGEF6 ANKRD28 CPD JAML FRMD4B FAAH2

1.94e-06196846c9bdd505c3ab380ed7b272aa518df31a0a706a06
ToppCellCOVID-19-lung-Macrophage_LDB2hi_OSMRhi_YAP1hi|lung / Disease (COVID-19 only), tissue and cell type

PIK3AP1 CPPED1 P2RX7 PLXDC2 C9orf72 JAML

2.00e-061978463896729740d151f0eb845f1961c7b969bfbdd28d
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

RAPGEF6 PANK4 TENM1 ZBTB11 JAML

6.88e-061408457b359bfbd404ab06d799048252f4985d85852048
ToppCellwk_15-18-Hematologic-Myeloid-Eosinophil|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CPPED1 SLC39A3 SERPINB1 ANKRD28 CRPPA

1.92e-05173845a85cead231e03945fabbc7762540ad21fe4299df
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SEPTIN3 SHCBP1 RPP30 PANK4 MRPL11

2.02e-05175845f7d191cde68de8f3457fa62b1df53b6d0dbe5001
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-DN3_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERCC6 ZBTB41 ZBTB11 DNAH8 FRMD4B

2.38e-05181845e2d03115a87f45a7ddd3ade6b9ac3843639bd41a
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERCC6 ZBTB41 ZBTB11 DNAH8 FRMD4B

2.38e-05181845d8d11ef83c4b8b6a6f5c8728e03059e45a8ad264
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHCBP1 TENM1 ANKRD28 C4A AURKB

2.44e-0518284539f9b3eb22293cc27c6e175702c77d1eeb24fdc9
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TACO1 KIF1A CCDC42 TRMT13 DNAH1

2.51e-05183845dc9602bed3136db91faeffef177006246dc92743
ToppCellwk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

TFB1M POLE TBK1 HIP1R COG8

2.64e-05185845636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCellCOVID-19-lung-Plasma_cells_PRDM1/BLIMP_hi|COVID-19 / Disease (COVID-19 only), tissue and cell type

SHCBP1 PPCDC ANKRD28 USP48 AURKB

2.85e-05188845567b08514d9d84cbb40f9b7a679eec304f023428
ToppCellControl-Myeloid-Monocytes|Control / group, cell type (main and fine annotations)

PIK3AP1 CPPED1 PLXDC2 C9orf72 JAML

2.93e-051898453335d16bd0ffa0c1ddd06d7da645299148130c3f
ToppCellCOPD-Lymphoid-T_Regulatory|Lymphoid / Disease state, Lineage and Cell class

RAPGEF6 USP48 DNAH8 FRMD4B FAAH2

3.08e-051918453ae18bc4e3dff49b5d5958da8ebc3f747274b69c
ToppCellAdult-Immune-monocyte-D175|Adult / Lineage, Cell type, age group and donor

PIK3AP1 CPPED1 P2RX7 PLXDC2 JAML

3.08e-05191845cbebb4d9550fdcd606cb3685ac9546c6b73fd422
ToppCellPBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

POLE SHCBP1 SERPINB1 ANKRD28 AURKB

3.23e-05193845ccab6a0c76f574ef7e1d6d5f1e620376daf21bbf
ToppCellPBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

POLE SHCBP1 SERPINB1 ANKRD28 AURKB

3.32e-0519484523318a1b55895b5166c6151f488a94a09b4627ff
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3AP1 P2RX7 PLXDC2 JAML FRMD4B

3.40e-0519584591a3c439f10c03c5d51d904f512b6a08040edc76
ToppCellAdult-Immune-monocyte-D231|Adult / Lineage, Cell type, age group and donor

PIK3AP1 CPPED1 PLXDC2 C9orf72 JAML

3.40e-05195845ea24da6fea1487acb1e56c28c0649858cc0a12bd
ToppCellControl-Lymphoid-T|Lymphoid / Disease state, Lineage and Cell class

RAPGEF6 ANKRD28 JAML FRMD4B FAAH2

3.40e-051958456687e579582d7a239bee80846de0cf827a6f6a62
ToppCelldistal-Epithelial-Proximal_Basal|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GDA SERPINB4 CLIC6 HUNK FAAH2

3.48e-05196845c102b28d5d1d90b9f7024cb51114276354be26a5
ToppCelldistal-Epithelial-Proximal_Basal-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GDA SERPINB4 CLIC6 HUNK FAAH2

3.48e-05196845a543d4623096cb3f9170dbf7af52381e77aa435e
ToppCellChildren_(3_yrs)-Immune-monocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

PIK3AP1 CPPED1 PLXDC2 C9orf72 JAML

3.48e-05196845cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCellIPF-Lymphoid-T|Lymphoid / Disease state, Lineage and Cell class

RAPGEF6 ANKRD28 JAML FRMD4B FAAH2

3.48e-051968456e70c48a63d9673eb16b0847c1bd88eecc2f7a3c
ToppCellFetal_29-31_weeks-Immune-monocyte|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PIK3AP1 CPPED1 P2RX7 C9orf72 JAML

3.57e-0519784548a8169a4d33c6a68d66bcd936861c75cb4b60ef
ToppCellCOVID-19-lung-Macrophage_LDB2hi_OSMRhi_YAP1hi|COVID-19 / Disease (COVID-19 only), tissue and cell type

PIK3AP1 P2RX7 PLXDC2 C9orf72 JAML

3.57e-05197845e42910a653a1b5bd90c090e9665a84871ed2873f
ToppCellCOVID-19-lung-Macrophage_VCANhi_FCN1hi|lung / Disease (COVID-19 only), tissue and cell type

PIK3AP1 CPPED1 P2RX7 PLXDC2 JAML

3.57e-05197845a0f8a992282a6d64890f5574c7c9741fcb38dadd
ToppCellsystemic_lupus_erythematosus-treated-Myeloid-classical_monocyte-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

CPPED1 PLXDC2 SERPINB1 C9orf72 JAML

3.65e-05198845c79c1738560d78b63dbed5f2f9621dbc1c2363cb
ToppCellsystemic_lupus_erythematosus-treated-Myeloid-classical_monocyte|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

CPPED1 PLXDC2 SERPINB1 C9orf72 JAML

3.65e-051988451d1c80569f1e307285ba0ebaf5c72e0b5b538864
ToppCellsystemic_lupus_erythematosus-treated-Myeloid|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

CPPED1 PLXDC2 SERPINB1 C9orf72 JAML

3.65e-05198845f37578f156e8aed2ce30cfa837ae04dd18de05d0
ToppCellCOVID-19_Severe-Neu_4|COVID-19_Severe / 5 Neutrophil clusters in COVID-19 patients

IGFBP7 POLE SERPINB1 ANKRD28 AURKB

3.65e-05198845bfdddddef9f3f0eb6af013873dec4e06b7c78c58
ToppCellImmune-monocyte|World / Lineage, Cell type, age group and donor

PIK3AP1 CPPED1 PLXDC2 C9orf72 JAML

3.65e-05198845d3622da252fd580f1dc5c7478a8e23df5ec083cf
ToppCellCOVID-19_Severe-Neu_4|World / 5 Neutrophil clusters in COVID-19 patients

IGFBP7 POLE SERPINB1 ANKRD28 AURKB

3.74e-051998450e327479bbda5a16643cf317d293a2918d619f87
ToppCellBiopsy_Control_(H.)-Epithelial-Proliferating_Epithelial_cells|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

FASN POLE SHCBP1 HUNK AURKB

3.74e-051998454fcf5bec207e4384fd73c5e8801a7e414e3ee7b0
ToppCell10x3'2.3-week_17-19-Myeloid_monocytic-monocyte-CD14_monocyte|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PLXDC2 SERPINB1 CPD C9orf72 JAML

3.74e-0519984550a30d5ee99e51743a0dd60144fc341ff68da9af
ToppCellParenchymal-NucSeq-Immune_Myeloid|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PIK3AP1 CPPED1 P2RX7 PLXDC2 JAML

3.74e-051998457ee2805fd9143eba11bf6832267b62189683608b
ToppCellCOVID_vent-Myeloid|COVID_vent / Disease condition, Lineage, Cell class and subclass

PIK3AP1 CPPED1 PLXDC2 SERPINB1 JAML

3.83e-05200845621af09aae34226902c03edf556562f3ab35a7d8
ToppCellCOVID_vent-Myeloid-Monocytic|COVID_vent / Disease condition, Lineage, Cell class and subclass

PIK3AP1 CPPED1 PLXDC2 SERPINB1 JAML

3.83e-05200845b0a5bee87700ce38f26f95a6f491da7e27cade51
ToppCellBronchial-NucSeq-Immune_Myeloid-Monocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PIK3AP1 CPPED1 P2RX7 PLXDC2 C9orf72

3.83e-052008458872d5fa101d413fb43b4231d476878678543035
ToppCellsevere-immature_Neutrophil|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SHCBP1 SERPINB1 ANKRD28 ENPP4 AURKB

3.83e-052008455ee43386da8261d2e7602a152e6ba4338d844e08
ToppCellsevere-immature_Neutrophil|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

POLE SHCBP1 SERPINB1 ENPP4 AURKB

3.83e-05200845a9b87accdaa6956116ab82427e1330e8f007ef94
ToppCell356C-Fibroblasts-Fibroblast-H-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

PDE6B APBA2 CLIC6 DHX33

1.91e-041518442dc132895609e4efe17954e31f53d9c1ccf256ef
ToppCell356C-Fibroblasts-Fibroblast-H|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

PDE6B APBA2 CLIC6 DHX33

1.91e-0415184422afd8201eff8471da3456be065f2790de5e4bfe
ToppCellP07-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SEC14L3 GIPC2 PLXDC2 DNAH1

2.01e-041538445501095bcf73080872ae01128f21399f9cfc5dd1
ToppCellfacs-Aorta-Heart-18m-Mesenchymal-fibrocyte|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIK3AP1 P2RX7 C4A JAML

2.16e-041568445b56217336771baf57d791efcb4e206c6aea83b1
ToppCellPND03-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZBTB46 SEPTIN3 P2RX7 JAML

2.16e-04156844af47a4b17342bdb3cb62d7e2d52a81168e588629
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

GIPC2 TENM1 ZBTB41 WNK4

2.38e-0416084450d4f867d021abcfeb49e6812bcfd5bb57466a31
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

GIPC2 TENM1 ZBTB41 WNK4

2.38e-041608440f15f895f11dcabb73df79b26bfc4947f38435a7
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

GIPC2 TENM1 ZBTB41 WNK4

2.38e-041608447d004bfe42707605b3851cb2319126acda4d4802
ToppCelldroplet-Liver-nan-3m-Lymphocytic-NK_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERCC6 INTS11 TNKS DNAH8

2.62e-04164844950f87d9dacee45c9004a9bf894543de38f72ee5
ToppCelldroplet-Liver-nan-3m-Lymphocytic-NK/T|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERCC6 INTS11 TNKS DNAH8

2.62e-04164844c33910a6d87580902e9e7bd27afe6ea63b5eff8d
ToppCelldroplet-Liver-nan-3m-Lymphocytic|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERCC6 INTS11 TNKS DNAH8

2.62e-04164844bf0d3ad9016a0b8011a2385bb92f0a4f5edad1d6
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHKA1 ZBTB46 SEPTIN3 SHCBP1

2.68e-041658440edd56e8d14eaeced9882dd9206ea93e8f402e8d
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHKA1 ZBTB46 SEPTIN3 SHCBP1

2.68e-04165844fa3aadfff6fb1e7f142db333c60c2cba02b17e6c
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

C4A C4B ATP1A4 FRMD4B

2.87e-04168844d2b91f2adc95dcfa623f8d7ca2df1c6f884da988
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SEPTIN3 C4orf54 WNK4 AURKB

2.93e-0416984442c31fe94e34f54dbbb5d8b33cedb55badd6232c
ToppCelldroplet-Lung-LUNG-30m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB46 SEPTIN3 PJVK JAML

3.00e-04170844ece7c20e89c190a7ec68032b6c2efeb458c43f9a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Plasmacytoid_Dendritic_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3AP1 KIF1A JAML CNR2

3.07e-04171844af1c93eb75f45c042ea475d93db56e4da207e31f
ToppCellfacs-Lung-Endomucin-3m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SGSM1 APBA2 CRPPA PLEKHA8

3.14e-04172844b3c4adccc34bb9e4e78e40f4e2e23736c347cc75
ToppCelldroplet-Tongue-nan-24m-Epithelial-suprabasal_interpapillary|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SERPINB12 SERPINB1 HERC4 WNK4

3.14e-041728446ece9bb9f31685c918ca4cb7b82cf6ad1cad48af
ToppCellfacs-Lung-Endomucin-3m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SGSM1 APBA2 CRPPA PLEKHA8

3.14e-041728442f1673fcb2356684d60871debb0f159aec553a1c
ToppCelldroplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZBTB46 SEPTIN3 SERPINB12 JAML

3.21e-04173844f66aebceb3eb389bc5ff6c0b398d6f4e9959a14f
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ERCC6 TFB1M DHX33 JAML

3.21e-04173844506efcaa5afd6ed5e565c4c4def6a4505fea97c5
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Lymphocytic-B_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEPTIN3 SHCBP1 CNR2 AURKB

3.21e-04173844a693772987f1baee533dd0bd285a3c7b5619a73b
ToppCellPND07-28-samps-Epithelial-Epithelial-non_alveolar-Ciliated_cell_of_lung_parenchyma|PND07-28-samps / Age Group, Lineage, Cell class and subclass

SEC14L3 GIPC2 CLIC6 DNAH1

3.28e-04174844f41d05a3703d7092bd3c4a97c15ae13069aaa4ad
ToppCelldroplet-Kidney-nan-3m-Lymphocytic-B_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SERPINB1 DNAH8 CNR2 COG8

3.28e-04174844ce9bdd02dc8eb45ba9c1481619c0089b465e6442
ToppCelldroplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEPTIN3 POLE DIS3 AURKB

3.35e-04175844a6913f992a1ea20b43e5adeca3ede3a6fda820ad
ToppCellPND07-28-samps-Epithelial-Epithelial-non_alveolar|PND07-28-samps / Age Group, Lineage, Cell class and subclass

SEC14L3 GIPC2 CLIC6 DNAH1

3.35e-04175844c01a15b2084da4a18f8ff3623f44eb9dfe499f10
ToppCellCOPD-Epithelial-Basal|Epithelial / Disease state, Lineage and Cell class

PLXDC2 SERPINB4 LRRC8A FRMD4B

3.57e-04178844441d1dba720141891b11f404744c59834d80e6c5
ToppCell3'_v3-Lung-Myeloid_Monocytic-Cycling_mono|Lung / Manually curated celltypes from each tissue

POLE SHCBP1 RPP30 USP48

3.57e-0417884467aa17b17da3121c199af45e747c23e2626a9bb2
ToppCelldroplet-Liver-Npc-18m-Lymphocytic-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB46 ERCC6 PJVK TUBGCP5

3.57e-0417884409d2687e0d79f12e90af35fc1c0453d249cf2d19
ToppCellfacs-Marrow-KLS-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB46 SEPTIN3 JAML FRMD4B

3.57e-041788446bad4439a1692332f70135ff446a1048fa4c399d
ToppCellfacs-Marrow-KLS-3m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB46 SEPTIN3 JAML FRMD4B

3.57e-041788443f6feb4ed7779cf5684f52939350b41d7718c3c6
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-CD141+_DCs|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

ZBTB46 CPPED1 ATP7A SEPTIN3

3.65e-0417984499894067e2c2a3ed53abdc5434410c3172693496
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEPTIN3 SLC39A3 SERPINB1 C4B

3.65e-04179844adf8b025032a03dbb58871a92025cd7efbeb22ff
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CEP89 SHCBP1 TENM1 AURKB

3.80e-041818443fe648db1cb8326066d8bde3ca1287c5c9af19bd
ToppCellCOVID-19-kidney-Stressed_PCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

GDA GIPC2 HPD TENM1

3.80e-041818446980ea624151da32b7f537f263e40fcb87a02e81
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial-actively_dividing_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POLE SHCBP1 DNAH8 AURKB

3.88e-04182844bc6a120dedc813c58baac1428c39851a07b71ba7
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial-endothelial_cells_A|E18.5-samps / Age Group, Lineage, Cell class and subclass

P2RX7 POLE DNAH8 AURKB

3.88e-04182844ea4f6c8f600ffe9f8e0609637b3371a5ac48ca03
ToppCell(00)_Basal-(0)_uninjured|(00)_Basal / shred by cell type and Timepoint

SEC14L3 IGFBP7 CLIC6 HUNK

3.88e-04182844c02c9cab4389d80f318f4bb8d703c1e719672624
ToppCellB_cells-ABCs|B_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

RAPGEF6 SERPINB1 DNAH8 AURKB

3.96e-04183844bf9c6fe3ce4e44e4056027257eab8448c39c4fb8
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZBTB46 FASN APBA2 TENM1

4.05e-04184844bd786db4dc4edae6d5cfc0b69901983dea19f729
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZBTB46 ERCC6 CCDC42 JAML

4.05e-041848441c56378b3888c46258d446b47de4d6282fe74b0d
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-5_PVALB_TRIM67|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PHKA1 TENM1 HUNK FRMD4B

4.05e-041848447f6c8912677764d438ab0555faca344d74c2f483
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ZBTB46 ERCC6 CCDC42 JAML

4.05e-04184844a45980306c4e697a2703bed72a7b48fb23d942f4
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RAPGEF6 APBA2 TENM1 FAAH2

4.05e-041848445350b58aa9979631228835d11eb45ddf81d08bff
ToppCellControl-Lymphoid-T_Regulatory|Lymphoid / Disease state, Lineage and Cell class

RAPGEF6 USP48 FRMD4B FAAH2

4.13e-04185844e481cacda0b6b25f5f0062b962df9a442053ac30
ToppCellnormal-na-Myeloid-conventional_dendritic_cell-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

CPPED1 SEPTIN3 PLXDC2 JAML

4.13e-0418584467e881a89a491665b8c612fff084c202c0c79235
ToppCell10x5'-lymph-node_spleen-Myeloid_Dendritic-Cycling_Dendritic|lymph-node_spleen / Manually curated celltypes from each tissue

SEPTIN3 IGFBP7 SHCBP1 AURKB

4.13e-04185844912d8efdc37820dbb07736221a98af929e5a7c97
ToppCellCOVID-19-lung-Plasma_cells_PRDM1/BLIMP_hi|lung / Disease (COVID-19 only), tissue and cell type

SHCBP1 PPCDC ANKRD28 USP48

4.22e-0418684466676d9395172de5707e204826a1c9f73b448cca
ToppCellIPF-Lymphoid-B_Plasma|Lymphoid / Disease state, Lineage and Cell class

SHCBP1 C4A C4B AURKB

4.22e-04186844f9c21daf905d0bb0e0e769ca4bb069ea4b1ba25b
ToppCellPND03|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEC14L3 GDA GIPC2 IGFBP7

4.30e-04187844b3fcb36d853adfdea7172c5591de06f027e50af3
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GDA GIPC2 TENM1 FRMD4B

4.30e-04187844dcf6475ece5b34d9d58a0d1f51c18acedb19c119
ToppCell3'_v3-GI_small-bowel-Lymphocytic_NK-Cycling_NK|GI_small-bowel / Manually curated celltypes from each tissue

IGFBP7 SHCBP1 HUNK AURKB

4.30e-04187844265c690c2921fd201361a0ec8bc4d2a996fbcaf4
ToppCelldroplet-Bladder-Unstain-18m-Epithelial-bladder_mesenchymal_cell_(Scara5+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GDA PLXDC2 PDE6B C4B

4.30e-041878447beba2a5d5978f2ae7d8bde10815705cf2572211
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GDA GIPC2 TENM1 FRMD4B

4.30e-04187844f1356273bd3587b6883295edf15cb9cdb706c057
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GDA SERPINB4 LRRC8A SERPINB1

4.30e-04187844a6a112689d1c9049f57935ad9d2f4955538427de
ToppCell3'_v3-lymph-node_spleen-Myeloid_Dendritic-Cycling_Dendritic|lymph-node_spleen / Manually curated celltypes from each tissue

SEPTIN3 IGFBP7 SHCBP1 AURKB

4.39e-04188844723348a1836a074e068320cb736ce6a953e0038f
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+-Alveolar_macrophage_CCL3+_L.1.0.2.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

STON1 PLXDC2 ANKRD28 ENPP4

4.48e-04189844a59025e82fabd9d60e2438dee85b2644478cc7c8
ToppCellPBMC-Mild-cDC_12|Mild / Compartment, Disease Groups and Clusters

POLE SHCBP1 HIP1R EIF3C

4.48e-04189844946c95d2ecc36b241f58e8c4ad6455fe47c762fa
Diseaseadenoid cystic carcinoma (is_implicated_in)

KMT2C ATR

7.59e-055822DOID:0080202 (is_implicated_in)
DiseaseFrontotemporal Lobar Degeneration

TBK1 C9orf72

1.59e-047822C0751072
DiseaseFrontotemporal Dementia With Motor Neuron Disease

TBK1 C9orf72

2.11e-048822C3888102
Diseaseendometrial cancer (implicated_via_orthology)

ATR POLE

2.11e-048822DOID:1380 (implicated_via_orthology)
Disease2-hydroxyphenylacetate measurement

HPD LRRC8A

2.11e-048822EFO_0800131
Diseasealpha wave measurement, electroencephalogram measurement

TFB1M DNAH1

3.38e-0410822EFO_0004357, EFO_0006870
Diseasenervous system disease (implicated_via_orthology)

KIF1A ATP1A4

4.94e-0412822DOID:863 (implicated_via_orthology)
DiseaseAgammaglobulinemia

LRRC8A SLC39A7

4.94e-0412822C0001768
Diseasecathepsin L1 measurement

PLXDC2 C9orf72

8.93e-0416822EFO_0010619
DiseaseBenign neoplasm of stomach

ATR POLE

1.01e-0317822C0153943
DiseaseNeoplasm of uncertain or unknown behavior of stomach

ATR POLE

1.01e-0317822C0496905
DiseaseCarcinoma in situ of stomach

ATR POLE

1.01e-0317822C0154060
DiseaseMalignant neoplasm of endometrium

ATR POLE

1.13e-0318822C0007103
DiseaseCarcinoma in situ of endometrium

ATR POLE

1.13e-0318822C0346191
Diseaselung cancer (is_implicated_in)

ERCC6 ATR POLE

1.16e-0374823DOID:1324 (is_implicated_in)
Diseaseelectroencephalogram measurement

SGSM1 CRPPA FRMD4B

1.16e-0374823EFO_0004357
Diseaseurinary microalbumin measurement

GDA CRPPA

1.40e-0320822EFO_0010967
DiseaseStomach Neoplasms

KMT2C ATR IGFBP7 POLE AURKB

1.45e-03297825C0038356
DiseaseMalignant neoplasm of stomach

KMT2C ATR IGFBP7 POLE AURKB

1.51e-03300825C0024623
DiseaseStomach Carcinoma

ATR POLE

1.55e-0321822C0699791
Diseaseneuroblastoma, cutaneous melanoma

CPPED1 STON1

2.75e-0328822EFO_0000389, EFO_0000621

Protein segments in the cluster

PeptideGeneStartEntry
GIVFKAKHVETGEIV

CDK20

16

Q8IZL9
AKHVETGEIVALKKV

CDK20

21

Q8IZL9
AVSKVLQIEKEGAIH

C4B

926

P0C0L5
ETINFHEVKEVAGIK

CPSF3

136

Q9UKF6
IEVVKLLVSHGAEVT

ANKRD28

186

O15084
FIFAHVKGIEKEVNV

GIPC2

106

Q8TF65
LEKHKGEILGVVVVE

APBA2

571

Q99767
LFQIVSKHLKEVTEV

CCDC42

266

Q96M95
ALGQEHDITLFVKVK

CLIC6

446

Q96NY7
KLGIVNVDEAVLHFK

PIK3AP1

616

Q6ZUJ8
VLEKLFKKSVGVHSV

ERCC6

1251

Q03468
HKVKVVVFDKTGTIT

ATP7A

1036

Q04656
VFHGVDSKAVFLLKI

CNR2

96

P34972
FVEEGVLLKVVTAAK

CRPPA

161

A4D126
KVKKFRTHVEEGDIV

LRRC8A

246

Q8IWT6
VAEVVTFERGHKIII

KMT2C

4856

Q8NEZ4
FLKKVHETVERGGKV

INTS11

221

Q5TA45
EIHSIGSIIAVEKIV

PHKA1

1141

P46020
VIDYVLHGKEEIKVI

PDE6B

316

P35913
NFIKEGVLVEHVKNV

ENPP4

51

Q9Y6X5
KFDRVKFETLITIHV

DNAH8

1746

Q96JB1
FLKIVELFKEVVVHL

HERC4

556

Q5GLZ8
EDALAKVTKIILAFH

COG8

466

Q96MW5
IEKTIEGIYEKFVIH

TUBGCP5

61

Q96RT8
SFHTVEDLVKVRKEI

POLE

156

Q07864
KEEFTTLQKIVLHEV

PLEKHA8

376

Q96JA3
AKITVVDALHEIPVK

IGFBP7

261

Q16270
DFIKDHLVNTETKVI

PANK4

106

Q9NVE7
GLFGKSTVIIHVIDV

PCDHB11

326

Q9Y5F2
VHTKVKGIAEVKEEI

P2RX7

61

Q99572
VENGVKKLVHSVFDT

P2RX7

76

Q99572
GTEITHAVVIKKLNE

EIF3C

321

Q99613
HKGQIEVESETIFKL

FRMD4B

166

Q9Y2L6
HIESISKVAEVAGKE

DNAH1

1141

Q9P2D7
GEVVNEKAKTHVLDI

ATR

2581

Q13535
DKVVLHTGKYEELIV

HIP1R

891

O75146
GKIAVEVHKSIVNEL

CEP89

506

Q96ST8
HVLTGEKVAIKVIDK

HUNK

81

P57058
LIEKVHIGVKGFVKD

CPD

376

O75976
IHTDVLFGVVKAAQK

DHX33

201

Q9H6R0
LADKFIHAGVKVVFS

CPPED1

231

Q9BRF8
KKVVVHLETILGASV

FAAH2

331

Q6GMR7
GFLNVLEVLKHEVKI

GDA

311

Q9Y2T3
RDIFISKIVHKSFVE

SERPINB1

311

P30740
GKHIGKVVVQVLAEE

FASN

1846

P49327
ALEFVVSKVEGEIKH

C4orf54

716

D6RIA3
FVHAKKVSFTVEVLL

SEC14L3

371

Q9UDX4
DVKFFVLSEKGVIIV

C9orf72

81

Q96LT7
AVSKVLQIEKEGAIH

C4A

926

P0C0L4
LVHRVAIVSEKGEVK

KIF1A

866

Q12756
KEVAGLVTLKHVYEI

MRPL11

106

Q9Y3B7
SVVAINHIVDFKEKK

RPP30

31

P78346
EVVSHVIKQGKIVFV

HPD

56

P32754
DAEKVHFILVEKVTT

TRMT13

206

Q9NUP7
HFILVEKVTTRFKVD

TRMT13

211

Q9NUP7
IISKDTTAKEVVFHA

RAPGEF6

766

Q8TEU7
HSFDKKGVIVVEVED

TACO1

181

Q9BSH4
KGESQVFKKAVVLHV

JAML

121

Q86YT9
VKVGLSDAFVVVHRI

PLXDC2

276

Q6UX71
KVVSLFVGVAVHETL

SLC39A3

196

Q9BRY0
RIVHGDVLTFKVEKA

TFB1M

106

Q8WVM0
IKFAIKDGIVTADII

TENM1

2526

Q9UKZ4
IKISGIKFVQHDAVE

SHCBP1

431

Q8NEM2
IEDTVFHVFDKVKVK

DIS3

896

Q9Y2L1
KGIDNHTKEVVAIKI

STK25

36

O00506
LSKIIHKTFVEVDEN

SERPINB12

341

Q96P63
AKAIVVHGAELKDIQ

ATP1A4

666

Q13733
TIVDKVKEVLFQHSG

PPCDC

186

Q96CD2
KVLFKSQIEKEGVEH

AURKB

106

Q96GD4
VFKAIHKESGQVVAI

STK3

41

Q13188
SKHELVFVDTKGVVK

ZBTB11

176

O95625
AVKASFGIVTKHEVE

PJVK

111

Q0ZLH3
ENFSVAGKIHTVKIE

STON1

336

Q9Y6Q2
GIVAFLVVEKFVRHV

SLC39A7

226

Q92504
KTVEIKAIGHVIEEG

SEPTIN3

101

Q9UH03
LHEAAIKGKIDVCIV

TNKS

286

O95271
LIIVEGKEFSAHKVV

ZBTB41

91

Q5SVQ8
VVIIDISKKGEVIHR

GEMIN5

176

Q8TEQ6
SKVLHKAFVEVTEEG

SERPINB4

326

P48594
IRTALFEKVLDKIVH

SGSM1

131

Q2NKQ1
ILKKLVIHFGVVDFL

TMEM245

386

Q9H330
VVFKHEKEDGAISTI

CCT8

361

P50990
FVVDHVIKITRIEVG

USP48

811

Q86UV5
SFHKVKIPEVKEIIE

WNK4

396

Q96J92
GEKVKVEHVVSVLEK

UGGT1

581

Q9NYU2
VVEGKVFKAHKNVLL

ZBTB46

36

Q86UZ6
ETVHKKTEVVITLDF

TBK1

456

Q9UHD2
EFSALVAIKEKIHIL

nan

106

Q9UFV3