Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP-dependent activity

KIF9 DDX17 SPAST ACSBG1 CECR2 HELZ CHD9 DDX53 MSH3 DDX43 MORC2 DNAH1

3.80e-066147712GO:0140657
GeneOntologyMolecularFunction5-methylcytosine dioxygenase activity

TET2 TET3

4.39e-053772GO:0070579
GeneOntologyMolecularFunctiontranscription coactivator activity

MED20 ZCCHC12 DDX17 TCF20 SS18L1 THRAP3 ZFPM2

1.68e-04303777GO:0003713
GeneOntologyMolecularFunctionhelicase activity

DDX17 HELZ CHD9 DDX53 DDX43

3.64e-04158775GO:0004386
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

MED20 DUS2 DDX17 CECR2 HELZ CHD9 DDX53 MSH3 DDX43

8.24e-04645779GO:0140640
GeneOntologyMolecularFunctioncysteine-type peptidase activity

USP53 CAPN7 USP20 OTUD7B ALG13

8.80e-04192775GO:0008234
GeneOntologyMolecularFunctioncysteine-type deubiquitinase activity

USP53 USP20 OTUD7B ALG13

9.89e-04114774GO:0004843
GeneOntologyMolecularFunctiondeubiquitinase activity

USP53 USP20 OTUD7B ALG13

1.35e-03124774GO:0101005
GeneOntologyMolecularFunctionpyrophosphatase activity

PRUNE2 KIF9 DDX17 SPAST LSG1 CHD9 DDX53 DDX43 MORC2 GPN3

1.39e-038397710GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

PRUNE2 KIF9 DDX17 SPAST LSG1 CHD9 DDX53 DDX43 MORC2 GPN3

1.41e-038407710GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

PRUNE2 KIF9 DDX17 SPAST LSG1 CHD9 DDX53 DDX43 MORC2 GPN3

1.41e-038407710GO:0016818
GeneOntologyMolecularFunctiontranscription coregulator activity

MED20 ZCCHC12 DDX17 TCF20 SS18L1 CAMTA1 THRAP3 ZFPM2

1.43e-03562778GO:0003712
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

MED20 ZCCHC12 DDX17 TCF20 CDC42SE2 SS18L1 IRS1 DTX3L CAMTA1 HNRNPA2B1 THRAP3 ZFPM2

1.54e-0311607712GO:0030674
GeneOntologyMolecularFunctionATP hydrolysis activity

KIF9 DDX17 SPAST CHD9 DDX53 DDX43 MORC2

1.55e-03441777GO:0016887
GeneOntologyMolecularFunctionmolecular adaptor activity

MED20 ZCCHC12 DDX17 TCF20 CDC42SE2 SS18L1 IRS1 DTX3L CAMTA1 HNRNPA2B1 THRAP3 ZFPM2 AXIN2

1.92e-0313567713GO:0060090
GeneOntologyMolecularFunctionubiquitin-like protein peptidase activity

USP53 USP20 OTUD7B ALG13

1.95e-03137774GO:0019783
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

KIF9 DDX17 SPAST LSG1 CHD9 DDX53 DDX43 MORC2 GPN3

2.91e-03775779GO:0017111
GeneOntologyMolecularFunctionRNA helicase activity

DDX17 DDX53 DDX43

3.41e-0378773GO:0003724
GeneOntologyMolecularFunctionHMG box domain binding

POU3F2 POU3F3

3.52e-0323772GO:0071837
GeneOntologyMolecularFunctionATP-dependent activity, acting on RNA

DDX17 DDX53 DDX43

3.66e-0380773GO:0008186
Domain-

CUX2 POU1F1 POU3F2 POU3F3

4.14e-06277641.10.260.40
DomainLambda_DNA-bd_dom

CUX2 POU1F1 POU3F2 POU3F3

5.57e-0629764IPR010982
DomainPOU

POU1F1 POU3F2 POU3F3

3.49e-0516763SM00352
DomainPOU_2

POU1F1 POU3F2 POU3F3

3.49e-0516763PS00465
DomainPOU_dom

POU1F1 POU3F2 POU3F3

3.49e-0516763IPR000327
DomainPOU_3

POU1F1 POU3F2 POU3F3

3.49e-0516763PS51179
DomainPou

POU1F1 POU3F2 POU3F3

3.49e-0516763PF00157
DomainPOU_1

POU1F1 POU3F2 POU3F3

3.49e-0516763PS00035
DomainPOU

POU1F1 POU3F2 POU3F3

4.23e-0517763IPR013847
DomainTF_POU_3

POU3F2 POU3F3

9.75e-054762IPR016362
DomainP-loop_NTPase

KIF9 DDX17 SPAST LSG1 HELZ CHD9 DDX53 MSH3 DDX43 CAMTA1 GPN3 DNAH1

1.51e-048487612IPR027417
DomainDEAD_ATP_HELICASE

DDX17 DDX53 DDX43

2.68e-0431763PS00039
DomainRNA-helicase_DEAD-box_CS

DDX17 DDX53 DDX43

3.24e-0433763IPR000629
DomainQ_MOTIF

DDX17 DDX53 DDX43

4.55e-0437763PS51195
DomainRNA_helicase_DEAD_Q_motif

DDX17 DDX53 DDX43

4.55e-0437763IPR014014
DomainMIT

SPAST CAPN7

7.20e-0410762SM00745
DomainMIT

SPAST CAPN7

7.20e-0410762PF04212
Domain-

DDX17 SPAST LSG1 HELZ CHD9 DDX53 MSH3 DDX43 GPN3 DNAH1

8.57e-0474676103.40.50.300
DomainHelicase_C

DDX17 CHD9 DDX53 DDX43

9.52e-04107764PF00271
DomainHELICc

DDX17 CHD9 DDX53 DDX43

9.52e-04107764SM00490
DomainHomeobox_CS

CUX2 POU1F1 POU3F2 POU3F3 TLX1

9.68e-04186765IPR017970
DomainHelicase_C

DDX17 CHD9 DDX53 DDX43

9.85e-04108764IPR001650
DomainHELICASE_CTER

DDX17 CHD9 DDX53 DDX43

1.02e-03109764PS51194
DomainHELICASE_ATP_BIND_1

DDX17 CHD9 DDX53 DDX43

1.02e-03109764PS51192
DomainDEXDc

DDX17 CHD9 DDX53 DDX43

1.02e-03109764SM00487
DomainHelicase_ATP-bd

DDX17 CHD9 DDX53 DDX43

1.05e-03110764IPR014001
DomainOTU

OTUD7B ALG13

1.24e-0313762PF02338
DomainMIT

SPAST CAPN7

1.44e-0314762IPR007330
DomainOTU

OTUD7B ALG13

1.66e-0315762PS50802
DomainOTU_dom

OTUD7B ALG13

1.66e-0315762IPR003323
DomainUBA-like

VPS13D UBAP2 OTUD7B

2.26e-0364763IPR009060
DomainHomeobox

CUX2 POU1F1 POU3F2 POU3F3 TLX1

2.65e-03234765PF00046
DomainHOMEOBOX_1

CUX2 POU1F1 POU3F2 POU3F3 TLX1

2.75e-03236765PS00027
DomainHOX

CUX2 POU1F1 POU3F2 POU3F3 TLX1

2.80e-03237765SM00389
DomainHOMEOBOX_2

CUX2 POU1F1 POU3F2 POU3F3 TLX1

2.91e-03239765PS50071
DomainHomeobox_dom

CUX2 POU1F1 POU3F2 POU3F3 TLX1

2.91e-03239765IPR001356
DomainDEAD/DEAH_box_helicase_dom

DDX17 DDX53 DDX43

3.28e-0373763IPR011545
DomainDEAD

DDX17 DDX53 DDX43

3.28e-0373763PF00270
Domain-

CUX2 POU1F1 POU3F2 POU3F3 TLX1

5.93e-032837651.10.10.60
DomainUBA

VPS13D UBAP2

6.60e-0330762SM00165
Pubmed

Expression of a large family of POU-domain regulatory genes in mammalian brain development.

POU1F1 POU3F2 POU3F3

2.08e-0767732739723
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

USP53 TET2 VPS13D PTPN13 UBAP2 SPAST TCF20 LSG1 HELZ IRS1 MTCL1 CIC

4.13e-07861771236931259
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

PTPN13 TCF20 ROR1 ZDHHC5 TENM1 HELZ HNRNPA2B1

2.00e-0626377734702444
Pubmed

A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure.

TET2 CECR2 TET3

2.94e-061377326989192
Pubmed

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.

SART1 TET2 UBAP2 DDX17 DSG1 UBR4 HNRNPA2B1 THRAP3 ALG13

3.65e-0655177934728620
Pubmed

Tet1 controls meiosis by regulating meiotic gene expression.

TET2 SS18L1 TET3

3.73e-061477323151479
Pubmed

Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex.

CUX2 POU3F2 POU3F3

4.66e-061577318255031
Pubmed

Acute loss of TET function results in aggressive myeloid cancer in mice.

TET2 TET3

4.84e-06277226607761
Pubmed

The putative tumor suppressor gene PTPN13/PTPL1 induces apoptosis through insulin receptor substrate-1 dephosphorylation.

PTPN13 IRS1

4.84e-06277217638892
Pubmed

Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma.

TET2 TET3

4.84e-06277227852070
Pubmed

TET proteins regulate Drosha expression and impact microRNAs in iNKT cells.

TET2 TET3

4.84e-06277239364402
Pubmed

Protein-tyrosine phosphatase PTPL1/FAP-1 triggers apoptosis in human breast cancer cells.

PTPN13 IRS1

4.84e-06277212354757
Pubmed

Ten-eleven translocation (Tet) methylcytosine dioxygenase-dependent viral DNA demethylation mediates in vivo hepatitis B virus (HBV) biosynthesis.

TET2 TET3

4.84e-06277238179947
Pubmed

TET2 and TET3 loss disrupts small intestine differentiation and homeostasis.

TET2 TET3

4.84e-06277237414790
Pubmed

TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells.

TET2 TET3

4.84e-06277231120187
Pubmed

Role of Chromatin Remodeling Genes and TETs in the Development of Human Midbrain Dopaminergic Neurons.

TET2 TET3

4.84e-06277232367481
Pubmed

Molecular pathogenesis of progression to myeloid leukemia from TET-insufficient status.

TET2 TET3

4.84e-06277232126143
Pubmed

Distinct roles for TET family proteins in regulating human erythropoiesis.

TET2 TET3

4.84e-06277228167661
Pubmed

Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms.

TET2 TET3

4.84e-06277227729528
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

USP53 PRUNE2 CUX2 UBAP2 UBR4 CAMTA1 CIC OTUD7B

5.11e-0643077835044719
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

SART1 MED20 TET2 DDX17 SPAST TCF20 CHD9 RRM1 MORC2 HNRNPA2B1 THRAP3 CIC

5.37e-061103771234189442
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

ASRGL1 UBAP2 DDX17 SPAST DSG1 ACSBG1 UBR4 TENM1 KCNQ2 HELZ PCCA THRAP3

7.42e-061139771236417873
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

SART1 PTPN13 DDX17 LSG1 ZDHHC5 MUC16 PCCA HNRNPA2B1 THRAP3 OTUD7B

8.32e-06777771035844135
Pubmed

Expression of TET and 5-HmC in Trophoblast Villi of Women with Normal Pregnancy and with Early Pregnancy Loss.

TET2 TET3

1.45e-05377230074219
Pubmed

Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter.

TET2 TET3

1.45e-05377224194590
Pubmed

TET proteins in malignant hematopoiesis.

TET2 TET3

1.45e-05377219923888
Pubmed

Selective targeting of TET catalytic domain promotes somatic cell reprogramming.

TET2 TET3

1.45e-05377232024762
Pubmed

Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs.

TET2 TET3

1.45e-05377227184841
Pubmed

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.

TET2 TET3

1.45e-05377221778364
Pubmed

Tet family proteins and 5-hydroxymethylcytosine in development and disease.

TET2 TET3

1.45e-05377222569552
Pubmed

Postnatal DNA demethylation and its role in tissue maturation.

TET2 TET3

1.45e-05377229795194
Pubmed

Class III POU genes: generation of homopolymeric amino acid repeats under GC pressure in mammals.

POU3F2 POU3F3

1.45e-0537728703082
Pubmed

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.

TET2 TET3

1.45e-05377219372391
Pubmed

Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs.

TET2 TET3

1.45e-05377230987683
Pubmed

Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation.

TET2 TET3

1.45e-05377229048538
Pubmed

Mechanisms of TET protein-mediated DNA demethylation and its role in the regulation of mouse development.

TET2 TET3

1.45e-05377225608811
Pubmed

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.

TET2 TET3

1.45e-05377219420352
Pubmed

Overexpression of TET dioxygenases in seminomas associates with low levels of DNA methylation and hydroxymethylation.

TET2 TET3

1.45e-05377228218476
Pubmed

Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine.

TET2 TET3

1.45e-05377223548903
Pubmed

5-Hydroxymethylcytosine-mediated active demethylation is required for mammalian neuronal differentiation and function.

TET2 TET3

1.45e-05377234919053
Pubmed

Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells.

TET2 TET3

1.45e-05377224958354
Pubmed

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering.

TET2 TET3

1.45e-05377223643243
Pubmed

Tissue-specific DNA demethylation is required for proper B-cell differentiation and function.

TET2 TET3

1.45e-05377227091986
Pubmed

Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation.

TET2 TET3

1.45e-05377234879277
Pubmed

Oxygen regulation of TET enzymes.

TET2 TET3

1.45e-05377233410283
Pubmed

Effect of aging on 5-hydroxymethylcytosine in brain mitochondria.

TET2 TET3

1.45e-05377222445327
Pubmed

Control of Foxp3 stability through modulation of TET activity.

TET2 TET3

1.45e-05377226903244
Pubmed

Loss of Tet enzymes compromises proper differentiation of embryonic stem cells.

TET2 TET3

1.45e-05377224735881
Pubmed

Differential expression of ten-eleven translocation genes in endometrial cancers.

TET2 TET3

1.45e-05377228349832
Pubmed

The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon.

POU3F2 POU3F3

1.45e-05377216547000
Pubmed

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification.

TET2 TET3

1.45e-05377220639862
Pubmed

Ten-Eleven Translocation Genes are Downregulated in Endometriosis.

TET2 TET3

1.45e-05377226917261
Pubmed

Iron-dependent epigenetic modulation promotes pathogenic T cell differentiation in lupus.

TET2 TET3

1.45e-05377235499082
Pubmed

TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells.

TET2 TET3

1.45e-05377227869820
Pubmed

TET2 promotes histone O-GlcNAcylation during gene transcription.

TET2 TET3

1.45e-05377223222540
Pubmed

Alternation of ten-eleven translocation 1, 2, and 3 expression in eutopic endometrium of women with endometriosis-associated infertility.

TET2 TET3

1.45e-05377230130982
Pubmed

Regulation of DNA methylation signatures on NF-κB and STAT3 pathway genes and TET activity in cigarette smoke extract-challenged cells/COPD exacerbation model in vitro.

TET2 TET3

1.45e-05377232342329
Pubmed

High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.

SART1 KIF9 UBAP2 DDX17 TCF20 SUGCT SS18L1 CAMTA1 PCCA HNRNPA2B1 OTUD7B

1.51e-051021771126760575
Pubmed

Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion.

CUX2 POU3F2 POU3F3

2.32e-052577339271675
Pubmed

Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis.

TET2 TET3

2.89e-05477235235365
Pubmed

Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression.

TET2 TET3

2.89e-05477230726915
Pubmed

Mutually repressive interaction between Brn1/2 and Rorb contributes to the establishment of neocortical layer 2/3 and layer 4.

POU3F2 POU3F3

2.89e-05477226951672
Pubmed

Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine.

TET2 TET3

2.89e-05477221321204
Pubmed

Paradoxical association of TET loss of function with genome-wide DNA hypomethylation.

TET2 TET3

2.89e-05477231371502
Pubmed

Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked β-N-acetylglucosamine transferase (OGT).

TET2 TET3

2.89e-05477224394411
Pubmed

Activation-induced cytidine deaminase alters the subcellular localization of Tet family proteins.

TET2 TET3

2.89e-05477223028748
Pubmed

Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules.

TET2 TET3

2.89e-05477230554962
Pubmed

TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS.

TET2 TET3

2.89e-05477223353889
Pubmed

Structure and evolution of four POU domain genes expressed in mouse brain.

POU3F2 POU3F3

2.89e-0547721565620
Pubmed

Genome-wide DNA methylation analysis reveals a potential mechanism for the pathogenesis and development of uterine leiomyomas.

COL6A3 IRS1

2.89e-05477223818951
Pubmed

TET1 Directs Chondrogenic Differentiation by Regulating SOX9 Dependent Activation of Col2a1 and Acan In Vitro.

TET2 TET3

2.89e-05477233134768
Pubmed

Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT).

TET2 TET3

2.89e-05477225568311
Pubmed

Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development.

TET2 TET3

2.89e-05477231541101
Pubmed

Structure and regulation of the human growth hormone-releasing hormone receptor gene.

POU1F1 POU3F2

2.89e-0547729482665
Pubmed

Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility.

TET2 TET3

2.89e-05477227869616
Pubmed

Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells.

POU3F2 POU3F3

2.89e-05477226265007
Pubmed

The intrinsic and extrinsic effects of TET proteins during gastrulation.

TET2 TET3

2.89e-05477235908548
Pubmed

Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.

TCF20 IRS1 ADCY5

2.94e-052777320490451
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

SART1 PTPN13 UBAP2 DSG1 LSG1 HELZ C16orf96 MORC2 THRAP3

3.19e-0572477936232890
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

SART1 TET2 DDX17 UBR4 HNRNPA2B1 THRAP3

3.22e-0527277631010829
Pubmed

DNA demethylation fine-tunes IL-2 production during thymic regulatory T cell differentiation.

TET2 TET3

4.82e-05577236880575
Pubmed

The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U.

POU3F2 POU3F3

4.82e-0557729105675
Pubmed

Dynamic expression of TET1, TET2, and TET3 dioxygenases in mouse and human placentas throughout gestation.

TET2 TET3

4.82e-05577229108636
Pubmed

Cooperative function of POU proteins and SOX proteins in glial cells.

POU3F2 POU3F3

4.82e-0557729632656
Pubmed

The subventricular zone is the developmental milestone of a 6-layered neocortex: comparisons in metatherian and eutherian mammals.

CUX2 POU3F2

4.82e-05577219726493
Pubmed

CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element.

TET2 TET3

4.82e-05577235304452
Pubmed

Loss of TET2 and TET3 in regulatory T cells unleashes effector function.

TET2 TET3

4.82e-05577231043609
Pubmed

TET is targeted for proteasomal degradation by the PHD-pVHL pathway to reduce DNA hydroxymethylation.

TET2 TET3

4.82e-05577232963106
Pubmed

Lineage-specific functions of TET1 in the postimplantation mouse embryo.

TET2 TET3

4.82e-05577228504700
Pubmed

Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression.

TET2 TET3

4.82e-05577235737830
Pubmed

CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases.

TET2 TET3

4.82e-05577225557551
Pubmed

Frequent somatic mutations in epigenetic regulators in newly diagnosed chronic myeloid leukemia.

TET2 TET3

4.82e-05577228452984
Pubmed

TET-Mediated Sequestration of miR-26 Drives EZH2 Expression and Gastric Carcinogenesis.

TET2 TET3

4.82e-05577228923852
Pubmed

Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a.

TET2 TET3

4.82e-05577223820384
Pubmed

TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.

COL6A3 DDX17 SUGCT RRM1 THRAP3

5.00e-0517977536261009
Pubmed

Tet2- and Tet3- Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment.

TET2 TET3 AXIN2

5.43e-053377336522157
Pubmed

Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin.

USP53 USP20 OTUD7B

5.43e-053377330323974
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

SART1 DUS2 DDX17 TCF20 DSG1 SGCD LSG1 PCCA HNRNPA2B1 THRAP3

6.46e-05989771036424410
Pubmed

Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development.

CUX2 POU3F2 POU3F3

6.49e-053577322991445
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

SART1 UBAP2 TCF20 DSG1 LSG1 ZDHHC5 POU3F3 IRS1 DTX3L HNRNPA2B1 THRAP3

6.69e-051203771129180619
InteractionTLE3 interactions

TBX15 TET2 DDX17 TCF20 CAPN7 CECR2 HELZ CIC TLX1 ALG13

1.45e-063767610int:TLE3
InteractionERG interactions

TET2 TCF20 SS18L1 UBR4 MSH3 HNRNPA2B1 CIC

2.11e-05223767int:ERG
InteractionRNF43 interactions

PTPN13 DDX17 TCF20 ROR1 ZDHHC5 TENM1 HELZ HNRNPA2B1 ALG13

3.21e-05427769int:RNF43
InteractionFMR1 interactions

UBAP2 SPAST TCF20 CECR2 UBR4 MTCL1 HNRNPA2B1 THRAP3 ZFPM2 ALG13

3.22e-055367610int:FMR1
Cytoband3q21.1

DTX3L ADCY5

5.17e-04207723q21.1
Cytoband20q13.3

SS18L1 KCNQ2

5.17e-042077220q13.3
Cytoband2p13.1

ACTG2 TET3

1.50e-03347722p13.1
GeneFamilyPOU class homeoboxes and pseudogenes

POU1F1 POU3F2 POU3F3

3.00e-0523483523
GeneFamilyDEAD-box helicases

DDX17 DDX53 DDX43

1.87e-0442483499
GeneFamilyOTU domain containing

OTUD7B ALG13

9.15e-0417482669
CoexpressionAtlasdev gonad_e11.5_M_GonadVasMes_Flk_top-relative-expression-ranked_500

MED20 COL6A3 CACNA2D1 PTPN13 FAT3 ROR1 MUC16 IRS1 ZFPM2

1.45e-05418749gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_500

CACNA2D1 CUX2 FAT3 ROR1 ACTG2 DTX3L MTCL1 ADCY5

8.49e-05407748gudmap_developingLowerUrinaryTract_e14.5_ urethra_500
CoexpressionAtlasdev gonad_e11.5_M_GonadVasMes_Flk_k-means-cluster#4_top-relative-expression-ranked_500

COL6A3 CACNA2D1 FAT3 ROR1 MUC16 IRS1

8.52e-05207746gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_k4_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_top-relative-expression-ranked_500

CACNA2D1 FAT3 ROR1 ACTG2 MSH3 DTX3L MTCL1 ADCY5

8.64e-05408748DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_top-relative-expression-ranked_500

CACNA2D1 CUX2 FAT3 ROR1 TENM1 KCNQ2 MSH3 DTX3L

1.18e-04427748DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_500
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRUNE2 COL6A3 SGCD FAT3 ROR1 ACTG2 IRS1 MTCL1 ZFPM2

4.05e-111887793177b2c1723268d330d3e9f24f9e24492ace6286
ToppCellControl-Fibroblasts-Airway_smooth_muscle|Control / group, cell type (main and fine annotations)

PRUNE2 CACNA2D1 SUGCT SGCD FAT3 ACTG2 ADCY5 ZFPM2

9.33e-10180778d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCellCOVID-19-Fibroblasts-Airway_smooth_muscle|COVID-19 / group, cell type (main and fine annotations)

USP53 PRUNE2 COL6A3 CACNA2D1 SUGCT ROR1 ACTG2 ADCY5

1.26e-09187778464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRUNE2 COL6A3 CACNA2D1 SGCD ACTG2 IRS1 ADCY5 ZFPM2

1.37e-091897787ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRUNE2 COL6A3 SGCD ACTG2 IRS1 COX4I2 ADCY5 ZFPM2

1.49e-0919177808042952431ca1a6fd7dfc13f36eb28643979598
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRUNE2 COL6A3 CACNA2D1 SGCD ACTG2 IRS1 COX4I2 ADCY5

1.49e-091917787853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PRUNE2 CACNA2D1 SGCD FAT3 ACTG2 ADCY5 ZFPM2

2.11e-08173777cb6389536195443633adb06e5f1b7483530773d1
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

USP53 COL6A3 CACNA2D1 PTPN13 SUGCT SGCD ROR1

3.60e-08187777a9316e2818217ec5feae9cf8816f7249803caee6
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRUNE2 COL6A3 SGCD ACTG2 IRS1 MTCL1 ZFPM2

3.74e-08188777293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRUNE2 SGCD FAT3 ROR1 ACTG2 ADCY5 ZFPM2

3.87e-0818977745e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRUNE2 SGCD ACTG2 IRS1 COX4I2 ADCY5 ZFPM2

4.32e-08192777992d08092edbc68c47b945deb8708379738c239a
ToppCellnucseq-Mesenchymal-Myocytic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

COL6A3 SUGCT ACTG2 IRS1 COX4I2 ADCY5 ZFPM2

4.63e-081947772d66091097e106c7bee22e5281f50724700bdf8d
ToppCellCOVID-19-Fibroblasts|COVID-19 / group, cell type (main and fine annotations)

USP53 COL6A3 CACNA2D1 SUGCT SGCD ROR1 ZFPM2

5.15e-08197777fb847f2277609c31fffcdf49517243ce0684facf
ToppCellbackground-Hepatic_Stellate_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

COL6A3 CACNA2D1 PTPN13 SGCD FAT3 ADCY5 ZFPM2

5.33e-08198777bd11b0e9e80449aab979a02c1023e0638c431c7c
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

USP53 COL6A3 CACNA2D1 SGCD FAT3 CATSPERB

6.62e-0717877609475e522dc1b8cf9ff1c25de5d1e3082b162948
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

USP53 COL6A3 CACNA2D1 SGCD FAT3 CATSPERB

6.62e-0717877635de8f791b0e78a6caf52ff095f05e204a59e828
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

USP53 COL6A3 CACNA2D1 SGCD FAT3 CATSPERB

6.62e-07178776000d25f3f13cc76cf39c46c312c6fafc2ea4f368
ToppCellFetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PRUNE2 ACTG2 IRS1 MTCL1 ADCY5 ZFPM2

7.30e-0718177625915e2500430a902db37d79a749ce2990b69810
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRUNE2 COL6A3 CACNA2D1 SGCD ACTG2 ADCY5

7.30e-07181776b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRUNE2 COL6A3 SGCD ACTG2 IRS1 ZFPM2

8.29e-07185776e64e8c98dd88d91f6501d3fb10b60fd2f3c90af3
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRUNE2 SGCD ACTG2 IRS1 MTCL1 ZFPM2

8.56e-071867766add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

COL6A3 CACNA2D1 SUGCT SGCD FAT3 ZFPM2

8.83e-07187776bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

PRUNE2 TENM1 ACTG2 IRS1 MTCL1 COX4I2

9.39e-07189776b6d5dec55bf352f6ae19d8f488ae70aa10fb9a8f
ToppCellMesenchymal-airway_smooth_muscle_cell|World / Lineage, Cell type, age group and donor

PRUNE2 ACTG2 IRS1 MTCL1 ADCY5 ZFPM2

9.69e-07190776645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCellControl-Fibroblasts|Control / group, cell type (main and fine annotations)

USP53 COL6A3 CACNA2D1 SGCD FAT3 ZFPM2

9.69e-071907763a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRUNE2 SGCD ROR1 ACTG2 ADCY5 ZFPM2

9.99e-07191776b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCellCOVID-19-Fibroblasts-Other_FB|COVID-19 / group, cell type (main and fine annotations)

COL6A3 CACNA2D1 SUGCT SGCD ROR1 ZFPM2

1.06e-06193776e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

COL6A3 SUGCT SGCD ACTG2 IRS1 ZFPM2

1.06e-061937765de87fc94a6e58899ef4124cf4887ed3ff96163a
ToppCellChildren_(3_yrs)-Mesenchymal|Children_(3_yrs) / Lineage, Cell type, age group and donor

USP53 COL6A3 CACNA2D1 SGCD FAT3 ZFPM2

1.16e-06196776bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCellPCW_13-14-Mesenchymal|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

COL6A3 CACNA2D1 SGCD FAT3 ROR1 ZFPM2

1.20e-0619777673a2085d2682d636726a5432d572ae2a3fbe1c3f
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

COL6A3 CACNA2D1 SGCD FAT3 ROR1 ZFPM2

1.23e-0619877617dc055e2a289496d9c5cdbf3297bdf906dc6d22
ToppCellPCW_10-12-Mesenchymal|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

COL6A3 CACNA2D1 SGCD FAT3 ROR1 ZFPM2

1.27e-06199776a09292de4c4447b8eee55d401808e43b817321cc
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

PRUNE2 SGCD ACTG2 IRS1 ADCY5 ZFPM2

1.31e-06200776c5e051f1aac8dda376c342a9932785a23450e073
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

PRUNE2 COL6A3 SGCD ACTG2 IRS1 ZFPM2

1.31e-062007769d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PRUNE2 COL6A3 SGCD ACTG2 IRS1 ZFPM2

1.31e-0620077687827041663013f5e7273168dc8709d69840e7ce
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PRUNE2 COL6A3 ACTG2 IRS1 MTCL1 ZFPM2

1.31e-06200776c596a53c0b63c9deaac7d99fcbdd94ecfa96b86c
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PRUNE2 COL6A3 SGCD ACTG2 IRS1 ZFPM2

1.31e-062007768988f113708eef7d9d2a6a6c1bcfd7c8f9804d3e
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PRUNE2 COL6A3 ACTG2 IRS1 ADCY5 ZFPM2

1.31e-0620077608bf8c00eee6468215edb3611296bfc8784c4d56
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PRUNE2 ACTG2 IRS1 MTCL1 ADCY5 ZFPM2

1.31e-06200776dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

PRUNE2 FAT3 ACTG2 ADCY5 ZFPM2

7.36e-06155775cd7d95cbcad248670e531d80bb83c55e36ebc573
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

COL6A3 FAT3 ACTG2 IRS1 MTCL1

7.83e-06157775b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 ROR1 IRS1 ZFPM2 AXIN2

8.33e-06159775330ecbba97d47bc818a5e8d1d84b05d056bd831e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 ROR1 IRS1 ZFPM2 AXIN2

8.33e-06159775cbb331eb689d8cea9e1146ba85e0a05d23301c47
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

PRUNE2 ACTG2 IRS1 ADCY5 ZFPM2

9.68e-06164775e3983f655cdba308fb192182829f17bef99ce0ba
ToppCellfacs-Heart-LV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROR1 MTCL1 COX4I2 ADCY5 ZFPM2

1.25e-05173775d78397e65e997ddb995111a810f0e2a4f67d0765
ToppCellfacs-Heart-LV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROR1 MTCL1 COX4I2 ADCY5 ZFPM2

1.25e-051737753c852ffe22f4a5b632463086b08c669310684e80
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRUNE2 COL6A3 ACSBG1 MUC16 ADCY5

1.29e-051747754da79da7a09ee1e345102c5331675ebcdbe56171
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

PRUNE2 ACTG2 IRS1 ADCY5 ZFPM2

1.40e-05177775b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PRUNE2 FAT3 ACTG2 MTCL1 ADCY5

1.48e-05179775e860dca9b28ac5af61804bfd729cd39257cdb352
ToppCellfacs-Lung-Endomucin-24m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SGCD ACTG2 MTCL1 COX4I2 TMEM200A

1.60e-05182775be9c312a44868d4ee266a64d066feb8c5bce5687
ToppCellfacs-Lung-Endomucin-24m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SGCD ACTG2 MTCL1 COX4I2 TMEM200A

1.60e-0518277574dbb706bcaa0f8c922bf3b0424bce5bb27167fa
ToppCell10x5'v1-week_17-19-Lymphocytic_T-T_NK-Treg|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

USP53 TENM1 ACTG2 MORC2 TMEM200A

1.64e-051837755fb933acfe6bc555c90dba71e75d4be658763945
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_3|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

COL6A3 FAT3 ROR1 IRS1 AXIN2

1.64e-05183775f4ea7113ce9099222743d9ff02388d3d8a9e987b
ToppCell21-Trachea-Mesenchymal-Airway_Smooth_Muscle|Trachea / Age, Tissue, Lineage and Cell class

COL6A3 SGCD ACTG2 IRS1 ZFPM2

1.69e-0518477586a96cd88e50eacad1f0badfbbf6dc626f41725e
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

COL6A3 CACNA2D1 PTPN13 FAT3 ZFPM2

1.78e-05186775cb1fc4b9140666b43415e21c9b434dc9b144e9d0
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

USP53 COL6A3 SGCD FAT3 ZFPM2

1.82e-0518777592d468dde81125d51daf7abd4703741abe1ab91c
ToppCellPericytes-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

TBX15 COL6A3 CACNA2D1 ACTG2 COX4I2

1.87e-05188775f16ff998393bf1954bbf10caab15173bdb104ac1
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

COL6A3 FAT3 ROR1 ACTG2 IRS1

1.97e-05190775d24af6af3271e34afab744352afd28be8a7cc5c3
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FAT3 ACTG2 IRS1 MTCL1 RRM1

1.97e-05190775e83fa8b711aa79a1767818474f1c193b674b1c31
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SGCD FAT3 ACTG2 ADCY5 ZFPM2

2.02e-0519177514057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

COL6A3 CACNA2D1 PTPN13 FAT3 ZFPM2

2.02e-0519177578c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

USP53 COL6A3 SGCD FAT3 ZFPM2

2.02e-051917756688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_2-SCMF|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

COL6A3 SUGCT SGCD IRS1 ZFPM2

2.07e-0519277567e845e513e76e820f55e2f0d15eb16f2944d05c
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

USP53 COL6A3 SGCD FAT3 ZFPM2

2.07e-0519277599ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

USP53 COL6A3 CACNA2D1 SGCD FAT3

2.12e-0519377599525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

USP53 COL6A3 CACNA2D1 SGCD FAT3

2.17e-05194775e93de9428c986b8943fc169258847c650cfab0e5
ToppCellControl-Fibroblasts-Intermediate_pathological_FB|Control / group, cell type (main and fine annotations)

COL6A3 CACNA2D1 SUGCT SGCD ZFPM2

2.17e-0519477503a269f75a481ea54aea8e6444605db8d6df493d
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

COL6A3 CACNA2D1 FAT3 ROR1 PCCA

2.17e-05194775b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL6A3 CACNA2D1 SGCD FAT3 ZFPM2

2.17e-0519477535f132cc38ac133be01834ed0946188aa0757eb4
ToppCellLA-02._Fibroblast_II|LA / Chamber and Cluster_Paper

USP53 COL6A3 CHD9 CATSPERB ZFPM2

2.17e-05194775234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCellCOVID-19-lung-Pericytes/_Smooth_Muscle|lung / Disease (COVID-19 only), tissue and cell type

PRUNE2 CACNA2D1 ACTG2 COX4I2 ADCY5

2.17e-051947755e1e0513a54ec4cf0b247ec85c9fbc68dfac1da3
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

COL6A3 CACNA2D1 FAT3 ROR1 PCCA

2.23e-051957750e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCellRA-02._Fibroblast_II|RA / Chamber and Cluster_Paper

USP53 COL6A3 CHD9 CATSPERB ZFPM2

2.23e-051957756a02ebbeb3199447ddce64d92d8809436e040eba
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 SGCD FAT3 ACTG2 ZFPM2

2.28e-051967751522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

COL6A3 CACNA2D1 SGCD FAT3 ROR1

2.28e-051967751450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 SGCD FAT3 ACTG2 ZFPM2

2.28e-051967751c8294014713684b50885e638668f2ce75f357f0
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PRUNE2 SGCD FAT3 ACTG2 ADCY5

2.28e-051967759830fb3da7a60f65ad463e9054bb77c06b025e4d
ToppCellnucseq-Mesenchymal-Fibroblastic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

USP53 COL6A3 SGCD FAT3 ZFPM2

2.28e-051967757d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TBX15 PRUNE2 COL6A3 ACTG2 ADCY5

2.34e-05197775cfb3dc4b401800e33c82cfc3baee69dbbd16ac8c
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PRUNE2 COL6A3 SUGCT SGCD ZFPM2

2.34e-051977750dd71e399f253787fa546a7e90c5373180b89ffd
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PRUNE2 SGCD FAT3 ACTG2 ADCY5

2.34e-05197775bf0520a94ebb1d2f94de9f526d17e0b0e8fe7052
ToppCellCOVID-19-Fibroblasts-Intermediate_pathological_FB|COVID-19 / group, cell type (main and fine annotations)

COL6A3 CACNA2D1 SUGCT SGCD ROR1

2.34e-05197775f1c8936986123a3151140c374fcd62d6705c530b
ToppCellTracheal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

PRUNE2 SGCD FAT3 ROR1 ACTG2

2.40e-05198775cbb63b255bdc92a557c5db1f08f7766ed9346607
ToppCellParenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PRUNE2 FAT3 TENM1 ACTG2 ADCY5

2.40e-05198775d1827e3707b929e3a3562989a0c11537d344e164
ToppCellnucseq-Mesenchymal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

USP53 COL6A3 SGCD FAT3 ZFPM2

2.40e-051987758f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCellFetal_29-31_weeks-Mesenchymal|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL6A3 CACNA2D1 SGCD FAT3 ZFPM2

2.40e-0519877521cf4d81386761d09d0f6829c01c198e5524176d
ToppCellMesenchymal|World / Lineage, Cell type, age group and donor

COL6A3 CACNA2D1 SGCD FAT3 ZFPM2

2.46e-051997754bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PRUNE2 COL6A3 ACTG2 IRS1 ZFPM2

2.46e-05199775e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCellTracheal-10x3prime_v2-Stromal-Myofibroblastic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

PRUNE2 SUGCT ACTG2 COX4I2 ADCY5

2.46e-05199775534dcfe8b65ad92bb8d749d1c7036ad4807e09cd
ToppCellTracheal-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TBX15 OR2B11 PTPN13 ROR1 ZFPM2

2.46e-051997759c2db0bb94cba71a3cc1827844da090e213e0258
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PRUNE2 ACTG2 IRS1 ADCY5 ZFPM2

2.52e-05200775f599e4b051ac3dad11ad437e98dc8ea6754cca53
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PRUNE2 SGCD FAT3 ACTG2 ADCY5

2.52e-05200775a66449b22b39dd6987fc2c3ed160d24564234ced
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TET2 DDX17 HELZ DTX3L HNRNPA2B1

2.52e-0520077512f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellBronchus_Control_(B.)-Stromal-TX-Fibroblasts-4|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

TBX15 COL6A3 SGCD ROR1 ZFPM2

2.52e-0520077554b18c92daaa3b3368c0c46134b0c27e10c8dbb0
ToppCellLPS_only-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_only / Treatment groups by lineage, cell group, cell type

PRUNE2 ACTG2 IRS1 MTCL1 ZFPM2

2.52e-05200775593bf6a7c557437db9a9249a5058a46014179ef6
ToppCellLPS_anti-TNF-Mesenchymal_myocytic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PRUNE2 COL6A3 ACTG2 IRS1 ADCY5

2.52e-0520077567dcbd86fbc79fd585d0793f979e4aac100326c9
ToppCellLPS_only-Mesenchymal_myocytic-Myofibroblastic|LPS_only / Treatment groups by lineage, cell group, cell type

PRUNE2 COL6A3 ACTG2 IRS1 ZFPM2

2.52e-0520077502cae2c296a13ad4cbb53bca7a86d64629d67d66
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

USP53 COL6A3 SGCD FAT3 ZFPM2

2.52e-05200775311fab076f2ceb258e3970eb21e39344b894042a
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL6A3 SUGCT SGCD TENM1 IRS1

2.52e-0520077558b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCellHippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3|Hippocampus / BrainAtlas - Mouse McCarroll V32

TBX15 SLC43A1 C16orf96 COX4I2

6.77e-05126774b0bc61be1d4ce8114077c524fedfdf89128bcf12
DiseaseAutistic behavior

CUX2 POU3F3 TET3

9.48e-078773C0856975
Diseaseobsessive-compulsive disorder, Tourette syndrome

HACE1 POU1F1 CAMTA1

4.25e-0526773EFO_0004242, EFO_0004895
DiseaseNeurodevelopmental Disorders

SPAST KCNQ2 ADCY5 ALG13

1.05e-0493774C1535926
Diseasecolon adenoma (is_marker_for)

TET2 AXIN2

1.40e-047772DOID:0050912 (is_marker_for)
DiseaseBMI-adjusted waist circumference, forced expiratory volume

CUX2 OTUD7B

2.39e-049772EFO_0004314, EFO_0007789
Diseaselong QT syndrome (implicated_via_orthology)

KCNH6 KCNQ2

2.98e-0410772DOID:2843 (implicated_via_orthology)
DiseaseHOMA-B

CUX2 ADCY5 ZFPM2

4.07e-0455773EFO_0004469
Diseasevascular endothelial growth factor measurement

ROR1 MTCL1 ZFPM2

4.29e-0456773EFO_0004762
Diseasegestational age

SUGCT CAMTA1 TET3 ADCY5

4.76e-04138774EFO_0005112
Diseaseoral squamous cell carcinoma (is_marker_for)

TET2 PTPN13 AXIN2

6.06e-0463773DOID:0050866 (is_marker_for)
Diseaseplatelet component distribution width

PRUNE2 KIF9 CATSPERB IRS1 CAMTA1 ADCY5 ZFPM2 TLX1

7.87e-04755778EFO_0007984
Diseaseresponse to acetylsalicylate

CACNA2D1 KIF9

7.88e-0416772GO_1903492
DiseaseMAJOR AFFECTIVE DISORDER 2

CUX2 KCNQ2

8.91e-0417772C1839839
Diseaseresponse to radiation, Urinary retention

COL6A3 CAMTA1

8.91e-0417772GO_0009314, HP_0000016
Diseasemuscular dystrophy (is_implicated_in)

COL6A3 SGCD

8.91e-0417772DOID:9884 (is_implicated_in)
DiseaseIntellectual Disability

CUX2 TCF20 POU3F3 TET3 CIC ALG13

1.12e-03447776C3714756
Diseasealcohol drinking

CUX2 FAT3 ROR1

1.26e-0381773EFO_0004329
Diseasehair color

TYR TET2 TCF20 SGCD AXIN2

1.34e-03311775EFO_0003924
Diseaselymphocyte count

TET2 OR2B11 UBAP2 SPAST CDC42SE2 ACSBG1 SGCD HELZ RRM1 ADCY5 ZFPM2

1.42e-0314647711EFO_0004587
DiseaseDystonia

COL6A3 KCNQ2 ADCY5

1.50e-0386773C0013421
Diseasesmoking status measurement, chronic obstructive pulmonary disease

TET2 MTCL1 ADCY5

1.60e-0388773EFO_0000341, EFO_0006527
Diseaseperipheral neuropathy, response to antimicrotubule agent

SUGCT ZFPM2

1.64e-0323772EFO_0003100, EFO_0005260
Diseaseresponse to antiviral drug, cirrhosis of liver

KCNQ2 MTCL1

1.79e-0324772EFO_0001422, EFO_0010123
Diseasefasting blood glucose measurement, HOMA-B, fasting blood insulin measurement

SGCD ADCY5

1.94e-0325772EFO_0004465, EFO_0004466, EFO_0004469
DiseaseIniencephaly

CECR2 RRM1

2.43e-0328772C0152234
DiseaseTethered Cord Syndrome

CECR2 RRM1

2.43e-0328772C0080218
DiseaseSpinal Cord Myelodysplasia

CECR2 RRM1

2.43e-0328772C0344479
DiseaseExencephaly

CECR2 RRM1

2.43e-0328772C0266453
DiseaseNeurenteric Cyst

CECR2 RRM1

2.43e-0328772C0027806
Diseaseglucose metabolism disease (implicated_via_orthology)

KCNH6 IRS1

2.43e-0328772DOID:4194 (implicated_via_orthology)
DiseaseAcrania

CECR2 RRM1

2.43e-0328772C0702169
DiseaseDiastematomyelia

CECR2 RRM1

2.43e-0328772C0011999
DiseaseSeizures

CUX2 HACE1 KCNQ2 TET3

2.57e-03218774C0036572
DiseaseCraniorachischisis

CECR2 RRM1

2.61e-0329772C0152426
Diseasemammographic density percentage

TBX15 TET3

2.61e-0329772EFO_0006502

Protein segments in the cluster

PeptideGeneStartEntry
GSGVPYGPINNMKNV

SUGCT

351

Q9HAC7
QTYGGGGLKAEMVSS

CAMTA1

496

Q9Y6Y1
KESQYGFTPGNGQMP

ALG13

711

Q9NP73
GLAPSLGIMNSTYNG

CATSPERB

81

Q9H7T0
AYATSTGGIVNKMVG

ASRGL1

181

Q7L266
NTAYMSNGGLGSLKV

AXIN2

206

Q9Y2T1
ANNVLSGGTTMYPGI

ACTG2

296

P63267
MSGSKSVSPPGYAAQ

ADCY5

1

O95622
SSLSGKMYSGSQAPG

CUX2

1021

O14529
KMYSGSQAPGGIQEI

CUX2

1026

O14529
LGQISGPSQDGSMYA

CECR2

731

Q9BXF3
NNRTSPGMAQKGYSE

MTCL1

1726

Q9Y4B5
VGNGGSKYSQEVMQS

OTUD7B

581

Q6GQQ9
GPMFKNTSVGLLYSG

MUC16

12581

Q8WXI7
LQYSPDMGKGSATFN

MUC16

14086

Q8WXI7
GPNMGGKSSYIKQVA

MSH3

896

P20585
AVMGYKPGSGVVTAS

LSG1

611

Q9H089
MGYGKSGQNAQGILT

ASAH2

121

Q9NR71
KGVNGSSQAPTSGKY

ZFPM2

1106

Q8WW38
SKGYSLLGPGSQNSM

KCNH6

756

Q9H252
YAANGMGPLKVLSGS

SLC43A1

541

O75387
QSKGGYGGGMPANVQ

CDC42SE2

61

Q9NRR3
MVQKSRNGGVYPGPS

KCNQ2

1

O43526
SSPSNGIDMGYNGNK

HACE1

336

Q8IYU2
GIDMGYNGNKTPRSQ

HACE1

341

Q8IYU2
NGTIMCYGQTGAGKT

KIF9

86

Q9HAQ2
AGGNMSIQFLGTVYK

PCCA

621

P05165
ELSNYICMGGKGPST

IRS1

461

P35568
MLTGVSGGAKYAQNG

HELZ

491

P42694
RPGSKTYVVTGNMGS

DSG1

386

Q02413
QIGQYGNGLKSGSMR

MORC2

96

Q9Y6X9
LVNMGSSQKTISYGG

OR2B11

86

Q5JQS5
SLKGQPSISGGMYEA

DNAH1

1881

Q9P2D7
AMKPPGAQGSQSTYT

CDK2AP2

61

O75956
MNNGTPESAYILQGG

CHD9

2236

Q3L8U1
QLVMGPAGSGKSTYC

GPN3

6

Q9UHW5
KVMGGYDFPGSNSNI

CAPN7

381

Q9Y6W3
SYLANMGGPSSLGTT

C16orf96

716

A6NNT2
TSYGIQKGNQPEGSM

DTX3L

601

Q8TDB6
NKSGPGAYESGIMVS

CACNA2D1

781

P54289
ISNMSYIGGTNQTGK

COL6A3

106

P12111
RGMKLYGNNGVSSTA

FAT3

236

Q8TDW7
YTSGTTGNPKGVMLS

ACSBG1

281

Q96GR2
AQTGTGKTLSYLMPG

DDX53

266

Q86TM3
MVGIAQTGSGKTLAY

DDX17

211

Q92841
DVNMGCPKQYSTKGG

DUS2

111

Q9NX74
CPKQYSTKGGMGAAL

DUS2

116

Q9NX74
QSKTKGYAGTPGFMA

GRK1

346

Q15835
LYSQPGGFTVNGMLS

POU3F3

221

P20264
AQTGTGKTLCYLMPG

DDX43

286

Q9NXZ2
GTTRGGGKMSPYTNC

COX4I2

26

Q96KJ9
NNAAGYSCGPGTLKM

PTPN13

2076

Q12923
YSCGPGTLKMNGKLS

PTPN13

2081

Q12923
STLGSQGQTGKLMYV

MED20

51

Q9H944
APLSQGSSGIMELYG

PRUNE2

376

Q8WUY3
SSQYKSSMALGPGAG

TMEM200A

356

Q86VY9
GNQPSTYGVMAGSLT

POU1F1

61

P28069
LPGNSKMEAYGGQLG

TBX15

456

Q96SF7
MTYPGNTGLLATKSN

TENM1

1631

Q9UKZ4
APSYSGLSMVSGVKQ

SPAST

266

Q9UBP0
GGLLYSQPSFTVNGM

POU3F2

186

P20265
LTQMVSGPASYSGPK

CIC

376

Q96RK0
GVPMQGQGTIGNYVS

SS18L1

161

O75177
GGNLGKVYQPGSMLS

USP53

11

Q70EK8
GMGITVFGNKSQKPY

ROR1

896

Q01973
GLPDMTGSVYNKTQT

UBAP2

1011

Q5T6F2
SQMGSTLPSGAGYQS

THRAP3

281

Q9Y2W1
SNYGPMKSGNFGGSR

HNRNPA2B1

311

P22626
YIAGTNGNSNGLVPM

RRM1

261

P23921
STMPGSVGPQVYKVG

SGCD

11

Q92629
IPIGTYGQMKNGSTP

TYR

151

P14679
VMSPSGGYTQLLQGA

TMEM86B

66

Q8N661
YMAGNKDPVTTGTPQ

TCF20

91

Q9UGU0
GQYSGGPSMSPKRTN

TET3

1436

O43151
TPYIVLSGSGKSMNA

SART1

781

O43290
PRGLTGMKNLGNSCY

USP20

141

Q9Y2K6
LGRSMSYSSQKAQPG

ZDHHC5

631

Q9C0B5
PLTGSYNVNMALAGG

TLX1

96

P31314
LNSTGMYVANTKPGG

UBR4

2321

Q5T4S7
TSKQYTGNSNMPGGL

TET2

601

Q6N021
TSGGSGYKNNGPGEM

ZCCHC12

321

Q6PEW1
YAGQKTSPGMTNVFS

VPS13D

2346

Q5THJ4