Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	PLC activating G protein-coupled glutamate receptor activity	GRM1 GRM5	1.47e-05	2	77	2	GO:0001639
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	GRM1 GRM5	8.76e-05	4	77	2	GO:0099583
GeneOntologyMolecularFunction	G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	GRM1 GRM5	1.46e-04	5	77	2	GO:0099530
GeneOntologyMolecularFunction	glutamate receptor activity	GRIN1 GRM1 GRM5	1.51e-04	27	77	3	GO:0008066
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate binding	PLEKHA4 JPH2 CLVS1	2.29e-04	31	77	3	GO:0080025
GeneOntologyMolecularFunction	G protein-coupled glutamate receptor activity	GRM1 GRM5	5.19e-04	9	77	2	GO:0098988
GeneOntologyMolecularFunction	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	GRM1 GRM5	5.19e-04	9	77	2	GO:0001640
Domain	-	CORO1A WDR4 DPH7 TLE2 NUP133 COP1 HERC1 WRAP53 TBL1XR1 DYNC1I1	9.55e-07	333	76	10	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	CORO1A WDR4 DPH7 TLE2 NUP133 COP1 HERC1 WRAP53 TBL1XR1 DYNC1I1	1.01e-06	335	76	10	IPR015943
Domain	WD40	CORO1A WDR4 DPH7 TLE2 COP1 HERC1 WRAP53 TBL1XR1 DYNC1I1	1.05e-06	259	76	9	PF00400
Domain	WD40	CORO1A WDR4 DPH7 TLE2 COP1 HERC1 WRAP53 TBL1XR1 DYNC1I1	1.39e-06	268	76	9	SM00320
Domain	WD40_repeat	CORO1A WDR4 DPH7 TLE2 COP1 HERC1 WRAP53 TBL1XR1 DYNC1I1	1.57e-06	272	76	9	IPR001680
Domain	WD_REPEATS_1	CORO1A WDR4 DPH7 TLE2 COP1 HERC1 WRAP53 TBL1XR1 DYNC1I1	1.88e-06	278	76	9	PS00678
Domain	WD_REPEATS_2	CORO1A WDR4 DPH7 TLE2 COP1 HERC1 WRAP53 TBL1XR1 DYNC1I1	1.93e-06	279	76	9	PS50082
Domain	WD_REPEATS_REGION	CORO1A WDR4 DPH7 TLE2 COP1 HERC1 WRAP53 TBL1XR1 DYNC1I1	1.93e-06	279	76	9	PS50294
Domain	WD40_repeat_dom	CORO1A WDR4 DPH7 TLE2 COP1 HERC1 WRAP53 TBL1XR1 DYNC1I1	3.23e-06	297	76	9	IPR017986
Domain	GPCR_3_mtglu_rcpt_5	GRM1 GRM5	1.63e-05	2	76	2	IPR000202
Domain	GluR_Homer-bdg	GRM1 GRM5	1.63e-05	2	76	2	PF10606
Domain	Metabotropic_Glu_rcpt_Homer-bd	GRM1 GRM5	1.63e-05	2	76	2	IPR019588
Domain	GPCR_3_mtglu_rcpt_1	GRM1 GRM5	1.63e-05	2	76	2	IPR001256
Domain	GluR_Homer-bdg	GRM1 GRM5	1.63e-05	2	76	2	SM01229
Domain	WD40_repeat_CS	CORO1A DPH7 TLE2 COP1 HERC1 TBL1XR1	5.50e-05	164	76	6	IPR019775
Domain	FN3	FNDC3B FNDC1 KIAA0319L FNDC3A MERTK SDK1	1.07e-04	185	76	6	SM00060
Domain	FN3_dom	FNDC3B FNDC1 KIAA0319L FNDC3A MERTK SDK1	2.08e-04	209	76	6	IPR003961
Domain	ARF	ARF1 ARF3 ARF6	2.19e-04	29	76	3	PS51417
Domain	Small_GTPase_ARF	ARF1 ARF3 ARF6	2.19e-04	29	76	3	IPR024156
Domain	Arf	ARF1 ARF3 ARF6	2.68e-04	31	76	3	PF00025
Domain	Small_GTPase_ARF/SAR	ARF1 ARF3 ARF6	3.24e-04	33	76	3	IPR006689
Domain	GPCR_3_mtglu_rcpt	GRM1 GRM5	4.50e-04	8	76	2	IPR000162
Domain	ANF_lig-bd_rcpt	GRIN1 GRM1 GRM5	4.55e-04	37	76	3	IPR001828
Domain	ANF_receptor	GRIN1 GRM1 GRM5	4.55e-04	37	76	3	PF01094
Domain	fn3	FNDC3B FNDC1 FNDC3A MERTK SDK1	5.19e-04	162	76	5	PF00041
Domain	Peripla_BP_I	GRIN1 GRM1 GRM5	5.33e-04	39	76	3	IPR028082
Domain	NCD3G	GRM1 GRM5	1.24e-03	13	76	2	PF07562
Domain	GPCR_3_9-Cys_dom	GRM1 GRM5	1.24e-03	13	76	2	IPR011500
Domain	FN3	FNDC3B FNDC1 FNDC3A MERTK SDK1	1.31e-03	199	76	5	PS50853
Domain	GPCR_3_CS	GRM1 GRM5	1.44e-03	14	76	2	IPR017979
Domain	GPCR_3	GRM1 GRM5	3.26e-03	21	76	2	IPR000337
Domain	7tm_3	GRM1 GRM5	3.58e-03	22	76	2	PF00003
Domain	G_PROTEIN_RECEP_F3_2	GRM1 GRM5	3.58e-03	22	76	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GRM1 GRM5	3.58e-03	22	76	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GRM1 GRM5	3.58e-03	22	76	2	PS00979
Domain	G_PROTEIN_RECEP_F3_4	GRM1 GRM5	3.58e-03	22	76	2	PS50259
Domain	GPCR_3_C	GRM1 GRM5	3.58e-03	22	76	2	IPR017978
Domain	Small_GTPase	RAB6C ARF1 ARF3 ARF6	4.12e-03	160	76	4	IPR001806
Domain	Small_GTP-bd_dom	RAB6C ARF1 ARF3 ARF6	4.80e-03	167	76	4	IPR005225
Pathway	SA_G1_AND_S_PHASES	E2F2 ARF1 ARF3	2.90e-05	15	58	3	M1529
Pubmed	ADP-ribosylation factor is functionally and physically associated with the Golgi complex.	ARF1 ARF3 ARF6	1.04e-07	5	77	3	2105501
Pubmed	GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.	ARF1 ARF3 ARF6	3.63e-07	7	77	3	11950392
Pubmed	Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells.	ARF1 ARF3 ARF6	5.80e-07	8	77	3	8195219
Pubmed	Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6).	ARF1 ARF3 ARF6	5.80e-07	8	77	3	8947846
Pubmed	Expression analysis of type I ARF small GTPases ARF1-3 during mouse brain development.	ARF1 ARF3 ARF6	5.80e-07	8	77	3	38227057
Pubmed	Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.	GRIN1 GRM1 GRM5	3.73e-06	14	77	3	21795692
Pubmed	Excitatory glutamate is essential for development and maintenance of the piloneural mechanoreceptor.	GRIN1 GRM1 GRM5	4.66e-06	15	77	3	22241839
Pubmed	Involvement of group I metabotropic glutamate receptors and glutamate transporters in the slow excitatory synaptic transmission in the spinal cord dorsal horn.	GRM1 GRM5	4.84e-06	2	77	2	18554818
Pubmed	Cyclic ADP ribose-dependent Ca2+ release by group I metabotropic glutamate receptors in acutely dissociated rat hippocampal neurons.	GRM1 GRM5	4.84e-06	2	77	2	22028929
Pubmed	Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin.	ARF1 ARF3	4.84e-06	2	77	2	1577740
Pubmed	Assignment of human ADP ribosylation factor (ARF) genes ARF1 and ARF3 to chromosomes 1q42 and 12q13, respectively.	ARF1 ARF3	4.84e-06	2	77	2	8661066
Pubmed	Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP.	GRM1 GRM5	4.84e-06	2	77	2	9185557
Pubmed	Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin.	ARF1 ARF3	4.84e-06	2	77	2	2474826
Pubmed	Group 1 metabotropic glutamate receptors 1 and 5 form a protein complex in mouse hippocampus and cortex.	GRM1 GRM5	4.84e-06	2	77	2	27392515
Pubmed	Genetic inactivation of mGlu5 receptor improves motor coordination in the Grm1crv4 mouse model of SCAR13 ataxia.	GRM1 GRM5	4.84e-06	2	77	2	28982591
Pubmed	Direct interaction enables cross-talk between ionotropic and group I metabotropic glutamate receptors.	GRIN1 GRM5	4.84e-06	2	77	2	18182392
Pubmed	Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc.	GRIN1 GRM1	4.84e-06	2	77	2	19597494
Pubmed	Arf family GTP loading is activated by, and generates, positive membrane curvature.	ARF1 ARF6	4.84e-06	2	77	2	18597672
Pubmed	Structure of the human ADP-ribosylation factor 1 complexed with GDP.	ARF1 ARF6	4.84e-06	2	77	2	7990966
Pubmed	mGluR₁,5 activation improves network asynchrony and GABAergic synapse attenuation in the amygdala: implication for anxiety-like behavior in DBA/2 mice.	GRM1 GRM5	4.84e-06	2	77	2	22681774
Pubmed	Selective induction of metabotropic glutamate receptor 1- and metabotropic glutamate receptor 5-dependent chemical long-term potentiation at oriens/alveus interneuron synapses of mouse hippocampus.	GRM1 GRM5	4.84e-06	2	77	2	18035501
Pubmed	Determination of group I metabotropic glutamate receptor subtypes involved in the frequency of epileptiform activity in vitro using mGluR1 and mGluR5 mutant mice.	GRM1 GRM5	4.84e-06	2	77	2	12623213
Pubmed	FNDC3A is required for adhesion between spermatids and Sertoli cells.	FNDC3B FNDC3A	4.84e-06	2	77	2	16904100
Pubmed	Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation.	GRM1 GRM5	4.84e-06	2	77	2	15184389
Pubmed	mGluR1,5 activation protects cortical astrocytes and GABAergic neurons from ischemia-induced impairment.	GRM1 GRM5	4.84e-06	2	77	2	23280324
Pubmed	Arf1 and Arf6 promote ventral actin structures formed by acute activation of protein kinase C and Src.	ARF1 ARF6	4.84e-06	2	77	2	24916416
Pubmed	Metabotropic glutamate receptors in the main olfactory bulb drive granule cell-mediated inhibition.	GRM1 GRM5	4.84e-06	2	77	2	17093122
Pubmed	Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.	GRM1 GRM5	4.84e-06	2	77	2	11591458
Pubmed	Symmetric signal transduction and negative allosteric modulation of heterodimeric mGlu1/5 receptors.	GRM1 GRM5	4.84e-06	2	77	2	33279506
Pubmed	p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins.	HERC1 ARF1	4.84e-06	2	77	2	8861955
Pubmed	Myristoylome profiling reveals a concerted mechanism of ARF GTPase deacylation by the bacterial protease IpaJ.	ARF1 ARF6	4.84e-06	2	77	2	25773595
Pubmed	Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation.	ARF1 ARF6	4.84e-06	2	77	2	33310872
Pubmed	ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway.	ARF1 ARF3	4.84e-06	2	77	2	22971977
Pubmed	ADP-ribosylation factors regulate the development of CT signaling in immature human enterocytes.	ARF1 ARF6	4.84e-06	2	77	2	19359423
Pubmed	Intra-endosomal pH-sensitive recruitment of the Arf-nucleotide exchange factor ARNO and Arf6 from cytoplasm to proximal tubule endosomes.	ARF1 ARF6	4.84e-06	2	77	2	11278939
Pubmed	Activation of NMDA receptors reduces metabotropic glutamate receptor-induced long-term depression in the nucleus accumbens via a CaMKII-dependent mechanism.	GRIN1 GRM5	4.84e-06	2	77	2	22947307
Pubmed	In-vivo genetic ablation of metabotropic glutamate receptor type 5 slows down disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis.	GRM1 GRM5	4.84e-06	2	77	2	31102766
Pubmed	ADP-ribosylation factors: a family of approximately 20-kDa guanine nucleotide-binding proteins that activate cholera toxin.	ARF1 ARF6	4.84e-06	2	77	2	7898460
Pubmed	mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor Learning.	GRM1 GRM5	4.84e-06	2	77	2	35805089
Pubmed	Corticostriatal LTP requires combined mGluR1 and mGluR5 activation.	GRM1 GRM5	4.84e-06	2	77	2	12559117
Pubmed	A phosphatidylinositol-3-kinase-dependent signal transition regulates ARF1 and ARF6 during Fcgamma receptor-mediated phagocytosis.	ARF1 ARF6	4.84e-06	2	77	2	16669702
Pubmed	Enhanced Function and Overexpression of Metabotropic Glutamate Receptors 1 and 5 in the Spinal Cord of the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis during Disease Progression.	GRM1 GRM5	4.84e-06	2	77	2	31540330
Pubmed	Differential distribution of group I metabotropic glutamate receptors in developing human cortex.	GRM1 GRM5	4.84e-06	2	77	2	20149785
Pubmed	Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2-/- Mice.	GRIN1 GRM1 GRM5	5.72e-06	16	77	3	30466882
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	IGSF8 HSDL2 MRC2 CLNS1A NUP133 SDF2L1 CTSZ ARF1 TFR2	8.60e-06	613	77	9	22268729
Pubmed	Calcineurin inhibitor protein (CAIN) attenuates Group I metabotropic glutamate receptor endocytosis and signaling.	GRM1 GRM5	1.45e-05	3	77	2	19717561
Pubmed	The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4.	ARF1 ARF6	1.45e-05	3	77	2	19644450
Pubmed	Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices.	GRM1 GRM5	1.45e-05	3	77	2	12364493
Pubmed	SIRT1 Activation Attenuates Bone Cancer Pain by Inhibiting mGluR1/5.	GRM1 GRM5	1.45e-05	3	77	2	31270711
Pubmed	Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome.	GRM1 GRM5	1.45e-05	3	77	2	20410124
Pubmed	The regulation of hippocampal LTP by the molecular switch, a form of metaplasticity, requires mGlu5 receptors.	GRM1 GRM5	1.45e-05	3	77	2	16024054
Pubmed	Selective interaction of ARF1 with the carboxy-terminal tail domain of the 5-HT2A receptor.	ARF1 ARF6	1.45e-05	3	77	2	14573774
Pubmed	EFA6 controls Arf1 and Arf6 activation through a negative feedback loop.	ARF1 ARF6	1.45e-05	3	77	2	25114232
Pubmed	Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming body and play important roles in cytokinesis.	ARF1 ARF3	1.45e-05	3	77	2	26330566
Pubmed	ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6.	ARF1 ARF6	1.45e-05	3	77	2	9417041
Pubmed	mGluR1 and mGluR5 Synergistically Control Cholinergic Synaptic Transmission in the Thalamic Reticular Nucleus.	GRM1 GRM5	1.45e-05	3	77	2	27466334
Pubmed	Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome.	GRM1 GRM5	1.45e-05	3	77	2	21571007
Pubmed	ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor.	ARF1 ARF6	1.45e-05	3	77	2	12799371
Pubmed	Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome.	GRM1 GRM5	1.45e-05	3	77	2	20534533
Pubmed	Role of the conserved NPxxY motif of the 5-HT2A receptor in determining selective interaction with isoforms of ADP-ribosylation factor (ARF).	ARF1 ARF6	1.45e-05	3	77	2	16545942
Pubmed	ADP-ribosylation factors 1 and 6 regulate Wnt/β-catenin signaling via control of LRP6 phosphorylation.	ARF1 ARF6	1.45e-05	3	77	2	22907437
Pubmed	ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus.	ARF1 ARF3	1.45e-05	3	77	2	23783033
Pubmed	Metabotropic glutamate receptors 1 and 5 differentially regulate bulbar dopaminergic cell function.	GRM1 GRM5	1.45e-05	3	77	2	20692242
Pubmed	Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice.	GRIN1 GRM5	1.45e-05	3	77	2	29062097
Pubmed	Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors.	ARF1 ARF3	1.45e-05	3	77	2	10623590
Pubmed	Secretion of soluble vascular endothelial growth factor receptor 1 (sVEGFR1/sFlt1) requires Arf1, Arf6, and Rab11 GTPases.	ARF1 ARF6	1.45e-05	3	77	2	22962618
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRIN1 GRM1 GRM5	2.04e-05	24	77	3	35746896
Pubmed	Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system.	GRM1 GRM5	2.89e-05	4	77	2	29079293
Pubmed	Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.	GRM1 GRM5	2.89e-05	4	77	2	15745950
Pubmed	Two distinct populations of ARF bound to Golgi membranes.	ARF3 ARF6	2.89e-05	4	77	2	8491770
Pubmed	The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis.	FNDC3B FNDC3A	2.89e-05	4	77	2	32966780
Pubmed	The arf6 GAP centaurin alpha-1 is a neuronal actin-binding protein which also functions via GAP-independent activity to regulate the actin cytoskeleton.	ARF1 ARF6	2.89e-05	4	77	2	15679100
Pubmed	Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin γ1 chain.	GRM1 GRM5	2.89e-05	4	77	2	20876210
Pubmed	Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.	GRM1 GRM5	2.89e-05	4	77	2	15254091
Pubmed	Elevated phospholipase D activity in H-Ras- but not K-Ras-transformed cells by the synergistic action of RalA and ARF6.	ARF1 ARF6	2.89e-05	4	77	2	12509462
Pubmed	Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR.	GRM1 GRM5	2.89e-05	4	77	2	18094233
Pubmed	Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation.	ARF1 ARF6	2.89e-05	4	77	2	10589680
Pubmed	The adaptor proteins p66Shc and Grb2 regulate the activation of the GTPases ARF1 and ARF6 in invasive breast cancer cells.	ARF1 ARF6	2.89e-05	4	77	2	24407288
Pubmed	Do transmembrane domain neuregulin 1 mutant mice exhibit a reliable sensorimotor gating deficit?	GRM1 GRM5	2.89e-05	4	77	2	21605597
Pubmed	Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes.	ARF1 ARF3	4.82e-05	5	77	2	9038142
Pubmed	A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration.	ARF1 ARF6	4.82e-05	5	77	2	10749932
Pubmed	ADP ribosylation factor 1 activity is required to recruit AP-1 to the major histocompatibility complex class I (MHC-I) cytoplasmic tail and disrupt MHC-I trafficking in HIV-1-infected primary T cells.	ARF1 ARF6	4.82e-05	5	77	2	21917951
Pubmed	A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization.	GRM1 GRM5	7.22e-05	6	77	2	23911326
Pubmed	Homer: a protein that selectively binds metabotropic glutamate receptors.	GRM1 GRM5	7.22e-05	6	77	2	9069287
Pubmed	Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer.	GRM1 GRM5	7.22e-05	6	77	2	11418862
Pubmed	Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy.	GRM1 GRM5	1.01e-04	7	77	2	25003238
Pubmed	Cellular and subcellular localization of EFA6C, a third member of the EFA6 family, in adult mouse Purkinje cells.	ARF1 ARF6	1.01e-04	7	77	2	15836626
Pubmed	Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion.	GRM1 GRM5	1.01e-04	7	77	2	9920659
Pubmed	Identification of a new Pyk2 target protein with Arf-GAP activity.	ARF1 ARF6	1.01e-04	7	77	2	10022920
Pubmed	Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.	GRM1 GRM5	1.01e-04	7	77	2	9808458
Pubmed	Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development.	ARF1 ARF6	1.01e-04	7	77	2	23012656
Pubmed	SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses.	ARF1 ARF6	1.01e-04	7	77	2	21198641
Pubmed	Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins.	GRM1 GRM5	1.34e-04	8	77	2	11850456
Pubmed	GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.	GRM1 GRM5	1.34e-04	8	77	2	9651375
Pubmed	The human immunodeficiency virus-1 protein transactivator of transcription up-regulates N-methyl-D-aspartate receptor function by acting at metabotropic glutamate receptor 1 receptors coexisting on human and rat brain noradrenergic neurones.	GRIN1 GRM1	1.34e-04	8	77	2	16489129
Pubmed	Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol.	ARF3 ARF6	1.34e-04	8	77	2	8355790
Pubmed	Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3.	ARF1 ARF6	1.34e-04	8	77	2	11926829
Pubmed	Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2.	HMBS TFR2	1.34e-04	8	77	2	7567998
Pubmed	Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior.	GRIN1 GRM5	1.34e-04	8	77	2	18606955
Pubmed	Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.	GRIN1 GRM1 GRM5	1.38e-04	45	77	3	25979088
Interaction	UBA52 interactions	FNDC3B S100A16 SMARCAL1 CLNS1A PLEKHA4 FNDC3A OCLN PNPLA5 ARF1 ARF6	6.22e-06	437	77	10	int:UBA52
GeneFamily	WD repeat domain containing	CORO1A WDR4 DPH7 TLE2 COP1 HERC1 WRAP53 TBL1XR1 DYNC1I1	8.73e-08	262	55	9	362
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	ARF1 ARF3 ARF6	1.13e-04	31	55	3	357
GeneFamily	Fibronectin type III domain containing	FNDC3B FNDC1 FNDC3A MERTK SDK1	1.24e-04	160	55	5	555
GeneFamily	Glutamate metabotropic receptors\|Protein phosphatase 1 regulatory subunits	GRM1 GRM5	2.51e-04	8	55	2	281
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	CSMD1 OCLN GRM1 GRM5	2.23e-03	181	55	4	694
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC1 MRC2 CPXM1 SYNDIG1 CSMD1 CREB3L1	8.56e-07	186	77	6	94d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCell	Mesenchymal_cells-Ng2+_MSCs\|World / Lineage and Cell class	S100A16 MRC2 TLE2 MERTK RGS3 CREB3L1	1.03e-06	192	77	6	0703b8ec6960ff975ee5a2737054db67cab016b5
ToppCell	Hippocampus-Neuronal\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ELAPOR1 GRIN1 HERC1 GRM5 DYNC1I1 ARF3	1.09e-06	194	77	6	8aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCSK2 DGKI HERC1 CSMD1 GRM5 DYNC1I1	1.23e-06	198	77	6	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	PCSK2 DGKI HERC1 CSMD1 GRM5 DYNC1I1	1.31e-06	200	77	6	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	3'-Adult-SmallIntestine-Epithelial-mature_enterocytic-Paneth\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLCO4C1 SMARCAL1 E2F2 ERMARD FABP2	9.12e-06	162	77	5	768a566e76923323c1f197f60bab472a8784490b
ToppCell	18-Distal-RBC-RBC\|Distal / Age, Tissue, Lineage and Cell class	CDK15 HMBS E2F2 ABCA7 TFR2	1.32e-05	175	77	5	7130b816e0c02309c161d8e9ad7cb4bc2469e251
ToppCell	18-Distal-RBC\|Distal / Age, Tissue, Lineage and Cell class	CDK15 HMBS E2F2 ABCA7 TFR2	1.32e-05	175	77	5	cc476b4244442418b8f21721a82a36209b556b36
ToppCell	Thalamus-Neuronal-Excitatory\|Thalamus / BrainAtlas - Mouse McCarroll V32	PCSK2 ELAPOR1 GRIN1 HERC1 ARF3	1.36e-05	176	77	5	d2bbf13d21fb7582d7e5f90cd61a4ebe1cfccd66
ToppCell	droplet-Spleen-nan-3m-Lymphocytic-plasma_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC3B MAN1C1 SDF2L1 FNDC3A NUDCD1	1.73e-05	185	77	5	ff95a45b7cb782961bb8f008b6b507af2d4cb8b7
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-EECs\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCSK2 FCSK ABCA7 SDK1 CDH17	1.73e-05	185	77	5	d42f6722a6771752cd744146a09e2ead9b7252bc
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC1 MRC2 CPXM1 SYNDIG1 CREB3L1	1.73e-05	185	77	5	785c55d39909fac74415f24427979691e7e694e6
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC1 MRC2 CPXM1 SYNDIG1 CREB3L1	1.73e-05	185	77	5	97a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FNDC3B COP1 DGKI PCNX1 CLVS1	2.12e-05	193	77	5	779276e775cb2492e8dd36436295a536084a6415
ToppCell	Posterior_cortex-Neuronal\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ELAPOR1 GRIN1 HERC1 GRM5 DYNC1I1	2.12e-05	193	77	5	b4989e3436e84dbec3789b46057e0f7a0ebf09d4
ToppCell	wk_08-11-Hematologic-Meg-ery-Definitive_erythroblast\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	HMBS E2F2 HERC1 ABCA7 TFR2	2.12e-05	193	77	5	be75abfdf5301cf33df8ee9ed92504d44fdf19a6
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPHX1 KIAA0319L ELAPOR1 SDK1 CREB3L1	2.23e-05	195	77	5	2a9a36df1dbc4eac77a8ddbe939ec8a8d6c41464
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPHX1 KIAA0319L ELAPOR1 SDK1 CREB3L1	2.23e-05	195	77	5	576142b4e75457c0973051bccc4163bd624496af
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPHX1 KIAA0319L ELAPOR1 SDK1 CREB3L1	2.23e-05	195	77	5	8f151066ad3ebd9661ea0b733f03c2ce1518f9ad
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCSK2 DGKI CSMD1 GRM5 DYNC1I1	2.28e-05	196	77	5	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Striatum-Neuronal-Excitatory\|Striatum / BrainAtlas - Mouse McCarroll V32	PCSK2 GRIN1 GRM5 ARF1 ARF3	2.28e-05	196	77	5	67400193ba469cf4d939e94f5ed94995e384bc07
ToppCell	10x3'2.3-week_12-13-Mesenchymal_osteo-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SGCB MRC2 RGS3 CREB3L1 DYNC1I1	2.34e-05	197	77	5	63b63c6b2f842adb87bc83222ff86796bd9b58f6
ToppCell	10x3'2.3-week_12-13-Mesenchymal_osteo\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SGCB MRC2 RGS3 CREB3L1 DYNC1I1	2.34e-05	197	77	5	fb50903b87498b400c8e16e6a561b6d9458e5d97
ToppCell	Fibroblasts-HLA-DRA_high_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	EPHX1 FNDC1 S100A16 MRC2 PLEKHA4	2.40e-05	198	77	5	e8c0fbf306fae13e97caa294d7c99a564bd97130
ToppCell	LPS_only\|World / Treatment groups by lineage, cell group, cell type	CORO1A HMBS IRF7 RGS3 ARF3	2.46e-05	199	77	5	852cf595c2255983cff9045f2bb746d4391cf5ba
ToppCell	3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	FNDC1 DGKI PCNX1 HERC1	8.85e-05	135	77	4	ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCell	COVID-19-kidney-Technical/muscle_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	CSMD1 GRM1 GRM5 CLVS1	1.20e-04	146	77	4	c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC2\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CORO1A HPGDS SDF2L1 CTSZ	1.47e-04	154	77	4	c663e9834be0b45389a862dc3c13a1f988a3e5ee
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CORO1A SLCO4C1 E2F2 DNAH6	1.66e-04	159	77	4	f7803f7b4e0379ae8256ec53110833bedee7db98
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CORO1A SLCO4C1 E2F2 DNAH6	1.66e-04	159	77	4	6e2d38e78d2ef7803e8bb154b5c788bf62a41045
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK2 JPH2 CSMD1 CTSZ	1.79e-04	162	77	4	c7114e24cb5525abb9780ca3d35dbcc4eabd4b64
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK2 JPH2 CSMD1 CTSZ	1.79e-04	162	77	4	f1851a173d3bcca2981d934161ec85d1cc0af5a2
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK2 JPH2 CSMD1 CTSZ	1.79e-04	162	77	4	5d902bb31e691aea9749617cc88303c2448f24b8
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m-Myeloid-macrophage\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CORO1A SLCO4C1 E2F2 DNAH6	1.83e-04	163	77	4	57f02f2b9ce940a2962bb57cd8d02eb67b6f44a3
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m-Myeloid\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CORO1A SLCO4C1 E2F2 DNAH6	1.83e-04	163	77	4	155ac52a34e0d55545aab8a3e4162fc4c387e697
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m-Myeloid-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CORO1A SLCO4C1 E2F2 DNAH6	1.83e-04	163	77	4	c132fb5b56186a10d33ae5ce17b2a7e670d52f79
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD8-Tem/emra_CD8\|GI_large-bowel / Manually curated celltypes from each tissue	SLCO4C1 S100A16 PRDM7 ARHGEF16	1.96e-04	166	77	4	13bef304ea3df8e8d2bc376a3287c78220a1b0c6
ToppCell	wk_20-22-Hematologic-Myeloid-Mast\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CDK15 HPGDS CARD14 RAB6C	1.96e-04	166	77	4	004ab6a1425d812c7ce572205875fd702d4a9659
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	ZNF713 MRC2 MERTK CREB3L1	2.01e-04	167	77	4	b5d15773be32cd277125fd3b4056a8fefaefa5ec
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|Myeloid_cells / Location, Cell class and cell subclass	FCSK SGCB ABCA7 CREB3L1	2.10e-04	169	77	4	dba8f5599aa21feef5b7fdfed2e3ab54748d80f7
ToppCell	Pericytes-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	JPH2 DGKI SYNDIG1 DYNC1I1	2.20e-04	171	77	4	bbc8d9fc83d37c9250345b1e76776610799de9ae
ToppCell	COVID-19-kidney-PEC\|kidney / Disease (COVID-19 only), tissue and cell type	LRP2 SYNDIG1 GRM5 SDK1	2.25e-04	172	77	4	36a96714a0eb6ac438648135336c9791881ddadb
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CDK15 CPXM1 CLVS1 CREB3L1	2.30e-04	173	77	4	ab6d3507301038f944ad59ccd848b5e6eeb76d04
ToppCell	Epithelial-Epithelial-C_(AT2)\|Epithelial / shred on cell class and cell subclass (v4)	SLCO4C1 ELAPOR1 LRP2 ARF6	2.30e-04	173	77	4	f57cbf5bd2a9e5db47b4919e9cd5e50781c1a990
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW10-Neuronal-GABAergic_neurons\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	SLCO4C1 PLEKHA4 DGKI TFR2	2.40e-04	175	77	4	d4ff1f197ad4086286e86817cbff24fa718293fc
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	PCSK2 SYNDIG1 GRM5 ARF3	2.40e-04	175	77	4	ff0789f5913c9f3c49159e40b1ec3d2ff175ec9f
ToppCell	COVID-19-lung-RBC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	HMBS E2F2 HERC1 TFR2	2.40e-04	175	77	4	4c35292ad2ac712ba7516f27dd6eac6ba8fdd163
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HPGDS DGKI GRM5 CLVS1	2.40e-04	175	77	4	f24b664b9056b5976bf2222e8013f15c09e049ad
ToppCell	facs-Marrow-B-cells-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX1 PCSK2 LRP2 CSMD1	2.40e-04	175	77	4	887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	PCSK2 SYNDIG1 GRM5 ARF3	2.40e-04	175	77	4	21f8f11a8b874d4f7c47931010a2535f2a5a3373
ToppCell	droplet-Spleen-SPLEEN-1m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF8 SGCB MAN1C1 IRF7	2.56e-04	178	77	4	742ee0cb8cb585a5e34bd5b20aebe9bb99756e0c
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMBS SDF2L1 E2F2 CTSZ	2.56e-04	178	77	4	1a578d16008a450c42e73a996247ffecdc2c43f0
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ELAPOR1 GRIN1 GRM5 ARF3	2.61e-04	179	77	4	a3922476f33d2e4137a12dbda21a1703dff79684
ToppCell	NS-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MAN1C1 DGKI GRIN1 ARHGEF16	2.61e-04	179	77	4	65a96bee7bc28f5bfc20f0fd92bcc0ab2eb5e06c
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MRC2 CPXM1 DGKI SYNDIG1	2.67e-04	180	77	4	935c091bbcd6d10b81dc4731779e5bd98205c99f
ToppCell	5'-Airway_Nasal-Mesenchymal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MRC2 CPXM1 DGKI SYNDIG1	2.67e-04	180	77	4	3dd384b7f3d9582b8fec9fe05100e466e6218b76
ToppCell	wk_15-18-Hematologic-Meg-ery-Definitive_erythroblast\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	HMBS E2F2 HERC1 TFR2	2.78e-04	182	77	4	93841f730ca1a735eaaf5f2ccbe5c45ab0e029d1
ToppCell	wk_20-22-Hematologic-Meg-ery-Definitive_erythroblast\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	HMBS E2F2 HERC1 TFR2	2.78e-04	182	77	4	0c77ef4556c1d1512ebe9077df858b28f9e38dd5
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CORO1A HPGDS SYNDIG1 CTSZ	2.78e-04	182	77	4	c6b3762ccec326f057819f75fa7fac0145fb7d54
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPHX1 KIAA0319L ELAPOR1 CREB3L1	2.78e-04	182	77	4	94e70746e35a3062015d4b83ee545f4f84f47420
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MRC2 CPXM1 DGKI SYNDIG1	2.84e-04	183	77	4	803376f5260de83c48d4f7301278d078a32b3e6e
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CORO1A MRC2 IRF7 NUDCD1	2.84e-04	183	77	4	bd78e5c2670e67b4363078e3ca5a5b7081d24b7e
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CORO1A MRC2 IRF7 NUDCD1	2.84e-04	183	77	4	d1bf3abf42eb9d7facf775becf1338d1faadd647
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MRC2 CPXM1 DGKI SYNDIG1	2.84e-04	183	77	4	6d98973098c6d20c5305bce6a83a549a7d8dbfba
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MRC2 CPXM1 DGKI SYNDIG1	2.84e-04	183	77	4	cc7f5a17b40e8d901885174922e5fa8877643071
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FNDC1 DPH7 MAN1C1 ERMARD	2.90e-04	184	77	4	a6dee97ee4ef9d89e11d17339e0dadaea1210ce5
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 CSMD1 GRM1 SDK1	2.90e-04	184	77	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	(2)_5-FU-(4)_COL2.3+_osteoblasts\|World / Stress and Cell class	FNDC3B MRC2 CPXM1 CREB3L1	2.90e-04	184	77	4	684d05340a3dfb8aa08b881516a37f9627a10448
ToppCell	facs-Lung-EPCAM-18m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO4C1 ELAPOR1 LRP2 ARHGEF16	2.90e-04	184	77	4	04bd8ab5808fcfa923aa4d0edf6a7f88b7980122
ToppCell	wk_15-18-Hematologic-Meg-ery-Cycling_definitive_erythroblast\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	HMBS E2F2 ABCA7 TFR2	2.90e-04	184	77	4	238eba615b4e04967d44ac7858a6673bdd7f67e9
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 CSMD1 GRM1 SDK1	2.90e-04	184	77	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 CSMD1 GRM1 SDK1	2.90e-04	184	77	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Kidney-nan-21m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC1 MRC2 CPXM1 SYNDIG1	2.90e-04	184	77	4	3bffadb0cb2e0d825bdb6cfc5d23f5436cbc3efd
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|368C / Donor, Lineage, Cell class and subclass (all cells)	DPH7 ELAPOR1 WRAP53 RAB6C	2.90e-04	184	77	4	d48807f9da48bdd015a54c606d2e2a311f181396
ToppCell	COVID-19_Moderate-HSPC\|World / disease group, cell group and cell class	CDK15 HPGDS CPXM1 TFR2	2.90e-04	184	77	4	ccc93babe1fcdeb66b78e1d8414357877a7c45bd
ToppCell	facs-Lung-EPCAM-18m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO4C1 ELAPOR1 LRP2 ARHGEF16	2.90e-04	184	77	4	e727bf110cb6a91a655c1865b0e93e51e2f9dda3
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC1 MRC2 CPXM1 CREB3L1	2.96e-04	185	77	4	3cd0686a14e734a0f243070ab939adcb4c454478
ToppCell	droplet-Kidney-nan-21m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC1 MRC2 CPXM1 SYNDIG1	2.96e-04	185	77	4	33cc0e9d8b54cb7408b51235f2a70e044ebae04d
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC1 MRC2 CPXM1 CREB3L1	2.96e-04	185	77	4	00258f458cbf6d36449db95528a6b5038d731d2d
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC1 MRC2 CPXM1 CREB3L1	2.96e-04	185	77	4	a94694e226856bc5b168464f52d76004145717a5
ToppCell	Fetal_29-31_weeks-Immune-enucleated_erythrocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HMBS E2F2 HERC1 TFR2	2.96e-04	185	77	4	e8f7da9641b6cf1db1093b4f301ce828fd3a529c
ToppCell	droplet-Kidney-nan-21m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC1 MRC2 CPXM1 SYNDIG1	2.96e-04	185	77	4	9954fc85b183c1cc45c3c24e3dadc7984ee6f649
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FNDC3B ELAPOR1 WRAP53 RAB6C	2.96e-04	185	77	4	7925519b855f76444a0b57382ce35d89457b0b14
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPHX1 ELAPOR1 SDK1 CREB3L1	2.96e-04	185	77	4	5dee5645240637e135677732a35fd416b37367d4
ToppCell	COVID-19_Moderate-HSPC\|COVID-19_Moderate / disease group, cell group and cell class	CDK15 HPGDS CPXM1 TFR2	2.96e-04	185	77	4	cacc6ab5f26f6c803894567fb838ea06eaa7efe5
ToppCell	(8)_CD34_progenitor\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	CDK15 HPGDS CPXM1 TFR2	3.02e-04	186	77	4	943c604a7cd873faf510096d094100512ba2d6bc
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK2 MAN1C1 ELAPOR1 CTSZ	3.02e-04	186	77	4	4bb54043f944a979db91bde9a86dd66f498c7658
ToppCell	Substantia_nigra-Neuronal\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ELAPOR1 GRIN1 GRM1 DYNC1I1	3.02e-04	186	77	4	3f889083fcffe516388e9b03a5e23af2010ced33
ToppCell	(8)_CD34_progenitor\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	CDK15 HPGDS CPXM1 TFR2	3.02e-04	186	77	4	e69a986b8618effd61875fda528a2e44aab11868
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CORO1A GRIN1 CSMD1 GRM5	3.02e-04	186	77	4	7278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCell	severe_influenza-RBC\|World / disease group, cell group and cell class (v2)	MRC2 HMBS E2F2 TFR2	3.09e-04	187	77	4	f846750575f318503d21ade30f5bfd2e1d4c84af
ToppCell	Club-club-14\|World / Class top	SLCO4C1 ELAPOR1 IRF7 CREB3L1	3.09e-04	187	77	4	4584de577d3736c89187e522497498e58d381c46
ToppCell	pdx-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	PCSK2 CPXM1 FNDC3A SDK1	3.09e-04	187	77	4	7e376831a11ee72ed87abcdac631ca46ae29c250
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CORO1A HPGDS SYNDIG1 CTSZ	3.15e-04	188	77	4	48dcbb424771a2f839d65b0c429ef01ad3479a4a
ToppCell	normal-na-Hematopoietic-progenitor_cell\|normal / PBMC cell types (v2) per disease, treatment status, and sex	HPGDS LRP2 CPXM1 TFR2	3.15e-04	188	77	4	013162466a3334b6967c0cb670c8577d809b1396
ToppCell	normal-na-Hematopoietic-progenitor_cell-female\|normal / PBMC cell types (v2) per disease, treatment status, and sex	HPGDS LRP2 CPXM1 TFR2	3.15e-04	188	77	4	be25371e6459504b5f0c9ece3a0fe8f80c7824ca
ToppCell	Influenza_Severe-RBC\|World / Disease group and Cell class	MRC2 HMBS E2F2 TFR2	3.15e-04	188	77	4	f0438e6a77ee1f0456cb65926685266fff470983
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Striatum / BrainAtlas - Mouse McCarroll V32	PCSK2 GRIN1 GRM5 ARF1	3.15e-04	188	77	4	e34ea7014c5a059a7db38f78bd903cf02616ddd3
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC2 PLEKHA4 CPXM1 CSMD1	3.21e-04	189	77	4	544d95df910f1b276995624509a7e41b219baca0
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	JPH2 CSMD1 SDK1 DYNC1I1	3.21e-04	189	77	4	7fbe855bfdb47d35e040b04a80fe4b729a3764e8
Disease	Galloway-Mowat syndrome (is_implicated_in)	WDR4 NUP133	6.69e-05	5	77	2	DOID:0080694 (is_implicated_in)
Disease	retinal degeneration (implicated_via_orthology)	RAB6D MERTK RAB6C	8.81e-05	33	77	3	DOID:8466 (implicated_via_orthology)
Disease	periventricular nodular heterotopia (is_implicated_in)	ERMARD ARF1	1.00e-04	6	77	2	DOID:0050454 (is_implicated_in)
Disease	Periventricular Nodular Heterotopia	ERMARD ARF1	1.40e-04	7	77	2	C1868720
Disease	Galloway Mowat syndrome	WDR4 NUP133	1.86e-04	8	77	2	C0795949
Disease	schizophrenia (implicated_via_orthology)	GRIN1 CSMD1 GRM5	7.58e-04	68	77	3	DOID:5419 (implicated_via_orthology)
Disease	filaggrin gene expression measurement	RGS3 CARD14	7.88e-04	16	77	2	EFO_0020899
Disease	Carcinomatosis	EPHX1 CORO1A MRC2 MERTK	8.88e-04	163	77	4	C0205699
Disease	Carcinoma, Spindle-Cell	EPHX1 CORO1A MRC2 MERTK	8.88e-04	163	77	4	C0205697
Disease	Undifferentiated carcinoma	EPHX1 CORO1A MRC2 MERTK	8.88e-04	163	77	4	C0205698
Disease	Anaplastic carcinoma	EPHX1 CORO1A MRC2 MERTK	8.88e-04	163	77	4	C0205696
Disease	methylcobalamin deficiency type cblE, overall survival, ovarian carcinoma, response to cisplatin	INTS4 SYNDIG1	8.91e-04	17	77	2	EFO_0000638, EFO_0001075, GO_0072718, MONDO_0009354
Disease	Carcinoma	EPHX1 CORO1A MRC2 MERTK	9.08e-04	164	77	4	C0007097
Disease	Attention Deficit Disorder	GRM1 GRM5	1.50e-03	22	77	2	C0041671
Disease	Minimal Brain Dysfunction	GRM1 GRM5	1.50e-03	22	77	2	C1321905
Disease	Epilepsy, Benign Psychomotor, Childhood	GRM1 GRM5	1.64e-03	23	77	2	C0393672
Disease	Epilepsy, Lateral Temporal	GRM1 GRM5	1.64e-03	23	77	2	C0393682
Disease	Uncinate Epilepsy	GRM1 GRM5	1.64e-03	23	77	2	C0014558
Disease	Epilepsy, Temporal Lobe	GRM1 GRM5	1.64e-03	23	77	2	C0014556
Disease	Attention deficit hyperactivity disorder	GRM1 GRM5	1.79e-03	24	77	2	C1263846
Disease	Psychotic Disorders	HPGDS GRIN1 CDH17	2.37e-03	101	77	3	C0033975
Disease	Strabismus	CSMD1 RGS3	2.61e-03	29	77	2	HP_0000486

Protein segments in the cluster

Peptide	Gene	Start	Entry
LASSDYEGTVILWDG	COP1	486	Q8NHY2
LFYDDGAGLWEDGRS	CREB3L1	426	Q96BA8
DNWGLDGYVSSGLER	CSMD1	3431	Q96PZ7
TLWRVGDYGSLSGRE	CTSZ	186	Q9UBR2
VDREADGGGDYLWRD	GJA10	516	Q969M2
YNLADGTELRGTWSL	FABP2	71	P12104
QEDGWLYGERLRDGE	ARHGEF16	661	Q5VV41
SGLEDGDLYDGAWCA	CPXM1	151	Q96SM3
TSGDGLYEGLDWLAN	ARF3	161	P61204
LRSWLISEGYATGPD	ARMC5	456	Q96C12
PDTIYSVDWSRDGGL	CORO1A	176	P31146
AGSGLARLGLSWYAD	ABCA7	1906	Q8IZY2
YLEDGTIGLRLWDTA	RAB6C	56	Q9H0N0
YLEDGTIGLRLWDTA	RAB6D	56	Q53S08
SDGLLLGGWERYTEV	RGS3	431	P49796
ELYSSGEFSSGRKWG	INTS4	341	Q96HW7
TLAWDRGYGTSLLGG	OCLN	86	Q16625
WVTLSDGTGRLYVIG	NUDCD1	126	Q96RS6
EGSIRYWPSLAGEDT	NUP133	181	Q8WUM0
SERSSGLRYEGEWLD	JPH2	306	Q9BR39
AGEFLLLGSDGWADR	GRM5	296	P41594
LLGSDGWADRYDVTD	GRM5	301	P41594
EGRYILNGGSEEWED	MERTK	926	Q12866
YLWTRDEGSPAAGEV	KIAA0319L	726	Q8IZA0
EGLPLGSDSLEYAWL	KIAA1109	901	Q2LD37
YSLGTGIRFDEWDEL	ELAPOR1	116	Q6UXG2
ELYTWGEGDFGRLGH	HERC1	531	Q15751
LDTYLGGREWLIGNS	HPGDS	131	O60760
GDSEGRIWVYDVGEL	DYNC1I1	596	O14576
DLLLGRWGNYSTGDC	PCNX1	1571	Q96RV3
GYSSTLWIGLNDLDT	MRC2	291	Q9UBG0
GLAGEEGSRRYSWVS	MRC2	1186	Q9UBG0
AIYLFELSGEDGGTW	HSDL2	331	Q6YN16
ARGKLYWSDQGTDSG	LRP2	1881	P98164
EWLLGEISSGCYEGL	IRF7	16	Q92985
GRLDSWERQGAGTYL	FCSK	441	Q8N0W3
TGEITYGGRVTDSWD	DNAH6	3746	Q9C0G6
WLAGGTVYRGETASL	IGSF8	446	Q969P0
TWTNTEFRYLEDGGL	EPHX1	331	P07099
ESRLSWLDGSGLGFS	CLNS1A	41	P54105
LYSSLAPDGWSDLDG	CARD14	966	Q9BXL6
DYLWGLEAGEGISDL	E2F2	411	Q14209
LLGATEYSSELDIWG	CDK15	271	Q96Q40
VYSGGDDGLLRGWDT	DPH7	211	Q9BTV6
DLARTLNWGGGYTDE	DGKI	466	O75912
GTDVTEYRLEWGGVE	FNDC3A	786	Q9Y2H6
DSSGADISEYRLEWG	FNDC3B	791	Q53EP0
DTFYSIGDSWGRGED	FNDC1	1816	Q4ZHG4
TSGDGLYEGLDWLSN	ARF1	161	P84077
GGLTYIAEWRGGILD	MAN1C1	431	Q9NR34
TESEQGLDYWGSVRL	ERMARD	56	Q5T6L9
LYLTGGVWSLDGSDS	HMBS	276	P08397
GSDGWADRDEVIEGY	GRM1	316	Q13255
LDISYSLRGDTRGWL	CDH17	596	Q12864
SLLISQTWSGDIGDY	SDK1	631	Q7Z5N4
WTGYRGGLDTKNDTT	GARNL3	246	Q5VVW2
GRSLGLYAWDDGSPL	WRAP53	346	Q9BUR4
IILYSEGVLRSWGDG	SYNDIG1	91	Q9H7V2
GLLAGGRGDNWYSED	RIC8B	456	Q9NVN3
RVWDTYSGLEQELGT	PLEKHA4	446	Q9H4M7
RLWYDMLGVSEDGSG	TAF1L	366	Q8IZX4
EEGRWNLSFSGAGYL	PNPLA5	6	Q7Z6Z6
WSGDEYGQELGIRSS	PRDM7	356	Q9NQW5
GWDYSGSSNLGELKL	SMARCAL1	621	Q9NZC9
LGRDEDSWGLSYTGL	SPSB3	186	Q6PJ21
SSSGDQLGSGDWVRY	SGCB	271	Q16585
SGELLWSSEYVRGLG	URB1	1171	O60287
LDWNSEGTLLATGSY	TBL1XR1	231	Q9BZK7
ATSGDGLYEGLTWLT	ARF6	156	P62330
GTWARTLLGPDYSDE	CLVS1	281	Q8IUQ0
DDANSYWRIRGGSEG	SDF2L1	76	Q9HCN8
RSLSLSEFEEGSYGW	SLCO4C1	76	Q6ZQN7
DGRISFDEYWTLIGG	S100A16	71	Q96FQ6
SSSGDGTLRLWEYRS	WDR4	206	P57081
WESLGEAYLSRGGYT	TTC37	601	Q6PGP7
ERLAGDSFWYSILGG	ZNF713	131	Q8N859
DISDYGTRLWTGGLD	TLE2	596	Q04725
FGSVGSTEWLEGYLS	TFR2	481	Q9UP52
LADSGYDVWLGNSRG	LIPK	106	Q5VXJ0
GEDARGTWTLELGFV	PCSK2	561	P16519
TGSGYVWLVGEREIS	GRIN1	241	Q05586