Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA replication origin binding

MCM2 ORC3

2.66e-0418272GO:0003688
GeneOntologyCellularComponentorigin recognition complex

MCM2 ORC3

4.48e-058272GO:0000808
GeneOntologyCellularComponentnuclear origin of replication recognition complex

MCM2 ORC3

4.48e-058272GO:0005664
GeneOntologyCellularComponentDNA replication preinitiation complex

MCM2 ORC3

1.24e-0413272GO:0031261
DomainABC_TRANSPORTER_2

ABCA13 ABCC10

1.87e-0348252PS50893
DomainABC_tran

ABCA13 ABCC10

1.87e-0348252PF00005
DomainABC_TRANSPORTER_1

ABCA13 ABCC10

1.95e-0349252PS00211
DomainABC_transporter-like

ABCA13 ABCC10

2.03e-0350252IPR003439
DomainLRR_6

LRRC31 NLRP8

2.45e-0355252PF13516
DomainP-loop_NTPase

MCM2 KIF6 ABCA13 ABCC10 NLRP8

4.75e-03848255IPR027417
DomainAAA+_ATPase

ABCA13 ABCC10

1.58e-02144252IPR003593
DomainAAA

ABCA13 ABCC10

1.58e-02144252SM00382
Domain-

MCM2 ABCA13 ABCC10 NLRP8

1.64e-027462543.40.50.300
PathwayBIOCARTA_MCM_PATHWAY

MCM2 ORC3

1.83e-0418162M6682
PathwayKEGG_MEDICUS_REFERENCE_DNA_REPLICATION_LICENSING

MCM2 ORC3

3.29e-0424162M47857
PathwayKEGG_MEDICUS_REFERENCE_PRE_IC_FORMATION

MCM2 ORC3

4.17e-0427162M47858
PathwayREACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX

MCM2 ORC3

5.87e-0432162MM15368
PathwayREACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX

MCM2 ORC3

6.25e-0433162M9694
PathwayREACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS

MCM2 ORC3

7.44e-0436162MM14687
PathwayREACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS

MCM2 ORC3

7.86e-0437162M11153
PathwayWP_DNA_REPLICATION

MCM2 ORC3

1.01e-0342162M39335
PathwayKEGG_ABC_TRANSPORTERS

ABCA13 ABCC10

1.11e-0344162M11911
Pubmed

The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells.

MCM2 ORC3

6.06e-051527210436018
Pubmed

The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase.

MCM2 ORC3

6.92e-051627211095689
Pubmed

DNA replication in eukaryotic cells.

MCM2 ORC3

8.81e-051827212045100
Pubmed

Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures.

MCM2 ORC3

9.84e-051927215226314
Pubmed

Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.

MCM2 ORC3

1.09e-042027212614612
Pubmed

A multiprotein complex necessary for both transcription and DNA replication at the β-globin locus.

MCM2 ORC3

1.21e-042127220808282
Pubmed

DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system.

MCM2 ORC3

1.33e-042227215707391
Pubmed

Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.

MCM2 ORC3

1.86e-042627211931757
Pubmed

Self-assembling protein microarrays.

MCM2 ORC3

2.49e-043027215232106
Pubmed

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.

MCM2 ORC3

3.21e-043427212791985
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ROCK1 AFAP1L2

1.40e-02206162682
CoexpressionAtlasDevelopingGonad_P2_ovary_emap-30224_k-means-cluster#4_top-relative-expression-ranked_1000

BNC1 ROCK1 TNFRSF19 SNX16

4.20e-05168254gudmap_developingGonad_P2_ovary_1000_k4
CoexpressionAtlasDevelopingGonad_P2_ovary_emap-30224_top-relative-expression-ranked_1000

GMEB1 BNC1 ROCK1 TNFRSF19 SNX16 LRRC31

2.19e-04770256gudmap_developingGonad_P2_ovary_1000
CoexpressionAtlasDevelopingGonad_e14.5_ ovary_emap-6699_top-relative-expression-ranked_1000

GMEB1 BNC1 ROCK1 TNFRSF19 SNX16 HUWE1

2.28e-04776256gudmap_developingGonad_e14.5_ ovary_1000
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_top-relative-expression-ranked_1000

GMEB1 BNC1 ROCK1 TNFRSF19 SNX16 LRRC31

2.31e-04778256gudmap_developingGonad_e18.5_ovary_1000
CoexpressionAtlasDevelopingGonad_e11.5_ovary + mesonephros_emap-3226_k-means-cluster#5_top-relative-expression-ranked_1000

BNC1 ROCK1 SNX16

2.50e-04105253gudmap_developingGonad_e11.5_ovary + mesonephros_k5_1000
ToppCellILEUM-non-inflamed-(3)_MNP-(3)_moDC|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MCM2 HPS5 GOLGB1

7.33e-05135273b7a792a7c0c22d8b703509f134115f0e394d7de0
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DIPK1B KIF6 ABCA13

1.17e-0415827335f3082109a5930b89d14db3c8fa93148d3a5dd4
ToppCellfacs-Heart-RV-24m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIPK1B TNFRSF19 KNSTRN

1.35e-0416627316d42eda958b2a6f9d598e9b4b967505dee426ef
ToppCellfacs-Heart-RV-24m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIPK1B TNFRSF19 KNSTRN

1.35e-0416627308d7db4ff1c9c9cea3a36a87b8690838e79d4e0e
ToppCelldroplet-Lung-nan-21m-Lymphocytic-Proliferating_NK|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIPK1B MCM2 CDIN1

1.35e-0416627321ba5fd755c0fb31ada42a1b5d60bede0153323d
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D122|Adult / Lineage, Cell type, age group and donor

DIPK1B ANO2 AFAP1L2

1.40e-041682738c3e1e45b422813bcdfa4273b1167db649a312f5
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DIPK1B ANO2 AFAP1L2

1.48e-041712731597459c971d6befa991d59dc66b41b6a522f797
ToppCellP03-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DIPK1B TNFRSF19 KNSTRN

1.66e-041782737975bf0a3146ee0efa4f547af5977e6bf0ba71fd
ToppCelldroplet-Spleen-nan-3m-Lymphocytic-immature_NKT_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIPK1B MCM2 KNSTRN

1.69e-0417927354621d2b3a66e62aa76b7e444118878ed97c1e02
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MCM2 AFAP1L2 KNSTRN

1.72e-0418027340d4838a0ccb10d5e49266bc8a0037d27b75ccc2
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

DIPK1B ANO2 AFAP1L2

1.86e-04185273a7ae76058b2082020cadec49d63b9f4e24d21734
ToppCellE15.5-Epithelial-airway_epithelial_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

STX19 ROCK1 TNFRSF19

1.89e-04186273bb2c7af3b1d8478c49a8626dbfd6c92c5e7adc4a
ToppCellAdult-Endothelial-endothelial_cell_of_artery|Adult / Lineage, Cell type, age group and donor

DIPK1B ANO2 AFAP1L2

1.89e-041862732d1c4ea2e401db89971582ee54618a8b0c81b8ac
ToppCellE15.5-Epithelial-airway_epithelial_cell-club_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

STX19 ROCK1 TNFRSF19

1.89e-0418627386c809b99088d3d6c8f87785797c4beefdcddbe7
ToppCellILEUM-inflamed-(3)_MNP-(3)_moDC|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MCM2 ROCK1 GOLGB1

1.92e-041872730099def970fbc828756fbf853eca2ce77b8cd342
ToppCellfacs-Lung-24m-Hematologic-myeloid-leukocyte|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DIPK1B KNSTRN ABCC10

1.95e-0418827361b6047affa18c5e71210fcce449e2bbe7cf141b
ToppCellfacs-Lung-24m-Hematologic-myeloid-leukocyte-proliferating_myeloid_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DIPK1B KNSTRN ABCC10

1.95e-04188273797ce39602f0f78081eb44a21da0d9443f7fd9cf
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma|TCGA-Lung / Sample_Type by Project: Shred V9

BNC1 MCM2 CDIN1

1.98e-04189273aa4f7d7a5196e5ae481ebc2549de8e3f0ef6e6be
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery|Children_(3_yrs) / Lineage, Cell type, age group and donor

DIPK1B ANO2 AFAP1L2

2.01e-04190273f6c38d197fd9d69a4f97cb2e72cd4747984c1a86
ToppCellSmart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ROCK1 CCDC88B ABCA13

2.04e-04191273d4f77c73311d1149466bbfe4adbd6a301946ec90
ToppCellfacs-Marrow-KLS-3m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIPK1B MCM2 PUS7

2.08e-0419227303dcd9405d3d76fc7455066ba5d83c09cd17072d
ToppCellSmart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ROCK1 CCDC88B ABCA13

2.11e-04193273e1855cff9a6bcfda9188b9fdf6c9d698405da990
ToppCellfacs-Marrow-KLS-18m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIPK1B MCM2 PUS7

2.14e-04194273c9ebdcc2ea600975dade68a41fa65d1f8a5a5926
ToppCellParenchymal-NucSeq-Immune_Myeloid-Myeloid|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DIPK1B AFAP1L2 NLRP8

2.17e-04195273027075e9c62b5754a014a9d1393e1b0f5ae42e41
ToppCellParenchymal-NucSeq-Immune_Myeloid-Myeloid-Megakaryocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DIPK1B AFAP1L2 NLRP8

2.17e-041952731bcc0c8b1281396b1433ce5a2ec8681de47ce9ad
ToppCellCV-Moderate-6|CV / Virus stimulation, Condition and Cluster

ROCK1 HUWE1 GOLGB1

2.20e-041962737bced0cc2112697593c478fa291b8ed3941fb811
ToppCellTracheal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DIPK1B ANO2 AFAP1L2

2.27e-04198273f88198e11e835ad53d339c312f8f7b7b0b5c02d3
ToppCell(05)_Secretory-(2)_GFP_FOXI1|(05)_Secretory / shred by cell type by condition

ROCK1 HPS5 GOLGB1

2.31e-04199273d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCell(10)_Ciliated-(2)_GFP_FOXI1|(10)_Ciliated / shred by cell type by condition

ROCK1 HPS5 GOLGB1

2.31e-0419927361b1ed2db71b96157b92b7535d1955a4033098da
ToppCell(04)_Interm._basal>secr.-(2)_GFP_FOXI1|(04)_Interm._basal>secr. / shred by cell type by condition

ROCK1 HPS5 GOLGB1

2.31e-0419927353ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

ROCK1 HPS5 GOLGB1

2.31e-04199273fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

ROCK1 HPS5 GOLGB1

2.31e-04199273c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BNC1 AFAP1L2 CDIN1

2.31e-041992734217b9e66c5374461e84bdb893ab650f148286c8
ToppCellParenchymal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

DIPK1B MCM2 PUS7

2.34e-04200273a8b59e6fe04271fef61db911a286b5c48438bb84
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

ROCK1 GOLGB1

7.18e-044992GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_CHROMATIN
ComputationalGenes in the cancer module 57.

MCM2 ORC3

9.37e-045692MODULE_57
ComputationalCell cycle (expression cluster).

MCM2 HUWE1 KNSTRN

1.08e-0326293MODULE_54
Diseasecolorectal cancer, overall survival

TNFRSF19 CDIN1

2.76e-0429252EFO_0000638, MONDO_0005575
Diseasephysical activity

ANO2 NLRP8

2.52e-0388252EFO_0003940
DiseaseSquamous cell carcinoma

AFAP1L2 KNSTRN

4.93e-03124252C0007137
Diseaseglucagon measurement

BNC1 NLRP8

7.50e-03154252EFO_0008463
Diseaseserum urea measurement

TMEM266 ABCC10

1.18e-02195252EFO_0009795
Diseasecortical thickness

BNC1 ANO2 KIF6 ABCC10

1.35e-021113254EFO_0004840
Diseasehair colour measurement

BNC1 SNX16 HPS5

1.47e-02615253EFO_0007822

Protein segments in the cluster

PeptideGeneStartEntry
LKTRALQLEEELFQL

CCDC88B

941

A6NC98
LLDRLFSVLKQDEVL

BNC1

111

Q01954
ALEQLLTELDDFLKI

AFAP1L2

6

Q8N4X5
KQLLIIDEDFRISLF

ABCA13

1066

Q86UQ4
EQTFEERLILKAFLL

ANO2

616

Q9NQ90
DLIFIEKIQRLLTNL

CCDC180

1111

Q9P1Z9
LQRNEFLLLLSLQEK

DIPK1B

201

Q5VUD6
RDNNELLLFILKQLV

MCM2

826

P49736
LLEAKVSLDRIQLFL

ABCC10

561

Q5T3U5
LYTLTDLERQLEEQK

GMEB1

336

Q9Y692
EELQRFKQLLLTELS

NLRP8

51

Q86W28
NDLISQLEELILKFE

HPS5

411

Q9UPZ3
NVRFLKELIELDISL

LRRC31

476

Q6UY01
ELLQLEKLITSFLED

KIF6

391

Q6ZMV9
KRLISIFTEQELELL

HUWE1

4236

Q7Z6Z7
EVLLRDLLLEKNLSF

CDIN1

166

Q9Y2V0
ERYLKEETQLLLENL

ORC3

391

Q9UBD5
RELSLTKEEELLFLQ

POLR3D

256

P05423
LLETLQEELKLFNET

KNSTRN

251

Q9Y448
LTAEEKQRLEELQLF

PUS7

171

Q96PZ0
IKDLRDLFIQISLLV

STX19

226

Q8N4C7
SELSELELLSQIKIF

TRIM75

241

A6NK02
INTLLEAKRLLEFEL

ROCK1

811

Q13464
LLEQEKTFFTLLVLL

TNFRSF19

6

Q9NS68
ETLEETNYRLQKELL

SNX16

231

P57768
TLELLIDIKLLQFSS

TMEM266

116

Q2M3C6
LERLKSQILELELNF

GOLGB1

686

Q14789