Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	protein kinase CK2 complex	CSNK2A1 CSNK2A3	1.12e-04	4	91	2	GO:0005956
Domain	ARM-type_fold	HIP1 MROH1 PIK3C2B CIP2A HEATR9 TOGARAM1 PRKDC ODAD2 ARMCX2 ARMCX1	4.85e-06	339	89	10	IPR016024
Domain	-	MROH1 CIP2A HEATR9 TOGARAM1 PRKDC ODAD2 ARMCX2 ARMCX1	1.09e-05	222	89	8	1.25.10.10
Domain	ARM-like	MROH1 CIP2A HEATR9 TOGARAM1 PRKDC ODAD2 ARMCX2 ARMCX1	4.42e-05	270	89	8	IPR011989
Domain	HEAT	MROH1 TOGARAM1 PRKDC ODAD2	1.68e-04	58	89	4	IPR000357
Domain	HEAT_REPEAT	MROH1 TOGARAM1 PRKDC ODAD2	3.47e-04	70	89	4	PS50077
Domain	ARM_REPEAT	ODAD2 ARMCX2 ARMCX1	9.10e-04	40	89	3	PS50176
Domain	ARM	ODAD2 ARMCX2 ARMCX1	9.10e-04	40	89	3	SM00185
Domain	ARM-rpt_dom	ARMCX2 ARMCX1	1.20e-03	11	89	2	IPR006911
Domain	Arm_2	ARMCX2 ARMCX1	1.20e-03	11	89	2	PF04826
Domain	KH_dom_type_1	KHDRBS1 EXOSC3 HDLBP	1.20e-03	44	89	3	IPR004088
Domain	Armadillo	ODAD2 ARMCX2 ARMCX1	1.46e-03	47	89	3	IPR000225
Domain	PI3/4_kinase_CS	PIK3C2B PRKDC	2.26e-03	15	89	2	IPR018936
Domain	-	PIK3C2B PRKDC	2.58e-03	16	89	2	1.10.1070.11
Domain	PI3Kc	PIK3C2B PRKDC	2.58e-03	16	89	2	SM00146
Domain	PI3/4_kinase_cat_dom	PIK3C2B PRKDC	3.27e-03	18	89	2	IPR000403
Domain	PI3_PI4_kinase	PIK3C2B PRKDC	3.27e-03	18	89	2	PF00454
Domain	PI3_4_KINASE_3	PIK3C2B PRKDC	3.27e-03	18	89	2	PS50290
Domain	PI3_4_KINASE_1	PIK3C2B PRKDC	3.27e-03	18	89	2	PS00915
Domain	PI3_4_KINASE_2	PIK3C2B PRKDC	3.27e-03	18	89	2	PS00916
Domain	AAA+_ATPase	ABCC3 CFTR ASCC3 RAD17	4.99e-03	144	89	4	IPR003593
Domain	AAA	ABCC3 CFTR ASCC3 RAD17	4.99e-03	144	89	4	SM00382
Domain	Actinin_actin-bd_CS	SYNE1 SPTB	5.32e-03	23	89	2	IPR001589
Domain	Spectrin	SYNE1 SPTB	5.32e-03	23	89	2	PF00435
Domain	ACTININ_2	SYNE1 SPTB	5.32e-03	23	89	2	PS00020
Domain	ACTININ_1	SYNE1 SPTB	5.32e-03	23	89	2	PS00019
Domain	ABC_membrane	ABCC3 CFTR	5.79e-03	24	89	2	PF00664
Pubmed	Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.	HIP1 FAF2 KHDRBS1 CFTR PRDX1 PSMB6 TJP2 PPP1R18 PRKDC ALPG HDLBP	6.40e-08	488	91	11	31324722
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	PTPN3 KHDRBS1 CENPF CSNK2A1 PRDX1 EXOSC3 TJP2 PPP1R18 POLR1B PRKDC ASCC3 PATJ SNRPA1 NOP2 HDLBP	9.02e-07	1257	91	15	36526897
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	FAF2 CENPB CEP85L CSNK2A1 PSMB6 TJP2 POLR1B ASCC3 SNRPA1 GPT2 VARS1 USP19 RAD17	2.17e-06	1005	91	13	19615732
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	KMT2D KHDRBS1 CSNK2A1 PRDX1 TJP2 PRKDC PARP14 SNRPA1 NOP2 VARS1 HDLBP	2.59e-06	711	91	11	33022573
Pubmed	UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts.	CSNK2A1 ANTXR1 PRKDC	2.82e-06	11	91	3	11709713
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	CENPB PRDX1 POLR1B PRKDC ASCC3 PARP14 SNRPA1 NOP2	3.23e-06	340	91	8	29478914
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	EDF1 HIP1 FAF2 CENPB CIP2A PRDX1 PSMB6 EXOSC3 TJP2 PPP1R18 PRKDC ASCC3 SNRPA1 NOP2 SNX19	4.77e-06	1440	91	15	30833792
Pubmed	mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells.	MAP1A SPTB PSMB6 RAD17 HDLBP	6.15e-06	98	91	5	34943047
Pubmed	Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2.	CSNK2A1 CSNK2A3	6.77e-06	2	91	2	14646071
Pubmed	Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit.	CSNK2A1 CSNK2A3	6.77e-06	2	91	2	12860116
Pubmed	Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax.	GPD1 KMT2D	6.77e-06	2	91	2	9247308
Pubmed	Using genomewide mutagenesis screens to identify the genes required for neural tube closure in the mouse.	TBC1D32 C2CD3	6.77e-06	2	91	2	15971254
Pubmed	Casein kinase 2 promotes interaction between Rad17 and the 9-1-1 complex through constitutive phosphorylation of the C-terminal tail of human Rad17.	CSNK2A1 RAD17	6.77e-06	2	91	2	29902452
Pubmed	Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer.	ABCC3 ERBB2	6.77e-06	2	91	2	18593940
Pubmed	Assignment of casein kinase 2 alpha sequences to two different human chromosomes.	CSNK2A1 CSNK2A3	6.77e-06	2	91	2	1577469
Pubmed	Function of erbB receptors and DNA-PKcs on phosphorylation of cytoplasmic and nuclear Akt at S473 induced by erbB1 ligand and ionizing radiation.	ERBB2 PRKDC	6.77e-06	2	91	2	21723633
Pubmed	Phosphorylation of cystic fibrosis transmembrane conductance regulator (CFTR) serine-511 by the combined action of tyrosine kinases and CK2: the implication of tyrosine-512 and phenylalanine-508.	CSNK2A1 CFTR	6.77e-06	2	91	2	24178769
Pubmed	ARMCX Family Gene Expression Analysis and Potential Prognostic Biomarkers for Prediction of Clinical Outcome in Patients with Gastric Carcinoma.	ARMCX2 ARMCX1	6.77e-06	2	91	2	32685472
Pubmed	Molecular cloning of the human casein kinase II alpha subunit.	CSNK2A1 CSNK2A3	6.77e-06	2	91	2	2752008
Pubmed	Structure and sequence of an intronless gene for human casein kinase II-alpha subunit.	CSNK2A1 CSNK2A3	6.77e-06	2	91	2	8420794
Pubmed	Casein kinase 2 associates with initiation-competent RNA polymerase I and has multiple roles in ribosomal DNA transcription.	CSNK2A1 POLR1B	6.77e-06	2	91	2	16880508
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	FAF2 KHDRBS1 CIP2A PRKDC ASCC3 SNRPA1 CSNK2A3 NOP2 VARS1 USP19	6.81e-06	638	91	10	33239621
Pubmed	Modifier genes and protective alleles in humans and mice.	MAP1A CFTR CDH23	9.47e-06	16	91	3	12787792
Pubmed	Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.	PTPN3 PIK3C2B SPTB PRDX1 PRKDC VARS1	1.11e-05	190	91	6	15161933
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	EDF1 HIP1 FAF2 KHDRBS1 PSMB6 TJP2 DPYSL4 PRKDC PEX11B SNRPA1 NOP2 VARS1 USP19 HDLBP	1.24e-05	1367	91	14	32687490
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	KHDRBS1 CENPF CSNK2A1 SYNE1 PRDX1 TJP2 PRKDC ASCC3 SNRPA1 NOP2 VARS1 HDLBP	1.48e-05	1024	91	12	24711643
Pubmed	Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation.	CSNK2A1 CSNK2A3	2.03e-05	3	91	2	15684395
Pubmed	The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates.	CFTR USP19	2.03e-05	3	91	2	19465887
Pubmed	Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.	CSNK2A1 CSNK2A3	2.03e-05	3	91	2	2174700
Pubmed	Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit.	CSNK2A1 CSNK2A3	2.03e-05	3	91	2	1766873
Pubmed	ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.	ARMCX2 ARMCX1	2.03e-05	3	91	2	11162520
Pubmed	Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways.	CFTR LGALS9	2.03e-05	3	91	2	21263071
Pubmed	Crystallization and preliminary characterization of crystals of human protein kinase CK2.	CSNK2A1 CSNK2A3	2.03e-05	3	91	2	11092945
Pubmed	Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line.	CSNK2A1 CSNK2A3	2.03e-05	3	91	2	12102635
Pubmed	Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.	CSNK2A1 CSNK2A3	2.03e-05	3	91	2	20625391
Pubmed	IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.	P2RX7 CDH23 PRKDC	2.95e-05	23	91	3	34473953
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	EDF1 KHDRBS1 CSNK2A1 EXOSC3 PRKDC ASCC3 PATJ NOP2 HDLBP	3.45e-05	615	91	9	31048545
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	KMT2D SLC41A3 CSNK2A1 DLGAP5 TJP2 PPP1R18 PRKDC NOP2 USP19 HDLBP	3.57e-05	774	91	10	15302935
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	HIP1 FAF2 KHDRBS1 PIK3C2B ANTXR1 ASCC3 USP19 HDLBP	3.93e-05	481	91	8	28190767
Pubmed	Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis.	ERBB2 CDH23	4.05e-05	4	91	2	23592719
Pubmed	Attenuation of Th1 response through galectin-9 and T-cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice.	PRKDC LGALS9	4.05e-05	4	91	2	19670381
Pubmed	Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes.	ERBB2 POLR1B	4.05e-05	4	91	2	21555369
Pubmed	Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells.	CSNK2A1 PRKDC	4.05e-05	4	91	2	20711232
Pubmed	CK2-dependent phosphorylation of occludin regulates the interaction with ZO-proteins and tight junction integrity.	CSNK2A1 TJP2	4.05e-05	4	91	2	23758859
Pubmed	Distribution of centromeric proteins and PARP-1 during mitosis and apoptosis.	CENPB CENPF	4.05e-05	4	91	2	19723035
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	FAF2 KHDRBS1 MAP1A CSNK2A1 PRDX1 PSMB6 EXOSC3 PRKDC ASCC3 SNRPA1 NOP2 OPLAH HDLBP	4.40e-05	1335	91	13	29229926
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	KHDRBS1 CSNK2A1 CIP2A PRDX1 PSMB6 EXOSC3 PRKDC ASCC3 PATJ SNRPA1 VARS1 HDLBP	4.56e-05	1149	91	12	35446349
Pubmed	Role of the E3 ubiquitin-ligase Hakai in intestinal inflammation and cancer bowel disease.	KHDRBS1 PRKDC VARS1	4.84e-05	27	91	3	36266428
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	VPS13D CENPF PIK3C2B CSNK2A1 TJP2 ASCC3 CSNK2A3 HYDIN	4.95e-05	497	91	8	36774506
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FAF2 DLGAP5 PRDX1 PSMB6 EXOSC3 POLR1B PRKDC ASCC3 SNRPA1 NOP2 ARMCX1 VARS1 HDLBP	5.04e-05	1353	91	13	29467282
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	DZANK1 FAF2 KHDRBS1 PRDX1 PRKDC ASCC3 SNRPA1 NOP2 VARS1 HDLBP	5.16e-05	809	91	10	32129710
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	CENPF CIP2A DLGAP5 PRKDC SNRPA1 HDLBP	5.93e-05	256	91	6	33397691
Pubmed	Protein kinase CK2 localizes to sites of DNA double-strand break regulating the cellular response to DNA damage.	CSNK2A1 PRKDC	6.74e-05	5	91	2	22404984
Pubmed	Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors.	ERBB2 PIK3C2B	6.74e-05	5	91	2	10805725
Pubmed	Adaptation of sequential action benefits from timing variability related to lateral basal ganglia circuitry.	P2RX7 CDH23	6.74e-05	5	91	2	38496293
Pubmed	ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.	FAF2 KHDRBS1 CIP2A NOP2 VARS1	7.79e-05	166	91	5	35687106
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	EDF1 CENPF CSNK2A1 TRPM1 PRKDC SNRPA1 ARMCX1	8.38e-05	396	91	7	26687479
Pubmed	Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.	PIK3C2B TJP2 ANTXR1 ASCC3 SNX19	8.47e-05	169	91	5	31462741
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DZANK1 KHDRBS1 MAP1A CSNK2A1 SYNE1 SPTB PRDX1 TJP2 PPP1R18 DPYSL4 DAGLA VARS1 HDLBP	8.88e-05	1431	91	13	37142655
Pubmed	Defining human ERAD networks through an integrative mapping strategy.	KMT2D FAF2 PSMB6 PRKDC PEX11B	9.46e-05	173	91	5	22119785
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FAF2 MROH1 SYNE1 SNX19 USP19 PLXNB3 EPM2AIP1	9.93e-05	407	91	7	12693553
Pubmed	A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells.	CRACR2A CRACR2B	1.01e-04	6	91	2	20418871
Pubmed	Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.	CSNK2A1 PRKDC	1.01e-04	6	91	2	11883897
Pubmed	The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.	CSNK2A1 PRKDC	1.01e-04	6	91	2	10951572
Pubmed	Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype.	CENPB CENPF	1.01e-04	6	91	2	11084331
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	KHDRBS1 SYNE1 PRDX1 PSMB6 TJP2 PRKDC SNRPA1 NOP2 VARS1	1.08e-04	714	91	9	28302793
Pubmed	SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.	PIK3C2B PRDX1 PSMB6 PRKDC ATP1A4 SNRPA1 NOP2 VARS1	1.11e-04	558	91	8	27591049
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	EDF1 MAP1A EXOSC3 TJP2 POLR1B ASCC3 NOP2 VARS1 HDLBP	1.20e-04	724	91	9	36232890
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	ERBB2 CIP2A PRDX1 PSMB6 TJP2 PPP1R18 PATJ HDLBP	1.20e-04	565	91	8	25468996
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	EDF1 KHDRBS1 MAP1A CSNK2A1 SYNE1 PRDX1 DPYSL4 PRKDC SNRPA1 VARS1 ALPG	1.23e-04	1082	91	11	38697112
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ERBB2 SLC41A3 SPTB GPATCH2 EXOSC3 ZFHX2 ANTXR1 PATJ ZSWIM4 GPT2 DAGLA SCARA3 FAM149A	1.32e-04	1489	91	13	28611215
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	SYNE1 CIP2A SPTB PRDX1 PARP14	1.36e-04	187	91	5	26460568
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	ERBB2 VPS13D FAF2 KHDRBS1 CENPF SYNE1 CIP2A PSMB6 ARMCX2 PEX11B NOP2 SNX19 USP19	1.38e-04	1496	91	13	32877691
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	DZANK1 HIP1 CSNK2A1 CFTR TJP2 DAGLA ARMCX1	1.39e-04	430	91	7	32581705
Pubmed	Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity.	ERBB2 CSNK2A1	1.41e-04	7	91	2	21419342
Pubmed	Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation.	ERBB2 CSNK2A1	1.41e-04	7	91	2	21075308
Pubmed	A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.	CSNK2A1 CSNK2A3	1.41e-04	7	91	2	11239457
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	PTPN3 PIK3C2B CSNK2A1 TJP2	1.53e-04	102	91	4	15778465
Pubmed	mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.	FAF2 PRDX1 PSMB6 PRKDC VARS1 HDLBP	1.75e-04	312	91	6	37120454
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	FAM234B FAF2 CIP2A PSMB6 PRKDC ASCC3 PEX11B VARS1 USP19 HDLBP	1.80e-04	942	91	10	31073040
Pubmed	Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF.	TJP2 PATJ	1.88e-04	8	91	2	22006950
Pubmed	Vigilins bind to promiscuously A-to-I-edited RNAs and are involved in the formation of heterochromatin.	PRKDC HDLBP	1.88e-04	8	91	2	15723802
Pubmed	p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.	CSNK2A1 CSNK2A3	1.88e-04	8	91	2	12393879
Pubmed	Characterization of the deubiquitinating activity of USP19 and its role in endoplasmic reticulum-associated degradation.	FAF2 USP19	1.88e-04	8	91	2	24356957
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	KHDRBS1 PRKDC ASCC3 NOP2 HDLBP	1.95e-04	202	91	5	24639526
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DZANK1 P2RX7 CENPF CSNK2A1 SYNE1 DLGAP5 PRDX1 DPYSL4 NOP2 EPM2AIP1	2.14e-04	963	91	10	28671696
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	CENPB CENPF DLGAP5 PRKDC NOP2	2.34e-04	210	91	5	16565220
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	PTPN3 FAF2 CSNK2A1 CIP2A TJP2 PRKDC ASCC3 SNRPA1 NOP2 VARS1	2.35e-04	974	91	10	28675297
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	KMT2D EXOSC3 ASCC3 ARMCX2 PARP14 ARMCX1 HYDIN	2.37e-04	469	91	7	27634302
Pubmed	S-glutathionylation of Hsp90 enhances its degradation and correlates with favorable prognosis of breast cancer.	ERBB2 CSNK2A1	2.41e-04	9	91	2	36279628
Pubmed	Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2.	CSNK2A1 PRKDC	2.41e-04	9	91	2	24657168
Pubmed	Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase.	CSNK2A1 PRKDC	2.41e-04	9	91	2	10747897
Pubmed	Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2.	FAF2 KHDRBS1 PRDX1 PSMB6 EXOSC3 PRKDC	2.48e-04	333	91	6	36779763
Pubmed	Viral immune modulators perturb the human molecular network by common and unique strategies.	CSNK2A1 SYNE1 PRDX1 USP19	2.51e-04	116	91	4	22810585
Pubmed	Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.	KHDRBS1 CSNK2A1 NOP2 RAD17	2.51e-04	116	91	4	21282530
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	KHDRBS1 CENPF CSNK2A1 DLGAP5 PRDX1 EXOSC3 PRKDC SNRPA1 NOP2 VARS1	2.65e-04	989	91	10	36424410
Pubmed	A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.	CENPF DLGAP5 TJP2 PPP1R18	2.68e-04	118	91	4	30979931
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	EDF1 KHDRBS1 SYNE1 PRDX1 PRKDC ASCC3 SNRPA1 NOP2 HDLBP	2.68e-04	807	91	9	22681889
Pubmed	Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3η as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability.	EDF1 KHDRBS1 NOP2 VARS1 HDLBP	3.21e-04	225	91	5	31478661
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	FAF2 KHDRBS1 CENPF CSNK2A1 SYNE1 PRDX1 PRKDC SNRPA1 NOP2 VARS1 USP19 HDLBP	3.39e-04	1425	91	12	30948266
Cytoband	Xq21.33-q22.2	ARMCX2 ARMCX1	3.89e-06	2	91	2	Xq21.33-q22.2
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	ODAD2 ARMCX2 ARMCX1	4.10e-04	43	61	3	409
GeneFamily	ATP binding cassette subfamily C	ABCC3 CFTR	8.53e-04	13	61	2	807
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 CFTR DPYSL4 GPT2 SCARA3 OPLAH	2.44e-06	188	91	6	842982de2197770f999a70083ed9fca40ac22d79
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 CFTR DPYSL4 GPT2 SCARA3 OPLAH	2.44e-06	188	91	6	a0815eaf68eedd6e5ec4af520df80a6ab4eb0864
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells-Ciliated\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DZANK1 MAP1A HEATR9 ODAD2 HYDIN	1.61e-05	154	91	5	9ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DZANK1 MAP1A HEATR9 ODAD2 HYDIN	1.61e-05	154	91	5	58072ce422d09f2de602580325eaac6c4ec6c136
ToppCell	NS-moderate-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MAP1A CENPF DLGAP5 HYDIN FAM149A	1.77e-05	157	91	5	410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ABCC3 TMEM132D CRACR2B PATJ FAM149A	2.06e-05	162	91	5	5c9bc3c3857a99d8a3caf359a7eb279ce9cc1c81
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CENPF CIP2A DLGAP5 VARS1 FCMR	2.19e-05	164	91	5	249d8f75a64bce7db52ce0c563f496b9edf602a6
ToppCell	control-Myeloid-pDC\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SYCP2L MAP1A PATJ NOP2 RAD17	2.45e-05	168	91	5	affc39c7568b7df4b36af6f5b0e3702a18b6268c
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 CFTR DPYSL4 GPT2 SCARA3	2.67e-05	171	91	5	5447b78148f7bccb727e2fc108589b2af02a5d31
ToppCell	droplet-Pancreas-Exocrine\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB2 CRACR2B GPT2 SCARA3 LGALS9	2.67e-05	171	91	5	92ac4cc3d54da2ea8e202aa59c78e8875356649e
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_ductal_cel\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 CFTR DPYSL4 GPT2 SCARA3	2.75e-05	172	91	5	a7eee0a30d2fe20c865a07b9004c6a821a72c0c4
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 CFTR DPYSL4 GPT2 SCARA3	2.75e-05	172	91	5	0a9fe2cd28203970295a1288078c66eadac1c9ed
ToppCell	droplet-Lung-1m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CENPF C19orf67 CIP2A DLGAP5 HEATR9	2.82e-05	173	91	5	c399786aa25bdbe3394988db6955842b5b7e6b41
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TMEM132D CFTR CRACR2B PATJ FAM149A	3.41e-05	180	91	5	b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mast-Mast-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CENPF CIP2A SPTB DLGAP5 CSNK2A3	3.50e-05	181	91	5	c35ca98c474e31917e0a53c092397e0d8d18b37c
ToppCell	droplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CENPF CIP2A DLGAP5 PLXNB3 ALPG	3.69e-05	183	91	5	e91f00b75d43ee6293fdd4a129b789cd95f8d11a
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	PTPN3 ERBB2 CFTR PATJ FAM149A	3.89e-05	185	91	5	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	Adult-Epithelial-club_cell-D231\|Adult / Lineage, Cell type, age group and donor	TMEM130 CFTR CRACR2B PATJ FAM149A	4.09e-05	187	91	5	ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 CFTR DPYSL4 GPT2 SCARA3	4.09e-05	187	91	5	9aa411ae9b5a923378a5daebb8bb2fc2613f2510
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN3 TJP2 CRACR2B PARP14 GPT2	4.41e-05	190	91	5	6ea9fa08bd97bedcb21d3654467e7f8dd74c8fd0
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ABCC3 TMEM132D CFTR PATJ FAM149A	4.53e-05	191	91	5	60ff989fe99d243a3d52955223680cdd1f1917a4
ToppCell	Epithelial-club_cell\|World / Lineage, Cell type, age group and donor	TMEM130 CFTR CRACR2B PATJ FAM149A	4.76e-05	193	91	5	2bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCell	BLOOD--(1)_T_cell-(1)_Activated_T_cells\|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	CENPF DLGAP5 PRDX1 PPP1R18 LGALS9	4.87e-05	194	91	5	6a0cbb9d5c5c4effb02dff654c6c3b184026875c
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN3 ERBB2 TJP2 CRACR2B GPT2	4.99e-05	195	91	5	b9a1c5836eb0ca92df788c3ee093b0d9ec7b8ad9
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PTPN3 KHDRBS1 CENPF CIP2A DLGAP5	5.24e-05	197	91	5	196eaecef7003ed83f323c1f157c6a3594650097
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DLGAP5 CDH23 ACOT4 CR1 GPT2	5.50e-05	199	91	5	c6d59ed26eadd3c41acfe1b4d929270e00ea3e95
ToppCell	Parenchymal-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CYP2C9 TMEM132D PPP1R18 ODAD2 BTN2A1	5.50e-05	199	91	5	6f5ef959b51eccf1ffc2e5ddf0d83c62ca2257b2
ToppCell	Parenchymal-NucSeq-Stromal-Peri/Epineurial_\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CYP2C9 TMEM132D PPP1R18 ODAD2 BTN2A1	5.50e-05	199	91	5	1aa99d21bf61b86df4a966dc47634044430aa39f
ToppCell	TCGA-Stomach-Primary_Tumor\|TCGA-Stomach / Sample_Type by Project: Shred V9	CENPF CIP2A DLGAP5 POLR1B NOP2	5.50e-05	199	91	5	38f1f612b29feb868322999ceeda78e52447ec4f
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma\|TCGA-Stomach / Sample_Type by Project: Shred V9	CENPF CIP2A DLGAP5 POLR1B NOP2	5.50e-05	199	91	5	b10698aee2e6c17bc559eb4f723024141f914b90
ToppCell	TCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma-Intrahepatic\|TCGA-Bile_Duct / Sample_Type by Project: Shred V9	HIP1 FAF2 CSNK2A1 ZSWIM4 RAD17	5.63e-05	200	91	5	1fa8422fd820d21e285a7e7c4c6fbd8b7277d2af
ToppCell	control-Lymphoid-NKT-proliferating\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CENPF DLGAP5 PRDX1 TJP2 CRACR2B	5.63e-05	200	91	5	f8b5e5464b2ffef7b0ce75f60839c8ef791e17ba
ToppCell	COVID_vent\|World / Disease condition, Lineage, Cell class and subclass	CENPF DLGAP5 PRDX1 CR1 HDLBP	5.63e-05	200	91	5	1d88e5cc4534073f27a7562e1c4b884bd67f09d9
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	ERBB2 CDH23 TMEM220 SCARA3 LGALS9	5.63e-05	200	91	5	be1abe5bb1ce4e7dfec63af4ed0fc5b96bf77866
ToppCell	droplet-Skin-nan-18m-Epithelial-basal_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPD1 ABCC3 LGALS9 FCMR	8.23e-05	112	91	4	32c6ab8e9b71c6c3df7e3e119b88e6ad1b895d50
Disease	chronic obstructive pulmonary disease, interleukin-8 measurement	P2RX7 HYDIN	5.02e-05	4	86	2	EFO_0000341, EFO_0004811
Disease	Primary ciliary dyskinesia	CENPF ODAD2 HYDIN	1.59e-04	36	86	3	cv:C0008780
Disease	X-16935 measurement	ABCC3 ACOT4	1.75e-04	7	86	2	EFO_0800763
Disease	ecosanoids measurement	ABCC3 CYP2C9 ACOT4	5.62e-04	55	86	3	EFO_0020044
Disease	ethylmalonate measurement	P2RX7 TMEM132D	1.54e-03	20	86	2	EFO_0020009
Disease	Nasopharyngeal carcinoma	ERBB2 SYNE1	1.87e-03	22	86	2	C2931822
Disease	Carcinoma of lung	ERBB2 CSNK2A3	2.04e-03	23	86	2	C0684249
Disease	Cholangiocarcinoma	PTPN3 ERBB2	2.61e-03	26	86	2	C0206698
Disease	docosapentaenoic acid measurement	SYCP2L DAGLA	2.81e-03	27	86	2	EFO_0006809

Protein segments in the cluster

Peptide	Gene	Start	Entry
GPIVLKAGEIELELQ	GPT2	66	Q8TD30
TEILKGGVLIQRNPQ	ERBB2	146	P04626
QIRQGLEELQKVLPG	ANTXR1	101	Q9H6X2
GEVTKAVQPLLLGRI	CFTR	91	P13569
PKGLLLLQRTGAINE	TBC1D32	691	Q96NH3
AVGDRVPVLLLGNKL	CRACR2A	646	Q9BSW2
DNIAKLGQIIREGPI	CDH23	3196	Q9H251
IKLFVGQIPRGLDEQ	CELF6	46	Q96J87
QETIRKLGGLPIIAN	ARMCX2	421	Q7L311
VLERQPKQGGSILLI	RAD17	121	O75943
PKLNEGDQIVLINGR	PTPN3	551	P26045
SGVERQVLLGDQIPK	PSMB6	216	P28072
LKQVEGIRQGELQLL	ABCC3	511	O15438
LQVRDLSLKLQGIPG	ARHGEF19	651	Q8IW93
PGINGLLQRKVAELE	MAP1A	96	P78559
GDNQIVPKTGLLIIV	MAGEA12	191	P43365
VLGRQLILPTDKGVQ	FAM149A	321	A5PLN7
LPTINRLEVGGDIQL	LGALS9	336	O00182
PNNQVLGKIERAIGL	EDF1	116	O60869
GRQPLEVQPLLKLGQ	PLXNB3	381	Q9ULL4
GVRDLVVLAIGELQP	FAM234B	271	A2RU67
LQERGGVLQEKVPEI	MROH1	1081	Q8NDA8
KGILRQITVNDLPVG	PRDX1	136	Q06830
DGIPKGDLQQRELQL	PIK3C2B	1576	O00750
GLRLQLSLGIIPVEE	ALPG	11	P10696
ALGQGVARLVLPKLE	PRICKLE4	66	Q2TBC4
GVVLIVQQGDLARLP	PARP14	801	Q460N5
LLGRSLQDVKGQEVP	P2RX7	416	Q99572
LIKQIGENLIVPGGI	DPYSL4	41	O14531
QQIRAAGLPVKGIIL	CENPB	86	P07199
EIKILENLRGGPNII	CSNK2A3	81	Q8NEV1
ANRIVKLGAVLPGQV	HYDIN	4421	Q4G0P3
EVITKLDGLPIGRVQ	C2CD3	116	Q4AC94
GLPTRALQKIQELEG	CENPF	11	P49454
GRVLLPLNLQLGAKV	CR1	1721	P17927
LLVFIRGVGPELEVQ	EPM2AIP1	191	Q7L775
VLEQLGVAPVLGKQR	CRACR2B	141	Q8N4Y2
GPLQELVRKGLLEIS	C19orf67	151	A6NJJ6
GLKDVNIPTLEGRIL	DLGAP5	46	Q15398
RAQGKEPNLSLLLGI	CEP85L	736	Q5SZL2
SVERKGEVLLIPQNG	BTN2A1	406	Q7KYR7
EIKILENLRGGPNII	CSNK2A1	81	P68400
PNGLKLISEVIGERL	GPD1	126	P21695
LGKDLVPRIGLSQLE	DAGLA	521	Q9Y4D2
REKLQEVLQDLGLGP	GPR156	546	Q8NFN8
ILGPQGNTIKRLQEE	KHDRBS1	176	Q07666
LPVIGNILQIGIKDI	CYP2C9	36	P11712
QLIPENRLLLKEVGP	DZANK1	601	Q9NVP4
IIRQGPKIQDEGVVL	GPATCH2	216	Q9NW75
LLQPELQGGLRTKAL	PPP1R18	591	Q6NYC8
GGLPQLALKLRLQVL	PEX11B	181	O96011
GPEIRKLQEELEGIQ	SCARA3	126	Q6AZY7
RTVLGQVVLPGEELL	EXOSC3	21	Q9NQT5
QGKLLLLEPERQEEG	PRM3	71	Q9NNZ6
GIVPQLLVNLRGADK	OR2B8P	76	P59922
LAGEKLRELILPGAQ	PANX2	16	Q96RD6
LQGLVDPARELGKLQ	VARS1	1191	P26640
LQGLVTEKIQLLEGL	SYNE1	7006	Q8NF91
VEEPRIAKLQGGQIL	TMEM132D	616	Q14C87
EVERLKGLLQSGQIP	SNRPA1	216	P09661
VIVRKCGGIQPLVNL	ODAD2	791	Q5T2S8
LEVQQPVDLGALRGK	OPLAH	161	O14841
VGRLEGLIQPDDLIN	FAF2	246	Q96CS3
ELLPRGLDIKQEELG	HIP1	766	O00291
IVIGARKLGVNPDNI	SLC41A3	206	Q96GZ6
QALINRGVNLDPLGK	NOP2	326	P46087
IEKAQGPILLIVGQD	ACOT4	311	Q8N9L9
LLGPEGLELIEKLLQ	ASCC3	271	Q8N3C0
PQQKLIIVEGCQRLG	ATP1A4	701	Q13733
NAIRELGGVPIIAKL	ARMCX1	241	Q9P291
GVPGLNIEELIEKLQ	CIP2A	591	Q8TCG1
EVIVKLRVGVGPLQL	USP19	126	O94966
LAVRIGNELEKGLIP	TJP2	646	Q9UDY2
EVLGEEIGLPKRVIQ	ZFHX2	2096	Q9C0A1
KNPVGGRIQLAIAIV	TMEM220	116	Q6QAJ8
LKVGDRIVSINGQPL	PATJ	1721	Q8NI35
GLKEDEPLLIRQGLI	SYCP2L	96	Q5T4T6
ALRILPEVKVEGELG	FCMR	16	O60667
VGDEGKLVPVLQTLI	HEATR9	256	A2RTY3
PEGEQIIRLQGQVDK	SPTB	1656	P11277
GVLPDLVVEILGVNK	SNX19	916	Q92543
LIQGLIDENPGLQLI	PRKDC	2506	P78527
GGLVEKFQEVIPQLL	ZNF862	706	O60290
LQKINTRLGQGVPLV	TRPM1	236	Q7Z4N2
LKLQETLRGIQVLGP	TMEM130	236	Q8N3G9
VILRGEPEKLGQALT	HDLBP	341	Q00341
VRNLQQKGLGEIPLD	TOGARAM1	1421	Q9Y4F4
RPVQNLALGKEELIG	POLR1B	621	Q9H9Y6
KGPQLIIDIRSNVGE	TRAV13-1	61	A0A0B4J241
LVQVLRKQAGLLLEG	ZSWIM4	511	Q9H7M6
GIGLSLINKVPEELV	VPS13D	3836	Q5THJ4
NGRPEFVIKVIEQGL	KMT2D	5236	O14686