Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	TRPM4 GRIA3 ITPR1	1.20e-04	31	62	3	GO:0099604
GeneOntologyMolecularFunction	molecular condensate scaffold activity	UBQLN2 DAXX CAPRIN1	3.00e-04	42	62	3	GO:0140693
GeneOntologyMolecularFunction	ubiquitin protein ligase binding	RRAGA RNF20 TNK2 DAXX RNF40 SMG5	6.14e-04	337	62	6	GO:0031625
GeneOntologyMolecularFunction	calcium channel activity	TRPM4 GRIA3 CNGA1 ITPR1	6.94e-04	129	62	4	GO:0005262
GeneOntologyMolecularFunction	ubiquitin-like protein ligase binding	RRAGA RNF20 TNK2 DAXX RNF40 SMG5	8.41e-04	358	62	6	GO:0044389
GeneOntologyMolecularFunction	SNARE binding	TSNARE1 VPS50 RNF40 PICALM	8.46e-04	136	62	4	GO:0000149
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	TRPM4 GRIA3 CNGA1 ITPR1	9.42e-04	140	62	4	GO:0099094
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	TRPM4 GRIA3 CNGA1 ITPR1	1.25e-03	151	62	4	GO:0015085
GeneOntologyBiologicalProcess	protein depolymerization	LMOD3 SPAST SH3GL3 RP1 NCKAP5L ADD2	4.22e-06	144	61	6	GO:0051261
GeneOntologyBiologicalProcess	clathrin-dependent endocytosis	UBQLN2 SH3GL3 TNK2 PICALM	1.82e-05	53	61	4	GO:0072583
GeneOntologyBiologicalProcess	protein-containing complex disassembly	LMOD3 SPAST SH3GL3 UBQLN4 RP1 NCKAP5L ADD2	2.35e-05	291	61	7	GO:0032984
GeneOntologyBiologicalProcess	regulation of clathrin-dependent endocytosis	UBQLN2 SH3GL3 TNK2	3.15e-05	21	61	3	GO:2000369
GeneOntologyBiologicalProcess	regulation of protein-containing complex disassembly	LMOD3 SPAST UBQLN4 RP1 ADD2	6.72e-05	144	61	5	GO:0043244
GeneOntologyBiologicalProcess	microtubule bundle formation	CCDC66 SPAST RP1 NCKAP5L CFAP65	6.94e-05	145	61	5	GO:0001578
GeneOntologyBiologicalProcess	negative regulation of clathrin-dependent endocytosis	UBQLN2 SH3GL3	8.55e-05	5	61	2	GO:1900186
GeneOntologyBiologicalProcess	regulation of receptor-mediated endocytosis	UBQLN2 SH3GL3 TNK2 CBL PICALM	9.81e-05	156	61	5	GO:0048259
GeneOntologyBiologicalProcess	negative regulation of protein-containing complex disassembly	LMOD3 UBQLN4 RP1 ADD2	2.20e-04	100	61	4	GO:0043242
GeneOntologyBiologicalProcess	negative regulation of receptor-mediated endocytosis	UBQLN2 SH3GL3 PICALM	2.25e-04	40	61	3	GO:0048261
GeneOntologyBiologicalProcess	regulation of protein depolymerization	LMOD3 SPAST RP1 ADD2	2.65e-04	105	61	4	GO:1901879
GeneOntologyCellularComponent	HULC complex	RNF20 RNF40	5.17e-05	4	62	2	GO:0033503
GeneOntologyCellularComponent	parallel fiber to Purkinje cell synapse	PPFIA4 GRIA3 PICALM	2.82e-04	43	62	3	GO:0098688
GeneOntologyCellularComponent	ubiquitin conjugating enzyme complex	RNF20 RNF40	3.07e-04	9	62	2	GO:0031371
GeneOntologyCellularComponent	lipid droplet	SPAST VPS13C HSD17B13 AQP7P3	3.92e-04	116	62	4	GO:0005811
GeneOntologyCellularComponent	postsynapse	DLG5 TRIO SH3GL3 TNK2 GRIA3 CAPRIN1 PICALM GPR179 ADD2 ITPR1	7.69e-04	1018	62	10	GO:0098794
Domain	RFX1_trans_act	RFX1 RFX2 RFX3	2.84e-08	3	58	3	IPR007668
Domain	RFX1_trans_act	RFX1 RFX2 RFX3	2.84e-08	3	58	3	PF04589
Domain	RFX_DNA_binding	RFX1 RFX2 RFX3	2.36e-06	9	58	3	PF02257
Domain	DNA-bd_RFX	RFX1 RFX2 RFX3	2.36e-06	9	58	3	IPR003150
Domain	RFX_DBD	RFX1 RFX2 RFX3	2.36e-06	9	58	3	PS51526
Domain	UBA	UBQLN2 UBQLN4 CBL	1.09e-04	30	58	3	SM00165
Domain	Ubiquilin	UBQLN2 UBQLN4	1.41e-04	6	58	2	IPR015496
Domain	UBA	UBQLN2 UBQLN4 CBL	1.89e-04	36	58	3	PF00627
Domain	UBA	UBQLN2 UBQLN4 CBL	3.44e-04	44	58	3	IPR015940
Domain	UBA	UBQLN2 UBQLN4 CBL	4.18e-04	47	58	3	PS50030
Domain	STI1	UBQLN2 UBQLN4	4.20e-04	10	58	2	SM00727
Domain	STI1_HS-bd	UBQLN2 UBQLN4	4.20e-04	10	58	2	IPR006636
Domain	UBA-like	UBQLN2 UBQLN4 CBL	1.04e-03	64	58	3	IPR009060
Domain	6-PGluconate_DH_C-like	UBQLN2 UBQLN4	1.57e-03	19	58	2	IPR008927
Domain	Znf_RING_CS	TRIM11 RNF20 RNF40 CBL	1.64e-03	163	58	4	IPR017907
Domain	SH3	DLG5 TRIO SH3GL3 TNK2	4.53e-03	216	58	4	SM00326
Domain	SH3	DLG5 TRIO SH3GL3 TNK2	4.53e-03	216	58	4	PS50002
Domain	SH3_domain	DLG5 TRIO SH3GL3 TNK2	4.83e-03	220	58	4	IPR001452
Domain	zf-C3HC4	TRIM11 RNF20 RNF40 CBL	5.07e-03	223	58	4	PF00097
Domain	Ion_trans_dom	TRPM4 CNGA1 ITPR1	5.35e-03	114	58	3	IPR005821
Domain	Ion_trans	TRPM4 CNGA1 ITPR1	5.35e-03	114	58	3	PF00520
Domain	UBIQUITIN_1	UBQLN2 UBQLN4	5.89e-03	37	58	2	PS00299
Domain	UBQ	UBQLN2 UBQLN4	7.89e-03	43	58	2	SM00213
Pubmed	Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element.	RFX1 RFX2 RFX3	5.39e-09	3	62	3	15024578
Pubmed	Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation.	RFX1 RFX2 RFX3	5.39e-09	3	62	3	12403718
Pubmed	RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.	RFX1 RFX2 RFX3	5.39e-09	3	62	3	8289803
Pubmed	Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.	RFX1 RFX2 RFX3	5.39e-09	3	62	3	10330134
Pubmed	Ciliogenic RFX transcription factors regulate FGF1 gene promoter.	RFX1 RFX2 RFX3	5.39e-09	3	62	3	22415835
Pubmed	Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis.	RFX1 RFX2 RFX3	5.39e-09	3	62	3	32725242
Pubmed	Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members.	RFX1 RFX2 RFX3	2.16e-08	4	62	3	11682486
Pubmed	Differential expression of Rfx1-4 during mouse spermatogenesis.	RFX1 RFX2 RFX3	2.16e-08	4	62	3	19596083
Pubmed	Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.	TRIO KXD1 RNF20 RNF40 CBL PICALM	4.90e-08	111	62	6	22558309
Pubmed	Structure of hRpn10 Bound to UBQLN2 UBL Illustrates Basis for Complementarity between Shuttle Factors and Substrates at the Proteasome.	UBQLN2 UBQLN4 PSMD2	1.88e-07	7	62	3	30664872
Pubmed	G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator.	PSMD2 RFX2 RFX3	8.81e-07	11	62	3	18218630
Pubmed	Defining the membrane proteome of NK cells.	ATP5PB PPP1R21 CELF1 IARS1 VPS50 PSMD2 TNK2 CHPF2 RNF40 CAPRIN1 PICALM ITPR1	8.92e-07	1168	62	12	19946888
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	ZNF106 CELF1 RNF20 PSMD2 DAXX RNF40 CAPRIN1 PICALM	1.23e-06	444	62	8	34795231
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	TRIM11 TRIO CEP162 SIPA1L3 XPO4 PSMD2 POC5 NCKAP5L ADD2 KNL1 ITPR1	2.22e-06	1049	62	11	27880917
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ZNF106 DLG5 SPAST TRIO CEP162 DSTYK SIPA1L3 ANKRD11 CBL NCKAP5L	2.76e-06	861	62	10	36931259
Pubmed	E3 Ubiquitin Ligases RNF20 and RNF40 Are Required for Double-Stranded Break (DSB) Repair: Evidence for Monoubiquitination of Histone H2B Lysine 120 as a Novel Axis of DSB Signaling and Repair.	RNF20 RNF40	3.13e-06	2	62	2	30692271
Pubmed	Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability.	RNF20 RNF40	3.13e-06	2	62	2	22354749
Pubmed	RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease.	RNF20 RNF40	3.13e-06	2	62	2	34088983
Pubmed	RFX1 and RFX3 Transcription Factors Interact with the D Sequence of Adeno-Associated Virus Inverted Terminal Repeat and Regulate AAV Transduction.	RFX1 RFX3	3.13e-06	2	62	2	29317724
Pubmed	RNF20/RNF40 ameliorates streptozotocin-induced type 1 diabetes by activating vitamin D receptors in vivo.	RNF20 RNF40	3.13e-06	2	62	2	37422774
Pubmed	Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells.	RNF20 RNF40	3.13e-06	2	62	2	20738173
Pubmed	The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19.	RFX1 RFX2	3.13e-06	2	62	2	1505960
Pubmed	Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation.	RNF20 RNF40	3.13e-06	2	62	2	34290256
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DLG5 SPAST CEP162 VPS13C VPS50 XPO4 RNF40 SMG5	4.47e-06	529	62	8	14621295
Pubmed	Rfx6 directs islet formation and insulin production in mice and humans.	RFX1 RFX2 RFX3	7.01e-06	21	62	3	20148032
Pubmed	The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis.	RFX1 RFX2 RFX3	8.11e-06	22	62	3	19887680
Pubmed	Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter.	RFX1 RFX3	9.37e-06	3	62	2	12411430
Pubmed	RFX transcription factors are essential for hearing in mice.	RFX1 RFX3	9.37e-06	3	62	2	26469318
Pubmed	The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitination.	RNF20 RNF40	9.37e-06	3	62	2	22021426
Pubmed	RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response.	RNF20 RNF40	9.37e-06	3	62	2	21827756
Pubmed	The RING finger domain E3 ubiquitin ligases BRCA1 and the RNF20/RNF40 complex in global loss of the chromatin mark histone H2B monoubiquitination (H2Bub1) in cell line models and primary high-grade serous ovarian cancer.	RNF20 RNF40	9.37e-06	3	62	2	27798111
Pubmed	Ruk is ubiquitinated but not degraded by the proteasome.	SH3GL3 CBL	9.37e-06	3	62	2	12135478
Pubmed	Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth.	RNF20 RNF40	9.37e-06	3	62	2	22155569
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	ATP5PB SH3GL3 RNF20 XPO4 CHPF2 RNF40	1.20e-05	285	62	6	32838362
Pubmed	Ring finger 20/ring finger 40/WW domain-containing adaptor with coiled-coil complex interacts with p53 to regulate gene transcription in DNA damage response.	RNF20 RNF40	1.87e-05	4	62	2	33868474
Pubmed	Fbxl19 recruitment to CpG islands is required for Rnf20-mediated H2B mono-ubiquitination.	RNF20 RNF40	1.87e-05	4	62	2	28453857
Pubmed	Histone H2B monoubiquitination regulates heart development via epigenetic control of cilia motility.	RNF20 RFX3	1.87e-05	4	62	2	31235600
Pubmed	CIP75 (connexin43-interacting protein of 75 kDa) mediates the endoplasmic reticulum dislocation of connexin43.	UBQLN4 PSMD2	1.87e-05	4	62	2	24256120
Pubmed	TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage.	RNF20 RNF40	1.87e-05	4	62	2	26781088
Pubmed	Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks.	RNF20 RNF40	1.87e-05	4	62	2	21362549
Pubmed	The RFX family interacts at the collagen (COL1A2) start site and represses transcription.	RFX1 RFX2	1.87e-05	4	62	2	11986307
Pubmed	Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes.	RNF20 RNF40	1.87e-05	4	62	2	38517892
Pubmed	A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43.	UBQLN4 PSMD2	1.87e-05	4	62	2	18079109
Pubmed	Herp enhances ER-associated protein degradation by recruiting ubiquilins.	UBQLN2 UBQLN4	1.87e-05	4	62	2	18307982
Pubmed	Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination.	RNF20 RNF40	1.87e-05	4	62	2	32672815
Pubmed	Transcriptional regulation of the Alström syndrome gene ALMS1 by members of the RFX family and Sp1.	RFX1 RFX2	1.87e-05	4	62	2	20381594
Pubmed	SUPT6H controls estrogen receptor activity and cellular differentiation by multiple epigenomic mechanisms.	RNF20 RNF40	1.87e-05	4	62	2	24441044
Pubmed	A human MAP kinase interactome.	ZNF106 KIAA1549L TNK2 DAXX MBD5 CBL NCKAP5L	2.52e-05	486	62	7	20936779
Pubmed	WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription.	RNF20 RNF40	3.12e-05	5	62	2	21329877
Pubmed	RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom.	RFX1 RFX3	3.12e-05	5	62	2	8600444
Pubmed	Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning.	RFX1 RFX3	3.12e-05	5	62	2	24531968
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	ATP5PB MICU3 SPAST TRIO IARS1 PSMD2 GRIA3 HMGCS1 CAPRIN1 ITPR1	3.12e-05	1139	62	10	36417873
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	DLG5 TRIO SIPA1L3 CAPRIN1 PICALM	3.66e-05	209	62	5	36779422
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ZNF106 TRIO VPS13C VPS50 RNF40 POC5 NCKAP5L KNL1	4.64e-05	733	62	8	34672954
Pubmed	Dynamic changes in cis-regulatory occupancy by Six1 and its cooperative interactions with distinct cofactors drive lineage-specific gene expression programs during progressive differentiation of the auditory sensory epithelium.	RFX1 RFX2	4.67e-05	6	62	2	31956913
Pubmed	RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control.	UBQLN2 UBQLN4	4.67e-05	6	62	2	35247097
Pubmed	Structure and Function of the RING Domains of RNF20 and RNF40, Dimeric E3 Ligases that Monoubiquitylate Histone H2B.	RNF20 RNF40	4.67e-05	6	62	2	27569044
Pubmed	Degradation of gap junction connexins is regulated by the interaction with Cx43-interacting protein of 75 kDa (CIP75).	UBQLN4 PSMD2	4.67e-05	6	62	2	25583071
Pubmed	The RPA-RNF20-SNF2H cascade promotes proper chromosome segregation and homologous recombination repair.	RNF20 RNF40	4.67e-05	6	62	2	37155876
Pubmed	Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.	DAXX HMGCS1 CAPRIN1	5.08e-05	40	62	3	28805822
Pubmed	RNF20/40-mediated eEF1BδL monoubiquitylation stimulates transcription of heat shock-responsive genes.	RNF20 RNF40	6.53e-05	7	62	2	30649429
Pubmed	RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow.	RFX2 RFX3	6.53e-05	7	62	2	22233545
Pubmed	Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5.	RNF20 RNF40	6.53e-05	7	62	2	27557628
Pubmed	The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination.	RNF20 RNF40	6.53e-05	7	62	2	24526689
Pubmed	CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing.	RNF20 RNF40	6.53e-05	7	62	2	19575011
Pubmed	Dynamic loss of H2B ubiquitylation without corresponding changes in H3K4 trimethylation during myogenic differentiation.	RNF20 RNF40	6.53e-05	7	62	2	22252316
Pubmed	Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting.	PPFIA4 GRIA3	6.53e-05	7	62	2	11931740
Pubmed	Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1.	RRAGA IARS1 RNF20 PSMD2 CAPRIN1	7.19e-05	241	62	5	23125841
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	ZNF106 DLG5 UBQLN2 CAPRIN1 KNL1	7.33e-05	242	62	5	34011540
Pubmed	Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking.	SH3GL3 CBL	8.69e-05	8	62	2	18602463
Pubmed	Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery.	UBQLN2 UBQLN4	8.69e-05	8	62	2	23459205
Pubmed	SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells.	PSMD2 ITPR1	1.12e-04	9	62	2	17502376
Pubmed	Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair.	RNF20 RNF40	1.12e-04	9	62	2	25533843
Pubmed	CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.	SH3GL3 CBL	1.12e-04	9	62	2	12177062
Pubmed	Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation.	TNK2 CBL	1.12e-04	9	62	2	17182860
Pubmed	Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins.	RFX1 RFX2	1.12e-04	9	62	2	8661125
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	DLG5 CCDC66 TRIO CEP162 VPS13C SIPA1L3 POC5 NCKAP5L	1.33e-04	853	62	8	28718761
Pubmed	Retinal degeneration and failure of photoreceptor outer segment formation in mice with targeted deletion of the Joubert syndrome gene, Ahi1.	RP1 CNGA1	1.39e-04	10	62	2	20592197
Pubmed	Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.	RRAGA IARS1	1.39e-04	10	62	2	22424946
Pubmed	Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A.	RNF20 RNF40	1.39e-04	10	62	2	37633270
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TRPM4 TRIO TSNARE1 SIPA1L3 ANKRD11 TNK2 RNF40 SMG5 MBD5	1.43e-04	1105	62	9	35748872
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	PPP1R21 VPS50 TNK2 CAPRIN1 PICALM	1.58e-04	285	62	5	34369648
Pubmed	The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met.	SH3GL3 CBL	1.70e-04	11	62	2	11894096
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	DLG5 CELF1 TRIO RFX1 CAPRIN1 KNL1	1.96e-04	472	62	6	38943005
Pubmed	Mdm2 facilitates the association of p53 with the proteasome.	PSMD2 CBL	2.04e-04	12	62	2	20479273
Pubmed	H2B ubiquitylation promotes RNA Pol II processivity via PAF1 and pTEFb.	RNF20 RNF40	2.04e-04	12	62	2	24837678
Pubmed	SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer.	DAXX CAPRIN1	2.04e-04	12	62	2	31911863
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	SPAST TRIO RNF20 POC5 MBD5 CBL PICALM	2.22e-04	689	62	7	36543142
Pubmed	UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.	UBQLN2 UBQLN4	2.41e-04	13	62	2	27477512
Pubmed	STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.	SIPA1L3 PSMD2 RNF40 RFX1 CAPRIN1	2.54e-04	316	62	5	31665637
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	PPP1R21 UBQLN2 UBQLN4 PSMD2 RNF40	2.77e-04	322	62	5	26514267
Pubmed	ZW10 links mitotic checkpoint signaling to the structural kinetochore.	SMG5 KNL1	2.81e-04	14	62	2	15824131
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	IARS1 PSMD2 RNF40 CAPRIN1	3.00e-04	179	62	4	36261009
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	TRIO IARS1 DSTYK ANKRD11 DAXX	3.19e-04	332	62	5	37433992
Pubmed	Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.	TNK2 CBL	3.23e-04	15	62	2	19144635
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	IARS1 PSMD2 HMGCS1 CBL CAPRIN1	3.75e-04	344	62	5	30333137
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	CELF1 SIPA1L3 ANKRD11 HMGCS1 MBD5 ITPR1	3.86e-04	536	62	6	15840001
Pubmed	Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.	UBQLN2 UBQLN4 PSMD2	3.87e-04	79	62	3	27325702
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	CELF1 SIPA1L3 ANKRD11 HMGCS1 MBD5 ITPR1	3.93e-04	538	62	6	10512203
Pubmed	Transcription factor TAp73 and microRNA-449 complement each other to support multiciliogenesis.	RFX2 RFX3	4.18e-04	17	62	2	31068677
Interaction	MAPRE3 interactions	DLG5 CCDC66 TRIO CEP162 SIPA1L3 CBL NCKAP5L	6.64e-06	230	62	7	int:MAPRE3
Cytoband	16q24.3	DPEP1 ANKRD11	2.28e-03	52	62	2	16q24.3
Cytoband	Ensembl 112 genes in cytogenetic band chr2q23	MBD5 GALNT13	2.37e-03	53	62	2	chr2q23
Cytoband	11p13	KIAA1549L CAPRIN1	2.64e-03	56	62	2	11p13
GeneFamily	Regulatory factor X family	RFX1 RFX2 RFX3	5.57e-07	8	40	3	1153
GeneFamily	Ubiquilin family	UBQLN2 UBQLN4	4.75e-05	5	40	2	783
GeneFamily	Ring finger proteins	TRIM11 RNF20 RNF40 CBL	3.11e-03	275	40	4	58
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	UBQLN2 CELF1 RRAGA VPS50 RNF20 NAIP RNF40	8.98e-09	191	62	7	39ef8e1d7cc3ebb11717e8a55501515e3b72b177
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B1\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	UBQLN2 CELF1 RRAGA VPS50 RNF20 NAIP	2.65e-07	190	62	6	2434b8ad2976eab7d9147012c28454ab29670709
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DLG5 TRIO PPFIA4 PSMD2 TNK2	5.22e-06	180	62	5	e4add4c94f892a2d93926e5c6dac6a738319d091
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	KIAA1549L CELF1 GRIA3 CFAP65	4.73e-05	143	62	4	5fb5a4ea93e5cce55d427e3b4a50a979504fad3c
ToppCell	facs-Marrow-T_cells-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPFIA4 GRIA3 SMG5 ITPR1	1.06e-04	176	62	4	74f851a398c7562dd713bc0d8d488c0037243112
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN GRIA3 GALNT13 ITPR1	1.06e-04	176	62	4	3027d34fd663c8a08544d469183dc45138916749
ToppCell	facs-Marrow-T_cells-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPFIA4 GRIA3 SMG5 ITPR1	1.06e-04	176	62	4	31b5459a978d5cdde0af03a77401e0464d8c95ba
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN GRIA3 GALNT13 ITPR1	1.08e-04	177	62	4	1dc69c661e70e7e22bd9d7cf953eb638da9fd43c
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN GRIA3 GALNT13 ITPR1	1.08e-04	177	62	4	426a9845df7fd13b02e744532c336c60bc4d4a22
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN GRIA3 GALNT13 ITPR1	1.20e-04	182	62	4	f5f42e23832d0210560009ce6fd8eee89751e252
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-3\|TCGA-Lung / Sample_Type by Project: Shred V9	SPAST KIAA1549L PSMD2 ADD2	1.25e-04	184	62	4	ea4ccebe2d54279fcc517e4f0bfa652b91a808bb
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF106 VPS13C PPFIA4 ANKRD11	1.25e-04	184	62	4	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN GRIA3 GALNT13 ITPR1	1.31e-04	186	62	4	4bb54043f944a979db91bde9a86dd66f498c7658
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN GRIA3 GALNT13 ITPR1	1.36e-04	188	62	4	e99e3765b48392c987cf0c5ccbded0655637d7b7
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	VPS13C ANKRD11 HMGCS1 ITPR1	1.36e-04	188	62	4	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN GRIA3 GALNT13 ITPR1	1.39e-04	189	62	4	ce3fbaf9642785c8adf6edaeae20998bca558928
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MICU3 PPFIA4 GALNT13 ITPR1	1.39e-04	189	62	4	f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SH3GL3 RP1 RFX2 GALNT13	1.42e-04	190	62	4	30b50d183d7649146eb1e79b47ba897355f1998a
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN GRIA3 GALNT13 ITPR1	1.42e-04	190	62	4	db19c72d8c8053262b535068c5a9d4d696989cb1
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HSD17B13 RP1 RFX3 CFAP65	1.42e-04	190	62	4	2fdc024d3d673a0134b74b4c5a63afe924995730
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN GPR179 ADD2 ITPR1	1.51e-04	193	62	4	6995ee29bf403a71247de92a37dfd851be5acf2e
ToppCell	15-Trachea-Epithelial-Multiciliated_cell\|Trachea / Age, Tissue, Lineage and Cell class	RP1 RFX2 RFX3 CFAP65	1.51e-04	193	62	4	aa3acc7571405169efb656d214f3a8cbf988362e
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN GPR179 ADD2 ITPR1	1.51e-04	193	62	4	7fcfb0f76789fa8d8caa18304cb43c8fd899a81b
ToppCell	3'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DLG5 NAIP RFX2 RFX3	1.57e-04	195	62	4	6a0460d949ccda7c9fe76870d3ee6c2f60677d61
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HSD17B13 RP1 RFX3 CFAP65	1.57e-04	195	62	4	79dc031258579ea328181dda33710dd897f1064a
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RP1 RFX2 RFX3 CFAP65	1.57e-04	195	62	4	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	moderate-Epithelial-Ciliated\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RP1 RFX2 RFX3 CFAP65	1.57e-04	195	62	4	e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCell	NS-moderate-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	RP1 RFX2 RFX3 CFAP65	1.63e-04	197	62	4	71fea4aa6ce96c7693fa94792d08770622873850
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	ZNF106 CEP162 VPS13C ANKRD11	1.66e-04	198	62	4	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	critical-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RP1 RFX2 RFX3 CFAP65	1.66e-04	198	62	4	ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCell	(10)_Ciliated-(2)_GFP_FOXI1\|(10)_Ciliated / shred by cell type by condition	CEP162 VPS13C ANKRD11 RFX3	1.69e-04	199	62	4	61b1ed2db71b96157b92b7535d1955a4033098da
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Mesenchymal-Unfolded_protein_responsible_cell\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	PPP1R21 SH3GL3 CHPF2 MBD5	1.73e-04	200	62	4	6b7314c425f6b40f1301dd39cc02b0436e96a2ec
Disease	amyotrophic lateral sclerosis type 15 (implicated_via_orthology)	UBQLN2 UBQLN4	1.26e-05	3	61	2	DOID:0060206 (implicated_via_orthology)
Disease	amyotrophic lateral sclerosis (implicated_via_orthology)	ZNF106 UBQLN2 UBQLN4	3.28e-05	30	61	3	DOID:332 (implicated_via_orthology)
Disease	Neurodevelopmental Disorders	SPAST TRIO ANKRD11 ITPR1	4.21e-05	93	61	4	C1535926
Disease	cardiac arrest (biomarker_via_orthology)	TRPM4 ITPR1	1.17e-04	8	61	2	DOID:0060319 (biomarker_via_orthology)
Disease	neurodegenerative disease (implicated_via_orthology)	UBQLN2 UBQLN4 PSMD2 GRIA3	2.35e-04	145	61	4	DOID:1289 (implicated_via_orthology)
Disease	protein-glutamine gamma-glutamyltransferase e measurement	DLG5 HSD17B13 RP1	2.65e-04	60	61	3	EFO_0020690
Disease	frontotemporal dementia (implicated_via_orthology)	UBQLN2 UBQLN4	2.74e-04	12	61	2	DOID:9255 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	RNF20 RNF40 ITPR1	4.00e-04	69	61	3	DOID:1682 (implicated_via_orthology)
Disease	skin sensitivity to sun	DPEP1 ANKRD11	7.03e-04	19	61	2	EFO_0004795
Disease	retinitis pigmentosa (implicated_via_orthology)	CCDC66 POC5	1.43e-03	27	61	2	DOID:10584 (implicated_via_orthology)
Disease	pappalysin‐1 measurement	CELF1 PSMD2	1.65e-03	29	61	2	EFO_0010618

Protein segments in the cluster

Peptide	Gene	Start	Entry
RNFFQALDNMPNLQE	NAIP	1311	Q13075
MLRIEFEQNLAANEQ	RNF40	461	O75150
LMRQQHEAAALNAVQ	ANKRD11	2606	Q6UB99
LNSFLAQENMRLQEL	RNF20	221	Q5VTR2
LNAMQLQNLAALAAA	CELF1	256	Q92879
VLMISENNFLFRNAA	ANKRD40	336	Q6AI12
RASAILNRMQNIQFE	HSD17B13	276	Q7Z5P4
NFIQDSMLDFENQTL	CAPRIN1	371	Q14444
RQQLQLMAQDAFRDV	DAXX	306	Q9UER7
LFDVQRNNIAMALEV	ATP5PB	166	P24539
IFQALQQECMRQLQA	TNK2	706	Q07912
ARMLLNDFLNDQNRD	HMGCS1	276	Q01581
ALNLEAMTIFQNRND	POC5	361	Q8NA72
FDLERQNQMLSALFQ	NCKAP5L	91	Q9HCH0
ANFLNMLLQANDIRE	GPR179	106	Q6PRD1
IFMNNFQLCSEINER	ITPR1	1286	Q14643
ENVAFALANMLRENR	LMOD3	296	Q0VAK6
QARQVMEREFNNLLA	PPFIA4	1086	O75335
MLQLCLFAIVDQENN	AQP7P3	181	A6NL99
FANLQEALLENMIQN	CFAP65	1856	Q6ZU64
FSILQAIMEAAVQNN	GRIA3	171	P42263
DRFEKTNEMLLNFNN	KXD1	36	Q9BQD3
RELLAQCQQSLAQAM	DLG5	6	Q8TDM6
MNIDINNNELRLLFS	KNL1	2256	Q8NG31
NQSFARVMEQRLAQL	KIAA1549L	1076	Q6ZVL6
QFLNNLEDFAIALNM	MICU3	431	Q86XE3
QQEMDSLTFRNLQLA	PPP1R21	56	Q6ZMI0
DIFINQAFDMQRDLQ	DSTYK	371	Q6XUX3
NQFNLMASDLIALNR	GALNT13	81	Q8IUC8
FVNNMVRAQKIQALD	CTSF	211	Q9UBX1
ELFQTMQRAQELAQR	CCDC66	531	A2RUB6
NQNFTDLLAELRMAQ	CEP162	781	Q5TB80
NFQVRMQEDAALLNK	MBD5	1016	Q9P267
AQNNIEMAKNILREF	CBL	881	P22681
MFNNRLQDERANLTT	DPEP1	46	P16444
VFREENNKASMRQNL	RP1	1966	P56715
MFNFLENDVEQVSQL	SH3GL3	201	Q99963
QESLLQQAQAQFRMA	SMG5	801	Q9UPR3
INQMLSDLNRVDFAN	RFX1	771	P22670
QMLSDLNRVDFANVQ	RFX2	536	P48378
QMLSDLNRVDFANVQ	RFX3	521	P48380
MSNVQLNSNFLALAR	PSMD2	321	Q13200
QSMLFDLNEAAANRV	SIPA1L3	346	O60292
FVRVENMVDQLLRNN	IARS1	416	P41252
NFRNVDSNLANLIMN	SPAST	316	Q9UBP0
NRAADLRQDFNLMEQ	ADD2	36	P35612
RAQLAMALFEQEQAN	CHPF2	756	Q9P2E5
ISNMNAARAEFQARI	CNGA1	396	P29973
RMNKNRINNAFFLND	CLTRN	106	Q9HBJ8
IQNQMDALLDFNVNS	PICALM	171	Q13492
NEGRALMQLDFQQFL	VPS50	871	Q96JG6
LRKQMQDALLFQAQA	TRIM11	146	Q96F44
LQEFSRRENLNAQMS	XPO4	206	Q9C0E2
NLQELFQEMSANVFR	TSNARE1	256	Q96NA8
NLQFVDMNSSRNLFV	SLC23A1	446	Q9UHI7
QLEMNLRNFAQIIEA	RRAGA	186	Q7L523
MNVSLNQEDLNLLFR	VPS13C	1351	Q709C8
RFQQQLEQLNAMGFL	UBQLN2	581	Q9UHD9
LEQLNAMGFLNREAN	UBQLN2	586	Q9UHD9
LNSMGFINREANLQA	UBQLN4	566	Q9NRR5
SLQCMDNNLLQARAA	ZNF106	1066	Q9H2Y7
QLAMQADARAFFAQD	TRPM4	656	Q8TD43
LASNQQNMFLVFRAA	TRIO	2581	O75962