Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunction[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity

HS3ST3B1 HS3ST3A1

1.25e-052712GO:0033872
GeneOntologyMolecularFunction[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity

HS3ST3B1 HS3ST3A1

2.59e-047712GO:0008467
GeneOntologyMolecularFunctionoxalate transmembrane transporter activity

SLC26A3 SLC26A4

5.51e-0410712GO:0019531
GeneOntologyMolecularFunctionsecondary active sulfate transmembrane transporter activity

SLC26A3 SLC26A4

6.72e-0411712GO:0008271
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

SORT1 EPHB6 OR2M4 ADGRG5 SPHK2 ADGRG3 EPHA6 GPRC5C CLDN3 ADGRF3 OR56A4 ADGRD1 OR51F1

8.68e-0413537113GO:0004888
GeneOntologyMolecularFunctionchloride:bicarbonate antiporter activity

SLC26A3 SLC26A4

9.48e-0413712GO:0140900
GeneOntologyMolecularFunctionbicarbonate:monoatomic anion antiporter activity

SLC26A3 SLC26A4

9.48e-0413712GO:0140829
GeneOntologyMolecularFunctiontransmembrane-ephrin receptor activity

EPHB6 EPHA6

1.27e-0315712GO:0005005
GeneOntologyMolecularFunctionheparan sulfate sulfotransferase activity

HS3ST3B1 HS3ST3A1

1.27e-0315712GO:0034483
GeneOntologyMolecularFunctionsulfate transmembrane transporter activity

SLC26A3 SLC26A4

1.45e-0316712GO:0015116
GeneOntologyCellularComponentbeta-catenin-TCF complex

TLE1 TLE3 TLE4

1.09e-0513723GO:1990907
Domain-

SORT1 SCAP WDR75 WDR97 EML4 STXBP5 TLE1 TLE2 TLE3 TLE4 NEDD1 WDR49 WDR77 PALB2

1.96e-1133370142.130.10.10
DomainWD40/YVTN_repeat-like_dom

SORT1 SCAP WDR75 WDR97 EML4 STXBP5 TLE1 TLE2 TLE3 TLE4 NEDD1 WDR49 WDR77 PALB2

2.13e-113357014IPR015943
DomainWD40_repeat_CS

SCAP WDR97 EML4 STXBP5 TLE1 TLE2 TLE3 TLE4 NEDD1 WDR49 WDR77

2.36e-111647011IPR019775
DomainWD_REPEATS_1

SCAP WDR75 WDR97 EML4 STXBP5 TLE1 TLE2 TLE3 TLE4 NEDD1 WDR49 WDR77 PALB2

2.96e-112787013PS00678
DomainWD_REPEATS_2

SCAP WDR75 WDR97 EML4 STXBP5 TLE1 TLE2 TLE3 TLE4 NEDD1 WDR49 WDR77 PALB2

3.10e-112797013PS50082
DomainWD_REPEATS_REGION

SCAP WDR75 WDR97 EML4 STXBP5 TLE1 TLE2 TLE3 TLE4 NEDD1 WDR49 WDR77 PALB2

3.10e-112797013PS50294
DomainWD40_repeat_dom

SCAP WDR75 WDR97 EML4 STXBP5 TLE1 TLE2 TLE3 TLE4 NEDD1 WDR49 WDR77 PALB2

6.75e-112977013IPR017986
DomainWD40

SCAP WDR75 WDR97 EML4 STXBP5 TLE1 TLE2 TLE3 TLE4 NEDD1 WDR49 WDR77

2.04e-102597012PF00400
DomainWD40

SCAP WDR75 WDR97 EML4 STXBP5 TLE1 TLE2 TLE3 TLE4 NEDD1 WDR49 WDR77

3.03e-102687012SM00320
DomainWD40_repeat

SCAP WDR75 WDR97 EML4 STXBP5 TLE1 TLE2 TLE3 TLE4 NEDD1 WDR49 WDR77

3.59e-102727012IPR001680
DomainGroucho_enhance

TLE1 TLE2 TLE3 TLE4

9.02e-105704IPR009146
DomainTLE_N

TLE1 TLE2 TLE3 TLE4

9.02e-105704PF03920
DomainGroucho/TLE_N

TLE1 TLE2 TLE3 TLE4

9.02e-105704IPR005617
DomainGPS

ADGRG5 ADGRG3 ADGRF3 ADGRD1

7.71e-0634704SM00303
DomainGPS

ADGRG5 ADGRG3 ADGRF3 ADGRD1

8.68e-0635704PF01825
DomainGPS

ADGRG5 ADGRG3 ADGRF3 ADGRD1

9.73e-0636704PS50221
DomainGPS

ADGRG5 ADGRG3 ADGRF3 ADGRD1

1.09e-0537704IPR000203
DomainG_PROTEIN_RECEP_F2_1

ADGRG5 ADGRG3 ADGRF3 ADGRD1

1.49e-0540704PS00649
DomainGPCR_2_extracellular_dom

ADGRG5 ADGRG3 ADGRF3 ADGRD1

1.49e-0540704IPR001879
DomainG_PROTEIN_RECEP_F2_3

ADGRG5 ADGRG3 ADGRF3 ADGRD1

1.49e-0540704PS50227
DomainG_PROTEIN_RECEP_F2_2

ADGRG5 ADGRG3 ADGRF3 ADGRD1

3.66e-0550704PS00650
Domain7tm_2

ADGRG5 ADGRG3 ADGRF3 ADGRD1

3.66e-0550704PF00002
DomainGPCR_2_secretin-like

ADGRG5 ADGRG3 ADGRF3 ADGRD1

7.53e-0560704IPR000832
DomainGPCR_2-like

ADGRG5 ADGRG3 ADGRF3 ADGRD1

7.53e-0560704IPR017981
DomainG_PROTEIN_RECEP_F2_4

ADGRG5 ADGRG3 ADGRF3 ADGRD1

8.04e-0561704PS50261
DomainGPR1/GPR3/GPR5

ADGRG5 ADGRG3

8.27e-054702IPR003910
DomainPrefoldin

TLE1 TLE2 TLE3 TLE4

1.54e-0472704IPR009053
DomainS04_transporter_CS

SLC26A3 SLC26A4

2.87e-047702IPR018045
DomainSLC26A

SLC26A3 SLC26A4

6.11e-0410702PS01130
DomainSTAS

SLC26A3 SLC26A4

7.45e-0411702PS50801
DomainSTAS_dom

SLC26A3 SLC26A4

7.45e-0411702IPR002645
DomainSLC26A/SulP_dom

SLC26A3 SLC26A4

7.45e-0411702IPR011547
DomainSTAS

SLC26A3 SLC26A4

7.45e-0411702PF01740
DomainSLC26A/SulP_fam

SLC26A3 SLC26A4

7.45e-0411702IPR001902
Domain-

SLC26A3 SLC26A4

7.45e-04117023.30.750.24
DomainSulfate_transp

SLC26A3 SLC26A4

7.45e-0411702PF00916
DomainRECEPTOR_TYR_KIN_V_2

EPHB6 EPHA6

1.22e-0314702PS00791
DomainRECEPTOR_TYR_KIN_V_1

EPHB6 EPHA6

1.22e-0314702PS00790
DomainEph_TM

EPHB6 EPHA6

1.22e-0314702IPR027936
DomainTyr_kinase_rcpt_V_CS

EPHB6 EPHA6

1.22e-0314702IPR001426
DomainEPH_lbd

EPHB6 EPHA6

1.22e-0314702SM00615
DomainEphrin_lbd

EPHB6 EPHA6

1.22e-0314702PF01404
DomainEphA2_TM

EPHB6 EPHA6

1.22e-0314702PF14575
DomainTyr_kinase_ephrin_rcpt

EPHB6 EPHA6

1.22e-0314702IPR016257
DomainEphrin_rcpt_lig-bd_dom

EPHB6 EPHA6

1.22e-0314702IPR001090
DomainEPH_LBD

EPHB6 EPHA6

1.22e-0314702PS51550
DomainIg-like_fold

EPHB6 HSPG2 EPHA6 SIGLEC6 MYOM3 HLA-G PKHD1 ADGRF3 LRIT1

1.24e-03706709IPR013783
Domain-

EPHB6 EPHA6 CUL7

2.60e-03737032.60.120.260
Domainfn3

EPHB6 EPHA6 MYOM3 LRIT1

3.21e-03162704PF00041
Domain-

EPHB6 HSPG2 EPHA6 SIGLEC6 MYOM3 HLA-G PKHD1 LRIT1

3.28e-036637082.60.40.10
DomainEphrin_rec_like

EPHB6 EPHA6

3.93e-0325702SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

EPHB6 EPHA6

3.93e-0325702IPR011641
DomainFN3

EPHB6 EPHA6 MYOM3 LRIT1

5.14e-03185704SM00060
DomainGalactose-bd-like

EPHB6 EPHA6 CUL7

5.30e-0394703IPR008979
DomainIg_I-set

HSPG2 SIGLEC6 MYOM3 LRIT1

5.64e-03190704IPR013098
Domainig

HSPG2 SIGLEC6 MYOM3 LRIT1

5.64e-03190704PF00047
DomainImmunoglobulin

HSPG2 SIGLEC6 MYOM3 LRIT1

5.64e-03190704IPR013151
DomainI-set

HSPG2 SIGLEC6 MYOM3 LRIT1

5.64e-03190704PF07679
DomainFN3

EPHB6 EPHA6 MYOM3 LRIT1

6.63e-03199704PS50853
DomainGPCR_2_secretin-like_CS

ADGRF3 ADGRD1

7.19e-0334702IPR017983
DomainFN3_dom

EPHB6 EPHA6 MYOM3 LRIT1

7.86e-03209704IPR003961
DomainSulfotransferase_dom

HS3ST3B1 HS3ST3A1

8.03e-0336702IPR000863
DomainSulfotransfer_1

HS3ST3B1 HS3ST3A1

8.03e-0336702PF00685
PathwayREACTOME_REPRESSION_OF_WNT_TARGET_GENES

TLE1 TLE2 TLE3 TLE4

5.70e-0810594MM15156
PathwayREACTOME_REPRESSION_OF_WNT_TARGET_GENES

TLE1 TLE2 TLE3 TLE4

2.68e-0714594M27402
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

TLE1 TLE2 TLE3 TLE4

3.86e-0626594MM14793
PathwayREACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX

TLE1 TLE2 TLE3 TLE4

9.12e-0632594MM14975
PathwayREACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX

TLE1 TLE2 TLE3 TLE4

2.75e-0542594M27272
PathwayREACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

TLE1 TLE2 TLE3 TLE4

4.69e-0548594M611
PathwayREACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM

XYLT1 HSPG2 HS3ST3B1 HS3ST3A1

9.26e-0557594M692
PathwayKEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE

XYLT1 HS3ST3B1 HS3ST3A1

1.69e-0426593M7330
PathwayREACTOME_SIGNALING_BY_NOTCH1

TLE1 TLE2 TLE3 TLE4

2.56e-0474594M616
PathwayREACTOME_HS_GAG_BIOSYNTHESIS

HSPG2 HS3ST3B1 HS3ST3A1

2.88e-0431593M685
PathwayREACTOME_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX

TLE1 TLE2 TLE3 TLE4

3.29e-0479594MM14754
PathwayREACTOME_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX

TLE1 TLE2 TLE3 TLE4

4.35e-0485594M27079
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

TLE1 TLE2 TLE3 TLE4

5.64e-0491594M27101
PathwayREACTOME_MULTIFUNCTIONAL_ANION_EXCHANGERS

SLC26A3 SLC26A4

6.08e-049592M27344
PathwayREACTOME_MULTIFUNCTIONAL_ANION_EXCHANGERS

SLC26A3 SLC26A4

6.08e-049592MM15084
PathwayWP_GLYCOSAMINOGLYCAN_SYNTHESIS_IN_FIBROBLASTS

XYLT1 HS3ST3B1 HS3ST3A1

6.63e-0441593M48095
Pubmed

TLE expression correlates with mouse embryonic segmentation, neurogenesis, and epithelial determination.

TLE1 TLE2 TLE3 TLE4

1.79e-1147348645603
Pubmed

Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins.

TLE1 TLE2 TLE3 TLE4

8.91e-1157341303260
Pubmed

Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein.

TLE1 TLE2 TLE3 TLE4

8.91e-1157348365415
Pubmed

Protein characterization and targeted disruption of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex.

TLE1 TLE2 TLE3 TLE4

2.67e-1067348573724
Pubmed

A Gro/TLE-NuRD corepressor complex facilitates Tbx20-dependent transcriptional repression.

TLE1 TLE2 TLE3 TLE4

6.22e-10773424024827
Pubmed

The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1.

TLE1 TLE2 TLE3 TLE4

1.24e-09873416002402
Pubmed

Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling.

TLE1 TLE2 TLE3 TLE4

1.24e-09873420735826
Pubmed

Spatial distribution of the full-length members of the Grg family during embryonic neurogenesis reveals a "Grg-mediated repression map" in the mouse telencephalon.

TLE1 TLE2 TLE3 TLE4

3.71e-091073430571765
Pubmed

Coexpression of Cux-1 and Notch signaling pathway components during kidney development.

TLE1 TLE2 TLE3 TLE4

5.83e-091173415499562
Pubmed

All Tcf HMG box transcription factors interact with Groucho-related co-repressors.

TLE1 TLE2 TLE3 TLE4

8.73e-091273411266540
Pubmed

Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia.

TLE1 TLE2 TLE3

8.87e-0937338808280
Pubmed

Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity.

TLE1 TLE3 TLE4

8.87e-09373330045946
Pubmed

Neurog2 simultaneously activates and represses alternative gene expression programs in the developing neocortex.

TLE1 TLE2 TLE3 TLE4

1.26e-081373422735158
Pubmed

Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.

TLE1 TLE2 TLE3 TLE4

1.76e-081473417202186
Pubmed

Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway.

TLE1 TLE2 TLE3 TLE4

2.40e-08157349291577
Pubmed

Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube.

TLE1 TLE3 TLE4

3.54e-08473311290324
Pubmed

Groucho co-repressor proteins regulate β cell development and proliferation by repressing Foxa1 in the developing mouse pancreas.

TLE1 TLE2 TLE3 TLE4

5.34e-081873433658226
Pubmed

Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis.

TLE1 TLE2 TLE3 TLE4

5.34e-081873411731482
Pubmed

Grg3, a murine Groucho-related gene, is expressed in the developing nervous system and in mesenchyme-induced epithelial structures.

TLE1 TLE3 TLE4

8.84e-0857338989517
Pubmed

Transcripts of Grg4, a murine groucho-related gene, are detected in adjacent tissues to other murine neurogenic gene homologues during embryonic development.

TLE1 TLE3 TLE4

1.77e-0767338892234
Pubmed

Expression of Groucho/TLE proteins during pancreas development.

TLE1 TLE2 TLE3 TLE4

1.84e-072473418778483
Pubmed

The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.

ADGRG5 ADGRG3 ADGRF3 ADGRD1

4.08e-072973415203201
Pubmed

A comparison of Notch, Hes and Grg expression during murine embryonic and post-natal development.

TLE1 TLE3 TLE4

4.93e-07873310512199
Pubmed

Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions.

ADGRG5 ADGRG3 ADGRF3

4.93e-07873312435584
Pubmed

Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9.

TLE1 TLE3 TLE4

4.93e-07873328296634
Pubmed

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.

ADGRG5 ADGRG3 ADGRF3 ADGRD1

6.98e-073373425713288
Pubmed

Gro/TLE enables embryonic stem cell differentiation by repressing pluripotent gene expression.

TLE3 TLE4

4.35e-06273225446531
Pubmed

TLE3 and TLE4-coordinated colonic macrophage-CD4+ T cell crosstalk maintains intestinal immune homeostasis.

TLE3 TLE4

4.35e-06273236801171
Pubmed

A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry.

HS3ST3B1 HS3ST3A1

4.35e-06273210520990
Pubmed

Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1.

HS3ST3B1 HS3ST3A1

4.35e-06273215304505
Pubmed

Genetic variations in genes involved in heparan sulphate biosynthesis are associated with Plasmodium falciparum parasitaemia: a familial study in Burkina Faso.

HS3ST3B1 HS3ST3A1

4.35e-06273222475533
Pubmed

Combinatorial expression patterns of individual TLE proteins during cell determination and differentiation suggest non-redundant functions for mammalian homologs of Drosophila Groucho.

TLE1 TLE4

4.35e-0627329572356
Pubmed

Groucho/TLE family proteins and transcriptional repression.

TLE1 TLE3

4.35e-06273210831834
Pubmed

Focal Adhesion Kinase-Dependent Role of the Soluble Form of Neurotensin Receptor-3/Sortilin in Colorectal Cancer Cell Dissociation.

SORT1 PTK2

4.35e-06273227834811
Pubmed

Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.

TLE1 TLE3

4.35e-06273233571907
Pubmed

Transcriptional regulation of cortical neuron migration by POU domain factors.

TLE1 TLE3 TLE4

9.86e-062073311859196
Pubmed

Assignment of a locus for autosomal dominant idiopathic scoliosis (IS) to human chromosome 17p11.

HS3ST3B1 HS3ST3A1

1.30e-05373212384783
Pubmed

Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.

TLE1 TLE4

1.30e-05373218258796
Pubmed

Molecular analysis of human solute carrier SLC26 anion transporter disease-causing mutations using 3-dimensional homology modeling.

SLC26A3 SLC26A4

1.30e-05373228941661
Pubmed

Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.

HSPG2 HS3ST3B1 HS3ST3A1

1.74e-052473334653670
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

HSPG2 SPHK2 TRAF4 SCAP ACACA SBF1 XPO6 MYOM3 CLDN3 TTYH3 NCLN

1.86e-051105731135748872
Pubmed

The G protein-coupled receptor repertoires of human and mouse.

ADGRG5 ADGRG3 ADGRF3 ADGRD1

2.38e-057973412679517
Pubmed

Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development.

TLE1 TLE2

2.60e-0547329874198
Pubmed

Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms.

TLE1 TLE2

2.60e-0547329854018
Pubmed

Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation.

TLE1 TLE2

2.60e-05473215768032
Pubmed

Biosynthesis of heparin/heparan sulfate. The D-glucosaminyl 3-O-sulfotransferase reaction: target and inhibitor saccharides.

HS3ST3B1 HS3ST3A1

2.60e-0547327744762
Pubmed

Dynamic expression of Groucho-related genes Grg1 and Grg3 in foregut endoderm and antagonism of differentiation.

TLE1 TLE3

2.60e-05473220108349
Pubmed

Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells.

SORT1 KLHDC3

2.60e-05473212482870
Pubmed

Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities.

HS3ST3B1 HS3ST3A1

2.60e-0547329988768
Pubmed

The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3.

TLE1 TLE2

2.60e-0547329334241
Pubmed

Corepressors TLE1 and TLE3 interact with HESX1 and PROP1.

TLE1 TLE3

2.60e-05473220181723
Pubmed

PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins.

TLE1 TLE2

2.60e-0547329887105
Pubmed

A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression.

TLE1 TLE3

2.60e-05473212397081
Pubmed

Modulation of Tcf3 repressor complex composition regulates cdx4 expression in zebrafish.

TLE1 TLE3

2.60e-05473221666599
Pubmed

CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.

TLE1 TLE2 TLE3

2.80e-052873317041588
Pubmed

The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription.

TLE1 TLE3

4.33e-05573211238932
Pubmed

Mutational analysis of genes with ureteric progenitor cell-specific expression in branching morphogenesis of the mouse kidney.

HS3ST3B1 HS3ST3A1

4.33e-05573232017326
Pubmed

Epigenetic mechanisms of Groucho/Grg/TLE mediated transcriptional repression.

TLE4 WDR77

4.33e-05573222169276
Pubmed

Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.

TLE1 TLE3

4.33e-05573210748198
Pubmed

Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger.

SLC26A3 SLC26A4

6.48e-05673211087667
Pubmed

Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9.

SLC26A3 SLC26A4

6.48e-05673211834742
Pubmed

Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation.

TLE1 TLE4

9.06e-05773216314515
Pubmed

Six3 and Six6 activity is modulated by members of the groucho family.

TLE1 TLE3

1.21e-04873212441302
Pubmed

Physiological roles and regulation of mammalian sulfate transporters.

SLC26A3 SLC26A4

1.55e-04973211581495
Pubmed

Neural-specific deletion of the focal adhesion adaptor protein paxillin slows migration speed and delays cortical layer formation.

TLE4 PTK2

1.55e-04973228935710
Pubmed

Disrupted development of the cerebral hemispheres in transgenic mice expressing the mammalian Groucho homologue transducin-like-enhancer of split 1 in postmitotic neurons.

TLE1 TLE4

1.93e-041073210781944
Pubmed

N-glycosylation and topology of the human SLC26 family of anion transport membrane proteins.

SLC26A3 SLC26A4

1.93e-041073224647542
Pubmed

Grg3/TLE3 and Grg1/TLE1 induce monohormonal pancreatic β-cells while repressing α-cell functions.

TLE1 TLE3

1.93e-041073224487024
Pubmed

Rho-family GTPase 1 (Rnd1) is a biomechanical stress-sensitive activator of cardiomyocyte hypertrophy.

MYOM3 NEDD1

1.93e-041073230797814
Pubmed

Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53.

TOPBP1 CUL7

2.36e-041173231570706
Pubmed

Identification of a candidate gene for astigmatism.

XYLT1 DNAH5

2.36e-041173223322567
Pubmed

Pitx3 and En1 determine the size and molecular programming of the dopaminergic neuronal pool.

TLE3 TLE4

2.36e-041173228800615
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

ACACA TLE1 TLE3 TLE4 JMJD1C PALB2

2.51e-0441873634709266
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

UBXN4 AFAP1 WDR75 SBF1 HLA-G TOPBP1 IST1 PRKAR2A GPRC5C CLDN3 WDR77

2.77e-041497731131527615
Pubmed

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.

UBXN4 TOPBP1 NABP1 PALB2

3.41e-0415773430686591
Pubmed

Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.

TLE4 PALB2

3.89e-041473221254220
Pubmed

Molecular characterization of the mouse superior lateral parabrachial nucleus through expression of the transcription factor Runx1.

TLE1 TLE4

3.89e-041473221085653
Pubmed

Deletion of astroglial connexins weakens the blood-brain barrier.

HSPG2 CLDN3

3.89e-041473222472609
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

SORT1 XYLT1 HK3 TLE1 TLE3 TLE4 CUL7 JMJD1C

4.30e-0485773825609649
Pubmed

Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.

UBXN4 IST1 NCLN WDR77

5.03e-0417473432149426
Pubmed

Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci.

HS3ST3B1 HS3ST3A1

5.12e-04167329988767
Pubmed

Disruption of segmental neural crest migration and ephrin expression in delta-1 null mice.

EPHB6 EPHA6

5.79e-041773212217323
Pubmed

Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning.

TLE2 CLDN3

5.79e-041773221924257
Pubmed

Integrator3, a partner of single-stranded DNA-binding protein 1, participates in the DNA damage response.

ACACA NABP1

5.79e-041773219759019
Pubmed

FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands.

HS3ST3B1 HS3ST3A1

6.51e-041873224924191
Pubmed

The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and β-cell differentiation.

TLE1 TLE3

6.51e-041873222434868
Pubmed

TCF and Groucho-related genes influence pituitary growth and development.

TLE3 TLE4

6.51e-041873212907761
Pubmed

Focal adhesion kinase is required for neural crest cell morphogenesis during mouse cardiovascular development.

HSPG2 PTK2

6.51e-041873219587446
Pubmed

Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation.

HSPG2 HS3ST3B1 HS3ST3A1

6.73e-048173339217171
Pubmed

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

TLE1 TLE3 JMJD1C

7.23e-048373328794006
Pubmed

The protein tyrosine kinase family of the human genome.

EPHB6 EPHA6 PTK2

7.23e-048373311114734
Pubmed

Expression of Ephs and ephrins in developing mouse inner ear.

EPHB6 EPHA6

7.26e-041973212684176
Pubmed

Genetic mapping of 20 novel expressed sequence tags from midgestation mouse embryos suggests chromosomal clustering.

TLE1 TLE4

7.26e-04197329070936
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

SORT1 ARFGEF3 ARL6IP6 SCAP XPO6 PRKAR2A GPRC5C NCLN

7.99e-0494273831073040
Pubmed

Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.

EPHB6 EPHA6

8.89e-04217329267020
Pubmed

TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons.

TLE4 HS3ST3B1

8.89e-042173227668656
Pubmed

Eph receptors and ephrins demarcate cerebellar lobules before and during their formation.

EPHB6 EPHA6

8.89e-042173210495276
Pubmed

Developmental expression of Eph and ephrin family genes in mammalian small intestine.

EPHB6 EPHA6

8.89e-042173220112066
Pubmed

Roles of Eph receptors and ephrins in segmental patterning.

EPHB6 EPHA6

8.89e-042173211128993
Pubmed

Eph receptors and ephrins: regulators of guidance and assembly.

EPHB6 EPHA6

8.89e-042173210730216
InteractionRIPPLY2 interactions

TLE1 TLE2 TLE3 TLE4

5.85e-0720694int:RIPPLY2
InteractionSIX6 interactions

TLE1 TLE3 TLE4

6.21e-0611693int:SIX6
InteractionHLX interactions

TLE1 TLE2 TLE3 TLE4

7.63e-0637694int:HLX
InteractionTLE4 interactions

TLE1 TLE2 TLE3 TLE4 WDR77

1.59e-0592695int:TLE4
InteractionRIPPLY1 interactions

TLE1 TLE2 TLE3 TLE4

3.76e-0555694int:RIPPLY1
InteractionSIX3 interactions

TLE1 TLE3 TLE4

4.20e-0520693int:SIX3
InteractionTBX20 interactions

TLE1 TLE3 TLE4

4.89e-0521693int:TBX20
CytobandEnsembl 112 genes in cytogenetic band chr16p12

XYLT1 XPO6 PALB2 ACSM2B

1.78e-04172744chr16p12
Cytoband8q24.3

WDR97 MROH5 PTK2

8.29e-041137438q24.3
Cytoband7q31

SLC26A3 SLC26A4

8.76e-04277427q31
Cytoband16p12.3

XYLT1 ACSM2B

1.39e-033474216p12.3
Cytoband16q21

ADGRG5 ADGRG3

2.43e-034574216q21
Cytoband1p13.2

PPM1J WDR77

2.53e-03467421p13.2
Cytoband17p12

HS3ST3B1 HS3ST3A1

2.87e-034974217p12
CytobandEnsembl 112 genes in cytogenetic band chr9q21

TLE1 TLE4 APBA1

4.15e-03199743chr9q21
CytobandEnsembl 112 genes in cytogenetic band chr17p12

HS3ST3B1 HS3ST3A1

4.84e-0364742chr17p12
CytobandEnsembl 112 genes in cytogenetic band chr1p13

SORT1 PPM1J WDR77

4.88e-03211743chr1p13
Cytoband19p13.3

TLE2 NCLN CNN2

6.73e-0323774319p13.3
CytobandEnsembl 112 genes in cytogenetic band chr16q21

ADGRG5 ADGRG3

7.29e-0379742chr16q21
Cytoband6p21.1

KLHDC3 CUL7

7.47e-03807426p21.1
GeneFamilyWD repeat domain containing

SCAP WDR75 WDR97 EML4 STXBP5 TLE1 TLE2 TLE3 TLE4 NEDD1 WDR49 WDR77

1.68e-112625512362
GeneFamilyAdhesion G protein-coupled receptors, subfamily G

ADGRG5 ADGRG3

1.89e-047552917
GeneFamilyFibronectin type III domain containing|Sterile alpha motif domain containing|EPH receptors

EPHB6 EPHA6

8.08e-04145521095
GeneFamilyFibronectin type III domain containing

EPHB6 EPHA6 MYOM3 LRIT1

1.42e-03160554555
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

HSPG2 SIGLEC6 MYOM3 LRIT1

1.45e-03161554593
GeneFamilySulfotransferases, membrane bound

HS3ST3B1 HS3ST3A1

5.65e-0337552763
CoexpressionGSE17721_CPG_VS_GARDIQUIMOD_0.5H_BMDC_UP

TRAF4 EPHA6 WDR75 KLHDC3 CLDN3 NABP1

1.69e-05199716M3876
CoexpressionGSE40274_FOXP3_VS_FOXP3_AND_GATA1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN

CACNA1A TRAF4 ADGRG3 XPO6 TLE1 TTYH3

1.69e-05199716M9180
CoexpressionGSE15735_CTRL_VS_HDAC_INHIBITOR_TREATED_CD4_TCELL_12H_DN

EPHB6 ADGRG5 ADGRG3 STXBP5 PPM1J CNN2

1.74e-05200716M7157
ToppCellCOVID-19-Lymphoid-pDC|COVID-19 / Condition, Lineage and Cell class

ADGRG5 HSPG2 TRAF4 SIGLEC6 BSPRY GPRC5C PPM1J

3.15e-0819174725343b11d42128ad16659e5519cd1673266cc505
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 EPHA6 BSPRY PKHD1 CLDN3 WDR49

6.14e-07183746c5b10571599dc26476170b54b53f09c23e6b3117
ToppCellsaliva-Severe-critical_progression_d28-40|saliva / Compartment, severity and other cell annotations on 10x 3' data (130k)

ADGRG3 XPO6 TLE3 NABP1 JMJD1C CNN2

6.75e-071867460095560ca776b01aa473ad4d6015ed78fc93ff51
ToppCellPCW_05-06-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 EPHA6 BSPRY PKHD1 CLDN3 WDR49

7.42e-07189746c8b8f860aaf6c73863cd79941db6b469c830ef06
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 EPHA6 PKHD1 CLDN3 DNAH5 WDR49

7.89e-0719174660ff989fe99d243a3d52955223680cdd1f1917a4
ToppCellPCW_05-06-Epithelial-Epithelial_airway|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 EPHA6 BSPRY PKHD1 CLDN3 WDR49

8.38e-07193746af6ec2c2ba92aef3e41531c3c7215b3300437bd9
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 EPHA6 BSPRY PKHD1 CLDN3 WDR49

8.64e-07194746b19e16a76d7342ff9a665d19c9151652916f17d4
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 EPHA6 PKHD1 CLDN3 DNAH5 WDR49

8.64e-07194746f95c8dc242c9aebcadfe61b1ed033349cb7e5a88
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRG5 BSPRY NABP1 HS3ST3B1 PPM1J

7.96e-061647459fed5df40f50bde35db8bf89c291cbdc0e104112
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRG5 BSPRY NABP1 HS3ST3B1 PPM1J

7.96e-06164745e712d6b89461f741dbd773ba9a27ecaddf97cbaa
ToppCell(3)_MNP-(3)_DC_plasmacytoid|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)

ADGRG5 TRAF4 SIGLEC6 BSPRY PPM1J

8.95e-0616874513c160ea1a19b47d2e7e2dae818c8dcde4e3e377
ToppCellCOVID_vent-Lymphocytic-Dendritic-pDC|COVID_vent / Disease condition, Lineage, Cell class and subclass

ADGRG5 TRAF4 SIGLEC6 HS3ST3B1 PPM1J

9.75e-06171745779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCellCOVID_vent-Lymphocytic-Dendritic|COVID_vent / Disease condition, Lineage, Cell class and subclass

ADGRG5 TRAF4 SIGLEC6 HS3ST3B1 PPM1J

9.75e-06171745debbb071d260639b16269c94d172766908325c58
ToppCellsystemic_lupus_erythematosus-treated-Myeloid-plasmacytoid_dendritic_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TRAF4 SIGLEC6 BSPRY GPRC5C PPM1J

1.32e-051827459bbe8062aa562dc3b9c299581faf6ebbcb72a9f7
ToppCellsystemic_lupus_erythematosus-treated-Myeloid-plasmacytoid_dendritic_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TRAF4 SIGLEC6 BSPRY GPRC5C PPM1J

1.32e-051827454602a98df7045e2c70b7560abfba9b444fbd5d30
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CACNA1A SLC26A4 SLC51A HS3ST3A1 PPM1J

1.35e-051837452dde2fb48e7d31271c2f6b1dd74b2ab0b2cb520c
ToppCelldroplet-Large_Intestine|droplet / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC26A3 BSPRY CLDN3 SLC51A HEPH

1.35e-051837459d7ffcb9804b9a52448ccb56c9370b317a4b52a5
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SORT1 APBA1 HS3ST3B1 HS3ST3A1 WDR49

1.35e-051837453c516fe5083f02bad1f464ed284010b4131a833c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SORT1 APBA1 HS3ST3B1 HS3ST3A1 WDR49

1.35e-051837459c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ADGRG3 HK3 EPHA6 XPO6 DNAH5

1.39e-051847457ecdf2645e9378cf2f5ce4557f2cf100e6f184ba
ToppCell(7)_MNP-(7)_DC_plasmacytoid|(7)_MNP / Spleen cell shreds - cell class (v1) and cell subclass (v1)

ADGRG5 TRAF4 BSPRY HS3ST3B1 PPM1J

1.43e-051857459f67f652488e17075a372e2a2e1100f6d0af6d7d
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

ARFGEF3 ACACA SLC26A4 DNAH5 PTK2

1.43e-05185745cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellcontrol-Myeloid-pDC|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ADGRG5 TRAF4 SIGLEC6 BSPRY PPM1J

1.46e-05186745fe31e9cf4575ee40b50489593c51d8c36c3cc532
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 CACNA1A ADGRG5 BSPRY TMEM176A

1.46e-05186745c7983281a290201567b398e9ea6baddb96c692bb
ToppCellcontrol-Myeloid-pDC|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ADGRG5 TRAF4 SIGLEC6 BSPRY PPM1J

1.46e-05186745fccee4cfcc887358cf916d974f29627095b5ad9c
ToppCell10x5'v1-week_14-16-Myeloid_DC-DC-pDC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ADGRG5 TRAF4 SIGLEC6 GPRC5C PPM1J

1.50e-05187745bf64a6ef5062ec9a0f7095e8c97ce66bfc3bf179
ToppCellCOVID-19-kidney-Mito-rich_PCT|kidney / Disease (COVID-19 only), tissue and cell type

SLC26A3 MYOM3 PKHD1 TTYH3 ACSM2B

1.50e-05187745738ec2611b4be6a08eedad16b57fba84e1f11fef
ToppCellcontrol-pDC|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TRAF4 BSPRY GPRC5C HS3ST3B1 PPM1J

1.50e-05187745c78aee98b32719aa45811b620fc97be1ecf5fd53
ToppCell(0)_Myeloid-(011)_pDC|(0)_Myeloid / immune cells in Peripheral Blood (logTPM normalization)

ADGRG5 TRAF4 BSPRY HS3ST3B1 PPM1J

1.54e-05188745a81b5d840490d6a636fe168f8cff2c4984369f09
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 EPHA6 BSPRY PKHD1 CLDN3

1.54e-051887453cfba3addcc9058f4ec31ad96261f79988f551a0
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 EPHA6 PKHD1 CLDN3 WDR49

1.58e-051897457659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCellcontrol-Myeloid-Neutrophils_1|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ADGRG3 XPO6 TLE3 NABP1 JMJD1C

1.66e-05191745db1b3cd07d7d190155b2d14e82e1d124975fbd0b
ToppCellPCW_05-06-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 EPHA6 BSPRY PKHD1 CLDN3

1.66e-0519174505731ece7867659c662f952812805f947032fe10
ToppCellControl-pDC|Control / Disease condition and Cell class

ADGRG5 TRAF4 BSPRY HS3ST3B1 PPM1J

1.66e-05191745543e1437a52d04436862dd1c27b4fae95c44fcc8
ToppCellControl-pDC-|Control / Disease condition and Cell class

ADGRG5 TRAF4 BSPRY HS3ST3B1 PPM1J

1.66e-051917451d7b0fae4d114d6db933c18b4eb2066ffa61356d
ToppCellBAL-Severe-Myeloid-pDC-pDC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ADGRG5 TRAF4 SIGLEC6 BSPRY PPM1J

1.70e-05192745d9ff2293358c8b031ba212021012e058014ff472
ToppCellSevere_COVID-19-Myeloid-pDC|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

ADGRG5 TRAF4 SIGLEC6 BSPRY PPM1J

1.70e-05192745f79424c643a375dfe4579eff7ac1ba191e28a283
ToppCellBAL-Severe-Myeloid-pDC-pDC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ADGRG5 TRAF4 SIGLEC6 BSPRY PPM1J

1.70e-051927452e8611d65090e39f1a6e74c972288e7b68376d15
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 EPHA6 PKHD1 CLDN3 WDR49

1.70e-05192745b99f8236ef4ccdc75c02abea381cae6453205f6f
ToppCellBAL-Severe-Myeloid-pDC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ADGRG5 TRAF4 SIGLEC6 BSPRY PPM1J

1.70e-0519274543569726df281eebe57499e0993b9fd9d36118c2
ToppCellPCW_05-06-Epithelial-Epithelial_neuroendo|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 EPHA6 BSPRY PKHD1 CLDN3

1.75e-05193745aa10924b203c71e65fdbd2b90ba131dbd362d8b1
ToppCellcontrol-pDC|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TRAF4 BSPRY GPRC5C HS3ST3B1 PPM1J

1.75e-0519374530a6559c9a9e8941861cb259b4836acccc427e68
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 PKHD1 CLDN3 DNAH5 WDR49

1.79e-051947456b286992d4bb56013c0ea5a7601d3476d806175a
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ADGRG3 XPO6 TLE3 NABP1 JMJD1C

1.79e-05194745d2f6c8900b5c448eede8047ca964e94b19bd6ca5
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_naive-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ADGRG3 XPO6 TLE3 JMJD1C CNN2

1.93e-05197745d2b2eaa6f7294ff56b84a69c8727c7e0f9fd0466
ToppCellSepsis-ICU-SEP-Myeloid-pDC|ICU-SEP / Disease, condition lineage and cell class

TRAF4 SIGLEC6 GPRC5C HS3ST3B1 PPM1J

1.98e-05198745fe8a68bff8c1b9566eee4bfcab564f206a20ae7b
ToppCellmedial-2-Epithelial-Mucous|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ARFGEF3 BSPRY SLC26A4 GPRC5C SLC51A

2.02e-051997454737250b7ffa7cc19eb6b057d35d78f13b1afe66
ToppCellmedial-Epithelial-Mucous|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ARFGEF3 BSPRY SLC26A4 GPRC5C SLC51A

2.02e-051997454385963ab25b5378e7964b984028c25b27e5794e
ToppCelldistal-Epithelial-Mucous-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ARFGEF3 BSPRY SLC26A4 GPRC5C SLC51A

2.02e-051997450af89ef40807fc4ad79ab82a2186ab6e866c6931
ToppCellmedial-Epithelial-Mucous-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ARFGEF3 BSPRY SLC26A4 GPRC5C SLC51A

2.02e-0519974553198bcf5f2f012a3ed1600d95c0923d6976a099
ToppCellBronchial-10x5prime-Epithelial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ARFGEF3 TRAF4 GPRC5C CLDN3 DNAH5

2.07e-05200745d3ee5f79513e2ac02ad3329b59e6290d457c44d2
ToppCellmLN-Mast_cell-Mast|mLN / Region, Cell class and subclass

SORT1 SIGLEC6 BSPRY APBA1 TMEM176A

2.07e-0520074581ea6e7a3940277751faf9097b30198159998c7b
ToppCelldistal-Epithelial|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ARFGEF3 TRAF4 GPRC5C CLDN3 DNAH5

2.07e-052007450a97080f694738bb882787cee21b91a4d5757b7a
ToppCellmLN-Mast_cell|mLN / Region, Cell class and subclass

SORT1 SIGLEC6 BSPRY APBA1 TMEM176A

2.07e-052007459a5f1d99d8d160923d4d0fbbf9ad48a26f8a4fad
ToppCellmLN-(7)_Mast_cell-(70)_Mast|mLN / shred on region, Cell_type, and subtype

SORT1 SIGLEC6 BSPRY APBA1 TMEM176A

2.07e-05200745a6c258cae678be581b1d85cf3446c65c34b13499
ToppCellmLN-(7)_Mast_cell|mLN / shred on region, Cell_type, and subtype

SORT1 SIGLEC6 BSPRY APBA1 TMEM176A

2.07e-0520074513bca944fbdbc0be6687eca82c62a4d231ab94f0
ToppCellPBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_0|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ADGRG3 XPO6 MYOM3 PKHD1

6.16e-0512874458639cfdc70ff6764adcc5c1ce9eba9d033b8209
ToppCellPBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_0|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ADGRG3 XPO6 MYOM3 PKHD1

6.16e-051287449b3c57d559a5ed8d590dd89b64a57a3227d8c684
ToppCellPCW_05-06-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ADGRG3 PKHD1 CLDN3 DNAH5

8.73e-051407448abbd5dc799943b49cd0045d0da405c3f3d0db6b
ToppCellPCW_05-06-Epithelial-Epithelial_ciliated|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ADGRG3 PKHD1 CLDN3 DNAH5

8.73e-05140744e4689232c473d239b07a7fbcaaa3414fbd9badea
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SORT1 EPHA6 SLC26A4 MROH5

9.47e-051437445fb5a4ea93e5cce55d427e3b4a50a979504fad3c
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC26A3 EPHA6 PKHD1 ACSM2B

9.99e-0514574496712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellfacs-GAT-Fat-3m-Lymphocytic-NK_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BSPRY NABP1 HS3ST3B1 PPM1J

1.17e-041517443d07b79ecbcfad13116f0f2b039bd181a7ffe853
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRG5 BSPRY HS3ST3B1 PPM1J

1.39e-041587449f0987eaf1766aadb5714b68df7a5d310ea5a57a
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Lymphocytic-mature_NK_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRG5 HK3 HS3ST3B1 PPM1J

1.43e-0415974432d4c9f7ba6a96ce8443396b80568b41cbfc4927
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRG5 BSPRY HS3ST3B1 PPM1J

1.43e-0415974494bc6ab248a8f02ccbc0facd24e0c7e9fda687d2
ToppCellcellseq2-Epithelial-Epithelial_Neuro-Secretory-Ionocyte|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

XYLT1 EPHA6 HLA-G SLC51A

1.46e-041607449049707a4487f2337a17976ceb5fbd8815ab9e1d
ToppCellcellseq2-Epithelial-Epithelial_Neuro-Secretory-Ionocyte-Ionocyte|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

XYLT1 EPHA6 HLA-G SLC51A

1.46e-04160744f2cfec54cf48a655f473b830be7d141c54b521ff
ToppCellcellseq2-Epithelial-Epithelial_Neuro-Secretory|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

XYLT1 EPHA6 HLA-G SLC51A

1.46e-041607440eb50b3c494e1b65d40104b3b5411b57bb72b959
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC26A3 EPHA6 PKHD1 ACSM2B

1.53e-04162744bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellPCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

PKHD1 CLDN3 DNAH5 WDR49

1.64e-041657440c714e852f912b5749de4cb0895406673979b2e6
ToppCellPCW_07-8.5-Epithelial-Epithelial_ciliated|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

PKHD1 CLDN3 DNAH5 WDR49

1.64e-0416574482530f96aaefe28a13bad0474bbad043f127a86c
ToppCellsevere-Myeloid-pDC|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ADGRG5 TRAF4 SIGLEC6 PPM1J

1.68e-04166744ae38850fde549b8dd6fb12f0ef80b428ade50485
ToppCell10x5'v1-week_12-13-Myeloid_DC-DC-pDC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ADGRG5 GPRC5C HS3ST3B1 PPM1J

1.68e-041667449fa90d9d484563d44738bb2c6eb0775dffc4d549
ToppCell10x5'v1-week_17-19-Myeloid_DC-DC-DC1|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

WDR97 APBA1 PPM1J CNN2

1.80e-04169744488ba50631a64cb9e0d69219491c66ac824c9e7d
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARFGEF3 CACNA1A PKHD1 CLDN3

1.84e-04170744985c2d5962100fab0d95bee39f382ccbe799331e
ToppCell10x5'-blood-Myeloid_Dendritic-pDC|blood / Manually curated celltypes from each tissue

TRAF4 SIGLEC6 GPRC5C PPM1J

1.84e-0417074459cb1262ff319349d42b11afbec2a9035b7b79f2
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Enterocyte_(Proximal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC26A3 SLC51A PPM1J HEPH

1.88e-041717445d0d6c1ff610a703ae0b834a12823c5ff9012932
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Lymphocytic-mature_NK_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRG5 BSPRY SLC26A4 HS3ST3B1

1.88e-04171744562fc8a422615dbbece67ea49740f0c09bdb9ae3
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ADGRG3 XPO6 TLE3 CNN2

1.88e-041717442b7c5a557c4bc5c573211c4d618bdd6766a24916
ToppCellInfluenza_Severe-B_intermediate|World / Disease group and Cell class

CACNA1A TLE1 SIGLEC6 PTK2

1.88e-041717444d33e1dc1efc423dbdd5f4cca6d6440a68add8d0
ToppCelldroplet-Lung-1m-Hematologic-lymphocytic-mature_NK_T_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADGRG5 HS3ST3B1 PPM1J CNN2

1.88e-04171744a0462781d22c391b3c6c8a72586c385ac089ca5d
ToppCelldroplet-Lung-1m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l4|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADGRG5 HS3ST3B1 PPM1J CNN2

1.88e-0417174485b655dc8a3cbf0e8097e951116490e326a795ac
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ADGRG3 XPO6 TLE3 CNN2

1.88e-04171744dcb15bc54aeea06ef8f07f1134f3ff1e21ac0e4f
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-mature_NK_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRG5 HS3ST3B1 PPM1J CNN2

1.88e-04171744f12c2e48637b96557afbc2006a3a23ba21b7951e
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-Natural_Killer_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRG5 HS3ST3B1 PPM1J CNN2

1.88e-0417174412c98dea7370377695c5d22309f78ba03e282a0e
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nxph3|Hippocampus / BrainAtlas - Mouse McCarroll V32

XYLT1 TLE4 ADGRD1

1.90e-0467743b80bdd122a0284611161c40ec7a9c893dc8de4de
ToppCellCOVID-pDC|COVID / Condition, Cell_class and T cell subcluster

TRAF4 BSPRY PPM1J WDR49

1.93e-041727443ecbb000495dde32f6153ef6bdea9c8802ff3985
ToppCellmild_COVID-19-pDC|World / disease group, cell group and cell class (v2)

TRAF4 BSPRY GPRC5C PPM1J

1.93e-04172744dab2f1a05c7df58d9387b13271b3f1f1583f9ac3
ToppCellCOVID-pDC-|COVID / Condition, Cell_class and T cell subcluster

TRAF4 BSPRY PPM1J WDR49

1.93e-04172744a7827faa1afab51fdaf0cb1a2babcd2e00d411e5
ToppCellmild_COVID-19-pDC|mild_COVID-19 / disease group, cell group and cell class (v2)

TRAF4 BSPRY GPRC5C PPM1J

2.06e-04175744b87f279a7519710146c49d6acccb0adedc195965
ToppCellCOVID-19-kidney-Podocyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

APBA1 HS3ST3B1 HS3ST3A1 WDR49

2.06e-04175744a73e3a65fd5c1e09cb0c2dae20c1a7bfcae49223
ToppCellmild-Myeloid-pDC|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ADGRG5 TRAF4 BSPRY PPM1J

2.10e-0417674459a9c262c252b7d220a025837922d98e9d6b0a24
ToppCell10x3'2.3-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast-basophil|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

XYLT1 ADGRG3 HK3 GPRC5C

2.10e-04176744581d78811b2d99f38a2c7cc268aeb1cf932379c2
ToppCellfacs-Spleen-nan-18m-Lymphocytic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRG5 NABP1 HS3ST3B1 PPM1J

2.10e-04176744a23d484aff5ad094333b2feae9106ca219514711
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ARFGEF3 ACACA DNAH5 WDR49

2.10e-041767443bbac5c2397535631fce8fa98f6ddb4fe0260351
ToppCellmyeloid-Dendritic_cell-Plasmacytoid_dendritic_cell|myeloid / Lineage, cell class and subclass

ADGRG5 TRAF4 BSPRY PPM1J

2.20e-04178744f75591988bbbeba073b66329a3437cb9b02f7648
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_3|368C / Donor, Lineage, Cell class and subclass (all cells)

XPO6 TTYH3 CUL7 NCLN

2.20e-04178744536a601abcc60867949ea06e9aafb6c7b799b56b
ToppCellfacs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SORT1 BSPRY CLDN3 ADGRF3

2.20e-041787443d120458a0a56097532ebfa5fc6f77b52af2af2a
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TLE2 BSPRY HS3ST3B1 HS3ST3A1

2.24e-04179744cd7f0e8f4abb2a2bac366c8910c8c5fda841dbce
Diseaseneutrophil percentage of leukocytes

SPHK2 TLE4 BSPRY HLA-G NCLN JMJD1C CNN2

6.06e-04610707EFO_0007990
Diseaseneuritic plaque measurement

CACNA1A TLE4 HS3ST3B1 PTK2 ACSM2B

1.45e-03349705EFO_0006798
Diseasemyeloid white cell count

SPHK2 XPO6 STXBP5 TLE3 NABP1 NCLN JMJD1C CNN2

1.66e-03937708EFO_0007988
Diseaseergothioneine measurement

CACNA1A DNAH5

1.74e-0326702EFO_0021163
DiseaseCholestasis

SORT1 CFHR5 SLC51A

2.30e-03110703C0008370

Protein segments in the cluster

PeptideGeneStartEntry
LWALLTLFTVSTGEG

CACNA1A

1446

O00555
WGLGLATLLEEVSTV

ADGRF3

986

Q8IZF5
LAILGSTWVALTTGA

DPM3

11

Q9P2X0
STWVALTTGALGLEL

DPM3

16

Q9P2X0
GWIALSEDSAVVLSL

ADGRD1

336

Q6QNK2
RWIGILLAETGSSTD

AFAP1

431

Q8N556
AELRGGSWVVIDSSI

ACACA

2086

Q13085
VLTLLGLSSLVGVTW

ADGRG3

476

Q86Y34
DTGATWRTSGLLEEL

C18orf25

281

Q96B23
ELEVRTSTASGLLLW

HSPG2

4231

P98160
TSTASGLLLWQGVEV

HSPG2

4236

P98160
VSDWLIASVEGRLTG

NCLN

196

Q969V3
GWTLLGSDLILIVIS

OR56A4

206

Q8NGH8
LLLSGALTLTETWAG

HLA-G

11

P17693
AGLIDTSWSAIQIGI

HS3ST3B1

261

Q9Y662
SLLGSVSDNGIVTLW

NEDD1

176

Q8NHV4
WGGSEVISSLSNTIL

JMJD1C

1411

Q15652
VASWTLGSLDGIIVL

OR2M4

146

Q96R27
GLTVSSLSTTLGILW

OR51F1

81

A6NGY5
LLGVVSSWLEGAVLE

CUL7

1276

Q14999
AGLIDTSWSAIQIGI

HS3ST3A1

276

Q9Y663
DASLGTVLSVLWTGQ

PRR25

286

Q96S07
ASLRVLWVTLTGIEG

HK3

101

P52790
QEVSSDGTSWTLLGL

LRIT1

301

Q9P2V4
SSVLVGLEDGWDITT

SBF1

1416

O95248
NTEWLIITLVRGSGE

GPRC5C

171

Q9NQ84
GVSTLLALWTLGIIS

SLC51A

226

Q86UW1
ILTSGTIAIWDLLLG

PALB2

1131

Q86YC2
SDLLVGTASGSWLIS

OTOP1

391

Q7RTM1
QLWATAVLGSLSGTE

BSPRY

216

Q5W0U4
WALETLGGLDTIVKI

ARFGEF3

26

Q5TH69
ILGVVIVESGWGSIL

APBA1

666

Q02410
SVILISWVSTVGGEG

CFHR5

6

Q9BXR6
ELDSGLAESVSTLIW

IST1

91

P53990
STVLIDDTVLLWGGR

KLHDC3

81

Q9BQ90
IVATSEGSLWGLDRV

PRKAR2A

221

P13861
WDSVTLSTLQIIGLG

EML4

346

Q9HC35
SGLDDLISIWDRSTG

SCAP

1176

Q12770
WERITTLTGHSLDVG

DNAH5

1496

Q8TE73
LSTITDIDGIWEGIG

PNLIPRP2

261

P54317
LTWVGERGILVASDS

WDR77

86

Q9BQA1
VLLDTTTVLGELGWK

EPHA6

36

Q9UF33
SDLIWTAIDGLGSTS

MROH5

736

Q6ZUA9
SVSLSWVGDSTGVIL

SORT1

111

Q99523
TGSITISVWDEIGGL

NABP1

51

Q96AH0
TLLVTSGAAIWTGAV

TMEM176A

81

Q96HP8
ALGSSWIISVELAIG

PTK2

261

Q05397
LLDTTGETSEIGWLT

EPHB6

36

O15197
TVAWHLLGLGTETDV

HEPH

641

Q9BQS7
DVLVLGTDGLWDVTT

PPM1J

421

Q5JR12
GVLGAVWGASITTLV

SIGLEC6

346

O43699
TWITVIFDGLELGVL

PKHD1

36

P08F94
WATIRGSSLEGVSLI

PKHD1

1036

P08F94
EWLLSDIVSGISTGI

SLC26A3

71

P40879
LLIGFESGTVVLWDL

STXBP5

211

Q5T5C0
TVTVLGLTVLLGTTW

ADGRG5

456

Q8IZF4
SDTGWILNILGSLLE

ACSM2B

261

Q68CK6
VDTGLLGFWTLLIIS

ARL6IP6

146

Q8N6S5
EITGTALAVLGWLGT

CLDN3

6

O15551
EAELRTWIEGLTGLS

CNN2

31

Q99439
IVGGEASTLSIWDLA

TLE1

546

Q04724
ASTGTALEGWLDSLV

XYLT1

896

Q86Y38
QGLSLSEWDGIVTVS

SPHK2

231

Q9NRA0
KEWLLSDVISGVSTG

SLC26A4

81

O43511
RTLIVGGEASTLSIW

TLE4

546

Q04727
TSLLSGGRESVLVEW

WDR75

261

Q8IWA0
VVGHTDGTLSVLEWL

WDR97

571

A6NE52
RLLTGSTDGTVKIWD

WDR49

206

Q8IV35
LVVLLTLWITGGDGD

TMDD1

236

P0DPE3
TFWVVSVVLGSLLGL

SCART1

901

Q4G0T1
ELSVGSDGVLIWKIG

TRAF4

301

Q9BUZ4
TLIVGGEASTLTIWD

TLE3

546

Q04726
SSLEQWEILGTSSGE

nan

6

Q0VFX4
QTVLGLLTGILETVW

XPO6

181

Q96QU8
SSSGDIWTLLGTVLY

UBXN4

406

Q92575
VISWGALGLELAVSV

TTYH3

251

Q9C0H2
RSLIVGGEASTLSIW

TLE2

516

Q04725
WGSSSILDVLTGINV

TOPBP1

1351

Q92547
LEKSVIGSGTWEAIS

MYOM3

536

Q5VTT5