Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	CH	SYNE1 MAPRE2 PLS3	1.15e-03	70	55	3	PF00307
Domain	-	SYNE1 MAPRE2 PLS3	1.20e-03	71	55	3	1.10.418.10
Domain	CH	SYNE1 MAPRE2 PLS3	1.30e-03	73	55	3	PS50021
Domain	CH-domain	SYNE1 MAPRE2 PLS3	1.40e-03	75	55	3	IPR001715
Domain	Actinin_actin-bd_CS	SYNE1 PLS3	2.07e-03	23	55	2	IPR001589
Domain	Spectrin	DRP2 SYNE1	2.07e-03	23	55	2	PF00435
Domain	ACTININ_2	SYNE1 PLS3	2.07e-03	23	55	2	PS00020
Domain	ACTININ_1	SYNE1 PLS3	2.07e-03	23	55	2	PS00019
Domain	Spectrin_repeat	DRP2 SYNE1	3.29e-03	29	55	2	IPR002017
Domain	Spectrin/alpha-actinin	DRP2 SYNE1	3.99e-03	32	55	2	IPR018159
Domain	SPEC	DRP2 SYNE1	3.99e-03	32	55	2	SM00150
Domain	DNA/RNA_helicase_DEAH_CS	RECQL4 CHD3	4.76e-03	35	55	2	IPR002464
Domain	DEAH_ATP_HELICASE	RECQL4 CHD3	5.59e-03	38	55	2	PS00690
Domain	WW	DRP2 PLEKHA5	8.46e-03	47	55	2	PF00397
Domain	WW	DRP2 PLEKHA5	8.81e-03	48	55	2	SM00456
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	EPRS1 SLK RECQL4 PLEKHA5 CHD3 GALNT6 CMTR2 DIS3 POLR3A	1.06e-06	650	57	9	38777146
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	RABL6 GPD2 EPRS1 PTPN13 MYO9A RPS11 PLEKHA5 MAPRE2 PLS3	2.15e-06	708	57	9	39231216
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	EPRS1 SLK RPS11 PLEKHA5 CHD3 ZDBF2	3.97e-06	256	57	6	33397691
Pubmed	Set1/MLL complex is indispensable for the transcriptional ability of heat shock transcription factor 2.	SETD1A HSF2	7.91e-06	3	57	2	26478434
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CUL1 EPRS1 SETD1A MYO9A MCM3AP RECQL4 RPS11 PLEKHA5 MAPRE2 DIS3 POLR3A	1.05e-05	1353	57	11	29467282
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	GPD2 CUL1 EPRS1 SLK PITRM1 SYNE1 RPS11 STX16 DIS3 PLS3 POLR3A	1.71e-05	1425	57	11	30948266
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	GPD2 EPRS1 SLK MYO9A SYNE1 TTC21A RPS11 PLEKHA5 CHD3 GRIN1 PLS3	1.78e-05	1431	57	11	37142655
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	EPRS1 SETD1A HSF2	4.92e-05	43	57	3	33472061
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	CUL1 EPRS1 CTCF MCM3AP RPS11 CHD3 SENP5	9.51e-05	655	57	7	35819319
Pubmed	Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.	CUL1 EPRS1 RPS11 MAPRE2 CMTR2 DNAH14	1.10e-04	463	57	6	27503909
Pubmed	MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.	PTPN13 PLEKHA5 PLS3	1.15e-04	57	57	3	29089450
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	EPRS1 SLK PTPN13 CTCF RPS11 CHD3 MAPRE2 DIS3	1.35e-04	934	57	8	33916271
Pubmed	A human MAP kinase interactome.	MYO9A SYNE1 MCM3AP RAPGEF1 PLEKHA5 NEB	1.43e-04	486	57	6	20936779
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	EPRS1 TTC21A MCM3AP RECQL4 GRIN1 CPT1B DNAH14	1.95e-04	736	57	7	29676528
Pubmed	THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia.	TTC21A NKX2-2	2.73e-04	15	57	2	18327258
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	EPRS1 SETD1A SLK PTPN13 PLEKHA5 PLS3	2.76e-04	549	57	6	38280479
Pubmed	A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.	GPD2 IP6K2	3.12e-04	16	57	2	25082827
Pubmed	Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues.	CYP2B6 CPT1B	3.12e-04	16	57	2	22154759
Pubmed	Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness.	SYNE1 PREX1	3.53e-04	17	57	2	17903302
Pubmed	Fgf8 controls regional identity in the developing thalamus.	NKX2-2 FGF18	3.53e-04	17	57	2	18653561
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	PTPN13 MYO9A PLEKHA5 ZDBF2	3.90e-04	209	57	4	36779422
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	CUL1 MYO9A MCM3AP ZDBF2 HSF2 DIS3	3.98e-04	588	57	6	38580884
Pubmed	Interactome mapping defines BRG1, a component of the SWI/SNF chromatin remodeling complex, as a new partner of the transcriptional regulator CTCF.	CTCF RPS11 MAPRE2	4.43e-04	90	57	3	30459231
Pubmed	Overexpression of Truncated Human DISC1 Induces Appearance of Hindbrain Oligodendroglia in the Forebrain During Development.	NKX2-2 GRIN1	4.43e-04	19	57	2	28981898
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	CUL1 EPRS1 SLK RPS11 CHD3 PLS3 POLR3A	4.55e-04	847	57	7	35235311
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	SYNE1 PLEKHA5 PREX1 DIS3	5.15e-04	225	57	4	12168954
Pubmed	Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.	RABL6 SLK HSF2 PLS3	5.24e-04	226	57	4	31452512
Pubmed	Gene essentiality and synthetic lethality in haploid human cells.	EPRS1 SETD1A CTCF CMTR2	5.50e-04	229	57	4	26472760
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	KLHL5 OTOF SYNE1 NEB	5.97e-04	234	57	4	36243803
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	PTPN13 RPS11 PLEKHA5 CHD3 ZDBF2	6.14e-04	418	57	5	34709266
Pubmed	The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.	CUL1 KLHL5 MCM3AP RPS11	7.08e-04	245	57	4	19521500
Pubmed	Dimerization quality control ensures neuronal development and survival.	CUL1 KLHL5	7.12e-04	24	57	2	30190310
Pubmed	Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.	CUL1 TTLL5	7.73e-04	25	57	2	29593216
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	RABL6 CENPI PLEKHA5 POLR3A	7.75e-04	251	57	4	29778605
Pubmed	Fgfr2 and Fgfr3 are not required for patterning and maintenance of the midbrain and anterior hindbrain.	NKX2-2 FGF18	8.36e-04	26	57	2	17150206
Pubmed	ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1.	EPRS1 SYNE1 CPT1B	8.60e-04	113	57	3	34474245
Pubmed	C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.	CUL1 RPS11	9.02e-04	27	57	2	29420262
Pubmed	Integrating genetic and network analysis to characterize genes related to mouse weight.	GPD2 NEB	1.04e-03	29	57	2	16934000
Pubmed	Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord.	NKX2-2 MMD2	1.11e-03	30	57	2	23482494
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	RABL6 CUL1 PTPN13 SYNE1 CENPI PLEKHA5	1.13e-03	719	57	6	35337019
Pubmed	Placing the HIRA histone chaperone complex in the chromatin landscape.	CTCF POLR3A	1.19e-03	31	57	2	23602572
Pubmed	MiR-302/367 regulate neural progenitor proliferation, differentiation timing, and survival in neurulation.	NKX2-2 FGF18	1.27e-03	32	57	2	26441343
Pubmed	α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.	PTPN13 PLEKHA5	1.52e-03	35	57	2	37381005
Interaction	TRIM52 interactions	C17orf75 MYO9A TTLL5 RECQL4 PLEKHA5 POLR3A SENP5	8.24e-08	133	56	7	int:TRIM52
Interaction	LURAP1 interactions	MYO9A RECQL4 ZDBF2 HSF2 POLR3A SENP5	2.17e-06	137	56	6	int:LURAP1
Interaction	PIPSL interactions	TTLL5 RECQL4 PLEKHA5 ZDBF2 DNAH14 POLR3A SENP5	6.05e-06	252	56	7	int:PIPSL
Interaction	PHLPP1 interactions	EPRS1 SLK RPS11 PLEKHA5 CHD3 ZDBF2 NEB	3.66e-05	333	56	7	int:PHLPP1
Interaction	FTL interactions	TTLL5 RECQL4 PLEKHA5 ZDBF2 DNAH14 POLR3A SENP5	4.83e-05	348	56	7	int:FTL
Interaction	PNMA2 interactions	EPRS1 MYO9A TTLL5 RECQL4 PLEKHA5 CNGA1	6.78e-05	251	56	6	int:PNMA2
Cytoband	14q24.3	HEATR4 TTLL5 BBOF1	2.06e-04	93	56	3	14q24.3
Cytoband	9q34.3	RABL6 RAPGEF1 GRIN1	3.03e-04	106	56	3	9q34.3
Cytoband	Ensembl 112 genes in cytogenetic band chr14q24	HEATR4 TTLL5 BBOF1	1.90e-03	200	56	3	chr14q24
CoexpressionAtlas	dev gonad_e11.5_F_GonadVasMes_Flk_k-means-cluster#1_top-relative-expression-ranked_1000	KLHL5 DRP2 MYO9A CHD3 PLS3 IP6K2	2.69e-05	224	56	6	gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_k1_1000
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_200	SETD1A VNN1 MMD2 CNGA1 MMD2	6.20e-05	159	56	5	gudmap_developingGonad_e12.5_epididymis_200
ToppCell	LPS-antiTNF-Myeloid-Monocytes,_Macrophages-Neutrophils\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPD2 TECPR2 VNN1 CENPI CHD3	1.93e-06	160	57	5	5d8d97c3da5837ba5fe743d2f8438f5cb7cea64b
Drug	valinomycin; Down 200; 0.1uM; PC3; HT_HG-U133A	RABL6 GPD2 TTLL5 MCM3AP CENPI MAPRE2	8.56e-06	196	56	6	5962_DN
Drug	Meglumine [6284-40-8]; Down 200; 20.4uM; MCF7; HT_HG-U133A	TTLL5 CHD3 CPT1B NEB HSF2 MAPRE2	8.81e-06	197	56	6	5285_DN
Disease	Intellectual Disability	RABL6 SETD1A PITRM1 CTCF SYNE1 CHD3 GRIN1	1.89e-05	447	55	7	C3714756
Disease	ectonucleoside triphosphate diphosphohydrolase 5 measurement	HEATR4 BBOF1	7.00e-04	21	55	2	EFO_0008115
Disease	blood pressure	SYNE1 PREX1	7.69e-04	22	55	2	EFO_0004325

Protein segments in the cluster

Peptide	Gene	Start	Entry
KRFHYQDQEFLKMLN	CYP2B6	186	P20813
TFRQKQLLDMHFKRY	CTCF	531	P49711
IQYFMQKFQLKHLSR	CMTR2	401	Q8IYT2
YKQIAQAAFNLKMRA	BBOF1	381	Q8ND07
ALQRRFAKGVQYNMK	RABL6	31	Q3YEC7
MAFRRQVKNFVKNYS	ENTHD1	1	Q8IYW4
LKYFQDHRNRAMEKS	FAM166C	46	A6NJV1
LLDFQKTKYARFMNH	MMD2	6	Q8IY49
QFAHYRRKQMNLAYV	GPD2	26	P43304
MKENAKHRNQYKFIL	IP6K2	191	Q9UHH9
RNKTAHQMKVQHFYQ	MCM3AP	1316	O60318
DKHNNAKYAVSMARR	PLS3	581	P13797
RENQQDVHFMKRYPK	FGF18	166	O76093
NHAEQTFKKMENYLR	KLHL5	201	Q96PQ7
NNLKRFIRQAEMNHY	C17orf75	331	Q9HAS0
HYVKVMGLQKNFREN	OSGIN2	181	Q9Y236
EIFHLVMYRNYQRKN	CHD3	571	Q12873
YAKMLAKRLVHQNSA	CUL1	466	Q13616
KIFYRRNLQAAKMAQ	GALNT6	441	Q8NCL4
RLHRKSQYLKMAAAN	HEATR4	56	Q86WZ0
FRNYFRHIVNMAIEK	DNAH14	721	Q0VDD8
HNFKLLQASFKRMNV	MAPRE2	116	Q15555
EENMHRYQKAAKLFQ	ERP27	176	Q96DN0
LRMKHLSNYYQNKEN	CCDC168	3176	Q8NDH2
IMHRYRKNLTAAKKN	CENPI	606	Q92674
NNIKFSAYRTAMKLR	DRP2	396	Q13474
DLFQKAAKKHQNMYR	CPT1B	631	Q92523
KKQAFQLRAHMYQAR	OTOF	956	Q9HC10
CSYQHKFQLQMRARQ	PTPN13	861	Q12923
KYFKHNNMASFVRQL	HSF2	51	Q03933
IRKYNRFEKRHKNMS	RPS11	96	P62280
NQHYQVNFKGKLIMR	EPRS1	221	P07814
QLKDQYFMQRHQLLK	SLK	1026	Q9H2G2
FKHFRVQYEMKRKQI	SYNE1	351	Q8NF91
YQYMNGKNKHSVRRL	SAMD8	131	Q96LT4
GNYVRLNMKQKHYVR	RECQL4	351	O94761
QYFKNNQHKLTLSMR	PITRM1	491	Q5JRX3
DKHQFKNEQVMYRFR	PREX1	481	Q8TCU6
IQQRHTQMKRFLKYG	POLR3A	421	O14802
FQNHRYKMKRARAEK	NKX2-2	176	O95096
NLNFRHKMAQYAQRA	DIS3	816	Q9Y2L1
HAQLDIKGQQRMKYY	SETD1A	166	O15047
FQARIDAIKQYMHFR	CNGA1	406	P29973
QKCNFRIFYNKHMLD	SENP5	556	Q96HI0
KLVARYHKQNLFMGE	VNN1	171	O95497
IMKHLRKLNNFNSYL	RAPGEF1	916	Q13905
FRHAQSGYLKRMKNR	STX16	176	O14662
YQKHKESNRKSLRMN	ZDBF2	251	Q9HCK1
CRHLNQMRKYNFEGK	TECPR2	61	O15040
LMFRKQKHEAAINLY	TTC21A	966	Q8NDW8
KGYNSKFNLDMHQRV	ZNF221	541	Q9UK13
MKHQSIRGFVQKQQY	TLR5	801	O60602
NRKYAFKAAHPNMRT	PLEKHA5	231	Q9HAU0
RNQFMHLTNYSVNKK	TTLL5	261	Q6EMB2
VAYHAMLQRKKNQCI	MYO9A	221	B2RTY4
NRHFKYATQLMNEKK	NEB	5391	P20929
RKFANYSIMNLQNRK	GRIN1	346	Q05586