Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	DUF1712	CCZ1B CCZ1	3.76e-05	2	115	2	PF08217
Domain	DUF1712_fun	CCZ1B CCZ1	3.76e-05	2	115	2	IPR013176
Domain	ARM-like	CEP104 HGH1 USP9X APC2 SARM1 PUM2 CUL9 PKP3 MN1	4.46e-05	270	115	9	IPR011989
Domain	-	CEP104 HGH1 USP9X APC2 SARM1 PUM2 CUL9 PKP3	6.98e-05	222	115	8	1.25.10.10
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TPST2 LRRC24 SHC1 CUL9 PLXND1 PLEKHH3 C6orf132 FZD7 WIZ SLC16A5 NUAK1 COQ4 TP53I13 SLC7A5 DISP2 LTBP3 PLK3 ARHGAP21 ABCC10 WNK2	2.82e-09	1105	125	20	35748872
Pubmed	Up-regulated expression of a novel gene in activated human peripheral blood mononuclear cells that is a truncated paralog of the human system L-amino acid transporter 1.	SLC7A5P2 SLC7A5 SLC7A5P1	1.57e-06	7	125	3	12009310
Pubmed	Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase.	USP9X NUAK1 PPP1R12C	9.74e-06	12	125	3	24785407
Pubmed	Functional variants in NFKBIE and RTKN2 involved in activation of the NF-κB pathway are associated with rheumatoid arthritis in Japanese.	RTKN2 NFKBIE	1.28e-05	2	125	2	23028356
Pubmed	Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels.	CACNA1A CACNA1B	1.28e-05	2	125	2	23426690
Pubmed	A mitochondrial iron-responsive pathway regulated by DELE1.	DELE1 LONP1	1.28e-05	2	125	2	37327776
Pubmed	Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers.	CACNA1A CACNA1B	1.28e-05	2	125	2	23376566
Pubmed	p66Shc-generated oxidative signal promotes fat accumulation.	INSR SHC1	1.28e-05	2	125	2	18838380
Pubmed	Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells.	WNT2B FZD7	1.28e-05	2	125	2	28560804
Pubmed	Regional bias of tumor suppressor gene mutations of STARD8 and WNK2 in colon cancers.	STARD8 WNK2	1.28e-05	2	125	2	38091885
Pubmed	Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner.	INSR SHC1	1.28e-05	2	125	2	8702728
Pubmed	CaV 2.1 α1 subunit motifs that control presynaptic CaV 2.1 subtype abundance are distinct from CaV 2.1 preference.	CACNA1A CACNA1B	1.28e-05	2	125	2	38155373
Pubmed	Re-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site.	INSR SHC1	1.28e-05	2	125	2	10340378
Pubmed	Expression analysis of P/Q-type Ca2+ channel alpha 1A subunit mRNA in olfactory mitral cell in N-type Ca2+ channel alpha 1B subunit gene-deficient mice.	CACNA1A CACNA1B	1.28e-05	2	125	2	15050706
Pubmed	PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation.	INSR SHC1	1.28e-05	2	125	2	7953556
Pubmed	LC-MS/MS Based Quantitation of ABC and SLC Transporter Proteins in Plasma Membranes of Cultured Primary Human Retinal Pigment Epithelium Cells and Immortalized ARPE19 Cell Line.	SLC16A1 SLC7A5 ABCC10	2.00e-05	15	125	3	28112518
Pubmed	Phosphatidylserine is a marker for axonal debris engulfment but its exposure can be decoupled from degeneration.	SARM1 BAX	3.84e-05	3	125	2	30389906
Pubmed	Munc13-3 Is Required for the Developmental Localization of Ca2+ Channels to Active Zones and the Nanopositioning of Cav2.1 Near Release Sensors.	CACNA1A CACNA1B	3.84e-05	3	125	2	29466725
Pubmed	PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities.	INSR SHC1	3.84e-05	3	125	2	7499194
Pubmed	PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.	CCZ1B CCZ1	3.84e-05	3	125	2	32160108
Pubmed	Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting.	CACNA1A CACNA1B	3.84e-05	3	125	2	24394417
Pubmed	Functional importance of Shc tyrosine 317 on insulin signaling in Rat1 fibroblasts expressing insulin receptors.	INSR SHC1	3.84e-05	3	125	2	9083103
Pubmed	Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains.	USP9X NUAK1	3.84e-05	3	125	2	18254724
Pubmed	Synergistic antitumor activity of gemcitabine and ABT-737 in vitro and in vivo through disrupting the interaction of USP9X and Mcl-1.	USP9X BAX	3.84e-05	3	125	2	21566062
Pubmed	The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.	CACNA1A CACNA1B	3.84e-05	3	125	2	38996073
Pubmed	Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells.	INSR CPE	3.84e-05	3	125	2	24843127
Pubmed	T-cell death following immune activation is mediated by mitochondria-localized SARM.	SARM1 BAX	3.84e-05	3	125	2	23175186
Pubmed	Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.	CACNA1A CACNA1B	3.84e-05	3	125	2	24523520
Pubmed	Molecular moieties masking Ca2+-dependent facilitation of voltage-gated Cav2.2 Ca2+ channels.	CACNA1A CACNA1B	3.84e-05	3	125	2	29208674
Pubmed	Molecular architecture of CAG repeats in human disease related transcripts.	CACNA1A ATN1	3.84e-05	3	125	2	15223312
Pubmed	Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.	CACNA1A CACNA1B	3.84e-05	3	125	2	26507659
Pubmed	Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2.	INSR SHC1	3.84e-05	3	125	2	10803466
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	ATN1 IRF2BP1 MATR3 TM9SF3 PUM2 MIDEAS GSR LONP1 PKP3	4.30e-05	457	125	9	32344865
Pubmed	Human transcription factor protein interaction networks.	ATN1 IRF2BP1 USP9X MATR3 PSMB6 PUM2 CUL9 TPGS1 R3HDM2 CALML5 MIDEAS KIAA1671 LONP1 WIZ NFKBIE DDX54	5.57e-05	1429	125	16	35140242
Pubmed	Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model.	INSR SLC16A1 SLC7A5	5.75e-05	21	125	3	23137377
Pubmed	Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.	CACNA1A CACNA1B	7.65e-05	4	125	2	32616470
Pubmed	Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons.	CACNA1A CACNA1B	7.65e-05	4	125	2	26283199
Pubmed	Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain.	INSR SHC1	7.65e-05	4	125	2	7537849
Pubmed	A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C.	CACNA1A CACNA1B	7.65e-05	4	125	2	15728831
Pubmed	PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetro-oligomerization through interaction with Bid in human colon cancer.	BAX PLEKHN1	7.65e-05	4	125	2	29531808
Pubmed	Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C.	INSR SHC1	7.65e-05	4	125	2	9446569
Pubmed	The MAP1B-LC1/UBE2L3 complex catalyzes degradation of cell surface CaV2.2 channels.	CACNA1A CACNA1B	7.65e-05	4	125	2	25483588
Pubmed	Cerebellar granule cell signaling is indispensable for normal motor performance.	CACNA1A CACNA1B	7.65e-05	4	125	2	37141091
Pubmed	Interactions of Rabconnectin-3 with Cav2 calcium channels.	CACNA1A CACNA1B	7.65e-05	4	125	2	31253182
Pubmed	Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family.	SHC1 BCL3	7.65e-05	4	125	2	11707390
Pubmed	The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase.	INSR SHC1	7.65e-05	4	125	2	10816433
Pubmed	Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells.	INSR SHC1	7.65e-05	4	125	2	10764799
Pubmed	Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains.	INSR SHC1	7.65e-05	4	125	2	7559478
Pubmed	Potential involvement of FRS2 in insulin signaling.	INSR SHC1	7.65e-05	4	125	2	10650943
Pubmed	Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells.	CCZ1B CCZ1	7.65e-05	4	125	2	20305638
Pubmed	Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via trans-activation of the tyrosine kinase c-kit receptor.	INSR SHC1	7.65e-05	4	125	2	10921922
Pubmed	G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels.	CACNA1A CACNA1B	7.65e-05	4	125	2	15953418
Pubmed	The functional significance of Shc in insulin signaling as a substrate of the insulin receptor.	INSR SHC1	7.65e-05	4	125	2	11075717
Pubmed	Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation.	INSR SHC1	7.65e-05	4	125	2	9121430
Pubmed	Displacement of housekeeping proteasome subunits by MHC-encoded LMPs: a newly discovered mechanism for modulating the multicatalytic proteinase complex.	PSMB6 PSMB9	7.65e-05	4	125	2	8045254
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	ATN1 MATR3 TM9SF3 SARM1 PSMB6 SHC1 BAX PUM2 TPGS1 R3HDM2 KIAA1671 LONP1 RAB3GAP1 WIZ DDX54 SLAIN1	9.52e-05	1496	125	16	32877691
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	GRWD1 USP9X MATR3 CUL9 TPGS1 ITPKC LONP1 DDX54 RAB11FIP5 CEP97	1.09e-04	639	125	10	23443559
Pubmed	Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.	CACNA1A CACNA1B	1.27e-04	5	125	2	8825650
Pubmed	Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin.	INSR SHC1	1.27e-04	5	125	2	9593725
Pubmed	M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole.	MPHOSPH9 CEP97	1.27e-04	5	125	2	30375385
Pubmed	Selective gene activation by spatial segregation of insulin receptor B signaling.	INSR SHC1	1.27e-04	5	125	2	17264162
Pubmed	Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit.	CACNA1A CACNA1B	1.27e-04	5	125	2	16787652
Pubmed	Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.	CACNA1A CACNA1B	1.27e-04	5	125	2	15451373
Pubmed	Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc.	INSR SHC1	1.27e-04	5	125	2	12237775
Pubmed	A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth.	INSR SHC1	1.27e-04	5	125	2	9741627
Pubmed	Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells.	INSR SHC1	1.27e-04	5	125	2	10896916
Pubmed	Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.	CACNA1A CACNA1B	1.27e-04	5	125	2	11296258
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	GRWD1 USP9X MATR3 RPP38 PUM2 CALML5 NUAK1 HSBP1L1 NFKBIE RAB11FIP5 PATJ ARHGAP21	1.28e-04	922	125	12	27609421
Pubmed	Gene expression in the developing mouse retina by EST sequencing and microarray analysis.	ATP23 TM9SF3 CMPK2 CCDC13 WIZ	1.67e-04	142	125	5	11812828
Pubmed	Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc.	INSR SHC1	1.90e-04	6	125	2	9710204
Pubmed	An action potential initiation mechanism in distal axons for the control of dopamine release.	CACNA1A CACNA1B	1.90e-04	6	125	2	35324301
Pubmed	Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.	CACNA1A CACNA1B	1.90e-04	6	125	2	12827191
Pubmed	Elevated insulin signaling disrupts the growth and differentiation pattern of the mouse lens.	INSR SHC1	1.90e-04	6	125	2	17417601
Pubmed	Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.	CACNA1A CACNA1B	1.90e-04	6	125	2	9238069
Pubmed	Sequence analysis of β-subunit genes of the 20S proteasome in patients with relapsed multiple myeloma treated with bortezomib or dexamethasone.	PSMB6 PSMB9	1.90e-04	6	125	2	23018640
Pubmed	Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.	INSR SHC1	1.90e-04	6	125	2	10635327
Pubmed	beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain.	CACNA1A CACNA1B	1.90e-04	6	125	2	10328888
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNA1A LRRC24 USP9X MATR3 APC2 KANK2 CCDC13 DLGAP3 WIZ FRMPD3 ARHGAP21 WNK2	1.91e-04	963	125	12	28671696
Pubmed	NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells.	USP9X MATR3 APC2	2.08e-04	32	125	3	17267499
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	ATN1 PUM2 R3HDM2 MIDEAS MPHOSPH9	2.30e-04	152	125	5	38360978
Pubmed	Genetic testing in spinocerebellar ataxia in Taiwan: expansions of trinucleotide repeats in SCA8 and SCA17 are associated with typical Parkinson's disease.	CACNA1A ATN1	2.66e-04	7	125	2	14756671
Pubmed	Rebuilding essential active zone functions within a synapse.	CACNA1A CACNA1B	2.66e-04	7	125	2	35176221
Pubmed	Human Bop is a novel BH3-only member of the Bcl-2 protein family.	RTL10 BAX	2.66e-04	7	125	2	23055042
Pubmed	Mechanisms of MCL-1 Protein Stability Induced by MCL-1 Antagonists in B-Cell Malignancies.	USP9X BAX	2.66e-04	7	125	2	36346691
Pubmed	SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor.	INSR SHC1	2.66e-04	7	125	2	10482988
Pubmed	Genetic mouse models of extended lifespan.	INSR SHC1	2.66e-04	7	125	2	14698816
Pubmed	The retardation of aging by caloric restriction: its significance in the transgenic era.	INSR SHC1	2.66e-04	7	125	2	14698815
Pubmed	Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments.	CACNA1A ROBO3	2.66e-04	7	125	2	27805050
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	CALML5 MIDEAS KANK2 SLC4A1AP NFKBIE RAB11FIP5 CEP97 ARHGAP21	3.19e-04	472	125	8	38943005
Pubmed	Comparative analysis of the signaling capabilities of the insulin receptor-related receptor.	INSR SHC1	3.54e-04	8	125	2	15629149
Pubmed	Sema3E/PlexinD1 regulates the migration of hem-derived Cajal-Retzius cells in developing cerebral cortex.	WNT2B PLXND1	3.54e-04	8	125	2	24969029
Pubmed	Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif.	USP9X GSR PATJ	4.06e-04	40	125	3	30865227
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	CACNA1B PSMB6 PSMB9 CUL9 MIDEAS KANK2 GSR DDX54	4.44e-04	496	125	8	31343991
Pubmed	Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease.	CACNA1A CPE	4.54e-04	9	125	2	15917267
Pubmed	Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.	INSR SHC1	4.54e-04	9	125	2	25187647
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1A CACNA1B	4.54e-04	9	125	2	16382099
Pubmed	Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.	INSR SHC1	4.54e-04	9	125	2	11094073
Pubmed	The mouse genes encoding the third pair of beta-type proteasome subunits regulated reciprocally by IFN-gamma: structural comparison, chromosomal localization, and analysis of the promoter.	PSMB6 PSMB9	4.54e-04	9	125	2	9300697
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	IRF2BP1 ORC6 USP9X TMEM165 TM9SF3 CALML5 RAB3GAP1 OTOP1 RAB11FIP5	5.16e-04	638	125	9	31182584
Pubmed	Pronounced up-regulation of the PA28alpha/beta proteasome regulator but little increase in the steady-state content of immunoproteasome during dendritic cell maturation.	PSMB6 PSMB9	5.66e-04	10	125	2	11745344
Interaction	TOP3B interactions	TPST2 GRWD1 LRRC24 SHC1 CUL9 R3HDM2 PLXND1 KANK2 PLEKHH3 C6orf132 FBXL6 FZD7 LONP1 WIZ SLC16A5 NUAK1 COQ4 TP53I13 SLC7A5 DISP2 LTBP3 PLK3 ARHGAP21 ABCC10 WNK2	2.05e-06	1470	122	25	int:TOP3B
Interaction	CACNB1 interactions	CACNA1A CACNA1B ATN1 CCZ1	1.47e-05	25	122	4	int:CACNB1
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	CACNA1A APC2 INSR TPGS1 KANK2 FCHO1 FGF22 LONP1 WIZ GRIN3B	6.94e-05	797	125	10	chr19p13
Cytoband	6p21.1	CUL9 C6orf132 NFKBIE ABCC10	7.06e-05	80	125	4	6p21.1
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	PCDHA9 JADE2 MATR3 NRG2 DELE1 PROB1	1.75e-04	298	125	6	chr5q31
ToppCell	normal_Lung-T/NK_cells-CD8+/CD4+_Mixed_Th\|T/NK_cells / Location, Cell class and cell subclass	CACNA1A ATP23 GRWD1 DELE1 MIDEAS ARHGAP21	9.21e-06	172	125	6	0657c736f3c52d25cf7f652eac005ddcde9232ef
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ATP23 IRF2BP1 PLEKHN1 FCHO1 RAB3GAP1 CEP97	1.02e-05	175	125	6	f3a68aeb79c4935006e17a5ff3445a8ec0e33f5f
ToppCell	E18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	JADE2 RPP38 CMPK2 CPE RAB11FIP5 ROBO3	1.08e-05	177	125	6	8dfadd9852e0c256363471a7cfe6af120c8c51e0
ToppCell	E18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	JADE2 RPP38 CMPK2 CPE RAB11FIP5 ROBO3	1.08e-05	177	125	6	767b2af5f224d100b22bed32f86cec1cd17e8711
ToppCell	E18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	JADE2 RPP38 CMPK2 CPE RAB11FIP5 ROBO3	1.08e-05	177	125	6	5ef2527e9b41e62f1724cdabaad9d8979266bb7d
ToppCell	E18.5-Endothelial-Endothelial_lymphatic\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	JADE2 RPP38 CMPK2 CPE RAB11FIP5 ROBO3	1.08e-05	177	125	6	ae1d2fdd4f67f50c906b27ea084de058c6908aa2
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ANO2 WNT2B CPE NUAK1 PPP1R16B ELN	1.39e-05	185	125	6	a7ae76058b2082020cadec49d63b9f4e24d21734
ToppCell	Endothelial-Endothelial-E\|Endothelial / shred on cell class and cell subclass (v4)	CACNA1A CPE PLXND1 NUAK1 LTBP3 ELN	1.53e-05	188	125	6	2777eb7689b271c199021fe7d9db88ccebff14de
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GARIN5A CPE PLEKHN1 C6orf132 LTBP3 ELN	1.62e-05	190	125	6	3cf464664d6aa22b212e60b70885953887e92483
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	WNT2B PLEKHN1 FCHO1 LINC00479 SLAIN1 PATJ	1.67e-05	191	125	6	4c4eb61e6179d2f8fc524d2f813db9cba84f67a2
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TPST2 ANO2 PLXND1 KIAA1671 NUAK1 PPP1R16B	1.82e-05	194	125	6	fc2e0081005c0c496e41197a2d06e4a37708221f
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL7A1 NRG2 CPE TCL1B PROB1 WNK2	1.93e-05	196	125	6	a58bdf9de05d13d84211e09a933679d485bf8ab4
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STARD8 HYAL1 INSR PLXND1 NUAK1 PPP1R16B	1.93e-05	196	125	6	e224338490691d92c1f70b57112fabdcc92b06a9
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STARD8 HYAL1 INSR PLXND1 NUAK1 PPP1R16B	1.99e-05	197	125	6	c10dd1aaec01fb662eac83dfde90e3e426665d65
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STARD8 HYAL1 INSR PLXND1 NUAK1 PPP1R16B	1.99e-05	197	125	6	2844dbcd0a673ed81c99920aa45858651a00736d
ToppCell	LPS_only-Myeloid-Dendritic_cells-pDC\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO7B FCHO1 TP53I13 SLC7A5 MN1	3.97e-05	135	125	5	0afe232aa1a1e6c37a5b3183b67d7fa07e0ea791
ToppCell	moderate-Epithelial-unknown_epithelial\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	COL7A1 PLEKHN1 FZD7 ITPKC PPP1R12C	4.41e-05	138	125	5	afefa8233c67aa744e939156bc538449bf6bd05b
Drug	Meglumine [6284-40-8]; Up 200; 20.4uM; MCF7; HT_HG-U133A	TPST2 LRP12 IRF2BP1 RTL10 BAX CUL9 PLXND1 FCHO1 WIZ	1.27e-06	197	123	9	5285_UP
Drug	Bicuculline (+) [485-49-4]; Up 200; 10.8uM; MCF7; HT_HG-U133A	STARD8 IRF2BP1 WNT2B NRG2 CUL9 CALML5 DENND2B RAB11FIP5	1.11e-05	195	123	8	2796_UP
Drug	Apomorphine hydrochloride hemihydrate [41372-20-7]; Up 200; 6.4uM; MCF7; HT_HG-U133A	TPST2 LRP12 CUL9 FCHO1 FBXL6 WIZ SLC16A1 PATJ	1.11e-05	195	123	8	5283_UP
Drug	Phenindione [83-12-5]; Up 200; 18uM; HL60; HG-U133A	CACNA1A LRP12 JMJD4 FBXL6 FZD7 RAB3GAP1 WIZ PKP3	1.20e-05	197	123	8	1718_UP
Disease	familial hemiplegic migraine 1 (implicated_via_orthology)	CACNA1A CACNA1B	4.99e-05	3	121	2	DOID:0111181 (implicated_via_orthology)
Disease	migraine (implicated_via_orthology)	CACNA1A CACNA1B	9.95e-05	4	121	2	DOID:6364 (implicated_via_orthology)
Disease	teratoma (is_marker_for)	WNT2B BAX	1.65e-04	5	121	2	DOID:3307 (is_marker_for)
Disease	hereditary ataxia (implicated_via_orthology)	CACNA1A CACNA1B	3.46e-04	7	121	2	DOID:0050951 (implicated_via_orthology)
Disease	Familial hyperinsulinism	INSR SLC16A1	4.59e-04	8	121	2	cv:C3888018
Disease	renal cell carcinoma	MYO7B INSR ZNF620	6.87e-04	42	121	3	EFO_0000681
Disease	hepatocellular carcinoma (biomarker_via_orthology)	INSR SHC1 BAX SLC7A5	1.04e-03	108	121	4	DOID:684 (biomarker_via_orthology)
Disease	Amelogenesis Imperfecta	TMEM165 LTBP3	1.07e-03	12	121	2	C0002452
Disease	Hermansky-Pudlak syndrome (implicated_via_orthology)	CCZ1B CCZ1	1.47e-03	14	121	2	DOID:3753 (implicated_via_orthology)
Disease	Alzheimer's disease (biomarker_via_orthology)	INSR BAX GSR	1.76e-03	58	121	3	DOID:10652 (biomarker_via_orthology)
Disease	Cardiovascular Abnormalities	ATN1 APC2	1.93e-03	16	121	2	C0243050
Disease	Huntington's disease (biomarker_via_orthology)	BAX GSR	1.93e-03	16	121	2	DOID:12858 (biomarker_via_orthology)
Disease	Global developmental delay	CACNA1B ATN1 APC2 MN1	2.23e-03	133	121	4	C0557874
Disease	neuroticism measurement, cognitive function measurement	TPST2 PCDHA9 JADE2 R3HDM2 FPGT FCHO1 RAB11FIP5 MPHOSPH9	2.36e-03	566	121	8	EFO_0007660, EFO_0008354
Disease	Feeding difficulties	ATN1 MN1	2.44e-03	18	121	2	C0232466
Disease	photoreceptor cell layer thickness measurement	CEP104 SLC16A1 RP1L1 MN1	3.28e-03	148	121	4	EFO_0803370

Protein segments in the cluster

Peptide	Gene	Start	Entry
GQGRAASMPRLPAEN	CACNA1A	2086	O00555
LRASPAAMDGGALEP	LINC00479	6	Q96M42
MALLPRALSAGAGPS	GSR	1	P00390
ERLALAAGPALRPDM	ATN1	1001	P54259
EGLALDMGTAPRSLP	RTL10	221	Q7L3V2
LLVAADGPMPFLGRA	FBXL6	126	Q8N531
MDEPALRSPGGGDRS	ANO2	961	Q9NQ90
LPGAGNEVLELRRPM	DENND2B	851	P78524
DELRRAMAGLGQPLP	CALML5	101	Q9NZT1
PGLESQGRAASMPRL	CACNA1B	1991	Q00975
LAAELGMAPPGLRRG	DISP2	931	A7MBM2
GRISRPGMALGAPEV	R3HDM2	371	Q9Y2K5
GGPKEMANLRPEGRL	RAB3GAP1	606	Q15042
NAPALLTPRMRGTDG	PCDHA9	561	Q9Y5H5
LARLLGPSEVMAGPA	TP53I13	16	Q8NBR0
MALVRGAEPAAGPSR	RAB11FIP5	1	Q9BXF6
GALPAAARMGLEAPR	ITPKC	16	Q96DU7
PGARTGLGAPVRLMA	PUM2	451	Q8TB72
MAATLLAARGAGPAP	PSMB6	1	P28072
MAGAPDERRRGPAAG	ATP23	1	Q9Y6H3
LEALAGGDLMPAPAD	FCHO1	536	O14526
PMGRDALGSLSPALE	FHDC1	726	Q9C0D6
KRRPLANGLAMAGSP	SLC16A1	141	P53985
LMEAGRLIRAGPPSE	ABCC10	796	Q5T3U5
GPLRMRDAGLLVEQP	NFATC2	126	Q13469
GDGLRPDMALRQPSR	KLHL33	216	A6NCF5
RRDMAGASGGVAAPL	LRP12	661	Q9Y561
ERMGRGPGPLQERSL	MATR3	251	P43243
PAAKDLDNRMPGLVG	KIAA1671	101	Q9BY89
SGPTAGDMAGLERPR	KIAA1671	306	Q9BY89
GRGPPLREGEELVMD	GRWD1	36	Q9BQ67
GPRPARAAGMSEARK	NFKBIE	131	O00221
MAADKGPAAGPRSRA	DDX54	1	Q8TDD1
VTRRLPGARPDAGMG	JADE2	716	Q9NQC1
MAPRAAGGAPLSARA	PLXND1	1	Q9Y4D7
MAAARPSLGRVLPGS	ISOC2	1	Q96AB3
MAGAGPKRRALAAPV	SLC7A5P1	1	Q8MH63
RAAAAGGMRRDPAPG	NRG2	86	O14511
IEAALSRMPSPGGRI	MPHOSPH9	976	Q99550
MAGAGPKRRALAAPA	SLC7A5	1	Q01650
EPRPEAGSMAFRALG	LRRC24	386	Q50LG9
RPMLAAAGGRVPTAA	LONP1	21	P36776
LPSDGDIAMRRDRGP	GARIN5A	56	Q6IPT2
GQPMFLALDRRGGPR	FGF22	136	Q9HCT0
MAGAGPKRRALAAPV	SLC7A5P2	1	Q9GIP4
MATGGRRGAAAAPLL	INSR	1	P06213
MLRAGAPTGDLPRAG	PSMB9	1	P28065
MAAPGLRLGAGRLFE	GTPBP8	1	Q8N3Z3
PRGLQGAGPRRDTMA	NPTXR	166	O95502
PRGELDMPVENGLRA	PPP1R16B	416	Q96T49
MLEGLGSPASPRAAA	OTOP1	1	Q7RTM1
MRRVNSAGRAPPGGL	C6orf132	1101	Q5T0Z8
RMAGPQGLDLAPILR	DERPC	266	P0CG12
MRDPGAAAPLSSLGL	FZD7	1	O75084
RAGAPGAPGAKDARM	APC2	331	O95996
LLGRRGVCAGAMAPP	CMPK2	16	Q5EBM0
SDARRGGMLGEPEPL	CEP104	406	O60308
MGATGRLELTLAAPP	DNAH3	1	Q8TD57
MAVARVDAALPPGEG	CEP97	1	Q8IW35
NPPSRGERRLEASMG	FRMPD3	1011	Q5JV73
GRMGGEAPELALDPV	BAX	36	Q07812
MRAGPEPQALAGQKR	JMJD4	1	Q9H9V9
DAGAKPPRAQMGDRA	CCDC13	186	Q8IYE1
LAGRDSPIRAEMPGN	CCZ1	261	P86791
MGRPLEGQPLRALDL	LINC02875	1	Q86X59
DGPAMGARTLELAPV	DLGAP3	586	O95886
EAQEPGAPAAGMRRR	CPE	26	P16870
LAGRDSPIRAEMPGN	CCZ1B	261	P86790
PAAEMPLRARSDGAG	COQ4	21	Q9Y3A0
AMAAARGGPVPAARE	EID2	46	Q8N6I1
RGGPVPAAREGRMAA	EID2	51	Q8N6I1
LAPEMRGAGAAGLLA	LTBP3	11	Q9NS15
LAPNGREREAPAMGS	MIDEAS	416	Q6PJG2
GTGLRALAMPGRPES	KANK2	361	Q63ZY3
ASEMARALRGPGPRS	CUL9	661	Q8IWT3
GMAGADPEQLRRLAP	COL7A1	1191	Q02388
LDMAQGFRGPLLPNR	HYAL1	16	Q12794
MEGARLGLPGRAESL	nan	81	Q6ZN92
SGPELTGMPRVRLAA	C1orf127	516	Q8N9H9
AGAMDEGPVDLRTRP	BCL3	6	P20749
MAGLTAAAPRPGVLL	ELN	1	P15502
GGAMAAARDPPEVSL	FPGT	11	O14772
RLRALFSMGAAAPGP	DELE1	426	Q14154
VAEGARRALLGSMPG	IRF2BP1	146	Q8IU81
ADPGLPARLMGRALD	HGH1	101	Q9BTY7
DLLPRRMGGSGLPAD	MN1	641	Q10571
GDAGLRARLAPMAAP	GRIN3B	211	O60391
RARLAPMAAPVGGEA	GRIN3B	216	O60391
MEGPSLRGPALRLAG	RTKN2	1	Q8IZC4
DLGSSLNMPPLRDGA	USP9X	1026	Q93008
ALEGARRPGPLMQGV	PLEKHH3	276	Q7Z736
SARMSAGLPGPEAAR	PLEKHN1	31	Q494U1
EARLMLRAADPGPGA	PPP1R12C	66	Q9BZL4
MAAAPQAPGRGSLRK	RPP38	1	P78345
EAMDGRAELPAFPRA	NKX1-1	36	Q15270
MDVRGPEAPGGRALR	HSBP1L1	1	C9JCN9
RAPSQLPRGGLTEMA	RNF227	81	A6NIN4
MGRSALPRPSLAING	SLAIN1	516	Q8ND83
PRLIPGAGATEMALA	CCT8L1P	406	A6NM43
PRLIPGAGATEMALA	CCT8L2	406	Q96SF2
MEGAAAPVAGDRPDL	NUAK1	1	O60285
IGRLAPRLGLAEPDM	ORC6	6	Q9Y5N6
MEGSLAGSLAAPDRP	WIZ	1	O95785
VLGPGEAASGRPRMA	PROB1	606	E7EW31
AGDPGLGPEELRAAM	STRC	1496	Q7RTU9
SLIGRPGPRDLSDNM	STARD8	746	Q92502
EMPPSALQRLEGRGR	PKP3	541	Q9Y446
SALRGPELEMLAGLP	PLK3	31	Q9H4B4
AGLRSPRGAMRPEQE	TPST2	36	O60704
GPPGSREMGLLTFRD	ZNF735	6	P0CB33
FLRPLAGLMAGRPAF	SLC16A5	286	O15375
GRAGRMVLEPPREAL	RP1L1	1581	Q8IWN7
FAMSGPRPGAERLAV	SARM1	16	Q6SZW1
PEGPAAADGRMRIGD	PATJ	1271	Q8NI35
SLNGSRVGPEDAMPR	ROBO3	51	Q96MS0
SQPMLGIREARPAGL	ROBO3	1191	Q96MS0
MGPQRRLSPAGAALL	SPPL2A	1	Q8TCT8
EPMGREALRGICPGD	ZNF620	76	Q6ZNG0
GPPGSREMGLLTFRD	ZNF716	6	A6NP11
MAAAAPGNGRASAPR	TMEM165	1	Q9HC07
MASEASVRLGVPPGR	TCL1B	1	O95988
GPPGSREMGLLTFRD	ZNF479	6	Q96JC4
MRPLPGALGVAAAAA	TM9SF3	1	Q9HD45
MGAAAAEAPLRLPAA	TMEFF1	1	Q8IYR6
AGPAGMAEPRAKAAR	WNK2	21	Q9Y3S1
LRPRAPADDMFGVGN	ARHGAP21	1771	Q5T5U3
LDRAVGGRRPSAPMT	TPGS1	256	Q6ZTW0
MRLREGAAPGAARPT	SHC1	366	P29353
MLRPGGAEEAAQLPL	WNT2B	1	Q93097
LEPDGLGADRPMSNL	MYO7B	1076	Q6PIF6
MLAPLRNAPGREGAT	SLC4A1AP	1	Q9BWU0