Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionolfactory receptor activity

OR10A3 OR2W3 OR51T1 OR5T1 OR4S1 OR13D1 OR13C5 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR1P1 OR10A6 OR2D2 OR10H4 OR5AK3P OR2J1 OR6K3 OR4C12 OR10J4 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 OR4F6 OR2W6P

1.96e-354316231GO:0004984
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR10A3 OR2W3 OR51T1 OR5T1 OR4S1 OR13D1 NPY5R P2RY1 OR13C5 MRGPRX1 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR1P1 OR10A6 OR2D2 MRGPRX3 OR10H4 OR5AK3P MRGPRX4 OR2J1 OR6K3 OR4C12 OR10J4 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 CXCR1 OR4F6 OR2W6P

1.99e-348846237GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR10A3 OR2W3 OR51T1 OR5T1 OR4S1 OR13D1 NPY5R P2RY1 IL1RAPL2 OR13C5 MRGPRX1 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR1P1 OR10A6 OR2D2 MRGPRX3 OR10H4 TRPV4 OR5AK3P MRGPRX4 OR2J1 OR6K3 OR4C12 OR10J4 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 CXCR1 OR4F6 OR2W6P

1.98e-3013536239GO:0004888
GeneOntologyMolecularFunctionodorant binding

OR5T1 OR9Q2 OR10K1 OR5AK3P OR6K3 OR10J4 OR5M3 OR5M11 OR6K6

1.95e-10127629GO:0005549
GeneOntologyMolecularFunctionneuropeptide binding

NPY5R MRGPRX1 MRGPRX3 MRGPRX4

5.15e-0637624GO:0042923
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1C CACNA1D CACNA1F

1.01e-0514623GO:0008331
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1C CACNA1D CACNA1F TPCN2

1.25e-0546624GO:0005245
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA1C CACNA1D CACNA1F SLC9C1 TPCN2 SLC5A7 TRPV4 ATP1A1 ATP1A4

1.27e-05465629GO:0046873
GeneOntologyMolecularFunctionneuropeptide receptor activity

NPY5R MRGPRX1 MRGPRX3 MRGPRX4

2.20e-0553624GO:0008188
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1C CACNA1D CACNA1F TPCN2 TRPV4

5.02e-05129625GO:0005262
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in cardiac muscle cell action potential

CACNA1C CACNA1D

9.43e-055622GO:0086007
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1C CACNA1D CACNA1F TPCN2 TRPV4

1.06e-04151625GO:0015085
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

CACNA1C CACNA1D CACNA1F SLC9C1 TPCN2 SLC5A7 TRPV4 ATP1A1 ATP1A4

1.29e-04627629GO:0022890
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

CACNA1C CACNA1D CACNA1F SLC9C1 TPCN2 SLC5A7 TRPV4 ATP1A1 TMC5 ATP1A4

1.52e-047936210GO:0015075
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC9C1 TPCN2 SLC5A7 ATP1A1 ATP1A4

1.89e-04171625GO:0015081
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1C CACNA1D CACNA1F SLC9C1 TPCN2 SLC5A7 TRPV4 ATP1A1 ATP1A4

1.98e-04664629GO:0008324
GeneOntologyMolecularFunctionP-type sodium transporter activity

ATP1A1 ATP1A4

4.20e-0410622GO:0008554
GeneOntologyMolecularFunctionP-type sodium:potassium-exchanging transporter activity

ATP1A1 ATP1A4

4.20e-0410622GO:0005391
GeneOntologyMolecularFunctionP-type potassium transmembrane transporter activity

ATP1A1 ATP1A4

5.12e-0411622GO:0008556
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

CACNA1C CACNA1D CACNA1F SLC9C1 TPCN2 SLC5A7 TRPV4 ATP1A1 ATP1A4

5.22e-04758629GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CACNA1C CACNA1D CACNA1F SLC9C1 TPCN2 TRPV4 TMC5

5.35e-04459627GO:0005216
GeneOntologyMolecularFunctiongated channel activity

CACNA1C CACNA1D CACNA1F TPCN2 TRPV4 TMC5

5.85e-04334626GO:0022836
GeneOntologyMolecularFunctionG protein-coupled peptide receptor activity

NPY5R MRGPRX1 MRGPRX3 MRGPRX4

7.78e-04133624GO:0008528
GeneOntologyMolecularFunctionpeptide receptor activity

NPY5R MRGPRX1 MRGPRX3 MRGPRX4

9.42e-04140624GO:0001653
GeneOntologyMolecularFunctionchannel activity

CACNA1C CACNA1D CACNA1F SLC9C1 TPCN2 TRPV4 TMC5

1.18e-03525627GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CACNA1C CACNA1D CACNA1F SLC9C1 TPCN2 TRPV4 TMC5

1.19e-03526627GO:0022803
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

CACNA1C CACNA1D CACNA1F TPCN2

1.28e-03152624GO:0022843
GeneOntologyMolecularFunctionmechanosensitive monoatomic ion channel activity

TRPV4 TMC5

1.41e-0318622GO:0008381
GeneOntologyMolecularFunctionankyrin binding

CACNA1D ATP1A1

2.30e-0323622GO:0030506
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CACNA1C CACNA1D CACNA1F TPCN2

2.47e-03182624GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CACNA1C CACNA1D CACNA1F TPCN2

2.57e-03184624GO:0022832
GeneOntologyMolecularFunctionscavenger receptor activity

SCARA3 MEGF10

3.17e-0327622GO:0005044
GeneOntologyMolecularFunctiontransmembrane transporter activity

CACNA1C CACNA1D CACNA1F SLC9C1 TPCN2 SLC5A7 TRPV4 ATP1A1 TMC5 ATP1A4

3.24e-0311806210GO:0022857
GeneOntologyMolecularFunctionalpha-actinin binding

CACNA1C CACNA1D

4.16e-0331622GO:0051393
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1C CACNA1D CACNA1F TPCN2 TRPV4

4.22e-03343625GO:0005261
GeneOntologyMolecularFunctionP-type transmembrane transporter activity

ATP1A1 ATP1A4

5.58e-0336622GO:0140358
GeneOntologyMolecularFunctionP-type ion transporter activity

ATP1A1 ATP1A4

5.58e-0336622GO:0015662
GeneOntologyMolecularFunctiontransporter activity

CACNA1C CACNA1D CACNA1F SLC9C1 TPCN2 SLC5A7 TRPV4 ATP1A1 TMC5 ATP1A4

6.03e-0312896210GO:0005215
GeneOntologyMolecularFunctionprotein phosphatase 2A binding

CACNA1C HMGCR

7.54e-0342622GO:0051721
GeneOntologyMolecularFunctionactinin binding

CACNA1C CACNA1D

7.89e-0343622GO:0042805
GeneOntologyMolecularFunctionADP binding

P2RY1 ATP1A1

9.76e-0348622GO:0043531
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC9C1 SLC5A7 ATP1A1 ATP1A4

1.42e-02301624GO:0022853
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR10A3 OR2W3 OR51T1 OR5T1 OR4S1 OR13D1 OR13C5 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR1P1 OR10A6 OR2D2 OR10H4 OR5AK3P OR2J1 OR6K3 OR4C12 OR10J4 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 OR4F6 OR2W6P

7.86e-364326231GO:0050911
GeneOntologyBiologicalProcesssensory perception of smell

OR10A3 OR2W3 OR51T1 OR5T1 OR4S1 OR13D1 OR13C5 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR1P1 OR10A6 OR2D2 OR10H4 OR5AK3P OR2J1 OR6K3 OR4C12 OR10J4 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 OR4F6 OR2W6P

7.94e-354656231GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR10A3 OR2W3 OR51T1 OR5T1 OR4S1 OR13D1 OR13C5 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR1P1 OR10A6 OR2D2 OR10H4 OR5AK3P OR2J1 OR6K3 OR4C12 OR10J4 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 OR4F6 OR2W6P

2.97e-344856231GO:0050907
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR10A3 OR2W3 OR51T1 CACNA1F OR5T1 OR4S1 OR13D1 OR13C5 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR1P1 OR10A6 OR2D2 OR10H4 OR5AK3P OR2J1 OR6K3 OR4C12 OR10J4 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 OR4F6 OR2W6P

2.30e-335826232GO:0050906
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR10A3 OR2W3 OR51T1 OR5T1 OR4S1 OR13D1 OR13C5 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR1P1 OR10A6 OR2D2 OR10H4 OR5AK3P OR2J1 OR6K3 OR4C12 OR10J4 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 OR4F6 OR2W6P

3.32e-335246231GO:0009593
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR10A3 OR2W3 OR51T1 OR5T1 OR4S1 OR13D1 OR13C5 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR1P1 OR10A6 OR2D2 OR10H4 OR5AK3P OR2J1 OR6K3 OR4C12 OR10J4 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 OR4F6 OR2W6P

1.26e-325476231GO:0007606
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR10A3 OR2W3 OR51T1 CACNA1D OR5T1 OR4S1 OR13D1 NPY5R P2RY1 OR13C5 MRGPRX1 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR1P1 OR10A6 OR2D2 MRGPRX3 OR10H4 OR5AK3P MRGPRX4 OR2J1 OR6K3 OR4C12 OR10J4 VPS54 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 CXCR1 OR4F6 OR2W6P

1.87e-3013956239GO:0007186
GeneOntologyBiologicalProcessdetection of stimulus

OR10A3 OR2W3 OR51T1 CACNA1F OR5T1 OR4S1 OR13D1 OR13C5 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR1P1 OR10A6 OR2D2 OR10H4 OR5AK3P OR2J1 OR6K3 OR4C12 OR10J4 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 OR4F6 OR2W6P

2.20e-307226232GO:0051606
GeneOntologyBiologicalProcesssensory perception

OR10A3 OR2W3 OR51T1 CACNA1D CACNA1F OR5T1 OR4S1 OR13D1 OR13C5 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR1P1 OR10A6 OR2D2 OR10H4 OR5AK3P OR2J1 OR6K3 OR4C12 OR10J4 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 OR4F6 OR2W6P

2.49e-2610726233GO:0007600
GeneOntologyBiologicalProcessinorganic ion import across plasma membrane

CACNA1C CACNA1D CACNA1F SLC9C1 TRPV4 ATP1A1 ATP1A4

2.26e-07142627GO:0099587
GeneOntologyBiologicalProcessinorganic cation import across plasma membrane

CACNA1C CACNA1D CACNA1F SLC9C1 TRPV4 ATP1A1 ATP1A4

2.26e-07142627GO:0098659
GeneOntologyBiologicalProcessresponse to chloroquine

MRGPRX1 MRGPRX3 MRGPRX4

2.58e-075623GO:1902349
GeneOntologyBiologicalProcessimport across plasma membrane

CACNA1C CACNA1D CACNA1F SLC9C1 TRPV4 ATP1A1 ATP1A4

5.71e-06230627GO:0098739
GeneOntologyBiologicalProcesscalcium ion import across plasma membrane

CACNA1C CACNA1D CACNA1F TRPV4

1.30e-0548624GO:0098703
GeneOntologyBiologicalProcesscalcium ion import into cytosol

CACNA1C CACNA1D CACNA1F TRPV4

1.30e-0548624GO:1902656
GeneOntologyBiologicalProcessintracellular chemical homeostasis

CACNA1C CACNA1D CACNA1F SLC9C1 TPCN2 P2RY1 TRPV4 HMGCR VPS54 ATP1A1 ATP1A4

4.80e-058666211GO:0055082
GeneOntologyBiologicalProcessintracellular monoatomic cation homeostasis

CACNA1C CACNA1F SLC9C1 TPCN2 P2RY1 TRPV4 VPS54 ATP1A1 ATP1A4

8.28e-05611629GO:0030003
GeneOntologyBiologicalProcesspositive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

CACNA1C CACNA1D

8.84e-055622GO:1904879
GeneOntologyBiologicalProcessintracellular monoatomic ion homeostasis

CACNA1C CACNA1F SLC9C1 TPCN2 P2RY1 TRPV4 VPS54 ATP1A1 ATP1A4

9.48e-05622629GO:0006873
GeneOntologyBiologicalProcesschemosensory behavior

MRGPRX1 MRGPRX3 MRGPRX4

1.09e-0431623GO:0007635
GeneOntologyBiologicalProcessexport from cell

CACNA1C CACNA1D TPCN2 NPY5R P2RY1 MRGPRX1 MRGPRX3 TRPV4 MRGPRX4 HMGCR ATP1A1 ATP1A4

1.41e-0411536212GO:0140352
GeneOntologyBiologicalProcesscellular homeostasis

CACNA1C CACNA1D CACNA1F SLC9C1 TPCN2 P2RY1 TRPV4 HMGCR VPS54 ATP1A1 ATP1A4

1.46e-049816211GO:0019725
GeneOntologyBiologicalProcesscalcium ion import

CACNA1C CACNA1D CACNA1F TRPV4

2.16e-0498624GO:0070509
GeneOntologyBiologicalProcessmonoatomic cation homeostasis

CACNA1C CACNA1F SLC9C1 TPCN2 P2RY1 TRPV4 VPS54 ATP1A1 ATP1A4

2.43e-04705629GO:0055080
GeneOntologyBiologicalProcessosmosensory signaling pathway

TRPV4 ATP1A1

2.46e-048622GO:0007231
GeneOntologyBiologicalProcessmonoatomic ion homeostasis

CACNA1C CACNA1F SLC9C1 TPCN2 P2RY1 TRPV4 VPS54 ATP1A1 ATP1A4

2.75e-04717629GO:0050801
GeneOntologyBiologicalProcessvesicle-mediated cholesterol transport

TPCN2 VPS54

3.16e-049622GO:0090119
GeneOntologyBiologicalProcessimport into cell

CACNA1C CACNA1D CACNA1F SLC9C1 TPCN2 TRPV4 CD151 ATP1A1 ATP1A4 MEGF10 CXCR1

3.19e-0410746211GO:0098657
GeneOntologyBiologicalProcessestablishment or maintenance of transmembrane electrochemical gradient

ATP1A1 ATP1A4

4.80e-0411622GO:0010248
GeneOntologyBiologicalProcessstriated muscle contraction

CACNA1C CACNA1D TRPV4 VPS54 ATP1A1

4.89e-04217625GO:0006941
GeneOntologyBiologicalProcesscalcium ion transmembrane import into cytosol

CACNA1C CACNA1D CACNA1F TPCN2 TRPV4

4.89e-04217625GO:0097553
GeneOntologyBiologicalProcessinorganic ion homeostasis

CACNA1C CACNA1F TPCN2 P2RY1 TRPV4 VPS54 ATP1A1 ATP1A4

5.26e-04622628GO:0098771
GeneOntologyBiologicalProcessneuropeptide signaling pathway

NPY5R MRGPRX1 MRGPRX3 MRGPRX4

5.30e-04124624GO:0007218
GeneOntologyBiologicalProcesspositive regulation of cytokinesis

MRGPRX1 MRGPRX3 MRGPRX4

6.07e-0455623GO:0032467
GeneOntologyBiologicalProcessintracellular calcium ion homeostasis

CACNA1C CACNA1F TPCN2 P2RY1 TRPV4 VPS54

7.21e-04359626GO:0006874
GeneOntologyBiologicalProcesscell communication involved in cardiac conduction

CACNA1C CACNA1D ATP1A1

7.46e-0459623GO:0086065
GeneOntologyBiologicalProcessacute-phase response

MRGPRX1 MRGPRX3 MRGPRX4

7.46e-0459623GO:0006953
GeneOntologyBiologicalProcesspositive regulation of muscle contraction

CACNA1C TRPV4 ATP1A1

7.46e-0459623GO:0045933
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

CACNA1C CACNA1D ATP1A1

8.62e-0462623GO:0086002
GeneOntologyBiologicalProcessacute inflammatory response

NPY5R MRGPRX1 MRGPRX3 MRGPRX4

9.05e-04143624GO:0002526
GeneOntologyBiologicalProcesspositive regulation of membrane depolarization

CACNA1C CACNA1D

1.04e-0316622GO:1904181
GeneOntologyBiologicalProcesscalcium ion homeostasis

CACNA1C CACNA1F TPCN2 P2RY1 TRPV4 VPS54

1.09e-03389626GO:0055074
GeneOntologyBiologicalProcesschemical homeostasis

CACNA1C CACNA1D CACNA1F SLC9C1 TPCN2 P2RY1 TRPV4 HMGCR VPS54 ATP1A1 ATP1A4

1.12e-0312496211GO:0048878
GeneOntologyBiologicalProcessintracellular potassium ion homeostasis

ATP1A1 ATP1A4

1.17e-0317622GO:0030007
GeneOntologyBiologicalProcesspositive regulation of striated muscle contraction

TRPV4 ATP1A1

1.17e-0317622GO:0045989
GeneOntologyBiologicalProcesssodium ion export across plasma membrane

ATP1A1 ATP1A4

1.17e-0317622GO:0036376
GeneOntologyBiologicalProcesssecretion by cell

CACNA1C CACNA1D TPCN2 NPY5R P2RY1 MRGPRX1 MRGPRX3 TRPV4 MRGPRX4 HMGCR

1.19e-0310646210GO:0032940
GeneOntologyBiologicalProcessmuscle system process

CACNA1C CACNA1D TPCN2 P2RY1 TRPV4 VPS54 ATP1A1

1.24e-03547627GO:0003012
GeneOntologyBiologicalProcessmuscle contraction

CACNA1C CACNA1D TPCN2 TRPV4 VPS54 ATP1A1

1.26e-03400626GO:0006936
GeneOntologyBiologicalProcesssodium ion transport

SLC9C1 TPCN2 SLC5A7 ATP1A1 ATP1A4

1.41e-03275625GO:0006814
GeneOntologyBiologicalProcessmast cell degranulation

MRGPRX1 MRGPRX3 MRGPRX4

1.44e-0374623GO:0043303
GeneOntologyBiologicalProcessmast cell mediated immunity

MRGPRX1 MRGPRX3 MRGPRX4

1.56e-0376623GO:0002448
GeneOntologyBiologicalProcessmast cell activation involved in immune response

MRGPRX1 MRGPRX3 MRGPRX4

1.68e-0378623GO:0002279
GeneOntologyBiologicalProcessregulated exocytosis

CACNA1C P2RY1 MRGPRX1 MRGPRX3 MRGPRX4

1.81e-03291625GO:0045055
GeneOntologyBiologicalProcessexocytosis

CACNA1C TPCN2 P2RY1 MRGPRX1 MRGPRX3 MRGPRX4

1.91e-03434626GO:0006887
GeneOntologyBiologicalProcessregulation of calcium ion transmembrane transport via high voltage-gated calcium channel

CACNA1C CACNA1D

1.98e-0322622GO:1902514
GeneOntologyBiologicalProcessmembrane depolarization during cardiac muscle cell action potential

CACNA1C CACNA1D

2.16e-0323622GO:0086012
GeneOntologyBiologicalProcesscalcium ion transmembrane transport via high voltage-gated calcium channel

CACNA1C CACNA1D

2.16e-0323622GO:0061577
GeneOntologyBiologicalProcesscardiac muscle cell action potential

CACNA1C CACNA1D ATP1A1

2.29e-0387623GO:0086001
GeneOntologyBiologicalProcessmonoatomic ion transport

CACNA1C CACNA1D CACNA1F SLC9C1 TPCN2 P2RY1 SLC5A7 TRPV4 ATP1A1 TMC5 ATP1A4

2.41e-0313746211GO:0006811
GeneOntologyCellularComponentneuronal cell body membrane

MRGPRX1 MRGPRX3 MRGPRX4

3.54e-0443673GO:0032809
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1C CACNA1D CACNA1F

4.33e-0446673GO:0005891
GeneOntologyCellularComponentcell body membrane

MRGPRX1 MRGPRX3 MRGPRX4

4.61e-0447673GO:0044298
GeneOntologyCellularComponentL-type voltage-gated calcium channel complex

CACNA1C CACNA1D

6.54e-0412672GO:1990454
GeneOntologyCellularComponentsodium:potassium-exchanging ATPase complex

ATP1A1 ATP1A4

6.54e-0412672GO:0005890
GeneOntologyCellularComponentcalcium channel complex

CACNA1C CACNA1D CACNA1F

1.67e-0373673GO:0034704
GeneOntologyCellularComponentT-tubule

CACNA1C CACNA1D ATP1A1

2.09e-0379673GO:0030315
HumanPhenoAreflexia

MPZ SLC5A7 TRPV4 HMGCR ATP1A1 MEGF10

8.90e-06314106HP:0001284
HumanPhenoProximal muscle weakness

MPZ SLC5A7 TRPV4 HMGCR ATP1A1 MEGF10

1.41e-05340106HP:0003701
HumanPhenoLimb muscle weakness

MPZ SLC5A7 TRPV4 HMGCR ATP1A1 MEGF10

1.94e-05359106HP:0003690
HumanPhenoHyporeflexia

MPZ SLC5A7 TRPV4 HMGCR ATP1A1 MEGF10

4.34e-05413106HP:0001265
HumanPhenoStridor

CACNA1C SLC5A7 TRPV4

1.02e-0450103HP:0010307
HumanPhenoAbnormality of peripheral nerve conduction

MPZ SLC5A7 TRPV4 MEGF10

1.29e-04149104HP:0003134
HumanPhenoAbnormal peripheral nerve morphology by anatomical site

MPZ SLC5A7 TRPV4 MEGF10

1.46e-04154104HP:0045010
HumanPhenoAbnormal motor nerve conduction velocity

MPZ SLC5A7 MEGF10

2.55e-0468103HP:0040131
HumanPhenoSkeletal muscle atrophy

MPZ SLC5A7 TRPV4 HMGCR ATP1A1 MEGF10

2.95e-04579106HP:0003202
HumanPhenoProximal muscle weakness in lower limbs

MPZ TRPV4 HMGCR ATP1A1

3.04e-04186104HP:0008994
HumanPhenoObstructive sleep apnea

CACNA1C SLC5A7 TRPV4

3.98e-0479103HP:0002870
HumanPhenoHypokalemia

CACNA1C CACNA1D ATP1A1

3.98e-0479103HP:0002900
HumanPhenoReduced tendon reflexes

MPZ SLC5A7 TRPV4 HMGCR ATP1A1 MEGF10

4.21e-04617106HP:0001315
HumanPhenoUpper limb amyotrophy

MPZ TRPV4 HMGCR

4.61e-0483103HP:0009129
HumanPhenoDiaphragmatic weakness

TRPV4 MEGF10

4.64e-0417102HP:0009113
HumanPhenoAbnormality of the musculature of the limbs

MPZ SLC5A7 TRPV4 HMGCR ATP1A1 MEGF10

6.01e-04658106HP:0009127
HumanPhenoDistal amyotrophy

MPZ SLC5A7 TRPV4 ATP1A1

6.86e-04230104HP:0003693
HumanPhenoDistal lower limb muscle weakness

MPZ SLC5A7 TRPV4

7.07e-0496103HP:0009053
HumanPhenoFacial palsy

MPZ SLC5A7 TRPV4 MEGF10

7.09e-04232104HP:0010628
HumanPhenoAbnormal seventh cranial physiology

MPZ SLC5A7 TRPV4 MEGF10

7.20e-04233104HP:0010827
HumanPhenoDecreased fetal movement

MPZ SLC5A7 TRPV4 MEGF10

7.32e-04234104HP:0001558
HumanPhenoJuvenile onset

CACNA1C MPZ SLC5A7 TRPV4 HMGCR ATP1A1

8.46e-04700106HP:0003621
HumanPhenoRespiratory insufficiency due to muscle weakness

MPZ SLC5A7 HMGCR

8.69e-04103103HP:0002747
HumanPhenoPrenatal movement abnormality

MPZ SLC5A7 TRPV4 MEGF10

8.85e-04246104HP:0001557
HumanPhenoAbnormality of skeletal muscles

MPZ SLC5A7 TRPV4 HMGCR ATP1A1 MEGF10

1.04e-03727106HP:0040290
HumanPhenoAmyotrophy involving the extremities

MPZ TRPV4 HMGCR

1.11e-03112103HP:0003671
HumanPhenoAbnormal blood potassium concentration

CACNA1C CACNA1D ATP1A1

1.14e-03113103HP:0011042
HumanPhenoAbnormality of muscle size

MPZ SLC5A7 TRPV4 HMGCR ATP1A1 MEGF10

1.15e-03740106HP:0030236
HumanPhenoWeakness of muscles of respiration

MPZ SLC5A7 HMGCR

1.23e-03116103HP:0004347
HumanPhenoWeakness of facial musculature

MPZ SLC5A7 TRPV4 MEGF10

1.24e-03269104HP:0030319
HumanPhenoAbnormal nerve conduction velocity

MPZ SLC5A7 MEGF10

1.32e-03119103HP:0040129
HumanPhenoAbnormal motor neuron morphology

MPZ SLC5A7 TRPV4 HMGCR ATP1A1

1.49e-03501105HP:0002450
HumanPhenoCentral sleep apnea

CACNA1C SLC5A7

1.56e-0331102HP:0010536
HumanPhenoAbnormal neuron morphology

MPZ SLC5A7 TRPV4 HMGCR ATP1A1

1.58e-03507105HP:0012757
HumanPhenoIncreased endomysial connective tissue

HMGCR MEGF10

1.67e-0332102HP:0100297
HumanPhenoAbnormality of the musculature of the lower limbs

MPZ TRPV4 HMGCR ATP1A1

1.80e-03297104HP:0001437
HumanPhenoAbnormal breath sound

CACNA1C SLC5A7 TRPV4

1.83e-03133103HP:0030829
HumanPhenoAbnormal muscle fiber morphology

SLC5A7 TRPV4 HMGCR MEGF10

1.91e-03302104HP:0004303
HumanPhenoPes cavus

MPZ SLC5A7 TRPV4 ATP1A1

1.96e-03304104HP:0001761
HumanPhenoElevated circulating creatine kinase concentration

MPZ TRPV4 HMGCR MEGF10

2.01e-03306104HP:0003236
HumanPhenoAbnormal fetal physiology

MPZ SLC5A7 TRPV4 MEGF10

2.06e-03308104HP:0034059
HumanPhenoEMG: impaired neuromuscular transmission

CACNA1D SLC5A7

2.11e-0336102HP:0100285
HumanPhenoAbnormality of peripheral nervous system electrophysiology

MPZ SLC5A7 TRPV4 MEGF10

2.24e-03315104HP:0030177
HumanPhenoFoot dorsiflexor weakness

MPZ TRPV4 ATP1A1

2.29e-03144103HP:0009027
HumanPhenoAbnormal peripheral nervous system physiology

MPZ SLC5A7 TRPV4 MEGF10

2.34e-03319104HP:0032120
HumanPhenoMotor polyneuropathy

SLC5A7 TRPV4

2.35e-0338102HP:0007178
HumanPhenoAbnormal circulating creatine kinase concentration

MPZ TRPV4 HMGCR MEGF10

2.43e-03322104HP:0040081
HumanPhenoAbnormal circulating enzyme concentration

MPZ TRPV4 HMGCR MEGF10

2.60e-03328104HP:0011021
HumanPhenoDysphagia

CACNA1C MPZ SLC5A7 HMGCR MEGF10

2.62e-03567105HP:0002015
HumanPhenoCranial nerve paralysis

MPZ SLC5A7 TRPV4 MEGF10

2.63e-03329104HP:0006824
HumanPhenoUpper limb muscle weakness

MPZ TRPV4 HMGCR

2.63e-03151103HP:0003484
HumanPhenoAbnormality of the foot musculature

MPZ TRPV4 ATP1A1

2.63e-03151103HP:0001436
HumanPhenoAbnormal cranial nerve physiology

MPZ SLC5A7 TRPV4 MEGF10

2.72e-03332104HP:0031910
HumanPhenoAbnormal blood monovalent inorganic cation concentration

CACNA1C CACNA1D ATP1A1

2.78e-03154103HP:0010930
HumanPhenoFetal anomaly

CACNA1C MPZ SLC5A7 TRPV4 MEGF10

2.79e-03575105HP:0034057
HumanPhenoParalysis

SLC5A7 TRPV4 MEGF10

3.05e-03159103HP:0003470
HumanPhenoSlowly progressive

MPZ SLC5A7 ATP1A1

3.16e-03161103HP:0003677
MousePhenodecreased pruritus

MRGPRX1 MRGPRX3 MRGPRX4

2.51e-077283MP:0010073
MousePhenoabnormal pruritus

MRGPRX1 MRGPRX3 MRGPRX4

1.56e-0612283MP:0010071
MousePhenoabnormal neuron physiology

CACNA1C CACNA1D CACNA1F MRGPRX1 MRGPRX3 TRPV4 MRGPRX4 VPS54

1.67e-05604288MP:0004811
MousePhenoabnormal skin physiology

CACNA1C MRGPRX1 MRGPRX3 TRPV4 MRGPRX4 CD151

1.87e-05288286MP:0005501
Domain7tm_1

OR10A3 OR2W3 OR51T1 OR5T1 OR4S1 OR13D1 NPY5R P2RY1 OR13C5 MRGPRX1 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR10A6 OR2D2 MRGPRX3 OR10H4 MRGPRX4 OR2J1 OR6K3 OR4C12 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 CXCR1 OR4F6

2.17e-326775933PF00001
DomainG_PROTEIN_RECEP_F1_1

OR10A3 OR2W3 OR51T1 OR5T1 OR4S1 OR13D1 NPY5R P2RY1 OR13C5 MRGPRX1 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR10A6 OR2D2 MRGPRX3 OR10H4 MRGPRX4 OR2J1 OR6K3 OR4C12 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 CXCR1 OR4F6

3.19e-326855933PS00237
DomainG_PROTEIN_RECEP_F1_2

OR10A3 OR2W3 OR51T1 OR5T1 OR4S1 OR13D1 NPY5R P2RY1 OR13C5 MRGPRX1 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR10A6 OR2D2 MRGPRX3 OR10H4 MRGPRX4 OR2J1 OR6K3 OR4C12 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 CXCR1 OR4F6

4.25e-326915933PS50262
DomainGPCR_Rhodpsn

OR10A3 OR2W3 OR51T1 OR5T1 OR4S1 OR13D1 NPY5R P2RY1 OR13C5 MRGPRX1 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR10A6 OR2D2 MRGPRX3 OR10H4 MRGPRX4 OR2J1 OR6K3 OR4C12 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 CXCR1 OR4F6

4.46e-326925933IPR000276
DomainGPCR_Rhodpsn_7TM

OR10A3 OR2W3 OR51T1 OR5T1 OR4S1 OR13D1 NPY5R P2RY1 OR13C5 MRGPRX1 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR10A6 OR2D2 MRGPRX3 OR10H4 MRGPRX4 OR6K3 OR4C12 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 CXCR1 OR4F6

5.33e-316705932IPR017452
DomainOlfact_rcpt

OR10A3 OR2W3 OR51T1 OR5T1 OR4S1 OR13D1 OR13C5 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR10A6 OR2D2 OR10H4 OR2J1 OR6K3 OR4C12 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 OR4F6

5.67e-303935927IPR000725
DomainCAC1F_C

CACNA1C CACNA1D CACNA1F

2.99e-083593PF16885
DomainCAC1F_C

CACNA1C CACNA1D CACNA1F

2.99e-083593IPR031688
DomainVDCC_L_a1su

CACNA1C CACNA1D CACNA1F

1.20e-074593IPR005446
DomainGPHH_dom

CACNA1C CACNA1D CACNA1F

1.04e-067593IPR031649
DomainVDCC_a1su_IQ

CACNA1C CACNA1D CACNA1F

1.04e-067593IPR014873
DomainCa_chan_IQ

CACNA1C CACNA1D CACNA1F

1.04e-067593SM01062
DomainCa_chan_IQ

CACNA1C CACNA1D CACNA1F

1.04e-067593PF08763
DomainGPHH

CACNA1C CACNA1D CACNA1F

1.04e-067593PF16905
DomainIon_trans_dom

CACNA1C CACNA1D CACNA1F SLC9C1 TPCN2 TRPV4

1.57e-06114596IPR005821
DomainIon_trans

CACNA1C CACNA1D CACNA1F SLC9C1 TPCN2 TRPV4

1.57e-06114596PF00520
DomainVDCCAlpha1

CACNA1C CACNA1D CACNA1F

3.54e-0610593IPR002077
DomainMRGPCRFAMILY

MRGPRX1 MRGPRX3 MRGPRX4

4.85e-0611593IPR026234
DomainChannel_four-helix_dom

CACNA1C CACNA1D CACNA1F TPCN2

3.13e-0557594IPR027359
Domain-

CACNA1C CACNA1D CACNA1F TPCN2

3.13e-05575941.20.120.350
DomainP-type_ATPase_IIC

ATP1A1 ATP1A4

1.46e-046592IPR005775
Domain-

ATP1A1 ATP1A4

1.14e-03165921.20.1110.10
DomainATPase_P-typ_TM_dom

ATP1A1 ATP1A4

1.14e-0316592IPR023298
DomainATPase_P-typ_cation-transptr_C

ATP1A1 ATP1A4

1.29e-0317592IPR006068
DomainCation_ATPase_C

ATP1A1 ATP1A4

1.29e-0317592PF00689
DomainCation_ATPase_N

ATP1A1 ATP1A4

1.45e-0318592PF00690
DomainCation_ATPase_N

ATP1A1 ATP1A4

1.45e-0318592SM00831
DomainATPase_P-typ_cation-transptr_N

ATP1A1 ATP1A4

1.62e-0319592IPR004014
DomainTM4_1

TSPAN15 CD151

3.04e-0326592PS00421
DomainTetraspanin

TSPAN15 CD151

4.58e-0332592IPR000301
DomainTetraspanin_EC2

TSPAN15 CD151

4.58e-0332592IPR008952
Domain-

ATP1A1 ATP1A4

4.58e-03325922.70.150.10
Domain-

ATP1A1 ATP1A4

4.58e-03325923.40.1110.10
DomainTetraspannin

TSPAN15 CD151

4.86e-0333592PF00335
DomainTetraspanin/Peripherin

TSPAN15 CD151

4.86e-0333592IPR018499
DomainATPase_P-typ_cyto_domN

ATP1A1 ATP1A4

5.46e-0335592IPR023299
DomainATPase_P-typ_P_site

ATP1A1 ATP1A4

5.77e-0336592IPR018303
DomainP_typ_ATPase

ATP1A1 ATP1A4

5.77e-0336592IPR001757
DomainATPASE_E1_E2

ATP1A1 ATP1A4

5.77e-0336592PS00154
DomainATPase_P-typ_transduc_dom_A

ATP1A1 ATP1A4

6.09e-0337592IPR008250
DomainE1-E2_ATPase

ATP1A1 ATP1A4

6.09e-0337592PF00122
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR10A3 OR2W3 OR51T1 OR5T1 OR4S1 OR13D1 OR13C5 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR1P1 OR10A6 OR2D2 OR10H4 OR2J1 OR6K3 OR4C12 OR10J4 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 OR4F6

6.17e-304175629M4072
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR10A3 OR2W3 OR51T1 OR5T1 OR4S1 OR13D1 OR13C5 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR10A6 OR2D2 OR10H4 OR6K3 OR4C12 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 OR4F6

3.94e-263895626M14091
PathwayREACTOME_SENSORY_PERCEPTION

OR10A3 OR2W3 OR51T1 CACNA1D OR5T1 OR4S1 OR13D1 OR13C5 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR1P1 OR10A6 OR2D2 OR10H4 OR2J1 OR6K3 OR4C12 OR10J4 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 OR4F6

4.82e-266365630M41834
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR10A3 OR2W3 OR10A6 OR2J1 OR4C12 OR56A4 OR4L1

1.05e-0870567MM14984
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1C CACNA1D CACNA1F

1.18e-066563M47762
PathwayREACTOME_SENSORY_PERCEPTION

OR10A3 OR2W3 OR10A6 OR2J1 OR4C12 OR56A4 OR4L1

9.60e-06190567MM15687
PathwayKEGG_CARDIAC_MUSCLE_CONTRACTION

CACNA1C CACNA1D CACNA1F ATP1A1 ATP1A4

1.49e-0579565M17673
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01004

CACNA1C CACNA1D CACNA1F

2.10e-0514563M47692
PathwayWP_GPCRS_ODORANT

OR5T1 MRGPRX1 MRGPRX3 OR10H4 MRGPRX4 OR2B6

3.56e-05157566MM15872
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1C CACNA1D CACNA1F

9.94e-0523563M47666
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1C CACNA1D CACNA1F

1.28e-0425563M47948
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

NPY5R P2RY1 OR2D2 OR2J1 OR2B6 CXCR1

5.57e-04260566M39397
PathwayREACTOME_ION_CHANNEL_TRANSPORT

SLC9C1 TPCN2 TRPV4 ATP1A1 ATP1A4

7.80e-04183565M997
PathwayWP_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY

CACNA1C CACNA1D CACNA1F

3.15e-0374563M39462
PathwayWP_ALZHEIMERS_DISEASE

CACNA1C CACNA1D CACNA1F

3.15e-0374563MM15962
PathwayKEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC

CACNA1C CACNA1D CACNA1F

3.15e-0374563M16376
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR10A3 OR2W3 OR51T1 OR5T1 OR13D1 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR1P1 OR10A6 OR2D2 OR10H4 OR5AK3P OR2J1 OR6K3 OR4C12 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR6K6 OR4L1 OR4F6 OR2W6P

7.01e-37343672732295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR10A3 OR2W3 OR51T1 OR5T1 OR13D1 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR1P1 OR10A6 OR2D2 OR10H4 OR5AK3P OR2J1 OR6K3 OR4C12 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR6K6 OR4L1 OR4F6 OR2W6P

8.92e-37346672714611657
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR10A3 OR2W3 OR51T1 OR5T1 OR13D1 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR1P1 OR10A6 OR2D2 OR10H4 OR5AK3P OR2J1 OR6K3 OR4C12 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR4L1 OR4F6 OR2W6P

3.97e-35340672611875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR10A3 OR2W3 OR51T1 OR5T1 OR13D1 OR4A47 OR9Q2 OR52E8 OR10K1 OR2D3 OR1P1 OR10A6 OR2D2 OR10H4 OR5AK3P OR2J1 OR6K3 OR4C12 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR4L1 OR4F6 OR2W6P

3.97e-35340672611802173
Pubmed

The human olfactory receptor gene family.

OR10A3 OR2W3 OR51T1 OR5T1 OR4S1 OR13D1 OR13C5 OR4A47 OR52E8 OR10K1 OR2D3 OR1P1 OR10A6 OR2D2 OR10H4 OR2J1 OR6K3 OR4C12 OR56A4 OR5M3 OR5M11 OR52K2 OR2B6 OR1L3 OR6K6 OR4L1 OR4F6 OR2W6P

3.92e-33541672814983052
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR10A3 OR2W3 OR4A47 OR2D3 OR1P1 OR2D2 OR10H4 OR4C12 OR10J4 OR5M3 OR5M11

4.52e-13219671112213199
Pubmed

bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells.

MRGPRX1 MRGPRX3 MRGPRX4

6.83e-09367310662793
Pubmed

Activation of mas-related G-protein-coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation.

MRGPRX1 MRGPRX3 MRGPRX4

6.83e-09367328768771
Pubmed

The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms.

MRGPRX1 MRGPRX3 MRGPRX4

6.83e-09367326022362
Pubmed

Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways.

MRGPRX1 MRGPRX3 MRGPRX4

6.83e-09367327215903
Pubmed

Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions.

MRGPRX1 MRGPRX3 MRGPRX4

6.83e-09367318250432
Pubmed

Mas-related G protein-coupled receptor C11 (Mrgprc11) induces visceral hypersensitivity in the mouse colon: A novel target in gut nociception?

MRGPRX1 MRGPRX3 MRGPRX4

6.83e-09367331119828
Pubmed

Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs.

MRGPRX1 MRGPRX3 MRGPRX4

6.83e-09367311850634
Pubmed

Overlap of direct and indirect alloreactive T-cell repertoires when MHC polymorphism is limited to the peptide binding groove.

MRGPRX1 MRGPRX3 MRGPRX4

2.73e-08467311821156
Pubmed

Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain.

MRGPRX1 MRGPRX3 MRGPRX4

2.73e-08467317975009
Pubmed

Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways.

MRGPRX1 MRGPRX3 MRGPRX4

2.73e-08467323074220
Pubmed

Characterization of new G protein-coupled adenine receptors in mouse and hamster.

MRGPRX1 MRGPRX3 MRGPRX4

2.73e-08467323608776
Pubmed

The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia.

MRGPRX1 MRGPRX3 MRGPRX4

2.73e-08467321775281
Pubmed

Voltage-gated potassium channels involved in regulation of physiological function in MrgprA3-specific itch neurons.

MRGPRX1 MRGPRX3 MRGPRX4

2.73e-08467326874069
Pubmed

Tick peptides evoke itch by activating MrgprC11/MRGPRX1 to sensitize TRPV1 in pruriceptors.

MRGPRX1 MRGPRX3 MRGPRX4

2.73e-08467333358893
Pubmed

MrgprA3 shows sensitization to chloroquine in an acetone-ether-water mice model.

MRGPRX1 MRGPRX3 MRGPRX4

2.73e-08467329064954
Pubmed

USP48 alleviates bone cancer pain and regulates MrgC stabilization in spinal cord neurons of male mice.

MRGPRX1 MRGPRX3 MRGPRX4

2.73e-08467336864656
Pubmed

Low maternal care enhances the skin barrier resistance of offspring in mice.

MRGPRX1 MRGPRX3 MRGPRX4

2.73e-08467331295326
Pubmed

Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.

CACNA1C CACNA1D CACNA1F

2.73e-08467320937870
Pubmed

Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension.

MRGPRX1 MRGPRX3 MRGPRX4

2.73e-08467333727332
Pubmed

A fraction of mouse sperm chromatin is organized in nucleosomal hypersensitive domains enriched in retroposon DNA.

MRGPRX1 MRGPRX3 MRGPRX4

2.73e-08467310504302
Pubmed

A mechanically activated ion channel is functionally expressed in the MrgprB4 positive sensory neurons, which detect stroking of hairy skin in mice.

MRGPRX1 MRGPRX3 MRGPRX4

2.73e-08467328545921
Pubmed

Substance P activates Mas-related G protein-coupled receptors to induce itch.

MRGPRX1 MRGPRX3 MRGPRX4

2.73e-08467328219706
Pubmed

Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection.

MRGPRX1 MRGPRX3 MRGPRX4

2.73e-08467335882236
Pubmed

Molecular Signature of Pruriceptive MrgprA3+ Neurons.

MRGPRX1 MRGPRX3 MRGPRX4

2.73e-08467332234460
Pubmed

Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus.

MRGPRX1 MRGPRX3 MRGPRX4

6.81e-08567320004959
Pubmed

Hippocampal short- and long-term plasticity are not modulated by astrocyte Ca2+ signaling.

MRGPRX1 MRGPRX3 MRGPRX4

6.81e-08567320203048
Pubmed

Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch.

MRGPRX1 MRGPRX3 MRGPRX4

6.81e-08567317618277
Pubmed

STAG3, a novel gene encoding a protein involved in meiotic chromosome pairing and location of STAG3-related genes flanking the Williams-Beuren syndrome deletion.

STAG3L1 STAG3L2 STAG3L3

6.81e-08567310698974
Pubmed

Regional Differences in Itch Transmission.

MRGPRX1 MRGPRX3 MRGPRX4

6.81e-08567338735364
Pubmed

MrgprB4 in trigeminal neurons expressing TRPA1 modulates unpleasant sensations.

MRGPRX1 MRGPRX3 MRGPRX4

6.81e-08567334116733
Pubmed

Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+.

MRGPRX1 MRGPRX3 MRGPRX4

6.81e-08567322472648
Pubmed

Cross-sensitization of histamine-independent itch in mouse primary sensory neurons.

MRGPRX1 MRGPRX3 MRGPRX4

6.81e-08567323000623
Pubmed

Genetic identification of C fibres that detect massage-like stroking of hairy skin in vivo.

MRGPRX1 MRGPRX3 MRGPRX4

1.36e-07667323364746
Pubmed

A subpopulation of nociceptors specifically linked to itch.

MRGPRX1 MRGPRX3 MRGPRX4

1.36e-07667323263443
Pubmed

Identification of a bilirubin receptor that may mediate a component of cholestatic itch.

MRGPRX1 MRGPRX3 MRGPRX4

1.36e-07667330657454
Pubmed

Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain.

MRGPRX1 MRGPRX3 MRGPRX4

1.36e-07667324549959
Pubmed

Visualizing the Itch-Sensing Skin Arbors.

MRGPRX1 MRGPRX3 MRGPRX4

1.36e-07667333091423
Pubmed

Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs.

MRGPRX1 MRGPRX3 MRGPRX4

1.36e-07667326216096
Pubmed

MrgprC11+ sensory neurons mediate glabrous skin itch.

MRGPRX1 MRGPRX3 MRGPRX4

1.36e-07667333876765
Pubmed

Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity.

MRGPRX1 MRGPRX3 MRGPRX4

2.38e-07767336693373
Pubmed

Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.

CACNA1C CACNA1D CACNA1F

2.38e-07767312900400
Pubmed

Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes.

MRGPRX1 MRGPRX3 MRGPRX4

3.80e-07867324583173
Pubmed

Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family.

MRGPRX1 MRGPRX3 MRGPRX4

3.80e-07867312909716
Pubmed

Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway.

MRGPRX1 MRGPRX3 MRGPRX4

5.69e-07967312397184
Pubmed

Multiplexed peroxidase-based electron microscopy labeling enables simultaneous visualization of multiple cell types.

MRGPRX1 MRGPRX3 MRGPRX4

5.69e-07967330886406
Pubmed

Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens.

MRGPRX1 MRGPRX3 MRGPRX4

8.12e-071067333098765
Pubmed

A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons.

MRGPRX1 MRGPRX3 MRGPRX4

1.12e-061167311551509
Pubmed

NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.

CACNA1C CACNA1D CACNA1F

1.12e-061167318809727
Pubmed

An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates.

MRGPRX1 MRGPRX3 MRGPRX4

1.12e-061167321151121
Pubmed

Parallel ascending spinal pathways for affective touch and pain.

MRGPRX1 MRGPRX3 MRGPRX4

2.45e-061467333116307
Pubmed

A brain-to-spinal sensorimotor loop for repetitive self-grooming.

MRGPRX1 MRGPRX3 MRGPRX4

3.06e-061567334932943
Pubmed

Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

CACNA1C CACNA1D CACNA1F

3.06e-061567320188150
Pubmed

DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon.

MRGPRX1 MRGPRX3 MRGPRX4

3.06e-061567337541195
Pubmed

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

CACNA1C CACNA1D CACNA1F

3.06e-061567324453333
Pubmed

P2Y1 Receptor Activation of the TRPV4 Ion Channel Enhances Purinergic Signaling in Satellite Glial Cells.

P2RY1 TRPV4

3.66e-06267226475857
Pubmed

Genetic, cellular, and functional evidence for Ca2+ inflow through Cav1.2 and Cav1.3 channels in murine spiral ganglion neurons.

CACNA1C CACNA1D

3.66e-06267224849370
Pubmed

Deletion of the L-type calcium channel Ca(V) 1.3 but not Ca(V) 1.2 results in a diminished sAHP in mouse CA1 pyramidal neurons.

CACNA1C CACNA1D

3.66e-06267220014384
Pubmed

Differential zinc permeation and blockade of L-type Ca2+ channel isoforms Cav1.2 and Cav1.3.

CACNA1C CACNA1D

3.66e-06267226049024
Pubmed

Divide and conquer: an L-type voltage-gated calcium channel subtype finds a role in conditioned fear.

CACNA1C CACNA1D

3.66e-06267217015854
Pubmed

Role of putative voltage-sensor countercharge D4 in regulating gating properties of CaV1.2 and CaV1.3 calcium channels.

CACNA1C CACNA1D

3.66e-06267230001160
Pubmed

Genetic polymorphisms of L-type calcium channel alpha1C and alpha1D subunit genes are associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium-channel blockers.

CACNA1C CACNA1D

3.66e-06267219225208
Pubmed

Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB.

CACNA1C CACNA1D

3.66e-06267216706838
Pubmed

Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures.

CACNA1C CACNA1D

3.66e-06267223761887
Pubmed

Non-voltage-gated L-type Ca2+ channels in human T cells: pharmacology and molecular characterization of the major alpha pore-forming and auxiliary beta-subunits.

CACNA1C CACNA1D

3.66e-06267214981074
Pubmed

Rescue and worsening of congenital heart block-associated electrocardiographic abnormalities in two transgenic mice.

CACNA1C CACNA1D

3.66e-06267221352396
Pubmed

CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serum.

CACNA1C CACNA1D

3.66e-06267225292336
Pubmed

Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension.

CACNA1D ATP1A1

3.66e-06267223913004
Pubmed

Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle.

CACNA1C CACNA1D

3.66e-06267217526649
Pubmed

Ligand-activated signal transduction in the 2-cell embryo.

CACNA1C CACNA1D

3.66e-06267212606379
Pubmed

Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators.

CACNA1C CACNA1D

3.66e-06267224941892
Pubmed

Different roles attributed to Cav1 channel subtypes in spontaneous action potential firing and fine tuning of exocytosis in mouse chromaffin cells.

CACNA1C CACNA1D

3.66e-06267221054386
Pubmed

Molecular nature of anomalous L-type calcium channels in mouse cerebellar granule cells.

CACNA1C CACNA1D

3.66e-06267217409250
Pubmed

Neuronal L-type calcium channels open quickly and are inhibited slowly.

CACNA1C CACNA1D

3.66e-06267216267232
Pubmed

Cav1.2 and Cav1.3 L-type calcium channels regulate dopaminergic firing activity in the mouse ventral tegmental area.

CACNA1C CACNA1D

3.66e-06267224848473
Pubmed

Equal sensitivity of Cav1.2 and Cav1.3 channels to the opposing modulations of PKA and PKG in mouse chromaffin cells.

CACNA1C CACNA1D

3.66e-06267222826131
Pubmed

C-terminal modulator controls Ca2+-dependent gating of Ca(v)1.4 L-type Ca2+ channels.

CACNA1D CACNA1F

3.66e-06267216921373
Pubmed

The role of L-type voltage-gated calcium channels Cav1.2 and Cav1.3 in normal and pathological brain function.

CACNA1C CACNA1D

3.66e-06267224996399
Pubmed

Transcriptional regulation of L-type calcium channel subtypes Cav1.2 and Cav1.3 by nicotine and their potential role in nicotine sensitization.

CACNA1C CACNA1D

3.66e-06267224470632
Pubmed

Voltage-Gated Cav1 Channels in Disorders of Vision and Hearing.

CACNA1D CACNA1F

3.66e-06267225966695
Pubmed

Cav1.2 and Cav1.3 L-type calcium channels operate in a similar voltage range but show different coupling to Ca(2+)-dependent conductances in hippocampal neurons.

CACNA1C CACNA1D

3.66e-06267224760982
Pubmed

An improved targeted cAMP sensor to study the regulation of adenylyl cyclase 8 by Ca2+ entry through voltage-gated channels.

CACNA1C CACNA1D

3.66e-06267224086669
Pubmed

Incoherent feed-forward regulatory loops control segregation of C-mechanoreceptors, nociceptors, and pruriceptors.

MRGPRX1 MRGPRX3 MRGPRX4

4.56e-061767325834056
Pubmed

p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling.

MRGPRX1 MRGPRX3 MRGPRX4

5.46e-061867329045838
Pubmed

C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway.

MRGPRX1 MRGPRX3 MRGPRX4

6.48e-061967338915692
Pubmed

Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors.

MRGPRX1 MRGPRX3 MRGPRX4

6.48e-061967322787056
Pubmed

Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor.

MRGPRX1 MRGPRX3 MRGPRX4

6.48e-061967324516396
Pubmed

Meis1 Regulates Nociceptor Development and Behavioral Response to Tactile Stimuli.

MRGPRX1 MRGPRX3 MRGPRX4

7.61e-062067335875660
Pubmed

Hierarchical Specification of Pruriceptors by Runt-Domain Transcription Factor Runx1.

MRGPRX1 MRGPRX3 MRGPRX4

8.87e-062167328476948
Pubmed

ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons.

MRGPRX1 MRGPRX3 MRGPRX4

8.87e-062167325369838
Pubmed

The intracellular II-III loops of Cav1.2 and Cav1.3 uncouple L-type voltage-gated Ca2+ channels from glucagon-like peptide-1 potentiation of insulin secretion in INS-1 cells via displacement from lipid rafts.

CACNA1C CACNA1D

1.10e-05367219351867
Pubmed

Novel somatic mutations and distinct molecular signature in aldosterone-producing adenomas.

CACNA1D ATP1A1

1.10e-05367226285814
Pubmed

Aldosterone-Producing Adenomas: Histopathology-Genotype Correlation and Identification of a Novel CACNA1D Mutation.

CACNA1D ATP1A1

1.10e-05367228584016
Pubmed

Truncation of murine CaV1.2 at Asp-1904 results in heart failure after birth.

CACNA1C CACNA1D

1.10e-05367221832054
Pubmed

Angiotensin II suppresses long-term depression in the lateral amygdala of mice via L-type calcium channels.

CACNA1C CACNA1D

1.10e-05367217289261
InteractionCACNA1D interactions

CACNA1C CACNA1D ATP1A1

2.32e-0524473int:CACNA1D
CytobandEnsembl 112 genes in cytogenetic band chr11p15

OR10A3 OR51T1 MRGPRX1 OR52E8 OR2D3 OR10A6 OR2D2 MRGPRX3 MRGPRX4 CD151 OR56A4 OR52K2

3.42e-115646712chr11p15
Cytoband11p15.4

OR10A3 OR51T1 OR52E8 OR2D3 OR10A6 OR2D2 OR56A4 OR52K2

5.90e-1020067811p15.4
CytobandEnsembl 112 genes in cytogenetic band chr1q23

MPZ OR10K1 OR6K3 OR10J4 ATP1A4 OR6K6

1.03e-06226676chr1q23
Cytoband11q12.1

OR5T1 OR9Q2 OR5AK3P OR5M3 OR5M11

4.04e-0616167511q12.1
Cytoband1q23.1

OR10K1 OR6K3 OR6K6

4.31e-05466731q23.1
Cytoband11p15.1

MRGPRX1 MRGPRX3 MRGPRX4

9.58e-056067311p15.1
CytobandEnsembl 112 genes in cytogenetic band chr11q12

OR5T1 OR9Q2 OR5AK3P OR5M3 OR5M11

1.53e-04345675chr11q12
Cytoband7q11.23

STAG3L1 STAG3L2 STAG3L3

3.97e-04976737q11.23
Cytoband1q23.2

OR10J4 ATP1A4

1.21e-03356721q23.2
CytobandEnsembl 112 genes in cytogenetic band chr11p11

OR4S1 OR4A47 OR4C12

1.49e-03153673chr11p11
Cytoband9q31.1

OR13D1 OR13C5

1.66e-03416729q31.1
Cytoband11p11.2

OR4S1 OR4A47

6.62e-038367211p11.2
CytobandEnsembl 112 genes in cytogenetic band chr7q11

STAG3L1 STAG3L2 STAG3L3

7.38e-03271673chr7q11
GeneFamilyOlfactory receptors, family 2

OR2W3 OR2D3 OR2D2 OR2J1 OR2B6 OR2W6P

1.98e-06113606149
GeneFamilyOlfactory receptors, family 10

OR10A3 OR10K1 OR10A6 OR10H4 OR10J4

2.60e-0666605157
GeneFamilyOlfactory receptors, family 4

OR4S1 OR4A47 OR4C12 OR4L1 OR4F6

6.82e-05129605151
GeneFamilyCalcium voltage-gated channel subunits

CACNA1C CACNA1D CACNA1F

8.56e-0526603253
GeneFamilyATPase Na+/K+ transporting subunits

ATP1A1 ATP1A4

2.25e-0476021208
GeneFamilyOlfactory receptors, family 5

OR5T1 OR5AK3P OR5M3 OR5M11

5.21e-04112604152
GeneFamilyG protein-coupled receptors, Class A orphans

MRGPRX1 MRGPRX3 MRGPRX4

2.21e-0378603262
GeneFamilyOlfactory receptors, family 13

OR13D1 OR13C5

2.62e-0323602162
GeneFamilyC2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors

SCARA3 MEGF10

3.60e-03276021253
GeneFamilyCD molecules|Tetraspanins

TSPAN15 CD151

5.35e-0333602768
GeneFamilyOlfactory receptors, family 1

OR1P1 OR1L3

7.79e-0340602147
GeneFamilyCD molecules|I-set domain containing|Immunoglobulin like domain containing|Interleukin receptors|TIR domain containing

IL1RAPL2 CXCR1

8.56e-0342602602
GeneFamilyOlfactory receptors, family 52

OR52E8 OR52K2

1.15e-0249602165
GeneFamilyOlfactory receptors, family 6

OR6K3 OR6K6

1.24e-0251602153
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MPZ IL1RAPL2 SLC5A7 LRRTM3 MEGF10

3.65e-06162645d28b2ea1d2c8f3c6a107991573471b6d0c49c4ae
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MPZ IL1RAPL2 SLC5A7 LRRTM3 MEGF10

3.65e-06162645eed223e61c8162a2fe004ab4e09de5e037be7553
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MPZ IL1RAPL2 SLC5A7 LRRTM3 MEGF10

3.65e-061626455bbd7130d4dad9035e73a439dda568195c136f31
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MPZ IL1RAPL2 SLC5A7 LRRTM3 MEGF10

3.65e-06162645e35ddce830e20ebeac1a2c405293fc4a5323dd4a
ToppCellPCW_13-14-Neuronal-Neuronal_SCP-neuro_SCP_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TSPAN15 MPZ IL1RAPL2 SLC5A7 MEGF10

5.18e-061746450d8e737860120dcd3a6b57992c612595904d585e
ToppCellPCW_13-14-Neuronal-Neuronal_SCP|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TSPAN15 MPZ IL1RAPL2 SLC5A7 MEGF10

5.63e-06177645621dd82f1393c961d4dd7a615aa52c9df9e36336
ToppCell5'-Adult-LargeIntestine-Neuronal-Glial_mature|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MPZ IL1RAPL2 SLC5A7 SCARA3 MEGF10

6.97e-06185645f607b6ee579562e2f92103fa5c7053df0170a229
ToppCell5'-Adult-LargeIntestine-Neuronal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MPZ IL1RAPL2 SLC5A7 SCARA3 MEGF10

6.97e-06185645317f2c854f00aa5957319b818c85eeed7d72ec7f
ToppCell5'-Adult-LargeIntestine-Neuronal-Glial_mature-Adult_Glia|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MPZ IL1RAPL2 SLC5A7 SCARA3 MEGF10

6.97e-061856457bb8fdfe04f85d25056380ec58222366de323a21
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA1D SGSM1 IL1RAPL2 USP24 ATP1A1

7.54e-06188645bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA1D SGSM1 IL1RAPL2 USP24 ATP1A1

7.74e-06189645977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA1D SGSM1 IL1RAPL2 USP24 ATP1A1

7.94e-06190645e252e925600e6457fa6e362a55217f4cffa75cdb
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC9C1 IL1RAPL2 TRPV4 ATP1A1 TMC5

8.78e-0619464569bff17df4a760ccf081cf52ff04af02c14f448d
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC9C1 IL1RAPL2 TRPV4 ATP1A1 TMC5

8.78e-0619464504bfc555743f7d8821439d05ae442d15e9886c59
ToppCellLPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_3|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC9C1 IL1RAPL2 LRRTM3 MEGF10

5.81e-051466442ac9b487a7991fdc15444aeb93533030e09825bb
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell-Schwann_Cell_/_Neural-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MPZ IL1RAPL2 SLC5A7 MEGF10

7.15e-0515464430cb4bb297fa815adb829f3b5cafca56fcbcb810
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell-Schwann_Cell_/_Neural|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MPZ IL1RAPL2 SLC5A7 MEGF10

7.15e-05154644ade094e2947761a0a34daa8fcff3e9ea8437e4a5
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MPZ IL1RAPL2 SLC5A7 MEGF10

7.15e-0515464442bd8f88fd075a2d4edde394785decad88a2660a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MPZ IL1RAPL2 SLC5A7 MEGF10

7.15e-051546446425d9861148586466febd6eceae1b1f9b9a14c1
ToppCellLV-16._Neuronal|World / Chamber and Cluster_Paper

MPZ IL1RAPL2 SLC5A7 MEGF10

9.34e-051656446ed52cb756d21addf46c7f6c457458b01339fe04
ToppCellfacs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPCN2 IL1RAPL2 TRPV4 TMEM181

1.05e-04170644d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TSPAN15 MPZ ATP1A4 MEGF10

1.15e-04174644667035a11b68745fa8446d6c68214713be42710f
ToppCellPCW_13-14-Neuronal-Neuronal_postreplicative-neuro_NA|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MPZ IL1RAPL2 SLC5A7 MEGF10

1.22e-041776448c78f7de091f16e86e326a73c9f1429e0232821f
ToppCellILEUM-inflamed-(9)_Enteric_neurons|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MPZ IL1RAPL2 SLC5A7 MEGF10

1.25e-04178644d9142151819afb0dc22bfb32a9c9dba5f553067d
ToppCellILEUM-inflamed-(9)_Neuro_cell|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MPZ IL1RAPL2 SLC5A7 MEGF10

1.25e-04178644611504b0a9e6318b18fba83787b03f9245c82252
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TSPAN15 MPZ SLC5A7 MEGF10

1.31e-0418064438490017dd590e3fcfa7e88d8d15235d55f90cf1
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TSPAN15 MPZ SLC5A7 MEGF10

1.31e-04180644b294f9db1e2ff51c94cde64fae4c2b057c0030a1
ToppCellPCW_10-12-Neuronal-Neuronal_postreplicative|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MPZ IL1RAPL2 SLC5A7 MEGF10

1.33e-041816441aebb62ed4439db444ee9d30688212b86ee3d9ef
ToppCellPCW_10-12-Neuronal-Neuronal_postreplicative-neuro_NA|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MPZ IL1RAPL2 SLC5A7 MEGF10

1.33e-041816446aee2ddee4790250ef3b2ef0038bd9839925c995
ToppCellPCW_10-12-Neuronal|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MPZ IL1RAPL2 SLC5A7 MEGF10

1.33e-04181644381b553e2cae65ce6be100662a5f9f963353840c
ToppCellwk_15-18-Epithelial-PNS-Late_Schwann|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

TSPAN15 MPZ IL1RAPL2 MEGF10

1.36e-041826446462e0469224457e249d10e224082f727caa02d6
ToppCellControl-Epithelial_cells-Airway_mucous|Control / group, cell type (main and fine annotations)

TSPAN15 IL1RAPL2 TMC5 FER1L6

1.39e-0418364415d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCellPCW_13-14-Neuronal|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MPZ IL1RAPL2 SLC5A7 MEGF10

1.42e-0418464465cf3460125e3dbc34978957bc138a449f71f7df
ToppCellwk_08-11-Epithelial-PNS-COL20A1+_Schwann|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

TSPAN15 MPZ IL1RAPL2 MEGF10

1.45e-04185644abec2a49fe0f0fa4cba49347207a1ee317333657
ToppCellAnterior_Cingulate_gyrus_(CgG)|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

STAG3L1 STAG3L2 CD151 STAG3L3

1.48e-0418664432af3f211f9ad5d5c6b86b83325cfbf2f8466b56
ToppCellPCW_07-8.5-Neuronal|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MPZ IL1RAPL2 SLC5A7 MEGF10

1.48e-041866447a4bb42f3f6a27b463e48eafc587d9ab3386f2fb
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA1D SGSM1 USP24 ATP1A1

1.54e-04188644eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA1D SGSM1 USP24 ATP1A1

1.57e-04189644f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCellwk_08-11-Epithelial-PNS-Early_Schwann|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

TSPAN15 MPZ TPCN2 P2RY1

1.61e-041906448190674a48607984726974765aafbca116f437e0
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA1D SGSM1 USP24 ATP1A1

1.61e-04190644b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC9C1 IL1RAPL2 TRPV4 TMC5

1.64e-041916443e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCell3'-Child04-06-SmallIntestine-Neuronal|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TSPAN15 MPZ SLC5A7 SCARA3

1.77e-041956448d286622f86c844d1b06a106ee4a3f813eba05bb
ToppCell3'-Child04-06-SmallIntestine-Neuronal-Glial_mature|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TSPAN15 MPZ SLC5A7 SCARA3

1.77e-041956444193e58788e90c3d1049ef5cf9800a8c4d8ac354
ToppCell5'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TSPAN15 MPZ SLC5A7 MEGF10

1.77e-041956449fea1ddb68da83ca43dd8006c9e51295b1817f0e
ToppCell15-Airway-Epithelial-Epithelial|Airway / Age, Tissue, Lineage and Cell class

TSPAN15 MPZ SLC5A7 MEGF10

1.77e-0419564456356a9aeb67b50a74425be2cd9c50d31416c1b3
ToppCell3'-Child04-06-SmallIntestine-Neuronal-Glial_mature-Adult_Glia|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TSPAN15 MPZ SLC5A7 SCARA3

1.77e-04195644359b9d791e26844675c3c60cf69d8ab69c2cf400
ToppCell5'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TSPAN15 MPZ SLC5A7 MEGF10

1.81e-041966449afd0a7135028a446f06bb68f334e79b8f171b45
ToppCell10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma-muscle_stem_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

TSPAN15 CD151 LRRTM3 MEGF10

1.88e-0419864455e583321f60c95898d93cd0d2615c6692db52ec
ToppCell10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

TSPAN15 CD151 LRRTM3 MEGF10

1.92e-04199644e19b296d583f8bad3b66ee998a8153634d6fe09e
ToppCell10x3'2.3-week_17-19-Mesenchymal_myocytic|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

TSPAN15 CD151 LRRTM3 MEGF10

1.92e-04199644801887db51ac5dc5b068808ff75e3a46643398e9
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial-Astrocyte|GW12 / Sample Type, Dataset, Time_group, and Cell type.

TSPAN15 USP24 LRRTM3 SCARA3

1.95e-04200644b9bd6c4381c92bfc1bfff9aa778a62a41d08f1ef
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial|GW12 / Sample Type, Dataset, Time_group, and Cell type.

TSPAN15 USP24 LRRTM3 SCARA3

1.95e-04200644be1abe5bb1ce4e7dfec63af4ed0fc5b96bf77866
DrugCinnarizine

CACNA1C CACNA1D CACNA1F

1.68e-069633DB00568
DrugNimodipine

CACNA1C CACNA1D CACNA1F

1.68e-069633DB00393
DrugMibefradil

CACNA1C CACNA1D CACNA1F

3.28e-0611633DB01388
Drugmanidipine

CACNA1C CACNA1D CACNA1F TPCN2 HMGCR

6.60e-0695635CID000004008
DrugVerapamil

CACNA1C CACNA1D CACNA1F

1.10e-0516633DB00661
DrugCinildipine

CACNA1C CACNA1D CACNA1F TPCN2

1.75e-0556634CID000002752
Drugnilvadipine

CACNA1C CACNA1D CACNA1F TPCN2

2.31e-0560634CID000004494
Drugbepridil

CACNA1C CACNA1D CACNA1F TPCN2 ATP1A1

2.61e-05126635CID000002351
Druglercanidipine

CACNA1C CACNA1D CACNA1F TPCN2

2.80e-0563634CID000065866
Druggallopamil

CACNA1C CACNA1D CACNA1F TPCN2

3.58e-0567634CID000001234
DrugAC1L2AC7

CACNA1C CACNA1D CACNA1F TPCN2

4.02e-0569634CID000068733
DrugNSC-686960

CACNA1C CACNA1D

4.51e-054632CID000192816
DrugCAS 298-57-7

CACNA1C CACNA1D CACNA1F TPCN2

5.02e-0573634CID000002761
Drugethosuximide

CACNA1C CACNA1D CACNA1F TPCN2

5.30e-0574634CID000003291
Drugnisoldipine

CACNA1C CACNA1D CACNA1F TPCN2

6.51e-0578634CID000004499
Drugmethyl beta-aminocrotonate

CACNA1C CACNA1D

7.50e-055632CID000084253
DrugNilvadipine

CACNA1C CACNA1D

7.50e-055632DB06712
DrugNisoldipine

CACNA1C CACNA1D

7.50e-055632DB00401
Drugnemadipine-A

CACNA1C CACNA1D

7.50e-055632CID002856102
DrugB 874-67

CACNA1C CACNA1D

7.50e-055632CID000195466
DrugCNS 1145

CACNA1C CACNA1D CACNA1F

1.04e-0433633CID000190902
DrugIHC-64

CACNA1C CACNA1D CACNA1F

1.04e-0433633CID000162753
DrugCPU-23

CACNA1C CACNA1D

1.12e-046632CID003036051
Drugoleandrin

ATP1A1 CXCR1

1.12e-046632ctd:C021065
Drugisotetrandrine

CACNA1C CACNA1D CACNA1F SCARA3

1.52e-0497634CID000005422
DrugAmlodipine

CACNA1C CACNA1D

1.57e-047632DB00381
DrugIsradipine

CACNA1C CACNA1D

1.57e-047632DB00270
Drugnitrendipine

CACNA1C CACNA1D CACNA1F TPCN2

1.58e-0498634CID000004507
Drugisradipine

CACNA1C CACNA1D CACNA1F TPCN2

1.71e-04100634CID000003784
Drugloperamide

CACNA1C CACNA1D CACNA1F TPCN2

2.06e-04105634CID000003954
DrugNitrendipine

CACNA1C CACNA1D

2.09e-048632DB01054
Drug1,5-benzothiazepin-4(5H)-one

CACNA1C CACNA1D

2.09e-048632CID000358939
DrugNifedipine

CACNA1C CACNA1D

2.09e-048632DB01115
DrugSterols

HMGCR CXCR1

2.68e-049632ctd:D013261
DiseaseTimothy syndrome (implicated_via_orthology)

CACNA1C CACNA1D CACNA1F

3.19e-084603DOID:0060173 (implicated_via_orthology)
DiseaseDuchenne muscular dystrophy (implicated_via_orthology)

CACNA1C CACNA1D CACNA1F

5.44e-0536603DOID:11723 (implicated_via_orthology)
DiseaseConn Syndrome

CACNA1D ATP1A1

6.07e-056602C1384514
DiseaseHyperaldosteronism

CACNA1D ATP1A1

6.07e-056602C0020428
Diseasefamilial hemiplegic migraine (implicated_via_orthology)

ATP1A1 ATP1A4

8.48e-057602DOID:0060178 (implicated_via_orthology)
DiseaseHereditary Motor and Sensory Neuropathy Type I

MPZ TRPV4

1.13e-048602C0751036
DiseaseCharcot-Marie-Tooth Disease, Type Ib

MPZ TRPV4

1.13e-048602C0270912
DiseaseCharcot-Marie-Tooth Disease, Type Ia (disorder)

MPZ TRPV4

1.13e-048602C0270911
DiseaseRoussy-Levy Syndrome (disorder)

MPZ TRPV4

1.13e-048602C0205713
DiseaseCharcot-Marie-Tooth Disease

MPZ TRPV4

2.65e-0412602C0007959
Diseasenervous system disease (implicated_via_orthology)

ATP1A1 ATP1A4

2.65e-0412602DOID:863 (implicated_via_orthology)
DiseaseHereditary Motor and Sensory-Neuropathy Type II

MPZ TRPV4

3.13e-0413602C0270914
DiseaseCharcot-Marie-Tooth disease type 2

MPZ TRPV4

5.42e-0417602cv:C0270914
Diseaseresponse to tenofovir, creatinine clearance measurement

OR5T1 OR5M3 OR5M11

1.56e-03112603EFO_0007934, EFO_0009279
DiseaseMyopathy

HMGCR MEGF10

1.71e-0330602C0026848

Protein segments in the cluster

PeptideGeneStartEntry
LIVISYSFILKVVLR

OR56A4

216

Q8NGH8
VLLLALVIFYLTLII

CD83

146

Q01151
VLVVLFLLALFIIYR

MEGF10

866

Q96KG7
ALLVLFVIIIYAIIG

CACNA1F

241

O60840
ILVILVSYLFIIVAI

OR9Q2

211

Q8NGE9
LLFVLFLVVYLVTLL

OR5M11

26

Q96RB7
FLIIALSYVRIVTVI

OR6K3

226

Q8NGY3
RKSIYLVIIVLTVFA

P2RY1

256

P47900
FLLILLSYIRVLFAI

OR10A3

211

P58181
LTLILISYAFIVRAV

OR2B6

211

P58173
VVLFVVILIFYLITL

OR2J1

26

Q9GZK6
LLNFLILVVSYVIIL

OR4C12

206

Q96R67
DIIILTITRCIAILY

HMGCR

61

P04035
LLIFVYDEVRKLIIR

ATP1A1

996

P05023
TIVFLLLLISYGVIL

OR4A47

206

Q6IF82
ILFVVILIAYLLTLV

OR2W3

26

Q7Z3T1
LIVFVVVLIFYLLTL

OR2W6P

31

Q8NHA6
ILFSYVLILRTVLGI

OR51T1

216

Q8NGJ9
FLILIISYIFILVTV

OR4F6

211

Q8NGB9
FILLLVSYIVILVSV

OR4L1

211

Q8NH43
ILIISYVIILLNLRS

OR4S1

211

Q8NGB4
LTRLYVTILLTVLVF

MRGPRX3

211

Q96LB0
ILLFILFLIIYLLTV

OR2D3

41

Q8NGH3
LLLIIVSYTLIILSI

OR13C5

211

Q8NGS8
VIIISYLFILIAILR

OR5M3

211

Q8NGP4
VLFIVLLLIYVTSLI

OR5AK3P

26

Q8NH89
IILSYVFIVAAILRI

OR10H4

216

Q8NGA5
LLFIVLLGVYLVTVL

OR2D2

26

Q9H210
VESVLLGIVILLAYR

PLPPR2

21

Q96GM1
VTILIVLISYGFILL

OR5T1

221

Q8NG75
IALLVLFVIIIYAII

CACNA1C

271

Q13936
VVIIAYALVFLLSLL

CXCR1

41

P25024
ILLAIVVLYVALRRQ

CDH12

626

P55289
RLYFILLLIIFLLEI

CD151

91

P48509
RILYLFLALLLVAVA

SCARA3

56

Q6AZY7
LLHIALLVLFVIIIY

CACNA1D

271

Q01668
LLVLFVIIIYAIIGL

CACNA1D

276

Q01668
FLLILLSYIRVLFAI

OR10A6

211

Q8NH74
ASFLVIALSYIRIII

OR6K6

236

Q8NGW6
FVCIIISYLRILIAV

OR1L3

211

Q8NH93
LILFVIFLVLYVLTL

OR10J4

26

P0C629
LLLILVSYIRIISAI

OR10K1

211

Q8NGX5
LILVSYIRIVSAILR

OR1P1

226

Q8NH06
IVSLVILLLLIFISY

OR13D1

236

Q8NGV5
LLLLDVILIILSYVR

OR52E8

211

Q6IFG1
VILSYIFILQAVLLL

OR52K2

216

Q8NGK3
LIILIIFLVLFIYTL

FER1L6

1831

Q2WGJ9
EGLIAIIVFYLLILL

SLC5A7

6

Q9GZV3
LNIYLTLIVLRFLTL

SLC9C1

331

Q4G0N8
ALFLSVLVILLVIYV

LRRTM3

426

Q86VH5
LGAIFLLLVLLVVIY

IL1RAPL2

361

Q9NP60
LVSTLILISIAIVRY

NPY5R

126

Q15761
ILVASYVILLLVFLI

SMIM36

16

A0A1B0GVT2
YSVAVEAVRLLILIL

STAG3L1

101

P0CL83
LTRLYVTILLTVLVF

MRGPRX1

211

Q96LB2
LTRLYVTILLTVLVF

MRGPRX4

211

Q96LA9
SILIFVYDEIRKLLI

ATP1A4

1001

Q13733
FVVLVISIAILYLRF

TMEM181

501

Q9P2C4
FLGVLLTLLYITRVE

TSPAN15

246

O95858
YSVAVEAVRLLILIL

STAG3L2

101

P0CL84
FIALALVEVYRDIIL

SGSM1

1091

Q2NKQ1
LVIIERLLLLAERYV

USP24

921

Q9UPU5
YSVAVEAVRLLILIL

STAG3L3

101

P0CL85
VYVLLIRNIFLKISI

TMC5

691

Q6UXY8
IILLVTYIILTFVLL

TRPV4

696

Q9HBA0
VLLVLEISTLAVYRL

TPCN2

511

Q8NHX9
VVGTVLLLIRIILEY

VPS54

741

Q9P1Q0
LGVVLLLLLLFYVVR

MPZ

166

P25189