Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix structural constituent

COL4A4 COL9A2 ACAN LAMA5 SSPOP MUC5AC

1.02e-05188536GO:0005201
GeneOntologyMolecularFunctionalkaline phosphatase activity

CILP2 ALPG

1.03e-046532GO:0004035
GeneOntologyBiologicalProcessmolting cycle process

CELSR1 FOXQ1 LRIG1 LGR4 LAMA5

1.78e-05126535GO:0022404
GeneOntologyBiologicalProcesshair cycle process

CELSR1 FOXQ1 LRIG1 LGR4 LAMA5

1.78e-05126535GO:0022405
GeneOntologyBiologicalProcessmolting cycle

CELSR1 FOXQ1 LRIG1 LGR4 LAMA5

4.12e-05150535GO:0042303
GeneOntologyBiologicalProcesshair cycle

CELSR1 FOXQ1 LRIG1 LGR4 LAMA5

4.12e-05150535GO:0042633
GeneOntologyBiologicalProcessextracellular matrix organization

COL4A4 COL9A2 ADAMTSL1 FKRP ACAN ADAMTS20 MMP3

4.82e-05377537GO:0030198
GeneOntologyBiologicalProcessextracellular structure organization

COL4A4 COL9A2 ADAMTSL1 FKRP ACAN ADAMTS20 MMP3

4.90e-05378537GO:0043062
GeneOntologyBiologicalProcessexternal encapsulating structure organization

COL4A4 COL9A2 ADAMTSL1 FKRP ACAN ADAMTS20 MMP3

4.98e-05379537GO:0045229
GeneOntologyBiologicalProcesshair follicle development

CELSR1 FOXQ1 LGR4 LAMA5

2.81e-04123534GO:0001942
GeneOntologyBiologicalProcessanimal organ morphogenesis

TGFB3 CELSR1 LRIG1 PTF1A FKRP ACAN LGR4 LAMA5 LTBP3 AHDC1 NOTCH2

3.19e-0412695311GO:0009887
GeneOntologyCellularComponentextracellular matrix

TGFB3 COL4A4 COL9A2 ADAMTSL1 LRIG1 CD248 ACAN LAMA5 ADAMTS20 LTBP3 MMP3 SSPOP MUC5AC

5.24e-096565213GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

TGFB3 COL4A4 COL9A2 ADAMTSL1 LRIG1 CD248 ACAN LAMA5 ADAMTS20 LTBP3 MMP3 SSPOP MUC5AC

5.43e-096585213GO:0030312
GeneOntologyCellularComponentcollagen-containing extracellular matrix

TGFB3 COL4A4 COL9A2 ADAMTSL1 ACAN LAMA5 ADAMTS20 LTBP3 SSPOP

5.64e-06530529GO:0062023
GeneOntologyCellularComponentsynapse-associated extracellular matrix

ACAN LAMA5

4.65e-0413522GO:0099535
MousePhenoabnormal pilosebaceous unit morphology

CELSR1 FOXQ1 LRIG1 LGR4 LAMA5 ADAMTS20

2.01e-05205396MP:0030572
MousePhenoabnormal hair follicle morphology

CELSR1 LRIG1 LGR4 LAMA5 ADAMTS20

5.36e-05148395MP:0000377
MousePhenocranial bossing

FKRP LTBP3

7.54e-055392MP:0030263
MousePhenoimpaired branching involved in ureteric bud morphogenesis

LGR4 LAMA5 NOTCH2

1.99e-0441393MP:0004936
MousePhenoabnormal renal glomerular capsule morphology

COL4A4 LGR4 LAMA5 NOTCH2

2.17e-04107394MP:0002828
MousePhenoincreased kidney apoptosis

LGR4 LAMA5 NOTCH2

2.29e-0443393MP:0011368
MousePhenoabnormal branching involved in ureteric bud morphogenesis

LGR4 LAMA5 NOTCH2

2.63e-0445393MP:0010981
MousePhenosmall lung

TGFB3 CELSR1 ACAN LAMA5

2.86e-04115394MP:0003641
MousePhenoabnormal brain development

SLC17A5 CELSR1 FOXQ1 ZMYND10 PTF1A FKRP LAMA5 ADAMTS20

3.15e-04638398MP:0000913
MousePhenoshort basicranium

ACAN LTBP3

3.37e-0410392MP:0030420
MousePhenoabnormal somatic nervous system morphology

SLC17A5 CELSR1 PLAA SHC2 PTF1A FKRP ACAN LPP LGR4 MMP3

3.84e-0410253910MP:0002752
MousePhenoabnormal kidney apoptosis

LGR4 LAMA5 NOTCH2

4.27e-0453393MP:0011367
MousePhenopulmonary hypoplasia

TGFB3 CELSR1 ACAN

4.51e-0454393MP:0001178
MousePhenoabnormal epidermal-dermal junction morphology

LAMA5 AHDC1

4.92e-0412392MP:0011159
MousePhenoabnormal ureteric bud morphology

LGR4 LAMA5 NOTCH2

5.29e-0457393MP:0006032
DomainTSP_1

CILP2 ADAMTSL1 ADAMTS20 SSPOP

2.61e-0563514PF00090
DomainTSP1

CILP2 ADAMTSL1 ADAMTS20 SSPOP

2.95e-0565514SM00209
DomainTSP1_rpt

CILP2 ADAMTSL1 ADAMTS20 SSPOP

2.95e-0565514IPR000884
DomainTSP1

CILP2 ADAMTSL1 ADAMTS20 SSPOP

2.95e-0565514PS50092
DomainGrowth_fac_rcpt_

CELSR1 CD248 LAMA5 LTBP3 NOTCH2

6.57e-05156515IPR009030
DomainEGF_1

CELSR1 CD248 LAMA5 LTBP3 SSPOP NOTCH2

6.57e-05255516PS00022
DomainEGF_2

CELSR1 CD248 LAMA5 LTBP3 SSPOP NOTCH2

8.13e-05265516PS01186
DomainWxxW_domain

CILP2 MUC5AC

1.09e-046512IPR025155
DomainMucin2_WxxW

CILP2 MUC5AC

1.09e-046512PF13330
DomainEGF-type_Asp/Asn_hydroxyl_site

CELSR1 CD248 LTBP3 NOTCH2

1.99e-04106514IPR000152
DomainEGF_CA

CELSR1 CD248 LTBP3 NOTCH2

3.42e-04122514SM00179
DomainEGF-like_Ca-bd_dom

CELSR1 CD248 LTBP3 NOTCH2

3.63e-04124514IPR001881
DomainEGF_3

CELSR1 CD248 LTBP3 SSPOP NOTCH2

4.43e-04235515PS50026
DomainEGF

CELSR1 CD248 LAMA5 LTBP3 NOTCH2

4.43e-04235515SM00181
DomainTIL

SSPOP MUC5AC

4.74e-0412512PF01826
DomainC8

SSPOP MUC5AC

4.74e-0412512PF08742
DomainUnchr_dom_Cys-rich

SSPOP MUC5AC

5.59e-0413512IPR014853
DomainC8

SSPOP MUC5AC

5.59e-0413512SM00832
DomainEGF-like_dom

CELSR1 CD248 LAMA5 LTBP3 NOTCH2

5.76e-04249515IPR000742
DomainTIL_dom

SSPOP MUC5AC

6.51e-0414512IPR002919
DomainEGF-like_CS

CELSR1 CD248 LAMA5 LTBP3 NOTCH2

7.13e-04261515IPR013032
DomainVWD

SSPOP MUC5AC

8.56e-0416512SM00216
DomainVWF_type-D

SSPOP MUC5AC

8.56e-0416512IPR001846
DomainVWFD

SSPOP MUC5AC

8.56e-0416512PS51233
DomainVWD

SSPOP MUC5AC

8.56e-0416512PF00094
DomainCTCK_1

SSPOP MUC5AC

1.09e-0318512PS01185
DomainVWC_out

SSPOP MUC5AC

1.21e-0319512SM00215
Domainzf-MYND

ZMYND10 TDRD1

1.49e-0321512PF01753
DomainZnf_MYND

ZMYND10 TDRD1

1.63e-0322512IPR002893
DomainZF_MYND_1

ZMYND10 TDRD1

1.63e-0322512PS01360
DomainZF_MYND_2

ZMYND10 TDRD1

1.63e-0322512PS50865
DomainEGF_CA

CD248 LTBP3 NOTCH2

1.67e-0386513PF07645
DomainPeptidase_M12B_ADAM-TS

ADAMTSL1 ADAMTS20

1.94e-0324512IPR013273
DomainCys_knot_C

SSPOP MUC5AC

2.11e-0325512IPR006207
DomainCTCK_2

SSPOP MUC5AC

2.11e-0325512PS01225
DomainEGF_Ca-bd_CS

CD248 LTBP3 NOTCH2

2.36e-0397513IPR018097
DomainEGF_CA

CD248 LTBP3 NOTCH2

2.50e-0399513PS01187
DomainASX_HYDROXYL

CELSR1 LTBP3 NOTCH2

2.57e-03100513PS00010
DomainhEGF

LTBP3 NOTCH2

2.64e-0328512PF12661
DomainEGF_LAM_2

CELSR1 LAMA5

3.03e-0330512PS50027
DomainEGF_LAM_1

CELSR1 LAMA5

3.03e-0330512PS01248
DomainLaminin_EGF

CELSR1 LAMA5

4.11e-0335512PF00053
DomainEGF_Lam

CELSR1 LAMA5

4.11e-0335512SM00180
DomainVWFC_1

SSPOP MUC5AC

4.34e-0336512PS01208
DomainVWC

SSPOP MUC5AC

4.83e-0338512SM00214
DomainVWFC_2

SSPOP MUC5AC

4.83e-0338512PS50184
DomainLAM_G_DOMAIN

CELSR1 LAMA5

4.83e-0338512PS50025
DomainLaminin_EGF

CELSR1 LAMA5

4.83e-0338512IPR002049
DomainEGF

CELSR1 CD248 NOTCH2

4.93e-03126513PF00008
DomainLaminin_G_2

CELSR1 LAMA5

5.34e-0340512PF02210
DomainVWF_dom

SSPOP MUC5AC

5.87e-0342512IPR001007
DomainLamG

CELSR1 LAMA5

6.43e-0344512SM00282
DomainLRRNT

LRIG1 LGR4

9.22e-0353512PF01462
Domain-

ZNF668 ZNF628 FIZ1 ZNF837 ZFP92 ZNF580

1.01e-026795163.30.160.60
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTSL1 ADAMTS20 SSPOP MUC5AC NOTCH2

8.70e-0768375M27303
PathwayREACTOME_ECM_PROTEOGLYCANS

TGFB3 COL4A4 COL9A2 ACAN LAMA5

1.52e-0676375M27219
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTSL1 ACAN ADAMTS20 SSPOP MUC5AC NOTCH2

1.76e-06143376M27275
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

TGFB3 COL4A4 COL9A2 ACAN LAMA5 LTBP3 MMP3

1.10e-05300377M610
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

COL4A4 COL9A2 ACAN LAMA5 MMP3

3.04e-05140375M587
PathwayREACTOME_DISEASES_OF_METABOLISM

ADAMTSL1 ACAN ADAMTS20 SSPOP MUC5AC NOTCH2

4.29e-05250376M27554
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

TGFB3 COL4A4 COL9A2 ACAN LTBP3 MMP3

5.12e-05258376MM14572
PathwayWP_HAIR_FOLLICLE_DEVELOPMENT_CYTODIFFERENTIATION_STAGE_3_OF_3

FOXQ1 LRIG1 ADAMTS20 NOTCH2

7.65e-0587374M39465
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTSL1 ADAMTS20 SSPOP

1.43e-0439373M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTSL1 ADAMTS20 SSPOP

1.43e-0439373MM15165
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTSL1 ADAMTS20 SSPOP MUC5AC

1.84e-04109374MM15164
PathwayKEGG_MEDICUS_REFERENCE_PLASMIN_MEDIATED_ACTIVATION_OF_LATENT_TGF_BETA

TGFB3 LTBP3

1.86e-048372M47850
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTSL1 ADAMTS20 SSPOP MUC5AC

1.97e-04111374M27416
PathwayPID_SYNDECAN_1_PATHWAY

COL4A4 COL9A2 LAMA5

2.34e-0446373M198
PathwayREACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES

COL4A4 COL9A2 MMP3

3.00e-0450373MM14796
PathwayREACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES

COL4A4 COL9A2 MMP3

5.39e-0461373M27103
PathwayREACTOME_COLLAGEN_DEGRADATION

COL4A4 COL9A2 MMP3

6.21e-0464373M26953
PathwayWP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER

TGFB3 COL4A4 FOXQ1 NOTCH2

8.07e-04161374M39770
PathwayREACTOME_COLLAGEN_FORMATION

COL4A4 COL9A2 MMP3

1.03e-0376373MM14573
PathwayREACTOME_NCAM1_INTERACTIONS

COL4A4 COL9A2

1.24e-0320372MM15061
PathwayREACTOME_COLLAGEN_FORMATION

COL4A4 COL9A2 MMP3

1.67e-0390373M631
Pubmed

ROCK inhibition enhances aggrecan deposition and suppresses matrix metalloproteinase-3 production in human articular chondrocytes.

ACAN MMP3

2.28e-06253224111521
Pubmed

Latent transforming growth factor β binding protein 3 controls adipogenesis.

TGFB3 LTBP3

2.28e-06253235933071
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

CILP2 ADAMTSL1 ADAMTS20 SSPOP

5.39e-067553420637190
Pubmed

Association of CILP, COL9A2 and MMP3 Gene Polymorphisms with Lumbar Disc Degeneration in an Indian Population.

COL9A2 MMP3

6.83e-06353230288688
Pubmed

Function assignment to conserved residues in mammalian alkaline phosphatases.

PLAA ALPG

6.83e-06353211937510
Pubmed

TGFβ3, MSX1, and MMP3 as Candidates for NSCL±P in an Indian Population.

TGFB3 MMP3

6.83e-06353229738289
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

COL4A4 COL9A2 ADAMTSL1 LAMA5 SSPOP

7.19e-0617553528071719
Pubmed

Associations of 25 structural, degradative, and inflammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing.

COL9A2 ACAN MMP3

7.51e-062553319180518
Pubmed

Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development.

TGFB3 MUC5AC NOTCH2

9.52e-062753321791528
Pubmed

Chondromodulin I is dispensable during enchondral ossification and eye development.

TGFB3 COL9A2 ACAN

9.52e-062753312192060
Pubmed

Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion.

TGFB3 LTBP3

1.36e-05453212062452
Pubmed

Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate.

LRIG1 LAMA5 ADAMTS20

1.77e-053353318480165
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ADAMTSL1 LAMA5 MAPKBP1 SSPOP

2.05e-051055349628581
Pubmed

Assessment of the association between genetic polymorphisms in transforming growth factor beta, and its binding protein (LTBP), and the presence, and expansion, of Abdominal Aortic Aneurysm.

TGFB3 LTBP3

2.27e-05553219897194
Pubmed

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma.

PTF1A NOTCH2

2.27e-05553220624967
Pubmed

Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.

TGFB3 LTBP3 MMP3

2.30e-053653320587546
Pubmed

The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3.

TGFB3 LTBP3

3.40e-05653212358597
Pubmed

Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan.

ACAN MMP3

3.40e-0565327998967
Pubmed

ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors.

ACAN MMP3

3.40e-05653212054629
Pubmed

Circulating levels of interleukin-6, vascular endothelial growth factor, YKL-40, matrix metalloproteinase-3, and total aggrecan in spondyloarthritis patients during 3 years of treatment with TNFα inhibitors.

ACAN MMP3

3.40e-05653220640910
Pubmed

Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain.

ACAN MMP3

4.76e-0575328216228
Pubmed

Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP).

ACAN MMP3

4.76e-05753210922468
Pubmed

Mutation in type II collagen gene disturbs spinal development and gene expression patterns in transgenic Del1 mice.

COL9A2 ACAN

4.76e-0575329426396
Pubmed

MYC in pancreatic cancer: novel mechanistic insights and their translation into therapeutic strategies.

PTF1A NOTCH2

4.76e-05753226119937
Pubmed

Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta.

TGFB3 LTBP3

4.76e-05753210930463
Pubmed

Genetic factors are associated with modic changes in endplates of lumbar vertebral bodies.

COL9A2 MMP3

6.34e-05853218469698
Pubmed

Occupational and genetic risk factors associated with intervertebral disc disease.

COL9A2 MMP3

6.34e-05853217471097
Pubmed

Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome.

COL4A4 LAMA5

8.15e-05953210880400
Pubmed

Targeted disruption of the homeobox transcription factor Bapx1 results in lethal skeletal dysplasia with asplenia and gastroduodenal malformation.

COL9A2 ACAN

1.02e-041053210886375
Pubmed

Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development.

TGFB3 NOTCH2

1.24e-041153216607638
Pubmed

TGF-beta3-induced palatogenesis requires matrix metalloproteinases.

TGFB3 MMP3

1.24e-041153211359935
Pubmed

Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin.

COL4A4 LAMA5

1.24e-041153211435469
Pubmed

Defective lymphatic valve development and chylothorax in mice with a lymphatic-specific deletion of Connexin43.

LAMA5 GJC2

1.24e-041153227899284
Pubmed

Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.

LRIG1 LGR4

1.24e-041153220223988
Pubmed

Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells.

FOXQ1 MUC5AC

1.49e-041253218558092
Pubmed

Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP/CHSY1 Axis.

ACAN MMP3

1.49e-041253236047655
Pubmed

Basement membrane fragility underlies embryonic lethality in fukutin-null mice.

COL4A4 FKRP

1.49e-041253215837576
Pubmed

Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development.

CELSR1 LAMA5

1.76e-041353227789626
Pubmed

Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane.

COL4A4 LAMA5

1.76e-041353212682087
Pubmed

Fukutin-related protein alters the deposition of laminin in the eye and brain.

FKRP LAMA5

1.76e-041353221900571
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

LTBP3 SSPOP MUC5AC

1.77e-047153333541421
Pubmed

A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc development.

TGFB3 ACAN

2.05e-041453228011632
Pubmed

Long form of latent TGF-beta binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling.

TGFB3 LTBP3

2.36e-041553217804598
Pubmed

Collagen II is essential for the removal of the notochord and the formation of intervertebral discs.

COL9A2 ACAN

2.36e-04155329832566
Pubmed

Perlecan maintains the integrity of cartilage and some basement membranes.

COL9A2 ACAN

2.36e-041553210579729
Pubmed

Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.

CELSR1 SSPOP

2.36e-041553220473291
Pubmed

Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane.

COL4A4 LAMA5

2.36e-041553210625553
Pubmed

Localization of basement membrane-associated protein isoforms during development of the ocular surface of mouse eye.

COL4A4 LAMA5

2.36e-04155329264260
Pubmed

Muscleblind-like 1 is required for normal heart valve development in vivo.

TGFB3 ACAN

2.36e-041553226472242
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

CELSR1 INTS5 ZNF628 LAMA5 LTBP3 MAPKBP1 AHDC1 NOTCH2

2.52e-04110553835748872
Pubmed

Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation.

TGFB3 COL9A2 LAMA5

2.62e-048153339217171
Pubmed

GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling.

PTF1A MUC5AC

2.70e-041653226932670
Pubmed

Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.

PTF1A NOTCH2

2.70e-041653210868931
Pubmed

Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling.

LRIG1 LAMA5

2.70e-041653235132078
Pubmed

Conditional ablation of Notch signaling in pancreatic development.

PTF1A NOTCH2

2.70e-041653218635610
Pubmed

Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice.

LAMA5 GJC2

2.70e-041653226953188
Pubmed

Notch signalling controls pancreatic cell differentiation.

PTF1A NOTCH2

3.05e-041753210476967
Pubmed

Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3.

PTF1A NOTCH2

3.43e-041853210825208
Pubmed

Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9.

TGFB3 NOTCH2

3.43e-041853219403103
Pubmed

Primary cilia maintain corneal epithelial homeostasis by regulation of the Notch signaling pathway.

MUC5AC NOTCH2

3.83e-041953227122169
Pubmed

RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development.

ACAN NOTCH2

3.83e-041953220335360
Pubmed

A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation.

PTF1A NOTCH2

3.83e-041953222675211
Pubmed

Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development.

ACAN MMP3

4.25e-042053220495570
Pubmed

Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci.

TGFB3 FOXQ1

4.70e-04215321970330
Pubmed

A developmental lineage-based gene co-expression network for mouse pancreatic β-cells reveals a role for Zfp800 in pancreas development.

PTF1A ZFP92

4.70e-042153233653874
Pubmed

Loss of GATA4 causes ectopic pancreas in the stomach.

PTF1A MUC5AC

4.70e-042153231875961
Pubmed

PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα.

COL4A4 LAMA5

4.70e-042153227856617
Pubmed

FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development.

PTF1A NOTCH2

4.70e-042153214651921
Pubmed

E3 ubiquitin ligase FBXW7 balances airway cell fates.

MUC5AC NOTCH2

5.16e-042253234998785
Pubmed

Maternal immune activation leads to defective brain-blood vessels and intracerebral hemorrhages in male offspring.

TGFB3 CD248

5.16e-042253236314682
Pubmed

Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice.

LGR4 ALPG

5.65e-042353224680895
Pubmed

Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression.

PTF1A NOTCH2

5.65e-042353219805515
Pubmed

Essential role of the zinc finger transcription factor Casz1 for mammalian cardiac morphogenesis and development.

TGFB3 ACAN

5.65e-042353225190801
Pubmed

Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion.

TGFB3 LAMA5

5.65e-042353229981310
Pubmed

Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors.

PTF1A NOTCH2

6.16e-042453232059775
Pubmed

Loss of Krox20 results in aortic valve regurgitation and impaired transcriptional activation of fibrillar collagen genes.

ACAN MMP3

6.16e-042453225344368
Pubmed

Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis.

ACAN ADAMTS20

6.68e-042553229475039
Pubmed

Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins.

COL4A4 LAMA5

7.23e-042653224742657
Pubmed

Adamts18 modulates the development of the aortic arch and common carotid artery.

ACAN LAMA5

7.23e-042653234189436
Pubmed

Signalling codes for the maintenance and lineage commitment of embryonic gastric epithelial progenitors.

MUC5AC NOTCH2

7.80e-042753232878924
Pubmed

Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.

TGFB3 ACAN

7.80e-042753235894043
Pubmed

Excess neuropeptides in lung signal through endothelial cells to impair gas exchange.

MUC5AC NOTCH2

7.80e-042753235303432
Pubmed

Cdc42-mediated tubulogenesis controls cell specification.

PTF1A NOTCH2

8.40e-042853219914171
Pubmed

Notch signaling in stomach epithelial stem cell homeostasis.

MUC5AC NOTCH2

9.01e-042953221402740
Pubmed

MFng is dispensable for mouse pancreas development and function.

PTF1A NOTCH2

9.64e-043053219223466
Pubmed

Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos.

METRN NOTCH2

9.64e-043053238636517
Pubmed

ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation.

LAMA5 NOTCH2

1.03e-033153222274697
Pubmed

Large-scale identification of genes implicated in kidney glomerulus development and function.

COL4A4 LAMA5

1.24e-033453216498405
Pubmed

Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier.

TGFB3 CD248

1.24e-033453226120030
Pubmed

Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity.

PTF1A MUC5AC

1.39e-033653227736991
Pubmed

Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development.

CELSR1 MUC5AC

1.39e-033653228859094
Pubmed

Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate.

TGFB3 MMP3

1.39e-033653220672350
Pubmed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.

ACAN LAMA5 LTBP3

1.46e-0314653327068509
Pubmed

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.

LRIG1 LPP

1.47e-033753222797727
InteractionEDN3 interactions

CILP2 CELSR1 METRN LAMA5 NOTCH2

7.77e-06108515int:EDN3
InteractionOIT3 interactions

CILP2 CELSR1 METRN LAMA5

2.20e-0565514int:OIT3
InteractionFBLN2 interactions

COL4A4 ZNF628 ACAN LAMA5

2.33e-0566514int:FBLN2
InteractionMUC5AC interactions

IGHA2 RASL11B MUC5AC

2.61e-0523513int:MUC5AC
InteractionSIRPD interactions

CILP2 CELSR1 METRN LAMA5

6.63e-0586514int:SIRPD
InteractionPRG2 interactions

CILP2 CELSR1 METRN LAMA5 LTBP3 NOTCH2

8.01e-05285516int:PRG2
InteractionBCAN interactions

CILP2 LAMA5 MMP3

1.03e-0436513int:BCAN
Cytoband19q13.42

ZNF628 FIZ1 ZNF580

4.18e-0412553319q13.42
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

CD248 ACAN

4.27e-03414321298
GeneFamilyCollagens

COL4A4 COL9A2

5.35e-0346432490
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF668 ZNF628 FIZ1 ZNF837 ZFP92 ZNF580

6.69e-0371843628
CoexpressionNABA_MATRISOME

TGFB3 COL4A4 COL9A2 CILP2 ADAMTSL1 ACAN LAMA5 ADAMTS20 LTBP3 MMP3 SSPOP MUC5AC SERPINA9

7.51e-0810085313MM17056
CoexpressionNABA_MATRISOME

TGFB3 COL4A4 COL9A2 CILP2 ADAMTSL1 ACAN LAMA5 ADAMTS20 LTBP3 MMP3 SSPOP MUC5AC SERPINA9

9.22e-0810265313M5889
CoexpressionNABA_CORE_MATRISOME

COL4A4 COL9A2 CILP2 ACAN LAMA5 LTBP3 SSPOP

1.17e-06270537MM17057
CoexpressionNABA_CORE_MATRISOME

COL4A4 COL9A2 CILP2 ACAN LAMA5 LTBP3 SSPOP

1.32e-06275537M5884
CoexpressionGSE22443_IL2_VS_IL12_TREATED_ACT_CD8_TCELL_UP

SHC2 VPS8 OTUD7A GJC2 TMEM102

5.12e-05199535M8223
CoexpressionLAKE_ADULT_KIDNEY_C21_COLLECTING_DUCT_INTERCALATED_CELLS_TYPE_B

COL4A4 ADAMTSL1 LPP LGR4

5.68e-05103534M39240
ToppCelldroplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TGFB3 ADAMTSL1 SHC2 CD248 RASL11B MMP3

1.12e-07193536fe9720185929ef849edd1b8eb4854306b392e5a2
ToppCellfacs-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 CD248 RASL11B GJC2 MMP3

2.45e-06181535269b39ac65790061d54eab47a8eeb024403f0348
ToppCellfacs-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 CD248 RASL11B GJC2 MMP3

2.45e-06181535cd4f744b6b64ba6c22ec07afd1d3058a2546909d
ToppCellfacs-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 CD248 RASL11B GJC2 MMP3

2.45e-06181535c8395ae872aa80b3ae1ab7c53e57b3ca15aeb0e2
ToppCellPND01-03-samps-Mesenchymal-Myofibroblast|PND01-03-samps / Age Group, Lineage, Cell class and subclass

TGFB3 FOXQ1 LRIG1 CD248 LGR4

2.51e-06182535812dac35b9aa05be48258082e007f6c00e7b4dd8
ToppCelldroplet-Kidney-nan-21m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 SHC2 CD248 GJC2 MMP3

2.65e-061845353bffadb0cb2e0d825bdb6cfc5d23f5436cbc3efd
ToppCelldroplet-Kidney-nan-21m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 SHC2 CD248 GJC2 MMP3

2.72e-061855359954fc85b183c1cc45c3c24e3dadc7984ee6f649
ToppCelldroplet-Kidney-nan-21m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 SHC2 CD248 GJC2 MMP3

2.72e-0618553533cc0e9d8b54cb7408b51235f2a70e044ebae04d
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB3 LRIG1 CD248 LPP LAMA5

2.72e-0618553538486b69c48dc5e1c4e1488208fa8954a973eccb
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB3 LRIG1 CD248 LPP LAMA5

2.72e-061855353c28b5ceba3cfdb6f7e32d5b42e03b6a81a7a658
ToppCellfacs-Aorta-Heart-3m-Mesenchymal-leukocyte|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL9A2 CILP2 CELSR1 ACAN TMEM102

3.18e-06191535116fba9badea093e11f370996247cca0e4c02e8f
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB3 ADAMTSL1 CD248 LTBP3 MMP3

3.35e-06193535858a186804b36d45957238d3d3eed2768b961641
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB3 ADAMTSL1 CD248 LTBP3 MMP3

3.35e-061935357865e7ec0a288249540d4cba94ae01c93e1b617c
ToppCelldroplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TGFB3 ADAMTSL1 CD248 RASL11B MMP3

3.43e-06194535ca1f24070424b44b7a442e4fca761ebfbe24b063
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB3 ADAMTSL1 CD248 LPP LAMA5

3.43e-06194535bf34737ae2dc218f890fbb9201c308b324415749
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB3 ADAMTSL1 CD248 LPP LAMA5

3.43e-061945354ebed7a6731b88c8359860072cbeba355a7e90ac
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL9A2 FOXQ1 CD248 RASL11B GJC2

3.52e-06195535b0d408f8bc1701a87596ed55efcd90749fee33e6
ToppCell15-Airway-Mesenchymal-Cartilage|Airway / Age, Tissue, Lineage and Cell class

COL9A2 CILP2 ACAN RASL11B C2orf72

3.52e-06195535414f60bc0f0d0ecb5137bcd617fae91f0c15038a
ToppCellFibroblast-B_(Myofibroblast)|World / shred on cell class and cell subclass (v4)

TGFB3 FOXQ1 CD248 LPP RASL11B

3.52e-06195535a8d6416518f226e1ec2d6bdc9d4b90cef5cb1365
ToppCellP07-Mesenchymal-myocytic_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TGFB3 FOXQ1 CD248 LPP RASL11B

3.70e-06197535378299fe2ec6ed2fc858febb78ff1ac0898e457d
ToppCellNon-neuronal-Non-dividing-Radial_Glia-tRG-25|World / Primary Cells by Cluster

CELSR1 LRIG1 LPP NOTCH2 C2orf72

3.70e-061975359d4ffa3680f92c91d0a081f9a8ec5ebfec6bdcf6
ToppCellNon-neuronal-Non-dividing-Radial_Glia-tRG|World / Primary Cells by Cluster

CELSR1 LRIG1 LPP NOTCH2 C2orf72

3.70e-0619753561749ccafeb938c310cff1de5ff924a1c794325a
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TGFB3 FOXQ1 CD248 LPP RASL11B

3.79e-061985350993d6895c0e4f360998ce35abea4ec3dd13e048
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TGFB3 FOXQ1 CD248 LPP RASL11B

3.79e-06198535a699b365d3b6149f13f02b2e2ae9b6fdce761848
ToppCellfacs-Trachea-nan-3m-Mesenchymal-chondrocyte|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB3 COL9A2 CILP2 ACAN LTBP3

3.79e-0619853571e847e8c24744d6df4a960348ad2ecf310373b4
ToppCelldroplet-Trachea|droplet / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB3 COL9A2 CILP2 ACAN LTBP3

3.89e-061995351c7d30765ddb2291967da5d15664c6238c680c1d
ToppCelldroplet-Trachea|droplet / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TGFB3 COL9A2 CILP2 ACAN LTBP3

3.89e-06199535b9038a1ccf3ef3123e2e39afbe6213c363437443
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TGFB3 COL9A2 CILP2 ACAN LTBP3

3.98e-06200535be527df943a8cedc6452ecef3cafc282db34ceb8
ToppCelldroplet-Trachea-nan-3m-Mesenchymal-fibroblast|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB3 COL9A2 CILP2 ACAN LTBP3

3.98e-06200535c935caef2988f165e96d8f1ef99ae8963ab9377f
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l28|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TGFB3 COL9A2 CILP2 ACAN LTBP3

3.98e-06200535d254f6634895486f81d7a8b6f006fbc2679eaa5b
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TGFB3 COL9A2 CILP2 ACAN LTBP3

3.98e-062005358e41a484038216f0c2ad258fd46c0e702a4bb8bf
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTF1A OTUD7A TDRD1 SSPOP

2.34e-051405347ca49bd7ba9381e75c10f888775df17e5d46804d
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTF1A OTUD7A TDRD1 SSPOP

2.34e-051405341a31bc33d5723b9bc528cc0047ca5f4c80531c7a
ToppCellE18.5-samps-Mesenchymal-Myofibroblast-MyoFB-1|E18.5-samps / Age Group, Lineage, Cell class and subclass

CILP2 ZMYND10 MMP3 SERPINA9

2.68e-05145534ac41c6c02b7d78162b86222983688f54d04ac47d
ToppCell368C-Fibroblasts-Fibroblast-F-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

COL4A4 ADAMTSL1 OTUD7A TMEM102

2.98e-051495349286bc56ff2e245630537a0bda5f1a1e17be863a
ToppCell368C-Fibroblasts-Fibroblast-F|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

COL4A4 ADAMTSL1 OTUD7A TMEM102

2.98e-05149534f53151d9e5e724a61be0ee6a8c740d1990f28d5f
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-Lgr5-_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR1 ZMYND10 PTF1A LAMA5

3.48e-05155534f3489a548a2c0cc2d9117ff85865c6089ea0835d
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-epithelial_cell_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR1 ZMYND10 PTF1A LAMA5

3.48e-051555340e24e767a3895d31d34cabeaca0354aadae34e44
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte-Chondrocyte_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL9A2 ACAN LGR4 AHDC1

4.55e-0516653437794a84601a2a949d579663d4a4bb8bc8fb5923
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL9A2 ACAN LGR4 AHDC1

4.55e-0516653481c546c6d847e49e662b81e71992ca0f7a99e890
ToppCellwk_20-22-Mesenchymal-Chondrocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

COL9A2 CILP2 ACAN RASL11B

5.10e-05171534d2938639e9a7c349e5a6ec61724222f9d127c89f
ToppCellBronchial_Biopsy-Endothelial-Lymphatic|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

ADAMTSL1 SHC2 GJC2 SSPOP

5.22e-05172534c41f5a66781bbf63afce7ca5d118cc6d8e0fe0bc
ToppCelldroplet-Heart-HEART-1m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR1 ADAMTSL1 VPS8 GJC2

5.34e-051735349dc7746a84f0e268a7c061e1bbcd5e31903034dc
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL9A2 CILP2 ACAN ADAMTS20

5.58e-05175534f1394aacc8a94ca555dd19aaed5a18da99c6bf40
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL9A2 CILP2 ACAN ADAMTS20

5.58e-051755347bf1194d93fbe2dbf9d953e0a32b2a6d88251ed1
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SHC2 METRN LRIG1 C2orf72

5.58e-05175534e99e145a152f534b75267ec492a252a0b814b4f8
ToppCellsevere-B_memory|World / disease stage, cell group and cell class

COL4A4 IGHA2 LGR4 LAMA5

5.71e-051765344e5c6b1aa5ffd13593a6bcd1e1253c1737c5c2b4
ToppCellP28-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TGFB3 CELSR1 ADAMTSL1 GJC2

5.83e-05177534e96a7e4544710aaab8bd2800ecff9667880a8bf4
ToppCellP28-Endothelial-lymphatic_endothelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TGFB3 CELSR1 ADAMTSL1 GJC2

5.83e-051775346e330aa3c87fd640526b746a9deb3b2250d2518c
ToppCell10x3'2.3-week_17-19-Mesenchymal_osteo-stroma-chondrocyte|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

COL9A2 CILP2 ACAN C2orf72

5.83e-05177534915b848d789051a1c3bc6f6dc86955bb752276ab
ToppCellChildren_(3_yrs)-Epithelial-basal_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CELSR1 LRIG1 LGR4 LAMA5

5.96e-05178534fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCellAdult-Epithelial-lung_goblet_cell|Adult / Lineage, Cell type, age group and donor

CELSR1 ADAMTSL1 LRIG1 MUC5AC

6.09e-051795341fc1f252ca943a2f649d1e627f56acbf15f8e058
ToppCellEpithelial-basal_cell|World / Lineage, Cell type, age group and donor

CELSR1 LGR4 LAMA5 MMP3

6.09e-05179534d9be6647ec7b22747dc00dce4ea307b6af412dfa
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL9A2 CILP2 ACAN ADAMTS20

6.50e-05182534a1c0e4090a9e7aa4941a40c817d178de144888b6
ToppCelldroplet-Lung-nan-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 OTUD7A LTBP3 MMP3

6.64e-05183534ddc45fb591ba0ce3fa05c08051d58286a89ef835
ToppCelldroplet-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 OTUD7A LTBP3 MMP3

6.64e-05183534a253ad65673fce6cb453e709cb235ce7cbfa18b7
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL4A4 CELSR1 ADAMTSL1 LAMA5

6.78e-0518453429c95b814a0b1ad8734ed68b77df29c08594e5ec
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL9A2 CILP2 ACAN C2orf72

6.92e-051855348ed10ba581849c9c4ac4397226be2b62b4b3b900
ToppCelldroplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TGFB3 SHC2 CD248 LTBP3

6.92e-051855341b990e3089772be2b38c6d7ea0d1bf22461ae3ea
ToppCelldroplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TGFB3 RASL11B GJC2 MMP3

6.92e-05185534355b03c7ea438681e11a2b872c798c9ea26e1486
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL9A2 CILP2 ACAN C2orf72

6.92e-05185534b8052cebb73f41abe6faf0aa847be7c8ef23ae94
ToppCelldroplet-Tongue-nan-24m-Epithelial-parabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 FOXQ1 LGR4 VSIG8

7.07e-0518653418c06041c6c8a0ebac17b3c8aaebd67e652d315a
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL4A4 CELSR1 ADAMTSL1 LAMA5

7.22e-051875344ae7465174e0295d2c3b614b321a3b2f514dd22a
ToppCellfacs-Trachea-18m-Mesenchymal-myofibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL9A2 CILP2 ACAN TMEM102

7.37e-051885349d384c0934f1461bc37b1f83e0877d7bee2116ee
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL4A4 CELSR1 ADAMTSL1 LAMA5

7.37e-05188534eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCellfacs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL9A2 CILP2 ACAN TMEM102

7.37e-05188534340f0e3e65c7a00d82d26621ff37107458bebc41
ToppCell10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-chondrocyte|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

COL9A2 CILP2 GPR62 ACAN

7.37e-051885345a89587ee6f2b4dc14244bd88bb31efb81c50dbe
ToppCellMesenchymal-chondrocyte|World / Lineage, Cell type, age group and donor

COL9A2 CILP2 ACAN C2orf72

7.37e-051885347b1e3f8a941eaa68e89c562129a92314642eec66
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL4A4 SHC2 CD248 LTBP3

7.37e-05188534bba6b273bd47dd0e27fde914e9e6fc9d76fd5176
ToppCelltumor_Lung-Fibroblasts-Pericytes|Fibroblasts / Location, Cell class and cell subclass

CD248 ACAN LAMA5 C2orf72

7.52e-051895349c407b17d7945e81e1ae6c18452f5d20fb09d563
ToppCelldroplet-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TGFB3 CELSR1 ADAMTSL1 GJC2

7.68e-05190534e80d66ba0d5c263e94c1ab0b89d1dc7b837af3e1
ToppCelldroplet-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TGFB3 CELSR1 ADAMTSL1 GJC2

7.68e-05190534f32d66c0e74e0a2a23ecb857c4daf0d8573a806c
ToppCelldroplet-Lung-18m-Endothelial-lymphatic_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TGFB3 CELSR1 ADAMTSL1 GJC2

7.68e-05190534b79ffd05806244a9790cd04c66fb4f92c824e69f
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

COL9A2 CILP2 ACAN C2orf72

7.83e-05191534273c4a757292a9301de0eaeacdec91c9866be229
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TGFB3 ADAMTSL1 CD248 MMP3

7.83e-051915342b73fcd592d16cae8ded5e45c8fbf2d9adc8caad
ToppCelldroplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TGFB3 ADAMTSL1 SHC2 CD248

7.83e-05191534b51e0f5d1b93f526160c904e9091313a5364f3a7
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

COL9A2 CILP2 ACAN C2orf72

7.83e-05191534f9a46956778a8773d6656340ecf5d218376d79c2
ToppCellfacs-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB3 ADAMTSL1 CD248 LTBP3

7.99e-05192534a2c31390da4962bda9a936470b0b68fa1f5d47d1
ToppCellIPF-Epithelial-Basal|World / Disease state, Lineage and Cell class

CELSR1 LGR4 LAMA5 MMP3

7.99e-051925349b91e0b162e6f3ce86dd15cc33c2e745d069581f
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TGFB3 CD248 LTBP3 MMP3

7.99e-05192534011634a24b0c61d9b463fe755502edbc5cd70b7a
ToppCellfacs-Lung-nan-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB3 ADAMTSL1 CD248 LTBP3

7.99e-05192534eeab1cef7c36ae824381952c5b2c982368c379fd
ToppCell11.5-Airway-Mesenchymal-Cartilage|Airway / Age, Tissue, Lineage and Cell class

COL9A2 CILP2 ACAN C2orf72

8.15e-05193534d4779d92a4dd4b8b656383e6f4fce76d3bd70931
ToppCell18-Distal-Mesenchymal-Cartilage|Distal / Age, Tissue, Lineage and Cell class

COL9A2 CILP2 ACAN C2orf72

8.15e-0519353452f3d1bb8d8ca91ba12439d46392f377928ff8f8
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TGFB3 ADAMTSL1 CD248 MMP3

8.15e-05193534025836c5c5a711e477c326559e618e47cae42d11
ToppCelldroplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADAMTSL1 SHC2 CD248 MMP3

8.15e-0519353464edc1d6fb0fe117767d494cf4a5723bf8be2804
ToppCelldroplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TGFB3 SHC2 CD248 MMP3

8.32e-051945345594f7437448cb4b37d2d100f44d30c4a367df26
ToppCelldroplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADAMTSL1 RASL11B LTBP3 MMP3

8.32e-051945347826fe5eb254ac032de0d978f39585a40e0b3ee4
ToppCelldroplet-Lung-nan-21m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB3 ADAMTSL1 RASL11B MMP3

8.32e-0519453495dfbd9d9b8a47801edcfc35fb0d685901dcd2f8
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB3 CD248 LPP NOTCH2

8.32e-051945343bff2e4eb16719ab7419b2f94c9c6e7302aa6629
ToppCelldroplet-Lung-nan-21m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB3 ADAMTSL1 RASL11B MMP3

8.32e-051945342507f6dc7f1fe8b91fe1e24497d26d05afc3cd21
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB3 CD248 LPP LAMA5

8.32e-05194534b35e33439b6d3b5d69147e617224d2c8fd056223
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD248 RASL11B LTBP3 MMP3

8.32e-051945342d0cff9dc538a14518741e2a96d9d78442c81a72
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB3 CD248 LPP NOTCH2

8.32e-05194534fdaf61cbe7f77ff5358d150b38adb1fe3778e961
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TGFB3 FOXQ1 CD248 RASL11B

8.49e-051955342514c1f23424b5fc664d326d31ffd22bafe74ef8
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL9A2 FOXQ1 CD248 RASL11B

8.49e-05195534a486a7acea0e91048cc48afa0dbd3926d30bc217
ToppCellMesenchymal_cells-Fibro/Chondro_p.|Mesenchymal_cells / Lineage and Cell class

COL9A2 CILP2 ACAN MMP3

8.49e-05195534b95a631d54c6cf85e48e1e638703206aaaebc073
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL9A2 FOXQ1 CD248 RASL11B

8.49e-051955342414b158dc7bdec43a9671544bfb7ffc5f5168fd
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB3 CD248 LPP LAMA5

8.65e-05196534184104cbea0461dd2757668ab9755948ac7b585a
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB3 CD248 LPP LAMA5

8.65e-051965348114e98923096c54b6834f21550c3061bab6773d
ToppCellfacs-Lung-nan|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB3 ADAMTSL1 CD248 LTBP3

8.65e-05196534b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
DrugL696,418

ACAN MMP3

5.12e-062522CID000132967
DiseaseMilroy Disease

CELSR1 GJC2

2.69e-055492C1704423
Diseasedegenerative disc disease (biomarker_via_orthology)

ACAN MMP3

1.47e-0411492DOID:90 (biomarker_via_orthology)
Diseaseidiopathic scoliosis (implicated_via_orthology)

ZMYND10 SSPOP

3.19e-0416492DOID:0060250 (implicated_via_orthology)
Diseasegastric ulcer (biomarker_via_orthology)

MMP3 MUC5AC

5.56e-0421492DOID:10808 (biomarker_via_orthology)
DiseaseSjogren's syndrome (is_marker_for)

MMP3 MUC5AC

7.28e-0424492DOID:12894 (is_marker_for)
DiseaseCerebral Astrocytoma

MMP3 NOTCH2

7.91e-0425492C0750935
DiseaseIntracranial Astrocytoma

MMP3 NOTCH2

7.91e-0425492C0750936
DiseasePilocytic Astrocytoma

MMP3 NOTCH2

7.91e-0425492C0334583
DiseaseAstrocytoma

MMP3 NOTCH2

7.91e-0425492C0004114
DiseaseJuvenile Pilocytic Astrocytoma

MMP3 NOTCH2

7.91e-0425492C0280783
DiseaseDiffuse Astrocytoma

MMP3 NOTCH2

7.91e-0425492C0280785
DiseaseGrade I Astrocytoma

MMP3 NOTCH2

7.91e-0425492C1704230
DiseaseSubependymal Giant Cell Astrocytoma

MMP3 NOTCH2

7.91e-0425492C0205768
DiseaseMixed oligoastrocytoma

MMP3 NOTCH2

7.91e-0425492C0547065
DiseaseChildhood Cerebral Astrocytoma

MMP3 NOTCH2

7.91e-0425492C0338070
DiseaseGemistocytic astrocytoma

MMP3 NOTCH2

8.56e-0426492C0334581
DiseaseProtoplasmic astrocytoma

MMP3 NOTCH2

8.56e-0426492C0334580
DiseaseFibrillary Astrocytoma

MMP3 NOTCH2

8.56e-0426492C0334582
DiseaseAnaplastic astrocytoma

MMP3 NOTCH2

9.23e-0427492C0334579
Diseaseobsolete aging

COL4A4 CD248 ACAN LTBP3

1.19e-03279494GO_0007568

Protein segments in the cluster

PeptideGeneStartEntry
PRSDFYPAIGDICCA

TDRD1

536

Q9BXT4
AAAYCPGLPASCLAV

C2orf72

181

A6NCS6
RAACGPSSCYALFPR

CD248

26

Q9HCU0
PYVSRCAVCEAPAQA

COL4A4

1561

P53420
PGCTYAVGAACTPRA

CELSR1

46

Q9NYQ6
PAAAAAGYGCPLLSD

AHDC1

1531

Q5TGY3
PFATAGDCYSAFRCP

ADAMTS20

1831

P59510
APAHALQCRDGYEPC

NOTCH2

21

Q04721
PYGCACLAPAARAAE

GPR62

256

Q9BZJ7
VTAAAGPRAPCAAAC

LRIG1

31

Q96JA1
ALCCGLLAPAARAGY

METRN

11

Q9UJH8
PGCDNVCYDAFAPLS

GJC2

61

Q5T442
ALAECCAPFEPGQRY

GMIP

331

Q9P107
CVAVCSAYPLDGAAR

MMP3

11

P08254
ECEGPKPASQRACYA

ADAMTSL1

566

Q8N6G6
NPPADEYFGRCARCG

LPP

406

Q93052
CPALAVASCQRPEGY

LGR4

881

Q9BXB1
ARAIPTYQEGACCPV

MUC5AC

5361

P98088
DEACAPAVGALRPCA

OTUD7A

781

Q8TE49
PRCEICAPGFYGNAL

LAMA5

2001

O15230
AAAPARSCAEEPCGA

ACAN

2276

P16112
CLAYPCAGAAVLSPG

PTF1A

121

Q7RTS3
CLEPYTACDLAPRAG

ALPG

486

P10696
LSALAACCPGAVDFP

SLC35C1

91

Q96A29
PGFCEPAACLGASAY

COL9A2

661

Q14055
FRCTCAQGYAPAPDG

LTBP3

766

Q9NS15
AAAAASLPPFACGAC

FIZ1

191

Q96SL8
ACDPRSGLVAYPAGC

MAPKBP1

56

O60336
SAVQGPPERDLCGCY

IGHA2

156

P01877
RYGAAPAAPRCDALD

FKRP

181

Q9H9S5
APRAEAAPVCCSARY

SLC17A5

26

Q9NRA2
PCRALLPLCAYGAGE

FOXQ1

316

Q9C009
AEYPAPGNAAASDCC

RASL11B

11

Q9BPW5
LGLDCPGRDYPNICA

UPP1

76

Q16831
CPCQLGARRYAPGSA

SSPOP

881

A2VEC9
QAFCPRELVYAPGAC

SSPOP

921

A2VEC9
REACPSYATCPVDGA

SSPOP

3461

A2VEC9
CCLAGRAYPLGDIPE

VPS8

731

Q8N3P4
AAPPALCYCSVLLRG

INTS5

866

Q6P9B9
AVGLCAPIYCVSPAN

SERPINA9

11

Q86WD7
GPAYLDVGLCPDTRC

CILP2

406

Q8IUL8
ACLPAFCDADRPDAY

CILP2

791

Q8IUL8
AFRLGCPPCGDYSER

ZNF837

336

Q96EG3
ERPYACPECGKAFSR

ZFP92

261

A6NM28
CTAAAACEAGPSPVY

VSIG8

376

P0DPA2
RPYACADCGKSFADP

ZNF668

166

Q96K58
AAAVLGACEPRCAAP

SHC2

76

P98077
AAPAAAAPGYGQSCC

SAP30L

16

Q9HAJ7
CCAYPPGAFVSVSRD

PLAA

26

Q9Y263
ALYLARPENAGACCL

TMEM102

421

Q8N9M5
IACAAAAAAAACLPG

TMCC1

171

O94876
AYPCGLCLQRAPASN

USP17L8

251

P0C7I0
AVAPERPRCAYCSAE

ZMYND10

386

O75800
GYSCPECARVFASPL

ZNF580

91

Q9UK33
ANFCSGPCPYLRSAD

TGFB3

341

P10600
APASAERPYKCAECG

ZNF628

446

Q5EBL2