Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	TRPM_tetra	TRPM3 TRPM7	2.54e-05	4	39	2	PF16519
Domain	TRPM_tetra	TRPM3 TRPM7	2.54e-05	4	39	2	IPR032415
Domain	-	SCYL2 COPG2 RICTOR ARID1B	1.15e-03	222	39	4	1.25.10.10
Domain	Helicase_C	CHD6 MTREX HELQ	1.44e-03	107	39	3	PF00271
Domain	HELICc	CHD6 MTREX HELQ	1.44e-03	107	39	3	SM00490
Domain	Helicase_C	CHD6 MTREX HELQ	1.48e-03	108	39	3	IPR001650
Domain	HELICASE_CTER	CHD6 MTREX HELQ	1.52e-03	109	39	3	PS51194
Domain	HELICASE_ATP_BIND_1	CHD6 MTREX HELQ	1.52e-03	109	39	3	PS51192
Domain	DEXDc	CHD6 MTREX HELQ	1.52e-03	109	39	3	SM00487
Domain	Helicase_ATP-bd	CHD6 MTREX HELQ	1.56e-03	110	39	3	IPR014001
Domain	ARM-like	SCYL2 COPG2 RICTOR ARID1B	2.36e-03	270	39	4	IPR011989
Domain	ARM-type_fold	SCYL2 COPG2 RICTOR DIAPH3	5.32e-03	339	39	4	IPR016024
Domain	HEAT_REPEAT	SCYL2 COPG2	9.38e-03	70	39	2	PS50077
Domain	DEAD	MTREX HELQ	1.02e-02	73	39	2	PF00270
Domain	DEAD/DEAH_box_helicase_dom	MTREX HELQ	1.02e-02	73	39	2	IPR011545
Pubmed	Loss of gremlin delays primordial follicle assembly but does not affect female fertility in mice.	AMHR2 GREM1	1.23e-06	2	39	2	21832168
Pubmed	Functional proteomics mapping of a human signaling pathway.	SCYL2 CHD6 ARID1B DIAPH3 RGS3 ANKRD27	4.75e-05	591	39	6	15231748
Pubmed	Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1.	PTCH2 GREM1	8.03e-05	12	39	2	11389830
Pubmed	Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs.	PTCH2 GREM1	8.03e-05	12	39	2	24990743
Pubmed	Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons.	TRPM3 TRPM7	8.03e-05	12	39	2	19850157
Pubmed	Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development.	PTCH2 GREM1	9.48e-05	13	39	2	25448692
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DNHD1 MTREX OVCH1 POP1	1.37e-04	234	39	4	36243803
Pubmed	The LIFEdb database in 2006.	MKKS GPR155 HDHD2 ANKRD27 RASGRP3 PASD1	1.41e-04	720	39	6	16381901
Pubmed	From ORFeome to biology: a functional genomics pipeline.	MKKS GPR155 HDHD2 ANKRD27 RASGRP3 PASD1	1.43e-04	722	39	6	15489336
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	MKKS GPR155 HDHD2 TRPM3 ANKRD27 RASGRP3	1.75e-04	750	39	6	11230166
Pubmed	Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia.	TRPM3 TRPM7	1.85e-04	18	39	2	31911949
Pubmed	DNA cloning using in vitro site-specific recombination.	MKKS GPR155 HDHD2 ANKRD27 RASGRP3 PASD1	2.38e-04	794	39	6	11076863
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	SCYL2 CHD6 MTREX POP1	2.78e-04	282	39	4	23667531
Pubmed	Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb.	PTCH2 GREM1	3.05e-04	23	39	2	19783740
Pubmed	Mapping the expression of transient receptor potential channels across murine placental development.	TRPM3 TRPM7	3.33e-04	24	39	2	33884443
Pubmed	T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number.	PTCH2 GREM1	3.62e-04	25	39	2	27046536
Pubmed	International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.	TRPM3 TRPM7	3.62e-04	25	39	2	16382100
Pubmed	An introduction to TRP channels.	TRPM3 TRPM7	4.23e-04	27	39	2	16460286
Pubmed	ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.	DNHD1 CHD6	4.23e-04	27	39	2	17525332
Pubmed	Functional specialization of beta-arrestin interactions revealed by proteomic analysis.	SCYL2 PTCH2 IGF2BP2 RGS3	4.33e-04	317	39	4	17620599
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	MKKS RICTOR NUBPL ANKRD27 FPGS	5.57e-04	606	39	5	36538041
Pubmed	GRAMD4 inhibits tumour metastasis by recruiting the E3 ligase ITCH to target TAK1 for degradation in hepatocellular carcinoma.	COPG2 MTREX	6.33e-04	33	39	2	34841685
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	TRPM3 TRPM7	6.33e-04	33	39	2	19834762
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	RICTOR MTREX RGS3 ANKRD27 POP1	7.64e-04	650	39	5	38777146
Pubmed	Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.	MTREX POP1	1.03e-03	42	39	2	7584044
Pubmed	Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.	ARID1B IGF2BP2	1.07e-03	43	39	2	36950384
GeneFamily	X-linked mental retardation\|RNA helicases	MTREX HELQ	7.72e-05	11	22	2	1168
GeneFamily	Transient receptor potential cation channels	TRPM3 TRPM7	5.24e-04	28	22	2	249
GeneFamily	Adenosine receptors\|V-set domain containing	BTN2A1 SCN4B	1.66e-02	163	22	2	590
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	RICTOR CHD6 ARID1B IGF2BP2 MTREX	6.87e-07	192	39	5	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	RICTOR CHD6 ARID1B IGF2BP2 MTREX	7.05e-07	193	39	5	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	Striatum-Macroglia\|Striatum / BrainAtlas - Mouse McCarroll V32	RNASEH2B ARHGEF19 DIAPH3 RGS3	1.99e-05	184	39	4	9ed6a7c7171823b72561db9a6c1de47e82edc4c9
ToppCell	Caecum-T_cell-Tfh\|T_cell / Region, Cell class and subclass	PTCH2 CHD6 ZIK1 GREM1	2.55e-05	196	39	4	fe2ee5788028e6b671674f0cc50e2b6379f50976
Disease	MASA syndrome (implicated_via_orthology)	TRPM3 TRPM7	3.03e-05	7	36	2	DOID:0060246 (implicated_via_orthology)
Disease	Neuroblastoma	CHD6 ARID1B	1.51e-03	47	36	2	C0027819
Disease	sitting height ratio	ARID1B HDHD2	1.78e-03	51	36	2	EFO_0007118
Disease	polychlorinated biphenyls measurement	NUBPL RASGRP3	2.87e-03	65	36	2	EFO_0007042
Disease	Colorectal Neoplasms	GREM1 TRPM7 FPGS	4.65e-03	277	36	3	C0009404
Disease	Uterine leiomyoma	MFSD6L IGF2BP2	5.54e-03	91	36	2	HP_0000131
Disease	Weight Gain	COPG2 HDHD2	6.91e-03	102	36	2	C0043094

Protein segments in the cluster

Peptide	Gene	Start	Entry
LAALLPEALGKLPLH	BPIFB3	316	P59826
SKHPGLVLILGKLIL	ARID1B	2036	Q8NFD5
VPERGLLLIGLQVLH	DNHD1	4646	Q96M86
HEGLGLLLDILEKLI	DIAPH3	216	Q9NSV4
LLSGPLLVLELHPKG	AMHR2	271	Q16671
ILLGLTGDPHLQVLL	OR6C2	11	Q9NZP2
LLPHKHDIITLLGVG	CRYZL1	241	O95825
VLLLHIIEGKGLISK	RGS3	151	P49796
LSLKLQGIPGHVFLL	ARHGEF19	656	Q8IW93
AALHGRADLIPLLLK	ANKRD27	751	Q96NW4
EGHIILGKSLIVPLK	MKKS	191	Q9NPJ1
LLLLLGTLLPAAEGK	GREM1	11	O60565
IPALLVGVLLITGKH	GPR155	491	Q7Z3F1
FRLLLDGAPLIAIHK	HDHD2	131	Q9H0R4
LLGEILLHPFKATLL	MFSD6L	411	Q8IWD5
PLKILAHNGLVGRLI	IGF2BP2	276	Q9Y6M1
KPALSHLGDKGLLLL	RICTOR	791	Q6R327
GHLPAEIVGKKLLSL	PASD1	66	Q8IV76
LILGPHESKIPILLI	POP1	586	Q99575
VLIDKLLPKLIAGGH	CHD6	786	Q8TD26
LLPKLIAGGHKVLIF	CHD6	791	Q8TD26
LATKILHLLGKEGPR	COPG2	451	Q9UBF2
AILHLVVAGLGSKPL	BTN2A1	136	Q7KYR7
LHLVGGVLKLLEPAL	FPGS	571	Q05932
KGLEGLVLESLLHLI	HELQ	856	Q8TDG4
LGLEVLGDIPLHLNI	NUBPL	266	Q8TB37
HLLGLLLIAKEEGLP	CROT	506	Q9UKG9
LHFPGGLILIEKELA	TCP11X2	351	Q5H9J9
LLLVIGHPRSLGLKC	OVCH1	11	Q7RTY7
GFKIPILGVHLKDLI	RASGRP3	296	Q8IV61
LHGLVLLPVLLSILG	PTCH2	1101	Q9Y6C5
GGVIGLLILILLIKK	SCN4B	171	Q8IWT1
LAGKVLPHLIPLSIE	SCYL2	566	Q6P3W7
SPGLHIGLIIILAIM	CHPT1	266	Q8WUD6
HGGLLPILKETIEIL	MTREX	456	P42285
ILLLKLPGLEKLLHH	RNASEH2B	126	Q5TBB1
QLELPKLLISVHGGL	TRPM3	176	Q9HCF6
VPVLKDILHLADLPG	ZIK1	106	Q3SY52
FELHPRIKQLLGKGL	TRPM7	146	Q96QT4
LLGLGIILGHFAIPK	NAALADL1	16	Q9UQQ1