Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncytoskeletal protein binding

TPR DLG5 MAP1A SPTAN1 SPTBN1 SPTBN2 NUMA1 VPS16 PSTPIP2 MAST2 MEFV STARD9 KIF4B GNB1 KIF17 NLRP5

9.60e-0510999916GO:0008092
GeneOntologyMolecularFunctiondynein complex binding

TPR CNTRL NUMA1

3.54e-0428993GO:0070840
GeneOntologyMolecularFunctionRNA helicase activity

DDX50 EIF4A1 DDX53 DHX29

6.12e-0478994GO:0003724
GeneOntologyMolecularFunctionhistone H3K4 monomethyltransferase activity

KMT2B KMT2A

6.68e-048992GO:0140945
GeneOntologyMolecularFunctionATP-dependent activity, acting on RNA

DDX50 EIF4A1 DDX53 DHX29

6.74e-0480994GO:0008186
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

KMT2B KMT2A

1.07e-0310992GO:0140999
GeneOntologyMolecularFunctionunmethylated CpG binding

KMT2B KMT2A

1.07e-0310992GO:0045322
GeneOntologyMolecularFunctionhelicase activity

DDX50 EIF4A1 SMARCA4 DDX53 DHX29

1.14e-03158995GO:0004386
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF765 ZNF845 ZNF813 ZNF320 ZNF28 ZNF544 ZNF655 ZNF286B SMARCA4 ZNF888 ZNF525 ZNF761 ZNF468 ZNF160 MGA

1.17e-0312449915GO:0000978
GeneOntologyMolecularFunctionS-methyltransferase activity

BHMT2 KMT2A

1.30e-0311992GO:0008172
GeneOntologyMolecularFunctiontubulin binding

TPR MAP1A NUMA1 MAST2 STARD9 KIF4B KIF17 NLRP5

1.30e-03428998GO:0015631
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF765 ZNF845 ZNF813 ZNF320 ZNF28 ZNF544 ZNF655 ZNF286B SMARCA4 ZNF888 ZNF525 ZNF761 ZNF468 ZNF160 MGA

1.45e-0312719915GO:0000987
GeneOntologyMolecularFunctioncadherin binding

DAB2IP SPTAN1 SPTBN1 SPTBN2 BMPR2 CCNB2 DHX29

1.50e-03339997GO:0045296
GeneOntologyMolecularFunctionphosphatidylinositol-3-phosphate binding

DAB2IP SESTD1 ATG2B

1.74e-0348993GO:0032266
GeneOntologyMolecularFunctiontranslation initiation factor activity

EIF4A1 EIF4E DHX29

2.07e-0351993GO:0003743
GeneOntologyBiologicalProcessmitotic cell cycle process

TPR SPTBN1 NUMA1 LATS1 APPL2 CCNB2 ZNF655 CRLF3 EIF4E SNX18 SMARCA4 LRP5 KIF4B MAD2L1 PCNT

1.34e-058549915GO:1903047
GeneOntologyCellularComponentspectrin

SPTAN1 SPTBN1 SPTBN2

8.74e-0691003GO:0008091
DomainSpectrin/alpha-actinin

SESTD1 TRIO SPTAN1 SPTBN1 SPTBN2

7.14e-07321005IPR018159
DomainSPEC

SESTD1 TRIO SPTAN1 SPTBN1 SPTBN2

7.14e-07321005SM00150
DomainSpectrin

TRIO SPTAN1 SPTBN1 SPTBN2

6.34e-06231004PF00435
DomainP-loop_NTPase

DLG5 DIRAS1 SPEF2 LRRK1 NLRP14 DDX50 STARD9 EIF4A1 SMARCA4 KIF4B CARD11 DDX53 GNAL KIF17 DHX29 NLRP5

1.07e-0584810016IPR027417
DomainSpectrin_repeat

TRIO SPTAN1 SPTBN1 SPTBN2

1.66e-05291004IPR002017
DomainMeTrfase_trithorax

KMT2B KMT2A

2.84e-0521002IPR016569
DomainDUF3498

DAB2IP SYNGAP1

8.48e-0531002IPR021887
DomainDUF3498

DAB2IP SYNGAP1

8.48e-0531002PF12004
DomainPH

DAB2IP TRIO DOCK11 SPTBN1 SPTBN2 SYNGAP1 APPL2 SPATA13

1.24e-042781008SM00233
DomainPH_DOMAIN

DAB2IP TRIO DOCK11 SPTBN1 SPTBN2 SYNGAP1 APPL2 SPATA13

1.27e-042791008PS50003
DomainKRAB

ZNF765 ZNF845 ZNF813 ZNF320 ZNF28 ZNF544 ZNF761 ZNF468 ZNF160

1.30e-043581009PS50805
DomainKRAB

ZNF765 ZNF845 ZNF813 ZNF320 ZNF28 ZNF544 ZNF761 ZNF468 ZNF160

1.30e-043581009PF01352
DomainPH_domain

DAB2IP TRIO DOCK11 SPTBN1 SPTBN2 SYNGAP1 APPL2 SPATA13

1.30e-042801008IPR001849
Domain-

DLG5 MEFV NLRP14 CARD11 NLRP5

1.42e-049310051.10.533.10
DomainKRAB

ZNF765 ZNF845 ZNF813 ZNF320 ZNF28 ZNF544 ZNF761 ZNF468 ZNF160

1.63e-043691009SM00349
DomainZF_PHD_1

KMT2B KDM5C PHF20L1 KMT2A UHRF2

1.65e-04961005PS01359
DomainKRAB

ZNF765 ZNF845 ZNF813 ZNF320 ZNF28 ZNF544 ZNF761 ZNF468 ZNF160

1.66e-043701009IPR001909
DomainFAM47

FAM47A FAM47B

1.69e-0441002PF14642
DomainFAM47

FAM47A FAM47B

1.69e-0441002IPR032743
DomainSpectrin_bsu

SPTBN1 SPTBN2

1.69e-0441002IPR016343
DomainDEATH-like_dom

DLG5 MEFV NLRP14 CARD11 NLRP5

1.91e-04991005IPR011029
DomainDAPIN

MEFV NLRP14 NLRP5

2.13e-04221003PS50824
DomainPYRIN

MEFV NLRP14 NLRP5

2.13e-04221003PF02758
DomainDAPIN

MEFV NLRP14 NLRP5

2.13e-04221003IPR004020
DomainPYRIN

MEFV NLRP14 NLRP5

2.13e-04221003SM01289
DomainPH

TRIO DOCK11 SPTBN1 SPTBN2 SYNGAP1 APPL2 SPATA13

2.31e-042291007PF00169
DomainHelicase_C

DDX50 EIF4A1 SMARCA4 DDX53 DHX29

2.75e-041071005PF00271
DomainHELICc

DDX50 EIF4A1 SMARCA4 DDX53 DHX29

2.75e-041071005SM00490
DomainFYrich_C

KMT2B KMT2A

2.81e-0451002IPR003889
DomainFYrich_N

KMT2B KMT2A

2.81e-0451002IPR003888
DomainFYRC

KMT2B KMT2A

2.81e-0451002SM00542
DomainFYRN

KMT2B KMT2A

2.81e-0451002SM00541
DomainFYRN

KMT2B KMT2A

2.81e-0451002PF05964
DomainFYRC

KMT2B KMT2A

2.81e-0451002PF05965
DomainFYRC

KMT2B KMT2A

2.81e-0451002PS51543
DomainFYRN

KMT2B KMT2A

2.81e-0451002PS51542
DomainHelicase_C

DDX50 EIF4A1 SMARCA4 DDX53 DHX29

2.87e-041081005IPR001650
DomainHELICASE_CTER

DDX50 EIF4A1 SMARCA4 DDX53 DHX29

2.99e-041091005PS51194
DomainHELICASE_ATP_BIND_1

DDX50 EIF4A1 SMARCA4 DDX53 DHX29

2.99e-041091005PS51192
DomainDEXDc

DDX50 EIF4A1 SMARCA4 DDX53 DHX29

2.99e-041091005SM00487
DomainHelicase_ATP-bd

DDX50 EIF4A1 SMARCA4 DDX53 DHX29

3.12e-041101005IPR014001
Domainzf-C2H2

ZNF765 ZNF845 ZNF813 ZNF320 ZNF28 ZNF544 ZNF655 ZNF286B ZNF525 ZNF761 ZNF468 ZNF160

3.28e-0469310012PF00096
Domain-

DLG5 DIRAS1 SPEF2 LRRK1 NLRP14 DDX50 EIF4A1 SMARCA4 CARD11 DDX53 GNAL DHX29

6.33e-04746100123.40.50.300
DomainDEAD/DEAH_box_helicase_dom

DDX50 EIF4A1 DDX53 DHX29

6.34e-04731004IPR011545
DomainDEAD

DDX50 EIF4A1 DDX53 DHX29

6.34e-04731004PF00270
DomainPHD

KMT2B KDM5C KMT2A UHRF2

7.03e-04751004PF00628
DomainZnf_PHD-finger

KMT2B KDM5C KMT2A UHRF2

8.55e-04791004IPR019787
DomainZINC_FINGER_C2H2_2

ZNF765 ZNF845 ZNF813 ZNF320 ZNF28 ZNF544 ZNF655 ZNF286B ZNF525 ZNF761 ZNF468 ZNF160

8.83e-0477510012PS50157
DomainZINC_FINGER_C2H2_1

ZNF765 ZNF845 ZNF813 ZNF320 ZNF28 ZNF544 ZNF655 ZNF286B ZNF525 ZNF761 ZNF468 ZNF160

9.03e-0477710012PS00028
DomainPH_dom-spectrin-type

SPTBN1 SPTBN2

9.97e-0491002IPR001605
DomainQ_MOTIF

DDX50 EIF4A1 DDX53

1.01e-03371003PS51195
DomainRNA_helicase_DEAD_Q_motif

DDX50 EIF4A1 DDX53

1.01e-03371003IPR014014
Domain-

ZNF765 ZNF845 ZNF813 ZNF320 ZNF28 ZNF544 ZNF655 ZNF286B ZNF761 ZNF468 ZNF160

1.02e-03679100113.30.160.60
DomainZnf_FYVE_PHD

KMT2B KDM5C PHF20L1 KMT2A UHRF2

1.17e-031471005IPR011011
Domain-

DAB2IP TRIO DOCK11 SPTBN1 SPTBN2 SYNGAP1 APPL2 SPATA13

1.20e-0339110082.30.29.30
DomainZnf_C2H2/integrase_DNA-bd

ZNF765 ZNF845 ZNF813 ZNF320 ZNF28 ZNF544 ZNF655 ZNF286B ZNF761 ZNF468 ZNF160

1.21e-0369410011IPR013087
DomainZnf_C2H2

ZNF765 ZNF845 ZNF813 ZNF320 ZNF28 ZNF544 ZNF655 ZNF286B ZNF525 ZNF761 ZNF468 ZNF160

1.22e-0380510012IPR007087
DomainZnF_C2H2

ZNF765 ZNF845 ZNF813 ZNF320 ZNF28 ZNF544 ZNF655 ZNF286B ZNF525 ZNF761 ZNF468 ZNF160

1.26e-0380810012SM00355
DomainPHD

KMT2B KDM5C KMT2A UHRF2

1.33e-03891004SM00249
DomainKinesin_motor_CS

STARD9 KIF4B KIF17

1.37e-03411003IPR019821
DomainZnf_PHD

KMT2B KDM5C KMT2A UHRF2

1.45e-03911004IPR001965
Domainzf-C2H2_6

ZNF765 ZNF845 ZNF813 ZNF320 ZNF761 ZNF468 ZNF160

1.50e-033141007PF13912
DomainZnf_CXXC

KMT2B KMT2A

1.51e-03111002IPR002857
DomainZF_CXXC

KMT2B KMT2A

1.51e-03111002PS51058
Domainzf-CXXC

KMT2B KMT2A

1.51e-03111002PF02008
DomainKINESIN_MOTOR_1

STARD9 KIF4B KIF17

1.68e-03441003PS00411
Domain-

STARD9 KIF4B KIF17

1.68e-034410033.40.850.10
DomainKinesin_motor_dom

STARD9 KIF4B KIF17

1.68e-03441003IPR001752
DomainKinesin

STARD9 KIF4B KIF17

1.68e-03441003PF00225
DomainKINESIN_MOTOR_2

STARD9 KIF4B KIF17

1.68e-03441003PS50067
DomainKISc

STARD9 KIF4B KIF17

1.68e-03441003SM00129
DomainZF_PHD_2

KMT2B KDM5C KMT2A UHRF2

1.70e-03951004PS50016
DomainPH_dom-like

DAB2IP TRIO DOCK11 SPTBN1 SPTBN2 SYNGAP1 APPL2 SPATA13

2.05e-034261008IPR011993
DomainRasGAP

DAB2IP SYNGAP1

2.48e-03141002SM00323
DomainLdl_recept_b

LRP1B LRP5

2.48e-03141002PF00058
DomainLDLRB

LRP1B LRP5

2.48e-03141002PS51120
DomainRasGAP_CS

DAB2IP SYNGAP1

2.48e-03141002IPR023152
DomainSTART

STARD13 STARD9

2.85e-03151002PF01852
DomainRasGAP

DAB2IP SYNGAP1

2.85e-03151002PF00616
DomainRAS_GTPASE_ACTIV_1

DAB2IP SYNGAP1

2.85e-03151002PS00509
DomainSTART_lipid-bd_dom

STARD13 STARD9

2.85e-03151002IPR002913
DomainRAS_GTPASE_ACTIV_2

DAB2IP SYNGAP1

2.85e-03151002PS50018
DomainSTART

STARD13 STARD9

2.85e-03151002PS50848
DomainLY

LRP1B LRP5

2.85e-03151002SM00135
DomainLDLR_classB_rpt

LRP1B LRP5

2.85e-03151002IPR000033
DomainPost-SET_dom

KMT2B KMT2A

3.24e-03161002IPR003616
DomainPostSET

KMT2B KMT2A

3.24e-03161002SM00508
Domain-

DAB2IP SYNGAP1

3.24e-031610021.10.506.10
DomainPOST_SET

KMT2B KMT2A

3.24e-03161002PS50868
DomainLeu-rich_rpt

CNTRL LRRC2 DNAAF11 LRRK1 NLRP14 NLRP5

3.37e-032711006IPR001611
DomainZnf_C2H2-like

ZNF765 ZNF845 ZNF813 ZNF320 ZNF28 ZNF544 ZNF655 ZNF286B ZNF761 ZNF468 ZNF160

3.53e-0379610011IPR015880
DomainRasGAP_dom

DAB2IP SYNGAP1

4.11e-03181002IPR001936
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SPTAN1 SPTBN1 SPTBN2

1.56e-0510733MM15112
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

DAB2IP TPR SESTD1 TRIO DOCK11 SPTAN1 SPTBN1 SPTBN2 HECTD4 NUMA1 SEC31A SYNGAP1 EIF4A1 STRN4 SMARCA4 CCAR2 KIF4B GNB1 MGA SPATA13 PCNT

9.13e-139631042128671696
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SMIM24 STARD13 SPEF2 SPTAN1 SPTBN1 CNTRL SPTBN2 NUMA1 FAM47B LATS1 DDX50 PHF20L1 STARD9 EIF4A1 STRN4 KMT2A CCAR2 GNB1 SPATA13 PCNT

9.10e-0914421042035575683
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SESTD1 RAP1GDS1 TRIO SPTAN1 SPTBN1 SPTBN2 HECTD4 SEC31A LRP1B FAN1 SYNGAP1 APPL2 GRHPR ZNF655 EIF4A1 SMARCA4 GNB1 PCNT

4.80e-0812851041835914814
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

DAB2IP SESTD1 MAP1A TRIO SPTAN1 SPTBN1 SPTBN2 SYNGAP1 GNB1

1.81e-07281104928706196
Pubmed

A human MAP kinase interactome.

TPR RAP1GDS1 MAP1A SPTAN1 SPTBN1 CNTRL SPTBN2 SEC31A LATS1 MGA GAREM1

2.46e-074861041120936779
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

DLG5 TRIO CNTRL SPTBN2 MAST2 LRP1B LATS1 CCNB2 EIF4E SNX18 POC5 GNB1 MGA PCNT

2.65e-078531041428718761
Pubmed

ST3GAL1 and βII-spectrin pathways control CAR T cell migration to target tumors.

SPTAN1 SPTBN1 SPTBN2

5.16e-076104337069398
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

DAB2IP TRIO CDKN2AIP SPTAN1 SPTBN1 SPTBN2 PSTPIP2 FAN1 DDX50 CCNB2 CRLF3 CCAR2 POC5 MAD2L1 PCNT

5.49e-0710491041527880917
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

TPR SPTAN1 SPTBN1 SPTBN2 NUMA1 FRYL ZCCHC3 EIF4A1 SMARCA4 KMT2A CCAR2 PCNT

6.23e-076531041222586326
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

TPR KMT2B SPTAN1 SPTBN2 ATG2B NUMA1 LATS1 STRN4 SMARCA4 KMT2A MGA

8.15e-075491041138280479
Pubmed

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

TPR KDM5C SPTAN1 HECTD4 FAN1 DDX50 SMARCA4 DHX29

9.06e-07250104833536335
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DAB2IP NDOR1 KMT2B DIRAS1 TRIO HECTD4 FRYL LRRK1 MAST2 NAPRT STRN4 LRP5 SPATA13 GAREM1 PCNT

1.05e-0611051041535748872
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

TPR SPTAN1 SPTBN1 SPTBN2 NUMA1 VPS16 EIF4A1 SMARCA4 LRP5 CCAR2 GNB1 DHX29 PCNT

1.54e-068471041335235311
Pubmed

A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.

TPR DLG5 SPTAN1 SPTBN1 SNED1 PCNT

1.55e-06118104630979931
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

TPR CDKN2AIP NUMA1 PHF20L1 CCNB2 EIF4A1 EIF4E STRN4 SMARCA4 CCAR2 KIF4B POC5 GNAL GNB1 MAD2L1

1.81e-0611551041520360068
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

DLG5 TRIO DOCK11 SPTAN1 SPTBN1 FRYL MAST2 BMPR2 LATS1 STARD9 ZNF286B KMT2A SPATA13

1.84e-068611041336931259
Pubmed

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.

KLHL6 DAB2IP TRIO SPTAN1 SPTBN1 NUMA1 KIF4B PCNT

2.34e-06284104829459677
Pubmed

Cell organization, growth, and neural and cardiac development require αII-spectrin.

SPTAN1 SPTBN1 SPTBN2

3.07e-0610104322159418
Pubmed

Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.

SPTAN1 SPTBN1 SPTBN2

4.21e-0611104317607528
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

TPR NUMA1 KMT2A UHRF2 MGA

6.23e-0686104537253089
Pubmed

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.

TPR CDKN2AIP SPTAN1 SPTBN1 SPTBN2 FRYL ZCCHC3 EIF4A1 CCAR2 MGA

6.33e-065511041034728620
Pubmed

alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.

SPTAN1 SPTBN1 SPTBN2

7.27e-0613104318796539
Pubmed

Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.

KMT2B KDM5C KMT2A

7.27e-0613104324619213
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

TPR KDM5C SPTAN1 SPTBN1 NUMA1 EIF4A1 SMARCA4 CCAR2

7.37e-06332104832786267
Pubmed

KMT2A and KMT2B Mediate Memory Function by Affecting Distinct Genomic Regions.

KMT2B KMT2A

8.86e-062104228723559
Pubmed

Translocation (4;11)(p12;q23) with rearrangement of FRYL and MLL in therapy-related acute myeloid leukemia.

FRYL KMT2A

8.86e-062104217854671
Pubmed

Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation.

KDM5C KMT2A

8.86e-062104232483278
Pubmed

Characterization of a new beta-spectrin gene which is predominantly expressed in brain.

SPTAN1 SPTBN2

8.86e-06210429675416
Pubmed

Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia.

DAB2IP KMT2A

8.86e-062104214978793
Pubmed

Identification of a mouse brain beta-spectrin cDNA and distribution of its mRNA in adult tissues.

SPTAN1 SPTBN1

8.86e-06210421742606
Pubmed

Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase.

EIF4A1 CARD11

8.86e-062104225320244
Pubmed

AF4p12, a human homologue to the furry gene of Drosophila, as a novel MLL fusion partner.

FRYL KMT2A

8.86e-062104216061630
Pubmed

Spectrin-actin interaction is required for neurite extension in NB 2a/dl neuroblastoma cells.

SPTAN1 SPTBN1

8.86e-06210428776664
Pubmed

Mad2 promotes Cyclin B2 recruitment to the kinetochore for guiding accurate mitotic checkpoint.

CCNB2 MAD2L1

8.86e-062104235384228
Pubmed

Cloning of a portion of the chromosomal gene and cDNA for human beta-fodrin, the nonerythroid form of beta-spectrin.

SPTAN1 SPTBN1

8.86e-06210428406479
Pubmed

Caspase-3/7-mediated Cleavage of β2-spectrin is Required for Acetaminophen-induced Liver Damage.

SPTBN1 SPTBN2

8.86e-062104226884715
Pubmed

Differential Regulation of the Melanoma Proteome by eIF4A1 and eIF4E.

EIF4A1 EIF4E

8.86e-062104227879264
Pubmed

The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases.

RAP1GDS1 DIRAS1

8.86e-062104226814130
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

DAB2IP TRIO SPTAN1 SPTBN1 SPTBN2 SYNGAP1 GNB1

1.10e-05251104727507650
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

STARD13 TPR SPTAN1 SPTBN1 NUMA1 OAS3 SEC31A VPS16 DDX50 GRHPR EIF4A1 SMARCA4 CCAR2 MGA DHX29

1.21e-0513531041529467282
Pubmed

Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate.

TPR SPTBN1 NUMA1

1.71e-0517104321628590
Pubmed

MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair.

TPR PHF20L1 CCAR2

1.71e-0517104320479123
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF845 ZNF813 ZNF320 ZNF655 ZNF468 ZNF160

1.82e-05181104637372979
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

TRIO SPTBN1 LAMA2 LRRC2 SEC31A MAST2 APPL2 ZNF160 MGA

1.91e-05497104923414517
Pubmed

Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.

SPTAN1 SPTBN1 SPTBN2

2.05e-0518104312119179
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

TPR KMT2B KDM5C SPTAN1 SPTBN1 NUMA1 LATS1 SMARCA4 KMT2A CCAR2 DHX29

2.11e-057741041115302935
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

TPR TRIO SPTAN1 SPTBN1 NUMA1 SEC31A MAST2 DDX50 STARD9 EIF4A1 EIF4E SMARCA4 CCAR2 GNB1 DHX29

2.22e-0514251041530948266
Pubmed

The mouse germ-cell-specific leucine-rich repeat protein NALP14: a member of the NACHT nucleoside triphosphatase family.

NLRP14 NLRP5

2.65e-053104215590904
Pubmed

Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E.

EIF4A1 EIF4E

2.65e-053104230744688
Pubmed

NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis.

NDOR1 KMT2A

2.65e-053104227889185
Pubmed

Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint.

TPR MAD2L1

2.65e-053104218981471
Pubmed

Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis.

TPR MAD2L1

2.65e-053104224344181
Pubmed

Adenovirus-specific translation by displacement of kinase Mnk1 from cap-initiation complex eIF4F.

EIF4A1 EIF4E

2.65e-053104210880459
Pubmed

Lysine (K)-specific demethylase 5C regulates the incidence of severe preeclampsia by adjusting the expression of bone morphogenetic protein-7.

KDM5C BMPR2

2.65e-053104235331081
Pubmed

LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation.

LRRK1 CARD11

2.65e-053104227166870
Pubmed

MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1.

SMARCA4 MGA

2.65e-053104224362264
Pubmed

The complete amino acid sequence for brain beta spectrin (beta fodrin): relationship to globin sequences.

SPTAN1 SPTBN1

2.65e-05310428479293
Pubmed

Interaction of the C-terminal domain of delta glutamate receptor with spectrin in the dendritic spines of cultured Purkinje cells.

SPTAN1 SPTBN1

2.65e-053104210576550
Pubmed

Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome.

FRYL KMT2A

2.65e-053104218195096
Pubmed

Developmental expression of brain beta-spectrin isoform messenger RNAs.

SPTAN1 SPTBN1

2.65e-05310421467942
Pubmed

alpha -Catenin binds directly to spectrin and facilitates spectrin-membrane assembly in vivo.

SPTAN1 SPTBN1

2.65e-053104211069925
Pubmed

Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.

TPR DLG5 DOCK11 CDKN2AIP LATS1 STRN4 SMARCA4 CCAR2

2.76e-05399104837536630
Pubmed

HENA, heterogeneous network-based data set for Alzheimer's disease.

TRIO SPTAN1 SPTBN1 FRYL ZNF544

3.15e-05120104531413325
Pubmed

Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes.

SPTAN1 SPTBN1 GNB1

3.32e-0521104312202484
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KMT2B KDM5C KMT2A

3.32e-0521104327626377
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

SPEF2 EIF4A1 SMARCA4 KMT2A CARD11 NLRP5

3.97e-05208104633230847
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

MAP1A NUMA1 SYNGAP1 LATS1 EIF4E MGA GAREM1 PCNT

4.68e-05430104835044719
Pubmed

The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A.

EIF4A1 EIF4E

5.29e-05410428449919
Pubmed

Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.

EIF4A1 EIF4E

5.29e-05410428521827
Pubmed

Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.

NDOR1 KMT2B

5.29e-054104223826075
Pubmed

Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator.

TPR MAD2L1

5.29e-054104219273613
Pubmed

Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts.

NDOR1 LRP5

5.29e-054104229176883
Pubmed

The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.

SPTAN1 SPTBN1

5.29e-054104221566095
Pubmed

Remarkable homology among the internal repeats of erythroid and nonerythroid spectrin.

SPTAN1 SPTBN1

5.29e-05410423862089
Pubmed

A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.

KMT2B KMT2A

5.29e-054104223129768
Pubmed

Cross-talk between histone modifications in response to histone deacetylase inhibitors: MLL4 links histone H3 acetylation and histone H3K4 methylation.

KMT2B KMT2A

5.29e-054104217166833
Pubmed

Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs.

SPTBN1 SPTBN2

5.29e-054104221412925
Pubmed

Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates by cleaving TFIIA.

KMT2B KMT2A

5.29e-054104234156981
Pubmed

WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket.

KMT2B KMT2A

5.29e-054104218840606
Pubmed

Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo.

EIF4A1 EIF4E

5.29e-054104211408474
Pubmed

Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes.

KMT2B KMT2A

5.29e-054104226267306
Pubmed

Phosphorylation of a threonine unique to the short C-terminal isoform of betaII-spectrin links regulation of alpha-beta spectrin interaction to neuritogenesis.

SPTAN1 SPTBN1

5.29e-054104217088250
Pubmed

MLL1 is required for PAX7 expression and satellite cell self-renewal in mice.

KMT2B KMT2A

5.29e-054104231534153
Pubmed

Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A.

EIF4A1 EIF4E

5.29e-05410429372926
Pubmed

Brain beta spectrin isoform 235 (Spnb-2) maps to mouse chromosome 11.

SPTAN1 SPTBN1

5.29e-05410421638088
Pubmed

Loss of β2-spectrin prevents cardiomyocyte differentiation and heart development.

SPTBN1 SPTBN2

5.29e-054104224064296
Pubmed

Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site.

SPTAN1 SPTBN1

5.29e-054104212820899
Pubmed

Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory.

KMT2B KMT2A

5.29e-054104225834037
Pubmed

BMP1-like proteinases are essential to the structure and wound healing of skin.

NDOR1 LAMA2

5.29e-054104227363389
Pubmed

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.

KMT2B SMARCA4 KMT2A CCAR2 MGA

5.34e-05134104525452129
Pubmed

NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.

SPTAN1 SPTBN1 SPTBN2

5.69e-0525104330309841
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

DOCK11 SPTAN1 FRYL MAST2 LATS1 CRLF3 SNX18 STRN4

6.04e-05446104824255178
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

ZNF765 ZNF845 SPTBN1 ZNF813 SYNGAP1 ZNF320 ZNF28 ZNF655 ZNF525 ZNF468 ZNF160 MGA MAD2L1

6.30e-0512031041329180619
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

MAP1A DOCK11 SPTAN1 SEC31A PSTPIP2 ZCCHC3 EIF4E SNX18 MGA DHX29

6.46e-057241041036232890
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

KLHL6 TRIO KDM5C SPTAN1 SPTBN1 NUMA1 SMARCA4

6.52e-05332104737433992
Pubmed

Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.

SPTAN1 SPTBN1 SPTBN2 HECTD4 SYNGAP1

8.28e-05147104516959763
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

DAB2IP MAP1A SPTAN1 SPTBN1 SYNGAP1 BMPR2 STRN4

8.59e-05347104717114649
Pubmed

Evolving Catalytic Properties of the MLL Family SET Domain.

KMT2B KMT2A

8.80e-055104226320581
Pubmed

Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.

KMT2B KMT2A

8.80e-055104225561738
Pubmed

Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells.

EIF4A1 EIF4E

8.80e-055104216648488
InteractionKALRN interactions

DAB2IP SESTD1 TRIO SPTAN1 SPTBN1 SPTBN2 SYNGAP1 GNB1 PCNT

1.50e-09961039int:KALRN
InteractionTRIM28 interactions

ZNF765 ZNF845 MAP1A KDM5C SPTAN1 NUMA1 ZNF813 SEC31A VPS16 ZNF320 ZNF28 GRHPR ZNF544 ZNF655 EIF4A1 SMARCA4 ZNF888 CCAR2 ZNF761 ZNF468 GNB1 UHRF2 ZNF160 DHX29

2.92e-07147410324int:TRIM28
InteractionYWHAE interactions

DAB2IP SESTD1 DLG5 RAP1GDS1 DOCK11 SPTAN1 FRYL MAST2 FAN1 SYNGAP1 LATS1 APPL2 GRHPR KMT2A CCAR2 GNB1 MGA EFCAB7 SPATA13 GAREM1

4.83e-06125610320int:YWHAE
InteractionPRECSIT interactions

MAP1A ATG2B SNX18

1.07e-0591033int:PRECSIT
InteractionYWHAH interactions

DAB2IP DLG5 TRIO DOCK11 SPTAN1 SPTBN1 CNTRL HECTD4 FRYL MAST2 SYNGAP1 LATS1 STARD9 ZNF286B KMT2A CCAR2 SPATA13 PCNT

1.10e-05110210318int:YWHAH
InteractionAGAP2 interactions

DAB2IP MAP1A TRIO SPTAN1 SPTBN1 SPTBN2 SYNGAP1 GNB1

1.24e-052101038int:AGAP2
InteractionCNKSR2 interactions

SPTAN1 SPTBN1 SPTBN2 SYNGAP1 GNB1

2.21e-05661035int:CNKSR2
InteractionTNIK interactions

TPR TRIO DOCK11 SPTAN1 SPTBN1 SPTBN2 SYNGAP1 STRN4 CCAR2 MGA

2.57e-0538110310int:TNIK
InteractionSYNGAP1 interactions

DAB2IP STARD13 MAP1A SPTBN1 SPTBN2 SYNGAP1 GNB1 DHX29 PCNT

2.82e-053071039int:SYNGAP1
InteractionPCNT interactions

C1orf87 SPTAN1 SPTBN1 CNTRL SPTBN2 SYNGAP1 LATS1 PCNT

3.33e-052411038int:PCNT
InteractionYWHAZ interactions

DAB2IP SESTD1 DLG5 DOCK11 SPTAN1 SPTBN1 SPTBN2 HECTD4 FRYL MAST2 FAN1 SYNGAP1 LATS1 STARD9 KMT2A CCAR2 SPATA13 GAREM1 PCNT

3.51e-05131910319int:YWHAZ
InteractionDLGAP1 interactions

DAB2IP TRIO SPTAN1 SPTBN1 SPTBN2 SYNGAP1 GNB1

3.89e-051801037int:DLGAP1
InteractionDISC1 interactions

MAP1A TRIO SPTAN1 SPTBN1 FRYL VPS16 ZNF655 SNX18 GNB1 PCNT

6.96e-0542910310int:DISC1
InteractionKAT8 interactions

TPR KMT2B PHF20L1 KMT2A CCAR2

1.27e-04951035int:KAT8
InteractionKCNA3 interactions

TPR DLG5 SPEF2 SPTBN1 ATG2B NUMA1 SEC31A LATS1 EIF4A1 SMARCA4 KMT2A CARD11 DHX29 NLRP5

1.38e-0487110314int:KCNA3
InteractionPURG interactions

ZNF845 CDKN2AIP ZNF813 ZCCHC3 ZNF320 ZNF28 DDX50

1.49e-042231037int:PURG
Cytoband19q13.42

ZNF765 ZNF845 ZNF813 ZNF525 ZNF761 ZNF160

4.40e-07125104619q13.42
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZNF765 ZNF845 KMT2B ZNF813 ZNF320 ZNF28 ZNF544 STRN4 ZNF888 ZNF525 ZNF761 ZNF468 ZNF160 NLRP5

5.32e-07119210414chr19q13
Cytoband19q13.41

ZNF320 ZNF28 ZNF888 ZNF468

3.12e-0578104419q13.41
Cytoband8q24.22

DNAAF11 PHF20L1

6.76e-041710428q24.22
GeneFamilyEF-hand domain containing|Spectrins

SPTAN1 SPTBN1 SPTBN2

1.76e-0676831113
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF765 ZNF845 ZNF813 ZNF320 ZNF28 ZNF544 ZNF655 ZNF286B ZNF888 ZNF525 ZNF761 ZNF468 ZNF160

2.29e-06718681328
GeneFamilyPHD finger proteins

KMT2B KDM5C PHF20L1 KMT2A UHRF2

2.22e-059068588
GeneFamilyPyrin domain containing|Pyrin and HIN domain family

MEFV NLRP14 NLRP5

1.10e-0425683994
GeneFamilyDEAD-box helicases

DDX50 EIF4A1 DDX53

5.26e-0442683499
GeneFamilyPleckstrin homology domain containing|SH2 domain containing|C2 and RasGAP domain containing

DAB2IP SYNGAP1

6.15e-0410682830
GeneFamilyKinesins|Pleckstrin homology domain containing

STARD9 KIF4B KIF17

6.88e-0446683622
GeneFamilyZinc fingers CXXC-type

KMT2B KMT2A

8.98e-0412682136
GeneFamilyLow density lipoprotein receptors

LRP1B LRP5

1.06e-0313682634
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

DOCK11 SPTBN1 SPTBN2 APPL2 SPATA13

1.07e-03206685682
GeneFamilyStAR related lipid transfer domain containing

STARD13 STARD9

1.42e-0315682759
GeneFamilyNLR family

NLRP14 NLRP5

3.95e-0325682666
GeneFamilyCalcium voltage-gated channel subunits|Membrane associated guanylate kinases

DLG5 CARD11

4.27e-0326682904
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT2B KMT2A

7.24e-0334682487
GeneFamilyTudor domain containing

PHF20L1 UHRF2

8.53e-0337682780
CoexpressionHALLMARK_MITOTIC_SPINDLE

TRIO SPTAN1 SPTBN1 CNTRL NUMA1 LATS1 CCNB2 PCNT

1.14e-061991028M5893
CoexpressionGSE8685_IL2_ACT_IL2_STARVED_VS_IL15_ACT_IL2_STARVED_CD4_TCELL_UP

DOCK11 SPTBN1 LAMA2 APPL2 GRHPR CRLF3 CCAR2

1.36e-052001027M331
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

TRIO SPEF2 SPTAN1 SPTBN1 BMPR2 USHBP1 KMT2A PCNT

2.37e-082001048dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate|5w / Sample Type, Dataset, Time_group, and Cell type.

DLG5 TRIO SPTAN1 SPTBN1 HECTD4 KMT2A GNB1

4.56e-072001047c92e4fc0442404481fcac623d691dae6215b852d
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SNED1 USHBP1 STARD9 HSD17B13 ZNF160 IL3RA

3.88e-061781046375156ba1c7b8592bf733c75f24968161f7cfa09
ToppCell15-Distal-Immune-Hematopoietic,_B_Cells|Distal / Age, Tissue, Lineage and Cell class

KLHL6 SMIM24 PSTPIP2 SH2D4B CARD11 ALOX12

4.69e-061841046c294cd421f277992b56ae9c40b8f3948e33148fe
ToppCellIPF-Lymphoid-B|Lymphoid / Disease state, Lineage and Cell class

KLHL6 SESTD1 TRIO LRRK1 CR1 SNED1

5.15e-061871046af1327559f7e01bec070881cae52834917c3da65
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 STARD13 DOCK11 CNTRL PSTPIP2 LOXL3

6.35e-061941046c95d5c4ad0210ebd672926558cc8331e6396a854
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 STARD13 DOCK11 CNTRL PSTPIP2 LOXL3

6.74e-061961046cbc727b55b6433a701b1a331028a49960fcee6ee
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ATG2B OAS3 BMPR2

3.77e-05281043456cf2e0a6ea59c279efc77a1d02e5572196cb6b
ToppCell3'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DIRAS1 MAP1A ZCCHC3 CARD11 IL3RA

4.94e-051701045db0ec8b7ecbb4db108fc35c564df4b740f65cc8f
ToppCell3'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DIRAS1 MAP1A ZCCHC3 CARD11 IL3RA

4.94e-05170104588f6804e973863245ca1c7e5e6656d4a8b824da9
ToppCell10x5'-blood-Myeloid_Dendritic-pDC|blood / Manually curated celltypes from each tissue

MAP1A LRP5 CFAP61 KIF17 IL3RA

4.94e-05170104559cb1262ff319349d42b11afbec2a9035b7b79f2
ToppCell3'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DIRAS1 MAP1A ZCCHC3 CARD11 IL3RA

4.94e-051701045dad3aaf7d9f7bafdbddee51610f03f2359e587ae
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

STARD13 MAP1A HECTD4 BMPR2 LOXL3

5.66e-0517510451d8aab491dcc27ea5dbfb6462d18ee280b21a05e
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

STARD13 MAP1A HECTD4 BMPR2 LOXL3

5.66e-051751045427a7ee92fe16a90625946492062d37aa0f7235b
ToppCell10x3'2.3-week_12-13-Myeloid_DC-DC-pDC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

MAP1A AQP7B CARD11 KIF17 IL3RA

5.98e-051771045e36c2005be74ee8ff03c2052504cb496faf86009
ToppCelldroplet-Liver-LIVER_HEP-30m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAB2IP SPTBN1 BMPR2 USHBP1 KMT2A

6.47e-051801045dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCelldroplet-Liver-LIVER_HEP|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAB2IP SPTBN1 BMPR2 USHBP1 KMT2A

6.47e-051801045423454e3390080ae03bb3cbb267255ebfe4df080
ToppCellhealthy_donor-Myeloid-Monocytic-SC_&_Eosinophil|healthy_donor / Disease condition, Lineage, Cell class and subclass

SMIM24 DIRAS1 MAP1A SPTBN2 IL3RA

6.82e-0518210456bd6c32c48fecd6d03ac8a09e405b3b99bdc12ae
ToppCellB_cells-ABCs|B_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

DOCK11 OAS3 CCNB2 MAD2L1 SPATA13

7.00e-051831045bf9c6fe3ce4e44e4056027257eab8448c39c4fb8
ToppCell10x5'-bone_marrow-Myeloid_Dendritic-Cycling_Dendritic|bone_marrow / Manually curated celltypes from each tissue

MAP1A CCNB2 KIF17 IL3RA MAD2L1

7.37e-0518510459d3168c7f0b1d739f78b368969cf5c77ce202b97
ToppCelltumor_Lung-Epithelial_cells-tS3|Epithelial_cells / Location, Cell class and cell subclass

MAP1A C1orf87 SPEF2 DNAAF11 CFAP61

7.75e-0518710453cea677279e71fdb9879530dea10a5e6393beacd
ToppCellControl-Lymphoid-B|Lymphoid / Disease state, Lineage and Cell class

SESTD1 TRIO LRRK1 CR1 SNED1

7.75e-0518710454e64be635f445276e71f2937f33f041c3a4204ab
ToppCell368C-Lymphocytic-NK_cells-Proliferating_NK_cell|368C / Donor, Lineage, Cell class and subclass (all cells)

SPEF2 ZNF525 CARD11 ZNF468 MAD2L1

8.15e-05189104531d34bc75d4457fca197e1766922e987dbd5f8a9
ToppCell(0)_Myeloid-(01)_Dendritic_cell|(0)_Myeloid / immune cells in Peripheral Blood (logTPM normalization)

MAP1A ZNF888 CARD11 KIF17 IL3RA

8.35e-051901045e9507bb0c8ff3d071402731a9b8cfe1bba93fab0
ToppCellCOPD-Lymphoid-B|Lymphoid / Disease state, Lineage and Cell class

KLHL6 SESTD1 TRIO LRRK1 SNED1

8.35e-0519010451e85ee686ff6dd27c69415d524d54fa825b1daad
ToppCell10x5'v1-week_14-16-Myeloid_DC-DC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MAP1A LRP1B CARD11 KIF17 IL3RA

8.35e-051901045d06800ec9f6065c1cc536ed99e8569732272a94f
ToppCell10x5'v1-week_14-16-Myeloid_DC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MAP1A LRP1B CARD11 KIF17 IL3RA

8.35e-051901045485073e831afebdb393c7f4b622504d43d1b778b
ToppCell(04)_Pre-ciliated|World / shred by cell type and Timepoint

SMIM24 MAP1A MAST2 POC5 PCNT

8.56e-05191104537cf121e6e80760c8519075b7845b9029958a988
ToppCellControl-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

C1orf87 SPEF2 DNAAF11 CFAP61 SPATA13

8.99e-0519310450e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCellwk_08-11-Hematologic-Meg-ery-Definitive_erythroblast|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ATG2B HECTD4 LRRC2 CR1 PCNT

8.99e-051931045be75abfdf5301cf33df8ee9ed92504d44fdf19a6
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CNTRL KMT2A CARD11 POC5 UHRF2

9.44e-0519510454b9663509cc5e3f409f6d0d37640cb301a827d98
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 DOCK11 CNTRL PSTPIP2 CARD11

9.44e-0519510457b6c69df943842b566a596e30bb50dbe80dccc83
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

KLHL6 MAP1A C1orf87 SPEF2 DNAAF11

9.44e-0519510453486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCellNS-control-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KLHL6 MAP1A C1orf87 SPEF2 DNAAF11

9.67e-051961045d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCellmyeloid-pro-pDC|myeloid / Lineage and Cell class

MAP1A CARD11 KIF17 IL3RA MAD2L1

9.67e-05196104570daf4fabb68aecc5cc9f03d6f6495dd29b74a16
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 DOCK11 CNTRL PSTPIP2 LOXL3

9.90e-0519710456ca6e17b7cc5f7ea8d4b6ca1ff670969bee65a45
ToppCellmild-pDC|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MAP1A LRRK1 LRP5 KIF17 IL3RA

9.90e-0519710450cb00daa6943f7a7fb34a8fdf51188646af65686
ToppCellcritical-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

MAP1A C1orf87 SPEF2 CNTRL DNAAF11

1.01e-041981045ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SPTAN1 SPTBN1 OAS3 BMPR2 USHBP1

1.06e-042001045bcd1cc96197929d6011903803b6f4ccdcf52b4ce
ToppCellLPS_only-Endothelial-Endothelial-Gen_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

SPTAN1 SPTBN1 OAS3 BMPR2 USHBP1

1.06e-042001045eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

SPTAN1 SPTBN1 OAS3 BMPR2 KMT2A

1.06e-042001045edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SPTAN1 SPTBN1 OAS3 BMPR2 USHBP1

1.06e-04200104589821a264e872ed53e08e9d3609d5cc5c314503e
ToppCellControl_saline-Endothelial-Endothelial-Gen_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

SPEF2 SPTAN1 SPTBN1 BMPR2 USHBP1

1.06e-0420010453b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCellLPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS_only / Treatment groups by lineage, cell group, cell type

SPTAN1 SPTBN1 OAS3 BMPR2 USHBP1

1.06e-042001045b1fadb2b5e37e0f51e079d8409c2647eef68dc3b
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Gen_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SPEF2 SPTAN1 SPTBN1 BMPR2 USHBP1

1.06e-042001045a2b9d1cd291d17abddc3ee2e242121412c864b8b
DrugBetaxolol hydrochloride [63659-19-8]; Down 200; 11.6uM; HL60; HG-U133A

TPR RAP1GDS1 CDKN2AIP NUMA1 FRYL MAST2 KMT2A MGA

3.34e-0620010281592_DN
Diseasespinocerebellar ataxia type 5 (implicated_via_orthology)

SPTBN1 SPTBN2

6.66e-054992DOID:0050882 (implicated_via_orthology)
Diseasemyocardial infarction

DAB2IP CDKN2AIP HECTD4 OAS3 SNX18 SMARCA4 MAD2L1

1.82e-04350997EFO_0000612
DiseaseWriter's Cramp

KMT2B GNAL

2.31e-047992C4316810
DiseaseDystonia Disorders

KMT2B GNAL

2.31e-047992C0393593
DiseaseIdiopathic familial dystonia

KMT2B GNAL

2.31e-047992C0393598
DiseaseAdult-Onset Idiopathic Focal Dystonias

KMT2B GNAL

2.31e-047992C0752198
DiseaseAdult-Onset Dystonias

KMT2B GNAL

2.31e-047992C0752197
DiseaseAdult-Onset Idiopathic Torsion Dystonias

KMT2B GNAL

2.31e-047992C0752199
DiseaseAutosomal Dominant Familial Dystonia

KMT2B GNAL

2.31e-047992C0752200
DiseaseChildhood Onset Dystonias

KMT2B GNAL

2.31e-047992C0752202
DiseaseAutosomal Recessive Familial Dystonia

KMT2B GNAL

2.31e-047992C0752201
DiseaseDystonia, Primary

KMT2B GNAL

2.31e-047992C0752203
DiseaseDystonias, Sporadic

KMT2B GNAL

2.31e-047992C0752206
DiseaseDystonia, Secondary

KMT2B GNAL

2.31e-047992C0752205
DiseasePseudodystonia

KMT2B GNAL

2.31e-047992C0752208
DiseaseFamilial Dystonia

KMT2B GNAL

2.31e-047992C0752207
DiseaseFocal Dystonia

KMT2B GNAL

2.31e-047992C0743332
DiseaseDevelopmental delay (disorder)

KDM5C SPTBN2 GNB1

2.62e-0437993C0424605
Diseasevascular endothelial function measurement

ZNF765 ZNF28 ZNF761 ZNF468

3.52e-0499994EFO_0803369
Diseasevon Willebrand factor measurement, coronary artery disease

DAB2IP HECTD4 SMARCA4 MAD2L1

6.83e-04118994EFO_0001645, EFO_0004629
Diseasealcohol consumption measurement, alcohol drinking

HECTD4 OAS3

7.20e-0412992EFO_0004329, EFO_0007878
DiseasePapillary Renal Cell Carcinoma

ZNF765 KDM5C LRP1B CARD11

9.25e-04128994C1306837
DiseaseRenal Cell Carcinoma

ZNF765 KDM5C LRP1B CARD11

9.25e-04128994C0007134
DiseaseSarcomatoid Renal Cell Carcinoma

ZNF765 KDM5C LRP1B CARD11

9.25e-04128994C1266043
DiseaseChromophobe Renal Cell Carcinoma

ZNF765 KDM5C LRP1B CARD11

9.25e-04128994C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

ZNF765 KDM5C LRP1B CARD11

9.25e-04128994C1266044
Diseaseperiodontitis

DAB2IP FAM47A LAMA2 LRP1B UHRF2

9.47e-04223995EFO_0000649
Diseasedystonia (is_implicated_in)

KMT2B VPS16

9.88e-0414992DOID:543 (is_implicated_in)
Diseaseautosomal dominant polycystic kidney disease (implicated_via_orthology)

LATS1 LRP5

9.88e-0414992DOID:898 (implicated_via_orthology)
Diseaseteratocarcinoma-derived growth factor 1 measurement

LRRC2 KMT2A

1.30e-0316992EFO_0008297
Diseasemyopia (is_implicated_in)

LAMA2 LOXL3

1.30e-0316992DOID:11830 (is_implicated_in)
DiseaseDystonia, Limb

KMT2B GNAL

1.47e-0317992C0751093
Diseaseesophageal carcinoma, gastric carcinoma

ATG2B MAST2

1.47e-0317992EFO_0000178, EFO_0002916
DiseaseDystonia, Diurnal

KMT2B GNAL

1.47e-0317992C0393610
Diseaseautosomal dominant intellectual developmental disorder (is_implicated_in)

KMT2B TRIO

1.47e-0317992DOID:0060307 (is_implicated_in)
Diseasefactor XI measurement, Ischemic stroke

HECTD4 ZNF160

1.47e-0317992EFO_0004694, HP_0002140
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

ZNF765 KDM5C LRP1B CARD11

1.58e-03148994C0279702
DiseaseMyeloid Leukemia

ATG2B KMT2A

1.65e-0318992C0023470
DiseaseDystonia, Paroxysmal

KMT2B GNAL

1.65e-0318992C0393588
DiseaseLeukemia, Monocytic, Chronic

ATG2B KMT2A

1.65e-0318992C0023466
Diseasefibrinogen measurement, coronary artery disease

CDKN2AIP HECTD4 SMARCA4 MAD2L1

1.83e-03154994EFO_0001645, EFO_0004623
DiseaseHereditary Non-Polyposis Colon Cancer Type 2

FAN1 SMARCA4

1.84e-0319992C1333991
DiseaseColorectal cancer, hereditary nonpolyposis, type 1

FAN1 SMARCA4

1.84e-0319992C2936783
Diseaseprostate cancer (is_marker_for)

KMT2B SMARCA4 KMT2A ALOX12

1.92e-03156994DOID:10283 (is_marker_for)
DiseaseSchizophrenia

SPTBN2 LAMA2 SYNGAP1 KMT2A GNAL KIF17 IL3RA ALOX12 PCNT

2.90e-03883999C0036341

Protein segments in the cluster

PeptideGeneStartEntry
AEKEAWRLLAQEEAA

USHBP1

381

Q8N6Y0
LEEWEALCQQKAAEA

CCAR2

436

Q8N163
EEDCFKALIWIRNNS

CFAP61

816

Q8NHU2
LQEEERWCESLEKTL

CNTRL

2006

Q7Z7A1
VFEAVLNWAEAECKR

BTBD6

301

Q96KE9
EDLLLNEWEASKCNI

DHX29

611

Q7Z478
WDINKRGVEETAAEC

HSD17B13

66

Q7Z5P4
LDKWCLNEILESADA

ATG2B

51

Q96BY7
NKAEECETWIDRFRK

C1orf87

466

Q8N0U7
VREEWQSEHIKACEA

PSTPIP2

201

Q9H939
DIFKLAEANACWALE

OTOA

836

Q7RTW8
RELKEVFASWRQECS

DAB2IP

491

Q5VWQ8
WKDVVERACQARAEE

POC5

296

Q8NA72
RHDIDCQWIDITDVK

LOXL3

671

P58215
RDEKNEVIATVLCWD

KLHL6

566

Q8WZ60
WCDARTDKIERIDLE

LRP1B

2056

Q9NZR2
KAENEEAAACPAWER

MAP1A

2376

P78559
VLERWQFDIECDKTA

MAD2L1

96

Q13257
IEIISDCNWEEDRNK

MGA

1336

Q8IWI9
KAERDILAEADNEWV

LATS1

751

O95835
RGEEVVWCLDDKANS

LRRK1

1746

Q38SD2
VIAKIQEIWCEEDER

AQP7B

21

A0A075B734
LFWVDADLKRIESCD

LRP5

1126

O75197
DKIAIWTTECENREA

EIF4E

161

P06730
AAWVEALRCDGETDK

CDKN2AIP

16

Q9NXV6
INVEREEWKLDTLCD

EIF4A1

251

P60842
IVRWCKVDDDFTAQD

CRLF3

196

Q8IUI8
RAVRDVKTDWNEECK

GAREM1

341

Q9H706
VKREAAEQWLDDCKR

FRYL

2791

O94915
ERKLEDAWARCEARE

FAM47B

156

Q8NA70
DAWARCEAREKTTEV

FAM47B

161

Q8NA70
EALQEADVAKCRRDW

DLG5

511

Q8TDM6
EKIKEEWNFVAECRR

LRRC2

41

Q9BYS8
NKVDDAWDLLREATD

LAMA2

1781

P24043
VRVDFKEDCDLENVW

KMT2B

1171

Q9UMN6
RDKTLIEEQWEDFCS

NLRP5

761

P59047
LEAKECQSEWELLQD

MEFV

516

O15553
KSALAEKVRQCWQDD

ALOX12

211

P18054
AFQVLANRCVEWEKE

HECTD4

1326

Q9Y4D8
LKEDWESEKDLCLEN

PCNT

346

O95613
EAEWQELEKRDCLTL

NDOR1

496

Q9UHB4
WDDEGVKACFERSNE

GNAL

141

P38405
DERRKWIQCFNDVTA

GNAL

216

P38405
DTREAQAVAQEWKCA

DIRAS1

131

O95057
WDLNRNVTDIECVKD

IL3RA

41

P26951
KWEDVNAAACDLARE

BHMT2

86

Q9H2M3
AESRRQCNVDIKWVD

DOCK11

791

Q5JSL3
DALLCKIEDIDNEDW

CCNB2

111

O95067
ENLVWSSVEDNCRRK

CR1

1441

P17927
DFNCNVWDALKADRA

GNB1

291

P62873
DEDAWAVCRENFDTK

EFCAB7

441

A8K855
VALARAADCEVEQWD

GRHPR

21

Q9UBQ7
LVERLVEWCEAKDHA

RAP1GDS1

446

P52306
LKETIEDCWDQDAEA

BMPR2

476

Q13873
EEIQDVSCAWKELNR

DDX50

596

Q9BQ39
QAESRKENEEWICAI

APPL2

356

Q8NEU8
QEIERLEHIDKWCRD

DNAAF11

31

Q86X45
LWESECAQAVKEDPA

MAST2

1726

Q6P0Q8
KHLDPERELEDAWAC

FAM47A

151

Q5JRC9
LLDAESEDRPKQCWE

KIF4B

841

Q2VIQ3
IRVDFKEDCEAENVW

KMT2A

1401

Q03164
SNWDRIRAAVVECEK

DDX53

151

Q86TM3
KDEEDALWENVECNR

CARD11

16

Q9BXL7
TAEDLDWEKEAAFQC

POM121L1P

226

Q3SYA9
SECEQLVKEVAAWRE

NUMA1

801

Q14980
NARWDLLAKEAAACT

OAS3

1051

Q9Y6K5
DFKAGEEVLARWTDC

PHF20L1

86

A8MW92
NLEKILRESCWDEDN

KIF17

876

Q9P2E2
EAKELAQCAKRDWNR

FAN1

626

Q9Y2M0
LWDICDARKEEAEQE

SPEF2

1116

Q9C093
QEIEAKEACDWLRAA

STARD13

56

Q9Y3M8
WIIKDDAEVERLTCE

SMARCA4

1346

P51532
ANRLWCSKARAEDEE

SMIM24

51

O75264
LWKERRALEEQCDED

STARD9

621

Q9P2P6
KDRCVVAAFWADVDN

SNED1

96

Q8TER0
KCEEDAAQAVEWLSE

SESTD1

501

Q86VW0
SEADACELWIDEKEQ

SPTBN1

856

Q01082
ENEVLEAWKSLLDAC

SPTBN1

1886

Q01082
RDVAIEFSQEEWKCL

ZNF845

11

Q96IR2
RDVAIEFSQEEWKCL

ZNF525

11

Q8N782
QEDKARWLQACADER

SPATA13

546

Q96N96
REDCQNQKLWDEVLS

UHRF2

701

Q96PU4
RDVAIEFSQEEWKCL

ZNF761

11

Q86XN6
RDVAIEFSQEEWKCL

ZNF160

11

Q9HCG1
RDVAIEFSQEEWKCL

ZNF320

11

A2RRD8
EKREQEDCWENFVVL

ZCCHC3

231

Q9NUD5
SAVAWEERFCALEKL

SPTBN2

2061

O15020
FACRSAAERDKWIEN

SYNGAP1

231

Q96PV0
ESQLLECKASWEERE

TPR

1121

P12270
RDVDAWVFSLECKLD

SNX18

581

Q96RF0
EDAVKARLAALADQW

SPTAN1

1626

Q13813
DWDLKEELRDCLVAA

VPS16

26

Q9H269
DLAAKAQVWLEQVCA

NAPRT

241

Q6XQN6
RDVAIEFSQEEWKCL

ZNF813

11

Q6ZN06
RDVAIEFSQEEWKCL

ZNF888

11

P0CJ79
EVLTRQKAFDCDVWE

ZNF655

456

Q8N720
DLCRAEQEAPRDWKA

ZNF544

71

Q6NX49
RDVAIEFSQEEWKCL

ZNF28

11

P17035
RDVAIEFSQEEWKCL

ZNF765

11

Q7L2R6
AQLHCQASEKEEREW

SH2D4B

196

Q5SQS7
AEKARWEAERAELQA

STRN4

81

Q9NRL3
FSKWERQCLAEAEQD

TAPR1

21

Q14CZ0
SNLEAALECENWLEK

ZNF286B

151

P0CG31
VESCDLKNWREALAA

SEC31A

641

O94979
RDVAIEFSQEEWKCL

ZNF468

11

Q5VIY5
LEQEWKAFAAALDER

TRIO

426

O75962
ERWEEKAHLCLEARQ

KDM5C

981

P41229
DLCERAKEEINWSAQ

NLRP14

86

Q86W24