Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmetalloendopeptidase activity

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2 ADAMTSL2

1.12e-09120347GO:0004222
GeneOntologyMolecularFunctionmetallopeptidase activity

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2 ADAMTSL2

3.89e-08200347GO:0008237
GeneOntologyMolecularFunctionendopeptidase activity

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2 ADAMTSL2

6.65e-06430347GO:0004175
GeneOntologyMolecularFunctionheparin binding

ADAMTS15 PTN RSPO3 THBS2 ADAMTS3

1.73e-05192345GO:0008201
GeneOntologyMolecularFunctionglycosaminoglycan binding

ADAMTS15 PTN RSPO3 THBS2 ADAMTS3

8.49e-05268345GO:0005539
GeneOntologyMolecularFunctionpeptidase activity

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2 ADAMTSL2

9.74e-05654347GO:0008233
GeneOntologyMolecularFunctionsulfur compound binding

ADAMTS15 PTN RSPO3 THBS2 ADAMTS3

2.03e-04323345GO:1901681
GeneOntologyMolecularFunctionextracellular matrix structural constituent

DPT THBS2 SSPOP MUC6

2.83e-04188344GO:0005201
GeneOntologyMolecularFunctionoxysterol binding

INSIG2 INSIG1

3.33e-0416342GO:0008142
GeneOntologyMolecularFunctionprotein sequestering activity

INSIG2 INSIG1

1.53e-0334342GO:0140311
GeneOntologyBiologicalProcessextracellular matrix organization

ADAMTS12 ADAMTS15 ADAMTS20 DPT ADAMTS14 ADAMTS3 ADAMTS2 ADAMTSL2

1.08e-07377338GO:0030198
GeneOntologyBiologicalProcessextracellular structure organization

ADAMTS12 ADAMTS15 ADAMTS20 DPT ADAMTS14 ADAMTS3 ADAMTS2 ADAMTSL2

1.10e-07378338GO:0043062
GeneOntologyBiologicalProcessexternal encapsulating structure organization

ADAMTS12 ADAMTS15 ADAMTS20 DPT ADAMTS14 ADAMTS3 ADAMTS2 ADAMTSL2

1.12e-07379338GO:0045229
GeneOntologyBiologicalProcesscollagen fibril organization

ADAMTS12 DPT ADAMTS14 ADAMTS3 ADAMTS2

1.30e-0776335GO:0030199
GeneOntologyBiologicalProcessSREBP-SCAP complex retention in endoplasmic reticulum

INSIG2 INSIG1

2.48e-062332GO:0036316
GeneOntologyBiologicalProcessnegative regulation of SREBP signaling pathway

INSIG2 INSIG1

7.44e-063332GO:2000639
GeneOntologyBiologicalProcessregulation of SREBP signaling pathway

INSIG2 INSIG1

6.91e-058332GO:2000638
GeneOntologyBiologicalProcesscollagen catabolic process

ADAMTS14 ADAMTS3 ADAMTS2

8.28e-0553333GO:0030574
GeneOntologyBiologicalProcesscranial suture morphogenesis

INSIG2 INSIG1

1.11e-0410332GO:0060363
GeneOntologyBiologicalProcessmaintenance of protein localization in endoplasmic reticulum

INSIG2 INSIG1

2.57e-0415332GO:0035437
GeneOntologyBiologicalProcessSREBP signaling pathway

INSIG2 INSIG1

2.94e-0416332GO:0032933
GeneOntologyBiologicalProcesscellular response to sterol depletion

INSIG2 INSIG1

3.33e-0417332GO:0071501
GeneOntologyBiologicalProcessresponse to sterol depletion

INSIG2 INSIG1

4.17e-0419332GO:0006991
GeneOntologyBiologicalProcesscraniofacial suture morphogenesis

INSIG2 INSIG1

4.63e-0420332GO:0097094
GeneOntologyBiologicalProcessmiddle ear morphogenesis

INSIG2 INSIG1

7.88e-0426332GO:0042474
GeneOntologyBiologicalProcesscellular response to sterol

INSIG2 INSIG1

7.88e-0426332GO:0036315
GeneOntologyBiologicalProcessbone development

ADAMTS12 INSIG2 RYR1 INSIG1

8.02e-04264334GO:0060348
GeneOntologyBiologicalProcessossification involved in bone maturation

ADAMTS12 RYR1

1.05e-0330332GO:0043931
GeneOntologyBiologicalProcessregulation of cellular response to vascular endothelial growth factor stimulus

ADAMTS12 ADAMTS3

1.19e-0332332GO:1902547
GeneOntologyBiologicalProcessnegative regulation of steroid biosynthetic process

INSIG2 INSIG1

1.19e-0332332GO:0010894
GeneOntologyBiologicalProcessbone maturation

ADAMTS12 RYR1

1.27e-0333332GO:0070977
GeneOntologyBiologicalProcesstube development

ADAMTS12 PTN RSPO3 THBS2 THSD7A ADAMTS2 ADAMTSL2 ADGRB1

1.34e-031402338GO:0035295
GeneOntologyBiologicalProcessresponse to sterol

INSIG2 INSIG1

1.35e-0334332GO:0036314
GeneOntologyBiologicalProcessnegative regulation of steroid metabolic process

INSIG2 INSIG1

1.51e-0336332GO:0045939
GeneOntologyBiologicalProcessanimal organ maturation

ADAMTS12 RYR1

1.60e-0337332GO:0048799
GeneOntologyBiologicalProcesscollagen metabolic process

ADAMTS14 ADAMTS3 ADAMTS2

1.69e-03148333GO:0032963
GeneOntologyCellularComponentextracellular matrix

ADAMTS12 ADAMTS15 PTN ADAMTS20 DPT THBS2 MUC5B ADAMTS14 ADAMTS3 ADAMTS2 SSPOP MUC6 ADAMTSL2

1.99e-116563513GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

ADAMTS12 ADAMTS15 PTN ADAMTS20 DPT THBS2 MUC5B ADAMTS14 ADAMTS3 ADAMTS2 SSPOP MUC6 ADAMTSL2

2.07e-116583513GO:0030312
GeneOntologyCellularComponentcollagen-containing extracellular matrix

ADAMTS15 PTN ADAMTS20 DPT THBS2 ADAMTS3 ADAMTS2 SSPOP

2.09e-06530358GO:0062023
GeneOntologyCellularComponentSREBP-SCAP-Insig complex

INSIG2 INSIG1

8.16e-063352GO:0032937
GeneOntologyCellularComponentneuromuscular junction

PTN DLG3 KCNC4

8.65e-04112353GO:0031594
GeneOntologyCellularComponentendoplasmic reticulum protein-containing complex

INSIG2 RYR1 INSIG1

1.19e-03125353GO:0140534
MousePhenoabnormal cutaneous collagen fibril morphology

DPT THBS2 ADAMTS2

2.27e-0527293MP:0008438
MousePhenoabnormal skin tensile strength

DPT THBS2 ADAMTS2

3.82e-0532293MP:0005275
MousePhenoabnormal tendon collagen fibril morphology

THBS2 ADAMTS2

8.67e-057292MP:0011643
DomainTSP_1

ADAMTS12 ADAMTS15 RSPO3 ADAMTS20 THBS2 ADAMTS14 THSD7A ADAMTS3 ADAMTS2 SSPOP UNC5D ADAMTSL2 ADGRB1

1.71e-24633413PF00090
DomainTSP1

ADAMTS12 ADAMTS15 RSPO3 ADAMTS20 THBS2 ADAMTS14 THSD7A ADAMTS3 ADAMTS2 SSPOP UNC5D ADAMTSL2 ADGRB1

2.68e-24653413SM00209
DomainTSP1_rpt

ADAMTS12 ADAMTS15 RSPO3 ADAMTS20 THBS2 ADAMTS14 THSD7A ADAMTS3 ADAMTS2 SSPOP UNC5D ADAMTSL2 ADGRB1

2.68e-24653413IPR000884
DomainTSP1

ADAMTS12 ADAMTS15 RSPO3 ADAMTS20 THBS2 ADAMTS14 THSD7A ADAMTS3 ADAMTS2 SSPOP UNC5D ADAMTSL2 ADGRB1

2.68e-24653413PS50092
DomainADAM_spacer1

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2 ADAMTSL2

8.23e-1523347IPR010294
DomainADAM_spacer1

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2 ADAMTSL2

8.23e-1523347PF05986
DomainPeptidase_M12B_ADAM-TS

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2 ADAMTSL2

1.16e-1424347IPR013273
DomainPeptidase_M12B_N

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2

7.14e-1139346IPR002870
DomainPep_M12B_propep

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2

7.14e-1139346PF01562
DomainDISINTEGRIN_1

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2

8.39e-1140346PS00427
DomainADAM_MEPRO

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2

8.39e-1140346PS50215
DomainDISINTEGRIN_2

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2

8.39e-1140346PS50214
DomainReprolysin

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2

8.39e-1140346PF01421
DomainPeptidase_M12B

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2

8.39e-1140346IPR001590
DomainDisintegrin_dom

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2

9.81e-1141346IPR001762
DomainPLAC

ADAMTS12 ADAMTS14 ADAMTS3 ADAMTS2 ADAMTSL2

1.68e-1019345IPR010909
DomainPLAC

ADAMTS12 ADAMTS14 ADAMTS3 ADAMTS2 ADAMTSL2

1.68e-1019345PS50900
DomainMetalloPept_cat_dom

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2

6.73e-0981346IPR024079
Domain-

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2

6.73e-09813463.40.390.10
DomainZINC_PROTEASE

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2

2.13e-0898346PS00142
DomainVWF_dom

THBS2 MUC5B SSPOP MUC6

9.75e-0742344IPR001007
DomainTIL

MUC5B SSPOP MUC6

1.20e-0612343PF01826
DomainC8

MUC5B SSPOP MUC6

1.20e-0612343PF08742
DomainUnchr_dom_Cys-rich

MUC5B SSPOP MUC6

1.56e-0613343IPR014853
DomainC8

MUC5B SSPOP MUC6

1.56e-0613343SM00832
DomainTIL_dom

MUC5B SSPOP MUC6

1.98e-0614343IPR002919
DomainVWFD

MUC5B SSPOP MUC6

3.04e-0616343PS51233
DomainVWD

MUC5B SSPOP MUC6

3.04e-0616343SM00216
DomainVWF_type-D

MUC5B SSPOP MUC6

3.04e-0616343IPR001846
DomainVWD

MUC5B SSPOP MUC6

3.04e-0616343PF00094
DomainINSIG-1

INSIG2 INSIG1

3.22e-062342IPR009904
DomainINSIG_fam

INSIG2 INSIG1

3.22e-062342IPR025929
DomainINSIG

INSIG2 INSIG1

3.22e-062342PF07281
DomainVWC_out

MUC5B SSPOP MUC6

5.24e-0619343SM00215
DomainCys_knot_C

MUC5B SSPOP MUC6

1.23e-0525343IPR006207
DomainCTCK_2

MUC5B SSPOP MUC6

1.23e-0525343PS01225
DomainVWFC_1

THBS2 MUC5B SSPOP

3.78e-0536343PS01208
DomainVWC

THBS2 MUC5B SSPOP

4.45e-0538343SM00214
DomainVWFC_2

THBS2 MUC5B SSPOP

4.45e-0538343PS50184
DomainCYSTEINE_SWITCH

ADAMTS12 ADAMTS15 ADAMTS14

5.60e-0541343PS00546
DomainPept_M10_metallopeptidase

ADAMTS12 ADAMTS15 ADAMTS14

6.47e-0543343IPR001818
DomainCTCK_1

MUC5B SSPOP

4.83e-0418342PS01185
DomainCT

MUC5B MUC6

7.26e-0422342SM00041
DomainADAM_Cys-rich

ADAMTS15 ADAMTS14

1.10e-0327342IPR006586
DomainACR

ADAMTS15 ADAMTS14

1.10e-0327342SM00608
DomainVWC

THBS2 MUC5B

1.18e-0328342PF00093
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS12 ADAMTS15 ADAMTS20 THBS2 MUC5B ADAMTS14 THSD7A ADAMTS3 ADAMTS2 SSPOP MUC6 ADAMTSL2

2.77e-21682912M27303
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS12 ADAMTS15 ADAMTS20 THBS2 ADAMTS14 THSD7A ADAMTS3 ADAMTS2 SSPOP ADAMTSL2

1.44e-19392910MM15165
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS12 ADAMTS15 ADAMTS20 THBS2 ADAMTS14 THSD7A ADAMTS3 ADAMTS2 SSPOP ADAMTSL2

1.44e-19392910M27417
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS12 ADAMTS15 ADAMTS20 THBS2 MUC5B ADAMTS14 THSD7A ADAMTS3 ADAMTS2 SSPOP MUC6 ADAMTSL2

1.14e-181092912MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS12 ADAMTS15 ADAMTS20 THBS2 MUC5B ADAMTS14 THSD7A ADAMTS3 ADAMTS2 SSPOP MUC6 ADAMTSL2

1.43e-181112912M27416
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTS12 ADAMTS15 ADAMTS20 THBS2 MUC5B ADAMTS14 THSD7A ADAMTS3 ADAMTS2 SSPOP MUC6 ADAMTSL2

3.33e-171432912M27275
PathwayREACTOME_DISEASES_OF_METABOLISM

ADAMTS12 ADAMTS15 ADAMTS20 THBS2 MUC5B ADAMTS14 THSD7A ADAMTS3 ADAMTS2 SSPOP MUC6 ADAMTSL2

2.95e-142502912M27554
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

ADAMTS12 ADAMTS15 ADAMTS20 THBS2 MUC5B ADAMTS14 THSD7A ADAMTS3 ADAMTS2 SSPOP MUC6 ADAMTSL2

8.40e-0613892912MM15307
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

ADAMTS12 ADAMTS15 ADAMTS20 THBS2 MUC5B ADAMTS14 THSD7A ADAMTS3 ADAMTS2 SSPOP MUC6 ADAMTSL2

1.56e-0514752912M19806
PathwayREACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES

ADAMTS14 ADAMTS3 ADAMTS2

2.60e-0461293MM14637
PathwayREACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES

ADAMTS14 ADAMTS3 ADAMTS2

3.43e-0467293M26999
PathwayREACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC

MUC5B MUC6

4.82e-0416292M27410
PathwayREACTOME_COLLAGEN_FORMATION

ADAMTS14 ADAMTS3 ADAMTS2

4.97e-0476293MM14573
PathwayREACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS

MUC5B MUC6

5.45e-0417292M27412
PathwayREACTOME_COLLAGEN_FORMATION

ADAMTS14 ADAMTS3 ADAMTS2

8.15e-0490293M631
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC5B MUC6

8.38e-0421292MM15706
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC5B MUC6

1.01e-0323292M556
PathwayREACTOME_DECTIN_2_FAMILY

MUC5B MUC6

1.29e-0326292M27483
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

ADAMTS14 ADAMTS3 ADAMTS2 ICAM5

1.82e-03258294MM14572
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

ADAMTS14 ADAMTS3 ADAMTS2 ICAM5

3.14e-03300294M610
PathwayWP_15Q25_COPY_NUMBER_VARIATION

ZNF592 RYR1

4.00e-0346292M48105
PathwayREACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF

INSIG2 INSIG1

5.67e-0355292M27001
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTS12 ADAMTS15 ADAMTS20 THBS2 ADAMTS14 THSD7A ADAMTS3 ADAMTS2 SSPOP ADAMTSL2 ADGRB1

8.71e-2275351120637190
Pubmed

The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology.

ADAMTS14 ADAMTS3 ADAMTS2

9.34e-10335325863161
Pubmed

Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3.

ADAMTS14 ADAMTS3 ADAMTS2

9.34e-10335311741898
Pubmed

Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina.

ADAMTS14 ADAMTS3 ADAMTS2

3.73e-09435322205175
Pubmed

Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis.

ADAMTS14 ADAMTS3 ADAMTS2

1.86e-08635316556917
Pubmed

ADAMTS: a novel family of extracellular matrix proteases.

ADAMTS12 ADAMTS3 ADAMTS2

1.11e-071035311167130
Pubmed

Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.

ADAMTS12 ADAMTS20 ADAMTS2

2.04e-071235325770910
Pubmed

ADAMTS2 promotes radial migration by activating TGF-β signaling in the developing neocortex.

ADAMTS14 ADAMTS3 ADAMTS2

4.21e-071535338871984
Pubmed

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.

ADAMTS20 DPT ADAMTS3 SSPOP

5.23e-076435422261194
Pubmed

Intramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells.

INSIG2 INSIG1

9.84e-07235219617589
Pubmed

Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin.

INSIG2 INSIG1

9.84e-07235220090767
Pubmed

Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells.

INSIG2 INSIG1

9.84e-07235219638338
Pubmed

Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin.

INSIG2 INSIG1

9.84e-07235216955138
Pubmed

Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function.

ADAMTS14 ADAMTS2

9.84e-07235237929635
Pubmed

Gene-gene interactions of the INSIG1 and INSIG2 in metabolic syndrome in schizophrenic patients treated with atypical antipsychotics.

INSIG2 INSIG1

9.84e-07235220877301
Pubmed

Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis.

INSIG2 INSIG1

9.84e-07235212624180
Pubmed

Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathway.

INSIG2 INSIG1

9.84e-07235219360322
Pubmed

The INSIG1 gene, not the INSIG2 gene, associated with coronary heart disease: tagSNPs and haplotype-based association study. The Beijing Atherosclerosis Study.

INSIG2 INSIG1

9.84e-07235218989534
Pubmed

ADAMTS2 and ADAMTS14 can substitute for ADAMTS3 in adults for pro-VEGFC activation and lymphatic homeostasis.

ADAMTS14 ADAMTS2

9.84e-07235235316211
Pubmed

Insig proteins mediate feedback inhibition of cholesterol synthesis in the intestine.

INSIG2 INSIG1

9.84e-07235224337570
Pubmed

Spontaneous atopic dermatitis due to immune dysregulation in mice lacking Adamts2 and 14.

ADAMTS14 ADAMTS2

9.84e-07235229649548
Pubmed

Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2.

INSIG2 INSIG1

2.95e-06335231953408
Pubmed

Induction of human ADAMTS-2 gene expression by IL-1α is mediated by a multiple crosstalk of MEK/JNK and PI3K pathways in osteoblast like cells.

ADAMTS3 ADAMTS2

2.95e-06335226232334
Pubmed

Epithelial SCAP/INSIG/SREBP signaling regulates multiple biological processes during perinatal lung maturation.

INSIG2 INSIG1

2.95e-06335224806461
Pubmed

Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines.

INSIG2 INSIG1

2.95e-06335216549805
Pubmed

IL-6 upregulates a disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS-2) in human osteosarcoma cells mediated by JNK pathway.

ADAMTS3 ADAMTS2

2.95e-06335224752352
Pubmed

A genome-wide association study identifies a gene network of ADAMTS genes in the predisposition to pediatric stroke.

ADAMTS12 ADAMTS2

2.95e-06335222990015
Pubmed

Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2α-ATF4 axis.

INSIG2 INSIG1

2.95e-06335234298014
Pubmed

Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain.

ADAMTS14 ADAMTS2

2.95e-06335231152061
Pubmed

Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.

INSIG2 INSIG1

2.95e-06335212482938
Pubmed

Cholesterol metabolism plays a crucial role in the regulation of autophagy for cell differentiation of granular convoluted tubules in male mouse submandibular glands.

INSIG2 INSIG1

2.95e-06335231558435
Pubmed

Polymorphisms in MUC1, MUC2, MUC5B and MUC6 genes are not associated with the risk of chronic atrophic gastritis.

MUC5B MUC6

5.90e-06435221596555
Pubmed

Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.

INSIG2 INSIG1

5.90e-06435215899885
Pubmed

Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype.

MUC5B MUC6

5.90e-06435223807779
Pubmed

Interactions among genetic variants from SREBP2 activating-related pathway on risk of coronary heart disease in Chinese Han population.

INSIG2 INSIG1

5.90e-06435219740467
Pubmed

Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs.

INSIG2 INSIG1

5.90e-06435212842885
Pubmed

Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells.

MUC5B MUC6

5.90e-06435217471237
Pubmed

Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis.

INSIG2 INSIG1

5.90e-06435216606821
Pubmed

The mouse secreted gel-forming mucin gene cluster.

MUC5B MUC6

5.90e-06435214984930
Pubmed

ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats.

ADAMTS3 ADAMTS2

5.90e-06435210094461
Pubmed

Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse.

MUC5B MUC6

5.90e-06435212676567
Pubmed

Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells.

MUC5B MUC6

5.90e-06435229869461
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

ADAMTS15 ZNF592 BIRC6 SSPOP ZNF408 RYR1 ADGRB1

7.42e-0673635729676528
Pubmed

Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic Fissure.

ADAMTS12 ADAMTS15

9.82e-06535229625437
Pubmed

Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase.

INSIG2 INSIG1

9.82e-06535229374057
Pubmed

[ADAMTS family--new extracellular matrix degrading enzyme].

ADAMTS3 ADAMTS2

9.82e-06535211831030
Pubmed

Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.

INSIG2 INSIG1

9.82e-06535222143767
Pubmed

Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene.

INSIG2 INSIG1

9.82e-06535230733434
Pubmed

Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?

INSIG2 INSIG1

9.82e-06535218195716
Pubmed

Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: a genetic association study.

ADAMTS14 ADAMTS2

9.82e-06535223491141
Pubmed

Comprehensive glycomics comparison between colon cancer cell cultures and tumours: implications for biomarker studies.

MUC5B MUC6

9.82e-06535224840470
Pubmed

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.

INSIG2 INSIG1

9.82e-06535216100574
Pubmed

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.

INSIG2 INSIG1

9.82e-06535212242332
Pubmed

The gene-gene interaction of INSIG-SCAP-SREBP pathway on the risk of obesity in Chinese children.

INSIG2 INSIG1

9.82e-06535225028659
Pubmed

Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.

MUC5B MUC6

1.47e-05635219110483
Pubmed

Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.

ADAMTS15 ADAMTS14

2.06e-05735211867212
Pubmed

Scavenger receptor CD36 mediates inhibition of cholesterol synthesis via activation of the PPARγ/PGC-1α pathway and Insig1/2 expression in hepatocytes.

INSIG2 INSIG1

2.74e-05835224371122
Pubmed

A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum.

ADAMTS3 ADAMTS2

3.53e-05935231491533
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

THSD7A SSPOP MUC6

5.09e-057135333541421
Pubmed

Hydrocephalus in mouse B3glct mutants is likely caused by defects in multiple B3GLCT substrates in ependymal cells and subcommissural organ.

ADAMTS20 ADAMTS3

5.38e-051135233909046
Pubmed

Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102.

DLG3 ADGRB1

6.45e-051235211937501
Pubmed

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.

INSIG2 RSPO3 ZNF408

7.01e-057935322504420
Pubmed

ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family.

ADAMTS3 ADAMTS2

1.33e-041735210464288
Pubmed

Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis.

INSIG2 INSIG1

1.49e-041835229899135
Pubmed

Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.

MUC5B MUC6

1.49e-041835218834073
Pubmed

ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.

ADAMTS15 ADAMTS20

1.85e-042035219922873
Pubmed

Myocardial Angiopoietin-1 Controls Atrial Chamber Morphogenesis by Spatiotemporal Degradation of Cardiac Jelly.

ADAMTS3 ADAMTS2

2.68e-042435229791855
Pubmed

Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.

ADAMTS12 ADAMTS3

2.68e-042435232212159
Pubmed

Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun.

PTN RSPO3 THBS2

3.80e-0414035326930384
Pubmed

Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes.

INSIG2 INSIG1

4.79e-043235219815544
Pubmed

Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal Myofibroblasts in the Developing Mouse Kidney.

PTN THBS2

6.41e-043735235918150
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2

2.08e-131928650
GeneFamilyCD molecules|Mucins

MUC5B MUC6

4.77e-0421282648
CoexpressionNABA_MATRISOME

ADAMTS12 ADAMTS15 PTN RSPO3 ADAMTS20 DPT THBS2 MUC5B ADAMTS14 ADAMTS3 ADAMTS2 SSPOP MUC6 ADAMTSL2

1.54e-1110083514MM17056
CoexpressionNABA_MATRISOME

ADAMTS12 ADAMTS15 PTN RSPO3 ADAMTS20 DPT THBS2 MUC5B ADAMTS14 ADAMTS3 ADAMTS2 SSPOP MUC6 ADAMTSL2

1.96e-1110263514M5889
CoexpressionNABA_ECM_REGULATORS

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2 ADAMTSL2

2.52e-08238357M3468
CoexpressionNABA_ECM_REGULATORS

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14 ADAMTS3 ADAMTS2 ADAMTSL2

2.83e-08242357MM17062
CoexpressionNABA_MATRISOME_ASSOCIATED

ADAMTS12 ADAMTS15 PTN ADAMTS20 MUC5B ADAMTS14 ADAMTS3 ADAMTS2 MUC6 ADAMTSL2

2.86e-087383510MM17058
CoexpressionNABA_MATRISOME_ASSOCIATED

ADAMTS12 ADAMTS15 PTN ADAMTS20 MUC5B ADAMTS14 ADAMTS3 ADAMTS2 MUC6 ADAMTSL2

3.37e-087513510M5885
CoexpressionAIZARANI_LIVER_C21_STELLATE_CELLS_1

PTN DPT THBS2 ADAMTS2 ADAMTSL2

5.72e-06194355M39122
CoexpressionDESCARTES_FETAL_HEART_STROMAL_CELLS

PTN DPT ADAMTS2

1.27e-0534353M40199
CoexpressionCUI_DEVELOPING_HEART_C3_FIBROBLAST_LIKE_CELL

PTN DPT THBS2 ADAMTS2

1.77e-05117354M39300
CoexpressionDESCARTES_FETAL_ADRENAL_STROMAL_CELLS

ADAMTS15 RSPO3 THBS2 ADAMTS14

5.47e-05156354M40151
CoexpressionNABA_ECM_GLYCOPROTEINS

RSPO3 DPT THBS2 SSPOP

1.20e-04191354MM17059
CoexpressionNABA_ECM_GLYCOPROTEINS

RSPO3 DPT THBS2 SSPOP

1.32e-04196354M3008
CoexpressionGSE8921_UNSTIM_0H_VS_TLR1_2_STIM_MONOCYTE_24H_UP

ADAMTS15 DPT THBS2 EML6

1.40e-04199354M6410
CoexpressionLY_AGING_MIDDLE_UP

DPT THBS2

1.56e-0414352M19146
CoexpressionDESCARTES_FETAL_EYE_STROMAL_CELLS

DPT THBS2 ADAMTS2

2.44e-0491353M40180
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP

PTN RSPO3 DLG3 ADAMTSL2 ADGRB1

3.10e-04450355M1350
CoexpressionGAO_LARGE_INTESTINE_24W_C1_DCLK1POS_PROGENITOR

DPT THBS2 ADAMTS2

3.13e-0499353M39152
CoexpressionNABA_CORE_MATRISOME

RSPO3 DPT THBS2 SSPOP

4.48e-04270354MM17057
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP

PTN RSPO3 DLG3 ADAMTSL2 ADGRB1

4.57e-04490355MM1001
CoexpressionNABA_CORE_MATRISOME

RSPO3 DPT THBS2 SSPOP

4.80e-04275354M5884
CoexpressionHAY_BONE_MARROW_STROMAL

PTN INSIG2 RSPO3 DPT THBS2 ADAMTS2

4.84e-04767356M39209
CoexpressionSTEGER_ADIPOGENESIS_DN

DPT THBS2

5.10e-0425352M2271
CoexpressionSTEGER_ADIPOGENESIS_DN

DPT THBS2

5.10e-0425352MM898
CoexpressionAtlasFacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_2500_k-means-cluster#1

ADAMTS12 INSIG2 THBS2 ADAMTS2 MUC6 UNC5D EML6

4.70e-06420357Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_2500_K1
CoexpressionAtlasFacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#1

ADAMTS12 INSIG2 ADAMTS20 THBS2 ADAMTS2 MUC6 UNC5D

8.75e-06462357Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_2500_K1
CoexpressionAtlasDevelopingLowerUrinaryTract_P2_bladder stroma (LCM)_emap-30396_k-means-cluster#4_top-relative-expression-ranked_200

DPT THBS2 ADAMTS2

1.79e-0531353gudmap_developingLowerUrinaryTract_P2_bladder stroma (LCM)_200_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_emap-3087_k-means-cluster#1_top-relative-expression-ranked_1000

RSPO3 ADAMTS20 THSD7A ADAMTS3 UNC5D

3.48e-05229355gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_1000_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#3_top-relative-expression-ranked_1000

ADAMTS15 RSPO3 ADAMTS20 THSD7A ADAMTS3

4.62e-05243355gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000_k3
CoexpressionAtlasFacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_2500_k-means-cluster#3

ADAMTS12 INSIG2 THBS2 ADAMTS2 MUC6 UNC5D

5.69e-05419356Facebase_RNAseq_e9.5_Olfactory Placode_2500_K3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#2_top-relative-expression-ranked_200

RSPO3 ADAMTS3 UNC5D

9.61e-0554353gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_200_k2
CoexpressionAtlasFacebaseRNAseq_e9.5_Facial Mesenchyne_top-relative-expression-ranked_2500_k-means-cluster#1

ADAMTS12 INSIG2 THBS2 ADAMTS2 MUC6 UNC5D

1.64e-04508356Facebase_RNAseq_e9.5_Facial Mesenchyne_2500_K1
CoexpressionAtlasDevelopingLowerUrinaryTract_P2_bladder stroma (LCM)_emap-30396_k-means-cluster#4_top-relative-expression-ranked_100

DPT THBS2

2.04e-0413352gudmap_developingLowerUrinaryTract_P2_bladder stroma (LCM)_100_k4
CoexpressionAtlasFacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_2500_k-means-cluster#4

ADAMTS12 INSIG2 THBS2 ADAMTS2 MUC6 UNC5D

2.04e-04529356Facebase_RNAseq_e10.5_Olfactory Pit_2500_K4
CoexpressionAtlasFacebaseRNAseq_e9.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#5

ADAMTS12 INSIG2 THBS2 ADAMTS2 MUC6 UNC5D

2.06e-04530356Facebase_RNAseq_e9.5_Maxillary Arch_2500_K5
CoexpressionAtlasDevelopingGonad_P2_epididymis_emap-30199_k-means-cluster#1_top-relative-expression-ranked_500

DPT THBS2 ADAMTS2

2.17e-0471353gudmap_developingGonad_P2_epididymis_500_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_P2_bladder stroma (LCM)_emap-30396_k-means-cluster#5_top-relative-expression-ranked_500

DPT THBS2 ADAMTS2

2.76e-0477353gudmap_developingLowerUrinaryTract_P2_bladder stroma (LCM)_500_k5
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_1000

ADAMTS15 RSPO3 ADAMTS20 THSD7A ADAMTS3 BIRC6 TMX4

2.93e-04806357gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_P2_bladder stroma (LCM)_emap-30396_top-relative-expression-ranked_100

DPT THBS2 ADAMTS2

3.32e-0482353gudmap_developingLowerUrinaryTract_P2_bladder stroma (LCM)_100
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#2_top-relative-expression-ranked_1000

RSPO3 ADAMTS20 THSD7A ADAMTS3 UNC5D

3.60e-04377355gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000_k2
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_ureter_emap-30363_k-means-cluster#1_top-relative-expression-ranked_500

DPT THBS2 ADAMTS2

3.82e-0486353gudmap_developingLowerUrinaryTract_P1_ureter_500_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#5_top-relative-expression-ranked_500

RSPO3 ADAMTS20 ADAMTS3 UNC5D

4.33e-04217354gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_500_k5
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_k-means-cluster#5_top-relative-expression-ranked_200

RSPO3 ADAMTS3 UNC5D

4.51e-0491353gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_200_k5
CoexpressionAtlasFacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#3

ADAMTS12 INSIG2 ADAMTS2 MUC6 UNC5D

5.28e-04410355Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_2500_K3
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#5_top-relative-expression-ranked_1000

PTN RSPO3 THBS2 ADAMTS2

5.76e-04234354gudmap_developingGonad_e18.5_epididymis_1000_k5
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_top-relative-expression-ranked_500

RSPO3 ADAMTS20 THSD7A ADAMTS3 ADAMTS2

5.95e-04421355gudmap_developingKidney_e15.5_Peripheral blastema_500
CoexpressionAtlaskidney_adult_RenalCapsule_k-means-cluster#1_top-relative-expression-ranked_500

RSPO3 DPT ADAMTS3 ADAMTS2

6.33e-04240354gudmap_kidney_adult_RenalCapsule_k1_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_emap-3087_k-means-cluster#3_top-relative-expression-ranked_500

RSPO3 ADAMTS3 UNC5D

6.48e-04103353gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_500_k3
CoexpressionAtlasFacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_500_k-means-cluster#5

THBS2 ADAMTS2 EML6

6.48e-04103353Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_500_K5
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#1

ADAMTS12 INSIG2 ADAMTS2 MUC6 UNC5D

6.75e-04433355Facebase_RNAseq_e10.5_Mandibular Arch_2500_K1
CoexpressionAtlasStromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4

ADAMTS12 ADAMTS15 DPT THBS2 ADAMTS2

7.04e-04437355GSM777046_500
CoexpressionAtlasStromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4

ADAMTS12 PTN DPT THBS2 THSD7A

8.44e-04455355GSM777055_500
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_2500_k-means-cluster#4

INSIG2 THBS2 ADAMTS2 MUC6 UNC5D

8.61e-04457355Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_2500_K4
CoexpressionAtlasFacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_2500_k-means-cluster#1

ADAMTS12 INSIG2 ADAMTS2 MUC6 UNC5D

9.13e-04463355Facebase_RNAseq_e8.5_Paraxial Mesoderm_2500_K1
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#2_top-relative-expression-ranked_1000

ADAMTS12 PTN ADAMTS3 ADAMTS2

9.16e-04265354gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k2_1000
CoexpressionAtlasStromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5

ADAMTS12 DPT THBS2 THSD7A ADAMTS2

9.39e-04466355GSM777050_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#1_top-relative-expression-ranked_1000

ADAMTS20 THSD7A ADAMTS3

1.01e-03120353gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000_k1
CoexpressionAtlasFacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_2500_k-means-cluster#4

RSPO3 THSD7A ADAMTS3 INSIG1 ADAMTSL2 TMX4

1.05e-03721356Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_2500_K4
CoexpressionAtlasDevelopingLowerUrinaryTract_P2_bladder stroma (LCM)_emap-30396_k-means-cluster#2_top-relative-expression-ranked_100

THBS2 ADAMTS2

1.12e-0330352gudmap_developingLowerUrinaryTract_P2_bladder stroma (LCM)_100_k2
CoexpressionAtlasFacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_2500_k-means-cluster#3

RSPO3 THSD7A ADAMTS3 INSIG1 ADAMTSL2 TMX4

1.12e-03730356Facebase_RNAseq_e8.5_Paraxial Mesoderm_2500_K3
CoexpressionAtlasFacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#5

RSPO3 THSD7A ADAMTS3 INSIG1 ADAMTSL2 TMX4

1.23e-03743356Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_2500_K5
CoexpressionAtlasFacebaseRNAseq_e9.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#2

RSPO3 THSD7A ADAMTS3 INSIG1 ADAMTSL2 TMX4

1.26e-03747356Facebase_RNAseq_e9.5_Maxillary Arch_2500_K2
CoexpressionAtlasDevelopingLowerUrinaryTract_P2_bladder detrusor (LCM)_emap-30376_k-means-cluster#2_top-relative-expression-ranked_200

DPT THBS2

1.35e-0333352gudmap_developingLowerUrinaryTract_P2_bladder detrusor (LCM)_200_k2
CoexpressionAtlasDevelopingGonad_P2_epididymis_emap-30199_k-means-cluster#5_top-relative-expression-ranked_1000

DPT THBS2 ADAMTS2

1.61e-03141353gudmap_developingGonad_P2_epididymis_1000_k5
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_top-relative-expression-ranked_1000

PTN RSPO3 DPT THBS2 ADAMTS2 BIRC6

1.78e-03799356gudmap_developingGonad_e18.5_epididymis_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#4_top-relative-expression-ranked_1000

ADAMTS15 RSPO3 ADAMTS3

1.81e-03147353DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k4_1000
CoexpressionAtlasgallbladder

THBS2 MUC5B ADAMTS14

1.84e-03148353gallbladder
ToppCellE16.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_immature|E16.5-samps / Age Group, Lineage, Cell class and subclass

PTN RSPO3 ADAMTS20 ADAMTS2 ADGRB1

5.43e-081293555e4783cc63afdeaebdfaecb72f95f3efc8d3c4a3
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTN RSPO3 DPT THBS2 ADAMTS2

1.85e-071653554e13fccd32029e2879e85f8966e582a46c09e4aa
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTN RSPO3 DPT THBS2 ADAMTS2

1.97e-07167355fe3338f99f94c0dac37e3d649dfdce82e4a56022
ToppCellPND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_DCN|PND07-28-samps / Age Group, Lineage, Cell class and subclass

ADAMTS12 RSPO3 DPT THBS2 ADAMTS2

2.55e-0717635508f94b78b27feeb113dbfadbfa7fe34d08b2809b
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTS15 DPT ADAMTS3 ADAMTS2 ADAMTSL2

3.27e-071853559faa35ceb89ccd2979072286f063687c9f846ce3
ToppCelldroplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS15 RSPO3 THBS2 ADAMTS2 ADAMTSL2

3.27e-0718535540e958511790e84321da5ccf735f9974c06a0263
ToppCelldroplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS15 RSPO3 THBS2 ADAMTS2 ADAMTSL2

3.27e-071853555f2eeba80aff145e85cfd81e2890a155406badb9
ToppCelldroplet-Liver-LIVER_HEP-30m-Mesenchymal|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS15 RSPO3 THBS2 ADAMTS2 ADAMTSL2

3.27e-07185355f814ec9d4ade717a0109398e9768d0d66f09317b
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADAMTS12 DPT THBS2 THSD7A ADAMTS2

3.54e-07188355bba6b273bd47dd0e27fde914e9e6fc9d76fd5176
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 PTN THBS2 ADAMTS2 ADAMTSL2

3.83e-0719135539092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCellmetastatic_Lymph_Node-Fibroblasts-Myofibroblasts|metastatic_Lymph_Node / Location, Cell class and cell subclass

ADAMTS12 DPT THBS2 ADAMTS2 ADAMTSL2

3.83e-07191355aa43b472bc8362f79ae63f09f1ca764718bbf22c
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PTN RSPO3 DPT THBS2 ADAMTS2

3.83e-07191355053b3664f509baa107feaf90730f80ebf9ac8f14
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 PTN THBS2 ADAMTS2 ADAMTSL2

3.83e-07191355ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPT THBS2 THSD7A ADAMTS2 ADAMTSL2

3.93e-07192355671d4e1eee5aba03c43dbc98f4b51ce42b3df5d5
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 RSPO3 THBS2 ADAMTS2 ADAMTSL2

3.93e-071923555105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 RSPO3 THBS2 ADAMTS2 ADAMTSL2

3.93e-07192355d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPT THBS2 THSD7A ADAMTS2 ADAMTSL2

3.93e-07192355840a34c1b82d218be999ab5e1bcafd6370d7a4b1
ToppCellMesenchymal-matrix_fibroblast_2_cell|World / Lineage, Cell type, age group and donor

ADAMTS15 RSPO3 DPT THBS2 ADAMTS2

3.93e-07192355a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PTN DPT THBS2 ADAMTS2 ADAMTSL2

4.03e-07193355dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PTN DPT THBS2 ADAMTS2 ADAMTSL2

4.03e-07193355e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 PTN THBS2 ADAMTS2 ADAMTSL2

4.14e-07194355ba7f971fb9a19423602da60770f23d9fead4a451
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 PTN THBS2 ADAMTS2 ADAMTSL2

4.14e-07194355cf0244a29934e515446ac917d3c30672b460fb04
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 RSPO3 THBS2 ADAMTS2 ADAMTSL2

4.24e-07195355dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 RSPO3 THBS2 ADAMTS3 ADAMTSL2

4.24e-071953553c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 RSPO3 THBS2 ADAMTS2 ADAMTSL2

4.24e-0719535549c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts-Subpleural_fibroblasts_L.2.1.5.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS15 PTN RSPO3 DPT THBS2

4.35e-0719635546d665de09f8164690b9a3e0acf0b0afa3f81b3d
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PTN DPT THBS2 ADAMTS2 ADAMTSL2

4.46e-071973554cf4e9553397cd8dee883dbec24f41bec41aff99
ToppCell(5)_Fibroblasts-(5)_Fibroblast-B_(Myofibroblast)|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

ADAMTS12 PTN DPT THBS2 ADAMTS2

4.58e-07198355196257c4420ac801ed9fbb444f11718adb7560ae
ToppCellbackground-Hepatic_Stellate_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

ADAMTS15 RSPO3 THBS2 ADAMTS2 ADAMTSL2

4.58e-07198355bd11b0e9e80449aab979a02c1023e0638c431c7c
ToppCellbackground-Hepatic_Stellate_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

ADAMTS15 RSPO3 DPT THBS2 ADAMTS2

4.58e-0719835579f32f965aed6a10c5cb803173e3db7b32e07a91
ToppCell10x3'2.3-week_17-19-Mesenchymal_fibro-stroma-arteriolar_fibroblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ADAMTS12 ADAMTS15 PTN DPT THBS2

4.69e-0719935595d95e9b7bd3933188998ae94986213eb0f1e5ea
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PTN RSPO3 DPT THBS2 ADAMTS2

4.81e-07200355933b5b400e48a511ba0a056be1d33d3610b5f10d
ToppCell367C-Fibroblasts-Fibroblast-B_(Myofibroblast)|367C / Donor, Lineage, Cell class and subclass (all cells)

ADAMTS12 PTN DPT THBS2 ADAMTS2

4.81e-07200355731e55070a7ff315091855bd88cda30e5a7e1a98
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PTN RSPO3 DPT THBS2 ADAMTS2

4.81e-07200355cbf6a6c3db88bac37bd084a3a914b12b3af524eb
ToppCell367C-Fibroblasts-Fibroblast-B_(Myofibroblast)-|367C / Donor, Lineage, Cell class and subclass (all cells)

ADAMTS12 PTN DPT THBS2 ADAMTS2

4.81e-07200355082e718c1da3f4fdd33a001d15ad3ddb2be985c7
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

ADAMTS12 PTN DPT THBS2 ADAMTS2

4.81e-072003554f7e26b27bd51c32420ed8c2f52d070aee542159
ToppCell(5)_Fibroblast-B_(Myofibroblast)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

ADAMTS12 PTN DPT THBS2 ADAMTS2

4.81e-072003559bbaa666d0f3b4782c1b4b95e0fa5fc1467842d8
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-Myofibroblasts|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

ADAMTS12 PTN DPT THBS2 ADAMTS2

4.81e-07200355ca777a7d001848f6d01c613ff2bda7e4f3e20521
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PTN RSPO3 DPT THBS2 ADAMTS2

4.81e-0720035510f0c20ba7c71d9e2e177597f85b41cb40f0d878
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-4|TCGA-Lung / Sample_Type by Project: Shred V9

ADAMTS12 THBS2 ADAMTS14 ADAMTS2

8.97e-06168354aefea14b8b1c1b6a05f827effd22ba15274fddc9
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSPO3 DPT THBS2 ADAMTS2

9.18e-061693548bfa2d3bb541d02f55d7c95b8fd156c8403befca
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSPO3 DPT THBS2 ADAMTS2

9.18e-06169354bb43abad2c049b7f4d307737347290e01b3339a3
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSPO3 DPT THBS2 ADAMTS2

9.18e-061693545f18e3f40a5b1b167903f37516ec8181e889c7c5
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTN DPT THBS2 ADAMTS2

9.18e-06169354031465190cd3623a25ef2b868daab8d932c8ff08
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 THBS2 ADAMTS2 ADAMTSL2

9.18e-06169354a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTN DPT THBS2 ADAMTS2

9.62e-0617135415cb4670ff4234ac46aea8a5911138d6913c4482
ToppCell5'-Adult-LargeIntestine-Mesenchymal-stromal_related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTS12 PTN RSPO3 DPT

1.05e-05175354b8995e7ada85ba959f06264a0295b61e390c4e6c
ToppCell5'-Adult-LargeIntestine-Mesenchymal-stromal_related-T_reticular|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTS12 PTN RSPO3 DPT

1.05e-051753547ae76bd3b4f610b2f98716a4456437cd3696b686
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Neuronal-Granular_Neuron_CB_Gabra6|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS15 RSPO3 KCNC4 P2RX6

1.10e-051773549b02fd91c110b405eba6cb74ceb90b1286535973
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ADAMTS12 RSPO3 ADAMTS20 ADAMTS2

1.13e-051783549fc5688cf705a74398d24e10e0aab4758612e72b
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6|TCGA-Ovary / Sample_Type by Project: Shred V9

ADAMTS12 THBS2 ADAMTS14 ADAMTS2

1.13e-05178354142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCell356C-Fibroblasts-Fibroblast-E-|356C / Donor, Lineage, Cell class and subclass (all cells)

RSPO3 THBS2 ADAMTS3 ADAMTSL2

1.13e-05178354a493a277d175e5e153410a745b26ebe2e0839ea0
ToppCell356C-Fibroblasts-Fibroblast-E|356C / Donor, Lineage, Cell class and subclass (all cells)

RSPO3 THBS2 ADAMTS3 ADAMTSL2

1.13e-05178354371218babddfd3d8a7bb82a46ce65327ee3fcf12
ToppCellfacs-Pancreas-Endocrine-24m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTN RSPO3 THBS2 ADAMTS2

1.15e-051793546f51a4580c06fc55cc764052c9b26f7c55660282
ToppCellfacs-Pancreas-Endocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTN RSPO3 THBS2 ADAMTS2

1.15e-05179354a6ce1fa338d4905bd6afef00763ac83e916a0b37
ToppCellfacs-Pancreas-Endocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTN RSPO3 THBS2 ADAMTS2

1.15e-05179354f14440f6ce9b4fcdd4bcb2488b949f9a0e17bc23
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS12 DPT THBS2 ADAMTS14

1.18e-05180354935c091bbcd6d10b81dc4731779e5bd98205c99f
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAMTS15 DPT ADAMTS3 ADAMTS2

1.18e-0518035408ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell5'-Airway_Nasal-Mesenchymal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS12 DPT THBS2 ADAMTS14

1.18e-051803543dd384b7f3d9582b8fec9fe05100e466e6218b76
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAMTS15 DPT ADAMTS3 ADAMTS2

1.18e-051803549b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCellPericytes-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

ADAMTS12 PTN THBS2 ADAMTS14

1.20e-0518135435c470988a93381eefa300831aabb813fa1b90bd
ToppCellfacs-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PTN RSPO3 THBS2 THSD7A

1.20e-05181354cc77ac0e223e012767222e45c5dcadc246d1aa7c
ToppCellfacs-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PTN RSPO3 THBS2 THSD7A

1.20e-05181354b0fff0defba9aea6fba36e378b05a59986e2573a
ToppCellfacs-Lung-18m-Endothelial-lymphatic_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PTN RSPO3 THBS2 THSD7A

1.20e-05181354ecd52f33841f4e9d946a4edad0d58da9b0cc5ffa
ToppCellNS-moderate-d_16-33-Lymphoid-NK|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ADAMTS12 RSPO3 DPT THBS2

1.23e-05182354fb503f8ecd013f1f2161a5841572b57cfcddb6fa
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-1|TCGA-Thryoid / Sample_Type by Project: Shred V9

ADAMTS12 THBS2 ADAMTS14 ADAMTS2

1.26e-0518335406e4b05d86a7d643569e19575c2c9aa351d33f29
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS12 DPT THBS2 ADAMTS14

1.26e-051833546d98973098c6d20c5305bce6a83a549a7d8dbfba
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS12 DPT THBS2 ADAMTS14

1.26e-05183354cc7f5a17b40e8d901885174922e5fa8877643071
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS12 DPT THBS2 ADAMTS14

1.26e-05183354803376f5260de83c48d4f7301278d078a32b3e6e
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS20 MUC5B SSPOP UNC5D

1.28e-05184354ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellP07-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PTN DPT THBS2 ADAMTS2

1.28e-0518435401257e5c12e38b849fd3d9496c43ded666249ba5
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS20 MUC5B SSPOP UNC5D

1.28e-051843542cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS20 MUC5B SSPOP UNC5D

1.28e-051843542b19a8c5f823e00812908b23e66bb4e563278aff
ToppCelldroplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DPT THSD7A ADAMTS2 P2RX6

1.28e-05184354e33e2a887aafba7b6a31f00bb0dbe974b4359fd6
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS15 THSD7A UNC5D EML6

1.28e-05184354da06ff24ee2b2cf4715fdfce43030b2da9e0aaf8
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS12 DPT THBS2 ADAMTS2

1.31e-051853543cd0686a14e734a0f243070ab939adcb4c454478
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS12 DPT THBS2 ADAMTS2

1.31e-0518535400258f458cbf6d36449db95528a6b5038d731d2d
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS12 DPT THBS2 ADAMTS2

1.31e-05185354a94694e226856bc5b168464f52d76004145717a5
ToppCellmetastatic_Lymph_Node-Fibroblasts-COL14A1+_matrix_FBs|metastatic_Lymph_Node / Location, Cell class and cell subclass

RSPO3 DPT THBS2 ADAMTS2

1.31e-05185354506eee2c1b6e8acec3aa8b2c66868010006c4c14
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PTN DPT THBS2 ADAMTS2

1.31e-05185354c85bba1210f1d389add3e40be9b96abac40cf8c1
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PTN RSPO3 DPT THBS2

1.34e-051863547582b5154d8e5a4434817b5ab77a10b789ea2288
ToppCell5'-Adult-LargeIntestine-Mesenchymal-Pericytes-Pericyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTS12 PTN ADAMTS2 UNC5D

1.34e-051863540c477016c1b539b3086a8066c3c6443f08c222a3
ToppCellfacs-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTN RSPO3 DPT THBS2

1.37e-0518735490a1078b0303799fba5d2ca4fa12076fd75b78b1
ToppCellfacs-Pancreas-Exocrine-24m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTN RSPO3 DPT THBS2

1.37e-051873540f90bce2087aecfdbb377e6f46c6e468efbb6e28
ToppCellCOVID-19-kidney-Fibroblast-1|COVID-19 / Disease (COVID-19 only), tissue and cell type

ADAMTS12 THBS2 ADAMTS2 ADAMTSL2

1.37e-0518735476bfe8c42430a230a8bdf299575c444fb7780f24
ToppCellfacs-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTN RSPO3 DPT THBS2

1.37e-0518735476c957b2976d38adb45e07bcf96c689442e1fc20
ToppCelldroplet-Lung-nan-18m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTN RSPO3 THBS2 THSD7A

1.40e-0518835454550313db78b3b5b572fa1e67092c8f6f33aab5
ToppCelldroplet-Lung-nan-18m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTN RSPO3 THBS2 THSD7A

1.40e-05188354a6ed43fdd42d681c9fbb2fb368947ab7e41d8d7c
ToppCelldroplet-Pancreas-PANCREAS-30m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTN RSPO3 DPT ADAMTS2

1.43e-051893541821ae4a6e37ee4c6308071883f3f447a7c53c53
ToppCell10x5'v1-week_14-16-Mesenchymal_fibro-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PTN RSPO3 DPT THBS2

1.43e-05189354eccf3d49354a67c94f1ed7c15a98a48a5e8e2ed0
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS15 DPT THBS2 ADAMTS2

1.43e-05189354544d95df910f1b276995624509a7e41b219baca0
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADAMTS15 DPT ADAMTS2 ADAMTSL2

1.43e-0518935440cbd679dc0548bf5207e1b033c0597886ad6fe1
ToppCelldroplet-Pancreas-PANCREAS-30m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTN RSPO3 DPT ADAMTS2

1.43e-051893541e4d7e8dc98b3d70351e6a6c2aaf9ca01f141b8f
ToppCellfacs-Thymus-Epithelium-3m-Mesenchymal|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTN THBS2 THSD7A ADAMTS2

1.43e-051893541db5dd1ef2a65251af2d5696622d1dd9c4ae2b55
ToppCell10x5'v1-week_14-16-Mesenchymal_fibro|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PTN RSPO3 DPT THBS2

1.43e-0518935440764f461b8aa1d3a2c5a30590b7fb9307d47d09
ToppCellfacs-Thymus-Epithelium-3m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTN THBS2 THSD7A ADAMTS2

1.43e-05189354bfb1c183a8a2752a2368b74150e66181c6a9da48
ToppCellfacs-Thymus-Epithelium-3m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTN THBS2 THSD7A ADAMTS2

1.43e-0518935414833feea8f80744a06ece73f813eaeff8c4dd61
ToppCelldroplet-Pancreas-PANCREAS-30m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTN RSPO3 DPT ADAMTS2

1.43e-051893541dc415ed41815f4296dafd8cf7f3e014c44db1db
ToppCelldroplet-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PTN RSPO3 THBS2 THSD7A

1.46e-05190354e80d66ba0d5c263e94c1ab0b89d1dc7b837af3e1
ToppCelldroplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTN DPT THBS2 ADAMTS2

1.46e-051903548cb950effc449ae59a915132ecc079be54d1acfe
Drugtegafur

ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS14

8.37e-0749344CID000005386
Diseasebody fat distribution

THBS2 ADAMTS14 ADAMTS3 ADAMTS2

9.45e-05202354EFO_0004341
Diseaseanorectal malformation

THBS2 MUC5B

2.31e-0419352MONDO_0019938
Diseaseresponse to angiotensin receptor blocker

RSPO3 EML6

5.82e-0430352EFO_0010735
Diseaseglioblastoma (is_marker_for)

PTN ADGRB1

1.25e-0344352DOID:3068 (is_marker_for)
Diseasecorneal resistance factor

ADAMTS15 RSPO3 ADAMTS20 ADAMTS2

1.94e-03451354EFO_0010067
Diseasecholangiocarcinoma (is_marker_for)

MUC5B MUC6

2.63e-0364352DOID:4947 (is_marker_for)
DiseaseManic Disorder

THSD7A ZNF592

3.23e-0371352C0024713
DiseaseManic

THSD7A ZNF592

3.88e-0378352C0338831
DiseaseDepression, Bipolar

THSD7A ZNF592

3.98e-0379352C0005587
Diseaseresponse to anticonvulsant

ADAMTS20 THSD7A

4.59e-0385352GO_0036277
Diseasecarpal tunnel syndrome

ADAMTS14 ADAMTSL2

5.02e-0389352EFO_0004143
Diseasehypertrophic cardiomyopathy

ZNF592 MUC6

5.35e-0392352EFO_0000538
Diseasecentral corneal thickness

ADAMTS15 ADAMTS20 ADAMTS2

5.81e-03309353EFO_0005213

Protein segments in the cluster

PeptideGeneStartEntry
CSVCLVCWEPTDEPW

BIRC6

331

Q9NR09
SPWSVCSSTCGEGWQ

ADGRB1

361

O14514
PQSLGEPTECWWEEI

DPT

81

Q07507
PEPCEAWQVEPWSQC

ADAMTS12

1421

P58397
CSQPVWVTEEWGACS

ADAMTS14

906

Q8WXS8
GEPCPTWELSAWSPC

ADAMTS15

891

Q8TE58
TCASWQVGPWGPCTT

ADAMTS20

1076

P59510
QECSQPVWVTGEWEP

ADAMTS2

911

O95450
PVWVTGEWEPCSQTC

ADAMTS2

916

O95450
WSQPCDVWSIGCILI

CLK1

356

P49759
VVTTGCEPQCAWSEW

MUC5B

3566

Q9HC84
DCGEWQWSVCVPTSG

PTN

46

P21246
WGWRSSVDNCTIPCT

MUC6

651

Q6W4X9
CQVPGICWVVCSWLQ

NLRP10

351

Q86W26
EEPSCPSNWTWVEGS

ICAM5

576

Q9UMF0
AWWVPPCCGTAAAVV

INSIG1

126

O15503
VSSWTECPPTWCSPL

LY6L

36

H3BQJ8
PCDRQWTVSDWGPCS

ADAMTSL2

736

Q86TH1
WWVPPCCGTASAVIG

INSIG2

71

Q9Y5U4
QITWFVSWTPCPDCV

APOBEC3F

86

Q8IUX4
CPAQWKTGPWSECSV

ADAMTS3

966

O15072
SGPSWWPECTCTNRD

DLG3

101

Q92796
EWDTWTCVLGPTCEG

EML6

1171

Q6ZMW3
GQEPSCVWAGWVTPD

RYR1

1441

P21817
GTHRTCEIWSWCPVE

P2RX6

166

O15547
CEIWSWCPVESGVVP

P2RX6

171

O15547
TWSPWSVCSEPCRGT

SSPOP

1756

A2VEC9
TECEVSPWSAWGPCT

THSD7A

511

Q9UPZ6
PCPEDCVISEWGPWT

THSD7A

1161

Q9UPZ6
CVISEWGPWTQCVLP

THSD7A

1166

Q9UPZ6
VECPVNCQLSDWSPW

THSD7A

1281

Q9UPZ6
APWCPSCQQTDSEWE

TMX4

61

Q9H1E5
TGWTCQECQEWVPDR

ZNF592

981

Q92610
PWGDVCACEQSSGWT

ZNF408

116

Q9H9D4
VHCEVSEWNPWSPCT

RSPO3

146

Q9BXY4
SWCQSPCPHAWVVVA

SCART1

111

Q4G0T1
CTSLCPVDGSWEVWS

UNC5D

301

Q6UXZ4
PWAEWTQCSVTCGSG

THBS2

386

P35442
WSVEQACPQRTCPEW

ZNF606

121

Q8WXB4
TFWGIDETDVEPCCW

KCNC4

131

Q03721