Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ARHGEF5_35	ARHGEF5 ARHGEF35	4.73e-05	2	129	2	PF15441
Domain	ARHGEF5/35_N	ARHGEF5 ARHGEF35	4.73e-05	2	129	2	IPR029212
Domain	NPIP	NPIPB3 NPIPB5 NPIPB13	1.11e-04	14	129	3	IPR009443
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ENGASE CTC1 POLG NICN1 DGKQ PPP6R1 GRIN2D AHDC1 PLEKHM1 RYR1 PHC2 TYK2 KMT2D ADAMTS7 PLEKHO2 PLA2G4B PKD1 FGFR1 MBD5 ELL RIC1	3.32e-09	1105	139	21	35748872
Pubmed	Assembly and specific recognition of k29- and k33-linked polyubiquitin.	NEDD4L OTUD7B UBE2L3	5.16e-06	9	139	3	25752577
Pubmed	Fasting decreases plasma FGF21 in obese subjects and the expression of FGF21 receptors in adipose tissue in both lean and obese subjects.	FGF21 FGFR1	1.59e-05	2	139	2	30307155
Pubmed	The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue.	FGF21 FGFR1	1.59e-05	2	139	2	24024127
Pubmed	FGF21-FGFR1 Coordinates Phospholipid Homeostasis, Lipid Droplet Function, and ER Stress in Obesity.	FGF21 FGFR1	1.59e-05	2	139	2	27690692
Pubmed	FGF21-FGFR1 controls mitochondrial homeostasis in cardiomyocytes by modulating the degradation of OPA1.	FGF21 FGFR1	1.59e-05	2	139	2	37156793
Pubmed	Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue.	MAP3K14 TLX1	1.59e-05	2	139	2	10835686
Pubmed	The common P450 oxidoreductase variant A503V is not a modifier gene for 21-hydroxylase deficiency.	CYP21A2 POR	1.59e-05	2	139	2	18397975
Pubmed	Proximal FAD histidine residue influences interflavin electron transfer in cytochrome P450 reductase and methionine synthase reductase.	POR MTRR	1.59e-05	2	139	2	24589657
Pubmed	OTUD7B and NIK expression in non-small cell lung cancer: Association with clinicopathological features and prognostic implications.	MAP3K14 OTUD7B	1.59e-05	2	139	2	27499151
Pubmed	High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice.	POLG FGF21	1.59e-05	2	139	2	26124126
Pubmed	Hepatic energy state is regulated by glucagon receptor signaling in mice.	GCGR PCK1	1.59e-05	2	139	2	19662685
Pubmed	On the key role of secondary lymphoid organs in antiviral immune responses studied in alymphoplastic (aly/aly) and spleenless (Hox11(-)/-) mutant mice.	MAP3K14 TLX1	1.59e-05	2	139	2	9182687
Pubmed	Structure of human Roquin-2 and its complex with constitutive-decay element RNA.	RC3H2 RC3H1	1.59e-05	2	139	2	26249698
Pubmed	New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.	RC3H2 RC3H1 UBE2L3	4.08e-05	17	139	3	26489670
Pubmed	Image-based genome-wide siRNA screen identifies selective autophagy factors.	MTSS1 FAM13B STAT2 ADAMTS7 NUP93 MBD5	4.52e-05	159	139	6	22020285
Pubmed	Mutually exclusive mutation profiles define functionally related genes in muscle invasive bladder cancer.	RB1 KMT2D	4.75e-05	3	139	2	35073341
Pubmed	Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain.	NEDD4L UBE2L3	4.75e-05	3	139	2	18498246
Pubmed	Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity.	NEDD4L KCNJ10	4.75e-05	3	139	2	38032389
Pubmed	OTUD7B suppresses Smac mimetic-induced lung cancer cell invasion and migration via deubiquitinating TRAF3.	MAP3K14 OTUD7B	4.75e-05	3	139	2	33198776
Pubmed	KMT2D deficiency disturbs the proliferation and cell cycle activity of dental epithelial cell line (LS8) partially via Wnt signaling.	RB1 KMT2D	4.75e-05	3	139	2	34724040
Pubmed	Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation.	RB1 PKD1	4.75e-05	3	139	2	21900881
Pubmed	Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation.	RC3H2 RC3H1	4.75e-05	3	139	2	23583642
Pubmed	Elevated intracellular Na+ and osmolarity stimulate catalytic activity of the ubiquitin ligase Nedd4-2.	NEDD4L UBE2L3	4.75e-05	3	139	2	35858421
Pubmed	Roquin Paralogs Differentially Regulate Functional NKT Cell Subsets.	RC3H2 RC3H1	4.75e-05	3	139	2	28188245
Pubmed	circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer.	STAT2 CAPRIN1	4.75e-05	3	139	2	36328987
Pubmed	Whole-exome mutational landscape of neuroendocrine carcinomas of the gallbladder.	RB1 ALK	4.75e-05	3	139	2	33563892
Pubmed	Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents.	GCGR FGF21	4.75e-05	3	139	2	30150304
Pubmed	An Essential Role of Nedd4-2 in the Ubiquitination, Expression, and Function of Organic Anion Transporter-3.	NEDD4L SLC22A8	4.75e-05	3	139	2	26651153
Pubmed	Genome-wide analysis of copy-number variation in humans with cleft lip and/or cleft palate identifies COBLL1, RIC1, and ARHGEF38 as clefting genes.	COBLL1 RIC1	4.75e-05	3	139	2	36493769
Pubmed	Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation.	RC3H2 RC3H1	4.75e-05	3	139	2	25026077
Pubmed	FGF21 prevents neuronal cell ferroptosis after spinal cord injury by activating the FGFR1/β-Klotho pathway.	FGF21 FGFR1	4.75e-05	3	139	2	37660729
Pubmed	Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia.	STAT2 TYK2	4.75e-05	3	139	2	35708626
Pubmed	Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation.	RC3H2 RC3H1	4.75e-05	3	139	2	30232334
Pubmed	The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice.	NPAS3 FGFR1	4.75e-05	3	139	2	16172381
Pubmed	Aberrant anaplastic lymphoma kinase activity induces a p53 and Rb-dependent senescence-like arrest in the absence of detectable p53 stabilization.	RB1 ALK	4.75e-05	3	139	2	21423761
Pubmed	The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals.	STAT2 TYK2	4.75e-05	3	139	2	8605877
Pubmed	Divergent origins and concerted expansion of two segmental duplications on chromosome 16.	NPIPB3 NPIPB5	4.75e-05	3	139	2	11948212
Pubmed	FGFR1 Is Critical for RBL2 Loss-Driven Tumor Development and Requires PLCG1 Activation for Continued Growth of Small Cell Lung Cancer.	RB1 FGFR1	4.75e-05	3	139	2	32973083
Pubmed	Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21.	GCGR FGF21	4.75e-05	3	139	2	29925501
Pubmed	Understanding the physical interactions in the FGF21/FGFR/β-Klotho complex: structural requirements and implications in FGF21 signaling.	FGF21 FGFR1	4.75e-05	3	139	2	22248288
Pubmed	Cripto is required for mesoderm and endoderm cell allocation during mouse gastrulation.	SUPT20H MIXL1 FGFR1	7.88e-05	21	139	3	23747598
Pubmed	Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis.	STAT2 TYK2	9.47e-05	4	139	2	23653476
Pubmed	SGK1/Nedd4-2 signaling pathway regulates the activity of human organic anion transporters 3.	NEDD4L SLC22A8	9.47e-05	4	139	2	28608480
Pubmed	TRIM10 binds to IFN-α/β receptor 1 to negatively regulate type I IFN signal transduction.	STAT2 TYK2	9.47e-05	4	139	2	33811647
Pubmed	Fibroblast growth factor 21 mediates specific glucagon actions.	GCGR FGF21	9.47e-05	4	139	2	23305646
Pubmed	Kir5.1 regulates Nedd4-2-mediated ubiquitination of Kir4.1 in distal nephron.	NEDD4L KCNJ10	9.47e-05	4	139	2	29897283
Pubmed	Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.	RC3H2 RC3H1	9.47e-05	4	139	2	25697406
Pubmed	BetaKlotho is required for metabolic activity of fibroblast growth factor 21.	FGF21 FGFR1	9.47e-05	4	139	2	17452648
Pubmed	Renal Tubule Nedd4-2 Deficiency Stimulates Kir4.1/Kir5.1 and Thiazide-Sensitive NaCl Cotransporter in Distal Convoluted Tubule.	NEDD4L KCNJ10	9.47e-05	4	139	2	32295826
Pubmed	Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression.	GCGR FGF21	9.47e-05	4	139	2	31673703
Pubmed	Fibroblast growth factor 21 ameliorates cholestatic liver injury via a hepatic FGFR4-JNK pathway.	FGF21 FGFR1	9.47e-05	4	139	2	37696161
Pubmed	Impaired type I IFN-induced Jak/STAT signaling in FA-C cells and abnormal CD4+ Th cell subsets in Fancc-/- mice.	STAT2 TYK2	9.47e-05	4	139	2	15356134
Pubmed	The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway.	RB1 ALK	9.47e-05	4	139	2	21518927
Pubmed	Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity.	UBE2L3 FGFR1	9.47e-05	4	139	2	25292214
Pubmed	STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease.	PTPN5 UBE2L3	9.47e-05	4	139	2	25583483
Pubmed	SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2.	STAT2 TYK2	9.47e-05	4	139	2	32953130
Pubmed	Identification of a crucial amino acid responsible for the loss of specifying FGFR1-KLB affinity of the iodinated FGF21.	FGF21 FGFR1	9.47e-05	4	139	2	30317562
Pubmed	Dynamics and Distribution of Klothoβ (KLB) and fibroblast growth factor receptor-1 (FGFR1) in living cells reveal the fibroblast growth factor-21 (FGF21)-induced receptor complex.	FGF21 FGFR1	9.47e-05	4	139	2	22523080
Pubmed	A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation.	RC3H2 RC3H1	9.47e-05	4	139	2	31636267
Pubmed	The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice.	GCGR FGF21	9.47e-05	4	139	2	30772257
Pubmed	Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.	SUPT20H HEXIM1 PARP10 WDR97 VPS41 MTRR NBR1 ELL RIC1	9.81e-05	457	139	9	32968282
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	MAP3K14 STAT2 TYK2 TRIM56 VPS41 MAP3K9 FGFR1 ALK	1.33e-04	372	139	8	22939624
Pubmed	Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases.	IL12RB2 TYK2	1.57e-04	5	139	2	9038232
Pubmed	FGF21 signalling pathway and metabolic traits - genetic association analysis.	FGF21 FGFR1	1.57e-04	5	139	2	20717167
Pubmed	Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization.	GCGR PCK1	1.57e-04	5	139	2	37848446
Pubmed	Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.	STAT2 TYK2	1.57e-04	5	139	2	8605876
Pubmed	Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.	RC3H2 RC3H1	1.57e-04	5	139	2	27010430
Pubmed	Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis.	RYR1 PKD1	1.57e-04	5	139	2	11818962
Pubmed	Animal models of spontaneous pancreatic neuroendocrine tumors.	RB1 GCGR	1.57e-04	5	139	2	26261055
Pubmed	Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB.	FGF21 FGFR1	1.57e-04	5	139	2	22442730
Pubmed	Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.	GCGR FGF21	2.35e-04	6	139	2	27720451
Pubmed	Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase.	NEDD4L UBE2L3	2.35e-04	6	139	2	28461335
Pubmed	Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts.	MTSS1 PKD1	2.35e-04	6	139	2	20181743
Pubmed	Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength.	MNX1 KCNJ10	2.35e-04	6	139	2	29606582
Pubmed	A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.	IL12RB2 TYK2	2.35e-04	6	139	2	8943050
Pubmed	β-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation.	NEDD4L UBE2L3	2.35e-04	6	139	2	29964046
Pubmed	Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis.	FGF21 FGFR1	2.35e-04	6	139	2	28131861
Pubmed	IL-12 signaling drives CD8+ T cell IFN-gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii Infection.	IL12RB2 TYK2	2.35e-04	6	139	2	18424713
Pubmed	Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation.	RC3H2 RC3H1	2.35e-04	6	139	2	34471108
Pubmed	Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5.	NEDD4L UBE2L3	2.35e-04	6	139	2	8576257
Pubmed	Phospho-tyrosine dependent protein-protein interaction network.	DCAF8 RB1 AHDC1 STAT2 PHC2 OTUD7B FGF21 TNS4	2.56e-04	410	139	8	25814554
Pubmed	A census of human transcription factors: function, expression and evolution.	RC3H2 MNX1 TSHZ2 NPAS3 ESX1 VSX1 STAT2 ZFPM2 TLX1 KMT2D ZFHX4 MIXL1	3.01e-04	908	139	12	19274049
Pubmed	TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.	NEDD4L UBE2L3 TRIM56	3.12e-04	33	139	3	33567268
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TTLL3 DCAF8 NEDD4L TSHZ2 POLG ATAT1 SHROOM2 AHDC1 PLEKHM1 TYK2 PARP10 LRRC27 VPS41 MBD5 NBR1 RIC1	3.13e-04	1489	139	16	28611215
Pubmed	SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.	IL12RB2 NPAS3 NRG2 NPIPB3 SHROOM2 AHDC1 SNX19 ZFAND4 GFRA1 RYR1 PTPN5 LRRC27	3.22e-04	915	139	12	32393512
Pubmed	A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases.	NEDD4L UBE2L3	3.29e-04	7	139	2	30587574
Pubmed	STAT3 promotes motor neuron differentiation by collaborating with motor neuron-specific LIM complex.	MNX1 STAT2	3.29e-04	7	139	2	23798382
Pubmed	Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.	RC3H2 RC3H1	3.29e-04	7	139	2	34811541
Pubmed	Integrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients.	RB1 KMT2D	3.29e-04	7	139	2	24323028
Pubmed	Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.	NEDD4L UBE2L3	3.29e-04	7	139	2	20051513
Pubmed	HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK.	NEDD4L UBE2L3	3.29e-04	7	139	2	20086093
Pubmed	The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities.	NEDD4L UBE2L3	3.29e-04	7	139	2	16337426
Pubmed	The E3 Ubiquitin Ligase NEDD4L Targets OGG1 for Ubiquitylation and Modulates the Cellular DNA Damage Response.	NEDD4L UBE2L3	3.29e-04	7	139	2	33282879
Pubmed	TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg.	IL12RB2 TLR9	4.37e-04	8	139	2	32268093
Pubmed	Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.	DGKQ PLEKHM1	4.37e-04	8	139	2	20070850
Pubmed	Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.	NEDD4L UBE2L3	4.37e-04	8	139	2	17719543
Pubmed	betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c.	FGF21 FGFR1	4.37e-04	8	139	2	18187602
Pubmed	Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.	RC3H2 RC3H1	4.37e-04	8	139	2	29246441
Pubmed	Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.	FGF21 FGFR1	4.37e-04	8	139	2	17623664
Cytoband	16p12.2	NPIPB4 NPIPB3 NPIPB5	1.96e-04	37	139	3	16p12.2
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CATIP TTLL3 MAP3K14 NRG2 KCNJ10 ALPK3 ADGRA1	1.85e-06	184	139	7	6b0c110d8930df99043c3b99cf4d873985126960
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CATIP TTLL3 MAP3K14 NRG2 KCNJ10 ALPK3 ADGRA1	1.85e-06	184	139	7	35928fc5f7bbf8c7b09181a2bd27e22dff42ec16
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TSHZ2 HTRA3 ZFPM2 ZFHX4 FGFR1 CGNL1 MN1	3.00e-06	198	139	7	9541d68a1a6247dbd7161a62644eea6527c2c8ff
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NICN1 PLK5 MTSS1 GCGR ZFPM2 ZFHX4 INMT	3.10e-06	199	139	7	3835452e4848d7f7dd8651c17b746b271ef39688
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NICN1 PLK5 MTSS1 GCGR ZFPM2 PTPN5 INMT	3.10e-06	199	139	7	9c2db0bb94cba71a3cc1827844da090e213e0258
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MTSS1 NPAS3 GRIN2D ARSF ZFHX4 MN1 ALK	3.21e-06	200	139	7	d0167f96314be78b6d867bbcc6e4396071d931b8
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Hematologic-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RUBCNL ARHGAP30 PRSS36 GFRA1 ZFHX4 LRRC27	1.53e-05	169	139	6	15a9183c838cc6384d7f5dfeae3d30602964c9b3
ToppCell	Globus_pallidus-Neuronal-Inhibitory\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	DGKQ GRIN2D KCNC4 MAP3K9 ADGRA1 ALK	2.32e-05	182	139	6	04ccfa951eaa31fed6d140edb6c702d49363c5fa
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D122\|Adult / Lineage, Cell type, age group and donor	TSHZ2 HTRA3 GFRA1 ZFPM2 FGFR1 MN1	2.47e-05	184	139	6	2b7e6f91e11c228f0521e099886867d9e998e78d
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D175\|Adult / Lineage, Cell type, age group and donor	IL12RB2 RUBCNL MTSS1 NPAS3 RYR1 ELL	2.54e-05	185	139	6	ab5704b96f1d368911308797d10c7c52766ab134
ToppCell	5'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARHGEF5 MTSS1 PRSS22 NRG2 HEXIM1 CGNL1	3.04e-05	191	139	6	54f07e4de61735051498846afb44b1798bed8144
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TSHZ2 HTRA3 GFRA1 ZFPM2 FGFR1 MN1	3.13e-05	192	139	6	8d56e360ebc624ca4cd7f0af4f3cc599c244f134
ToppCell	Mesenchymal-matrix_fibroblast_2_cell\|World / Lineage, Cell type, age group and donor	TSHZ2 HTRA3 GFRA1 ZFPM2 FGFR1 MN1	3.13e-05	192	139	6	a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TSHZ2 HTRA3 GFRA1 ARSF ZFHX4 INMT	3.22e-05	193	139	6	7cd9671e0ac64f7f3607f564485c63abbb7e7a63
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	GLOD5 NPIPB4 TSHZ2 CTC1 NPIPB5 ALK	3.22e-05	193	139	6	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TSHZ2 HTRA3 GFRA1 ZFPM2 FGFR1 MN1	3.22e-05	193	139	6	9ab47b360bee1d4f1092c2269e58acebe9584021
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TSHZ2 HTRA3 GFRA1 ZFPM2 FGFR1 MN1	3.22e-05	193	139	6	261cafc167c86ab277be4ea7f08b0173e2dde26e
ToppCell	IPF-Epithelial-Mesothelial\|Epithelial / Disease state, Lineage and Cell class	ZFPM2 ZFHX4 INMT FGFR1 MN1 PCK1	3.32e-05	194	139	6	d8a26da856a85e3d001d406e992cb18fdd58baef
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TSHZ2 HTRA3 GFRA1 ZFPM2 FGFR1 MN1	3.32e-05	194	139	6	439d3f17c1f4736122b330e98add9292c7036a8e
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TSHZ2 CYP21A2 GFRA1 ZFPM2 FGFR1 MN1	3.42e-05	195	139	6	ff0aa455e9844a6d7ae57ff59fb6cea825cf1fc2
ToppCell	COPD-Stromal-Fibroblast\|World / Disease state, Lineage and Cell class	TSHZ2 HTRA3 GFRA1 ZFPM2 INMT FGFR1	3.72e-05	198	139	6	2f13c0b3372af53d1bd85f9546f315c878580a71
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-Neurons\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	ATAT1 PTPN5 ZFHX4 ADAMTS7 NUP93 MN1	3.72e-05	198	139	6	90ebefc9ba8dc2a81471e5693384f5ce56f06298
ToppCell	COPD-Stromal-Fibroblast\|COPD / Disease state, Lineage and Cell class	TSHZ2 HTRA3 GFRA1 ZFPM2 INMT FGFR1	3.72e-05	198	139	6	7904af61473cb20064f7a3a1e1bfe8d5913cf317
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MTSS1 VSX1 GFRA1 ADGRA1 FGFR1 PLXNB3	3.83e-05	199	139	6	333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MTSS1 VSX1 GFRA1 ADGRA1 FGFR1 PLXNB3	3.83e-05	199	139	6	e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell	wk_20-22-Mesenchymal-Fibroblast-Adventitial_fibro\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	TSHZ2 HTRA3 GFRA1 FGFR1 CGNL1 MN1	3.83e-05	199	139	6	ab0589c068c24aa989bdca083504fbad0c15221d
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TSHZ2 HTRA3 GFRA1 ZFPM2 FGFR1 MN1	3.93e-05	200	139	6	ad3fdcef895400f929f2ae12ff9bd85fd46adb3a
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MTSS1 VSX1 GFRA1 ADGRA1 FGFR1 PLXNB3	3.93e-05	200	139	6	ad777683adeb2ce45ade570386235e311fa7ea2d
ToppCell	Kidney-Fibroblasts\|Kidney / Skin and Kidney Cells in Lupus Nephritis Patients.	TSHZ2 HTRA3 ATAT1 ZFPM2 ZFHX4 PCYT1B	3.93e-05	200	139	6	2c265ad8314a21bce50ac21b16da2fea125366ea
ToppCell	primary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-OPC_Pdgfra_Grm5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	COBLL1 HTRA3 ADAMTS7 KCNJ10 PLXNB3	7.55e-05	139	139	5	a957ea4e581646c76b16b6a7f89579b8c7ac35b6
Disease	congenital adrenal hyperplasia (is_implicated_in)	CYP21A2 POR	2.86e-04	6	130	2	DOID:0050811 (is_implicated_in)
Disease	meningioma (is_implicated_in)	MTRR MN1	2.86e-04	6	130	2	DOID:3565 (is_implicated_in)
Disease	systemic scleroderma, rheumatoid arthritis, myositis, systemic lupus erythematosus	IL12RB2 DGKQ TYK2	6.30e-04	38	130	3	EFO_0000685, EFO_0000717, EFO_0000783, MONDO_0007915
Disease	Congenital adrenal hyperplasia	CYP21A2 POR	6.80e-04	9	130	2	C0001627
Disease	sciatic neuropathy (biomarker_via_orthology)	GFRA1 KCNC4 CACNA1I FGFR1	9.80e-04	99	130	4	DOID:11446 (biomarker_via_orthology)
Disease	fibroblast growth factor 21 measurement	PHC2 FGF21	1.03e-03	11	130	2	EFO_0010783
Disease	pulse pressure measurement	RC3H2 SFRP5 COBLL1 AHDC1 SNX19 ZFPM2 PHC2 ZFHX4 UBE2L3 GUCA2B PLEKHO2 PKD1 MBD5 ELL PHF13	1.23e-03	1392	130	15	EFO_0005763
Disease	intracranial aneurysm (is_implicated_in)	KMT2D PKD1	1.24e-03	12	130	2	DOID:10941 (is_implicated_in)
Disease	Male sterility	POLG KMT2D MTRR	1.25e-03	48	130	3	C0917731
Disease	Male infertility	POLG KMT2D MTRR	1.25e-03	48	130	3	C0021364
Disease	Subfertility, Male	POLG KMT2D MTRR	1.25e-03	48	130	3	C0848676
Disease	free androgen index	CYP21A2 NICN1 COBLL1 POR ZFPM2 TYK2 ZFHX4	1.38e-03	374	130	7	EFO_0007005
Disease	myeloid leukemia (is_implicated_in)	FGFR1 MN1	1.46e-03	13	130	2	DOID:8692 (is_implicated_in)
Disease	monocyte count	MAP3K14 SIGLEC5 ARHGAP30 AHDC1 PLEKHM1 RYR1 ZFPM2 WDR91 UBE2L3 PKD1 SEMA4A MBD5 MN1 ELL	2.09e-03	1320	130	14	EFO_0005091
Disease	cystatin-F measurement	VSX1 ZFPM2	2.22e-03	16	130	2	EFO_0008104
Disease	gliosarcoma	POR FGFR1	2.22e-03	16	130	2	C0206726
Disease	psoriasis vulgaris	STAT2 TYK2 UBE2L3	2.50e-03	61	130	3	EFO_1001494
Disease	fatty liver disease (is_marker_for)	FGF21 FGFR1	2.51e-03	17	130	2	DOID:9452 (is_marker_for)
Disease	choline measurement	CYP21A2 ZFPM2 UBE2L3 NUP93	2.66e-03	130	130	4	EFO_0010116
Disease	venous thromboembolism, fibrinogen measurement	CYP21A2 ZFPM2 PARP10	3.26e-03	67	130	3	EFO_0004286, EFO_0004623
Disease	joint damage measurement	COBLL1 MAP3K14 GFRA1	3.40e-03	68	130	3	EFO_0005413
Disease	Craniosynostosis	FGFR1 MN1	3.47e-03	20	130	2	C0010278
Disease	Bladder Neoplasm	RB1 POR KMT2D ANXA2R	3.48e-03	140	130	4	C0005695
Disease	Malignant neoplasm of urinary bladder	RB1 POR KMT2D ANXA2R	3.56e-03	141	130	4	C0005684
Disease	venous thromboembolism, plasminogen activator inhibitor 1 measurement	ZFPM2 TRIM56	3.83e-03	21	130	2	EFO_0004286, EFO_0004792
Disease	bipolar disorder	NPAS3 SNX19 PRSS36 OTUD7B CDAN1 PARP10 KMT2D FGFR1	4.13e-03	577	130	8	MONDO_0004985

Protein segments in the cluster

Peptide	Gene	Start	Entry
HNPPLLFDLSRDPSE	ARSF	501	P54793
APALDPALCVHLVPQ	ESX1	226	Q8N693
GLPLLTDCAQPSRPH	ELL	426	P55199
DPAVGLLRSCPHSLP	CCDC187	856	A0A096LP49
LLRSCPHSLPAAPTL	CCDC187	861	A0A096LP49
PCLLLAKHSQPLSDP	CTC1	631	Q2NKJ3
DALILPVPRPCLHSA	CTC1	696	Q2NKJ3
EIPDIHPLLACIDPL	C2orf78	391	A6NCI8
PAALSPSLEPIRCSH	ARHGEF5	446	Q12774
CPPRKDAHPALDANG	ADGRA1	321	Q86SQ6
LHDQDTRCAFLPRPP	ALPK3	86	Q96L96
PAALSPLLEPIRCSH	ARHGEF35	446	A5YM69
DPGHLELCRLPPSSQ	DGKQ	341	P52824
LPSEPCADHPLAARP	C1orf232	81	A0A0U1RR37
CADHPLAARPPSQAA	C1orf232	86	A0A0U1RR37
HCPLAEPLRLDLCSP	AHDC1	356	Q5TGY3
EAACLSAPHLASPPA	AHDC1	1496	Q5TGY3
DPHRAPALPSICSTL	DMRTC1;	76	Q5HYR2
SGCLLERRHPPALQP	ANXA2R	141	Q3ZCQ2
LVCPPVHSESRLAQP	CAPRIN1	406	Q14444
AEPHLPEPQLRACEL	CDAN1	1201	Q8IWY9
PICAHGNDDLLPPVD	COBLL1	676	Q53SF7
QSALEPPACEHLPRP	ADAMTS7	916	Q9UKP4
QLLSHEPGDPPCLRR	NUP93	511	Q8N1F7
ECLLHPLPPSADDNL	NPIPB3	371	Q92617
GPTDHLESACPLNLP	RB1	581	P06400
RPHLELLANIDPNPD	RC3H2	351	Q9HBD1
HLELLANIDPSPDAP	RC3H1	356	Q5TC82
IDGSPRLLNTDHPPC	RUBCNL	26	Q9H714
PCNPELTLIAHLPDR	PCK1	211	P35558
LLCPLGSPAEAPFHV	RIC1	11	Q4ADV7
ILPNPHSRVCLTSPD	PTPN5	331	P54829
LLDPPPGSHVIDACA	NSUN5	221	Q96P11
ECLLHPLPPSADDNL	NPIPB12	371	F8W0I5
LPLEVPASQCHRSPL	OTUD7B	336	Q6GQQ9
LRQLPPEAGVSHLCP	FAM47C	366	Q5HY64
LESASSCHRPLLIPP	NOL9	101	Q5SY16
APKPSPLHCLESALR	KRBA1	606	A5PL33
LLELDPPANHTPCVV	KCNJ10	96	P78508
HILAILQDCPSLRPP	POR	426	P16435
CDVHLGNPLAPAVLP	INMT	141	O95050
LRLPCHDFAPAPASV	MST1L	406	Q2TV78
SSQTPPPCLIRRLDH	GLOD5	26	A6NK44
ESPSPPRLLAAHCAL	MNX1	76	P50219
FPSCQPPLSLLLEHL	MTRR	431	Q9UBK8
PLEEDCPPVLSHRSL	FAM13B	511	Q9NYF5
LLNPAAHSADPENPL	ZFPM2	606	Q8WW38
LPSNIDDLPSHEAPL	IL12RB2	801	Q99665
NPELSASHCPEIPAI	GPR50	536	Q13585
RVLPICLPDASIHLP	PRSS22	156	Q9GZN4
PTPEAELLAQPCHDS	HEXIM1	111	O94992
DALPSLQPLPHCSVI	CYP21A2	456	P08686
EHTCPQPRLTLTAPA	PCYT1B	31	Q9Y5K3
LLCRSPAVPDRAHPQ	PLXNB3	1106	Q9ULL4
PRLEVPCSHALPQGL	LGALS12	206	Q96DT0
AGLFPHCLPASRLLP	MTSS1	366	O43312
APQLHPILGPDSCSE	DDIAS	956	Q8IXT1
VNCLEPHPHLPVLAT	DCAF8	481	Q5TAQ9
CQAHPIPDSSPLLQF	FGF21	26	Q9NSA1
AHDALRSDSPPLCPA	NRG2	801	O14511
DQCHHNLSLLPPPTE	GCGR	41	P47871
LPLFLERCPHPVTLA	POLG	411	P54098
LAPNPAERPSLDHLL	PLK5	46	Q496M5
RSTPPHPCSLEDNVI	PMS2P5	106	A8MQ11
ECLLHPLPPSADDNL	NPIPB5	371	A8MRT5
PNQLTPSEPHLCLLD	PLA2G4B	601	P0C869
ECLLHPLPPSADDNL	NPIPB4	371	C9JG80
QPAACEDSLHPVPAA	OC90	421	Q02509
RAECLLHPLPPSADD	NPIPB11	331	E5RHQ5
PHRCPLQDFLRLTEP	ACP2	346	P11117
NLSAASRPVCLPHPE	PRSS36	421	Q5K4E3
PQALATRALPCPAHV	FCHSD1	461	Q86WN1
SADLHPLSELPENRP	DCP1B	301	Q8IZD4
LAALALAREPPAAPC	HTRA3	11	P83110
EIPTHVLPPCANLQA	GFRA1	386	P56159
CHAAPRPNPAQSLKL	C7orf61	186	Q8IZ16
EHLLRPSQVCPQRPL	CGNL1	416	Q0VF96
LPEEPCLPRHPAQLA	FGFR1	801	P11362
GRELCPQHSPLDATP	CACNA1I	521	Q9P0X4
SLLPAVCHHPALPQD	GUCA2B	61	Q16661
RAKDHQPSGPECLPL	CATIP	11	Q7Z7H3
SALPCQASPLHPALA	GLMP	296	Q8WWB7
PCHERPNNVSTLPFL	MBD5	1226	Q9P267
QLQSSLPEPHDRPLA	LY6G5B	111	Q8NDX9
RLCPPHPTARLLLAA	ATAT1	296	Q5SQI0
ATLHNHPLRPSCPLL	DND1	116	Q8IYX4
PGDPQEVRHLNPLLC	LINC02913	111	Q8NAJ2
PPLSSQRPRTLLCHD	ENGASE	116	Q8NFI3
RPDLLPDFHCTLAPV	CAND2	366	O75155
ERCLRFVHPPNASLP	SLC22A8	71	Q8TCC7
RLHPCLVDFHSLPEP	RYR1	901	P21817
SPALRCLEPPHLANL	IZUMO4	206	Q1ZYL8
VPLCRAELNTHRPAP	MAP3K9	1081	P80192
EEPARAVHPLCPSDT	PKD1	396	P98161
ECLLHPLPPSADDNL	NPIPB13	371	A6NJU9
LITCEHVPRASPDDP	PARP10	1001	Q53GL7
AHSPRPLSCLELPSE	ARHGAP30	1041	Q7Z6I6
LPDPHLSKLACVDSP	MAP3K14	296	Q99558
ASSHAVPAPCLPLDQ	MN1	181	Q10571
LPENELLHPPLSICV	FER1L6	1051	Q2WGJ9
HCEAPAEPLPAQAAS	PLEKHM1	351	Q9Y4G2
VPEPDLPCDLRHLNT	STAT2	786	P52630
PHIALFCQENRPSIP	PPP4R1	111	Q8TF05
PQCLDIPADLPLCHT	SFRP5	51	Q5T4F7
ALNLRHCPLEFPPQL	LRRC27	141	Q9C0I9
SLTLDAAPDHNPPCR	NBR1	656	Q14596
LSHPVPCEQPALLRE	NICN1	151	Q9BSH3
VPNSILELPCPHLSA	SEMA4A	571	Q9H3S1
RLLCDAPSNPPAHLS	SIGLEC5	266	O15389
RQSLACPAEPPALPH	SHROOM2	1226	Q13796
HALPPPTINEVRIDC	NPAS3	316	Q8IXF0
PCELEYSPPLHDLRN	ALK	271	Q9UM73
QPPAAARAPCLLLAD	VSX1	91	Q9NZR4
LELARDPQPHCSAGP	UBE2DNL	11	Q8IWF7
VPLPVSDRCFSHLQP	PHF13	81	Q86YI8
VTPALPLQCPTANLH	PHC2	401	Q8IXK0
EHVRLLPHSVCSPNP	ZFHX4	3436	Q86UP3
PLARPEIILNHCAPG	MIXL1	151	Q9H2W2
LGTLPAFLPCELQPH	TLR9	26	Q9NR96
VSLAPCDEPRRTLHP	TNS4	16	Q8IZW8
LVNDPQPEHPLRADL	UBE2L5	111	A0A1B0GUS4
CLEPEARLHPAGPAQ	WDR97	1446	A6NE52
DLSHCPPPPQLRLLD	SUPT20H	251	Q8NEM7
SAHALLLPDDPPCHD	ZNRF4	231	Q8WWF5
PPTGHCLRPLDIEFL	SEPTIN12	166	Q8IYM1
LENSCHRHPLLPPDN	TTLL3	386	Q9Y4R7
RLHLERFIPLATCPP	SNX19	76	Q92543
ALANHAPALPCINPL	TSHZ2	681	Q9NRE2
PNLLPFLRDSTHCPL	VPS41	626	P49754
RPRLSCFHQLLLEPP	PPP6R1	321	Q9UPN7
SLAQPLPADPLCVHN	TLX1	286	P31314
PPQFHPRCSSLGDLL	PLEKHO2	381	Q8TD55
PHKNRLLSPLRCSAP	ZFAND4	466	Q86XD8
CPELHTEPVEPLTRA	WDR91	366	A4D1P6
PEELPLLPCTALVEH	SNAPC2	241	Q13487
PSAFLVPRDPALCQH	USP6	1106	P35125
ECRLDPHLDHPCLPL	TRIM56	191	Q9BRZ2
PHLDHPCLPLAEAVR	TRIM56	196	Q9BRZ2
LVNDPQPEHPLRADL	UBE2L3	111	P68036
HRLPEPSCPQLATLT	TYK2	831	P29597
EHRAAKVPLCPASAP	TTLL13	786	A6NNM8
LTLHRLRIPDFCPPA	DUSP23	56	Q9BVJ7
LRDLPLQHSPEAACP	KCNC4	611	Q03721
CLSPRPEESHLSPEL	KMT2D	841	O14686
LELLPPPRHLSCSHD	GRIN2D	1186	O15399
LPRAHTCFNRLDLPP	NEDD4L	936	Q96PU5