Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Aplasia/Hypoplasia of the phalanges of the hand	DMXL2 ZMPSTE24 TRIO PUF60 POLA1 DVL3 SHH RIPK4 PIGV CHUK MTOR PIGW IHH	1.53e-05	319	53	13	HP:0009767
Domain	Gal_mutarotase_SF_dom	MAN2A1 MAN2B1 GANAB LGI1	6.86e-06	17	141	4	IPR011013
Domain	CRAL_TRIO	TRIO KALRN TTPA SEC14L1	1.69e-05	21	141	4	PF00650
Domain	-	TRIO KALRN TTPA SEC14L1	2.47e-05	23	141	4	3.40.525.10
Domain	SEC14	TRIO KALRN TTPA SEC14L1	3.48e-05	25	141	4	SM00516
Domain	CRAL_TRIO	TRIO KALRN TTPA SEC14L1	4.77e-05	27	141	4	PS50191
Domain	CRAL-TRIO_dom	TRIO KALRN TTPA SEC14L1	5.54e-05	28	141	4	IPR001251
Domain	INTEIN_N_TER	SHH IHH	5.66e-05	2	141	2	PS50817
Domain	Intein_N	SHH IHH	5.66e-05	2	141	2	IPR006141
Domain	ArfGap	ADAP1 AGAP9 ARAP1 ADAP2	6.38e-05	29	141	4	SM00105
Domain	ARFGAP	ADAP1 AGAP9 ARAP1 ADAP2	6.38e-05	29	141	4	PS50115
Domain	ArfGap	ADAP1 AGAP9 ARAP1 ADAP2	6.38e-05	29	141	4	PF01412
Domain	ArfGAP	ADAP1 AGAP9 ARAP1 ADAP2	6.38e-05	29	141	4	IPR001164
Domain	Hedgehog_signalling_dom	SHH IHH	1.69e-04	3	141	2	IPR000320
Domain	HintN	SHH IHH	1.69e-04	3	141	2	SM00306
Domain	HintC	SHH IHH	1.69e-04	3	141	2	SM00305
Domain	Hedgehog	SHH IHH	1.69e-04	3	141	2	IPR001657
Domain	HH_signal	SHH IHH	1.69e-04	3	141	2	PF01085
Domain	Hint	SHH IHH	1.69e-04	3	141	2	PF01079
Domain	Hedgehog_sig/DD-Pept_Zn-bd_dom	SHH IHH	1.69e-04	3	141	2	IPR009045
Domain	Hint_dom	SHH IHH	1.69e-04	3	141	2	IPR001767
Domain	-	SHH IHH	1.69e-04	3	141	2	3.30.1380.10
Domain	Hint_dom_N	SHH IHH	1.69e-04	3	141	2	IPR003587
Domain	Hint_dom_C	SHH IHH	1.69e-04	3	141	2	IPR003586
Domain	CRAL/TRIO_N_dom	TTPA AAR2 SEC14L1	1.79e-04	15	141	3	IPR011074
Domain	Butyrophylin	TRIM43 TRIM27 BTN2A1 TRIM43B TRIM62	1.86e-04	70	141	5	IPR003879
Domain	ConA-like_dom	CALR3 LAMA4 TRIM43 TRIM27 BTN2A1 TRIM43B NRXN1 TRIM62	2.62e-04	219	141	8	IPR013320
Domain	PH	ADAP1 TRIO KALRN DOCK11 RTKN ARHGEF1 AGAP9 ARAP1 ADAP2	2.66e-04	278	141	9	SM00233
Domain	PH_DOMAIN	ADAP1 TRIO KALRN DOCK11 RTKN ARHGEF1 AGAP9 ARAP1 ADAP2	2.73e-04	279	141	9	PS50003
Domain	PH_domain	ADAP1 TRIO KALRN DOCK11 RTKN ARHGEF1 AGAP9 ARAP1 ADAP2	2.81e-04	280	141	9	IPR001849
Domain	Hedgehog/Intein_dom	SHH IHH	3.36e-04	4	141	2	IPR028992
Domain	-	SHH IHH	3.36e-04	4	141	2	2.170.16.10
Domain	SPRY	TRIM43 TRIM27 BTN2A1 TRIM43B TRIM62	5.14e-04	87	141	5	SM00449
Domain	Glyco_hydro_38_C	MAN2A1 MAN2B1	5.58e-04	5	141	2	IPR011682
Domain	Alpha-mann_mid	MAN2A1 MAN2B1	5.58e-04	5	141	2	PF09261
Domain	Ammonium_transpt	RHCE RHD	5.58e-04	5	141	2	IPR001905
Domain	Glyco_hydro_57/38_cen	MAN2A1 MAN2B1	5.58e-04	5	141	2	IPR028995
Domain	Glyco_hydro_38	MAN2A1 MAN2B1	5.58e-04	5	141	2	PF01074
Domain	-	MAN2A1 MAN2B1	5.58e-04	5	141	2	1.20.1270.50
Domain	-	MAN2A1 MAN2B1	5.58e-04	5	141	2	3.20.110.10
Domain	Alpha-mann_mid	MAN2A1 MAN2B1	5.58e-04	5	141	2	SM00872
Domain	Glyco_hydro_38_N	MAN2A1 MAN2B1	5.58e-04	5	141	2	IPR000602
Domain	Glyco_hydro_38/57_N	MAN2A1 MAN2B1	5.58e-04	5	141	2	IPR027291
Domain	Ammonium_transp	RHCE RHD	5.58e-04	5	141	2	PF00909
Domain	NH4_transpt_AmtB-like_dom	RHCE RHD	5.58e-04	5	141	2	IPR024041
Domain	Glyco_hydro_38_cen	MAN2A1 MAN2B1	5.58e-04	5	141	2	IPR015341
Domain	Glyco_hydro_38C	MAN2A1 MAN2B1	5.58e-04	5	141	2	PF07748
Domain	RhesusRHD	RHCE RHD	5.58e-04	5	141	2	IPR002229
Domain	SPRY	TRIM43 TRIM27 BTN2A1 TRIM43B TRIM62	7.32e-04	94	141	5	PF00622
Domain	SPRY_dom	TRIM43 TRIM27 BTN2A1 TRIM43B TRIM62	7.32e-04	94	141	5	IPR003877
Domain	B30.2/SPRY	TRIM43 TRIM27 BTN2A1 TRIM43B TRIM62	7.68e-04	95	141	5	IPR001870
Domain	B302_SPRY	TRIM43 TRIM27 BTN2A1 TRIM43B TRIM62	7.68e-04	95	141	5	PS50188
Domain	Kinase-like_dom	TRIO KALRN TRPM7 CDKL2 NEK7 ACAD10 RIPK4 STK35 CHUK PIK3C3 MTOR PLK4	8.46e-04	542	141	12	IPR011009
Domain	Glyco_hydro/deAcase_b/a-brl	MAN2A1 MAN2B1	1.16e-03	7	141	2	IPR011330
Domain	-	RHCE RHD	1.16e-03	7	141	2	1.10.3430.10
Domain	Ammonium/urea_transptr	RHCE RHD	1.16e-03	7	141	2	IPR029020
Domain	PH	ADAP1 TRIO KALRN DOCK11 RTKN ARAP1 ADAP2	1.79e-03	229	141	7	PF00169
Domain	Cl-channel_core	CLCN4 CLCN6	1.97e-03	9	141	2	IPR014743
Domain	-	CLCN4 CLCN6	1.97e-03	9	141	2	1.10.3080.10
Domain	Voltage_CLC	CLCN4 CLCN6	1.97e-03	9	141	2	PF00654
Domain	Cl-channel_volt-gated	CLCN4 CLCN6	1.97e-03	9	141	2	IPR001807
Domain	-	TRIM43 TRIM27 TRIM43B TRIM62	2.04e-03	71	141	4	4.10.45.10
Domain	-	ADAP1 TRIO KALRN DOCK11 RTKN ARHGEF1 AGAP9 ARAP1 ADAP2	2.92e-03	391	141	9	2.30.29.30
Domain	CRAL_TRIO_N	TTPA SEC14L1	2.98e-03	11	141	2	PF03765
Domain	ZF_BBOX	TRIM43 TRIM27 TRIM43B TRIM62	3.16e-03	80	141	4	PS50119
Domain	Znf_B-box	TRIM43 TRIM27 TRIM43B TRIM62	3.30e-03	81	141	4	IPR000315
Domain	CRAL-bd_toc_tran	TTPA SEC14L1	3.55e-03	12	141	2	IPR001071
Domain	CRAL_TRIO_N	TTPA SEC14L1	3.55e-03	12	141	2	SM01100
Domain	PRY	TRIM27 BTN2A1 TRIM62	3.90e-03	42	141	3	PF13765
Domain	Recoverin	NCALD HPCAL1	4.18e-03	13	141	2	IPR028846
Domain	-	MAN2A1 MAN2B1	4.85e-03	14	141	2	2.60.40.1180
Domain	Ldl_recept_b	LRP1 SORL1	4.85e-03	14	141	2	PF00058
Domain	LDLRB	LRP1 SORL1	4.85e-03	14	141	2	PS51120
Domain	PH_dom-like	ADAP1 TRIO KALRN DOCK11 RTKN ARHGEF1 AGAP9 ARAP1 ADAP2	5.10e-03	426	141	9	IPR011993
Domain	PI3/4_kinase_CS	PIK3C3 MTOR	5.57e-03	15	141	2	IPR018936
Domain	LY	LRP1 SORL1	5.57e-03	15	141	2	SM00135
Domain	Glyco_hydro_b	MAN2A1 MAN2B1	5.57e-03	15	141	2	IPR013780
Domain	LDLR_classB_rpt	LRP1 SORL1	5.57e-03	15	141	2	IPR000033
Domain	PRY	TRIM27 BTN2A1 TRIM62	5.68e-03	48	141	3	SM00589
Domain	PRY	TRIM27 BTN2A1 TRIM62	5.68e-03	48	141	3	IPR006574
Domain	PROTEIN_KINASE_ST	TRIO KALRN CDKL2 NEK7 RIPK4 STK35 CHUK PLK4	6.27e-03	362	141	8	PS00108
Domain	CBS	CLCN4 CLCN6	6.34e-03	16	141	2	SM00116
Domain	GRAM	TBC1D9 GRAMD1B	6.34e-03	16	141	2	SM00568
Domain	-	PIK3C3 MTOR	6.34e-03	16	141	2	1.10.1070.11
Domain	PI3Kc	PIK3C3 MTOR	6.34e-03	16	141	2	SM00146
Pathway	REACTOME_RELEASE_OF_HH_NP_FROM_THE_SECRETING_CELL	SHH ADAM17 IHH	2.25e-05	8	106	3	M27444
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SCN11A NCALD ADAP1 ZMPSTE24 SMIM12 EML6 NUP98 TRIM43 SMC2 TERF2 TRIP12 CHUK AAR2 TRIM43B FRA10AC1 CLCN4 NRXN1 HPCAL1 N4BP2 EMC2	1.60e-06	1442	141	20	35575683
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	TRIO SMC2 TRIP12 TRMT6 PIK3C3 TRIM62 PAN2 UBAC2	2.64e-06	212	141	8	33853758
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	EPG5 GANAB NRXN1 LRP1 CRYBG3	1.07e-05	71	141	5	33541421
Pubmed	High-throughput mapping of a dynamic signaling network in mammalian cells.	SAMD8 SF3A1 RTKN STK35 FCHO1 CHUK ARHGEF1 PLK4	1.18e-05	260	141	8	15761153
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	DMXL2 CATSPERE ADAP1 CYP11A1 BAZ1B RIPK4 TMC3 RHCE RHD CYP2R1 MTOR ARHGEF1 GYS2 ENDOU ADAM17 PRMT3 AGAP9	1.23e-05	1242	141	17	30973865
Pubmed	Organization of the gene (RHCE) encoding the human blood group RhCcEe antigens and characterization of the promoter region.	RHCE RHD	1.63e-05	2	141	2	8188244
Pubmed	Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages.	LRP1 ADAM17	1.63e-05	2	141	2	20610799
Pubmed	Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins.	ADAP1 ADAP2	1.63e-05	2	141	2	14690521
Pubmed	Branched-chain amino acid transaminase 1 (BCAT1) promotes the growth of breast cancer cells through improving mTOR-mediated mitochondrial biogenesis and function.	BCAT1 MTOR	1.63e-05	2	141	2	28235484
Pubmed	Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos.	CALB2 TRIO	1.63e-05	2	141	2	11050238
Pubmed	Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond.	SHH IHH	1.63e-05	2	141	2	28574612
Pubmed	DCS-1, DCS-2, and DFV share amino acid substitutions at the extracellular RhD protein vestibule.	RHCE RHD	1.63e-05	2	141	2	17900276
Pubmed	RHD and RHCE molecular analysis in weak D blood donors and in patients with Rh antibodies against their own corresponding Rh antigen.	RHCE RHD	1.63e-05	2	141	2	32697929
Pubmed	Cholesterol modification of hedgehog signaling proteins in animal development.	SHH IHH	1.63e-05	2	141	2	8824192
Pubmed	Review: the molecular basis of the Rh blood group phenotypes.	RHCE RHD	1.63e-05	2	141	2	15373666
Pubmed	Hedgehog can drive terminal differentiation of amniote slow skeletal muscle.	SHH IHH	1.63e-05	2	141	2	15238161
Pubmed	Heparan sulfate-modulated, metalloprotease-mediated sonic hedgehog release from producing cells.	SHH ADAM17	1.63e-05	2	141	2	19176481
Pubmed	Intron 4 of the RH Gene in Han Chinese, Tibetan, and Mongol Populations.	RHCE RHD	1.63e-05	2	141	2	26579938
Pubmed	Accurate long-read sequencing allows assembly of the duplicated RHD and RHCE genes harboring variants relevant to blood transfusion.	RHCE RHD	1.63e-05	2	141	2	34968422
Pubmed	Regarding the size of Rh proteins.	RHCE RHD	1.63e-05	2	141	2	1898705
Pubmed	PCR screening for common weak D types shows different distributions in three Central European populations.	RHCE RHD	1.63e-05	2	141	2	11161244
Pubmed	RH diversity in Mali: characterization of a new haplotype RHDDIVa/RHCEceTI(D2).	RHCE RHD	1.63e-05	2	141	2	25857637
Pubmed	The low-prevalence Rh antigen STEM (RH49) is encoded by two different RHCEce818T alleles that are often in cis to RHDDOL.	RHCE RHD	1.63e-05	2	141	2	22738288
Pubmed	Multiple Rh messenger RNA isoforms are produced by alternative splicing.	RHCE RHD	1.63e-05	2	141	2	1379850
Pubmed	Characterization of the mouse Rh blood group gene.	RHCE RHD	1.63e-05	2	141	2	10329015
Pubmed	New insight into hedgehog signaling in hematological malignancies.	SHH IHH	1.63e-05	2	141	2	24991722
Pubmed	The Hedgehog signalling pathway mediates drug response of MCF-7 mammosphere cells in breast cancer patients.	SHH IHH	1.63e-05	2	141	2	26201092
Pubmed	Differential requirements for shh in mammary tissue and hair follicle morphogenesis.	SHH IHH	1.63e-05	2	141	2	12217324
Pubmed	Hedgehog signaling regulates expansion of pancreatic epithelial cells.	SHH IHH	1.63e-05	2	141	2	15766752
Pubmed	Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction.	SHH IHH	1.63e-05	2	141	2	29088246
Pubmed	Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle.	ADAP1 ADAP2	1.63e-05	2	141	2	12018390
Pubmed	RHCEceMO is frequently in cis to RHDDAU0 and encodes a hr(S) -, hr(B) -, RH:-61 phenotype in black persons: clinical significance.	RHCE RHD	1.63e-05	2	141	2	23772606
Pubmed	Determination of the N-terminal sequence of human red cell Rh(D) polypeptide and demonstration that the Rh(D), (c), and (E) antigens are carried by distinct polypeptide chains.	RHCE RHD	1.63e-05	2	141	2	3135863
Pubmed	IHH, SHH, and primary cilia mediate epithelial-stromal cross-talk during decidualization in mice.	SHH IHH	1.63e-05	2	141	2	36853961
Pubmed	Sequences and evolution of mammalian RH gene transcripts and proteins.	RHCE RHD	1.63e-05	2	141	2	9811965
Pubmed	Rare RHCE phenotypes in black individuals of Afro-Caribbean origin: identification and transfusion safety.	RHCE RHD	1.63e-05	2	141	2	12393640
Pubmed	Molecular genetic basis of the human Rhesus blood group system.	RHCE RHD	1.63e-05	2	141	2	8220426
Pubmed	Isolation of a new cDNA clone encoding an Rh polypeptide associated with the Rh blood group system.	RHCE RHD	1.63e-05	2	141	2	7916743
Pubmed	RHDDOL1 and RHDDOL2 encode a partial D antigen and are in cis with the rare RHCE*ceBI allele in people of African descent.	RHCE RHD	1.63e-05	2	141	2	22690701
Pubmed	No Distinction of Orthology/Paralogy between Human and Chimpanzee Rh Blood Group Genes.	RHCE RHD	1.63e-05	2	141	2	26872772
Pubmed	Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP.	TRIO KALRN	1.63e-05	2	141	2	26858404
Pubmed	RHCEceTI encodes partial c and partial e and is often in cis to RHDDIVa.	RHCE RHD	1.63e-05	2	141	2	22804620
Pubmed	Intricate combinatorial patterns of exon splicing generate multiple Rh-related isoforms in human erythroid cells.	RHCE RHD	1.63e-05	2	141	2	7789951
Pubmed	The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes.	PIK3C3 MTOR	1.63e-05	2	141	2	21702994
Pubmed	E variants found in Japanese and c antigenicity alteration without substitution in the second extracellular loop.	RHCE RHD	1.63e-05	2	141	2	11724987
Pubmed	The Rh blood group system: a review.	RHCE RHD	1.63e-05	2	141	2	10627438
Pubmed	Opposite expression patterns of Sonic hedgehog and Indian hedgehog are associated with aberrant methylation status of their promoters in colorectal cancers.	SHH IHH	1.63e-05	2	141	2	20854074
Pubmed	Combining hedgehog signaling inhibition with focal irradiation on reduction of pancreatic cancer metastasis.	SHH IHH	1.63e-05	2	141	2	23468532
Pubmed	Polymorphisms in the promoter regions of RHD and RHCE genes in the Chinese Han population.	RHCE RHD	1.63e-05	2	141	2	37823181
Pubmed	Sequence diversity of the Rh blood group system in Basques.	RHCE RHD	1.63e-05	2	141	2	30089826
Pubmed	Transfusion strategy for weak D Type 4.0 based on RHD alleles and RH haplotypes in Tunisia.	RHCE RHD	1.63e-05	2	141	2	29193104
Pubmed	RHCE variants inherited with altered RHD alleles in Brazilian blood donors.	RHCE RHD	1.63e-05	2	141	2	27111588
Pubmed	Alteration of RH gene structure and expression in human dCCee and DCW-red blood cells: phenotypic homozygosity versus genotypic heterozygosity.	RHCE RHD	1.63e-05	2	141	2	8822955
Pubmed	Genetic recombination at the human RH locus: a family study of the red-cell Evans phenotype reveals a transfer of exons 2-6 from the RHD to the RHCE gene.	RHCE RHD	1.63e-05	2	141	2	8808597
Pubmed	Molecular background of Rh D-positive, D-negative, D(el) and weak D phenotypes in Chinese.	RHCE RHD	1.63e-05	2	141	2	12201845
Pubmed	Variant RH alleles and Rh immunisation in patients with sickle cell disease.	RHCE RHD	1.63e-05	2	141	2	24960646
Pubmed	Comprehensive phenotypic and molecular investigation of RhD and RhCE variants in Moroccan blood donors.	RHCE RHD	1.63e-05	2	141	2	30418133
Pubmed	A convenient qualitative and quantitative method to investigate RHD-RHCE hybrid genes.	RHCE RHD	1.63e-05	2	141	2	23550903
Pubmed	Distinct expression patterns of hedgehog ligands between cultured and primary colorectal cancers are associated with aberrant methylation of their promoters.	SHH IHH	1.63e-05	2	141	2	19856079
Pubmed	Molecular cloning and primary structure of the human blood group RhD polypeptide.	RHCE RHD	1.63e-05	2	141	2	1438298
Pubmed	Novel neutralizing hedgehog antibody MEDI-5304 exhibits antitumor activity by inhibiting paracrine hedgehog signaling.	SHH IHH	1.63e-05	2	141	2	24344235
Pubmed	Molecular background of D(C)(e) haplotypes within the white population.	RHCE RHD	1.63e-05	2	141	2	12084172
Pubmed	The analysis of nucleotide substitutions, gaps, and recombination events between RHD and RHCE genes through complete sequencing.	RHCE RHD	1.63e-05	2	141	2	10924335
Pubmed	A two-locus gene conversion model with selection and its application to the human RHCE and RHD genes.	RHCE RHD	1.63e-05	2	141	2	12857961
Pubmed	Specific amino acid substitutions cause distinct expression of JAL (RH48) and JAHK (RH53) antigens in RhCE and not in RhD.	RHCE RHD	1.63e-05	2	141	2	20233350
Pubmed	A recombination hot spot in the Rh genes revealed by analysis of unrelated donors with the rare D-- phenotype.	RHCE RHD	1.63e-05	2	141	2	8900235
Pubmed	RHDweak partial 4.0 is associated with an altered RHCEce(48C, 105T, 733G, 744C, 1025T) allele in the Tunisian population.	RHCE RHD	1.63e-05	2	141	2	23742316
Pubmed	Mesenchymal stromal cells inhibit CD25 expression via the mTOR pathway to potentiate T-cell suppression.	MTOR IL2RA	1.63e-05	2	141	2	28230853
Pubmed	A comprehensive survey of both RHD and RHCE allele frequencies in sub-Saharan Africa.	RHCE RHD	1.63e-05	2	141	2	24033223
Pubmed	Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours.	SHH IHH	1.63e-05	2	141	2	14520411
Pubmed	Increased production of sonic hedgehog by ballooned hepatocytes.	SHH IHH	1.63e-05	2	141	2	21547909
Pubmed	mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.	VPS39 PIK3C3 MTOR	1.81e-05	13	141	3	25533187
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	PDE3B CALR3 ZMPSTE24 TRPM7 NUP98 PEX1 GRAMD1B GANAB ADAM17 EMC2	2.27e-05	468	141	10	31056421
Pubmed	Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.	TRIM43 CHUK TRIM43B	2.86e-05	15	141	3	19703589
Pubmed	Lineage specification of ovarian theca cells requires multicellular interactions via oocyte and granulosa cells.	CYP11A1 SHH IHH	2.86e-05	15	141	3	25917826
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	MAN2A1 ZMPSTE24 MAN2B1 TMEM59 DAG1 LAMA4 NT5DC1 BTN2A1 GRAMD1B GANAB SVIL LRP1 UBAC2 ADAM17 EMC2 SORL1	3.12e-05	1201	141	16	35696571
Pubmed	Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.	MAN2A1 MAN2B1 GANAB	4.25e-05	17	141	3	2355006
Pubmed	Hedgehog signaling maintains resident hepatic progenitors throughout life.	SHH IHH	4.88e-05	3	141	2	16322088
Pubmed	Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels.	SHH IHH	4.88e-05	3	141	2	21537345
Pubmed	[Hedgehog signaling pathway and its impact on development of cancer therapy].	SHH IHH	4.88e-05	3	141	2	18788453
Pubmed	Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation.	SHH IHH	4.88e-05	3	141	2	19109233
Pubmed	Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.	TRIO KALRN	4.88e-05	3	141	2	31801062
Pubmed	The hedgehog signaling pathway in the mouse ovary.	SHH IHH	4.88e-05	3	141	2	17392501
Pubmed	Evolutionary history of the Rh blood group-related genes in vertebrates.	RHCE RHD	4.88e-05	3	141	2	10970100
Pubmed	Insulin activation of vacuolar protein sorting 34 mediates localized phosphatidylinositol 3-phosphate production at lamellipodia and activation of mTOR/S6K1.	PIK3C3 MTOR	4.88e-05	3	141	2	24582588
Pubmed	Conserved evolution of the Rh50 gene compared to its homologous Rh blood group gene.	RHCE RHD	4.88e-05	3	141	2	9705835
Pubmed	Cloning, expression, purification, and characterization of the murine lysosomal acid alpha-mannosidase.	MAN2A1 MAN2B1	4.88e-05	3	141	2	9305783
Pubmed	The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides.	SHH IHH	4.88e-05	3	141	2	11476578
Pubmed	Effects of Melatonin on Early Pregnancy in Mouse: Involving the Regulation of StAR, Cyp11a1, and Ihh Expression.	CYP11A1 IHH	4.88e-05	3	141	2	28749439
Pubmed	Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.	LRP1 SORL1	4.88e-05	3	141	2	28799085
Pubmed	Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα).	CHUK MTOR	4.88e-05	3	141	2	24990947
Pubmed	The members of the RH gene family (RH50 and RH30) followed different evolutionary pathways.	RHCE RHD	4.88e-05	3	141	2	9929383
Pubmed	Genetic mosaic analysis reveals that GATA-4 is required for proper differentiation of mouse gastric epithelium.	SHH IHH	4.88e-05	3	141	2	11784093
Pubmed	Developmental mechanisms underlying polydactyly in the mouse mutant Doublefoot.	SHH IHH	4.88e-05	3	141	2	12587916
Pubmed	Targeting the NF-κB and mTOR pathways with a quinoxaline urea analog that inhibits IKKβ for pancreas cancer therapy.	CHUK MTOR	4.88e-05	3	141	2	23444213
Pubmed	Protein-sequence studies on Rh-related polypeptides suggest the presence of at least two groups of proteins which associate in the human red-cell membrane.	RHCE RHD	4.88e-05	3	141	2	3146980
Pubmed	Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic target.	SHH IHH	4.88e-05	3	141	2	19074837
Pubmed	Evolution of the hedgehog gene family.	SHH IHH	4.88e-05	3	141	2	8849902
Pubmed	Correlation Between Hedgehog (Hh) Protein Family and Brain-Derived Neurotrophic Factor (BDNF) in Autism Spectrum Disorder (ASD).	SHH IHH	4.88e-05	3	141	2	26691363
Pubmed	The adventures of Sonic Hedgehog in development and repair. I. Hedgehog signaling in gastrointestinal development and disease.	SHH IHH	4.88e-05	3	141	2	18063705
GeneFamily	ArfGAPs	ADAP1 AGAP9 ARAP1 ADAP2	2.94e-05	33	98	4	395
GeneFamily	Mannosidases alpha class 2	MAN2A1 MAN2B1	2.88e-04	5	98	2	1194
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ADAP1 DOCK11 RTKN AGAP9 ARAP1 ADAP2	8.97e-04	206	98	6	682
GeneFamily	Chloride voltage-gated channels	CLCN4 CLCN6	1.27e-03	10	98	2	302
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM43 TRIM27 TRIM43B TRIM62	1.77e-03	95	98	4	59
GeneFamily	WD repeat domain containing\|GRAM domain containing\|BEACH domain containing	TBC1D9 GRAMD1B	2.18e-03	13	98	2	1146
ToppCell	droplet-Spleen-nan-24m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHAF1B NCALD B4GALNT4 POLA1 RTKN STK35 TRIM62	2.03e-06	184	141	7	b998803180322a5ea2b567928dea531c26816c3c
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DMXL2 PDE3B BCAT1 GRAMD1B LRP1 ADAM17 ADAP2	2.99e-06	195	141	7	9d649ac7d2af313481069c95349efc0c68449e2b
ToppCell	Adult-Immune\|Adult / Lineage, Cell type, age group and donor	DMXL2 PDE3B DOCK11 GRAMD1B LRP1 DDX60L ADAP2	3.30e-06	198	141	7	9bfd7b88aa646eaf5eddb15cf985c7ca910cb35e
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DMXL2 DOCK11 SVIL LRP1 ADAM17 DDX60L HERC5	3.30e-06	198	141	7	93cc01d91ffc543fd1a717ef47e02e532b50b665
ToppCell	Basal_cells-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	CBLC RIPK4 FBXO2 NRXN1 PTPRR KCNK2	1.01e-05	155	141	6	30accc72a6a914ae0c4d52b373ea1c9a98efbf22
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KALRN PLCXD2 LAMA4 NRXN1 KCNK2 ENDOU	1.35e-05	163	141	6	1e8ab00ecc2d2ba35aa6745c0ed38663e26312e8
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L4-L4_IT_VISp_Rspo1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KALRN PLCXD2 LAMA4 NRXN1 KCNK2 ENDOU	1.35e-05	163	141	6	431221a41d396b09170476179590eaf8a55266d8
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-TRGV4_gdT\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE3B FBXW10 SLC28A3 FBXO2 ZNF547 GID4	1.45e-05	165	141	6	9f6f3a614ac614488e9f59cf2805467ff075ccca
ToppCell	facs-MAT-Fat-18m-Lymphocytic-T_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B4GALNT4 NT5DC1 GRAMD1B LY75 IL2RA PDE11A	1.89e-05	173	141	6	97391a763c17ce0107c9e2386e88c417ac75a72e
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DMXL2 POLA1 SMC2 TBC1D9 LRP1 LY75	2.08e-05	176	141	6	270d7908dbd84028958d257f94941dc685e20255
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCAT1 BCHE SLC28A3 TMPRSS5 RTKN NRXN1	2.22e-05	178	141	6	ef490b45901b2e6dedb519540fa3ae4e4db3a9ba
ToppCell	LPS_only-Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DMXL2 ADAP1 SERPINB10 LRP1 IL2RA ADAP2	2.29e-05	179	141	6	dc03b9045510eb1bb934329646bb92dd06890ce9
ToppCell	LPS_only-Myeloid-Monocytes,_Macrophages\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DMXL2 ADAP1 SERPINB10 LRP1 IL2RA ADAP2	2.29e-05	179	141	6	330c1326ba93bb8f32559ee1cc40e357cc44ad8d
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_3\|368C / Donor, Lineage, Cell class and subclass (all cells)	NCALD ZNF527 BAZ1B CYP2R1 IL2RA ZMYM6	2.44e-05	181	141	6	b193f3606554adc55c5906219d114288bb1f978a
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAG1 BCHE TMPRSS5 RTKN NRXN1 OTOP1	2.52e-05	182	141	6	d568a8aec7e27ce632e248baea2ccd0e8dd255ac
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAG1 BCHE TMPRSS5 RTKN NRXN1 OTOP1	2.52e-05	182	141	6	e89cc30db8e5c77a8bbddd1d5a4b5af09f1ccd67
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 POLA1 SENP8 SMC2 STK35 PLK4	2.67e-05	184	141	6	16aa8e88bdd51b1d132d5cf33c29963b384a8bae
ToppCell	droplet-Limb_Muscle-nan-18m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAP1 BCHE TMPRSS5 EFCAB9 NRXN1 OTOP1	3.20e-05	190	141	6	e2481bd5166fde2cdc0c3824894f2bccb8294fdd
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Chrm2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FBXW10 SHH SLC28A3 EFCAB9	3.21e-05	57	141	4	5ae53d915bee8a5fc7936d2a46517da1b6abbf79
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Chrm2-Inhibitory_Gad1Gad2_Htr3a.Chrm2_(Interneuron,__(candidate_CGE-derived_10))\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FBXW10 SHH SLC28A3 EFCAB9	3.21e-05	57	141	4	e61b10212685e5217550db0812141a1f3f6567c8
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Chrm2-Inhibitory_Gad1Gad2_Htr3a.Chrm2_(Interneuron,__(candidate_CGE-derived_10))-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FBXW10 SHH SLC28A3 EFCAB9	3.21e-05	57	141	4	f5edb5e8eddc51e0b8040e88baa5d8971871f9ea
ToppCell	human_hepatoblastoma-Inflammatory_Monocytes\|World / Sample and Cell Type and Tumor Cluster (all cells)	DMXL2 DOCK11 BCAT1 GRAMD1B DDX60L IL2RA	3.30e-05	191	141	6	3b59bfc6c106ae8a3fbcd4a74bd128c485724921
ToppCell	RV-08._Macrophage\|World / Chamber and Cluster_Paper	DMXL2 DOCK11 BCAT1 FAM111A IL2RA ADAP2	3.39e-05	192	141	6	a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Rorb\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	PLCXD2 RGS22 KCNK2 ENDOU ADGRF4	3.41e-05	116	141	5	9c92e714e210a2f29a9e228653d4c990ec643c72
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	PDE3B MAN2A1 DAG1 GANAB N4BP2 CRYBG3	3.49e-05	193	141	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	Striatum-Macroglia-CSF_related-EPENDYMAL-Ependyma_Ccdc153.Ccdc153_(Ccdc153)-\|Striatum / BrainAtlas - Mouse McCarroll V32	LRRC34 FBXW10 RGS22 SLC28A3 SERPINB10	3.56e-05	117	141	5	26dec09112532f351fb7a2202bae84c365707b40
ToppCell	Striatum-Macroglia-CSF_related-EPENDYMAL-Ependyma_Ccdc153.Ccdc153_(Ccdc153)\|Striatum / BrainAtlas - Mouse McCarroll V32	LRRC34 FBXW10 RGS22 SLC28A3 SERPINB10	3.56e-05	117	141	5	db053c874e6739052dff1f91643e51b306236237
ToppCell	Striatum-Macroglia-CSF_related-EPENDYMAL-Ependyma_Ccdc153.Ccdc153_(Ccdc153)--\|Striatum / BrainAtlas - Mouse McCarroll V32	LRRC34 FBXW10 RGS22 SLC28A3 SERPINB10	3.56e-05	117	141	5	80780223502d18f0d86a29ff3cb74aa8235103c7
ToppCell	Striatum-Macroglia-CSF_related-EPENDYMAL\|Striatum / BrainAtlas - Mouse McCarroll V32	LRRC34 FBXW10 RGS22 SLC28A3 SERPINB10	3.56e-05	117	141	5	40889f4a387846abbf54469cc4faf616bfe348d0
ToppCell	Striatum-Macroglia-CSF_related\|Striatum / BrainAtlas - Mouse McCarroll V32	LRRC34 FBXW10 RGS22 SLC28A3 SERPINB10	3.56e-05	117	141	5	e12e37e393257db85f7f5c13454095c44f59d374
ToppCell	(6)_Endothelial_cells-(6)_Endothelial-F_(Lymphatics)\|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	CHAF1B LAMA4 BCAT1 BCHE FBXO2 BHMT2	3.60e-05	194	141	6	9441202d6fa2ffbef9277d48ae9bc98876c26ec5
ToppCell	droplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DMXL2 CHAF1B POLA1 SMC2 TBC1D9 PLK4	3.70e-05	195	141	6	c1435e61e4f0cf457f26ae436936048932ceb0db
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DMXL2 DOCK11 GRAMD1B SAMD9L LRP1 DDX60L	4.03e-05	198	141	6	e125eb8aa57c172e5518874da1bd25998292f5e2
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NCALD KALRN EML6 NRXN1 PTPRR CACNA2D3	4.03e-05	198	141	6	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-DN_to_DP_transition,_dividing_(more_DN)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHAF1B POLA1 HAT1 BCAT1 SMC2 PLK4	4.03e-05	198	141	6	c78ff8fc71dfcba1ac0c373bc90ea7b87c5699a4
ToppCell	Sepsis-Bac-SEP-Myeloid-tDC\|Bac-SEP / Disease, condition lineage and cell class	TRIO BAZ1B PIGW PRMT3 CRYBG3 CACNA2D3	4.14e-05	199	141	6	a2be40d367338d32348a6906c8475aa3b544a0f7
ToppCell	COVID-19-lung\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DMXL2 PDE3B DOCK11 SAMD9L LRP1 ARAP1	4.14e-05	199	141	6	155b03b859157013e9142e9248551369127d9204
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	EML6 HAT1 BCHE RIPK4 ETV3L TAF2	4.26e-05	200	141	6	9b614b8b949aa7d3ddbe613db6e08adaf04535a7
ToppCell	mild-Non-classical_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DMXL2 BCAT1 SVIL LRP1 ARAP1 ADAP2	4.26e-05	200	141	6	334bab6bf93d455f3526e817ea5785d8b6ee531c
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Fezf2-Excitatory_Neuron.Slc17a7-Slc17a6.Fezf2-3110035E14Rik_(Layer_5,_Retrosplenial_cortex_(RSG)_and_Subiculum,_Tshz2+)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TRIM43 RIPK4 TMC3 EFCAB9	8.97e-05	74	141	4	83b762542508f9d6407e4b0087d70bea81a8fc7d
Drug	beta- Belladonnine dichloroethylate [191355-47-2]; Down 200; 6uM; PC3; HT_HG-U133A	SCN11A SF3A1 NUP98 PEX1 BAZ1B FBXO2 CLCN4 PTPRR SORL1	3.80e-06	196	141	9	6638_DN
Drug	Nalidixic acid sodium salt hydrate; Up 200; 14.6uM; PC3; HT_HG-U133A	SCN11A FMO4 TRIO FBXO2 CLCN6 ZNF606 INPP5J ARAP1 PDE11A	4.30e-06	199	141	9	7367_UP
Disease	Anemia, Hemolytic, Congenital	RHCE RHD	2.05e-05	2	134	2	C0002881
Disease	Rh Deficiency Syndrome	RHCE RHD	6.12e-05	3	134	2	C0272052
Disease	Rh-Null, Regulator Type	RHCE RHD	6.12e-05	3	134	2	C1849387
Disease	Malignant neoplasm of breast	UTS2R CATSPERE KALRN VPS39 NOA1 NUP98 DVL3 BCHE CUBN RHD EPG5 MTOR N4BP2 ADGRF4 SORL1	1.14e-04	1074	134	15	C0006142
Disease	ADP-ribosylation factor-like protein 11 measurement	BCHE CUBN	1.22e-04	4	134	2	EFO_0801355
Disease	Unipolar Depression	KALRN PTPRR MTOR KCNK2 LRP1 IL2RA PDE11A	1.88e-04	259	134	7	C0041696
Disease	primary progressive multiple sclerosis (is_marker_for)	SHH BCHE	3.03e-04	6	134	2	DOID:0050784 (is_marker_for)
Disease	Hyperphosphatasia-intellectual disability syndrome	PIGV PIGW	3.03e-04	6	134	2	cv:C1855923
Disease	coffee consumption	NCALD BAZ1B ACAD10	4.12e-04	32	134	3	EFO_0004330
Disease	Hyperphosphatasia with Mental Retardation	PIGV PIGW	4.24e-04	7	134	2	C1855923
Disease	platelet reactivity measurement, thrombus formation measurement	N4BP2 SVIL	4.24e-04	7	134	2	EFO_0004985, EFO_0007615
Disease	autism spectrum disorder (is_marker_for)	SHH IHH	4.24e-04	7	134	2	DOID:0060041 (is_marker_for)
Disease	muscular atrophy (implicated_via_orthology)	CHUK MTOR	4.24e-04	7	134	2	DOID:767 (implicated_via_orthology)
Disease	Todd Paralysis	TRPM7 BCHE	7.22e-04	9	134	2	C0234544
Disease	Paralysed	TRPM7 BCHE	7.22e-04	9	134	2	C0522224
Disease	primary bacterial infectious disease (implicated_via_orthology)	SHH IHH	7.22e-04	9	134	2	DOID:0050338 (implicated_via_orthology)
Disease	N6,N6-dimethyllysine measurement	FRA10AC1 LGI1	7.22e-04	9	134	2	EFO_0800100
Disease	Major Depressive Disorder	KALRN PTPRR MTOR LRP1 IL2RA PDE11A	8.75e-04	243	134	6	C1269683
Disease	axin-2 measurement	BCHE IGHG1	8.99e-04	10	134	2	EFO_0801400
Disease	epilepsy (implicated_via_orthology)	SCN11A TRIO KALRN LRP1 LGI1	9.10e-04	163	134	5	DOID:1826 (implicated_via_orthology)
Disease	coronary artery disease (is_implicated_in)	KALRN BCHE CUBN CLCN6	1.14e-03	100	134	4	DOID:3393 (is_implicated_in)
Disease	Parkinson Disease, Secondary Vascular	SHH BCHE	1.31e-03	12	134	2	C0751414
Disease	Atherosclerotic Parkinsonism	SHH BCHE	1.31e-03	12	134	2	C0751415
Disease	Secondary Parkinson Disease	SHH BCHE	1.31e-03	12	134	2	C0030569
Disease	asthma, chronic obstructive pulmonary disease	METTL4 UBAC2 IL2RA	1.54e-03	50	134	3	EFO_0000341, MONDO_0004979
Disease	Hypermetropia, Myopia	CUBN NT5DC1 GRAMD1B CACNA2D3 PDE11A	1.75e-03	189	134	5	HP_0000540, HP_0000545
Disease	basal cell carcinoma	RGS22 SMC2 STK35 UBAC2 IL2RA	1.75e-03	189	134	5	EFO_0004193
Disease	beta-amyloid 1-42 measurement, cerebrospinal fluid biomarker measurement	FRA10AC1 LGI1	1.80e-03	14	134	2	EFO_0004670, EFO_0006794
Disease	keratinocyte carcinoma	RGS22 SMC2 STK35 UBAC2	2.09e-03	118	134	4	EFO_0010176
Disease	body mass index, type 2 diabetes mellitus	MTOR ARAP1	2.36e-03	16	134	2	EFO_0004340, MONDO_0005148
Disease	pursuit maintenance gain measurement	TMPRSS5 EPG5 PRMT3 DDX60L	2.43e-03	123	134	4	EFO_0008433
Disease	cystatin C measurement	KALRN SHH BAZ1B ACAD10 SENP8 DNAH1 LRP1	2.47e-03	402	134	7	EFO_0004617
Disease	Multiple congenital anomalies	CHUK NRXN1	2.66e-03	17	134	2	C0000772
Disease	Alzheimer's disease (is_implicated_in)	BCHE LRP1 ADAM17 SORL1	3.14e-03	132	134	4	DOID:10652 (is_implicated_in)
Disease	myocardial infarction (implicated_via_orthology)	SHH DAG1 MTOR	3.40e-03	66	134	3	DOID:5844 (implicated_via_orthology)
Disease	diet measurement, body mass index	FRA10AC1 LGI1	3.69e-03	20	134	2	EFO_0004340, EFO_0008111
Disease	platelet crit	SMIM12 KALRN DAG1 CUBN STK35 RHCE RHD EPG5 SVIL LY75 SORL1	4.18e-03	952	134	11	EFO_0007985
Disease	chronic obstructive pulmonary disease	NCALD SHH BCHE ACAD10 METTL4 BTN2A1 TRIM62 SVIL CACNA2D3	4.27e-03	688	134	9	EFO_0000341
Disease	serum IgM measurement	GRAMD1B UBXN7	4.46e-03	22	134	2	EFO_0004993
Disease	total blood protein measurement	LRRC34 SLC28A3 TMPRSS5 DNAH1 PTPRR IL2RA ARAP1	4.53e-03	449	134	7	EFO_0004536

Protein segments in the cluster

Peptide	Gene	Start	Entry
YHEFQETVGLWTQAK	EPG5	1456	Q9HCE0
DHKAFYVLFTWDQEA	ARHGEF1	721	Q92888
EFGKESILFHYTDWV	BCHE	391	P06276
FWTEVYQDKVGLTHE	AGAP9	101	Q5VTM2
DLAHQWGEFKVSERY	BCAT1	296	P54687
NFIVWEIHGRDDYSF	CATSPERE	781	Q5SY80
CEIKGWEAVSIYQFH	CBLC	391	Q9ULV8
VYFQEEFLDGEHWRN	CALR3	21	Q96L12
WVAYEKEHFKGQQFL	CRYBG3	2526	Q68DQ2
GLFIEKGWVHDSIDY	BAZ1B	921	Q9UIG0
WFLKEVTDHADGKYV	GYS2	161	P54840
DGKYVVAQFHEWQAG	GYS2	171	P54840
FQFEHIKWQYAVEKT	FBXW10	681	Q5XX13
CFLLGNVYEAFEHWK	AAR2	261	Q9Y312
WFIIGSHFNIKAQDY	ADGRF4	456	Q8IZF3
ELGDFYLELHWDFQS	ANKRD13C	221	Q8N6S4
IFNEHKSYVQGVTWD	CHAF1B	166	Q13112
IREEDSFYVINGHKW	ACAD10	811	Q6JQN1
YHEDGKEIVDWFNAL	ADAP1	211	O75689
WVADAFGKEGIYEAH	CLCN4	561	P51793
YAQWKHAVKFGDTEA	DMXL2	1271	Q8TDJ6
AFIGSDVVDWLYHNV	DVL3	441	Q92997
IEKNFWSGLEDYFRH	GRAMD1B	516	Q3KR37
LFVYHESGKEIVDWF	ADAP2	211	Q9NPF8
AWKGIAHKYEFDLAF	ITPRIP	311	Q8IWB1
EHFWGEKNHGFEVLY	FCHO1	6	O14526
AWYFLDLKIQGETHD	PAN2	1121	Q504Q3
LGVAVIHDYADWVKE	NUP98	1241	P52948
FSHIYIWGNKFDEAT	LRRC34	381	Q8IZ02
FDFWKDIVAAIQHNY	NT5DC1	156	Q5TFE4
AKDWVVVDYGTRLFH	MAN2A1	576	Q16706
VWAEAVHYVSGLKED	CHUK	426	O15111
GIDFHAENDTIYWVD	LRP1	1926	Q07954
KHIEGWSALDAIYFV	KCNK2	246	O95069
NHIDRVDAWVGTYFE	DAG1	501	Q14118
FKWGQNLHFFYLVEC	DDX60L	56	Q5H9U9
LDWNAVGEIDFEKFY	EFCAB9	71	A8MZ26
LKSWEVNFGYIEHGE	FRA10AC1	186	Q70Z53
GGVEEERDHWQQFYF	FBXO2	101	Q9UK22
FVRFEHGGQDSVYWK	FBXO2	266	Q9UK22
EFFELVSKGEYDWNI	PDE11A	786	Q9HCR9
DLHLKWTEGIVNEFY	PDE3B	946	Q13370
ERIHENGYNFKSDIW	NEK7	206	Q8TDX7
VTGFHNWIRFYLEEK	ENDOU	296	P21128
KFWDYLQEFAEHFDL	FMO4	86	P31512
EFTDHELQEWYKGFL	HPCAL1	21	P37235
QIYDWHKDFFLAELE	KALRN	1981	O60229
LIIEGSEYWFVADLH	LY75	816	O60449
LLKKVNDGEWYHVDF	NRXN1	566	Q9ULB1
LVKGADEEQVFHFYW	POLA1	331	P09884
QHEADKIWSKEGFYA	PTPRR	216	Q15256
DVDRKHWGKFLAFYQ	GID4	196	Q8IVV7
DNFEEVFYIHFNVHW	HERC5	826	Q9UII4
VIYIEEAHASDGWAF	DIO1	151	P49895
VYFLWGHAKDIIQSF	OTOP1	181	Q7RTM1
WYLVFEFVDHTILDD	CDKL2	76	Q92772
DVGYVHDVNCFWVIK	CUBN	491	O60494
VPKYHFWEQKEDFTF	DNAH1	486	Q9P2D7
WTGDFFNKGIYDIHV	CLCN6	566	P51797
FIDVDDERWHYFLVF	HAT1	191	O14929
WKNVDFLIAEYFEHV	BHMT2	141	Q9H2M3
FLIAEYFEHVEEAVW	BHMT2	146	Q9H2M3
DWHVVNYKYEDFSGD	DOCK11	111	Q5JSL3
HADRIAFWDDVYGFK	PRMT3	376	O60678
DKENIFNADHFPLWY	CACNA2D3	756	Q8IZS8
SVHFDEKYWRDPEVF	CYP2R1	406	Q6VVX0
ETNYFFVEPWFEIHN	FAM111A	421	Q96PZ2
HVAAWDVIFSKADIY	CYP11A1	266	P05108
FASGKHYWEVEVENV	BTN2A1	381	Q7KYR7
WENEATERIYHFVVG	IL2RA	131	P01589
THDDVGWLKTVDQYF	MAN2B1	71	O00754
FLEIWKHFDADGNGY	CALB2	21	P22676
VKFNWYVDGVEVHNA	IGHG1	156	P01857
TGAINGDVYVWKDHF	EML6	1571	Q6ZMW3
FVGDQEAWHELAELY	EMC2	151	Q15006
KEEFRHVIAWQQGEY	ETV3L	51	Q6ZN32
YVHDVSFWIDQKKGF	FDXACB1	536	Q9BRP7
WSLYNTFVIEEKHGF	ZMPSTE24	141	O75844
WDFDVCKGDIVFNIY	SEC14L1	551	Q92503
DFTEHEIQEWYKGFL	NCALD	21	P61601
AIHVFPWDQEYFDVE	PEX1	311	O43933
SWGNEVLKFQHVDYF	METTL4	451	Q8N3J2
VELTAQDVKDAHWFY	NOA1	481	Q8NC60
VEAGFDWVYYESKAH	IHH	171	Q14623
EKYNDGLWHDVIFIR	LAMA4	1546	Q16363
PQWYRHTFEEAEKGF	MTOR	231	P42345
EYFKNKGDLHRWAVF	RTKN	136	Q9BST9
NGYVVNLFWAFDTHK	SORL1	1776	Q92673
LQNLHWKVSVEFEGY	TRMT1L	141	Q7Z2T5
FIAGRHYWEVEVGDK	TRIM27	366	P14373
VFSFGKHYWELDVDN	TRIM43	331	Q96BQ3
VHYKSWNEDFEGHLE	TMC3	991	Q7Z5M5
VEAGFDWVYYESKAH	SHH	166	Q15465
WFAGRKVVAEVYDQE	PUF60	536	Q9UHX1
VFDFGSEVYVWHGKE	SVIL	1596	O95425
SIGQFHEGDAYVVKW	SVIL	1771	O95425
HVAVWLKDEGFFEYV	SAMD8	16	Q96LT4
WDNVPAEYKHFKFSD	RGS22	841	Q8NE09
HFYIKEKDFNTALDW	SAMD9L	1091	Q8IVG5
FGVNEYRHWIKEELD	TAF2	386	Q6P1X5
IWLDIEHADGKRYFT	GANAB	426	Q14697
FAAVVEQIHKFAQYW	PIK3C3	871	Q8NEB9
FFNEFVAYEHLSKWI	SLC28A3	516	Q9HAS3
ADFEVWFYDGVKIHK	PLK4	721	O00444
WFYDGVKIHKTEDFI	PLK4	726	O00444
KERVAYAQIDWHDFV	SF3A1	266	Q15459
DTKHDVYSFAIVIWG	RIPK4	201	P57078
EYGVHWNFFFTIIVV	PIGW	231	Q7Z7B1
EYKGQVNLHVFEDWC	B4GALNT4	116	Q76KP1
EYTVKWQDFFTGHVV	ADAM17	106	P78536
EWFATFLFVQHDGLV	ARAP1	1386	Q96P48
YVAYVWAKHEDVDGN	INPP5J	786	Q15735
WDAEHFLFIAEHGYL	PIGV	66	Q9NUD9
WTFYLQADDGKIVIF	TMEM59	166	Q9BXS4
VWEGHYTAKADIFAL	STK35	426	Q8TDR2
PHEAKYFDDQVFWKF	RHD	396	Q02161
YFDDQVFWKFPHLAV	RHD	401	Q02161
PHVAKYFDDQVFWKF	RHCE	396	P18577
YFDDQVFWKFPHLAV	RHCE	401	P18577
QEIYFIHGLFGIKVW	PLCXD2	126	Q0VAA5
EQAWKIHFAEYGQGI	TBC1D9	486	Q6ZT07
GVYAKVAEFLDWIHD	TMPRSS5	436	Q9H3S3
WLNDHIIGFAFEYFA	SENP8	26	Q96LD8
HWDPKVFTAYDVFRV	TTPA	121	P49638
KDYDWINAERHLFGQ	SMC2	936	O95347
AFVVGAVGYHLEWFI	SMIM12	21	Q96EX1
TFEKQWFYLDNVIGH	TRMT6	46	Q9UJA5
FIVATYVTKEWHFGD	UTS2R	106	Q9UKP6
AKYFHDEEWVGKLAY	ZMYM6	1101	O95789
VAIYFSQEEWGHLDE	ZNF547	16	Q8IVP9
EDVAIYFSQEEWGHL	ZNF548	11	Q8NEK5
FIFWQVYHDSEEGQR	UBXN7	201	O94888
FYEVWEKFDPEATQF	SCN11A	1626	Q9UI33
VFSFGKHYWELDVDN	TRIM43B	331	A6NCK2
FVYDLHAVKNDFQIW	UBAC2	41	Q8NBM4
GWIKEQAHKFVERYF	TRIP12	1091	Q14669
FSSGVHYWEVVVAEK	TRIM62	346	Q9BVG3
YRGGFHEDQWEKEFE	TTC4	26	O95801
QLWHDKIDFVISEYG	TSPAN19	116	P0C672
ALYFKGIWEHQFLVQ	SERPINB10	186	P48595
EEAVNRWVLKFYFHE	TERF2	91	Q15554
AWDRVDIAKNHVFVY	TRPM7	416	Q96QT4
QIYDWHRDFFLGELE	TRIO	2021	O75962
EWEKVFGYDSFLTQH	ZNF606	376	Q8WXB4
LYFWKDREFHELQGD	VPS39	146	Q96JC1
FREAWKYKGEFELHQ	ZNF527	126	Q8NB42
IFLEWDHVEKTFRNY	LGI1	261	O95970
QYQFDVKYLGEAHEW	N4BP2	481	Q86UW6