Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	azurophil granule lumen	MPO UNC13D ARG1 ARSB NAPRT	7.97e-05	91	101	5	GO:0035578
MousePheno	Rathke's pouch hypoplasia	CHD7 WDR11	2.84e-05	2	75	2	MP:0013350
MousePheno	abnormal tail morphology	FRAS1 MIS18BP1 DIS3L2 DACT1 ARSB WDR11 TMEM132A AEBP2 DCHS1 DOT1L	5.52e-05	403	75	10	MP:0002111
MousePheno	abnormal neurohypophysis median eminence morphology	CHD7 WDR11	8.49e-05	3	75	2	MP:0009229
MousePheno	abnormal optic eminence morphology	CHD7 WDR11	8.49e-05	3	75	2	MP:0006305
Domain	NA_SOLUT_SYMP_1	SLC5A1 SLC5A11 SLC5A6	2.31e-05	11	99	3	PS00456
Domain	SSF	SLC5A1 SLC5A11 SLC5A6	3.07e-05	12	99	3	PF00474
Domain	NA_SOLUT_SYMP_2	SLC5A1 SLC5A11 SLC5A6	3.07e-05	12	99	3	PS00457
Domain	Na/solute_symporter	SLC5A1 SLC5A11 SLC5A6	3.07e-05	12	99	3	IPR001734
Domain	NA_SOLUT_SYMP_3	SLC5A1 SLC5A11 SLC5A6	3.07e-05	12	99	3	PS50283
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SEMA3F FRAS1 GBF1 ZNF395 TFE3 SBNO2 MAP3K5 FAM83H DACT1 MEGF8 MTMR14 NAPRT TMEM132A DOT1L D2HGDH	7.16e-07	1105	101	15	35748872
Pubmed	Infantile hemangioma-derived stem cells and endothelial cells are inhibited by class 3 semaphorins.	SEMA3F SEMA3E	8.35e-06	2	101	2	26086095
Pubmed	Role of class 3 semaphorins in the development and maturation of the septohippocampal pathway.	SEMA3F SEMA3E	2.50e-05	3	101	2	15386596
Pubmed	RINL, guanine nucleotide exchange factor Rab5-subfamily, is involved in the EphA8-degradation pathway with odin.	RINL ANKS1A	2.50e-05	3	101	2	22291991
Pubmed	Apoptosis signal-regulating kinase 1 regulates the expression of caspase-11.	CASP4 MAP3K5	2.50e-05	3	101	2	19695249
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	ENTPD7 POMT2 SEMA3F ABCC1 FRAS1 SUN1 ATF6B BTN2A1 COL18A1 MEGF8 P3H1 SLC5A6 TMEM132A	4.55e-05	1201	101	13	35696571
Pubmed	A semaphorin code defines subpopulations of spinal motor neurons during mouse development.	SEMA3F ETV4 SEMA3E	4.60e-05	24	101	3	15869472
Pubmed	Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells.	DCHS2 DCHS1	4.99e-05	4	101	2	35420656
Pubmed	Calcium Ion Chelation Preserves Platelet Function During Cold Storage.	UNC13D GP1BA	4.99e-05	4	101	2	33176450
Pubmed	A pooling-based genome-wide analysis identifies new potential candidate genes for atopy in the European Community Respiratory Health Survey (ECRHS).	MAP3K5 COL18A1	4.99e-05	4	101	2	19961619
Pubmed	Epistasis of oxidative stress-related enzyme genes on modulating the risks in oral cavity cancer.	MPO GPX1	4.99e-05	4	101	2	20643115
Pubmed	Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency	CHD7 WDR11 SEMA3E	7.39e-05	28	101	3	20301509
Pubmed	Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells.	SEMA3F SEMA3E	8.30e-05	5	101	2	18818766
Pubmed	Mouse CCDC79 (TERB1) is a meiosis-specific telomere associated protein.	SUN1 SMC1B	8.30e-05	5	101	2	24885367
Pubmed	KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability.	SLC5A1 SLC5A11	8.30e-05	5	101	2	24595108
Pubmed	Genotype versus phenotype: conflicting results in mapping a lung tumor susceptibility locus to the G7c recombination interval in the mouse MHC class III region.	VWA7 VARS1	1.24e-04	6	101	2	11797099
Pubmed	DNA Damage Regulates Translation through β-TRCP Targeting of CReP.	ZNF395 DACT1 AEBP2	1.45e-04	35	101	3	26091241
Pubmed	Molecular analysis of the major MHC recombinational hot spot located within the G7c gene of the murine class III region that is involved in disease susceptibility.	VWA7 VARS1	1.74e-04	7	101	2	9551980
Pubmed	Dysfunctional SEMA3E signaling underlies gonadotropin-releasing hormone neuron deficiency in Kallmann syndrome.	CHD7 SEMA3E	1.74e-04	7	101	2	25985275
Pubmed	Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system.	HJV ETV4	1.74e-04	7	101	2	14749425
Pubmed	Pool-specific regulation of motor neuron survival by neurotrophic support.	ETV4 SEMA3E	1.74e-04	7	101	2	21813676
Pubmed	ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming.	CASP4 MAP3K5	1.74e-04	7	101	2	29353059
Pubmed	Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.	DCHS2 DCHS1	1.74e-04	7	101	2	16059920
Pubmed	Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway.	MPO GPX1	2.31e-04	8	101	2	15829318
Pubmed	Semaphorins III and IV repel hippocampal axons via two distinct receptors.	SEMA3F SEMA3E	2.31e-04	8	101	2	9753685
Pubmed	Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.	UNC13D OTOF	2.31e-04	8	101	2	25609709
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	FBF1 MSANTD4 HHIPL1 DOT1L	2.75e-04	107	101	4	11347906
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	GBF1 CASP4 TFE3 CCNY PASK CLK3 GID8 BCAR3 D2HGDH VARS1 EPB41 ANKS1A	3.52e-04	1284	101	12	17353931
Pubmed	Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma.	MPO GPX1	3.70e-04	10	101	2	16543247
Pubmed	Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects.	PTPN22 CCNY	3.70e-04	10	101	2	20176734
Pubmed	Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins.	SEMA3F SEMA3E	3.70e-04	10	101	2	15550623
Pubmed	Genetic polymorphisms in the oxidative stress pathway and susceptibility to non-Hodgkin lymphoma.	MPO GPX1	3.70e-04	10	101	2	17149600
Pubmed	Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.	GPX1 PTPN22 CCNY SBNO2	3.74e-04	116	101	4	21102463
Pubmed	The DNA sequence and analysis of human chromosome 6.	DDR1 VWA7 ATF6B BTN2A1 MAP3K5 ARG1 VARS1 ANKS1A	4.71e-04	622	101	8	14574404
Pubmed	Establishment and Dysfunction of the Blood-Brain Barrier.	ABCC1 SLC5A1 SLC5A6	4.74e-04	52	101	3	26590417
Pubmed	New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation.	SEMA3F SEMA3E	5.41e-04	12	101	2	29358640
Pubmed	Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting.	SEMA3F SEMA3E	5.41e-04	12	101	2	19812329
Pubmed	Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons.	SEMA3F SEMA3E	5.41e-04	12	101	2	23991118
Pubmed	Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.	GBF1 NRDC ZNF395 AEBP2	5.42e-04	128	101	4	25332235
Pubmed	Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.	VWA7 ATF6B VARS1	5.59e-04	55	101	3	14656967
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	GBF1 ZNF395 FAM83H WDR11 AEBP2	5.96e-04	232	101	5	25515538
Pubmed	Adrenergic Signaling in Muscularis Macrophages Limits Infection-Induced Neuronal Loss.	CASP4 ARG1	6.38e-04	13	101	2	31923400
Pubmed	Met signaling is required for recruitment of motor neurons to PEA3-positive motor pools.	ETV4 SEMA3E	6.38e-04	13	101	2	12948444
Pubmed	Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development.	CHD7 MAP3K5	6.38e-04	13	101	2	23319608
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	GBF1 FBF1 PTPN22 VWA7 OTOF RBM15B	6.64e-04	361	101	6	26167880
Pubmed	Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.	SEMA3F ABCC1 SUN1 USP20	8.00e-04	142	101	4	19851296
Pubmed	Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.	SEMA3F GLB1L ATF6B COL18A1 SEMA3E	8.04e-04	248	101	5	24006456
Pubmed	Association of genetic variants with hemorrhagic stroke in Japanese individuals.	SEMA3F ABCC1 SUN1 USP20	8.21e-04	143	101	4	20198315
Pubmed	Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors.	MPO GPX1	8.55e-04	15	101	2	19505917
Pubmed	Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice.	ETV4 CHD7	8.55e-04	15	101	2	19855134
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	GBF1 TFE3 CCNY CLK3 ANKS1A	9.10e-04	255	101	5	15324660
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	CABP1 MIS18BP1 GBF1 FBF1 CHD7 USP20 CAPN11 CYP2R1 SLC5A6 CCDC106 DOT1L	9.73e-04	1242	101	11	30973865
Pubmed	Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.	CCNY SBNO2	9.76e-04	16	101	2	19068216
Pubmed	Pharmacogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: the Scottish Randomised Trial in Ovarian Cancer.	MPO ABCC1	9.76e-04	16	101	2	17925548
Pubmed	Expression of the semaphorins Sema 3D and Sema 3F in the developing parathyroid and thymus.	SEMA3F SEMA3E	9.76e-04	16	101	2	18489001
Pubmed	Balance between BDNF and Semaphorins gates the innervation of the mammary gland.	SEMA3F SEMA3E	9.76e-04	16	101	2	30628891
Pubmed	A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development.	CHD7 SEMA3E	1.10e-03	17	101	2	26102480
Pubmed	Semaphorin signaling facilitates cleft formation in the developing salivary gland.	SEMA3F SEMA3E	1.10e-03	17	101	2	17626059
Pubmed	Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.	DNHD1 DOT1L	1.10e-03	17	101	2	12693554
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	NRDC SUN1 UNC13D CHD7 SBNO2 COL18A1 AEBP2 ITPRIP DOT1L D2HGDH	1.23e-03	1084	101	10	11544199
Pubmed	Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development.	DCHS2 DCHS1	1.24e-03	18	101	2	33108146
Pubmed	Genetic polymorphisms in nitric oxide synthase genes modify the relationship between vegetable and fruit intake and risk of non-Hodgkin lymphoma.	MPO GPX1	1.24e-03	18	101	2	19423521
Pubmed	Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.	DDR1 GPX1 MAP3K5 CLK3 DOT1L	1.29e-03	276	101	5	28319085
Pubmed	Neurites from trigeminal ganglion explants grown in vitro are repelled or attracted by tooth-related tissues depending on developmental stage.	SEMA3F SEMA3E	1.38e-03	19	101	2	15051154
Pubmed	Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry.	MAP3K5 SLC5A1	1.38e-03	19	101	2	12543931
Pubmed	VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm.	SEMA3F SEMA3E	1.53e-03	20	101	2	21658587
Pubmed	Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction.	MPO ARG1	1.53e-03	20	101	2	26358260
Pubmed	Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity.	SEMA3F SEMA3E	1.69e-03	21	101	2	36240771
Pubmed	A genome annotation-driven approach to cloning the human ORFeome.	NDUFA6 RFPL1 PEX26 SLC5A1 SELENOO	1.71e-03	294	101	5	15461802
Pubmed	Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation.	NDST4 ETV4 COL18A1	1.72e-03	81	101	3	39217171
Pubmed	High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.	DDR1 VWA7 ATF6B VARS1	1.73e-03	175	101	4	19851445
Pubmed	Network organization of the human autophagy system.	GBF1 MAP3K5 ARG1 COL18A1 WDR11 VARS1	1.77e-03	437	101	6	20562859
Pubmed	The DNA sequence of human chromosome 22.	NDUFA6 PEX26 SLC5A1 SELENOO SMC1B	1.86e-03	300	101	5	10591208
Pubmed	A germline-specific class of small RNAs binds mammalian Piwi proteins.	FAM83H SLC5A6 GID8 DOT1L VARS1 ANKS1A	2.04e-03	450	101	6	16751776
Pubmed	Loss of semaphorin-neuropilin-1 signaling causes dysmorphic vascularization reminiscent of alveolar capillary dysplasia.	SEMA3F SEMA3E	2.21e-03	24	101	2	23063659
Pubmed	Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool.	DCHS2 DCHS1	2.21e-03	24	101	2	26116661
Pubmed	An atlas of genetic influences on human blood metabolites.	ABCC1 SLC5A11 PAOX SLC5A6	2.33e-03	190	101	4	24816252
Pubmed	Tissue-specific activities of the Fat1 cadherin cooperate to control neuromuscular morphogenesis.	ETV4 SEMA3E	2.40e-03	25	101	2	29768404
Pubmed	Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development.	DCHS2 DCHS1	2.59e-03	26	101	2	21303848
Pubmed	Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube.	SEMA3F SEMA3E	2.80e-03	27	101	2	25843547
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	MPO DNHD1 SLC5A1 COL18A1 ARSL MEGF8 NAPRT P3H1 PKHD1	2.84e-03	1016	101	9	19056867
Interaction	LYPD2 interactions	GLB1L ARSB TMEM132A	9.45e-06	9	99	3	int:LYPD2
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	MIS18BP1 CHD7 MSANTD4	7.59e-04	53	61	3	532
GeneFamily	C2 domain containing\|Calpains	CAPN11 CAPN13	1.14e-03	15	61	2	975
GeneFamily	Cadherin related	DCHS2 DCHS1	1.47e-03	17	61	2	24
GeneFamily	Sulfatases	ARSB ARSL	1.65e-03	18	61	2	410
GeneFamily	Immunoglobulin like domain containing\|Semaphorins	SEMA3F SEMA3E	2.05e-03	20	61	2	736
GeneFamily	Selenoproteins	GPX1 SELENOO	3.20e-03	25	61	2	890
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FRAS1 HIF3A SHROOM4 AEBP2 PKHD1 SEMA3E	4.76e-06	190	101	6	8aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DDR1 CHD7 HIF3A SLC5A11 SHROOM4 KIAA1755	4.76e-06	190	101	6	07f21386ea6eb23416a537d2250e3042efe93fb0
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DDR1 CHD7 HIF3A SLC5A11 SHROOM4 KIAA1755	4.76e-06	190	101	6	ae97df1b06bcd46c05759b53c35dc8fea97f4ac1
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DDR1 CHD7 HIF3A SLC5A11 SHROOM4 KIAA1755	4.91e-06	191	101	6	2b056cbe2e82e056e1f798974999378460eb1d16
ToppCell	facs-Heart-Unknown-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HJV FRAS1 MIS18BP1 ARG1 HHIPL1	2.93e-05	157	101	5	8d30d8e6fae93afcada6bd68799439335cd65b69
ToppCell	facs-Heart-Unknown-3m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HJV FRAS1 MIS18BP1 ARG1 HHIPL1	2.93e-05	157	101	5	2ac4695d9e4ca8d4ba19c555e9a1d86ac8f398ab
ToppCell	facs-Heart-Unknown-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HJV FRAS1 MIS18BP1 ARG1 HHIPL1	2.93e-05	157	101	5	8a393eece90fb9a1b7c356736bdb36277261fbd3
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MIS18BP1 CASP4 PTPN22 CENPK OTOF	3.03e-05	158	101	5	91d265e95156f16459924d3e4dd11c180e164eee
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAM53C ARG1 PAOX SLC5A6 AEBP2	3.12e-05	159	101	5	f7bccfeffa737f151417bf52ea45111b0957bce9
ToppCell	droplet-Heart-nan-18m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MIS18BP1 NAP1L2 CENPK FAM83H OTOF	3.41e-05	162	101	5	7f425a3983325a5a3ea33f812b15aa010cc55de0
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MIS18BP1 USP20 FAM83H ARSB RINL	3.62e-05	164	101	5	ae09e5aabd1347b865474255e7411c04f63efb3b
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Lymphocytic-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO TMEM221 UNC13D PTPN22 CENPK	3.94e-05	167	101	5	41675d15919104c9e20cd97620fe636f3ff33fa9
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Lymphocytic\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO TMEM221 UNC13D PTPN22 CENPK	3.94e-05	167	101	5	3d5a6a4c7d037b1a6a8ec90034d88ef6d256e843
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ETV4 MATN4 HHIPL1 GRIN3B	5.04e-05	89	101	4	b66575739cb5b89234bbb8a3ea2f244e0bd19cff
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ETV4 MATN4 HHIPL1 GRIN3B	5.04e-05	89	101	4	26f01e8530b313dd5e95ea6c20fa362e34b9ed24
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC5A1 SLC5A11 ARSB PKHD1 KIAA1755	5.20e-05	177	101	5	2f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-1\|TCGA-Liver / Sample_Type by Project: Shred V9	FRAS1 ATP8A2 UNC13D TMEM132A PKHD1	5.34e-05	178	101	5	51c59dabf2d7aef1b1964f6f766d5ec07ef90f5a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC47A2 SLC5A1 SLC5A11 ARSB KIAA1755	5.48e-05	179	101	5	d1ef7e1cb00336118e387b47f4f8120f53584391
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DDR1 FRAS1 UNC13D PKHD1 SEMA3E	5.48e-05	179	101	5	04ce3673e46606f63d9c87bcba3a64c96817d812
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DDR1 FRAS1 UNC13D PKHD1 SEMA3E	5.78e-05	181	101	5	b45b11428d13950369347e051d4d517efb2bd4fd
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 ETV4 VWA7 TMEM132A KIAA1755	5.78e-05	181	101	5	7af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCell	10x5'v1-week_17-19-Lymphocytic_T-T_NK-CD8_T_cell\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SEMA3F FRAS1 PASK COL18A1 DCHS1	5.93e-05	182	101	5	98c26ad34e01c4b8997d26d5d28a9935491295fa
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ABCC1 UNC13D TFE3 CCNY MAP3K5	6.09e-05	183	101	5	310ad42b2b5d8ddd01d3a12db338f80ac1f5d08e
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ABCC1 UNC13D TFE3 CCNY MAP3K5	6.09e-05	183	101	5	fef51dcf180e6d4e136362c7e140ec5ef372e6d0
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DDR1 CHD7 SLC5A11 SHROOM4 KIAA1755	6.25e-05	184	101	5	a2191dd5546efd357b23e625beb3c5820476f243
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC5A1 SLC5A11 ARSB KIAA1755 D2HGDH	6.25e-05	184	101	5	9434731f651820b05335085582960f08fbf895de
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DDR1 CHD7 SLC5A11 SHROOM4 KIAA1755	6.41e-05	185	101	5	b5277190866d9eb5b85eceaa5ba116ea6e6f286b
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DDR1 FRAS1 UNC13D PKHD1 SEMA3E	6.41e-05	185	101	5	c82eab551f65ecebe6db908eda9f9eb3414693c7
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DDR1 FRAS1 UNC13D PKHD1 SEMA3E	6.57e-05	186	101	5	3aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC5A1 SLC5A11 ARSB KIAA1755 D2HGDH	6.57e-05	186	101	5	a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCell	P15-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DDR1 UNC13D MATN4 BCAR3 SEMA3E	6.57e-05	186	101	5	521e6e007bbae73e7328153aa170cf04ca3c1093
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CABP1 SLC47A2 SLC5A1 PKHD1 KIAA1755	6.57e-05	186	101	5	b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCell	COVID-19_Mild-Neu_4\|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients	MPO ABCC1 CENPK P3H1 D2HGDH	6.74e-05	187	101	5	714851e757c71c559ee6413a3f61d6c117c79ad2
ToppCell	AT1_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	DDR1 FRAS1 UNC13D SLC5A1 COL18A1	6.74e-05	187	101	5	f1dda349335e08dbfc8395d373924037f5ad2fd6
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DDR1 CHD7 SLC5A11 SHROOM4 KIAA1755	6.74e-05	187	101	5	97e520705491c8f52a32025311a9fa7b9176979a
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DDR1 FRAS1 UNC13D MAP3K5 PKHD1	6.74e-05	187	101	5	58d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHD7 HIF3A SLC5A11 SHROOM4 KIAA1755	6.91e-05	188	101	5	505b6b4277d7dea87aee27191d0acca67928b8e6
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHD7 HIF3A SLC5A11 SHROOM4 KIAA1755	7.09e-05	189	101	5	784ace2be87f2ecb19490f4974f63a559516e0eb
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHD7 HIF3A SLC5A11 SHROOM4 KIAA1755	7.09e-05	189	101	5	42ab4cc5fbf8580841f31889446fe4499df1a464
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHD7 HIF3A SLC5A11 SHROOM4 KIAA1755	7.09e-05	189	101	5	37ecbd73408d462b47d7e5611f203143e08a2689
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHD7 HIF3A SLC5A11 SHROOM4 KIAA1755	7.27e-05	190	101	5	2de8e4cfeee350a9a76af749d6ce58d948c129b8
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHD7 HIF3A SLC5A11 SHROOM4 KIAA1755	7.45e-05	191	101	5	f3158cedf67e3b90aa94ea1f61c72c33aaa2d5ba
ToppCell	P07-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FRAS1 UNC13D MATN4 BCAR3 SEMA3E	7.45e-05	191	101	5	0f360766490bef3495c42f6421b22a988cfc68fb
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHD7 HIF3A SLC5A11 SHROOM4 KIAA1755	7.45e-05	191	101	5	a90c8ab2077e52bbc998457c85a1b9867f9c8c93
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DCHS2 FRAS1 VWA7 OTOF PKHD1	7.82e-05	193	101	5	315840bc48899f3a36d57b19197509de19716e3d
ToppCell	18-Distal-Mesenchymal-Cartilage\|Distal / Age, Tissue, Lineage and Cell class	CHRDL2 MATN4 DACT1 KIAA1755 SMC1B	7.82e-05	193	101	5	52f3d1bb8d8ca91ba12439d46392f377928ff8f8
ToppCell	background-Cholangiocytes\|background / Sample and Cell Type and Tumor Cluster (all cells)	DDR1 FRAS1 ETV4 SLC5A1 PKHD1	7.82e-05	193	101	5	9152241073dbe02ac2c11d86bec9b5b529196f6e
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FRAS1 CHD7 COL18A1 ZDHHC22 BCAR3	8.62e-05	197	101	5	bb35a2b7320fda92e9cd42f536b7bd54e3a73a32
ToppCell	Influenza-Influenza_Severe-Others-RBC\|Influenza_Severe / Disease, condition lineage and cell class	USP20 ARG1 COL18A1 TRAK2 EPB41	9.04e-05	199	101	5	da0fec0a492bc3827d9066d2590bcd466cd45564
ToppCell	Macroglial\|World / cells hierarchy compared to all cells using T-Statistic	CHD7 HIF3A SLC5A11 SHROOM4 KIAA1755	9.25e-05	200	101	5	e6935ad49216d2500c15c05cbc2b89402c65e838
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	MIS18BP1 NDST4 CHD7 HIF3A NDUFA6	9.25e-05	200	101	5	c792d1dbbe27ebd60f4770834f30882c1a625be5
Disease	CHARGE Syndrome	CHD7 SEMA3E	1.07e-05	2	97	2	C0265354
Disease	Familial CHARGE Syndrome	CHD7 SEMA3E	1.07e-05	2	97	2	C2936502
Disease	Idiopathic hypogonadotropic hypogonadism	CHD7 WDR11 SEMA3E	2.71e-05	18	97	3	C0342384
Disease	Uveomeningoencephalitic Syndrome	PTPN22 CYP2R1	6.39e-05	4	97	2	C0042170
Disease	CHARGE syndrome (implicated_via_orthology)	CHD7 SEMA3E	2.22e-04	7	97	2	DOID:0050834 (implicated_via_orthology)
Disease	N4-acetylcytidine measurement	SLC47A2 CAPN11	2.22e-04	7	97	2	EFO_0800628
Disease	HYPOGONADOTROPIC HYPOGONADISM 7 WITH OR WITHOUT ANOSMIA	WDR11 SEMA3E	5.77e-04	11	97	2	146110
Disease	Hypogonadotropic hypogonadism 7 with or without anosmia	WDR11 SEMA3E	5.77e-04	11	97	2	cv:C0342384
Disease	unipolar depression	NRDC CATSPERD CASP4 UNC13D CHD7 BTN2A1 MAP3K5 ARSB PKHD1 DCHS1 BCAR3 SEMA3E	5.96e-04	1206	97	12	EFO_0003761
Disease	Amelogenesis Imperfecta	PEX26 FAM83H	6.91e-04	12	97	2	C0002452
Disease	diabetic angiopathy (is_marker_for)	GPX1 GP1BA	6.91e-04	12	97	2	DOID:11713 (is_marker_for)
Disease	Amino Acid Metabolism, Inherited Disorders	ARG1 D2HGDH	8.15e-04	13	97	2	C0750905
Disease	Amino Acid Metabolism, Inborn Errors	ARG1 D2HGDH	8.15e-04	13	97	2	C0002514
Disease	Osteopenia	CYP2R1 SLC5A6	1.09e-03	15	97	2	C0029453
Disease	chronic obstructive pulmonary disease	DCHS2 FRAS1 VWA7 ATF6B BTN2A1 AEBP2 DOT1L VARS1	1.96e-03	688	97	8	EFO_0000341
Disease	cardiovascular system disease (is_implicated_in)	MPO GPX1	2.16e-03	21	97	2	DOID:1287 (is_implicated_in)
Disease	Inguinal hernia	DDR1 VWA7 ATF6B BTN2A1 VARS1	2.62e-03	287	97	5	HP_0000023
Disease	testosterone measurement	DDR1 DCHS2 NRDC UNC13D CHD7 KCTD11 SHROOM4 DACT1 WDR11 HHIPL1 VARS1	3.12e-03	1275	97	11	EFO_0004908

Protein segments in the cluster

Peptide	Gene	Start	Entry
SALIDRPAPHFERTA	EPB41	521	P11171
LPRPHDFFDAQTLDA	AEBP2	391	Q6ZN18
PLLFDLSRDPSETHI	ARSL	511	P51690
EILTPLRDTAFPAFD	CATSPERD	351	Q86XM0
ETFTFRDPHLLDPTV	BCAR3	101	O75815
FDHLPPRNGADFDIT	CASP4	146	P49662
PPFSQLHRFLAEDAL	DDR1	896	Q08345
FAFLREALPAPSDDA	GPX1	126	P07203
LHPFFAGLTPEERSF	CLK3	616	P49761
GPPHFILDDISRFDI	CAPN13	71	Q6MZZ7
DSLHDPAAPSRAERF	ANKS1A	886	Q92625
EFNPSDHPRASTIFL	CCNY	56	Q8ND76
FDLHVSPEDGTLVPF	DNHD1	2331	Q96M86
SLFTFRPALEEPSAD	DOT1L	1271	Q8TEK3
IIPSTFEPHRDADFL	CAPN11	521	Q9UMQ6
HEAFIPSPDGDRDIF	DIS3L2	81	Q8IYB7
AAASEADPFLHRLRP	CABP1	196	Q9NZU7
SLLHFLEPSRFPSET	CHD7	1146	Q9P2D1
GHFPELAREPSSDDF	ATP8A2	451	Q9NTI2
PIHLSFDVDGLDPSF	ARG1	226	P05089
PPLDSEDLFQDLSHF	ETV4	46	P43268
LSPALPAEHLEDRLF	RBM15B	146	Q8NDT2
LSDPGEPLSFTLEFH	NAP1L2	276	Q9ULW6
AFLPDLEKLHLFPSD	HJV	386	Q6ZVN8
DSDLYFVSHLPREPS	ITPRIP	356	Q8IWB1
PLPERTLESFFLADE	PTPN22	696	Q9Y2R2
LASHPSREKPFEDFL	P3H1	286	Q32P28
PEHDFSSFLEVRPDG	ANKRD53	416	Q8N9V6
EHAPAFARDPLALAL	DCHS1	1431	Q96JQ0
FAFIDRHPRLDEPLA	PASK	1091	Q96RG2
DVPFEAHFASELPDF	FRAS1	3776	Q86XX4
SPPLDEHVFLVESFD	MATN4	186	O95460
LPKDDHDDFFSTTPL	MIS18BP1	981	Q6P0N0
LPHFRRPFFEEAAAE	MAGEE1	706	Q9HCI5
PEHASDYLRPLLSFA	ENTPD7	141	Q9NQZ7
AAHLYDAEDPFTPLR	HHIPL1	91	Q96JK4
LHTDSSLPFSFPDEL	MTMR14	571	Q8NCE2
PDPAREHLLATTFFR	KIAA1755	1146	Q5JYT7
LFGDPDEFPLAHLLE	PDCD7	411	Q8N8D1
HDLDFTPEPAARASF	MPO	261	P05164
VVRFDPASPSSLHFL	PEX26	266	Q7Z412
DFSLLFHIRPATEGP	COL18A1	506	P39060
FFHETEAPRPKDFLS	NDUFA6	106	P56556
GFRFHVELAAPSPEL	MEGF8	1691	Q7Z7M0
FHSEEAPRRAASLVP	NDST4	671	Q9H3R1
LDASIHPFRLPFSSK	PRNT	21	Q86SH4
GEIFSAHELFPSRLP	CHRDL2	121	Q6WN34
FRLPVAHDPDAGLFS	DCHS2	186	Q6V1P9
EDLDLFPASPTREAH	FBF1	351	Q8TES7
LSTAFPVEERPALDF	DACT1	526	Q9NYF0
TFEISIPFDEAPHLD	CCDC106	16	Q9BWC9
DPEVFHPERFLDSSG	CYP2R1	416	Q6VVX0
GEFLEDHFPLPDRSV	CENPK	181	Q9BS16
PEIHLRTSDPDFLAA	GLB1L	141	Q6UWU2
AFDSPEESPFGDLLH	GID8	151	Q9NWU2
VLDPDTAHPDLFLSE	BTN2A1	331	Q7KYR7
HLESSRNDPFLHPDF	GP1BA	511	P07359
ASRPPHLVFLLADDL	ARSB	41	P15848
PLDEERDPLLHSFGH	GBF1	31	Q92538
PSFLDPDRHFLSAFR	FAM83H	341	Q6ZRV2
RFSISLPLPDHADIS	FAM53C	21	Q9NYF3
AEAFSPSLLAALEPH	D2HGDH	446	Q8N465
RFLADEPQHSIPDIF	OTOF	836	Q9HC10
FLREHLDTFFDPPLP	PAOX	291	Q6QHF9
FSDRSPLFSETIHDP	ABCC1	191	P33527
EHGFRLDSVFPDPED	KCTD11	206	Q693B1
VPELRPHFSLASESD	MAP3K5	1171	Q99683
TLLEHPFVFARDPDE	GRIN3B	421	O60391
HPFLSRSLPIVFDEF	VARS1	566	P26640
RSVSAEEPLHLFFAP	RFPL1	271	O75677
DLHPDVFATAPRLDI	MRPL4	81	Q9BYD3
PSFIHAELIPDSAER	SEMA3F	256	Q13275
LLSFATRFHRLDEPP	POMT2	66	Q9UKY4
DFFRTPEEAHALSAP	SLC47A2	551	Q86VL8
LPAALELLDAPEHFR	TMEM132A	46	Q24JP5
ISGFELDPDPFVRHT	SLC5A6	241	Q9Y289
FLHPPSLSEAALAAD	HIF3A	391	Q9Y2N7
PPAREAEAEAALFFS	SELENOO	111	Q9BVL4
ESFALHSSDFLPPIR	SHROOM4	1206	Q9ULL8
DAFHIFRDPLTSDLP	SLC5A11	256	Q8WWX8
LSRPFAGFEDFLPSH	SBNO2	151	Q9Y2G9
FPFPHAAILEDLDGS	PKHD1	2516	P08F94
ELPDFPHIDEFFTLN	MSANTD4	176	Q8NCY6
ADPTRFFTDNLLSPE	ATF6B	11	Q99941
PDLPHLLAFLSASRD	RINL	116	Q6ZS11
PFEPRVHLSENFLAS	TRAK2	791	O60296
EDPAAARLFSPALLH	ZDHHC22	36	Q8N966
PSDALLDLHFPSDHL	TFE3	496	P19532
HSFRPAPFFVLDEVD	SMC1B	1141	Q8NDV3
HAPDLQDFFVLPELR	SNX21	231	Q969T3
TDHGFETDPDPFLLD	ZNF395	251	Q9H8N7
SFADPDDLPGLAHFL	NRDC	221	O43847
PDTDPAFFEHLRALD	NAPRT	86	Q6XQN6
SHVSFPLEGLDLRPF	USP20	601	Q9Y2K6
RGLHELSPPSFEDDL	TMEM221	181	A6NGB7
LEDPLFHLESPRSER	SEMA3E	151	O15041
FETEHKLDPVFDSPR	SUN1	36	O94901
FDPFDPSHLTLLTSE	WDR11	166	Q9BZH6
DSFHIFRDPLTGDLP	SLC5A1	261	P13866
FLPTSRNDPDLHFDA	VWA7	116	Q9Y334
SDPFVQLTLEPRHEF	UNC13D	946	Q70J99