Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR52B4 OR4S1 TAS2R14 GPR65 CCR9 FSHR DNER RXFP3 HTR3B TAS2R60 OR10J1 S1PR1 FFAR4 IFNAR2	1.96e-05	1353	57	14	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR52B4 OR4S1 TAS2R14 GPR65 CCR9 FSHR RXFP3 TAS2R60 OR10J1 S1PR1 FFAR4	3.43e-05	884	57	11	GO:0004930
GeneOntologyMolecularFunction	taste receptor activity	TAS2R14 TAS2R60 FFAR4	1.13e-04	33	57	3	GO:0008527
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1F CACNA1S	7.13e-04	14	57	2	GO:0008331
GeneOntologyMolecularFunction	transporter activity	KCNE2 CACNA1F CACNA1S ATP2C1 SLCO1C1 CLCN5 SCN5A STARD3 HTR3B RFT1 SLC33A1	9.16e-04	1289	57	11	GO:0005215
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	KCNE2 CACNA1F CACNA1S CLCN5	1.81e-03	182	57	4	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	KCNE2 CACNA1F CACNA1S CLCN5	1.88e-03	184	57	4	GO:0022832
GeneOntologyMolecularFunction	monoatomic ion channel activity	KCNE2 CACNA1F CACNA1S CLCN5 SCN5A HTR3B	1.92e-03	459	57	6	GO:0005216
GeneOntologyMolecularFunction	gated channel activity	KCNE2 CACNA1F CACNA1S CLCN5 HTR3B	2.61e-03	334	57	5	GO:0022836
GeneOntologyMolecularFunction	bitter taste receptor activity	TAS2R14 TAS2R60	2.68e-03	27	57	2	GO:0033038
GeneOntologyMolecularFunction	monoatomic cation channel activity	KCNE2 CACNA1F CACNA1S SCN5A HTR3B	2.93e-03	343	57	5	GO:0005261
GeneOntologyBiologicalProcess	phospholipase C-activating G protein-coupled receptor signaling pathway	GPR65 FSHR RXFP3 S1PR1 FFAR4	3.31e-05	133	57	5	GO:0007200
GeneOntologyBiologicalProcess	regulation of ventricular cardiac muscle cell membrane repolarization	KCNE2 AKAP9 SCN5A	4.41e-05	25	57	3	GO:0060307
GeneOntologyBiologicalProcess	ventricular cardiac muscle cell membrane repolarization	KCNE2 AKAP9 SCN5A	7.70e-05	30	57	3	GO:0099625
GeneOntologyBiologicalProcess	regulation of cardiac muscle cell membrane repolarization	KCNE2 AKAP9 SCN5A	7.70e-05	30	57	3	GO:0099623
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	CACNA1F OR52B4 OR4S1 TAS2R14 PJVK TAS2R60 OR10J1 FFAR4	1.87e-04	582	57	8	GO:0050906
GeneOntologyBiologicalProcess	cardiac muscle cell membrane repolarization	KCNE2 AKAP9 SCN5A	1.98e-04	41	57	3	GO:0099622
GeneOntologyBiologicalProcess	regulation of heart rate by cardiac conduction	KCNE2 AKAP9 SCN5A	1.98e-04	41	57	3	GO:0086091
GeneOntologyBiologicalProcess	regulation of membrane repolarization	KCNE2 AKAP9 SCN5A	1.98e-04	41	57	3	GO:0060306
GeneOntologyBiologicalProcess	striated muscle contraction	KCNE2 CACNA1S AKAP9 SCN5A PDE5A	3.30e-04	217	57	5	GO:0006941
GeneOntologyBiologicalProcess	skeletal muscle fiber development	CACNA1S DNER XK	3.37e-04	49	57	3	GO:0048741
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of taste	TAS2R14 TAS2R60 FFAR4	3.58e-04	50	57	3	GO:0050912
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR52B4 OR4S1 TAS2R14 GPR65 CCR9 FSHR PDE5A RXFP3 TAS2R60 OR10J1 S1PR1 FFAR4	3.58e-04	1395	57	12	GO:0007186
GeneOntologyCellularComponent	cation channel complex	KCNE2 CACNA1F CACNA1S AKAP9 SCN5A HTR3B	4.26e-05	235	57	6	GO:0034703
GeneOntologyCellularComponent	monoatomic ion channel complex	CYBB KCNE2 CACNA1F CACNA1S AKAP9 SCN5A HTR3B	7.26e-05	378	57	7	GO:0034702
GeneOntologyCellularComponent	transmembrane transporter complex	CYBB KCNE2 CACNA1F CACNA1S AKAP9 SCN5A HTR3B	5.28e-04	523	57	7	GO:1902495
GeneOntologyCellularComponent	transporter complex	CYBB KCNE2 CACNA1F CACNA1S AKAP9 SCN5A HTR3B	7.11e-04	550	57	7	GO:1990351
HumanPheno	Abnormal cardiac exercise stress test	KCNE2 AKAP9 SCN5A	4.82e-05	19	20	3	HP:0500018
HumanPheno	Prolonged QT interval	KCNE2 CACNA1S AKAP9 SCN5A	4.82e-05	54	20	4	HP:0001657
HumanPheno	Supraventricular tachycardia	KCNE2 CACNA1S AKAP9 SCN5A XK	7.79e-05	120	20	5	HP:0004755
HumanPheno	Ventricular fibrillation	KCNE2 CACNA1S AKAP9 SCN5A	8.87e-05	63	20	4	HP:0001663
HumanPheno	Abnormal QT interval	KCNE2 CACNA1S AKAP9 SCN5A	9.44e-05	64	20	4	HP:0031547
HumanPheno	Torsade de pointes	KCNE2 AKAP9 SCN5A	1.13e-04	25	20	3	HP:0001664
HumanPheno	Supraventricular arrhythmia	KCNE2 CACNA1S AKAP9 SCN5A XK	1.32e-04	134	20	5	HP:0005115
HumanPheno	Prolonged QTc interval	KCNE2 AKAP9 SCN5A	1.77e-04	29	20	3	HP:0005184
HumanPheno	Sinus bradycardia	KCNE2 AKAP9 SCN5A	1.96e-04	30	20	3	HP:0001688
HumanPheno	Hypokalemia	KCNE2 CACNA1S AKAP9 SCN5A	2.15e-04	79	20	4	HP:0002900
HumanPheno	Abnormal blood monovalent inorganic cation concentration	KCNE2 CACNA1S AKAP9 DSG1 SCN5A	2.54e-04	154	20	5	HP:0010930
HumanPheno	Abnormal T-wave	KCNE2 AKAP9 SCN5A	3.69e-04	37	20	3	HP:0005135
HumanPheno	Premature atrial contractions	KCNE2 SCN5A	4.04e-04	8	20	2	HP:0006699
HumanPheno	Permanent atrial fibrillation	KCNE2 SCN5A	5.19e-04	9	20	2	HP:0004754
HumanPheno	Abnormal blood cation concentration	KCNE2 CACNA1S AKAP9 CLCN5 DSG1 SCN5A SLC33A1	5.59e-04	401	20	7	HP:0010929
HumanPheno	Acantholysis	ATP2C1 DSG1	6.47e-04	10	20	2	HP:0100792
HumanPheno	Tachycardia	KCNE2 CACNA1S AKAP9 SCN5A XK	6.56e-04	189	20	5	HP:0001649
Domain	VDCC_L_a1su	CACNA1F CACNA1S	5.28e-05	4	56	2	IPR005446
Domain	GPCR_Rhodpsn_7TM	OR52B4 OR4S1 GPR65 CCR9 FSHR RXFP3 OR10J1 S1PR1 FFAR4	1.56e-04	670	56	9	IPR017452
Domain	7tm_1	OR52B4 OR4S1 GPR65 CCR9 FSHR RXFP3 OR10J1 S1PR1 FFAR4	1.69e-04	677	56	9	PF00001
Domain	GPHH_dom	CACNA1F CACNA1S	1.84e-04	7	56	2	IPR031649
Domain	VDCC_a1su_IQ	CACNA1F CACNA1S	1.84e-04	7	56	2	IPR014873
Domain	Ca_chan_IQ	CACNA1F CACNA1S	1.84e-04	7	56	2	SM01062
Domain	Ca_chan_IQ	CACNA1F CACNA1S	1.84e-04	7	56	2	PF08763
Domain	GPHH	CACNA1F CACNA1S	1.84e-04	7	56	2	PF16905
Domain	G_PROTEIN_RECEP_F1_1	OR52B4 OR4S1 GPR65 CCR9 FSHR RXFP3 OR10J1 S1PR1 FFAR4	1.84e-04	685	56	9	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR52B4 OR4S1 GPR65 CCR9 FSHR RXFP3 OR10J1 S1PR1 FFAR4	1.97e-04	691	56	9	PS50262
Domain	GPCR_Rhodpsn	OR52B4 OR4S1 GPR65 CCR9 FSHR RXFP3 OR10J1 S1PR1 FFAR4	1.99e-04	692	56	9	IPR000276
Domain	VDCCAlpha1	CACNA1F CACNA1S	3.91e-04	10	56	2	IPR002077
Domain	Channel_four-helix_dom	CACNA1F CACNA1S SCN5A	6.66e-04	57	56	3	IPR027359
Domain	-	CACNA1F CACNA1S SCN5A	6.66e-04	57	56	3	1.20.120.350
Domain	TAS2R	TAS2R14 TAS2R60	2.74e-03	26	56	2	PF05296
Domain	T2R	TAS2R14 TAS2R60	2.74e-03	26	56	2	IPR007960
Domain	ARM-type_fold	RIF1 URB1 NOM1 CIP2A USP35	3.42e-03	339	56	5	IPR016024
Domain	Ion_trans_dom	CACNA1F CACNA1S SCN5A	4.85e-03	114	56	3	IPR005821
Domain	Ion_trans	CACNA1F CACNA1S SCN5A	4.85e-03	114	56	3	PF00520
Pathway	REACTOME_GPCR_LIGAND_BINDING	TAS2R14 GPR65 CCR9 FSHR XK RXFP3 TAS2R60 S1PR1 FFAR4	2.21e-05	463	48	9	M507
Pathway	WP_GPCRS_NONODORANT	TAS2R14 GPR65 CCR9 FSHR RXFP3 S1PR1 FFAR4	2.99e-05	266	48	7	MM15843
Pathway	REACTOME_GPCR_LIGAND_BINDING	TAS2R14 GPR65 CCR9 FSHR XK RXFP3 TAS2R60 S1PR1	9.08e-05	430	48	8	MM15160
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	GPR65 CCR9 FSHR XK RXFP3 S1PR1 FFAR4	1.17e-04	330	48	7	M18334
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1F CACNA1S	1.69e-04	6	48	2	M47762
Pathway	REACTOME_SIGNALING_BY_GPCR	TAS2R14 GPR65 CCR9 FSHR XK RXFP3 TAS2R60 S1PR1 FFAR4	2.84e-04	646	48	9	MM14962
Pathway	REACTOME_PHASE_3_RAPID_REPOLARISATION	KCNE2 AKAP9	3.14e-04	8	48	2	MM15195
Pathway	REACTOME_PHASE_3_RAPID_REPOLARISATION	KCNE2 AKAP9	4.03e-04	9	48	2	M27453
Pubmed	High-resolution comparative mapping of the proximal region of the mouse X chromosome.	CYBB CLCN5 XK	1.45e-07	7	57	3	8530041
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	KCNE2 CACNA1F CACNA1S CLCN5 SCN5A	3.36e-06	139	57	5	16985003
Pubmed	Long QT Syndrome Overview	KCNE2 AKAP9 SCN5A	3.97e-06	19	57	3	20301308
Pubmed	Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.	CACNA1F CACNA1S	1.58e-05	4	57	2	20937870
Pubmed	Torsades de pointes complicating atrioventricular block: evidence for a genetic predisposition.	KCNE2 SCN5A	1.58e-05	4	57	2	17275752
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	NAA35 URB1 UBC ATP2C1 CIP2A SREBF2 RFT1 VPS51 SLC33A1	2.12e-05	942	57	9	31073040
Pubmed	A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation.	CACNA1F CLCN5 XK	2.41e-05	34	57	3	10857745
Pubmed	Cardiac ion channel gene mutations in Greek long QT syndrome patients.	KCNE2 SCN5A	2.63e-05	5	57	2	21063070
Pubmed	Common variants in cardiac ion channel genes are associated with sudden cardiac death.	KCNE2 SCN5A	2.63e-05	5	57	2	20400777
Pubmed	Relationship between genetic variants in myocardial sodium and potassium channel genes and QT interval duration in diabetics: the Diabetes Heart Study.	KCNE2 SCN5A	2.63e-05	5	57	2	19149796
Pubmed	Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients.	KCNE2 SCN5A	2.63e-05	5	57	2	14760488
Pubmed	Molecular genetic analysis of long QT syndrome in Norway indicating a high prevalence of heterozygous mutation carriers.	KCNE2 SCN5A	2.63e-05	5	57	2	18752142
Pubmed	Genetic testing in the long QT syndrome: development and validation of an efficient approach to genotyping in clinical practice.	KCNE2 SCN5A	2.63e-05	5	57	2	16414944
Pubmed	Long QT and Brugada syndrome gene mutations in New Zealand.	KCNE2 SCN5A	2.63e-05	5	57	2	17905336
Pubmed	Prevalence and spectrum of large deletions or duplications in the major long QT syndrome-susceptibility genes and implications for long QT syndrome genetic testing.	KCNE2 SCN5A	2.63e-05	5	57	2	20920651
Pubmed	Do LQTS gene single nucleotide polymorphisms alter QTc intervals at rest and during exercise stress testing?	KCNE2 SCN5A	2.63e-05	5	57	2	23714088
Pubmed	Compound mutations: a common cause of severe long-QT syndrome.	KCNE2 SCN5A	2.63e-05	5	57	2	15051636
Pubmed	Correlation of genetic etiology with response to beta-adrenergic blockade among symptomatic patients with familial long-QT syndrome.	KCNE2 SCN5A	2.63e-05	5	57	2	11289718
Pubmed	Allelic dropout in long QT syndrome genetic testing: a possible mechanism underlying false-negative results.	KCNE2 SCN5A	2.63e-05	5	57	2	16818214
Pubmed	Torsades de pointes during complete atrioventricular block: Genetic factors and electrocardiogram correlates.	KCNE2 SCN5A	2.63e-05	5	57	2	20386770
Pubmed	The electrocardiographic abnormalities in highly trained athletes compared to the genetic study related to causes of unexpected sudden cardiac death.	KCNE2 SCN5A	2.63e-05	5	57	2	20108749
Pubmed	Confirmation of associations between ion channel gene SNPs and QTc interval duration in healthy subjects.	KCNE2 SCN5A	2.63e-05	5	57	2	17534376
Pubmed	Four potassium channel mutations account for 73% of the genetic spectrum underlying long-QT syndrome (LQTS) and provide evidence for a strong founder effect in Finland.	KCNE2 SCN5A	2.63e-05	5	57	2	15176425
Pubmed	Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing.	KCNE2 SCN5A	2.63e-05	5	57	2	15840476
Pubmed	Spectrum and prevalence of mutations from the first 2,500 consecutive unrelated patients referred for the FAMILION long QT syndrome genetic test.	KCNE2 SCN5A	2.63e-05	5	57	2	19716085
Pubmed	Contribution of long-QT syndrome genetic variants in sudden infant death syndrome.	KCNE2 SCN5A	2.63e-05	5	57	2	19322600
Pubmed	The mouse X-linked developmental mutant, tattered, lies between DXMit55 and Xkh and is associated with hyperkeratinization.	CYBB XK	3.94e-05	6	57	2	8921395
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1F CACNA1S	5.51e-05	7	57	2	12900400
Pubmed	Prevalence of long-QT syndrome gene variants in sudden infant death syndrome.	KCNE2 SCN5A	5.51e-05	7	57	2	17210839
Pubmed	GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment.	CCR9 S1PR1	7.34e-05	8	57	2	25348153
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1F CACNA1S	7.34e-05	8	57	2	28330839
Pubmed	Poor replication of candidate genes for major depressive disorder using genome-wide association data.	ACSL4 PDE5A HTR3B	8.22e-05	51	57	3	20351714
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1F CACNA1S	9.43e-05	9	57	2	16382099
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	RIF1 UBC USP35 VPS51	1.02e-04	147	57	4	29576527
Pubmed	USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1.	UBC DSG1	1.44e-04	11	57	2	19015242
Pubmed	Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN).	DNAH12 DSG1 CIP2A	1.70e-04	65	57	3	32120844
Pubmed	A high-density association screen of 155 ion transport genes for involvement with common migraine.	KCNE2 SCN5A	1.72e-04	12	57	2	18676988
Pubmed	A neurogenomics approach to gene expression analysis in the developing brain.	CACNA1S SUSD4 SLCO1C1 SLC33A1	1.78e-04	170	57	4	15582152
Pubmed	Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.	CCR9 RXFP3 S1PR1	2.59e-04	75	57	3	2834384
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1F CACNA1S	2.73e-04	15	57	2	20188150
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1F CACNA1S	2.73e-04	15	57	2	24453333
Pubmed	Ontogeny and Trophic Factor Sensitivity of Gastrointestinal Projecting Vagal Sensory Cell Types.	GPR65 HTR3B	4.43e-04	19	57	2	36973009
Pubmed	Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner.	RIF1 ATP2C1 DNAH12 DSG1	4.90e-04	222	57	4	35941108
Pubmed	Congenital heart defect causing mutation in Nkx2.5 displays in vivo functional deficit.	CACNA1S SCN5A	5.43e-04	21	57	2	28302382
Pubmed	Evolutionary relationships of the Tas2r receptor gene families in mouse and human.	TAS2R14 TAS2R60	5.97e-04	22	57	2	12734386
Pubmed	The molecular receptive ranges of human TAS2R bitter taste receptors.	TAS2R14 TAS2R60	6.53e-04	23	57	2	20022913
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	ACSL4 VIPAS39 AKAP9 CPSF6 NOM1 CIP2A CCDC138 SLC33A1 WDR43	6.86e-04	1496	57	9	32877691
Pubmed	Brugada Syndrome	KCNE2 SCN5A	7.12e-04	24	57	2	20301690
Pubmed	Receptors for bitter and sweet taste.	TAS2R14 TAS2R60	7.73e-04	25	57	2	12139982
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	NAA35 VIPAS39 CCDC138 VPS51	7.75e-04	251	57	4	29778605
Pubmed	Molecular mechanisms of bitter and sweet taste transduction.	TAS2R14 TAS2R60	8.36e-04	26	57	2	11696554
Pubmed	Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.	TAS2R14 TAS2R60	9.02e-04	27	57	2	12581520
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	UBC ATP2C1 SREBF2 STARD3 RFT1 SLC33A1 GPR107	9.05e-04	952	57	7	38569033
Pubmed	Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.	TAS2R14 TAS2R60	9.71e-04	28	57	2	15744053
Pubmed	Adaptive diversification of bitter taste receptor genes in Mammalian evolution.	TAS2R14 TAS2R60	1.11e-03	30	57	2	12679530
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	CLCN5 CIP2A DNER STARD3 VPS51 SLC33A1	1.13e-03	719	57	6	35337019
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	ACSL4 VIPAS39 SREBF2 STARD3 SLC33A1	1.41e-03	504	57	5	34432599
Pubmed	Evolution of bitter taste receptors in humans and apes.	TAS2R14 TAS2R60	1.43e-03	34	57	2	15496549
Interaction	GPR182 interactions	ACSL4 RIF1 URB1 ATP2C1 NOM1 CIP2A CCDC138 SREBF2 RFT1 VPS51 SLC33A1 GPR107	1.75e-09	455	53	12	int:GPR182
Interaction	TMEM9B interactions	RIF1 ATP2C1 CLCN5 SREBF2 STARD3	1.08e-05	111	53	5	int:TMEM9B
Drug	Verapamil	CACNA1F CACNA1S SCN5A	7.72e-06	16	56	3	DB00661
Drug	dofetilide	KCNE2 AKAP9 SCN5A SLC33A1	1.75e-05	63	56	4	CID000071329
Drug	3-(1H-pyrrole-2-carboxylate	MAG KCNE2 CACNA1S ATP2C1 SCN5A VPS51	2.28e-05	233	56	6	CID000005114
Drug	nicorandil	KCNE2 MGAM AKAP9 SCN5A	2.82e-05	71	56	4	CID000047528
Drug	clofilium	KCNE2 AKAP9 SCN5A SLC33A1	3.32e-05	74	56	4	CID000002798
Drug	HF-2	MGAM DSG1	3.55e-05	4	56	2	CID000015602
Drug	TAIC	MAG DNER	3.55e-05	4	56	2	CID000013931
Drug	N-cyclopentyl-N-cyclobutylformamide	CACNA1F CACNA1S ATP2C1 ACER3	4.30e-05	79	56	4	CID005287890
Disease	Congenital long QT syndrome	KCNE2 AKAP9 SCN5A	1.00e-06	11	55	3	cv:C1141890
Disease	Long QT syndrome	KCNE2 AKAP9 SCN5A	1.33e-06	12	55	3	cv:C0023976
Disease	Romano-Ward Syndrome	KCNE2 AKAP9 SCN5A	3.37e-06	16	55	3	C0035828
Disease	Timothy syndrome (implicated_via_orthology)	CACNA1F CACNA1S	2.04e-05	4	55	2	DOID:0060173 (implicated_via_orthology)
Disease	long QT syndrome (is_implicated_in)	KCNE2 SCN5A	7.12e-05	7	55	2	DOID:2843 (is_implicated_in)
Disease	Long QT Syndrome	KCNE2 SCN5A	1.86e-04	11	55	2	C0023976
Disease	familial atrial fibrillation (is_implicated_in)	KCNE2 SCN5A	3.06e-04	14	55	2	DOID:0050650 (is_implicated_in)
Disease	COVID-19, osteoarthritis	CCR9 IFNAR2	6.34e-04	20	55	2	MONDO_0005178, MONDO_0100096
Disease	ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)	KCNE2 SCN5A	7.69e-04	22	55	2	C1843687
Disease	progression free survival, ovarian serous carcinoma	MGAM PTCHD4	7.69e-04	22	55	2	EFO_0004920, EFO_1001516
Disease	Brugada Syndrome (disorder)	AKAP9 SCN5A	9.17e-04	24	55	2	C1142166
Disease	sensory perception of bitter taste	MGAM TAS2R14	1.08e-03	26	55	2	GO_0050913

Protein segments in the cluster

Peptide	Gene	Start	Entry
TVFLITTTLVALLKK	SLC33A1	266	O00400
LITSVELLESKLKTA	ACSL4	201	O60488
VLFSLIVTTVYLKVK	ACER3	126	Q9NUN7
LLKILLEVVKTTAAV	AKAP9	1731	Q99996
AFLVLSLAKSIVLVK	HTR3B	311	O95264
SKLTLKSLEVELKTV	ANKRD62	526	A6NC57
KTIKTLDNRILVITS	DNAJA4	276	Q8WW22
LTKNLILKILVSSII	ATP2C1	771	P98194
LKVIAESLSVILKSV	RFT1	151	Q96AA3
LKKQSVSVTLLILDI	GPR107	111	Q5VW38
TLFALVRTSLKIKTE	CACNA1F	1526	O60840
ILTIFKEKQILSTVI	MAG	356	P20916
LKKSAFVVLILLITA	GPR155	271	Q7Z3F1
LKKFTTLEIVLSVLL	MGAM	6	O43451
LVIVISYSKILQITK	FFAR4	221	Q5NUL3
TILTNALIKKICVTV	OR52B4	136	Q8NGK2
LLVIITINARKTLKS	OR4S1	41	Q8NGB4
SLEVILKKIAATIIS	PDE5A	346	O76074
IVSKILKILITFRIS	DNAH12	1736	Q6ZR08
SFIIVAILVSTVKSK	KCNE2	61	Q9Y6J6
FLIAVKRKTTETLII	MS4A5	101	Q9H3V2
KLKASAISVTVLNVI	DSG1	366	Q02413
FLIALVLTSTIVTLK	IFNAR2	251	P48551
LRFLSTLIVLKTVTQ	CCDC138	491	Q96M89
ETLVTAISLIKQSKV	CPSF6	446	Q16630
TLFALVRTALKIKTE	CACNA1S	1466	Q13698
ESTKLKSAVLTLKVI	CCR9	206	P51686
KALKVTITVLTVFVL	CCR9	251	P51686
LALTLILKIVITIFT	CLCN5	501	P51795
TSKVILLELSKSIRV	C1GALT1C1L	56	P0DN25
VITLCLILIITSSTK	CYBB	181	P04839
IIVLVILTTSQYKLT	FSHR	381	P23945
KSIVALRLTLVVKVS	DNER	291	Q8NFT8
KENSIKLTSVVFILI	S1PR1	41	P21453
SLALLKTVIIVLSVF	S1PR1	251	P21453
ISYVLIISTILKIAS	OR10J1	226	P30954
LSKVTKSVTIVVLSF	RXFP3	321	Q9NSD7
VKKVVLVLLLVTSVF	TAS2R14	126	Q9NYV8
SVTDKKAIILVTILL	TAS2R60	11	P59551
VLTLLLKSLESIVKS	RIF1	526	Q5UIP0
LVLSEVKTLSVKGIT	RESF1	766	Q9HCM1
KVLVSLVLILTTATL	PTCHD4	236	Q6ZW05
ALKTISVISGLKTIV	SCN5A	226	Q14524
KTKSLSLSILKVVEF	NOM1	756	Q5C9Z4
LSLISVILKRALKTV	URB1	456	O60287
VTTLVSSAFLIVKVI	STARD3	126	Q14849
IAKILTTVKCTTLIE	CIP2A	436	Q8TCG1
KVSVLTGIIKISLKT	VPS51	696	Q9UID3
RVLLTVLIAFTKKET	NAA35	241	Q5VZE5
VSTLLKEITTRKINF	PJVK	126	Q0ZLH3
ILIEVSLTKIEKVFS	USP35	301	Q9P2H5
TVSILLSIAVLFILK	SLCO1C1	651	Q9NYB5
QIIKTDSLVLTTLKT	SREBF2	246	Q12772
KIVAFTATSVLLVLL	SUSD4	321	Q5VX71
VITAVLIFLKRTLSK	VIPAS39	196	Q9H9C1
KKRIIKLLVSITVTF	GPR65	221	Q8IYL9
IFVKTLTGKTITLEV	UBC	231	P0CG48
IFVKTLTGKTITLEV	UBC	611	P0CG48
TRVVVLVLFTSVLKT	XK	221	P51811
KLILLITQVTASEKT	WDR43	571	Q15061