Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhydrolase activity, hydrolyzing O-glycosyl compounds

GBE1 GLB1 OTOGL MAN2B2 ASAH2 LCTL ASAH2B

2.01e-041032327GO:0004553
GeneOntologyMolecularFunctionhistone kinase activity

ATR AURKA PRKAA2 ATM

2.92e-04282324GO:0035173
GeneOntologyMolecularFunctionATP-dependent activity

MYO1G ERCC2 MYH11 ABCA4 SETX ABCA13 ABCA12 PEX6 KIF24 MYO3A ACSL6 TTF2 MYO18A RNF213 DDX51 SMARCA1 MYO15A DNAH11

3.17e-0461423218GO:0140657
GeneOntologyMolecularFunctionhistone H2AXS139 kinase activity

ATR ATM

4.00e-0432322GO:0035979
GeneOntologyMolecularFunctionadenosine-phosphate deaminase activity

AMPD2 AMPD3

4.00e-0432322GO:0047623
GeneOntologyMolecularFunctionAMP deaminase activity

AMPD2 AMPD3

4.00e-0432322GO:0003876
GeneOntologyMolecularFunctioncytoskeletal motor activity

MYO1G MYH11 KIF24 MYO3A MYO18A MYO15A DNAH11

4.62e-041182327GO:0003774
GeneOntologyBiologicalProcesscell-cell adhesion via plasma-membrane adhesion molecules

CDHR3 CD84 PTPRG PTPRS PKD1 SDK2 PCDHGB6 PCDHGA11 ADGRL1 LGALS9 CELSR3 SLITRK5 PCDH1 PCDH8

1.21e-0531323014GO:0098742
GeneOntologyCellularComponentchromosome passenger complex

INCENP AURKA AURKC

2.74e-0562353GO:0032133
GeneOntologyCellularComponentmeiotic spindle midzone

INCENP AURKC

1.26e-0422352GO:1990385
MousePhenoabnormal anterior eye segment morphology

ERCC2 AOC1 WBP1L SIPA1L3 UGGT1 BMS1 PEX6 PKD1L2 PCNX2 AURKA GJA3 FBXL18 RAB24 ALG14 PLCB1 GPNMB FAM135A OPLAH VCPIP1 EID2 KERA CYP4F2 MON1A PDCD7 HPS3 LCTL CSNK1G2 HHAT BSCL2 MYO15A CYP4F11 CYB561 CYBA

5.27e-06111718033MP:0005193
DomainMyosin_head_motor_dom

MYO1G MYH11 MYO3A MYO18A MYO15A

9.97e-05382315IPR001609
DomainMYOSIN_MOTOR

MYO1G MYH11 MYO3A MYO18A MYO15A

9.97e-05382315PS51456
DomainMyosin_head

MYO1G MYH11 MYO3A MYO18A MYO15A

9.97e-05382315PF00063
DomainMYSc

MYO1G MYH11 MYO3A MYO18A MYO15A

9.97e-05382315SM00242
DomainP-loop_NTPase

MYO1G ERCC2 MYH11 ABCA4 SETX ABCA13 ABCA12 BMS1 PEX6 KIF24 MYO3A SAMD9L TRANK1 RAB24 SULT2B1 TTF2 NDST2 MYO18A RNF213 DDX51 SMARCA1 MYO15A RAB21 DNAH11

1.42e-0484823124IPR027417
DomainCeramidse_alk_C

ASAH2 ASAH2B

1.52e-0422312PF17048
DomainNEUT/ALK_ceramidase_C

ASAH2 ASAH2B

1.52e-0422312IPR031331
DomainCeramidase_alk

ASAH2 ASAH2B

1.52e-0422312IPR006823
DomainFN3_dom

IL10RA PTPRG PTPRS RIMBP3C USH2A PAPPA2 SDK2 FSD1 RIMBP3B SORL1

2.85e-0420923110IPR003961
DomainABC_A

ABCA4 ABCA13 ABCA12

3.78e-04122313IPR026082
DomainConA-like_dom

BTNL8 USH2A PAPPA2 COL15A1 COMP FSD1 MAMDC4 LGALS9 THBS4 CELSR3

4.13e-0421923110IPR013320
DomainCOMP

COMP THBS4

4.53e-0432312PF11598
DomainAMPD

AMPD2 AMPD3

4.53e-0432312IPR006329
DomainRFX1_trans_act

RFX2 RFX3

4.53e-0432312IPR007668
DomainAur

AURKA AURKC

4.53e-0432312IPR030616
DomainRFX1_trans_act

RFX2 RFX3

4.53e-0432312PF04589
DomainThbs/COMP_coiled-coil

COMP THBS4

4.53e-0432312IPR024665
DomainFN3

PTPRG PTPRS RIMBP3C USH2A PAPPA2 SDK2 FSD1 RIMBP3B SORL1

5.07e-041852319SM00060
DomainCadherin-like

CDHR3 PCDHGB6 PCDHGA11 SGCA CELSR3 PCDH1 PCDH8

6.02e-041162317IPR015919
DomainSH3_2

STAC RIMBP3C DNMBP ARHGEF5 MYO15A RIMBP3B

6.92e-04862316PF07653
DomainSH3_2

STAC RIMBP3C DNMBP ARHGEF5 MYO15A RIMBP3B

6.92e-04862316IPR011511
DomainGPS

PKD1L2 PKD1 ADGRL1 CELSR3

7.90e-04342314SM00303
DomainGPS

PKD1L2 PKD1 ADGRL1 CELSR3

8.83e-04352314PF01825
DomainLamGL

USH2A PAPPA2

8.99e-0442312SM00560
DomainPecanex_C

PCNX2 PCNX1

8.99e-0442312PF05041
DomainLamG-like

USH2A PAPPA2

8.99e-0442312IPR006558
DomainREJ

PKD1L2 PKD1

8.99e-0442312PS51111
DomainPecanex

PCNX2 PCNX1

8.99e-0442312IPR007735
DomainA/AMP_deam_AS

AMPD2 AMPD3

8.99e-0442312IPR006650
DomainREJ_dom

PKD1L2 PKD1

8.99e-0442312IPR014010
DomainGPS

PKD1L2 PKD1 ADGRL1 CELSR3

9.84e-04362314PS50221
Domain-

ERCC2 ABCA4 SETX ABCA13 ABCA12 BMS1 PEX6 SAMD9L TRANK1 RAB24 SULT2B1 TTF2 NDST2 MYO18A RNF213 DDX51 SMARCA1 MYO15A RAB21 DNAH11

1.01e-03746231203.40.50.300
DomainGPS

PKD1L2 PKD1 ADGRL1 CELSR3

1.09e-03372314IPR000203
Domain-

USH2A PAPPA2 COMP LGALS9 THBS4 CELSR3

1.17e-039523162.60.120.200
DomainLH2

PKD1L2 PKD1 ALOXE3

1.33e-03182313SM00308
DomainTSP_3

COMP THBS4

1.49e-0352312PF02412
DomainGal_Lectin

PKD1L2 ADGRL1

1.49e-0352312PF02140
DomainTSP3

COMP THBS4

1.49e-0352312PS51234
DomainTSP_CTER

COMP THBS4

1.49e-0352312PS51236
DomainThrombospondin_3_rpt

COMP THBS4

1.49e-0352312IPR017897
DomainTSP_type-3_rpt

COMP THBS4

1.49e-0352312IPR028974
DomainLectin_gal-bd_dom

PKD1L2 ADGRL1

1.49e-0352312IPR000922
DomainFATC

ATR ATM

1.49e-0352312PF02260
Domain-

COMP THBS4

1.49e-03523124.10.1080.10
DomainThrombospondin_C

COMP THBS4

1.49e-0352312IPR008859
DomainTSP_C

COMP THBS4

1.49e-0352312PF05735
DomainSUEL_LECTIN

PKD1L2 ADGRL1

1.49e-0352312PS50228
DomainThrombospondin_3-like_rpt

COMP THBS4

1.49e-0352312IPR003367
Domain-

IL10RA BTNL8 OSCAR GBE1 CD84 FCRL3 PTPRG PTPRS RIMBP3C USH2A PAPPA2 SDK2 SGCA FSD1 CD1A LINGO1 RIMBP3B SORL1

1.56e-03663231182.60.40.10
Domain-

PKD1L2 PKD1 ALOXE3

2.11e-032123132.60.60.20
DomainPLAT

PKD1L2 PKD1 ALOXE3

2.11e-03212313PF01477
DomainPLAT/LH2_dom

PKD1L2 PKD1 ALOXE3

2.11e-03212313IPR001024
DomainPLAT

PKD1L2 PKD1 ALOXE3

2.11e-03212313PS50095
DomainA_DEAMINASE

AMPD2 AMPD3

2.21e-0362312PS00485
DomainA_deaminase

AMPD2 AMPD3

2.21e-0362312PF00962
DomainPKD/REJ-like

PKD1L2 PKD1

2.21e-0362312IPR002859
DomainFAT

ATR ATM

2.21e-0362312PS51189
DomainFATC

ATR ATM

2.21e-0362312PS51190
DomainREJ

PKD1L2 PKD1

2.21e-0362312PF02010
DomainFAT

ATR ATM

2.21e-0362312PF02259
DomainPIK-rel_kinase_FAT

ATR ATM

2.21e-0362312IPR003151
DomainFATC_dom

ATR ATM

2.21e-0362312IPR003152
DomainPIK_FAT

ATR ATM

2.21e-0362312IPR014009
DomainA/AMP_deaminase_dom

AMPD2 AMPD3

2.21e-0362312IPR001365
DomainFATC

ATR ATM

2.21e-0362312SM01343
Domain-

SEC24A ITIH2 COL6A1 CPNE5 CACNA2D4

2.23e-037423153.40.50.410
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

KDM5B SETX ATG13 SEC24A SIPA1L3 TSC2 MCCC1 SSRP1 TRIP12 RPTOR AFDN DNMBP DOCK6 HECTD1 VCPIP1 CASC3 AMPD2 ARHGEF5 FSD1 PRKAA2 CRYBG3 RAB21 DCP1A

2.63e-088612352336931259
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ERCC2 ANKRD9 SIPA1L3 PEX6 TSC2 PCNX2 DACT1 FAM83F PTPRS RPTOR PKD1 DNMBP DOCK6 HECTD1 ARSJ KMT5C MRPL55 POLRMT ADGRL1 NBPF1 MYOF CELSR3 CSNK1G2 PCNX1 HMGXB3

1.54e-0711052352535748872
Pubmed

Rheb binds and regulates the mTOR kinase.

ATR TSC2 RPTOR ATM

9.64e-0712235415854902
Pubmed

Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

TSC2 RPTOR PRKAA2

3.02e-065235323142078
Pubmed

AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation.

TSC2 RPTOR PRKAA2

3.02e-065235332912901
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SETX BMS1 KLHL9 TRANK1 RPTOR PLCB1 RPRD2 MED23 DNMBP DOCK6 SDK2 SPG11 CELSR3 PCNX1 HMGXB3

3.71e-065292351514621295
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

MYH11 AOC1 OSCAR GBE1 ACE ITIH2 SIAE GLB1 PTPRG SULT2B1 PTPRS FAM151A CRISPLD1 PAPPA2 COL6A1 COL15A1 MAN2B2 COMP CPNE5 MYOF THBS4 RAB21

4.19e-0610702352223533145
Pubmed

Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.

FAM83F GPNMB LDLRAD4 PAPPA2 COL15A1 KERA THBS4

4.83e-0698235719834535
Pubmed

Receptor protein tyrosine phosphatases are novel components of a polycystin complex.

PTPRG PTPRS PKD1

6.00e-066235321126580
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MYH11 SIPA1L3 NDRG2 ZNF462 ABRAXAS2 SAMD9L POM121 HECTD1 FAM135A MAN2B2 RNF213 MYOF SLITRK5 RAB21

7.72e-064932351415368895
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

WDR81 PEX6 TSC2 FAF2 RPTOR USP32 DOCK6 FAM135A FKBP15 SPG11 MON1A HPS3 PIGT PRKAA2

9.89e-065042351434432599
Pubmed

RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow.

RFX2 RFX3 DNAH11

1.04e-057235322233545
Pubmed

A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.

SSRP1 CSNK2A1 CSNK2A3

1.04e-057235311239457
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

MYH11 ATR UGGT1 BMS1 TRIP12 DOCK6 HECTD1 MYO18A MYOF

1.05e-05202235933005030
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

ABCA4 ANKRD9 SEC24A GBE1 RFTN2 KIF24 ABRAXAS2 STK32A AGO3 SLC25A29 MED23 LDLRAD4 AMPD3 ADAP1 MAN2B2 DUSP4 DDX51 BLZF1 HMGXB3 MYO15A RAB21 CYB561 CYBA

1.37e-0512422352330973865
Pubmed

p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.

SSRP1 CSNK2A1 CSNK2A3

1.66e-058235312393879
Pubmed

Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model.

NUF2 AURKA AURKC

1.66e-058235314602875
Pubmed

N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.

OSCAR SAMD9L FAF2 SLC25A29 CRISPLD1 VCPIP1 RFX2 CSNK1G2 PCNX1

1.85e-05217235934048709
Pubmed

TSC2 mediates cellular energy response to control cell growth and survival.

TSC2 PRKAG3 PRKAA2

2.48e-059235314651849
Pubmed

Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea.

MYO3A SLC26A5 MYO15A

2.48e-059235319339464
Pubmed

AMPK phosphorylation of raptor mediates a metabolic checkpoint.

RPTOR PRKAG3 PRKAA2

2.48e-059235318439900
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

ATR UGGT1 TSC2 PMEPA1 SIAE GLB1 PTPRS TTC13 HECTD1 COL6A1 COL15A1 MAN2B2 RNF213 KLHL11 MYOF PIGT CELSR3 SLITRK5 BSCL2 ATM RAB21 SORL1

2.50e-0512012352235696571
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

ERCC2 USP9X SEC24A WDR81 SSRP1 ABRAXAS2 AURKA AGO3 RPTOR RPRD2 DOCK6 TTF2 CASC3 FKBP15 EID2 MON1A BLZF1 CSNK2A1 DEPDC7 DCP1A

2.93e-0510382352026673895
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

UGGT1 BMS1 ABRAXAS2 PSMD6 AURKA FAF2 PTPRS AFDN TTC13 HECTD1 VCPIP1 FKBP15 NAGK DUSP4 POLRMT NT5DC2 CSNK2A1 PRKAA2 SORL1

3.96e-059742351928675297
Pubmed

Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks.

ATR ATM

4.55e-052235219285939
Pubmed

DNA damage induces a kinetochore-based ATM/ATR-independent SAC arrest unique to the first meiotic division in mouse oocytes.

ATR ATM

4.55e-052235228851706
Pubmed

Genomic structure and promoter analysis of the mouse neutral ceramidase gene.

ASAH2 ASAH2B

4.55e-052235212435403
Pubmed

CK2 phosphorylates SSRP1 and inhibits its DNA-binding activity.

SSRP1 CSNK2A1

4.55e-052235215659405
Pubmed

Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.

HHEX CSNK2A1

4.55e-052235228927755
Pubmed

A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease.

ASAH2 ASAH2B

4.55e-052235217334805
Pubmed

Induction of ATM/ATR pathway combined with Vγ2Vδ2 T cells enhances cytotoxicity of ovarian cancer cells.

ATR ATM

4.55e-052235224726882
Pubmed

rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis.

ATR ATM

4.55e-052235226061708
Pubmed

Acrofacial dysostosis in a patient with the TSC2-PKD1 contiguous gene syndrome.

TSC2 PKD1

4.55e-052235211836366
Pubmed

Functional significance for a heterogenous ribonucleoprotein A18 signature RNA motif in the 3'-untranslated region of ataxia telangiectasia mutated and Rad3-related (ATR) transcript.

ATR ATM

4.55e-052235220103595
Pubmed

Analysis of PKD1 for genomic deletion by multiplex ligation-dependent probe assay: absence of hot spots.

TSC2 PKD1

4.55e-052235218060739
Pubmed

Interplay between ATM and ATR in the regulation of common fragile site stability.

ATR ATM

4.55e-052235217934520
Pubmed

TSC2/PKD1 contiguous gene syndrome, with emphasis on a case with an atypical mild polycystic kidney phenotype and a novel genetic variant.

TSC2 PKD1

4.55e-052235231176519
Pubmed

ATM and ATR activities maintain replication fork integrity during SV40 chromatin replication.

ATR ATM

4.55e-052235223592994
Pubmed

Bleomycin-induced over-replication involves sustained inhibition of mitotic entry through the ATM/ATR pathway.

ATR ATM

4.55e-052235219527713
Pubmed

Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases.

ASAH2 ASAH2B

4.55e-052235210753931
Pubmed

ATM and ATR signaling at a glance.

ATR ATM

4.55e-052235226567218
Pubmed

A new link between transcriptional initiation and pre-mRNA splicing: The RNA binding histone variant H2A.B.

H2AB1 H2AB2

4.55e-052235228234895
Pubmed

Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis.

ATR ATM

4.55e-052235233742106
Pubmed

PKD1 Inhibits AMPKα2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells.

PKD1 PRKAA2

4.55e-052235226797128
Pubmed

Association study of AMP-activated protein kinase subunit genes in polycystic ovary syndrome.

PRKAG3 PRKAA2

4.55e-052235219574280
Pubmed

Diagnosis and genotype-phenotype correlation in patients with PKD1/TSC2 contiguous gene deletion syndrome.

TSC2 PKD1

4.55e-052235235142283
Pubmed

Polycystin 1 is required for the structural integrity of blood vessels.

TSC2 PKD1

4.55e-052235210677526
Pubmed

Histone variants at the transcription start-site.

H2AB1 H2AB2

4.55e-052235224768041
Pubmed

AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder.

AMPD2 AMPD3

4.55e-052235223911318
Pubmed

Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11.

CYP4F2 CYP4F11

4.55e-052235224138531
Pubmed

The mouse homologue of the polycystic kidney disease gene (Pkd1) is a single-copy gene.

TSC2 PKD1

4.55e-05223528661056
Pubmed

ATM acts downstream of ATR in the DNA damage response signaling of bystander cells.

ATR ATM

4.55e-052235218757420
Pubmed

In Vivo and In Vitro Effects of ATM/ATR Signaling Pathway on Proliferation, Apoptosis, and Radiosensitivity of Nasopharyngeal Carcinoma Cells.

ATR ATM

4.55e-052235228820634
Pubmed

ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle populations.

ATR ATM

4.55e-052235229279380
Pubmed

Renal Neoplasia in Polycystic Kidney Disease: An Assessment of Tuberous Sclerosis Complex-associated Renal Neoplasia and PKD1/TSC2 Contiguous Gene Deletion Syndrome.

TSC2 PKD1

4.55e-052235234876325
Pubmed

ATR regulates fragile site stability.

ATR ATM

4.55e-052235212526805
Pubmed

Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection.

ASAH2 ASAH2B

4.55e-052235235354041
Pubmed

Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.

ASAH2 ASAH2B

4.55e-052235224659784
Pubmed

Assignment of casein kinase 2 alpha sequences to two different human chromosomes.

CSNK2A1 CSNK2A3

4.55e-05223521577469
Pubmed

Investigation of switch from ATM to ATR signaling at the sites of DNA damage induced by low and high LET radiation.

ATR ATM

4.55e-052235224238855
Pubmed

ATM-activated autotaxin (ATX) propagates inflammation and DNA damage in lung epithelial cells: a new mode of action for silica-induced DNA damage?

ENPP2 ATM

4.55e-052235228968864
Pubmed

Imaging features of tuberous sclerosis complex with autosomal-dominant polycystic kidney disease: a contiguous gene syndrome.

TSC2 PKD1

4.55e-052235225355409
Pubmed

Association of AMP-activated protein kinase with risk and progression of non-Hodgkin lymphoma.

PRKAG3 PRKAA2

4.55e-052235223396962
Pubmed

Ataxia-Telangiectasia and RAD3-Related and Ataxia-Telangiectasia-Mutated Proteins in Epithelial Ovarian Carcinoma: Their Expression and Clinical Significance.

ATR ATM

4.55e-052235226124337
Pubmed

ATM regulates ATR chromatin loading in response to DNA double-strand breaks.

ATR ATM

4.55e-052235216461339
Pubmed

Inactivation of ATM/ATR DNA damage checkpoint promotes androgen induced chromosomal instability in prostate epithelial cells.

ATR ATM

4.55e-052235223272087
Pubmed

Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers.

ATR ATM

4.55e-052235230746633
Pubmed

Proficiency in homologous recombination repair is prerequisite for activation of G2-checkpoint at low radiation doses.

ATR ATM

4.55e-052235233640756
Pubmed

The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication.

ATR ATM

4.55e-052235229263259
Pubmed

An S/T-Q cluster domain census unveils new putative targets under Tel1/Mec1 control.

ATR ATM

4.55e-052235223176708
Pubmed

The ATM- and ATR-related SCD domain is over-represented in proteins involved in nervous system development.

ATR ATM

4.55e-052235226743489
Pubmed

Neutral ceramidase deficiency protects against cisplatin-induced acute kidney injury.

ASAH2 ASAH2B

4.55e-052235235151662
Pubmed

Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage.

ATR ATM

4.55e-052235215533933
Pubmed

ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling.

ATR ATM

4.55e-052235217124492
Pubmed

Identification of genetic drivers of plasma lipoprotein size in the Diversity Outbred mouse population.

ASAH2 ASAH2B

4.55e-052235237944753
Pubmed

The association of ATR protein with mouse meiotic chromosome cores.

ATR ATM

4.55e-052235210382071
Pubmed

Role of neutral ceramidase in colon cancer.

ASAH2 ASAH2B

4.55e-052235227609772
Pubmed

Expression variations of DNA damage response genes ATM and ATR in blood cancer patients.

ATR ATM

4.55e-052235237338595
Pubmed

Using ZINC08918027 inhibitor to determine Aurora kinase-chromosomal passenger complex isoforms in mouse oocytes.

AURKA AURKC

4.55e-052235235255953
Pubmed

Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney.

ASAH2 ASAH2B

4.55e-052235211328816
Pubmed

TMEPAI family: involvement in regulation of multiple signalling pathways.

PMEPA1 LDLRAD4

4.55e-052235229945215
Pubmed

Novel insights into the mechanism of cell cycle kinases Mec1(ATR) and Tel1(ATM).

ATR ATM

4.55e-052235234151669
Pubmed

Clinical and genetic findings in a cohort of Chinese patients with autosomal recessive spinocerebellar ataxia.

SETX ENPP2

4.55e-052235231743419
Pubmed

Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation.

ASAH2 ASAH2B

4.55e-052235219345744
Pubmed

Lactosylceramide contributes to mitochondrial dysfunction in diabetes.

ASAH2 ASAH2B

4.55e-052235226900161
Pubmed

Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2.

CSNK2A1 CSNK2A3

4.55e-052235214646071
Pubmed

Aurora kinase genetic polymorphisms: an association study in Down syndrome and spontaneous abortion.

AURKA AURKC

4.55e-052235235218477
Pubmed

Inhibition of Atm and/or Atr disrupts gene silencing on the inactive X chromosome.

ATR ATM

4.55e-052235216213462
Pubmed

ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle.

ATR ATM

4.55e-052235227442013
Pubmed

XPD mutations in trichothiodystrophy hamper collagen VI expression and reveal a role of TFIIH in transcription derepression.

ERCC2 COL6A1

4.55e-052235223221806
Pubmed

Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death.

ASAH2 ASAH2B

4.55e-052235226747710
Pubmed

Angiotensin-converting enzyme and p22(phox) polymorphisms and the risk of coronary heart disease in a low-risk Spanish population.

ACE CYBA

4.55e-052235215193812
Pubmed

Computational study of the potential impact of AURKC missense SNPs on AURKC-INCENP interaction and their correlation to macrozoospermia.

INCENP AURKC

4.55e-052235236326488
Pubmed

Urinary β-galactosidase stimulates Ca2+ transport by stabilizing TRPV5 at the plasma membrane.

GLB1 TRPV5

4.55e-052235226747426
Pubmed

Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agents.

ATR ATM

4.55e-052235225483091
Pubmed

Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit.

CSNK2A1 CSNK2A3

4.55e-052235212860116
Pubmed

AMP deaminase 3 plays a critical role in remote reperfusion lung injury.

AMPD2 AMPD3

4.55e-052235223542464
Pubmed

Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids.

ASAH2 ASAH2B

4.55e-052235216380386
Pubmed

COMP and TSP-4 interact specifically with the novel GXKGHR motif only found in fibrillar collagens.

COMP THBS4

4.55e-052235230464261
Pubmed

Method for systematic targeted isolation of homologous cDNA fragments in a multiplex format.

JPH4 ADGRA1

4.55e-052235215152599
GeneFamilyATP binding cassette subfamily A

ABCA4 ABCA13 ABCA12

1.83e-04141483805
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-4|TCGA-Lung / Sample_Type by Project: Shred V9

SEC24A CD84 STK32A SAMD9L COL15A1 COMP PTTG1IP2 RASGRF2 RNF213 MYOF

3.69e-08176236100923b01137d6f9956ca815b41102c81e82624065
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PMEPA1 OLFML3 GPNMB CRISPLD1 COL6A1 UTS2R MAN2B2 COMP KERA THBS4

8.37e-0819223610b35f0e422070ba9c7c1d9ff3eace4edc10286cde
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

KDM5B ATR USP9X TASOR2 USP32 MED23 HECTD1 KLHL11 PCNX1 CRYBG3

8.79e-0819323610abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA4 ABCA13 ABCA12 PKD1L2 TRANK1 OTOGL USH2A MYO15A DNAH11

6.36e-0718423692cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA4 ABCA13 ABCA12 PKD1L2 TRANK1 OTOGL USH2A MYO15A DNAH11

6.36e-0718423692b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA4 ABCA13 ABCA12 PKD1L2 TRANK1 OTOGL USH2A MYO15A DNAH11

6.36e-071842369ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Heart-Unknown-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA4 ABCA12 NUF2 TRANK1 OTOGL TOGARAM2 CCNB3 MYO15A

8.85e-0714123684aa4b3476dc5abefbd348353cfe711cd5fe3d52f
ToppCellfacs-Heart-Unknown-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA4 ABCA12 NUF2 TRANK1 OTOGL TOGARAM2 CCNB3 MYO15A

8.85e-071412368e40c6f1b7fbaa46b3eaa55f1b37ef360b04370a8
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP9X ENPP2 UGGT1 STK32A FAM151A SCNN1B USH2A FAM135A SDK2

9.07e-0719223695b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCellfacs-Heart-Unknown-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA4 ABCA12 NUF2 TRANK1 OTOGL TOGARAM2 CCNB3 MYO15A

9.33e-071422368759fbbd15b4fb313bd6269b7f087edafebd530ef
ToppCellSepsis-Int-URO-Lymphocyte-T/NK-CD4+_CTL|Int-URO / Disease, condition lineage and cell class

XKR9 INCENP NUF2 TASOR2 FAM83F PLCB1 ASAH2 CCNB3 ASAH2B

1.17e-061982369717735d755745439f97ba1b71785c73945dfa9c5
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SETX ENPP2 ACE PMEPA1 PTPRG AFDN DOCK6 FAM135A RNF213

1.27e-062002369dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellE16.5-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IL10RA MYO1G SNX20 CD84 SAMD9L MAN2B2 SLC25A33 CYBA

4.84e-061772368f55332fe7fc32c23892ccf08b6b4d5b1ffcc0d3f
ToppCellE16.5-Immune-Immune_Myeloid-DC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IL10RA MYO1G SNX20 CD84 SAMD9L MAN2B2 SLC25A33 CYBA

4.84e-061772368235254c08b44c20ee3cb62dd2ca0c7e46a2587e3
ToppCellE16.5-Immune-Immune_Myeloid-DC-cDC2|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IL10RA MYO1G SNX20 CD84 SAMD9L MAN2B2 SLC25A33 CYBA

4.84e-061772368b59d9fcf0a4964ef2d6274b6021a69cf7d335e0a
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP9X UGGT1 GDPD2 FAM151A SCNN1B FAM135A SDK2 PCNX1

5.04e-061782368fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYH11 OLFML3 PAPPA2 COL6A1 COMP SGCA KERA APCDD1L

5.70e-061812368eea943fdcbef0bbaa8578f3296923e874893b405
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYH11 OLFML3 PAPPA2 COL6A1 COMP SGCA KERA APCDD1L

5.70e-0618123689c157de9d3403e092c907599f2a2c16db5b21131
ToppCellB_cells-ISG-high_B_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

SAMD9L TRANK1 CPNE5 RFX3 LGALS9 CD1A SLC15A2 APCDD1L

6.18e-061832368dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYH11 OLFML3 PAPPA2 COL6A1 COMP SGCA KERA APCDD1L

6.18e-061832368bc7dd6a40ec9c773d005c1a46f305d40cdd0a326
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RFTN2 NDRG2 STK32A PLCB1 CRISPLD1 SDK2 COL15A1 HHAT

6.70e-0618523688ed10ba581849c9c4ac4397226be2b62b4b3b900
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANKRD9 ACE STK32A MED23 FAM135A CRISPLD1 ARSJ CYB561

6.70e-06185236887151ab95530e70d61328b336518df58db584acb
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

NDRG2 SLCO1C1 PTPRG OTOGL PLCB1 DOCK6 DUSP4 NT5DC2

7.24e-06187236886250acf088ec0c4800a0dfa031b0d4f7e52c342
ToppCellPCW_07-8.5-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

HHEX ACE COL15A1 RASGRF2 CPNE5 LGALS9 PCDH1 CYB561

7.24e-06187236829b2e2be26a9d72b154760e47acf61cfe2f45fa7
ToppCell15-Distal-Mesenchymal-Pericyte|Distal / Age, Tissue, Lineage and Cell class

STAC GJA3 MYO3A PLCB1 SGCA DUSP4 LINGO1 ELAVL3

7.53e-0618823684963382e54aac06bf5047c7d725393db70667ee7
ToppCelldroplet-Heart-nan-24m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 ACE NDRG2 PMEPA1 OLFML3 GPNMB COL6A1 COL15A1

8.46e-0619123681f660ea2841324d13f63e01f1789e606c2843fc4
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IL10RA OLFML3 CD84 SAMD9L GBGT1 GPNMB RNF213 SORL1

8.78e-061922368935a4a36881a9fa4daa02cba96af07f6686ed8d6
ToppCellCV-Healthy-1|Healthy / Virus stimulation, Condition and Cluster

IL10RA SAMD9L FBXO6 PLP2 DUSP4 RNF213 LGALS9 CACNA2D4

8.78e-0619223682a2052b44e8f679ef484f03ba4fb37b0ec841b88
ToppCelldroplet-Heart-nan-24m-Mesenchymal-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 ACE NDRG2 PMEPA1 OLFML3 GPNMB COL6A1 COL15A1

9.12e-061932368d08919db9601941569b9a143dad4d8e6f56a4389
ToppCelldroplet-Heart-nan-24m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 ACE NDRG2 PMEPA1 OLFML3 GPNMB COL6A1 COL15A1

9.12e-0619323680ca0439dfdcb2361ca8d1015fb874a5b5c635d31
ToppCellcellseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NDRG2 SULT2B1 SCNN1B DUSP4 SLC15A2 NT5DC2 PRKAA2 MUC6

9.47e-0619423685402835d6b252276e458001949dd1cb5aa744b0e
ToppCellcellseq-Epithelial-Epithelial_Airway-Secretory/RAS|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NDRG2 SULT2B1 SCNN1B DUSP4 SLC15A2 NT5DC2 PRKAA2 MUC6

9.47e-0619423682c0236a102f7fec6d508afec6137da5b26a65931
ToppCellMesenchymal_cells-Arteriolar_fibro.|Mesenchymal_cells / Lineage and Cell class

OLFML3 ITIH2 GPNMB COL6A1 UTS2R COL15A1 COMP THBS4

1.06e-051972368cb321836980e7b4efbb9284c6af7ccd34079d2be
ToppCelllymphoid-T_cell-Regulatory_T_cell|T_cell / Lineage, cell class and subclass

IL10RA MYO1G PTGER2 ZNF462 FCRL3 PLP2 CYB561 CYBA

1.10e-0519823686773c6043ef4a3d9e9700330b6386431ee66abdc
ToppCelldroplet-Limb_Muscle-nan-3m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PMEPA1 OLFML3 CRISPLD1 COL6A1 UTS2R COMP KERA THBS4

1.14e-051992368edd5300da1a3b758210ff8f949e9d1988b8bc7e2
ToppCellBiopsy_Control_(H.)-Epithelial-MUC5B+|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

NDRG2 SULT2B1 SCNN1B HSD11B2 SPINK5 SLC15A2 NT5DC2 PRKAA2

1.14e-0519923684ab45996e6bca406c77895a5998982b8ab1cf210
ToppCell(2)_Fibroblasts|World / Cell class and subclass of bone marrow stroma cells in homeostatis

PMEPA1 PLP2 COL6A1 UTS2R COL15A1 COMP KERA THBS4

1.14e-051992368777423b413376b0d3fbd92ff51dd0133fb54d293
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IL10RA OLFML3 CD84 SAMD9L RNF213 LGALS9 MYOF SORL1

1.14e-051992368e7faf7d0cb43cf93149c446e5f718f84fa85477c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-Z|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

OLFML3 CD84 SAMD9L NAGK LGALS9 ATM SORL1

1.25e-0514523679743d68ba8bfef56fd9a979ab357c0e287eb5ae2
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1|343B / Donor, Lineage, Cell class and subclass (all cells)

IL10RA BMS1 TTC13 RASGRF2 NDST2 CPNE5 ATM

1.49e-0514923672a7f71da51c85e04de2123164914122480e60d66
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

GDPD2 ERFE PTPRG PTPRS PKD1 MTERF3 DNAH11

2.27e-051592367b1d5ebd0c186b6d0279dab20d8f3b4a915acdc1f
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Il33_(Il33)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

OLFML3 ITIH2 GBGT1 DNMBP COL15A1 PCDHGB6

2.27e-051072366d446ffbe93cd49669f1cf91411aae07cc15d9e2a
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Il33_(Il33)|Hippocampus / BrainAtlas - Mouse McCarroll V32

OLFML3 ITIH2 GBGT1 DNMBP COL15A1 PCDHGB6

2.27e-0510723665c9e745d0b08a4aa1f3a93f9cc094fac57061a30
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IL10RA MYO1G SNX20 CD84 MPPE1 RNF213 MYO15A

2.46e-0516123675a8698790f9aba796dd2b64af419055c60bd7de8
ToppCellmetastatic_Brain-T/NK_cells-Cytotoxic_CD8+_T|T/NK_cells / Location, Cell class and cell subclass

HHEX OSCAR AURKC ADGRL1 MLYCD SLC15A2 SMARCA1

2.46e-051612367e6e294b4ba911c1327664f1a0f93207096c6de03
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO1G SNX20 PTGER2 ERFE FCRL3 TOGARAM2 CELSR3

2.77e-051642367ba85f7b21ae34e285d286ada24715885ca6329f7
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO1G SNX20 PTGER2 ERFE FCRL3 TOGARAM2 CELSR3

2.77e-051642367649e42d9cfdec2f7771d1e938b516e46e7d07078
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEC24A ZNF462 CRISPLD1 COL6A1 SDK2 COMP SMARCA1

2.99e-05166236781c546c6d847e49e662b81e71992ca0f7a99e890
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte-Chondrocyte_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEC24A ZNF462 CRISPLD1 COL6A1 SDK2 COMP SMARCA1

2.99e-05166236737794a84601a2a949d579663d4a4bb8bc8fb5923
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Lhx8-Inhibitory_Neuron.Gad1Gad2-Chat_(Nucleus_basalis_(NB))|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ABCA4 PTGER2 SULT2B1 LRRC75A ARSJ SLC18A3

3.09e-05113236679ba2eb8f85e5da4c19c838df881c18ffdc450fb
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Lhx8|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ABCA4 PTGER2 SULT2B1 LRRC75A ARSJ SLC18A3

3.09e-05113236691d55fe6fb1c1472867d74461f5b9e4f17db01cd
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Lhx8-Inhibitory_Neuron.Gad1Gad2-Chat_(Nucleus_basalis_(NB))-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ABCA4 PTGER2 SULT2B1 LRRC75A ARSJ SLC18A3

3.09e-05113236634ae3dec5ec7585d155ea61de6adc42aa4f45226
ToppCellfacs-Liver-Non-hepatocytes-24m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL10RA MYO1G SNX20 ACE ADAP1 NECAP2 CYBA

3.35e-0516923672d3618f78484bd3508b7bdae3a0d0183cdae5057
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RFTN2 ACE PLCB1 CRISPLD1 COL15A1 RASGRF2 FGF23

3.35e-0516923670d8b681404e18f3061d84425fb5f7d84e8e2b8d7
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 ABCA12 TRANK1 OTOGL USH2A SPINK5 DNAH11

3.35e-05169236712bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATR FASTKD5 NDRG2 FKBP15 ADAP1 THBS4 DEPDC7

3.48e-051702367833b4f44ea1fa673dfc6b43ce45a79fe68ae3b05
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

INCENP NUF2 ERFE FAM83F GPNMB TTF2 CELSR3

3.61e-051712367845f312f8cbe29d820da25f0e6d75deb382bbfd8
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IL10RA ANKRD9 BMS1 TTC13 DNMBP RASGRF2 NDST2

3.75e-051722367d65ffff3e341af34a043a0d802d7ba4b69de36e9
ToppCellfacs-Liver-Non-hepatocytes-24m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL10RA MYO1G SNX20 ACE ADAP1 NECAP2 CYBA

3.75e-05172236766823536288c7009ce01b5177794a3e874e94570
ToppCellCOVID-19_Mild-PLT_2|COVID-19_Mild / Disease Group and Platelet Clusters

CDHR3 TSC2 MCCC1 AMPD3 SDK2 MRPL55 MYOF

3.89e-051732367d11705e56b6b21eec963ea224717f27680c781ed
ToppCell390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ACE CD84 PLP2 ACSL6 DUSP4 CPNE5 MYOF

4.18e-0517523676374ab186d7ccf7f6dfb858267edba8962789e15
ToppCellCF-Lymphoid-pDC|CF / Disease state, Lineage and Cell class

ENPP2 PMEPA1 PTPRS TTC13 SLC25A29 SDK2 SLITRK5

4.34e-051762367dd1e529a9e413bcaab43584afbe059e1464ffb53
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RFTN2 ACE PTPRG PLCB1 COL15A1 RASGRF2 FGF23

4.50e-05177236712f8627124acbf436e75681ff1ce429ff5e3f256
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-capillary_endothelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RFTN2 ACE PTPRG PLCB1 COL15A1 RASGRF2 FGF23

4.50e-051772367fdf2af00fc971f0cd3915e1416e4a256458d6ea8
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel-D175|Adult / Lineage, Cell type, age group and donor

ENPP2 RFTN2 AURKC PLCB1 COL15A1 MYO18A CPNE5

4.50e-051772367c9f269765c7d5d29caab75910e51645606ed562e
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.6.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

OSCAR ACE STAC GBGT1 RIMBP3C GPNMB FKBP15

4.50e-051772367929cd8f530ce001623735da53b7278d02522e2b5
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

STK32A HSD11B2 CRISPLD1 COL6A1 CRYBG3 TRPV5 SORL1

4.50e-051772367c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCell3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NDRG2 OLFML3 GPNMB CRISPLD1 COL6A1 THBS4 APCDD1L

5.18e-051812367e1ae9ada60ec89e7a7cde9c231c1a099ed2ffecc
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STAC SCNN1B SLC25A29 HSD11B2 ARSJ APCDD1L TRPV5

5.36e-051822367f96095b81188b52db8fcfca4837129cfcd9bd7b7
ToppCelldroplet-Heart-4Chambers-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OSCAR ACE NDRG2 PMEPA1 OLFML3 COL6A1 COL15A1

5.36e-051822367f4b74c2756989812abe4e7055ec8918f69d56025
ToppCell10x5'v1-week_17-19-Myeloid_DC-DC-DC3|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

IL10RA NDRG2 GLB1 PLP2 DCAF4L1 OVOL3 CYBA

5.55e-051832367c6cac433ea7a3d60728efdc7051e09e01bb3ade5
ToppCellB_cells-ABCs|B_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

MYO1G HHEX SAMD9L ADAP1 DUSP4 RFX2 LGALS9

5.55e-051832367bf9c6fe3ce4e44e4056027257eab8448c39c4fb8
ToppCellMild/Remission-B_intermediate-10|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

IL10RA CD84 FCRL3 SLC25A29 DNMBP ADAP1 DUSP4

5.55e-051832367278064c9f0582463b83bf156d34e77f60187613b
ToppCellwk_08-11-Hematologic-Myeloid-Non-cla._mono.|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

IL10RA MYO1G SNX20 OSCAR CD84 GPNMB LGALS9

5.75e-051842367324f91b70913bda3509e234aaf23b46fad91e076
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RFTN2 NDRG2 STK32A PLCB1 CRISPLD1 SDK2 COL15A1

5.95e-051852367b8052cebb73f41abe6faf0aa847be7c8ef23ae94
ToppCell368C-Myeloid-Macrophage-FABP4+_Macrophage_3|368C / Donor, Lineage, Cell class and subclass (all cells)

OSCAR ACE STAC SAMD9L GPNMB FKBP15 LGALS9

6.15e-051862367ddfadd43efeac3b3e6b7062590cc2b8f2f2db2ab
ToppCellFrontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr-Oligodendrocyte.Tnf.Igsf8_(Ctps)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

NAGS FAM83F USH2A CACNA2D4 LCTL

6.25e-057923654c9c3051cb8a9c39c6df20e3fe37242db4b44280
ToppCellFrontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr-Oligodendrocyte.Tnf.Igsf8_(Ctps)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

NAGS FAM83F USH2A CACNA2D4 LCTL

6.25e-05792365eddad041c0bc6952d9c68a36bdd78f6d661f0e58
ToppCellfacs-Heart-LA-24m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 ACE NDRG2 PMEPA1 OLFML3 GPNMB COL6A1

6.36e-0518723671669df899b1759c338ffce196fe009840123cfcd
ToppCellwk_20-22-Hematologic_Lymphocytic-T_&_ILC-ILC2|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

IL10RA MYO1G GATA1 PTGER2 CD84 FCRL3 PLP2

6.36e-051872367dd5183d2c620b2a87253a9783b70c5df2c36c570
ToppCellfacs-Heart-LA-24m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 ACE NDRG2 PMEPA1 OLFML3 GPNMB COL6A1

6.36e-051872367f3ef3f5a761f8306edc39bf16e76e44aae6fa7f6
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MYH11 MYO3A SLCO1C1 PLCB1 DOCK6 DUSP4 MYOF

6.36e-051872367a2bf958ea59c359a265bfa437d59315e1920cdd4
ToppCellPCW_13-14-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

HHEX ACE COL15A1 CPNE5 LGALS9 PCDH1 CYB561

6.58e-051882367b66f1f08827dd6c48583d871f9f33ea41e48bfb2
ToppCellfacs-Thymus-Epithelium-3m-Mesenchymal|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 OLFML3 DACT1 OPLAH COL6A1 THBS4 CYB561

6.80e-0518923671db5dd1ef2a65251af2d5696622d1dd9c4ae2b55
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-bronchial_smooth_muscle_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH11 ENPP2 ZNF462 PTCHD1 CRISPLD1 ACSL6 ARHGEF5

6.80e-0518923674dc32b463546bbe7250dddd281b92ad17ec22da1
ToppCellfacs-Thymus-Epithelium-3m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 OLFML3 DACT1 OPLAH COL6A1 THBS4 CYB561

6.80e-05189236714833feea8f80744a06ece73f813eaeff8c4dd61
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Endothelial_Myeloid|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HHEX OLFML3 CD84 SAMD9L LGALS9 MYOF CYBA

6.80e-051892367e9fe8d17f4b7cca9bbf3655047e27b2fec5060c1
ToppCellfacs-Thymus-Epithelium-3m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 OLFML3 DACT1 OPLAH COL6A1 THBS4 CYB561

6.80e-051892367bfb1c183a8a2752a2368b74150e66181c6a9da48
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Airway_Smooth_Muscle|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH11 ENPP2 ZNF462 PTCHD1 CRISPLD1 ACSL6 ARHGEF5

6.80e-0518923670d06bf0d7191d13a1c4f30a7881e7ea1093bfd6f
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IL10RA MYO1G PTGER2 FCRL3 TTC13 RNF213 ATM

7.03e-051902367d153a0bdedcd6865e6ee19575234a78b5d859ff1
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

OLFML3 ITIH2 COL6A1 COL15A1 COMP KERA

7.38e-051322366893b7ec2a2d8a140cc98575d1beca1189f053e9a
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AOC1 SCNN1B SLC25A29 HSD11B2 APCDD1L MUC6 SORL1

7.51e-051922367d5ec4cdb15620a5abfc83577353501186c2bc86a
ToppCell11.5-Airway-Mesenchymal-Cartilage|Airway / Age, Tissue, Lineage and Cell class

NDRG2 DACT1 PLP2 CRISPLD1 SDK2 COL15A1 COMP

7.76e-051932367d4779d92a4dd4b8b656383e6f4fce76d3bd70931
ToppCell18-Distal-Mesenchymal-Cartilage|Distal / Age, Tissue, Lineage and Cell class

RFTN2 NDRG2 STK32A DACT1 CRISPLD1 COL15A1 COMP

7.76e-05193236752f3d1bb8d8ca91ba12439d46392f377928ff8f8
ToppCellfacs-Tongue-nan-3m-Epithelial-keratinocyte|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDM5B ABCA12 NDRG2 SULT2B1 AFDN SPINK5 PCDH1

7.76e-05193236733437fdb417d78463caee14a9f0e094da1733829
ToppCellMonocytes-Tissue-resident_macrophages|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis

NDRG2 OLFML3 CD84 PCNX2 FAM135A LDLRAD4 SORL1

7.76e-051932367198552810dcac8d0ca63a78badd6702b49ff6edf
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

OSCAR OLFML3 CD84 GPNMB LGALS9 MYOF SORL1

7.76e-051932367697518bab1338dc441b2d93b410d957e692f20e6
ToppCellMesenchymal_cells-Arteriolar_fibro.|World / Lineage and Cell class

OLFML3 ITIH2 GPNMB COL6A1 COL15A1 COMP THBS4

8.01e-051942367c1e8923a50b4138a1e4c054c0c17b7f7122aa8a9
ToppCellEpithelial_cells-Club_cells|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

NDRG2 SCNN1B DUSP4 LGALS9 SLC15A2 PRKAA2 CYBA

8.27e-051952367b758676abfc4e6930b696d270ecc0ea461b87a54
ToppCelldroplet-Limb_Muscle-MUSCLE-1m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GLRX5 PTPRS COL6A1 COL15A1 KERA PIGT NT5DC2

8.27e-051952367fee9d13f48149cd5f921cfe4b8b3053cf6a6dbd2
DiseaseProstatic Neoplasms

ERCC2 ATR ACE AURKA GUCD1 FAF2 SULT2B1 RPRD2 SPINK5 NAGK COL15A1 ARHGEF5 NDST2 PDP1 SMARCA1 ALOXE3 ATM PCDH8

1.29e-0661622418C0033578
DiseaseMalignant neoplasm of prostate

ERCC2 ATR ACE AURKA GUCD1 FAF2 SULT2B1 RPRD2 SPINK5 NAGK COL15A1 ARHGEF5 NDST2 PDP1 SMARCA1 ALOXE3 ATM PCDH8

1.29e-0661622418C0376358
Diseaseataxia telangiectasia (implicated_via_orthology)

ATR ATM

5.74e-0522242DOID:12704 (implicated_via_orthology)
DiseasePolycystic kidneys, severe infantile with tuberous sclerosis

TSC2 PKD1

5.74e-0522242C1838327
DiseaseCongenital Nonbullous Ichthyosiform Erythroderma

ABCA12 SULT2B1 ALOXE3

6.81e-05112243C0079154
DiseasePeroxisome biogenesis disorder

PEX6 PEX16

1.71e-0432242cv:C1832200
Diseasemyocardial infarction (biomarker_via_orthology)

ACE PLCB1 HSD11B2 UTS2R CSNK2A1 CSNK2A3 CYBA

2.31e-041602247DOID:5844 (biomarker_via_orthology)
DiseaseIchthyosis Congenita I

ABCA12 ALOXE3

3.41e-0442242C4551630
DiseaseHarlequin Fetus

ABCA12 ALOXE3

3.41e-0442242C0239849
DiseaseIchthyosis Congenita II

ABCA12 ALOXE3

3.41e-0442242C3536797
Diseaseautosomal recessive congenital ichthyosis 1 (is_implicated_in)

ABCA12 ALOXE3

3.41e-0442242DOID:0060656 (is_implicated_in)
DiseaseCollodion Fetus

ABCA12 ALOXE3

3.41e-0442242C3543867
Diseaselate-onset Alzheimers disease

ZNF462 PTPRS USP32 OPLAH LINGO1 CSNK2A1 ATM SORL1 CYB561

4.20e-042922249EFO_1001870
DiseaseCongenital ichthyosis

ABCA12 ALOXE3

5.65e-0452242C0020758
Diseasepontocerebellar hypoplasia (implicated_via_orthology)

AMPD2 AMPD3

5.65e-0452242DOID:0060264 (implicated_via_orthology)
DiseaseMalignant neoplasm of breast

HHEX ABCA4 AURKA FCRL3 FAM83F OTOGL SCNN1B PLCB1 GPNMB UTS2R PCDHGB6 RASGRF2 RFX2 MAMDC4 ZNF546 PRKAA2 ATM PCDH8 SORL1

5.87e-04107422419C0006142
Diseaseapolipoprotein B measurement

ERCC2 WDR81 PEX6 PMEPA1 NAGS NKPD1 DOCK6 AMPD2 DUSP4 MLYCD MYOF RAB21 ASAH2B DNAH11

5.89e-0466322414EFO_0004615
Diseaseaxial length measurement, refractive error

GBE1 RASGRF2

8.43e-0462242EFO_0005318, MONDO_0004892
DiseaseStargardt's disease

ABCA4 ITIH2

8.43e-0462242C0271093
DiseaseColorectal Carcinoma

ERCC2 ABCA4 ABCA13 ABCA12 AURKA DACT1 SULT2B1 PTPRS SCNN1B GPNMB RASGRF2 HPS3 CCNB3 SORL1

1.02e-0370222414C0009402
Diseaseazoospermia (implicated_via_orthology)

PTPRS NDST2 BSCL2

1.10e-03272243DOID:14227 (implicated_via_orthology)
DiseaseColorectal Neoplasms

ERCC2 ABCA4 ABCA13 ABCA12 AURKA DACT1 SULT2B1 GPNMB

1.32e-032772248C0009404
DiseaseCone-Rod Dystrophy 2

ABCA4 AIPL1 CACNA2D4

1.36e-03292243C3489532
DiseaseHeadache

ATG13 RNF213 FGF23 HHAT

1.44e-03642244HP_0002315
DiseaseCiliopathies

TSC2 AIPL1 SCNN1B USH2A DNAH11

1.55e-031102245C4277690
DiseasePena-Shokeir syndrome type I

GBE1 SLC18A3

1.56e-0382242C1276035
Diseaseperoxisomal biogenesis disorder (is_implicated_in)

PEX6 PEX16

1.56e-0382242DOID:0080377 (is_implicated_in)
Diseasehexadecenedioate (C16:1-DC) measurement

CYP4F2 CYP4F11

1.99e-0392242EFO_0800562
DiseaseX-21467 measurement

SLCO1C1 DNMBP

1.99e-0392242EFO_0020007
DiseaseStomach Neoplasms

ERCC2 ATR WDR46 ACE PTPRG FSD1 ATM MUC6

2.05e-032972248C0038356
DiseaseMalignant neoplasm of stomach

ERCC2 ATR WDR46 ACE PTPRG FSD1 ATM MUC6

2.18e-033002248C0024623
Diseasesenile cataract (is_implicated_in)

ERCC2 ATM

3.02e-03112242DOID:9669 (is_implicated_in)
DiseasePEROXISOME BIOGENESIS DISORDER 1A (ZELLWEGER)

PEX6 PEX16

3.02e-03112242C4721541
DiseaseCongenital ichthyosis of skin

ABCA12 ALOXE3

3.02e-03112242cv:C0020758
DiseaseNonsyndromic Deafness

MYO3A OTOGL SLC26A5 MYO15A

3.41e-03812244C3711374
Diseaseretinitis pigmentosa (is_implicated_in)

ABCA4 AIPL1 USH2A

3.72e-03412243DOID:10584 (is_implicated_in)
Diseaseresponse to anticoagulant

CDHR3 PMEPA1 CYP4F2

3.72e-03412243GO_0061476
Diseasetestosterone measurement

HHEX AOC1 WBP1L WDR81 NUF2 RFTN2 PMEPA1 DACT1 PTPRG PLCB1 MED23 DNMBP USH2A CASC3 AMPD3 ARSJ MLYCD PRKAG3 MYO15A

4.10e-03127522419EFO_0004908
Diseasemigraine disorder, Headache

ZNF462 RPRD2 RNF213 FGF23

4.22e-03862244HP_0002315, MONDO_0005277
DiseaseZellweger Spectrum

PEX6 PEX16

4.24e-03132242C3658299
DiseaseZellweger-Like Syndrome

PEX6 PEX16

4.24e-03132242C0751594
DiseaseInfantile Refsum Disease (disorder)

PEX6 PEX16

4.24e-03132242C0282527
Diseaseresponse to ketamine, dissociation measurement

RASGRF2 TOGARAM2

4.24e-03132242EFO_0009748, EFO_0009750
Diseaseleukemia (is_implicated_in)

ACE ACSL6

4.24e-03132242DOID:1240 (is_implicated_in)
DiseaseNeoplasm of uncertain or unknown behavior of bladder

ERCC2 ATM

5.64e-03152242C0496930
Diseasemyelodysplastic syndrome (implicated_via_orthology)

GATA1 SAMD9L

5.64e-03152242DOID:0050908 (implicated_via_orthology)
DiseaseBenign neoplasm of bladder

ERCC2 ATM

5.64e-03152242C0154017
DiseaseCarcinoma in situ of bladder

ERCC2 ATM

5.64e-03152242C0154091
DiseasePeroxisome biogenesis disorders

PEX6 PEX16

5.64e-03152242C1832200
DiseaseAdrenoleukodystrophy, Neonatal

PEX6 PEX16

5.64e-03152242C0282525
Diseasephosphatidylinositol measurement

INCENP SLCO1C1 PLCB1 DOCK6

6.01e-03952244EFO_0010230
Diseaseautism spectrum disorder (implicated_via_orthology)

KDM5B TSC2 KMT5C NDST2 ELP2

6.19e-031522245DOID:0060041 (implicated_via_orthology)
DiseaseCongenital total cataract

SIPA1L3 DNMBP

6.42e-03162242C0266539
DiseaseMyasthenic Syndromes, Congenital, Slow Channel

ALG14 SLC18A3

6.42e-03162242C0751885
Diseaseneutrophil collagenase measurement

ABCA13 DNMBP

6.42e-03162242EFO_0008248
DiseaseZellweger Syndrome

PEX6 PEX16

6.42e-03162242C0043459
Diseaseautosomal recessive polycystic kidney disease (implicated_via_orthology)

ACE PKD1

6.42e-03162242DOID:0110861 (implicated_via_orthology)
Diseasehearing impairment

MYO3A USH2A SLC26A5 MYO15A

6.70e-03982244C1384666
DiseaseNonsyndromic Hearing Loss and Deafness, Autosomal Recessive

MYO3A SLC26A5 MYO15A

6.88e-03512243cv:CN043650
DiseaseBenign neoplasm of stomach

ATR ATM

7.24e-03172242C0153943
DiseaseCongenital Myasthenic Syndromes, Postsynaptic

ALG14 SLC18A3

7.24e-03172242C0751883
DiseaseNeoplasm of uncertain or unknown behavior of stomach

ATR ATM

7.24e-03172242C0496905
DiseaseRenal Insufficiency

ACE CYBA

7.24e-03172242C1565489
DiseaseAmyotrophic lateral sclerosis

SETX SPG11

7.24e-03172242cv:C0002736
DiseaseCarcinoma in situ of stomach

ATR ATM

7.24e-03172242C0154060
DiseaseHereditary Diffuse Gastric Cancer

ERCC2 WDR46 ACE PTPRG FSD1 ATM MUC6

7.30e-032932247C1708349

Protein segments in the cluster

PeptideGeneStartEntry
RRPVPISYHQLEAFY

PTPRG

271

P23470
YLVELSPGRRNHFAY

AFDN

386

P55196
ELHLAYYLQSQPRGF

MAMDC4

561

Q6UXC1
PAYRLSRKQGHEYVI

ATG13

136

O75143
PNILRLYNYFHDARR

AURKC

101

Q9UQB9
HALEYVLFRPNRRYN

ABRAXAS2

141

Q15018
PGIVKAYYVRARAHA

AIPL1

261

Q9NZN9
SHLRHPNILRLYGYF

AURKA

186

O14965
PNILRLYGYFHDATR

AURKA

191

O14965
HENRLPTYFRGYESP

CRYBG3

1921

Q68DQ2
EHLYLYARLRGVPAE

ABCA4

2031

P78363
QPLYLNLHAYVRRAL

ACE

846

P12821
FILVLHRYYRSPLVQ

PRKAG3

246

Q9UGI9
RLNGEHLYFTLNPRF

BTNL8

381

Q6UX41
PSHNQIYGRAFIYLQ

ABCA12

1011

Q86UK0
YHLRVRRKNPVTGNY

PRKAA2

436

P54646
YVAARHTTTYRLPNR

ADGRL1

196

O94910
YQVRRPSHEGYLAAP

ADGRL1

1441

O94910
HAPDFRRVYLPYVTN

ARHGEF5

1256

Q12774
AQPGIYRIRYFGHNR

ASAH2B

126

P0C7U1
LQHRPQVGYIRVRFY

COMP

686

P49747
EGHYAQRLSRTAPVY

H2AB1

41

P0C5Y9
EGHYAQRLSRTAPVY

H2AB2

41

P0C5Z0
TVYRRHGRAYVPIAQ

GPNMB

211

Q14956
CVYFLGTYVQLRRHP

ADGRA1

191

Q86SQ6
RRHYRPTGYQRPLQS

APCDD1L

231

Q8NCL9
RYLFLGNPDHALVYQ

DNAH11

656

Q96DT5
VYYVLPHAVRLLQGV

ABCA13

1746

Q86UQ4
LRLTPGHYQRAETYF

ABCA13

4256

Q86UQ4
YRNFRHPEIVGYSVP

DNMBP

1466

Q6XZF7
THLYQSSARRYAGPL

ELAVL3

216

Q14576
RAARFHYLQVAFPGA

ADAP1

226

O75689
IGRYYSSREPLLNHL

DEPDC7

306

Q96QD5
PAPAYYAHLVAFRAR

AGO3

801

Q9H9G7
LGSLSNAYSPRHYVI

ALG14

56

Q96F25
FLSYHRNPLPEYLSR

AMPD2

741

Q01433
LIIQRYVEGYFLHPT

AOC1

201

P19801
HYYLPEGLRRRFLQA

HSD11B2

351

P80365
SLRSRYRPQHIFFGA

CYB561

151

P49447
FQTIPLYYIEDHNGR

BMS1

951

Q14692
HEPFLLYRNASLSIY

DCP1A

91

Q9NPI6
DIYSTYHLFPPRQLN

DCPS

111

Q96C86
SDYPRGVRYILFQHG

FBXO6

221

Q9NRD1
INIPIAYHFLRRYAR

CCNB3

1256

Q8WWL7
ARLAYHRFPRITSQY

AMPD3

166

Q01432
YFQVPDRLGILTHLY

NAGK

191

Q9UJ70
AGQERFHALGPIYYR

RAB21

76

Q9UL25
RYVHDRFLVGPYQNT

RAB24

26

Q969Q5
VGQRKHLPASYLYRV

RFTN2

86

Q52LD8
YTFQGLCPGTHYRVR

RIMBP3B

1041

A6NNM3
YTFQGLCPGTHYRVR

RIMBP3C

1041

A6NJZ7
ALPYFPRRYGAHASL

OLFML3

361

Q9NRN5
PRRYGAHASLRYNPR

OLFML3

366

Q9NRN5
RYGPQFTLQHVPDYR

PCDHGA11

881

Q9Y5H2
PSYIYGAQHLLRLFV

MSL3P1

371

P0C860
RYGPQFTLQHVPDYR

PCDHGB6

876

Q9Y5F9
RPYRFHGTCTYILLQ

MUC6

411

Q6W4X9
KNIGRFHPYTRYENI

BLZF1

371

Q9H2G9
ARGTPLSQAIIHQYY

INCENP

846

Q9NQS7
LGSYEHRIYLQPGRL

ITIH2

191

P19823
THVYRYLRAFLPESG

KMT5C

91

Q86Y97
ERNYHIFYELLAGLP

MYO15A

1406

Q9UKN7
TRLHRLINPNFYGYQ

MYO15A

2671

Q9UKN7
YPFPRTVNDYTHALL

HHEX

101

Q03014
LCSEYRHYVRNGRLP

SPINK5

566

Q9NQ38
DHYVLEYRRTNFEGP

FSD1

196

Q9BTV5
YRYASFRNLVDPITH

LRRC75A

96

Q8NAA5
RARGVLAIPNYHYRD

ALOXE3

496

Q9BYJ1
PLQAPGRYFEHYRSI

ARSJ

271

Q5FYB0
AQPGIYRIRYFGHNR

ASAH2

741

Q9NR71
LFEYYHRLRNLPTIN

LGALS9

326

O00182
SRAPQLHLEYRFYKQ

CSNK1G2

81

P78368
YGVRQSVPYHQAALL

JPH4

141

Q96JJ6
QPFRYISGSIHYSRV

GLB1

46

P16278
QHYGFVLYRTTLPQD

GLB1

411

P16278
YALVPRYRGLFHHIS

MLYCD

131

O95822
SFHVYVLRNLYVPNR

DCAF4L1

111

Q3SXM0
EGIRRYAHELQFEYP

CD1A

96

P06126
GPFTRNYYVRAVLHL

CYBA

81

P13498
RQRPIAFDNATHYYL

HMGXB3

1216

Q12766
TSAPVLLQHYPLYRR

MPPE1

241

Q53F39
GSLQDRYVPYHSARI

FAM135A

1421

Q9P2D6
HGHNRIIAYSRPVYF

PCNX1

1061

Q96RV3
IHGHNQIITYSRPIY

PCNX2

896

A6NKB5
PFRQYYLQAEHSLPA

PDCD7

426

Q8N8D1
LGHFTTRYITERNYP

LCTL

341

Q6UWM7
RALQIVYGIRLEHFY

NUF2

51

Q9BZD4
PRYGTALVHLYVNET

PCDH1

801

Q08174
HFRLQPAYAGSYLVV

PCDH8

436

O95206
RQRYGASLLHTYAGP

MYO18A

426

Q92614
LSIGHPYFYQRRVSR

PTGER2

136

P43116
NYDGVLYRHFQIPRV

PEX6

336

Q13608
VERRALHELGVYYLP

ERFE

216

Q4G0M1
LGNHTAREYRILLYI

FKBP15

101

Q5T1M5
LYVYHLVGPFLQRFQ

MED23

1246

Q9ULK4
IPIIQRISHVSGYNY

KIF24

186

Q5T7B8
PRYQHGIAVIGNFLY

KLHL9

336

Q9P2J3
PYFLARYSILHANVV

ERCC2

191

P18074
TAVPYLAVRHLVYLR

LINGO1

276

Q96FE5
LRRPPQNHTYYDTFV

GDPD2

356

Q9HCC8
HVYRLDNYSRVVFPV

GABRE

476

P78334
VTLDLYHSNGYRARV

IL10RA

86

Q13651
IRGHYERILNPYNLF

KDM5B

171

Q9UGL1
LRPRLHSIYVSEGYN

NAGS

411

Q8N159
PDGRDHARLYYILLA

AP5B1

606

Q2VPB7
PYRSAFYILEQQRVG

NBPF1

926

Q3BBV0
QSRLRYTPHPAYATF

PDP1

41

Q9P0J1
QRERFHRFQPTYPYL

PMEPA1

126

Q969W9
GYDAYVTFPVRQPRH

PLP2

126

Q04941
LLLVAYGQRDPSAYH

PKD1L2

1961

Q7Z442
NRVYFYGRRETVPIH

PTTG1IP2

131

P0DTF9
THNGALVGYSVRYRP

PTPRS

646

Q13332
LYREGVAAPLQYRHS

OSCAR

161

Q8IYS5
YVYHIRGFPLATQLN

PRR27

86

Q6MZM9
KVHGQPASYAYRERR

OVOL3

171

O00110
GLHNFLIRYVYIPVG

HHAT

341

Q5VTY9
ITPRRRYPIHQAQYS

POM121

226

Q96HA1
YYSVAQVGIPDLRHF

MON1A

531

Q86VX9
HLFGVYPSRAGNYLR

PAPPA2

66

Q9BXP8
AEAYRHSPVFQVYPL

GATA1

66

P15976
PDYQGHFIVLRGYNR

GUCD1

181

Q96NT3
YFRLYLKPSQDVHRV

ATM

171

Q13315
RYIVLHFGRSLQYGN

ATR

2066

Q13535
FYHPGQEYNVRVASR

CSNK2A3

181

Q8NEV1
IPSAYTLRHARGYGR

HECTD1

1146

Q9ULT8
HNGRPYSLLVYIPSR

GBE1

676

Q04446
RVFLQLRPEYRVHSY

FASTKD5

116

Q7L8L6
ILRLHGVRDYAAYNV

GLRX5

76

Q86SX6
ACHVRIPYRYLHGTQ

KLHL11

656

Q9NVR0
LIALYGYDIRSAHNP

CASC3

236

O15234
VYRYPSPLHAVAVQS

DACT1

266

Q9NYF0
PAREVYAPHTSYRNL

DOCK6

536

Q96HP0
QLAAYVHYAFRLPGT

DOCK6

831

Q96HP0
VAYGESHLFRVPSYQ

COL6A1

996

P12109
RVHYYIFTDNPAAVP

GBGT1

141

Q8N5D6
NYYSRGHRSIPGVAI

GJA9

381

P57773
DAPQYLRTYVHRVGR

DDX51

581

Q8N8A6
VDRTRVYYRLPQGYH

FAM151A

561

Q8WW52
NGYILSHPDLRPLYR

CACNA2D4

561

Q7Z3S7
HLYIVERANPGFIYQ

CDHR3

141

Q6ZTQ4
NPHYARVIGTRVYSD

CRISPLD1

426

Q9H336
VYHSPQYHFLVSLGR

FGF23

126

Q9GZV9
LHTDFLYYLTPDGQR

CYP4F11

241

Q9HBI6
AYAHYLLATFPRRAL

ANKRD9

86

Q96BM1
LHIDFLYYLTPDGQR

CYP4F2

241

P78329
FYHPGQEYNVRVASR

CSNK2A1

181

P68400
FLRHYLENYPIAPGR

EID2

156

Q8N6I1
PRYRGILDCVHQSYR

SLC25A29

226

Q8N8R3
SLRGSPPILYRFYHE

FCRL3

406

Q96P31
LRYSLRQYNIVGLHT

MCCC1

451

Q96RQ3
TIPGLSYRHYNIRPT

MAN2B2

531

Q9Y2E5
YTYAIRSRLTHVPQG

MAN2B2

676

Q9Y2E5
GFRYLNYRIHTSPSQ

KRTAP13-3

126

Q3SY46
YAVHAVYQRRTSDPA

ELP2

111

Q6IA86
RRYPRYHSNLFRGQD

CELSR3

2341

Q9NYQ7
YYAHTAAPLGQARAV

GJA3

271

Q9Y6H8
RIQLYGAYLRIHAHF

BSCL2

206

Q96G97
HQRIILYYTEPGSHV

COL15A1

131

P39059
PFLYLGSAYHAARRD

DUSP4

201

Q13115
YPHRLNLFYLANDVI

RPRD2

71

Q5VT52
SAYRTVQRGEYPAVH

SLC15A2

546

Q16348
RVTHYLPNVTLEYRV

SDK2

941

Q58EX2
HEQRSYPFIRDEGIY

SCNN1B

321

P51168
RLVPVLYHVYSFRNV

POLRMT

601

O00411
HLLYGRPAVLYRTRY

ENPP2

596

Q13822
LEAYHRSLRTVQLYG

CPNE5

416

Q9HCH3
HSLPAVRQYLFSLYE

PSMD6

251

Q15008
RCHYRGSVYQPGELI

OTOGL

801

Q3ZCN5
ARLTAYVTGNPAHYL

PKD1

1311

P98161
HLFLTYLGRAQYDPA

MTERF3

366

Q96E29
LLGLRYQEYVTRHPA

PEX16

6

Q9Y5Y5
YNIYLHGRLYLRTPG

USH2A

2566

O75445
FGHLAASRLQYYVPR

USP9X

1651

Q93008
RAAQFVTRHPINEYY

SORL1

336

Q92673
GVYLTVRLAARYPHL

SLC18A3

341

Q16572
KGYHIRNQTYRRFPS

TEX55

476

Q96M34
GRNPRDVVVSLYHYS

SULT2B1

146

O00204
ARYKAPFHQLRIQYG

SMARCA1

941

P28370
GVYHRNPLIRKYAAE

TOGARAM2

616

Q6ZUX3
HLLYRRFAPDISSYV

HPS3

291

Q969F9
GAGAYILARYALNHP

NDRG2

146

Q9UN36
GIRRHYGALPFSVYS

NKPD1

81

Q17RQ9
EGVSLPRSSLYNHYL

RFX2

211

P48378
GVSLPRSTLYNHYLR

RFX3

196

P48380
HRLYSDLQTPGRYGR

PTCHD1

81

Q96NR3
RYNEGHALYLAFLAR

RASGRF2

6

O14827
RYTGVRIIHPLIALY

SAMD9L

981

Q8IVG5
LYNPLTRVYGEPHRR

SEC24A

466

O95486
AATQRYYVERPIFSH

SLC26A5

11

P58743
AFPEHGSVYEYRRAQ

OPLAH

1271

O14841
HYQNLRVFYARLAPG

FBXL18

226

Q96ME1
RVFYARLAPGYINQE

FBXL18

231

Q96ME1
HRIYSYVVSRPQPRG

FAF2

76

Q96CS3
FSYGPHLRYLRLDGN

KERA

316

O60938
HGPQYQYRIIFRTRE

SIPA1L3

541

O60292
RPVPVRFHNYGDYFN

SETX

1731

Q7Z333
RHLYDTLQYPIGLIA

SIAE

201

Q9HAT2
VTHRNYYERIHALGP

CD84

76

Q9UIB8
VTAYELLRGRRPYHI

STK32A

211

Q8WU08
ALENRVGIYSPHTAY

NIF3L1

116

Q9GZT8
YRQLSLAGRVGLHYS

FAM83F

301

Q8NEG4
LRYTQRSPHHPGFLY

SGCA

76

Q16586
KLDYFHNGNPRYTRV

RPTOR

1056

Q8N122
SSRLALRTVYYPQVH

SLC25A33

41

Q9BSK2
RGRYDIRIYPTFLHL

SSRP1

211

Q08945
IYIRSQPVAQIYVHG

ACSL6

576

Q9UKU0
NYLNVLPGEFYITRH

C12orf4

406

Q9NQ89
VLHNLRERYFSGLIY

MYH11

101

P35749
RLQAREGHRYYAPLL

SNX20

256

Q7Z614
RLNFAYYLHNGRPSF

SPG11

1196

Q96JI7
LEAIQAYLAGHYRVP

RNF213

1956

Q63HN8
VIPNSHVYYRRGLAL

RPF1

166

Q9H9Y2
QHRPQVGYIRVRFYE

THBS4

886

P35443
QPSARLYRHRGTLYF

TTC13

246

Q8NBP0
GELSTLLYNTHPYRA

PIGT

366

Q969N2
AYTFSPNYDLRRPHQ

SLITRK5

886

O94991
TRVHRQAYARLYPVL

MRPL55

41

Q7Z7F7
RLYDSNVFRHIYLGL

SLCO1C1

631

Q9NYB5
GFRRYYSSPLLIHEQ

STAC

166

Q99469
YLIQHLRIHTGERPY

ZNF546

231

Q86UE3
QRAHGDPVALNYTFY

NDST2

716

P52849
DYNPSFAIRGLHYDI

NT5DC2

111

Q9H857
FHYVQLGTAYRGLQP

NT5DC2

136

Q9H857
HQYFYRRTGVIGVQP

VCPIP1

436

Q96JH7
FGPYRLNYSRTGRHL

WDR46

196

O15213
AIRPGYHYICLRNER

PLCB1

766

Q9NQ66
YPLLHTQYGRTHIRE

ZNF677

246

Q86XU0
NPFLYTLLTRNYRDH

UTS2R

311

Q9UKP6
PYINTRIHGVLTHYQ

ZNF462

1521

Q96JM2
PYVQIRDLHGILRTY

TASOR2

1911

Q5VWN6
GYYRAGYSLLRLHQP

TRANK1

51

O15050
GYSLLRLHQPYEAAR

TRANK1

56

O15050
ITRYDLYHTFRPAVL

TMEM147

156

Q9BVK8
RHRLQFYIGEHLLPY

TRIP12

1341

Q14669
LNPYQILRYYFGHGR

WDR87

761

Q6ZQQ6
LIAYREAHNYSALPF

WBP1L

81

Q9NX94
YLIVHQRIHTGERPY

ZNF583

366

Q96ND8
QPLTQYFISGRHLYE

USP32

756

Q8NFA0
YFPALHRFILLYQAR

WDR81

876

Q562E7
GKINYVFRHYIFNPR

UGGT1

221

Q9NYU2
AFRRSPRNLIYFGEH

TRPV5

151

Q9NQA5
ARLPHLYRNFAAEQY

TSC2

851

P49815
VYLYHGPNRDSRARV

TTF2

671

Q9UNY4
LIVYYGSFHPNRSAE

XKR9

336

Q5GH70
RFSRFQPTYPYVQHE

LDLRAD4

151

O15165
LYERPPHLYAVANAA

MYO1G

71

B0I1T2
ALSDHPNVVRFYGIY

MYO3A

71

Q8NEV4
LAYARIPAHQVLYST

MYOF

786

Q9NZM1
VHVYRIPPRATNRGY

NECAP2

16

Q9NVZ3