Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainSPIN/Ssty

SPIN2A SPIN2B SPIN3

1.71e-0651053IPR003671
DomainSpin-Ssty

SPIN2A SPIN2B SPIN3

1.71e-0651053PF02513
DomainSPIN-2

SPIN2A SPIN2B

3.13e-0521052IPR029564
DomainTalin-1

TLNRD1 TLN1

9.36e-0531052IPR015710
DomainLUC7

LUC7L LUC7L2

9.36e-0531052PF03194
DomainLuc7-rel

LUC7L LUC7L2

9.36e-0531052IPR004882
DomainSpectrin

TRIO SYNE1 SPTBN4

2.82e-04231053PF00435
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

HSPG2 TRIO GRK5 GRK6 UBE3B BCR JAK3 NHSL1 TLNRD1 TLN1 TMEM132A OGDHL DISP2 PLCG1 ZC3H7B FEM1A HECTD1

4.78e-0811051071735748872
Pubmed

A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1.

SPIN2A SPIN2B SPIN3

5.62e-076107329061846
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

CUL3 MYBBP1A HK1 MYO1D TRIO MYO5B SYNE1 HAPLN2 DAPK3 BCR SPTBN4 NHSL1 ICAM5 TLN1 TJP2 OGDHL

7.88e-0614311071637142655
Pubmed

Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.

DOCK4 MYBBP1A GRK5 GRK6 BCR SPIN3

9.20e-06156107622952844
Pubmed

Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.

GRK5 GRK6

9.38e-062107217786238
Pubmed

Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation.

GRK5 GRK6

9.38e-062107220038610
Pubmed

Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression.

SPIN2A SPIN2B

9.38e-062107212145692
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

DOCK4 STIM2 NAA15 TRIO DAPK3 BCR NHSL1 LUC7L TJP2 HECTD1 AQR KIF1C

1.42e-058611071236931259
Pubmed

Congenital Muscular Dystrophy Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY

SYNE1 CRPPA LARGE1

1.87e-0517107320301468
Pubmed

Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6.

GRK5 GRK6

2.81e-05310727789183
Pubmed

G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.

GRK5 GRK6

2.81e-053107219801552
Pubmed

Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation.

TNFSF11 TJP2

2.81e-053107222437732
Pubmed

Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.

GRK5 GRK6

2.81e-053107212032308
Pubmed

Central region of talin has a unique fold that binds vinculin and actin.

TLNRD1 TLN1

2.81e-053107220610383
Pubmed

Differential and nonredundant roles of phospholipase Cgamma2 and phospholipase Cgamma1 in the terminal maturation of NK cells.

JAK3 PLCG1

2.81e-053107217015722
Pubmed

Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms.

LUC7L LUC7L2

2.81e-053107233852859
Pubmed

Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium.

GRK5 GRK6

2.81e-053107210467231
Pubmed

Disruption of perlecan binding and matrix assembly by post-translational or genetic disruption of dystroglycan function.

HSPG2 LARGE1

2.81e-053107216098969
Pubmed

Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN).

GRK5 GRK6

2.81e-053107218662895
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

CUL3 HK1 NAA15 GPS1 PRPF6 LUC7L TLN1 CLNS1A OGDHL PLCG1

3.49e-056531071033742100
Pubmed

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.

HAPLN2 THBD TNFSF11 SEMA5B BST1 PLCG1

4.91e-05210107616537572
Pubmed

G-protein receptor kinases 2, 5 and 6 redundantly modulate Smoothened-GATA transcriptional crosstalk in fetal mouse hearts.

GRK5 GRK6

5.60e-054107229969579
Pubmed

Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder.

GRK5 GRK6

5.60e-054107221784156
Pubmed

Association of gene polymorphisms with the risk of warfarin bleeding complications at therapeutic INR in patients with mechanical cardiac valves.

THBD VKORC1

5.60e-054107224602049
Pubmed

Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases.

GRK5 GRK6

5.60e-054107211504827
Pubmed

Lyn inhibits osteoclast differentiation by interfering with PLCgamma1-mediated Ca2+ signaling.

TNFSF11 PLCG1

5.60e-054107219285079
Pubmed

Protein interactome reveals converging molecular pathways among autism disorders.

MYO5B HLA-DRB5 GPS1 SPTBN4 LUC7L LUC7L2 SPRYD3 NECAB3 KIF1C

6.04e-05560107921653829
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

CUL3 KRT85 GPS1 PRPF6 BCR LUC7L CLNS1A SPRYD3 TJP2 FEM1A HECTD1 AQR

6.34e-0510051071219615732
Pubmed

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

CUL3 JAK3 TLN1 TJP2 PLCG1 ZC3H7B QARS1

7.11e-05327107715592455
Pubmed

c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes.

GRK5 GRK6

9.32e-055107227232975
Pubmed

Aberrantly expressed recoverin is functionally associated with G-protein-coupled receptor kinases in cancer cell lines.

GRK5 GRK6

9.32e-055107212507501
Pubmed

Disruption of the talin gene arrests mouse development at the gastrulation stage.

HSPG2 TLN1

9.32e-055107211084655
Pubmed

Three mechanisms assemble central nervous system nodes of Ranvier.

HAPLN2 SPTBN4

9.32e-055107223664614
Pubmed

Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL.

BCR TLN1

9.32e-05510727534286
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

MYBBP1A STIM2 HK1 MYO1D MYO5B SYNE1 GRK5 GRK6 GPS1 PRPF6 SPTBN4 ZC3H7A OGDHL ATP11C

1.38e-0414421071435575683
Pubmed

beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.

GRK5 GRK6

1.40e-04610729826657
Pubmed

Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity.

GRK5 GRK6

1.40e-04610729211925
Pubmed

β-arrestin-biased agonism of β-adrenergic receptor regulates Dicer-mediated microRNA maturation to promote cardioprotective signaling.

GRK5 GRK6

1.40e-046107229627294
Pubmed

Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins.

STIM2 BST1

1.40e-046107211463338
Pubmed

beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress.

GRK5 GRK6

1.40e-046107220530803
Pubmed

Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions.

GRK5 GRK6

1.40e-046107236451830
Pubmed

The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation.

GRK5 GRK6

1.40e-046107210506199
Pubmed

Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes.

GRK5 GRK6

1.40e-046107217060617
Pubmed

A protein interaction landscape of breast cancer.

DOCK4 MYBBP1A HK1 TRIO MYO5B GPS1 XRCC2 MTX2 TLN1

1.54e-04634107934591612
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MYBBP1A HK1 NAA15 MYO1D PRPF6 TLN1 TJP2 HECTD1 AQR

1.92e-04653107922586326
Pubmed

Partial structure, chromosome localization, and expression of the mouse Icln gene.

THBD CLNS1A

1.95e-04710729073507
Pubmed

Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.

GRK5 GRK6

1.95e-04710728672451
Pubmed

A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction.

BCR PLCG1

1.95e-04710721383690
Pubmed

Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.

GRK5 GRK6

1.95e-047107211517230
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DOCK4 SYNE1 DENND4B TLN1 DISP2 AQR LARGE1

2.73e-04407107712693553
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

CUL3 DOCK4 MYO1D TRIO BCR ZC3H7A LUC7L2 TLN1 TJP2 KIF1C

3.08e-048531071028718761
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

MYBBP1A MYO1D MYO5B SYNE1 GRK6 PRPF6 LUC7L TLN1 TJP2 QARS1 AQR

3.23e-0410241071124711643
Pubmed

Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling.

JAK3 PLCG1

3.33e-04910729045636
Pubmed

The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling.

BCR PLCG1

3.33e-04910728995379
Pubmed

Toll-like receptors differentially regulate GPCR kinases and arrestins in primary macrophages.

GRK5 GRK6

3.33e-049107218180038
Pubmed

Retinal ganglion cell axon sorting at the optic chiasm requires dystroglycan.

HSPG2 CRPPA

3.33e-049107230149005
Pubmed

Synucleins are a novel class of substrates for G protein-coupled receptor kinases.

GRK5 GRK6

4.15e-0410107210852916
Pubmed

Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function.

CUL3 GPS1

4.15e-0410107226976604
Pubmed

Network organization of the human autophagy system.

CUL3 STIM2 HK1 NAA15 KRT85 LUC7L2 TJP2

4.18e-04437107720562859
Pubmed

Mapping of unconventional myosins in mouse and human.

MYO1D MYO5B MXI1

4.43e-044810738884266
Pubmed

cDNA cloning and expression analysis of new members of the mammalian F-box protein family.

FBXL7 FBXL2

5.06e-0411107210945468
Pubmed

SVEP1 is an endogenous ligand for the orphan receptor PEAR1.

HSPG2 TLN1

5.06e-0411107236792666
Pubmed

The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.

CUL3 SYNE1

5.06e-0411107227621083
Pubmed

C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.

MYBBP1A NAA15 PRPF6 TLN1

5.12e-04119107435776542
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

DOCK4 TRIO PHETA1 PRPF6 BCR MTX2 LUC7L2 TLN1 TJP2 SPIN3

5.38e-049161071032203420
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

CUL3 MYBBP1A PRPF6 ZC3H7A OGDHL ZC3H7B QARS1 HECTD1 AQR

5.73e-04759107935915203
Pubmed

Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.

TCF19 MXI1

6.07e-0412107223955597
Pubmed

AGO61-dependent GlcNAc modification primes the formation of functional glycans on α-dystroglycan.

CRPPA LARGE1

6.07e-0412107224256719
Pubmed

A conserved acetylation switch enables pharmacological control of tubby-like protein stability.

CUL3 GPS1 BCR PHKA1 NHSL1

6.48e-04223107533187986
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

MYO5B SPTBN4 TMEM132A HECTD1

7.14e-04130107412421765
Pubmed

Overexpression of COP9 signalosome subunits, CSN7A and CSN7B, exerts different effects on adipogenic differentiation.

CUL3 GPS1

7.15e-0413107227833851
Pubmed

Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction.

HSPG2 HK1 MYO1D BCR

7.35e-04131107428634551
Pubmed

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

BCR ICAM5 TJP2 PLCG1

7.78e-04133107415144186
Pubmed

Pediatric Genetic Cholestatic Liver Disease Overview

MYO5B TJP2

8.33e-0414107236108118
Pubmed

Dystroglycan organizes axon guidance cue localization and axonal pathfinding.

HSPG2 CRPPA

8.33e-0414107223217742
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

CUL3 MYBBP1A NAA15 SYNE1 GPS1 PRPF6 TLN1 RECQL4 CCDC97 AQR KIF1C

8.75e-0411551071120360068
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

MYBBP1A PRPF6 SEMA5B SPIN2A ZC3H7B KIF1C LARGE1

8.80e-04496107731343991
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

HSPG2 HSPB3 TRIO SYNE1 LUC7L TLN1 MRFAP1L1

8.90e-04497107723414517
Pubmed

Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1.

MYBBP1A HK1 LUC7L2 QARS1 KIF1C

9.18e-04241107523125841
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

CUL3 NAA15 UBE3B BCR LUC7L2 RECQL4 ZC3H7B AQR

9.19e-04650107838777146
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

MYO1D DAPK3 PRPF6 TLN1 CCDC97 QARS1 AQR

9.88e-04506107730890647
Pubmed

CAND1 enhances deneddylation of CUL1 by COP9 signalosome.

CUL3 GPS1

1.09e-0316107216036220
Pubmed

Ontogeny of stromal organizer cells during lymph node development.

HSPG2 TNFSF11

1.09e-0316107220237296
Pubmed

Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution.

PGLYRP2 FEM1A

1.09e-0316107211441184
Pubmed

Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting.

JAK3 TNFSF11

1.09e-0316107210687308
Pubmed

Consequences of COP9 signalosome and 26S proteasome interaction.

CUL3 GPS1

1.09e-0316107216045761
Pubmed

Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.

DOCK4 MYBBP1A MYO1D PRPF6 LUC7L2 CLNS1A

1.22e-03383107629331416
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CUL3 CECR2 BCR FBXL7 SEMA5B MAML2 ZC3H7B

1.28e-03529107714621295
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

CUL3 DOCK4 TRIO GPS1 NHSL1 USHBP1 DENND4B MAML2

1.33e-03689107836543142
Pubmed

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.

CUL3 DPY19L3 PGLYRP2 NHSL1 MTX2 TJP2 ATP11C

1.33e-03533107725544563
Pubmed

Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.

TMEM151B LAG3 XRCC2 JAK3 ICAM5

1.35e-03263107519773279
Pubmed

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth.

FBXL7 FBXL2

1.39e-0318107228614300
Pubmed

Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.

SPTBN4 TLN1

1.39e-0318107212119179
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

MYBBP1A MYO1D MYO5B PRPF6 LUC7L LUC7L2 TLN1 CLNS1A QARS1 HECTD1 AQR

1.61e-0312471071127684187
Pubmed

The DNA sequence of the human X chromosome.

MOSPD1 SPIN2A ATP11C SPIN2B DNASE1L1 SPIN3

1.66e-03407107615772651
Pubmed

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.

CHST8 NCR3

1.72e-0320107219079260
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

CUL3 MYBBP1A NAA15 MYO1D MYO5B KRT85 DAPK3 PRPF6 TJP2 QARS1 AQR

1.72e-0312571071136526897
Pubmed

Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.

PRPF6 TMEM132A NECAB3 ZC3H7B AQR

1.86e-03283107518854154
Pubmed

The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.

DOCK4 CLNS1A SPIN2A AQR

1.88e-03169107423084401
Pubmed

Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.

CUL3 GPS1

1.90e-0321107211337588
CytobandXp11.1

SPIN2A SPIN2B

3.22e-0541072Xp11.1
GeneFamilyTudor domain containing|Spindlin family

SPIN2A SPIN2B SPIN3

4.62e-0756631089
GeneFamilyTudor domain containing

SPIN2A SPIN2B SPIN3

3.30e-0437663780
GeneFamilyADAM metallopeptidase domain containing|CD molecules

LAG3 NCR3 THBD TNFSF11 BST1 C5AR1 KIR3DL2

5.70e-04394667471
GeneFamilyF-box and leucine rich repeat proteins

FBXL7 FBXL2

2.64e-0321662558
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MYO1D TRIO SYNE1 MAML2 FBXL2 LARGE1

6.26e-06188107663a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCellControl-Endothelial-Endothelial-Gen_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK4 STIM2 MYO1D THBD FBXL7 L3MBTL4

7.27e-061931076e1d546165dcc2392f540162206852c4717d7306f
ToppCellInfluenza_Severe-NK|World / Disease group and Cell class

SYNE1 LAG3 ACOT4 NCR3 FUT11 KIR3DL2

8.17e-061971076565d578f7a28a19175d56663bf30c60e0d5e1b22
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK4 MYO1D TRIO NHSL1 MAML2 L3MBTL4

8.41e-0619810761996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellBAL-Control-cDC_12|Control / Compartment, Disease Groups and Clusters

TCF19 GRK5 XRCC2 ABHD16B RECQL4

3.53e-0515410750121d08cc527aed9b3e11ff62bb9012916f5c56b
ToppCelldroplet-Heart-nan-3m-Endothelial-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 THBD USHBP1 TMEM132A FBXL2

3.87e-051571075d85a2f56ae313baa9738e81d2756ce1fe1ba50db
ToppCellChildren_(3_yrs)-Immune-enucleated_erythrocyte-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CHST8 JAK3 DEDD2 PCYT1B SPIN3

5.35e-0516810758f0c4dfad9f6fed9dcc31795abfe77758ceb46a1
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 SYNE1 NHSL1 TNFSF11 SEMA5B

5.50e-051691075987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCell3'-Child04-06-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK4 PHKA1 USHBP1 ALPK3 L3MBTL4

6.14e-05173107585083b9ce20351dd69aa2327ad087b848b4307ff
ToppCellmild_COVID-19_(asymptomatic)-gd_T|World / disease group, cell group and cell class (v2)

SYNE1 LAG3 NCR3 SPTBN4 KIR3DL2

6.14e-051731075b6615ff02f5017d7150b1e33b53f8c7a26081a0d
ToppCelldroplet-Kidney-nan-21m-Endothelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TLNRD1 THBD FBXL7 USHBP1 ICAM5

7.22e-051791075ba38177ffcf3a20f02afeeaaa91bc8eab8d1ac05
ToppCelldroplet-Kidney-nan-21m-Endothelial-kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TLNRD1 THBD FBXL7 USHBP1 ICAM5

7.22e-051791075d121351b4c3b91108e6c5753d18a44d676f38d4c
ToppCellfacs-Marrow-B-cells-18m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DRC7 SPTBN4 THBD SPRYD3 ALPK3

7.41e-0518010757368ab31c3273374ef260f0d710d4eea83cbc4a2
ToppCellcellseq2-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-NK|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KLHL28 TCF19 SYNE1 NCR3 SPIN3

7.81e-0518210758ccffcbae28c374fd4161fb0d4cf2c49fae557f6
ToppCellCOVID-19_Mild-gd_T|COVID-19_Mild / Disease condition and Cell class

SYNE1 LAG3 NCR3 TLN1 KIR3DL2

8.01e-051831075f593a89b0aa8fffdfa403769916facfd30358521
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 HSPG2 TCF19 FBXL7 SEMA5B

8.22e-051841075688428103e8b19f45f2f65d70a0f30c904c8411c
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CECR2 HAPLN2 NHSL1 FBXL7 MAML2

8.43e-051851075b5277190866d9eb5b85eceaa5ba116ea6e6f286b
ToppCell3'-Adult-Appendix-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SYNE1 THBD USHBP1 ALPK3 FBXL2

8.87e-05187107537d8ee5c8bd6324749e5a2adef1d0482c75da80c
ToppCell3'-Adult-Appendix-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SYNE1 THBD USHBP1 ALPK3 FBXL2

8.87e-051871075ec98d5e480b08854dfd0ba6b1dc6610455f90640
ToppCellCOPD-Lymphoid-NK|World / Disease state, Lineage and Cell class

SYNE1 GRK5 BCR NCR3 KIR3DL2

9.32e-051891075c0ac160fa7e68b92414fb1600abcac8ad1a42232
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CECR2 HAPLN2 NHSL1 FBXL7 MAML2

9.32e-051891075784ace2be87f2ecb19490f4974f63a559516e0eb
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE1 JAK3 FBXL7 MAML2 LARGE1

9.56e-0519010751121eb607a984c59fbffe7220837fc178745aa55
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE1 JAK3 FBXL7 MAML2 LARGE1

9.56e-051901075048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DOCK4 HLA-DRB5 THBD ALPK3 C5AR1

9.56e-0519010750a944da2aaaef9289b2a4ffe360b0338724fd59b
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CECR2 HAPLN2 NHSL1 FBXL7 MAML2

9.56e-05190107507f21386ea6eb23416a537d2250e3042efe93fb0
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CECR2 HAPLN2 NHSL1 FBXL7 MAML2

9.80e-0519110752b056cbe2e82e056e1f798974999378460eb1d16
ToppCellIPF-Lymphoid-NK|Lymphoid / Disease state, Lineage and Cell class

SYNE1 BCR NCR3 KIR3DL2 L3MBTL4

9.80e-051911075f2ddc0962007d7a4e78fbd916ebb62fc557d480a
ToppCellHealthy_Control-Lymphoid-T-CD8_T|Healthy_Control / Condition, Lineage, Cell class and cell subclass

SYNE1 LAG3 PGLYRP2 NCR3 JAK3

1.00e-04192107536b6ea21b0b1342f2dcac4dcaf359b6c772203f7
ToppCelldroplet-Pancreas-Exocrine-18m-Endothelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 HK1 TCF19 USHBP1 TMEM132A

1.00e-041921075a42aed9e563f5f4af029b8804c104f11ad227a8f
ToppCellCOPD-Lymphoid-NK|Lymphoid / Disease state, Lineage and Cell class

SYNE1 BCR NCR3 KIR3DL2 L3MBTL4

1.03e-0419310750020249fa71afb500af73700543bb6f349be6b10
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 HSPG2 NHSL1 THBD FBXL7

1.05e-041941075e55dc30e200c9f576804acb642175eb4fa9146b5
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 HSPG2 SYNE1 FBXL7 SEMA5B

1.05e-041941075a52c5906fce43c2f72cf7e463a3d15cde06431f6
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-gd_T|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

SYNE1 LAG3 BCR NCR3 KIR3DL2

1.11e-041961075aec2b11a6048048820271266fdc8b8d806da9993
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 HSPG2 HLA-DRB5 THBD FBXL7

1.11e-041961075023312af38f816a44b407e0daa32590d953caf99
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-gd_T-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SYNE1 LAG3 BCR NCR3 KIR3DL2

1.11e-041961075aa0dc04f94a575cd442ee473b75a4f54268e4105
ToppCellHealthy/Control-gd_T|Healthy/Control / Disease group and Cell class

SYNE1 LAG3 BCR NCR3 KIR3DL2

1.11e-041961075a6f9e55cd1cd7facadb3f508bded68023c997f3f
ToppCellControl-Lymphoid_T/NK-gd_T|Control / Disease group, lineage and cell class

SYNE1 LAG3 BCR NCR3 KIR3DL2

1.11e-04196107598b11aada6bc5d928ef618573dc912d4d74a1092
ToppCellHealthy/Control-gd_T|World / Disease group and Cell class

SYNE1 LAG3 BCR NCR3 KIR3DL2

1.11e-041961075b982c84552e7efbff2be861f0f569f40804f5d88
ToppCell5'-Airway_Nasal-Immune_Lymphocytic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LAG3 PGLYRP2 NCR3 JAK3 TNFSF11

1.13e-04197107540b752b019c95994323c7f65644a6ccf336d327e
ToppCell3'_v3-Lung-Myeloid_Mac-Intermediate_macrophages|Lung / Manually curated celltypes from each tissue

DOCK4 HLA-DRB5 TLNRD1 THBD C5AR1

1.13e-041971075bcb4dc17dae705bd84ea6a2842d6b107562baeb7
ToppCellsevere_influenza-NK|World / disease group, cell group and cell class (v2)

SYNE1 LAG3 NCR3 FUT11 KIR3DL2

1.13e-0419710758e86a1ee0418e153d4f0bf291006cffc6cf36f71
ToppCellControl-Control-Lymphocyte-T/NK-NK_activated|Control / Disease, condition lineage and cell class

SYNE1 PDZD7 ACOT4 PLCG1 MRFAP1L1

1.16e-04198107576d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 HSPG2 SYNE1 FBXL7 SEMA5B

1.16e-04198107531ba87552be97c9b78c9e82f98e96699ccb19824
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 HSPG2 SYNE1 NHSL1 FBXL7

1.16e-0419810751378c6d4ceb84b42fdd6556be3296df7a8059e6e
ToppCellHealthy_donor-gd_T|Healthy_donor / disease group, cell group and cell class (v2)

SYNE1 LAG3 BCR NCR3 KIR3DL2

1.16e-04198107525158815287efbdd8f463baa755cbb874f3905f3
ToppCellmild-Lymphocytic-NK_cells|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

SYNE1 NCR3 FUT11 TLN1 KIR3DL2

1.16e-0419810751d20fc9948965de52a98f758035edfdd12cafc5f
ToppCell10x5'v1-week_12-13-Endothelial-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 NHSL1 THBD USHBP1 ALPK3

1.16e-041981075122215d9288533ad03562cf777e846504863df9a
ToppCell10x5'v1-week_12-13-Endothelial|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 NHSL1 THBD USHBP1 ALPK3

1.16e-041981075307dd09e6bc820a148f3000f18dae7aedba4be0b
ToppCellIPF-Endothelial-VE_Peribronchial|Endothelial / Disease state, Lineage and Cell class

DOCK4 HSPG2 MYO1D TRIO ATP11C

1.16e-041981075b8bd1ba268480f54451648e01631b615a3401144
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

TCF19 SYNE1 LAG3 NCR3 KIR3DL2

1.16e-04198107580b105a7c7d00ea3b5e586831fbb755bd84f9d1a
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TCF19 SYNE1 LAG3 NCR3 KIR3DL2

1.16e-041981075c73e906d2d12d6eba0e606958be16e63a2292cd0
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

TCF19 SYNE1 LAG3 XRCC2 RECQL4

1.19e-041991075101f78fe6dd1bf9e2e4dd5ad8a970312b3540927
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TCF19 SYNE1 LAG3 XRCC2 RECQL4

1.19e-041991075e0fcec796afe75e42467ca86355b9fc5aa9ae0a1
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 HSPG2 SYNE1 HLA-DRB5 THBD

1.19e-04199107514e09eaa2335d4503de50250eb4258dd5b85b304
ToppCellControl-Control-Lymphocyte-T/NK-gd_T|Control / Disease, condition lineage and cell class

SYNE1 LAG3 BCR NCR3 KIR3DL2

1.22e-04200107588e502c141bbb73e62aa5830d24bd645376e5f3a
DiseaseCongenital Thrombotic Thrombocytopenic Purpura

ADAMTS13 THBD

7.07e-0541022C1268935
DiseaseFamilial Thrombotic Thrombocytopenic Purpura

ADAMTS13 THBD

7.07e-0541022C1956258
DiseasePurpura, Thrombotic Thrombocytopenic

ADAMTS13 THBD

7.07e-0541022C0034155
DiseaseThrombosis

ADAMTS13 THBD VKORC1

6.58e-04491023C0040053
Diseasecomplement C4 measurement

TCF19 HLA-DRB5 NCR3

7.84e-04521023EFO_0004984
DiseaseMUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2K

CRPPA LARGE1

1.05e-03141022C1836373
Diseasealpha-Dystroglycanopathies

CRPPA LARGE1

1.05e-03141022C2936406
DiseaseMuscle eye brain disease

CRPPA LARGE1

1.05e-03141022C0457133
DiseaseFukuyama Type Congenital Muscular Dystrophy

CRPPA LARGE1

1.05e-03141022C0410174
DiseaseMuscular Dystrophy-Dystroglycanopathy (Congenital with Brain and Eye Anomalies) Type A, 1

CRPPA LARGE1

1.05e-03141022C4284790
Diseaseresponse to carboplatin

STIM2 XRCC2 NHSL1

1.08e-03581023GO_0097328
DiseaseWalker-Warburg congenital muscular dystrophy

CRPPA LARGE1

1.21e-03151022C0265221
Diseaseselenium measurement, response to dietary selenium supplementation

TRIO ZC3H7A

2.16e-03201022EFO_0006331, EFO_0600021
Diseaseotosclerosis

TNFSF11 ALPK3 MAML2

2.81e-03811023EFO_0004213

Protein segments in the cluster

PeptideGeneStartEntry
HCEEAYRVLLALREA

USHBP1

351

Q8N6Y0
AHLRDIFLGRCAEYR

BST1

41

Q10588
YGCAADRAEEQRRHQ

BCR

436

P11274
RHTLQLYRCREEDAA

ALPK3

336

Q96L96
VHCYLSNLVRREEDG

AQR

281

O60306
CDIRLRVRAEYCEHG

DEDD2

196

Q8WXF8
ILEDSICYERRHRRG

DPY19L3

636

Q6ZPD9
VLCGVDYSHDKRRER

C5AR1

186

P21730
AVLHERYLARGCARR

DISP2

641

A7MBM2
ILHRLCDYRLDADDV

CECR2

116

Q9BXF3
RREHRAAGECLCYEG

ASTN1

481

O14525
VRRILYCARAHGEDD

ADAMTS13

971

Q76LX8
ERYHGRRAKLVACDG

ABHD16B

136

Q9H3Z7
RRELGCLDAYRRHDL

TFAP2D

131

Q7Z6R9
RIAHVELADAGQYRC

HSPG2

3541

P98160
QICRAHGIGYDVEER

IQCH

921

Q86VS3
YRGCRHEVVDGEARK

JAK3

536

P52333
DGCLDYSLERARHRA

CRPPA

196

A4D126
DIYHLSREGEAHERR

KIR3DL2

251

P43630
REDIASLIREHGRAY

MRFAP1L1

36

Q96HT8
EDGRLCLRVDHSRFE

CFAP99

71

D6REC4
HLENCRGLERLELYD

FBXL2

361

Q9UKC9
DLCYEFRRERFTVHR

LARGE1

441

O95461
EVCSAYLGLHDNDRR

LUC7L

191

Q9NQ29
FLEDRRAAVDTYCRH

HLA-DRB5

96

Q30154
RDVRGHDASIYVCRV

NCR3

96

O14931
AGVRLEDEGRYRCEL

HAPLN2

116

Q9GZV7
ATYRRLLEGEEHRLC

KRT85

421

P78386
TSHARCGDEVARYLD

PHKA1

651

P46020
VRGDHRADFYCAEVA

CCDC97

126

Q96F63
EARGLEDCRLDHALY

HSPB3

21

Q12988
VLRECDKLRHDGYRS

NHSL1

116

Q5SYE7
RLAACREHKRAPEVY

FAM86B1

231

Q8N7N1
LRHCRYVDEVIRDAP

PCYT1B

136

Q9Y5K3
RVAREHAGTYRCEAT

ICAM5

541

Q9UMF0
DLVCYRRRGHNEMDE

OGDHL

491

Q9ULD0
CSRYVHEGGIEDLVR

PDZD7

581

Q9H5P4
DYALLGHRQLVRTDC

PGLYRP2

516

Q96PD5
IRRGHDDLGDHYLDC

GPS1

161

Q13098
RRLCHEDVEALAAIY

DAPK3

346

O43293
DIVIRHRDVRSCHYG

MOSPD1

76

Q9UJG1
CYEVALADFRHGRAE

KIF1C

756

O43896
VAEVCGYRLRLHFDG

L3MBTL4

106

Q8NA19
EYRAAVHLRDRALSC

LAG3

146

P18627
GCLDDIRTHYDRLVD

HK1

716

P19367
REAGLYREALEHLCT

NAA15

201

Q9BXJ9
ARRYCHDLGERAGAL

MYBBP1A

886

Q9BQG0
YRERREKLHVCEDCG

OVOL3

181

O00110
HLSCEGRYERGRAES

MAML2

51

Q8IZL2
LIYESRGDRDLHCTE

HECTD1

2286

Q9ULT8
LSRDRSDCLGEHLYV

CLNS1A

66

P54105
RLYEANHLIRDDRTC

KLHL28

236

Q9NXS3
YDRVVLHGERCRSLL

DNASE1L1

226

P49184
RNKEFVCRGHDYERL

DOCK4

1331

Q8N1I0
THLYLRRCVRLTDEG

FBXL7

301

Q9UJT9
TYRDECELRAARCRG

FSTL3

141

O95633
SHCDVPADRDRYVRE

FUT11

216

Q495W5
IFRDQVVRYGCIRDH

CUL3

146

Q13618
RAACFDGHLEVVRYL

FEM1A

121

Q9BSK4
VAEERIQLRYHCRED

DRC7

611

Q8IY82
LGAEIARTCHESYDR

MAN1A2

486

O60476
DYEAVCGRRARLERE

DENND4B

551

O75064
LCGLEDLHRENTVYR

GRK5

296

P34947
CCGLEDLHRERIVYR

GRK6

296

P43250
EVCSAYLGLHDNDRR

LUC7L2

191

Q9Y383
DFLEFRRRVVCHYLE

PGBD3

511

Q8N328
QREEERYGAELEACR

ABCB8

351

Q9NUT2
CRRIEQHYFEDRGKG

MTX2

246

O75431
VSRRRYVHLCPREDE

FSCN2

146

O14926
RRGLAYVCHQRGEEL

QARS1

351

P47897
ETGYRLAADQHRCED

THBD

311

P07204
RLHECYGQEIRALRG

PHETA1

226

Q8N4B1
RYGEELREHAQCLEG

SYNE1

1531

Q8NF91
EAERRARGCHLQYQR

TMEM132A

531

Q24JP5
HVAEAEFDYARCGVR

TMEM151B

201

Q8IW70
YCRGDQLHILLEVRD

NXPE4

111

Q6UWF7
IRAAQDLCEEALRHY

PRPF6

691

O94906
AEAYHAGMCSRERRR

RECQL4

741

O94761
EETLQEACRHLGRYR

PNMA3

36

Q9UL41
DCVYGLELHRDERVL

SPIN2A

91

Q99865
FRAHARYCADARGEL

ACOT4

46

Q8N9L9
RYCADARGELDLERA

ACOT4

51

Q8N9L9
VSRIFVEDRHRVLYC

CHST8

181

Q9H2A9
AIKQGYEDCLRHRAD

ATP11C

106

Q8NB49
YRLGHRADLCDVALR

TCF19

31

Q9Y242
GRLHDVRVCGTLLEY

SPRYD3

221

Q8NCJ5
RADVYRDILACGRGD

TJP2

591

Q9UDY2
AARARDRDYRALCDV

VKORC1

31

Q9BQB6
YAKEEACRLRELREG

STIM2

296

Q9P246
DVRLRALHYGRECAN

TLN1

2231

Q9Y490
DCVYGLELHRDERVS

SPIN3

91

Q5JUX0
DCVYGLELHRDERVL

SPIN2B

91

Q9BPZ2
GRHIAERLLTEYCIE

PLCG1

561

P19174
GLVDRYRVTRCRHEV

TLNRD1

146

Q9H1K6
ARVGCHIGDLYVDLR

SPTBN4

76

Q9H254
LRENAVEHDCGRTVY

SEMA5B

301

Q9P283
VEHDCGRTVYSRVAR

SEMA5B

306

Q9P283
HASRRLCDVDIDYRP

XRCC2

211

O43543
EDGTHCIYRILRLHE

TNFSF11

81

O14788
RHEVRYGCLREDECF

ZC3H7A

636

Q8IWR0
LYERDCRRRFTPEDH

UBE3B

601

Q7Z3V4
EYHTRIRDACLRADR

SNX32

216

Q86XE0
LHGDCDDDKYRRRPA

ZFPL1

226

O95159
LGEVLEAVRYLHNCR

TRIO

2896

O75962
VCRHEVRYGCLREDS

ZC3H7B

616

Q9UGR2
FDDERCRHQVEYLGL

MYO1D

601

O94832
AEFLERRERECEHGY

MXI1

16

P50539
RYCRGHLARRLAEHL

MYO5B

796

Q9ULV0
EEGLQDFHRALRCYV

NECAB3

306

Q96P71