Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of cytoskeleton

ANK2 ANK3 SPTBN1 SPTBN2 ACTR2

5.62e-05130635GO:0005200
GeneOntologyBiologicalProcessregulation of postsynaptic neurotransmitter receptor internalization

USP6 VAC14 NEDD4L SCRIB

6.80e-0639654GO:0099149
GeneOntologyBiologicalProcessregulation of postsynaptic membrane neurotransmitter receptor levels

GPHN USP6 VAC14 NEDD4L IQSEC2 SCRIB

1.29e-05164656GO:0099072
GeneOntologyBiologicalProcesspostsynaptic endocytosis

USP6 VAC14 NEDD4L SCRIB

2.01e-0551654GO:0140239
GeneOntologyBiologicalProcesspostsynaptic neurotransmitter receptor internalization

USP6 VAC14 NEDD4L SCRIB

2.01e-0551654GO:0098884
GeneOntologyBiologicalProcessprotein-containing complex localization

GPHN USP6 VAC14 NEDD4L CEP112 IQSEC2 SCRIB

2.68e-05278657GO:0031503
GeneOntologyBiologicalProcessneurotransmitter receptor internalization

USP6 VAC14 NEDD4L SCRIB

3.35e-0558654GO:0099590
GeneOntologyBiologicalProcessestablishment or maintenance of epithelial cell apical/basal polarity

PARD6B DLG5 WNT11 SCRIB

3.35e-0558654GO:0045197
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

PARD6B DIP2A NEDD4L ANK3 VPS13A OSTN RTN4RL1 CORO1B WLS NYAP1 ACTR2

4.56e-058196511GO:0120039
GeneOntologyBiologicalProcessestablishment or maintenance of bipolar cell polarity

PARD6B DLG5 WNT11 SCRIB

4.65e-0563654GO:0061245
GeneOntologyBiologicalProcessestablishment or maintenance of apical/basal cell polarity

PARD6B DLG5 WNT11 SCRIB

4.65e-0563654GO:0035088
GeneOntologyBiologicalProcesscell projection morphogenesis

PARD6B DIP2A NEDD4L ANK3 VPS13A OSTN RTN4RL1 CORO1B WLS NYAP1 ACTR2

4.92e-058266511GO:0048858
GeneOntologyBiologicalProcessregulation of receptor-mediated endocytosis

USP6 VAC14 NEDD4L SYT11 SCRIB

1.33e-04156655GO:0048259
GeneOntologyBiologicalProcessprotein localization to adherens junction

DLG5 SCRIB

1.45e-046652GO:0071896
GeneOntologyBiologicalProcessneuron projection development

PARD6B DIP2A DLG5 ARID1B NEDD4L ANK3 VPS13A OSTN RTN4RL1 SCRIB WLS NYAP1 ACTR2

1.57e-0412856513GO:0031175
GeneOntologyBiologicalProcessestablishment or maintenance of cell polarity

PARD6B DLG5 ANK3 WNT11 SCRIB ACTR2

1.58e-04257656GO:0007163
GeneOntologyBiologicalProcesscell-cell junction assembly

PARD6B DLG5 NEDD4L ANK2 WNT11

1.83e-04167655GO:0007043
GeneOntologyBiologicalProcessneuron projection morphogenesis

PARD6B DIP2A NEDD4L ANK3 VPS13A OSTN RTN4RL1 WLS NYAP1 ACTR2

1.93e-048026510GO:0048812
GeneOntologyBiologicalProcesscell junction organization

GPHN PARD6B DIP2A DLG5 NEDD4L ANK2 ANK3 IQSEC2 SPTBN2 WNT11 ACTR2

2.12e-049746511GO:0034330
GeneOntologyBiologicalProcessregulation of endocytosis

USP6 VAC14 NEDD4L ANK3 SYT11 PTX3 SCRIB

2.18e-04389657GO:0030100
GeneOntologyBiologicalProcessregulation of receptor internalization

USP6 VAC14 NEDD4L SCRIB

2.31e-0495654GO:0002090
GeneOntologyBiologicalProcessendocytosis

USP6 VAC14 OCIAD1 NEDD4L ANK2 ANK3 SYT11 PTX3 SCRIB LILRB4

2.46e-048276510GO:0006897
GeneOntologyBiologicalProcessreceptor internalization

USP6 VAC14 NEDD4L SCRIB LILRB4

2.72e-04182655GO:0031623
GeneOntologyBiologicalProcessreceptor localization to synapse

GPHN CEP112 IQSEC2 SCRIB

2.92e-04101654GO:0097120
GeneOntologyBiologicalProcesscell morphogenesis

PARD6B DIP2A NEDD4L ANK3 VPS13A OSTN RTN4RL1 CORO1B SCRIB WLS NYAP1 ACTR2

3.11e-0411946512GO:0000902
GeneOntologyBiologicalProcessnegative regulation of keratinocyte differentiation

MSX2 EXTL3

4.33e-0410652GO:0045617
GeneOntologyBiologicalProcessbiomineral tissue development

MSX2 WNT11 OSTN SLC24A3 WLS

4.50e-04203655GO:0031214
GeneOntologyBiologicalProcessvesicle-mediated transport in synapse

USP6 VAC14 NEDD4L SYT11 SPTBN2 SCRIB

5.18e-04321656GO:0099003
GeneOntologyBiologicalProcesspost-Golgi vesicle-mediated transport

ANK3 SPTBN1 VPS13A ARFGEF2

5.44e-04119654GO:0006892
GeneOntologyBiologicalProcessneuron development

PARD6B DIP2A DLG5 ARID1B NEDD4L ANK3 VPS13A OSTN RTN4RL1 SCRIB WLS NYAP1 ACTR2

5.55e-0414636513GO:0048666
GeneOntologyBiologicalProcessmembrane depolarization

NEDD4L ANK2 ANK3 KMT2A

5.79e-04121654GO:0051899
GeneOntologyBiologicalProcessdendrite development

DIP2A DLG5 ARID1B NEDD4L WLS ACTR2

6.48e-04335656GO:0016358
GeneOntologyBiologicalProcessreceptor-mediated endocytosis

USP6 VAC14 NEDD4L SYT11 SCRIB LILRB4

6.68e-04337656GO:0006898
GeneOntologyBiologicalProcesspositive regulation of cation channel activity

NEDD4L ANK2 ANK3

7.35e-0456653GO:2001259
GeneOntologyCellularComponentasymmetric synapse

GPHN USP6 DLG5 ANK2 ANK3 SYT11 SPTBN1 IQSEC2 ARFGEF2 SCRIB

2.34e-064776610GO:0032279
GeneOntologyCellularComponentspectrin-associated cytoskeleton

ANK3 SPTBN1 SPTBN2

2.49e-069663GO:0014731
GeneOntologyCellularComponentneuron to neuron synapse

GPHN USP6 DLG5 ANK2 ANK3 SYT11 SPTBN1 IQSEC2 ARFGEF2 SCRIB

5.29e-065236610GO:0098984
GeneOntologyCellularComponentpostsynaptic density

GPHN USP6 DLG5 ANK2 ANK3 SYT11 SPTBN1 IQSEC2 SCRIB

1.16e-05451669GO:0014069
GeneOntologyCellularComponentpostsynapse

GPHN USP6 DIP2A DLG5 ANK2 ANK3 SYT11 SPTBN1 IQSEC2 SPTBN2 ARFGEF2 SCRIB ACTR2

1.48e-0510186613GO:0098794
GeneOntologyCellularComponentpostsynaptic specialization

GPHN USP6 DLG5 ANK2 ANK3 SYT11 SPTBN1 IQSEC2 SCRIB

2.76e-05503669GO:0099572
GeneOntologyCellularComponentinhibitory synapse

GPHN SYT11 CEP112

1.27e-0431663GO:0060077
GeneOntologyCellularComponentglutamatergic synapse

USP6 DIP2A DLG5 NEDD4L SPTBN1 IQSEC2 SPTBN2 ARFGEF2 CORO1B SCRIB

2.28e-048176610GO:0098978
GeneOntologyCellularComponentspectrin

SPTBN1 SPTBN2

3.48e-049662GO:0008091
GeneOntologyCellularComponentparanodal junction

ANK2 SPTBN2

5.30e-0411662GO:0033010
GeneOntologyCellularComponentpostsynaptic specialization, intracellular component

GPHN USP6 IQSEC2

7.39e-0456663GO:0099091
HumanPhenoShort nose

DPYD ARID1B NEDD4L TMEM94 SPTBN1 IQSEC2 KMT2A EXTL3 EDA

8.72e-06325249HP:0003196
HumanPhenoHypoplasia of the phalanges of the toes

VAC14 ARID1B WLS

1.97e-0512243HP:0010746
HumanPhenoAplasia/Hypoplasia involving the nose

DPYD ARID1B NEDD4L TMEM94 SPTBN1 IQSEC2 KMT2A EXTL3 EDA

4.77e-05401249HP:0009924
HumanPhenoAbnormal morphology of the nasal alae

DPYD VAC14 ARID1B NEDD4L TMEM94 SPTBN1 IQSEC2 KMT2A EXTL3 WLS EDA

5.92e-056392411HP:0000429
HumanPhenoAnteverted nares

DPYD VAC14 ARID1B NEDD4L TMEM94 SPTBN1 IQSEC2 KMT2A EXTL3 WLS

1.10e-045592410HP:0000463
HumanPhenoUpturned nose

DPYD VAC14 ARID1B NEDD4L TMEM94 SPTBN1 IQSEC2 KMT2A EXTL3 WLS

1.10e-045592410HP:0000427
HumanPhenoSacral dimple

FANCB ARID1B KMT2A EXTL3 WLS

1.31e-04110245HP:0000960
HumanPhenoAbnormal nostril morphology

DPYD VAC14 ARID1B NEDD4L TMEM94 SPTBN1 IQSEC2 KMT2A EXTL3 WLS

1.39e-045752410HP:0005288
HumanPhenoSacrococcygeal pilonidal abnormality

FANCB ARID1B KMT2A EXTL3 WLS

1.56e-04114245HP:0010767
HumanPhenoSkin dimple

FANCB ARID1B KMT2A EXTL3 WLS

1.98e-04120245HP:0010781
HumanPhenoAbnormal finger phalanx morphology

MSX2 FANCB VAC14 ARID1B NEDD4L SPTBN1 IQSEC2 KMT2A EXTL3 WLS EDA

2.25e-047382411HP:0005918
HumanPhenoShort chin

VAC14 ARID1B EXTL3 EDA

2.67e-0469244HP:0000331
HumanPhenoImpaired social interactions

GPHN SPTBN1 IQSEC2 ARFGEF2 EXTL3

2.78e-04129245HP:0000735
HumanPhenoAbnormal social development

GPHN DPYD WDR45 ARID1B ANK3 SPTBN1 IQSEC2 VPS13A ARFGEF2 KMT2A EXTL3 WLS

3.15e-049082412HP:0025732
HumanPhenoNo social interaction

IQSEC2 EXTL3

3.15e-046242HP:0008763
HumanPhenoShort phalanx of finger

MSX2 VAC14 ARID1B KMT2A EXTL3 WLS EDA

3.75e-04306247HP:0009803
DomainSpectrin_bsu

SPTBN1 SPTBN2

7.80e-054682IPR016343
DomainZU5

ANK2 ANK3

4.63e-049682SM00218
DomainPH_dom-spectrin-type

SPTBN1 SPTBN2

4.63e-049682IPR001605
DomainZU5

ANK2 ANK3

5.77e-0410682PS51145
DomainZU5

ANK2 ANK3

8.42e-0412682PF00791
DomainZU5_dom

ANK2 ANK3

8.42e-0412682IPR000906
Domain-

IQSEC2 ARFGEF2

1.33e-03156821.10.1000.11
DomainSec7

IQSEC2 ARFGEF2

1.33e-0315682PF01369
DomainSec7_alpha_orthog

IQSEC2 ARFGEF2

1.33e-0315682IPR023394
DomainSec7

IQSEC2 ARFGEF2

1.52e-0316682SM00222
DomainSEC7

IQSEC2 ARFGEF2

1.52e-0316682PS50190
DomainSec7_dom

IQSEC2 ARFGEF2

1.52e-0316682IPR000904
DomainActinin_actin-bd_CS

SPTBN1 SPTBN2

3.15e-0323682IPR001589
DomainSpectrin

SPTBN1 SPTBN2

3.15e-0323682PF00435
DomainACTININ_2

SPTBN1 SPTBN2

3.15e-0323682PS00020
DomainACTININ_1

SPTBN1 SPTBN2

3.15e-0323682PS00019
DomainLRR_8

LRRC66 LRRC37A3 RTN4RL1 SCRIB

3.50e-03171684PF13855
DomainLeu-rich_rpt_typical-subtyp

LRRC66 LRRC37A3 RTN4RL1 SCRIB

3.96e-03177684IPR003591
DomainLRR_TYP

LRRC66 LRRC37A3 RTN4RL1 SCRIB

3.96e-03177684SM00369
DomainDEATH

ANK2 ANK3

4.32e-0327682SM00005
Domain-

DLG5 ANK2 ANK3

4.74e-03936831.10.533.10
DomainSpectrin_repeat

SPTBN1 SPTBN2

4.98e-0329682IPR002017
DomainDEATH-like_dom

DLG5 ANK2 ANK3

5.64e-0399683IPR011029
DomainSpectrin/alpha-actinin

SPTBN1 SPTBN2

6.04e-0332682IPR018159
DomainSPEC

SPTBN1 SPTBN2

6.04e-0332682SM00150
DomainLRR

LRRC66 LRRC37A3 RTN4RL1 SCRIB

6.20e-03201684PS51450
DomainDeath

ANK2 ANK3

6.41e-0333682PF00531
DomainLRR_1

LRRC66 LRRC37A3 RTN4RL1 SCRIB

8.34e-03219684PF00560
DomainDeath_domain

ANK2 ANK3

8.44e-0338682IPR000488
DomainDEATH_DOMAIN

ANK2 ANK3

8.44e-0338682PS50017
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

ANK2 ANK3 SPTBN1 SPTBN2

2.93e-0631464M877
PathwayREACTOME_RHOV_GTPASE_CYCLE

PARD6B DLG5 SPTBN1

2.34e-0437463M41819
PathwayREACTOME_RHOV_GTPASE_CYCLE

PARD6B DLG5 SPTBN1

2.34e-0437463MM15610
PathwayREACTOME_COPI_MEDIATED_ANTEROGRADE_TRANSPORT

ANK2 ANK3 SPTBN1 SPTBN2

3.34e-04102464M27648
PathwayREACTOME_RND1_GTPASE_CYCLE

DLG5 FRS3 FAM135A

3.41e-0442463M41828
PathwayREACTOME_RND2_GTPASE_CYCLE

DLG5 FRS3 SCRIB

3.66e-0443463M41827
PathwayREACTOME_RND1_GTPASE_CYCLE

DLG5 FRS3 FAM135A

3.66e-0443463MM15679
PathwayREACTOME_RND2_GTPASE_CYCLE

DLG5 FRS3 SCRIB

3.92e-0444463MM15678
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SPTBN1 SPTBN2

4.61e-0410462MM15112
PathwayREACTOME_L1CAM_INTERACTIONS

ANK2 ANK3 SPTBN1 SPTBN2

6.38e-04121464M872
Pubmed

Cell organization, growth, and neural and cardiac development require αII-spectrin.

ANK2 ANK3 SPTBN1 SPTBN2

2.78e-091068422159418
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

GPHN DIP2A ASRGL1 NEDD4L ANK2 ANK3 SPTBN1 IQSEC2 SPTBN2 ARFGEF2 KMT2A CORO1B SCRIB ACTR2 TMEM33

8.68e-081431681537142655
Pubmed

In vivo assembly of the axon initial segment in motor neurons.

ANK2 ANK3 SPTBN2

1.42e-07668323728480
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

GPHN ARID1B ANK3 SPTBN2 MDC1 KMT2A CORO1B SCRIB TMEM33

1.23e-0654968938280479
Pubmed

Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth.

ANK2 ANK3 SPTBN2

3.20e-061568330562487
Pubmed

The small oligomerization domain of gephyrin converts MLL to an oncogene.

GPHN KMT2A

3.77e-06268214751928
Pubmed

Identification of risk genes for autism spectrum disorder through copy number variation analysis in Austrian families.

GPHN DIP2A

3.77e-06268224643514
Pubmed

Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells.

ANK3 SPTBN1

3.77e-06268217074766
Pubmed

The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes.

ANK2 ANK3

3.77e-06268211781319
Pubmed

βII-spectrin promotes mouse brain connectivity through stabilizing axonal plasma membranes and enabling axonal organelle transport.

ANK2 SPTBN1

3.77e-06268231209033
Pubmed

Structural basis of diverse membrane target recognitions by ankyrins.

ANK2 ANK3

3.77e-06268225383926
Pubmed

Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia.

ANK2 SPTBN1

3.77e-06268225632041
Pubmed

Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes.

ANK2 SPTBN1

3.77e-06268215262991
Pubmed

Caspase-3/7-mediated Cleavage of β2-spectrin is Required for Acetaminophen-induced Liver Damage.

SPTBN1 SPTBN2

3.77e-06268226884715
Pubmed

Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.

GPHN ANK2 ANK3

5.71e-061868337321992
Pubmed

Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain.

GPHN ANK2 ANK3

5.71e-061868331910261
Pubmed

Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos.

ANK3 SPTBN1

1.13e-05368217620337
Pubmed

The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells.

ANK2 ANK3

1.13e-05368215611082
Pubmed

Human ankyrins and their contribution to disease biology: An update.

ANK2 ANK3

1.13e-05368233410423
Pubmed

Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling.

WNT11 WLS

1.13e-05368226845523
Pubmed

Ankyrin-dependent Na+ channel clustering prevents neuromuscular synapse fatigue.

ANK2 ANK3

1.13e-05368234289389
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

USP6 DIP2A WDR45 VAC14 OCIAD1 LRRC37A3 SPTBN1 IQSEC2 SPTBN2 TMCC1

1.21e-05925681028986522
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

GPHN ASRGL1 NEDD4L ANK2 ANK3 SYT11 SPTBN1 IQSEC2 CORO1B TMCC1 TMEM33

1.23e-051139681136417873
Pubmed

Endodermal Wnt signaling is required for tracheal cartilage formation.

MSX2 WNT11 WLS

1.23e-052368326093309
Pubmed

Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization.

GPHN ASRGL1 ANK2 ANK3 SPTBN1 SPTBN2 ACTR2

1.41e-0540368730562941
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

GPHN WDR45 NEDD4L ANK2 ANK3 SPTBN1 IQSEC2 SPTBN2 CORO1B SCRIB

1.72e-05963681028671696
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

GPHN ANK2 ANK3 SPTBN1 IQSEC2 SPTBN2

1.90e-0528168628706196
Pubmed

Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs.

SPTBN1 SPTBN2

2.25e-05468221412925
Pubmed

Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A.

ANK2 SPTBN1

2.25e-05468234812142
Pubmed

Ankyrin-B interactions with spectrin and dynactin-4 are required for dystrophin-based protection of skeletal muscle from exercise injury.

ANK2 SPTBN1

2.25e-05468221186323
Pubmed

Loss of β2-spectrin prevents cardiomyocyte differentiation and heart development.

SPTBN1 SPTBN2

2.25e-05468224064296
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

DIP2A DLG5 OCIAD1 ANK2 ANK3 SPTBN1 SPTBN2 VPS13A SCRIB FAM135A TMCC1 TMEM33

2.82e-051487681233957083
Pubmed

CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.

ANK2 ANK3

3.75e-05568225950943
Pubmed

Glial ankyrins facilitate paranodal axoglial junction assembly.

ANK2 ANK3

3.75e-05568225362471
Pubmed

TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis.

MSX2 EDA

3.75e-05568211203701
Pubmed

A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly.

ANK2 SPTBN1

3.75e-05568222632975
Pubmed

TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.

SPTBN1 SPTBN2

3.75e-05568226784546
Pubmed

T-type calcium channels functionally interact with spectrin (α/β) and ankyrin B.

ANK2 SPTBN1

3.75e-05568229720258
Pubmed

An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan.

ANK2 ANK3

3.75e-05568219109891
Pubmed

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.

ANK2 ANK3 SPTBN1 IQSEC2 FRS3

4.32e-0519768536604605
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

GPHN DLG5 NEDD4L CEP112 SPTBN1 IQSEC2 KMT2A SCRIB TMCC1

4.47e-0586168936931259
Pubmed

α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.

ANK3 SPTBN1 SCRIB

4.47e-053568337381005
Pubmed

Dual regulation of planar polarization by secreted Wnts and Vangl2 in the developing mouse cochlea.

PARD6B WNT11 WLS

4.47e-053568332907846
Pubmed

A human MAP kinase interactome.

PARD6B NEDD4L ANK3 SPTBN1 SPTBN2 CCDC92 EXTL3

4.63e-0548668720936779
Pubmed

Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.

GPHN ANK2 SCRIB

5.30e-053768327565344
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

DLG5 LRRC37A3 IQSEC2 EXTL3

5.51e-051056849628581
Pubmed

ELF a beta-spectrin is a neuronal precursor cell marker in developing mammalian brain; structure and organization of the elf/beta-G spectrin gene.

ANK2 SPTBN1

5.62e-05668212149647
Pubmed

Analysis of erythrocyte and platelet membrane proteins in various forms of beta-thalassemia.

ANK2 SPTBN1

5.62e-05668215310273
Pubmed

ST3GAL1 and βII-spectrin pathways control CAR T cell migration to target tumors.

SPTBN1 SPTBN2

5.62e-05668237069398
Pubmed

Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton.

ANK2 SPTBN2

5.62e-05668216687515
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

GPHN WDR45 VAC14 OCIAD1 VPS13A ARFGEF2 FAM135A

5.82e-0550468734432599
Pubmed

Distinct requirements for cranial ectoderm and mesenchyme-derived wnts in specification and differentiation of osteoblast and dermal progenitors.

MSX2 WNT11 WLS

6.21e-053968324586192
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

VAC14 SYT11 TMEM94 SPTBN2 MDC1 SCRIB WLS TMEM33

6.41e-0569768828298427
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

DLG5 ANK2 ANK3 SPTBN1 CORO1B SCRIB FAM135A TMEM33

7.15e-0570868839231216
Pubmed

Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

DIP2A TMEM94 MDC1

7.23e-05416838724849
Pubmed

Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice.

ANK2 ANK3

7.86e-0576827495297
Pubmed

Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner.

ANK2 ANK3 SPTBN1 SPTBN2 ACTR2

9.56e-0523368529518331
Pubmed

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.

DIP2A ANK3 SYT11 SPTBN1 SCRIB WLS

9.69e-0537768638117590
Pubmed

Polarity protein complex Scribble/Lgl/Dlg and epithelial cell barriers.

DLG5 SCRIB

1.05e-04868223397623
Pubmed

Msx genes delineate a novel molecular map of the developing cerebellar neuroepithelium.

MSX2 WLS

1.05e-04868238742226
Pubmed

Isoform diversity in the Arp2/3 complex determines actin filament dynamics.

CORO1B ACTR2

1.05e-04868226655834
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

ANK2 TMEM94 SPTBN2 ARFGEF2 SCRIB WLS FAM135A

1.24e-0456968730639242
Pubmed

Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.

DLG5 SCRIB

1.34e-04968228169360
Pubmed

Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins.

ANK2 ANK3

1.34e-04968229867141
Pubmed

Polarity inversion reorganizes the stem cell compartment of the trophoblast lineage.

PARD6B SCRIB

1.34e-04968236989113
Pubmed

TBR1 regulates autism risk genes in the developing neocortex.

ARID1B ANK2

1.34e-04968227325115
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

ANK2 ANK3 SPTBN1 IQSEC2 SPTBN2

1.35e-0425168527507650
Pubmed

Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.

ARID1B KMT2A

1.68e-041068212665591
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

PARD6B NEDD4L ANK3 TMEM94 SCRIB FAM135A

1.76e-0442168636976175
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

THAP4 DIP2A ANK2 ANK3 SPTBN1 IQSEC2 SPTBN2 ARFGEF2 SCRIB EXTL3

1.90e-041285681035914814
Pubmed

Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.

SPTBN1 SPTBN2

2.05e-041168217607528
Pubmed

Deciphering epiblast lumenogenesis reveals proamniotic cavity control of embryo growth and patterning.

PARD6B SCRIB

2.05e-041168233692105
Pubmed

Wnt-mediated reciprocal regulation between cartilage and bone development during endochondral ossification.

WNT11 WLS

2.05e-041168223274346
Pubmed

Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause.

PARD6B WLS

2.05e-041168233127892
Pubmed

Cardiac progenitors instruct second heart field fate through Wnts.

WNT11 WLS

2.45e-041268236649430
Pubmed

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.

DPYD ANK3 KMT2A

2.86e-046568323453885
Pubmed

FGFR2 is associated with hair thickness in Asian populations.

MSX2 EDA

2.90e-041368219590514
Pubmed

alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.

SPTBN1 SPTBN2

2.90e-041368218796539
Pubmed

Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis.

MSX2 EDA

3.38e-041468218022614
Pubmed

FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis.

FANCB MDC1

3.38e-041468226123487
Pubmed

Role of Foxl2 in uterine maturation and function.

MSX2 WNT11

3.38e-041468225687138
Pubmed

Rac1 signaling is critical to cardiomyocyte polarity and embryonic heart development.

SCRIB ACTR2

3.38e-041468225315346
Pubmed

Wnt/β-catenin signaling in the mouse embryonic cranial mesenchyme is required to sustain the emerging differentiated meningeal layers.

MSX2 WLS

3.38e-041468230615824
Pubmed

Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells.

PARD6B SPTBN2

3.38e-041468228266911
Pubmed

Scribble mutation disrupts convergent extension and apical constriction during mammalian neural tube closure.

PARD6B SCRIB

3.89e-041568234029538
Pubmed

Dlx5 and Dlx6 control uterine adenogenesis during post-natal maturation: possible consequences for endometriosis.

MSX2 WNT11

3.89e-041568226512061
Pubmed

Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects.

WNT11 SCRIB

3.89e-041568226883626
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

DIP2A DPYD ANK3 SPTBN1 SPTBN2 KMT2A

4.28e-0449768636774506
Pubmed

Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction.

WNT11 EDA

4.44e-041668219619491
Pubmed

Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state.

WNT11 SCRIB

4.44e-041668218177851
Pubmed

Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2.

WNT11 SCRIB

4.44e-041668217767158
Pubmed

Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers.

ANK2 SPTBN1

4.44e-041668221745462
Pubmed

Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.

FANCB MDC1

4.44e-041668227760317
Pubmed

Combinatorial CRISPR screen identifies fitness effects of gene paralogues.

ARID1B ASRGL1 ARFGEF2 KMT2A

4.94e-0418668433637726
Pubmed

Wnt signaling in the murine diastema.

MSX2 WNT11

5.03e-041768221531785
Pubmed

Mesenchymal Wnt signaling promotes formation of sternum and thoracic body wall.

WNT11 WLS

5.03e-041768225727890
Pubmed

Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN.

SPTBN1 SPTBN2 CCDC92 CORO1B TMEM33

5.04e-0433468530425250
Pubmed

Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract.

MSX2 WNT11

5.65e-041868216839542
Pubmed

Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.

SPTBN1 SPTBN2

5.65e-041868212119179
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

FAM47A DIP2A IQSEC2 SPTBN2 VPS13A ZC2HC1C SCRIB

5.85e-0473668729676528
InteractionRHOB interactions

DIP2A DLG5 NEDD4L ANK3 MRPL16 RRP36 SPTBN1 IQSEC2 SPTBN2 VPS13A SCRIB WLS FAM135A

2.30e-068406513int:RHOB
InteractionRND3 interactions

PARD6B DLG5 ANK3 MRPL16 SPTBN1 SPTBN2 SCRIB FAM135A

2.65e-06273658int:RND3
InteractionRHOJ interactions

PARD6B DIP2A DLG5 NEDD4L MRPL16 SPTBN1 SPTBN2 VPS13A ARFGEF2 SCRIB FAM135A

5.16e-066336511int:RHOJ
InteractionRHOF interactions

PARD6B DLG5 WDR45 ANK3 MRPL16 SPTBN1 SPTBN2 VPS13A ARFGEF2 SCRIB FAM135A

9.20e-066736511int:RHOF
InteractionRAB35 interactions

DLG5 OCIAD1 ANK3 SPTBN1 SPTBN2 VPS13A ARFGEF2 SCRIB WLS FAM135A

1.40e-055736510int:RAB35
InteractionKCNA3 interactions

DLG5 NEDD4L ANK2 ANK3 CEP112 SPTBN1 VPS13A KMT2A CORO1B SCRIB FAM135A TMEM33

1.92e-058716512int:KCNA3
InteractionKCTD13 interactions

GPHN DIP2A ASRGL1 NEDD4L ANK2 ANK3 SPTBN1 IQSEC2 SPTBN2 ARFGEF2 KMT2A CORO1B SCRIB ACTR2 TMEM33

2.84e-0513946515int:KCTD13
InteractionSHANK3 interactions

NEDD4L ANK2 ANK3 SPTBN1 IQSEC2 SPTBN2 FRS3 ACTR2 TMEM33

2.90e-05496659int:SHANK3
InteractionRHOU interactions

DLG5 NEDD4L ANK3 MRPL16 SYT11 SPTBN1 SPTBN2 SCRIB FAM135A

3.60e-05510659int:RHOU
InteractionANK3 interactions

GPHN DLG5 ANK2 ANK3 SPTBN1 SPTBN2

4.63e-05201656int:ANK3
InteractionAGAP2 interactions

GPHN ANK2 ANK3 SPTBN1 IQSEC2 SPTBN2

5.90e-05210656int:AGAP2
InteractionC11orf52 interactions

DIP2A DLG5 ANK3 SPTBN1 SPTBN2 SCRIB FAM135A

6.30e-05311657int:C11orf52
InteractionMAP1LC3B interactions

GPHN WDR45 ANK2 ANK3 CEP112 MDC1 CORO1B ACTR2 TMEM33

6.54e-05551659int:MAP1LC3B
InteractionRHOQ interactions

PARD6B DLG5 VAC14 SPTBN1 SPTBN2 VPS13A SCRIB FAM135A

8.49e-05442658int:RHOQ
InteractionZFPL1 interactions

DLG5 OCIAD1 ANK3 SPTBN1 SPTBN2 ARFGEF2 SCRIB FAM135A

9.32e-05448658int:ZFPL1
InteractionTHBS3 interactions

FANCB DIP2A IQSEC2 MCM9

9.57e-0574654int:THBS3
InteractionFLOT1 interactions

DLG5 OCIAD1 ANK2 ANK3 SPTBN1 SPTBN2 SCRIB FAM135A

1.40e-04475658int:FLOT1
InteractionRND1 interactions

DLG5 SPTBN1 SPTBN2 FRS3 SCRIB FAM135A

1.41e-04246656int:RND1
InteractionRAC3 interactions

PARD6B DIP2A DLG5 MRPL16 SPTBN1 SPTBN2 VPS13A SCRIB FAM135A

1.58e-04619659int:RAC3
InteractionCHRNA4 interactions

CSGALNACT2 ERMP1 EXTL3 WLS EDA

1.62e-04159655int:CHRNA4
InteractionOCLN interactions

DLG5 NEDD4L ANK2 ANK3 SPTBN1 SPTBN2 SCRIB FAM135A

1.98e-04500658int:OCLN
InteractionDIRAS3 interactions

DLG5 ANK3 SPTBN1 SPTBN2 SCRIB FAM135A

1.98e-04262656int:DIRAS3
InteractionDNAJC5 interactions

DLG5 ANK3 SPTBN1 SPTBN2 SCRIB FAM135A TMEM33

2.11e-04378657int:DNAJC5
InteractionTNIK interactions

NEDD4L ANK2 ANK3 SPTBN1 IQSEC2 SPTBN2 CCDC92

2.22e-04381657int:TNIK
InteractionYWHAZ interactions

PARD6B MSX2 DLG5 NEDD4L CEP112 SPTBN1 IQSEC2 SPTBN2 MDC1 KMT2A SCRIB TMCC1 ACTR2

2.56e-0413196513int:YWHAZ
InteractionKALRN interactions

ANK2 SPTBN1 IQSEC2 SPTBN2

2.62e-0496654int:KALRN
Cytoband17q24.1

LRRC37A3 CEP112

6.02e-05868217q24.1
Cytoband8p21

EXTL3 C8orf58

4.04e-04206828p21
CytobandEnsembl 112 genes in cytogenetic band chr6p21

RRP36 MDC1 FRS3 ZBTB9 DNAH8

9.15e-04503685chr6p21
Cytoband20q13.13

PARD6B ARFGEF2

1.04e-033268220q13.13
CytobandEnsembl 112 genes in cytogenetic band chr8p21

TRIM35 EXTL3 C8orf58

1.08e-03135683chr8p21
GeneFamilyEF-hand domain containing|Spectrins

SPTBN1 SPTBN2

9.46e-0573921113
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

GPHN DPYD ARID1B NEDD4L ANK3 LRRC37A3 SLC24A3 TMCC1

6.64e-10196688ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

GPHN DPYD ARID1B NEDD4L ANK3 LRRC37A3 TMCC1

2.22e-081986871996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellmild-low-quality_cells|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LRRC66 DIP2A DLG5 ARID1B ANK3 VPS13A

5.70e-07197686e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCellnormal_Pleural_Fluid-T/NK_cells-CD4+_Th|T/NK_cells / Location, Cell class and cell subclass

ANK2 IQSEC2 RTN4RL1 CORO1B FAM135A

5.24e-06164685334f376350c9cf92611d0f75b2e18a102f4c116a
ToppCellE15.5-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PARD6B WDR45 NEDD4L ANK3 WLS

1.10e-05191685402c341b00f98e8215458766b3c219fff8dcb447
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GPHN PARD6B NEDD4L ANK3 FAM135A

1.18e-051946857002937e8903e037332a215d00fbc7c7843b33f2
ToppCellfacs-Brain_Non-Myeloid-Cortex|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIP2A ASRGL1 ANK2 SYT11 ERMP1

1.24e-05196685256fe9bc0815f66a9afe11ba3507ef1372b52fd3
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIP2A ASRGL1 ANK2 SYT11 ERMP1

1.31e-05198685a7e5de81eb7d3d23812c179a001adbaab1506596
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIP2A ASRGL1 ANK2 SYT11 ERMP1

1.31e-05198685731a90f7e68b19e387499d63e3979af78b503b0c
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIP2A ASRGL1 ANK2 SYT11 ERMP1

1.31e-0519868543a2ce64fa309bac89a44ea320e87ae2cc39f782
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

GPHN DPYD ARID1B ANK3 LRRC37A3

1.34e-0519968594b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate|5w / Sample Type, Dataset, Time_group, and Cell type.

DLG5 NEDD4L ANK3 SPTBN1 KMT2A

1.37e-05200685c92e4fc0442404481fcac623d691dae6215b852d
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Papillary_Renal_Cell_Carcinoma-4|TCGA-Kidney / Sample_Type by Project: Shred V9

ADGRG7 RRP36 FRS3 DNAH8

5.76e-05137684758aa466a01265ed67b94f1578b4099956506271
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FANCB WNT11 SLC24A3 CORO1B

9.77e-051576844766f7d545bf2d775390589460677519cb92f4d5
ToppCellnormal_Pleural_Fluid-T/NK_cells-CD4+_Th|normal_Pleural_Fluid / Location, Cell class and cell subclass

DIP2A ANK2 RTN4RL1 CORO1B

1.03e-04159684ebd840ac2b07e62086ee7b5bb01c21804a0fdc7b
ToppCelldroplet-Lung-nan-3m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PARD6B GARIN1A NEDD4L WNT11

1.16e-0416468478de403446fe0eb375c82ff1832cc5fbb8e20afa
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

GPHN RRP36 WLS FAM135A

1.21e-04166684f4698fd08965936d51695d571bd10fb77330d916
ToppCell3'-Adult-LargeIntestine-Epithelial-goblet-Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRRC66 GARIN1A NEDD4L ZBTB9

1.27e-041686842163e6774eb7a3d010422e4d59be5e45b4158329
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ARID1B NEDD4L SPTBN2 OSTN

1.33e-04170684928e42c51a7079c506f21c669c4e4c1a0df84d77
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

PARD6B NEDD4L ANK3 SLC24A3

1.42e-04173684b799c06a6a5754668e789f70c0c8bc1508568575
ToppCell356C-Myeloid-Dendritic-cDC_proliferating_2|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

ANK3 RRP36 CEP112 EDA

1.48e-041756847de1023161233b64f11e130881c742f4cf2bff65
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PARD6B NEDD4L ANK3 FAM135A

1.69e-04181684576da14ab3107f89e1f44a4a439d1bef5bb42370
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PARD6B ANK3 SLC24A3 FAM135A

1.87e-04186684acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCellE17.5-Epithelial-alveolar_epithelial_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PARD6B WDR45 NEDD4L WLS

1.87e-04186684a7a2ef8392a045a62fa4d0983577711d5d397dc4
ToppCellE17.5-Epithelial|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

WDR45 NEDD4L ANK3 WLS

1.91e-04187684fdabe716ce67f2eede90548198cbe20bbf693570
ToppCellCOPD-Epithelial-ATII|Epithelial / Disease state, Lineage and Cell class

GPHN DPYD NEDD4L ANK3

1.91e-04187684030af361f8bdcd0aff4ec1922702833325cf74d8
ToppCellE17.5-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

WDR45 NEDD4L ANK3 WLS

2.03e-041906848e9ba1f1af520564a1a7dfa9ef74ef5f0d0bf0d5
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANK3 SYT11 SPTBN1 CORO1B

2.03e-0419068491ba66d4b56c59523485b17738e93f14bb00afa4
ToppCellE17.5-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PARD6B WDR45 NEDD4L WLS

2.03e-0419068415f314517ed47b12d287a12a7d18cb383310e25a
ToppCellE17.5-Epithelial-epithelial_progenitor_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

WDR45 NEDD4L ANK3 WLS

2.07e-0419168468b717fce7d9349ef56255ee0c5e57fc67e50fd8
ToppCellControl-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

PARD6B NEDD4L ANK3 SPTBN1

2.11e-041926841bfd022d5b87cf8a5d5069f559339a553a52a0a2
ToppCell(210)_NKT_cell|World / immune cells in Peripheral Blood (logTPM normalization)

DIP2A DLG5 SYT11 CCDC92

2.11e-0419268408dc0c019c594da7b9944db8fd706aa7780e6ae9
ToppCell(21)_NKT_cell|World / immune cells in Peripheral Blood (logTPM normalization)

DIP2A DLG5 SYT11 CCDC92

2.11e-04192684b0a573ddde2978485a857b8261ee1ee5ef68ecef
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GPHN PARD6B NEDD4L ANK3

2.16e-041936843866667dd221612589ae50f5c52f73a183a49ce6
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GPHN PARD6B NEDD4L ANK3

2.16e-0419368482e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCellRA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

NEDD4L ANK2 ANK3 EDA

2.20e-0419468489812fb164065041357bb37a3c2d87028ec3de4e
ToppCellRA-03._Atrial_Cardiomyocyte|RA / Chamber and Cluster_Paper

NEDD4L ANK2 ANK3 EDA

2.20e-04194684c3535f7cc0076653c72db582047cff053c322397
ToppCellPND01-Epithelial|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PARD6B WDR45 NEDD4L ANK3

2.20e-04194684d21db5e942966ed44bc78ff50130a201fc627074
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PARD6B ADGRG7 NEDD4L FAM135A

2.20e-0419468454975e663ed4414b99b3c9a1aa6335613946470f
ToppCellnucseq-Epithelial-Epithelial_Alveolar|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GPHN PARD6B NEDD4L ANK3

2.20e-0419468453f3e49e91b1096f3226010e2de767efb490dfe4
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

NEDD4L ANK3 CEP112 SPTBN1

2.24e-04195684fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellPND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PARD6B WDR45 NEDD4L ANK3

2.24e-0419568443164511f32e4591cb5399182fbac0b911716233
ToppCellPND01-Epithelial-Epithelial_Alveolar|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PARD6B WDR45 NEDD4L ANK3

2.24e-041956849337111d75a487abc02969337718c30b1fe81379
ToppCellControl-Multiplet|Control / Disease state, Lineage and Cell class

PARD6B NEDD4L ANK3 SPTBN1

2.24e-04195684618900c80bea09d46dad3f741bd1bff8bf0a64ee
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

NEDD4L ANK3 CEP112 SPTBN1

2.24e-04195684eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCellControl-Multiplet-Multiplet|Control / Disease state, Lineage and Cell class

PARD6B NEDD4L ANK3 SPTBN1

2.24e-0419568406ac685855e14e4dd2cbe6d0e73f894f2eeff91f
ToppCellnucseq-Epithelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GPHN PARD6B NEDD4L ANK3

2.24e-041956849406866f99555198a9be311fbd65751b70f35446
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

OSTN CORO1B CAPS2 DNAH8

2.29e-04196684511e9846d204b2346b17d1a4142c3bb484b08e32
ToppCelldroplet-Kidney-nan-3m-Epithelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THAP4 ANK3 SPTBN1 WLS

2.29e-041966849f39cb3de886283da34ee7511a92d94930a6c851
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PARD6B WDR45 SPTBN1 WLS

2.29e-041966849790340c25f446ec655f5a0b64ec3bb44ed2e1bd
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PARD6B WDR45 SPTBN1 WLS

2.29e-04196684b9ceceeacbcf81976ce92adf044f0d0aa132632b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PARD6B NEDD4L ANK2 ANK3

2.29e-04196684eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCellEpithelial-A_(AT1)|World / shred on cell class and cell subclass (v4)

PARD6B WDR45 SPTBN1 WLS

2.29e-04196684484bbc6b1f58bc260964babb949d14f5df101393
ToppCelldroplet-Kidney-nan-3m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THAP4 ANK3 SPTBN1 WLS

2.29e-04196684b880c9665d42c76ea1971d4e49d7ecf72fcfafb6
ToppCellAT2_cells-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

PARD6B ADGRG7 NEDD4L SPTBN1

2.33e-04197684c36513e893488c4299119d4fba6ef0fd72610ee6
ToppCellSevere-B_intermediate-6|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SYT11 CORO1B DNAH8 ACTR2

2.38e-041986848402421dc060926e968efe39a4e907f1e8ae5b1f
ToppCellmild-CD4+_T_naive|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ANK3 SPTBN1 KMT2A EDA

2.42e-041996843e4baaf4ee23f257d821194468102c00a8ad2f21
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6|World / Primary Cells by Cluster

DPYD ANK2 ANK3 OSTN

2.42e-041996841b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DIP2A ARID1B ANK3 VPS13A

2.42e-04199684f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellEpithelial_cells|World / lung cells shred on cell class, cell subclass, sample id

PARD6B NEDD4L ANK3 SPTBN1

2.42e-04199684bbe69e44b7970f57628365ae771790f2b13d0cae
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal|World / Primary Cells by Cluster

DPYD ANK2 ANK3 OSTN

2.42e-041996844bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIP2A ANK2 SYT11 ERMP1

2.47e-042006840e85c90719d9ec51a566e230c9dd2909d8df1f52
ToppCellfacs-Brain_Non-Myeloid-Hippocampus|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIP2A SYT11 TRIM35 ERMP1

2.47e-04200684fc28f71ca1cd0fdae66009ae5afe175d22f2bd8c
ToppCellParenchymal-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DIP2A ERMP1 CAPS2 NYAP1

2.47e-0420068436de49593cf6ff1c9229fcceb150c1d68658a360
ToppCellSepsis-ICU-SEP-Myeloid-cDC2|ICU-SEP / Disease, condition lineage and cell class

PARD6B VAC14 ANK3 FAM135A

2.47e-0420068409d5c3a3d2b42b15c769dc2bc14b6c0d5cc38f91
DiseaseNeurodevelopmental Disorders

WDR45 ARID1B ANK2 IQSEC2 KMT2A

2.31e-0693675C1535926
Diseasespinocerebellar ataxia type 5 (implicated_via_orthology)

SPTBN1 SPTBN2

3.04e-054672DOID:0050882 (implicated_via_orthology)
Diseaseperiventricular nodular heterotopia (is_implicated_in)

NEDD4L ARFGEF2

7.57e-056672DOID:0050454 (is_implicated_in)
DiseasePeriventricular Nodular Heterotopia

NEDD4L ARFGEF2

1.06e-047672C1868720
Diseaseunipolar depression, response to escitalopram, response to citalopram, mood disorder

SLC24A3 CORO1B

5.23e-0415672EFO_0003761, EFO_0004247, EFO_0006329, EFO_0007871
Diseasesusceptibility to mononucleosis measurement

FAM47A ZBTB9 DNAH8

5.27e-0469673EFO_0008403
Diseasenicotine dependence symptom count, depressive symptom measurement

OSTN ARFGEF2 SLC24A3

6.72e-0475673EFO_0007006, EFO_0009262
Diseasecortical surface area measurement

MSX2 ARID1B CSGALNACT2 ANK3 CEP112 SPTBN1 MDC1 OSTN EXTL3 WLS

8.70e-0413456710EFO_0010736
DiseaseEpilepsy, Cryptogenic

WDR45 ARID1B IQSEC2

8.72e-0482673C0086237
DiseaseAwakening Epilepsy

WDR45 ARID1B IQSEC2

8.72e-0482673C0751111
DiseaseAura

WDR45 ARID1B IQSEC2

8.72e-0482673C0236018
DiseaseColorectal Carcinoma

DPYD ANK2 SPTBN2 VPS13A CORO1B EDA DNAH8

1.06e-03702677C0009402
Diseaseunipolar depression, depressive symptom measurement

ARFGEF2 KMT2A

1.59e-0326672EFO_0003761, EFO_0007006
DiseaseAcute monocytic leukemia

FANCB KMT2A

1.59e-0326672C0023465
Diseasecortical surface area measurement, neuroimaging measurement

CEP112 SPTBN1 OSTN WLS

1.79e-03227674EFO_0004346, EFO_0010736
DiseaseEpilepsy

WDR45 ARID1B IQSEC2

1.98e-03109673C0014544
Diseaselung carcinoma, family history of lung cancer

MSX2 SYT11

1.98e-0329672EFO_0001071, EFO_0006953
DiseaseEpileptic encephalopathy

GPHN NEDD4L

2.12e-0330672C0543888

Protein segments in the cluster

PeptideGeneStartEntry
PYIKMTILPDKRHRV

SYT11

196

Q9BT88
PDSKMTPLRFRKRTL

CAPS2

261

Q9BXY5
PIKLARLVMEKTPHC

ASRGL1

101

Q7L266
PFEHIMKKNRSPTIR

ARFGEF2

1186

Q9Y6D5
VVDMKPFVLKLPHRT

CEP112

21

Q8N8E3
HERKCEPIVMTVPRK

CORO1B

341

Q9BR76
CIKMVSRTTPYEPKR

DPYD

1001

Q12882
QTHFESKMEIPPRRR

ARID1B

1901

Q8NFD5
CRPHRKTFMPSLVVK

C8orf58

341

Q8NAV2
IRTMKPLPRHFILFI

ADGRG7

556

Q96K78
PKPKRVFLQHMTRTF

ERMP1

681

Q7Z2K6
KIRIEDPPRRKHMVF

ACTR2

341

P61160
HKFSFDIMPTARPKR

RTN4RL1

386

Q86UN2
KVARRHRMSPFPLTS

GPHN

311

Q9NQX3
RKKPHIVISMPQDFR

PARD6B

126

Q9BYG5
TLEPRRRKFHKPITM

ANK2

1221

Q01484
RSRMTHRTPKVKKSP

LRRC37A3

1311

O60309
FHPKPKIRTRKSSRM

MDC1

1101

Q14676
AKVKHSRPRREMASP

LILRB4

361

Q8NHJ6
RMIVGKKPVLSLPHR

IQSEC2

956

Q5JU85
RASMKIPSRIPHRVE

FAM135A

31

Q9P2D6
MVHRFSKRRDSPLPV

OR51E1

261

Q8TCB6
ATVRKLAKPPHLIMR

DNAH8

3171

Q96JB1
MHASPPRKARVRIAS

DLG5

1061

Q8TDM6
RRKTPRHKQPTLLMV

C6orf223

26

Q8N319
RIMITSHFPPKTRLS

SLC24A3

331

Q9HC58
PPIHLHRMKSLIRSK

LRRC66

306

Q68CR7
RKVVDHPKRRFGIPM

OSTN

106

P61366
EPTKTPILHVRRMVF

FANCB

36

Q8NB91
SVRPMHERVPKKEVK

OCIAD1

221

Q9NX40
RITMNPKVFKLHPRS

EDA

276

Q92838
RHVTLFRPFGPLMKV

CSGALNACT2

246

Q8N6G5
TPRRRMKKSLSAPLH

CCDC92

201

Q53HC0
KFVLGPTPARRHMVK

FRS3

241

O43559
MNFLVSHITRKPPIK

EXTL3

836

O43909
RHHGMRIIIPPRKCT

ANK3

1001

Q12955
EPRRRKFHKPITMTI

ANK3

1206

Q12955
AKCKHRRLRFPPMDT

FAM47A

31

Q5JRC9
TRFDMHKRSPLLRAP

KMT2A

686

Q03164
RKMPMPSKRRSVLVH

DIP2A

111

Q14689
IKTPAFHPQRMIISR

NPIPB13

576

A6NJU9
PMRSKKIFGSVHPVR

PTX3

186

P26022
AKPRRHPSTKLSMVG

NYAP1

116

Q6ZVC0
PRHMSPTTCTLRKHK

MSX2

126

P35548
RIKFTHCLVPKMPTN

GARIN1A

186

Q6NXP2
VHSPDRMLDSPKRKR

MCM9

881

Q9NXL9
APFKPITRKSVGHRM

MRPL16

126

Q9NX20
KTPRKMFRHTDSLFP

VAC14

431

Q08AM6
HKSRKRRLFCTMEPE

TRIM35

256

Q9UPQ4
RKQVLTKPSVHMPER

SPATA31C2

716

B4DYI2
FTKPVLSVRMRHDKI

WDR45

101

Q9Y484
QRRATPHPSELKVMK

SCRIB

471

Q14160
PKPTKGRMRIHCLEN

SPTBN1

101

Q01082
HITIPRKRMFTPRKL

CLBA1

301

Q96F83
KAFISLPSVRRHMIK

ZNF564

176

Q8TBZ8
KRPHVKKATPRMIGL

VPS13A

1461

Q96RL7
EILPKPTKGRMRIHC

SPTBN2

101

O15020
TKRRPPLSHMISLFI

TMEM94

676

Q12767
VPPKMKRGTSLHSRR

TMCC1

111

O94876
APLMFSRRHSLKKVP

TEX13C

621

A0A0J9YWL9
SRRHSLKKVPVMPKE

TEX13C

626

A0A0J9YWL9
FSRRHSLKKVPVMPK

TEX13C

686

A0A0J9YWL9
KHRPLEMSAKIRVPF

RRP36

91

Q96EU6
TREMPQSKPKLRSRH

TTLL2

501

Q9BWV7
DRAFPLKPMVHRKSC

ZC2HC1C

136

Q53FD0
RFAVKPKRDRHIMLT

ZBTB9

391

Q96C00
PKRDRHIMLTFSLRP

ZBTB9

396

Q96C00
KVVHRPMGTRKHLVP

WNT11

246

O96014
MAHERVPRKLKCTFT

WLS

151

Q5T9L3
RKPMHRECGFIRLKP

THAP4

476

Q8WY91
MPLIVPCTVHTRKKD

USP6

901

P35125
EHIIMKPACPLFVRR

TMEM33

216

P57088
EDPRLKFPVHMRSKT

NEDD4L

526

Q96PU5