Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

MAML1 ZNF462 CREBRF KMT2C NCOA6 IRF2BPL ZFHX3 REST SSBP4 BCL9 MITF

2.07e-0613903011GO:0045944
GeneOntologyBiologicalProcessmyoblast differentiation

MAML1 ZFHX3 REST BCL9

4.34e-05136304GO:0045445
GeneOntologyBiologicalProcessnegative regulation of transcription by RNA polymerase II

CPEB3 CREBRF KLF3 IRF2BPL ZFHX3 MAGEL2 REST MITF

9.61e-051053308GO:0000122
GeneOntologyCellularComponentMLL3/4 complex

KMT2C NCOA6

1.30e-0412302GO:0044666
DomainUBA-like

UBALD2 UBALD1

5.04e-0364312IPR009060
PathwayWP_KLEEFSTRA_SYNDROME

KMT2C NCOA6 MBD5

1.35e-0529233M48076
Pubmed

Interaction network of human early embryonic transcription factors.

MAML1 ZNF462 KLF3 KMT2C NCOA6 ZFHX3 BCL9 PRRC2B MITF

2.24e-1135132938297188
Pubmed

Human transcription factor protein interaction networks.

MAML1 ZNF462 KLF3 KMT2C NCOA6 IRF2BPL ZFHX3 SSBP4 BCL9 ANKHD1 PRRC2B MITF

2.33e-091429321235140242
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

NCOA6 IRF2BPL MAGEL2 TSC22D2 BCL9 MITF

2.38e-0643032635044719
Pubmed

Activating signal cointegrator-2 is an essential adaptor to recruit histone H3 lysine 4 methyltransferases MLL3 and MLL4 to the liver X receptors.

KMT2C NCOA6

2.46e-06332218372346
Pubmed

Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis.

KMT2C NCOA6

2.46e-06332221330447
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

MAML1 KMT2C NCOA6 BCL9 ANKHD1 PRRC2B

3.38e-0645732632344865
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MAML1 KMT2C NCOA6 SSBP4 BCL9 MBD5 ANKHD1 PRRC2B

5.40e-06110532835748872
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MAML1 KMT2C NCOA6 SIK3 ANKHD1 NCAPH

7.80e-0652932614621295
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

ATXN2L KMT2C NCOA6 ANKHD1 NCAPH PRRC2B

9.62e-0654932638280479
Pubmed

A global genomic transcriptional code associated with CNS-expressed genes.

CPEB3 ZNF462 ZFHX3 MMS22L MITF

1.02e-0531832516919269
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

MAML1 ATXN2L BCL9 PRRC2B

1.15e-0515232438360978
Pubmed

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.

KMT2C NCOA6

1.23e-05632217021013
Pubmed

A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4.

KMT2C NCOA6

1.72e-05732219433796
Pubmed

ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.

KMT2C NCOA6

1.72e-05732219556342
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

KMT2C IRF2BPL SIK3 MBD5 NCAPH PRRC2B

3.45e-0568932636543142
Pubmed

Chromosomal localisation, inducibility, tissue-specific expression and strain differences in three murine peroxisome-proliferator-activated-receptor genes.

TYMP MITF

3.67e-05103227588749
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

ZNF462 KMT2C IRF2BPL ZFHX3

4.88e-0522032435785414
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

ZNF462 KMT2C NCOA6 SIK3

5.32e-0522532412168954
Pubmed

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.

KMT2C NCOA6

6.36e-051332217761849
Pubmed

Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.

KMT2C NCOA6

7.41e-051432212482968
Pubmed

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.

KMT2C NCOA6

8.55e-051532217925232
Pubmed

High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization.

KMT2C REST ANKHD1

8.96e-059432316325481
Pubmed

SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.

KMT2C NCOA6

9.76e-051632223870121
Pubmed

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.

KMT2C NCOA6

9.76e-051632224368734
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

MAML1 NCOA6 BCL9 PRRC2B

1.05e-0426832433640491
Pubmed

MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.

KMT2C NCOA6

1.11e-041732226180087
Pubmed

Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.

ZNF462 CREBRF ZFHX3 REST MBD5

1.22e-0453632515840001
Pubmed

Exchangeable gene trap using the Cre/mutated lox system.

ZNF462 CREBRF ZFHX3 REST MBD5

1.24e-0453832510512203
Pubmed

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

KMT2C NCOA6

1.24e-041832217500065
Pubmed

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.

KMT2C NCOA6

1.54e-042032229785026
Pubmed

Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.

KMT2C NCOA6

1.54e-042032219047629
Pubmed

A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.

ZNF462 BCL9

1.70e-042132224025145
Pubmed

Structural basis for activity regulation of MLL family methyltransferases.

KMT2C NCOA6

1.87e-042232226886794
Pubmed

Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.

CPEB3 REST SNAP91

2.23e-0412832330995482
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

MAML1 NCOA6 SIK3 BCL9 PRRC2B

2.73e-0463832531182584
Pubmed

Control of developmentally primed erythroid genes by combinatorial co-repressor actions.

IRF2BPL SSBP4

3.51e-043032226593974
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

ZNF462 KLF3 KMT2C ZFHX3 REST

4.43e-0470932522988430
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

MAML1 ATXN2L KMT2C NCOA6 BCL9 PRRC2B

4.49e-04110332634189442
Pubmed

Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.

ZFHX3 REST

5.65e-043832228218735
Pubmed

Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination.

KMT2C MYRFL

6.58e-044132234638806
Pubmed

Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

MAML1 NCOA6

6.58e-04413228724849
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

ATXN2L NCOA6 IRF2BPL REST BCL9

6.59e-0477432515302935
Pubmed

Impact of WIN site inhibitor on the WDR5 interactome.

ZNF462 KMT2C

7.23e-044332233472061
Pubmed

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.

ZNF462 MBD5 PRRC2B MITF

8.30e-0446332427503909
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

ZNF462 KMT2C REST NCAPH

8.70e-0446932427634302
Pubmed

Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin.

KMT2C NCOA6

9.01e-044832227703004
InteractionEGR2 interactions

MAML1 ZNF462 KMT2C NCOA6 ZFHX3 BCL9 PRRC2B MITF

2.02e-10171328int:EGR2
InteractionFEV interactions

MAML1 ZNF462 KMT2C NCOA6 ZFHX3 BCL9 PRRC2B

2.58e-08203327int:FEV
InteractionSOX2 interactions

MAML1 ZNF462 CEP170P1 ATXN2L KLF3 KMT2C NCOA6 ZFHX3 BCL9 TYMP ANKHD1 PRRC2B MITF

9.94e-0814223213int:SOX2
InteractionERG interactions

MAML1 KMT2C NCOA6 BCL9 PRRC2B MITF

1.22e-06223326int:ERG
InteractionPAX6 interactions

ZNF462 KMT2C NCOA6 ZFHX3 BCL9 PRRC2B MITF

1.40e-06366327int:PAX6
InteractionPAX7 interactions

MAML1 KMT2C ZFHX3 SSBP4 BCL9

1.43e-06124325int:PAX7
InteractionPAX9 interactions

MAML1 KMT2C NCOA6 ZFHX3 BCL9

1.81e-06130325int:PAX9
InteractionCRX interactions

MAML1 ZNF462 KMT2C ZFHX3 BCL9 PRRC2B

2.60e-06254326int:CRX
InteractionSP7 interactions

MAML1 KMT2C NCOA6 BCL9 PRRC2B MITF

7.30e-06304326int:SP7
InteractionTLX1 interactions

MAML1 ZNF462 KMT2C ZFHX3 BCL9

7.76e-06175325int:TLX1
InteractionGSC interactions

ZNF462 KMT2C ZFHX3 BCL9

1.06e-0587324int:GSC
InteractionHNF1B interactions

MAML1 KMT2C ZFHX3 BCL9 PRRC2B

1.16e-05190325int:HNF1B
InteractionKLF5 interactions

MAML1 KMT2C NCOA6 BCL9 PRRC2B

1.31e-05195325int:KLF5
InteractionGATA2 interactions

KMT2C NCOA6 ZFHX3 BCL9 PRRC2B

1.45e-05199325int:GATA2
InteractionPAX8 interactions

MAML1 KMT2C BCL9 PRRC2B

2.78e-05111324int:PAX8
InteractionTBR1 interactions

MAML1 KMT2C ZFHX3 BCL9

2.99e-05113324int:TBR1
InteractionTBXT interactions

MAML1 KMT2C NCOA6 BCL9

3.31e-05116324int:TBXT
InteractionNUP35 interactions

MAML1 KMT2C NCOA6 BCL9 ANKHD1 PRRC2B

4.77e-05424326int:NUP35
InteractionNFIB interactions

MAML1 KLF3 KMT2C BCL9

7.29e-05142324int:NFIB
InteractionLHX8 interactions

KLF3 SSBP4 BCL9

8.07e-0553323int:LHX8
InteractionTLX3 interactions

MAML1 KMT2C NCOA6 ZFHX3 BCL9

8.87e-05291325int:TLX3
InteractionLHX6 interactions

KLF3 SSBP4 BCL9

1.06e-0458323int:LHX6
InteractionAR interactions

MAML1 ZNF462 KMT2C NCOA6 IRF2BPL ZFHX3 BCL9 PRRC2B

1.22e-04992328int:AR
InteractionFOS interactions

KMT2C NCOA6 BCL9 ANKHD1 MITF

1.23e-04312325int:FOS
InteractionEHMT2 interactions

ZNF462 KLF3 IRF2BPL REST PRRC2B

1.29e-04315325int:EHMT2
InteractionGCM1 interactions

KMT2C BCL9 PRRC2B

1.70e-0468323int:GCM1
InteractionASCL2 interactions

KMT2C NCOA6

1.88e-0413322int:ASCL2
InteractionLHX2 interactions

KMT2C ZFHX3 SSBP4 BCL9

1.94e-04183324int:LHX2
InteractionFOXL1 interactions

KMT2C ZFHX3 BCL9 NCAPH

2.52e-04196324int:FOXL1
InteractionTLE3 interactions

MAML1 KLF3 ZFHX3 SSBP4 BCL9

2.93e-04376325int:TLE3
InteractionDPY30 interactions

KMT2C NCOA6 MBD5 PRRC2B

2.94e-04204324int:DPY30
InteractionSOX17 interactions

KMT2C NCOA6 BCL9

4.56e-0495323int:SOX17
InteractionSOX9 interactions

KMT2C NCOA6 BCL9

4.84e-0497323int:SOX9
InteractionDDX3X interactions

ATXN2L MAGEL2 REST MBD5 ANKHD1 PRRC2B

4.91e-04651326int:DDX3X
InteractionWWTR1 interactions

ATXN2L NCOA6 ANKHD1 NCAPH PRRC2B

4.97e-04422325int:WWTR1
InteractionEYA4 interactions

MAML1 ATXN2L BCL9 PRRC2B

5.69e-04243324int:EYA4
InteractionLHX1 interactions

KMT2C SSBP4 BCL9

5.77e-04103323int:LHX1
InteractionH2BC12L interactions

CEP170P1 REST

6.05e-0423322int:H2BC12L
InteractionUTY interactions

KMT2C NCOA6

6.05e-0423322int:UTY
InteractionSSBP2 interactions

SSBP4 BCL9 TYMP

6.11e-04105323int:SSBP2
InteractionTLE6 interactions

MAML1 SSBP4

7.16e-0425322int:TLE6
InteractionLDB1 interactions

ZFHX3 SSBP4 BCL9

7.96e-04115323int:LDB1
InteractionPYGO1 interactions

SSBP4 BCL9

9.00e-0428322int:PYGO1
InteractionRCOR1 interactions

KLF3 ZFHX3 REST ANKHD1 NCAPH

1.01e-03494325int:RCOR1
Cytoband11p15.5

C11orf21 CDHR5

3.09e-0311832211p15.5
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF462 KLF3 ZFHX3

1.32e-0271813328
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN

ZNF462 KLF3 KMT2C NCOA6 ZFHX3 REST BCL9 ANKHD1

6.91e-08467328M1347
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN

ZNF462 KLF3 KMT2C NCOA6 ZFHX3 REST BCL9 ANKHD1

9.09e-08484328MM999
CoexpressionGSE17721_LPS_VS_PAM3CSK4_24H_BMDC_DN

ZFHX3 CHCHD10 SSBP4 NCAPH UBALD1

4.19e-06200325M3931
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

CPEB3 ZNF462 CREBRF IRF2BPL ZFHX3 SIK3 SNAP91 PRRC2B

4.17e-051106328M39071
CoexpressionGSE13738_RESTING_VS_BYSTANDER_ACTIVATED_CD4_TCELL_UP

CREBRF KMT2C BCL9 PRRC2B

8.90e-05194324M3321
CoexpressionGSE19888_CTRL_VS_A3R_INHIBITOR_TREATED_MAST_CELL_DN

CREBRF KLF3 SIK3 TSC22D2

9.07e-05195324M7310
CoexpressionGSE369_PRE_VS_POST_IL6_INJECTION_IFNG_WT_LIVER_DN

MAML1 CREBRF KLF3 UBALD2

1.00e-04200324M5980
CoexpressionLAKE_ADULT_KIDNEY_C14_DISTAL_CONVOLUTED_TUBULE

SIK3 TSC22D2 MBD5 MITF

1.16e-04208324M39233
CoexpressionGUO_HEX_TARGETS_UP

ZFHX3 MAGEL2 REST

1.18e-0478323M1436
CoexpressionGUO_HEX_TARGETS_UP

ZFHX3 MAGEL2 REST

1.27e-0480323MM626
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_TTD_DN

ZFHX3 TSC22D2 MITF

1.47e-0484323M13008
CoexpressionSUZUKI_AMPLIFIED_IN_ORAL_CANCER

BCL9 MITF

1.94e-0417322M15351
CoexpressionZWANG_EGF_INTERVAL_DN

CPEB3 KLF3 IRF2BPL BCL9

1.95e-04238324M2620
CoexpressionLAKE_ADULT_KIDNEY_C21_COLLECTING_DUCT_INTERCALATED_CELLS_TYPE_B

KMT2C SIK3 MITF

2.69e-04103323M39240
DiseaseParoxysmal atrial fibrillation

ZNF462 IRF2BPL ZFHX3 MBD5 MYPN

6.95e-07156325C0235480
Diseasefamilial atrial fibrillation

ZNF462 IRF2BPL ZFHX3 MBD5 MYPN

6.95e-07156325C3468561
DiseasePersistent atrial fibrillation

ZNF462 IRF2BPL ZFHX3 MBD5 MYPN

6.95e-07156325C2585653
DiseaseAtrial Fibrillation

ZNF462 IRF2BPL ZFHX3 MBD5 MYPN

7.88e-07160325C0004238
Diseasefeeling nervous measurement

NCOA6 IRF2BPL MMS22L MBD5

2.38e-0687324EFO_0009597
Diseasebody fat percentage

ATXN2L KLF3 ZFHX3 MMS22L TSC22D2 PRRC2B

1.25e-05488326EFO_0007800
Diseaseaspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement

ATXN2L KLF3 ZFHX3 MMS22L TSC22D2

4.26e-05364325EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Diseaseforced expiratory volume

ATXN2L NCOA6 REST BCL9 PRRC2B MYPN

1.79e-04789326EFO_0004314
DiseaseQT interval

ATXN2L ZFHX3 MBD5 PRRC2B MITF

2.56e-04534325EFO_0004682
Diseasebrain measurement, neuroimaging measurement

ZNF462 ATXN2L ZFHX3 TSC22D2 MITF

2.93e-04550325EFO_0004346, EFO_0004464
Diseasevital capacity

ATXN2L NCOA6 ZFHX3 MMS22L SSBP4 UBALD1 MYPN

2.98e-041236327EFO_0004312
Diseasemyeloid white cell count

KLF3 ZFHX3 REST SIK3 SSBP4 BCL9

4.51e-04937326EFO_0007988
Diseaselung non-small cell carcinoma (is_implicated_in)

KMT2C ZFHX3 TYMP

4.59e-04139323DOID:3908 (is_implicated_in)
Diseasecaudate nucleus volume

ATXN2L ZFHX3

4.86e-0430322EFO_0004830
Diseasetriacylglycerol 54:3 measurement

SIK3 MYPN

5.20e-0431322EFO_0010421
Diseasetriacylglycerol 54:5 measurement

MMS22L SIK3

5.54e-0432322EFO_0010423
Diseaseneuroimaging measurement

ZNF462 ATXN2L KLF3 TSC22D2 SNAP91 MITF

9.00e-041069326EFO_0004346
Diseasemonocyte percentage of leukocytes

CPEB3 MAML1 KLF3 SSBP4 MBD5

1.06e-03731325EFO_0007989
Diseasesexual dimorphism measurement

ZNF462 ATXN2L NCOA6 ZFHX3 REST SIK3

1.07e-031106326EFO_0021796

Protein segments in the cluster

PeptideGeneStartEntry
MPQPSVSGMDPPFGD

CREBRF

1

Q8IUR6
MPTMAPAGQPAPVSM

SNAP91

726

O60641
PMPPSMGTSTSHQPA

CDHR5

581

Q9HBB8
PASAPPMMQAAAAAG

ATXN2L

761

Q8WWM7
PNRPMAPMSSAAAVG

MAML1

886

Q92585
AQMDPPQMGPAPTEA

REST

606

Q13127
PFGVPLSMPPVMAAA

KLF3

116

P57682
PTPPPMACQKMANGF

KMT2C

3906

Q8NEZ4
APMTQPPASGAPMAQ

MAGEL2

296

Q9UJ55
APMAQPAAPPAQPMA

MAGEL2

306

Q9UJ55
MDMPSTAPSDFQPQP

MMS22L

751

Q6ZRQ5
APQNGPSPMAALMSV

IRF2BPL

616

Q9H1B7
AAPAMPPMHPLQSTS

MYRFL

91

Q96LU7
SSSMMAPGPNPELQP

NCOA6

191

Q14686
APPAPNGPDKMQMES

CPEB3

61

Q8NE35
PAPSGQPGLMAQMAT

CHCHD10

36

Q8WYQ3
PARSPNLPSMNNMPG

BCL9

1041

O00512
TAPSMPGHNPMRPPA

BCL9

1306

O00512
MPGQPTLMSNPAAAV

BCL9

1341

O00512
ALNNMGFPSAMLPSP

CEP170P1

211

Q96L14
NFMMPPVGPQATSSG

MBD5

471

Q9P267
PGAATGPQPMMAAAQ

TSC22D2

296

O75157
SNSPPPMSSAMIQPH

SIK3

746

Q9Y2K2
PMSMPFASNSEPAPL

ANKHD1

2091

Q8IWZ3
MGPPGPALPATMNNS

NCAPH

1

Q15003
APGSMMPPAAAQPSA

C11orf21

51

Q9P2W6
PVPGSSAPNSPMAML

MITF

171

O75030
PPNSLAGPGLPAMNM

SSBP4

221

Q9BWG4
PMPVASVAPSASMPG

PRRC2B

1906

Q5JSZ5
MMCTPSNTPATPPNF

UBALD2

61

Q8IYN6
GAPMSPKMSNMGSPP

ZNF462

1086

Q96JM2
MAALMTPGTGAPPAP

TYMP

1

P19971
MMCTPANTPATPPNF

UBALD1

61

Q8TB05
FQLDPAGPMAAMTPA

ZFHX3

891

Q15911
PPTNAMGLPRSAPSM

MYPN

841

Q86TC9