Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	KLF11 ZBTB2 KMT2D SALL1 ZNF560 ZNF341 NFX1 ZNF432 MECOM ZNF778 ZNF76 ZFP69B SIM2 ZNF236 ZBTB11 ZNF614 AR ZNF443 ZNF284	2.98e-10	1412	49	19	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	KLF11 ZBTB2 SALL1 ZNF560 ZNF341 NFX1 ZNF432 MECOM ZNF778 ZNF76 ZFP69B SIM2 ZNF236 ZBTB11 ZNF614 AR ZNF443 ZNF691 ZNF284	5.19e-10	1459	49	19	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	KLF11 ZBTB2 SALL1 ZNF341 ZNF432 MECOM ZNF778 ZNF76 ZNF236 ZBTB11 AR ZNF691 ZNF284	6.38e-06	1244	49	13	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	KLF11 ZBTB2 SALL1 ZNF341 ZNF432 MECOM ZNF778 ZNF76 ZNF236 ZBTB11 AR ZNF691 ZNF284	8.05e-06	1271	49	13	GO:0000987
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2C KMT2D	1.64e-04	8	49	2	GO:0140945
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	KMT2C KMT2D MECOM	1.71e-04	44	49	3	GO:0140938
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2C KMT2D	2.62e-04	10	49	2	GO:0140999
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	KMT2C KMT2D MECOM	6.22e-04	68	49	3	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	KMT2C KMT2D MECOM	6.49e-04	69	49	3	GO:0016278
GeneOntologyMolecularFunction	histone methyltransferase activity	KMT2C KMT2D MECOM	7.06e-04	71	49	3	GO:0042054
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2C KMT2D	1.09e-03	20	49	2	GO:0042800
GeneOntologyMolecularFunction	protein methyltransferase activity	KMT2C KMT2D MECOM	2.07e-03	103	49	3	GO:0008276
GeneOntologyMolecularFunction	N-methyltransferase activity	KMT2C KMT2D MECOM	2.18e-03	105	49	3	GO:0008170
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	KMT2D ZNF341 MECOM ZNF778 ZNF76 AR	2.51e-03	566	49	6	GO:0001216
GeneOntologyMolecularFunction	ubiquitin conjugating enzyme binding	SIAH2 RNF217	3.52e-03	36	49	2	GO:0031624
GeneOntologyBiologicalProcess	ureteric bud invasion	SALL1 KIF26B	1.59e-05	3	48	2	GO:0072092
GeneOntologyBiologicalProcess	metanephric renal vesicle formation	SALL1 KIF26B	3.17e-05	4	48	2	GO:0072093
GeneOntologyBiologicalProcess	ureteric bud elongation	SALL1 KIF26B	1.47e-04	8	48	2	GO:0060677
GeneOntologyBiologicalProcess	renal vesicle formation	SALL1 KIF26B	1.47e-04	8	48	2	GO:0072033
GeneOntologyCellularComponent	MLL3/4 complex	KMT2C KMT2D	3.50e-04	12	49	2	GO:0044666
Domain	-	ZNF462 KLF11 ZBTB2 SALL1 ZNF560 ZNF341 ZNF432 MECOM ZNF778 ZNF76 ZFP69B ZNF236 ZBTB11 ZNF614 ZNF443 ZNF691 ZNF284	2.75e-13	679	47	17	3.30.160.60
Domain	zf-C2H2	ZNF462 KLF11 ZBTB2 SALL1 ZNF560 ZNF341 ZNF432 MECOM ZNF778 ZNF76 ZFP69B ZNF236 ZBTB11 ZNF614 ZNF443 ZNF691 ZNF284	3.82e-13	693	47	17	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF462 KLF11 ZBTB2 SALL1 ZNF560 ZNF341 ZNF432 MECOM ZNF778 ZNF76 ZFP69B ZNF236 ZBTB11 ZNF614 ZNF443 ZNF691 ZNF284	3.91e-13	694	47	17	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF462 KLF11 ZBTB2 SALL1 ZNF560 ZNF341 ZNF432 MECOM ZNF778 ZNF76 ZFP69B ZNF236 ZBTB11 ZNF614 ZNF443 ZNF691 ZNF284	2.30e-12	775	47	17	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF462 KLF11 ZBTB2 SALL1 ZNF560 ZNF341 ZNF432 MECOM ZNF778 ZNF76 ZFP69B ZNF236 ZBTB11 ZNF614 ZNF443 ZNF691 ZNF284	2.39e-12	777	47	17	PS00028
Domain	Znf_C2H2-like	ZNF462 KLF11 ZBTB2 SALL1 ZNF560 ZNF341 ZNF432 MECOM ZNF778 ZNF76 ZFP69B ZNF236 ZBTB11 ZNF614 ZNF443 ZNF691 ZNF284	3.52e-12	796	47	17	IPR015880
Domain	Znf_C2H2	ZNF462 KLF11 ZBTB2 SALL1 ZNF560 ZNF341 ZNF432 MECOM ZNF778 ZNF76 ZFP69B ZNF236 ZBTB11 ZNF614 ZNF443 ZNF691 ZNF284	4.21e-12	805	47	17	IPR007087
Domain	ZnF_C2H2	ZNF462 KLF11 ZBTB2 SALL1 ZNF560 ZNF341 ZNF432 MECOM ZNF778 ZNF76 ZFP69B ZNF236 ZBTB11 ZNF614 ZNF443 ZNF691 ZNF284	4.46e-12	808	47	17	SM00355
Domain	zf-C2H2_6	ZNF560 ZNF432 MECOM ZNF778 ZFP69B ZNF236 ZBTB11 ZNF443 ZNF284	7.44e-08	314	47	9	PF13912
Domain	Ribosomal_S27e	RPS27 RPS27L	6.20e-06	2	47	2	IPR000592
Domain	-	RPS27 RPS27L	6.20e-06	2	47	2	2.20.25.100
Domain	Ribosomal_S27e_Zn-bd_dom	RPS27 RPS27L	6.20e-06	2	47	2	IPR023407
Domain	Ribosomal_S27e	RPS27 RPS27L	6.20e-06	2	47	2	PF01667
Domain	Ribosomal_S27e	RPS27 RPS27L	6.20e-06	2	47	2	PD004466
Domain	RIBOSOMAL_S27E	RPS27 RPS27L	6.20e-06	2	47	2	PS01168
Domain	KRAB	ZNF560 ZNF432 ZNF778 ZFP69B ZNF614 ZNF443 ZNF284	2.91e-05	358	47	7	PS50805
Domain	KRAB	ZNF560 ZNF432 ZNF778 ZFP69B ZNF614 ZNF443 ZNF284	2.91e-05	358	47	7	PF01352
Domain	KRAB	ZNF560 ZNF432 ZNF778 ZFP69B ZNF614 ZNF443 ZNF284	3.54e-05	369	47	7	SM00349
Domain	KRAB	ZNF560 ZNF432 ZNF778 ZFP69B ZNF614 ZNF443 ZNF284	3.60e-05	370	47	7	IPR001909
Domain	FYrich_C	KMT2C KMT2D	6.17e-05	5	47	2	IPR003889
Domain	FYrich_N	KMT2C KMT2D	6.17e-05	5	47	2	IPR003888
Domain	FYRC	KMT2C KMT2D	6.17e-05	5	47	2	SM00542
Domain	FYRN	KMT2C KMT2D	6.17e-05	5	47	2	SM00541
Domain	FYRN	KMT2C KMT2D	6.17e-05	5	47	2	PF05964
Domain	FYRC	KMT2C KMT2D	6.17e-05	5	47	2	PF05965
Domain	FYRC	KMT2C KMT2D	6.17e-05	5	47	2	PS51543
Domain	FYRN	KMT2C KMT2D	6.17e-05	5	47	2	PS51542
Domain	ZF_RING_2	KMT2C KMT2D NFX1 PEX2 SIAH2 RNF217	9.72e-05	298	47	6	PS50089
Domain	Ribosomal_zn-bd	RPS27 RPS27L	2.21e-04	9	47	2	IPR011332
Domain	HMG_box	KMT2C KMT2D HMGXB3	3.20e-04	53	47	3	PF00505
Domain	HMG	KMT2C KMT2D HMGXB3	3.39e-04	54	47	3	SM00398
Domain	HMG_box_dom	KMT2C KMT2D HMGXB3	5.85e-04	65	47	3	IPR009071
Domain	Post-SET_dom	KMT2C KMT2D	7.27e-04	16	47	2	IPR003616
Domain	PostSET	KMT2C KMT2D	7.27e-04	16	47	2	SM00508
Domain	POST_SET	KMT2C KMT2D	7.27e-04	16	47	2	PS50868
Domain	ZF_RING_1	KMT2D NFX1 PEX2 SIAH2 RNF217	7.97e-04	291	47	5	PS00518
Domain	RING	KMT2C KMT2D NFX1 PEX2 SIAH2	9.83e-04	305	47	5	SM00184
Domain	Znf_PHD-finger	KMT2C KMT2D NFX1	1.03e-03	79	47	3	IPR019787
Domain	Znf_RING	KMT2C KMT2D NFX1 PEX2 SIAH2	1.32e-03	326	47	5	IPR001841
Domain	EPHD	KMT2C KMT2D	1.39e-03	22	47	2	PS51805
Domain	SET	KMT2C KMT2D	4.77e-03	41	47	2	PF00856
Domain	-	KMT2C KMT2D ZNF341 PEX2 SIAH2	5.25e-03	449	47	5	3.30.40.10
Domain	Znf_RING/FYVE/PHD	KMT2C KMT2D ZNF341 PEX2 SIAH2	5.76e-03	459	47	5	IPR013083
Domain	SET	KMT2C KMT2D	5.98e-03	46	47	2	SM00317
Domain	SET_dom	KMT2C KMT2D	7.03e-03	50	47	2	IPR001214
Domain	SET	KMT2C KMT2D	7.03e-03	50	47	2	PS50280
Domain	-	KMT2D HMGXB3	8.46e-03	55	47	2	1.10.30.10
Domain	PHD	KMT2C KMT2D	1.53e-02	75	47	2	PF00628
Pathway	BIOCARTA_CREM_PATHWAY	ADCY1 FHL5	8.93e-05	6	35	2	MM1538
Pathway	BIOCARTA_CREM_PATHWAY	ADCY1 FHL5	8.93e-05	6	35	2	M22012
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	ZNF462 KMT2C ZBTB2 KMT2D	4.47e-07	43	50	4	33472061
Pubmed	Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.	KMT2C KMT2D	2.03e-06	2	50	2	28483418
Pubmed	The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.	KMT2C KMT2D	2.03e-06	2	50	2	34156443
Pubmed	Neddylation modification of ribosomal protein RPS27L or RPS27 by MDM2 or NEDP1 regulates cancer cell survival.	RPS27 RPS27L	2.03e-06	2	50	2	32779270
Pubmed	Targeting ADT-Induced Activation of the E3 Ubiquitin Ligase Siah2 to Delay the Occurrence of Castration-Resistant Prostate Cancer.	SIAH2 AR	2.03e-06	2	50	2	33937036
Pubmed	KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.	KMT2C KMT2D	2.03e-06	2	50	2	31924266
Pubmed	Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.	KMT2C KMT2D	2.03e-06	2	50	2	27280393
Pubmed	Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.	KMT2C KMT2D	2.03e-06	2	50	2	36869380
Pubmed	Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.	KMT2C KMT2D	2.03e-06	2	50	2	28967912
Pubmed	Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.	KMT2C KMT2D	2.03e-06	2	50	2	25346535
Pubmed	Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.	KMT2C KMT2D	2.03e-06	2	50	2	36601880
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZNF462 KMT2D SALL1 NAV1 MECOM ZBTB11 RPS27L	2.20e-06	418	50	7	34709266
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	ZNF462 KMT2C ZBTB2 KMT2D SALL1	4.28e-06	167	50	5	20362541
Pubmed	Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics.	ZNF432 ZNF614	6.07e-06	3	50	2	24280104
Pubmed	Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates.	RPS27 RPS27L	6.07e-06	3	50	2	37306301
Pubmed	DHX15 promotes prostate cancer progression by stimulating Siah2-mediated ubiquitination of androgen receptor.	SIAH2 AR	6.07e-06	3	50	2	28991234
Pubmed	Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.	KMT2C KMT2D	6.07e-06	3	50	2	23932714
Pubmed	Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma.	KMT2C KMT2D	6.07e-06	3	50	2	22183980
Pubmed	The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity.	SIAH2 AR	6.07e-06	3	50	2	23518348
Pubmed	HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.	KMT2C KMT2D	6.07e-06	3	50	2	21683083
Pubmed	The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.	ZNF462 ACAN PEX2 ZNF76	9.21e-06	91	50	4	20546612
Pubmed	Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.	KMT2C KMT2D	1.21e-05	4	50	2	19221051
Pubmed	Cancer gene mutation frequencies for the U.S. population.	KMT2C KMT2D	1.21e-05	4	50	2	34645806
Pubmed	Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis.	ACAN NAV1	1.21e-05	4	50	2	38172636
Pubmed	Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator.	RPS27 RPS27L	1.21e-05	4	50	2	21170087
Pubmed	MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.	KMT2C KMT2D	1.21e-05	4	50	2	28398509
Pubmed	A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.	KMT2C KMT2D	1.21e-05	4	50	2	23129768
Pubmed	Sexually dimorphic expression of Mafb regulates masculinization of the embryonic urethral formation.	SALL1 AR	1.21e-05	4	50	2	25362053
Pubmed	The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.	KMT2C KMT2D	1.21e-05	4	50	2	24081332
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	ZNF462 KMT2C KMT2D GBE1 AR	1.63e-05	220	50	5	35785414
Pubmed	Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.	KMT2C KMT2D	2.02e-05	5	50	2	31127101
Pubmed	MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.	KMT2C KMT2D	2.02e-05	5	50	2	32601106
Pubmed	A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.	KMT2C KMT2D	2.02e-05	5	50	2	26744420
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KMT2C KMT2D ZNF341 NFX1 NAV1 SIAH2 HMGXB3 ZNF236 ZNF614	2.48e-05	1105	50	9	35748872
Pubmed	JS-K, a nitric oxide pro-drug, regulates growth and apoptosis through the ubiquitin-proteasome pathway in prostate cancer cells.	SIAH2 AR	3.03e-05	6	50	2	28549433
Pubmed	Targeting GRP78-dependent AR-V7 protein degradation overcomes castration-resistance in prostate cancer therapy.	SIAH2 AR	3.03e-05	6	50	2	32206096
Pubmed	Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.	KMT2C KMT2D	3.03e-05	6	50	2	17021013
Pubmed	Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.	KMT2C KMT2D	4.23e-05	7	50	2	30604749
Pubmed	Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.	KMT2C KMT2D	4.23e-05	7	50	2	36598580
Pubmed	The Steroidogenic Enzyme AKR1C3 Regulates Stability of the Ubiquitin Ligase Siah2 in Prostate Cancer Cells.	SIAH2 AR	4.23e-05	7	50	2	26160177
Pubmed	ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.	KMT2C KMT2D	4.23e-05	7	50	2	19556342
Pubmed	Nonmyocytic androgen receptor regulates the sexually dimorphic development of the embryonic bulbocavernosus muscle.	SALL1 AR	5.64e-05	8	50	2	24742196
Pubmed	Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.	KMT2C KMT2D	5.64e-05	8	50	2	21447625
Pubmed	The mutational landscape of lethal castration-resistant prostate cancer.	KMT2D AR	5.64e-05	8	50	2	22722839
Pubmed	H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development.	KMT2C KMT2D	5.64e-05	8	50	2	30335158
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2C KMT2D	5.64e-05	8	50	2	23130995
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	KMT2C KMT2D	5.64e-05	8	50	2	22266653
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	ZNF462 KMT2C ZBTB2 SALL1	5.91e-05	146	50	4	23892456
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2C KMT2D	7.25e-05	9	50	2	22665483
Pubmed	Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis.	RPS27 RPS27L	7.25e-05	9	50	2	25144937
Pubmed	MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.	KMT2C KMT2D	1.10e-04	11	50	2	37012455
Pubmed	Sall1 balances self-renewal and differentiation of renal progenitor cells.	SALL1 KIF26B MECOM	1.26e-04	67	50	3	24550112
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	KMT2C KMT2D	1.32e-04	12	50	2	27563068
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF432 ZNF778 ZBTB11 ZNF614	1.36e-04	181	50	4	37372979
Pubmed	Interaction network of human early embryonic transcription factors.	ZNF462 KMT2C KMT2D SALL1 MECOM	1.49e-04	351	50	5	38297188
Pubmed	Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.	KMT2C KMT2D	1.56e-04	13	50	2	21502505
Pubmed	Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.	KMT2C KMT2D	1.56e-04	13	50	2	17761849
Pubmed	Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.	KMT2C KMT2D	1.82e-04	14	50	2	12482968
Pubmed	A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc development.	ACAN SIM2	1.82e-04	14	50	2	28011632
Pubmed	Hundreds of variants clustered in genomic loci and biological pathways affect human height.	ZNF462 ZNF341 ACAN PEX2	1.91e-04	198	50	4	20881960
Pubmed	The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.	KMT2C KMT2D	2.10e-04	15	50	2	17925232
Pubmed	Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme.	SALL1 KIF26B	2.40e-04	16	50	2	20439720
Pubmed	H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.	KMT2C KMT2D	2.40e-04	16	50	2	24368734
Pubmed	Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.	FBXO3 SIAH2 RNF217	2.54e-04	85	50	3	19028597
Pubmed	MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.	KMT2C KMT2D	2.72e-04	17	50	2	26180087
Pubmed	Constitutive metanephric mesenchyme-specific expression of interferon-gamma causes renal dysplasia by regulating Sall1 expression.	SALL1 KIF26B	2.72e-04	17	50	2	29771971
Pubmed	A census of human transcription factors: function, expression and evolution.	KLF11 KMT2D SALL1 NFX1 ZNF76 ZNF236 AR	3.03e-04	908	50	7	19274049
Pubmed	PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.	KMT2C KMT2D	3.05e-04	18	50	2	17500065
Pubmed	Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.	KMT2C KMT2D	3.79e-04	20	50	2	29785026
Pubmed	A novel common variant in DCST2 is associated with length in early life and height in adulthood.	ACAN PEX2	3.79e-04	20	50	2	25281659
Pubmed	Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.	KMT2C KMT2D	3.79e-04	20	50	2	19047629
Pubmed	The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus.	KMT2C KMT2D	3.79e-04	20	50	2	33431871
Pubmed	Nonmuscle Myosin II Regulates the Morphogenesis of Metanephric Mesenchyme-Derived Immature Nephrons.	SALL1 KIF26B	4.18e-04	21	50	2	25168025
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2C KMT2D	4.18e-04	21	50	2	27626377
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	KMT2C KMT2D	4.59e-04	22	50	2	26886794
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ZNF462 KMT2C KLF11 NFX1 PEX2 HMGXB3	5.21e-04	709	50	6	22988430
Pubmed	A human MAP kinase interactome.	KMT2C KIF26B NAV1 RPS27 MAP3K4	6.59e-04	486	50	5	20936779
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	KMT2C ZBTB2 KMT2D	6.81e-04	119	50	3	23508102
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	KMT2C KMT2D	9.17e-04	31	50	2	20516061
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF462 KLF11 SALL1 ZNF76 HMGXB3 ZNF236	1.03e-03	808	50	6	20412781
Pubmed	MLL4 is required after implantation, whereas MLL3 becomes essential during late gestation.	KMT2C KMT2D	1.04e-03	33	50	2	32439762
Pubmed	Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases.	RPS27 MAP3K4	1.10e-03	34	50	2	16611982
Pubmed	A global genomic transcriptional code associated with CNS-expressed genes.	ZNF462 SALL1 FBXO3 PEX2	1.13e-03	318	50	4	16919269
Pubmed	Many sequence variants affecting diversity of adult human height.	ZNF462 PEX2 ZNF76	1.16e-03	143	50	3	18391951
Pubmed	Analysis of genes from inner ear developmental-stage cDNA subtraction reveals molecular regionalization of the otic capsule.	ACAN ZBTB11	1.17e-03	35	50	2	15031101
Pubmed	Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966.	ZNF462 ACAN	1.31e-03	37	50	2	19266077
Pubmed	Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.	KMT2D AR	1.38e-03	38	50	2	27930960
Interaction	GSC interactions	ZNF462 KMT2C KMT2D SALL1 MECOM	2.19e-06	87	49	5	int:GSC
Interaction	FEV interactions	ZNF462 KMT2C KMT2D SALL1 MECOM ZNF691	9.46e-06	203	49	6	int:FEV
Interaction	PHF21A interactions	KMT2D SALL1 NAV1 MECOM ZBTB11 AR RPS27L	1.81e-05	343	49	7	int:PHF21A
Interaction	ESRRB interactions	ZNF462 KMT2C KMT2D SALL1 RPS27 RPS27L	3.99e-05	262	49	6	int:ESRRB
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF462 KLF11 ZBTB2 SALL1 ZNF560 ZNF341 ZNF432 MECOM ZNF778 ZNF76 ZFP69B ZNF236 ZBTB11 ZNF614 ZNF443 ZNF691 ZNF284	2.84e-14	718	39	17	28
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2C KMT2D MECOM	5.30e-05	34	39	3	487
GeneFamily	PHD finger proteins	KMT2C KMT2D NFX1	9.58e-04	90	39	3	88
GeneFamily	S ribosomal proteins	RPS27 RPS27L	2.44e-03	34	39	2	728
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CFHR2 ACAN	6.71e-03	57	39	2	1179
Disease	Kleefstra syndrome 2 (implicated_via_orthology)	KMT2C KMT2D	2.81e-06	2	50	2	DOID:0080598 (implicated_via_orthology)
Disease	response to bronchodilator, response to corticosteroid	ZNF432 ZNF614	2.80e-05	5	50	2	GO_0031960, GO_0097366
Disease	aortic stenosis, aortic valve calcification	ACAN NAV1 MECOM	5.02e-05	42	50	3	EFO_0000266, EFO_0005239
Disease	interstitial lung disease	DPP9 NAV1 GBE1	2.03e-04	67	50	3	EFO_0004244
Disease	citrulline measurement	KIF26B MECOM	5.24e-04	20	50	2	EFO_0009777
Disease	Sezary Syndrome	KMT2C KMT2D	9.61e-04	27	50	2	C0036920

Protein segments in the cluster

Peptide	Gene	Start	Entry
SEKGHLYCPTCKVTV	ZNF385C	216	Q66K41
FSYKGKRCPTCHNII	NT5C3A	96	Q9H0P0
HTSRPKCNSYCFKIS	NWD2	1671	Q9ULI1
SSVKPFICEVCHKSY	MECOM	371	Q03112
GQCYHPYCVSIKITK	KMT2C	981	Q8NEZ4
FCPKKIYSVTCSGST	FNDC7	706	Q5VTL7
CVFCFGHAKLGKSYT	KIF26B	541	Q2KJY2
YKVCPHQVVCGSKYL	HMGXB3	1061	Q12766
KYCLPLTFCIHTGLS	FBXO3	191	Q9UK99
VYFTCPKCGTEVHSL	PEX2	276	P28328
IVEFVCKSGYHPTKS	CFHR2	236	P36980
VSAHVPNTYTCFCGK	NFX1	411	Q12986
HYGALTCGSCKVFFK	AR	571	P10275
FGKGHSRAKPTCTTY	MEAK7	376	Q6P9B6
PCNYHLPFTCKKGTV	ACAN	2431	P16112
FTNHTGSLCVCYSPK	GSAP	286	A4D1B5
CPYHFVCRGKVSVKG	ADCY1	1031	Q08828
HYCNFCKKVITSGGI	FHL5	161	Q5TD97
GKVASYKHFTCNVLP	GBE1	211	Q04446
ECKTGFCHLYKVTAV	DPP9	446	Q86TI2
CSFPGCRKTYFKSSH	KLF11	396	O14901
PKQHYCNTCGKTFSS	SALL1	1131	Q9NSC2
CKATPGTKIVGYSTH	MAP3K4	326	Q9Y6R4
CKYHKCPYIIGTTNQ	NAV1	1646	Q8NEY1
KYLRTHKPVFTLGCC	SLC6A5	596	Q9Y345
KCPGCYKITTVFSHA	RPS27L	36	Q71UM5
FAKCKAYPTSVCFSP	PPWD1	276	Q96BP3
HGAIISVTKSKCPSY	POP4	136	O95707
TCSGYKVIHCSGYLK	SIM2	176	Q14190
FPCKYATTGCSLTLH	SIAH2	136	O43255
SSTKPCPQCKHFTTF	RNF217	341	Q8TC41
QPLGCVKISCIFYHS	C12orf50	16	Q8NA57
RTGCFPFIKYHCSKA	C15orf61	81	A6NNL5
HVKPTSGNAFTICKY	VWDE	1286	Q8N2E2
PFKKYKCPFSTHTGC	ZNF341	646	Q9BYN7
VKPHACQVCGKTFIY	ZBTB11	676	O95625
IHTGIKPYTCSYCGK	ZNF778	386	Q96MU6
KPYRCTVCGKHFSRS	ZNF691	281	Q5VV52
VKPYICNVCSKTFSH	ZFP69B	416	Q9UJL9
HKCKVCGKAFVYPSV	ZNF443	421	Q9Y2A4
ICSECGKGFTTKHYV	ZNF432	346	O94892
VGYKCKFCVEVHPTL	ZNF462	1966	Q96JM2
TYSCPHCGKTFQKPS	ZNF236	196	Q9UL36
HMYIHTGKPFKCSTC	ZBTB2	381	Q8N680
TPFVCTECGKSYSHK	ZNF614	481	Q8N883
KCPGCYKITTVFSHA	RPS27	36	P42677
HCKPYTCSTCGKTYR	ZNF76	341	P36508
YKCKHCGKTFTVPSG	ZNF560	376	Q96MR9
PFKCYICGKSFHSRS	ZNF284	286	Q2VY69
SQCYHPYCVNSKITK	KMT2D	1401	O14686