Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnitric-oxide synthase activity

NOS1 NOS3

6.84e-053962GO:0004517
GeneOntologyMolecularFunctiontetrahydrobiopterin binding

NOS1 NOS3

1.36e-044962GO:0034617
GeneOntologyCellularComponentchromosomal region

SLF1 PHF6 CHD4 THOC3 DSN1 THOC5 SYCP2 KANSL1 NUP133 KNL1

2.17e-054219510GO:0098687
GeneOntologyCellularComponentnuclear protein-containing complex

DCAF1 RANBP1 HIF1A CDK12 NCKIPSD MECOM CHD4 PPARG THOC3 PRDM4 THOC5 HELB MSH6 KANSL1 PABPC3 NUP133 POLD3 ASCC3

4.21e-0513779518GO:0140513
GeneOntologyCellularComponentcondensed chromosome

SLF1 PHF6 DSN1 ADD3 SYCP2 KANSL1 NUP133 KNL1

7.94e-05307958GO:0000793
GeneOntologyCellularComponentcondensed chromosome, centromeric region

PHF6 DSN1 SYCP2 KANSL1 NUP133 KNL1

2.52e-04193956GO:0000779
GeneOntologyCellularComponentTHO complex

THOC3 THOC5

3.03e-046952GO:0000347
GeneOntologyCellularComponentTHO complex part of transcription export complex

THOC3 THOC5

3.03e-046952GO:0000445
GeneOntologyCellularComponentciliary transition fiber

FBF1 NIN

8.98e-0410952GO:0097539
GeneOntologyCellularComponentintermediate filament cytoskeleton

FBF1 NCKIPSD FAM83H DST MDN1 MACF1

1.28e-03263956GO:0045111
GeneOntologyCellularComponenttranscription export complex

THOC3 THOC5

1.31e-0312952GO:0000346
GeneOntologyCellularComponentkinetochore

PHF6 DSN1 KANSL1 NUP133 KNL1

1.42e-03181955GO:0000776
GeneOntologyCellularComponentneuron projection cytoplasm

RANBP1 HIF1A CHRNA2 DST

1.60e-03110954GO:0120111
GeneOntologyCellularComponentSNARE complex

STXBP5 NAPB VTI1B

1.62e-0351953GO:0031201
GeneOntologyCellularComponentchromosome, centromeric region

PHF6 DSN1 SYCP2 KANSL1 NUP133 KNL1

1.63e-03276956GO:0000775
MousePhenoeye inflammation

ASH1L ELP1 EDA ACE2 DST VPS13B

4.85e-0673846MP:0001851
MousePhenoabnormal second pharyngeal arch morphology

RANBP1 HIF1A ELP1 FGFR1

2.57e-0529844MP:0006338
MousePhenoabnormal cerebral blood flow rate

NOS1 NOS3

3.57e-052842MP:0031182
MousePhenoabsent second pharyngeal arch

HIF1A ELP1 FGFR1

4.43e-0512843MP:0006345
MousePhenoabsent limb buds

ELP1 MECOM FGFR1

5.73e-0513843MP:0004573
MousePhenoabnormal brain blood flow rate

NOS1 NOS3

1.07e-043842MP:0031179
DomainATPase_dyneun-rel_AAA

DNAH1 MDN1 DNAH11

4.18e-0514933IPR011704
DomainAAA_5

DNAH1 MDN1 DNAH11

4.18e-0514933PF07728
DomainCyt_c-like_dom

CYC1 DOCK2

7.33e-053932IPR009056
Domain-

NOS1 NOS3

7.33e-0539323.90.340.10
DomainNO_synthase

NOS1 NOS3

7.33e-053932PF02898
DomainSAPS

PPP6R1 PPP6R3

7.33e-053932IPR007587
DomainNOS_N

NOS1 NOS3

7.33e-053932IPR004030
DomainNOS

NOS1 NOS3

7.33e-053932PS60001
DomainSAPS

PPP6R1 PPP6R3

7.33e-053932PF04499
DomainNOS_euk

NOS1 NOS3

7.33e-053932IPR012144
Domain-

ZNF142 ZBTB38 HIVEP2 PEG3 MECOM ZNF407 ZNF362 ZNF236 PRDM4 ZIC1 ZBTB44 PRDM10

1.36e-0467993123.30.160.60
Domainzf-C2H2

ZNF142 ZBTB38 HIVEP2 PEG3 MECOM ZNF407 ZNF362 ZNF236 PRDM4 ZIC1 ZBTB44 PRDM10

1.65e-046939312PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF142 ZBTB38 HIVEP2 PEG3 MECOM ZNF407 ZNF362 ZNF236 PRDM4 ZIC1 ZBTB44 PRDM10

1.67e-046949312IPR013087
DomainSpectrin

KALRN DST MACF1

1.97e-0423933PF00435
Domain-

DST MACF1

3.63e-0469323.90.1290.10
DomainFAD_binding_1

NOS1 NOS3

3.63e-046932PF00667
DomainFAD-binding_1

NOS1 NOS3

3.63e-046932IPR003097
DomainGAR

DST MACF1

3.63e-046932PS51460
Domain-

DST MACF1

3.63e-0469323.30.920.20
Domain-

NOS1 NOS3

3.63e-0469321.20.990.10
DomainNADPH_Cyt_P450_Rdtase_dom3

NOS1 NOS3

3.63e-046932IPR023173
DomainGAS_dom

DST MACF1

3.63e-046932IPR003108
DomainGAS2

DST MACF1

3.63e-046932PF02187
DomainGAS2

DST MACF1

3.63e-046932SM00243
DomainSpectrin_repeat

KALRN DST MACF1

3.98e-0429933IPR002017
DomainZINC_FINGER_C2H2_2

ZNF142 ZBTB38 HIVEP2 PEG3 MECOM ZNF407 ZNF362 ZNF236 PRDM4 ZIC1 ZBTB44 PRDM10

4.56e-047759312PS50157
DomainZINC_FINGER_C2H2_1

ZNF142 ZBTB38 HIVEP2 PEG3 MECOM ZNF407 ZNF362 ZNF236 PRDM4 ZIC1 ZBTB44 PRDM10

4.67e-047779312PS00028
DomainPlectin_repeat

DST MACF1

5.07e-047932IPR001101
DomainPlectin

DST MACF1

5.07e-047932PF00681
DomainPLEC

DST MACF1

5.07e-047932SM00250
DomainSpectrin/alpha-actinin

KALRN DST MACF1

5.34e-0432933IPR018159
DomainSPEC

KALRN DST MACF1

5.34e-0432933SM00150
DomainZnf_C2H2-like

ZNF142 ZBTB38 HIVEP2 PEG3 MECOM ZNF407 ZNF362 ZNF236 PRDM4 ZIC1 ZBTB44 PRDM10

5.78e-047969312IPR015880
DomainZnf_C2H2

ZNF142 ZBTB38 HIVEP2 PEG3 MECOM ZNF407 ZNF362 ZNF236 PRDM4 ZIC1 ZBTB44 PRDM10

6.39e-048059312IPR007087
DomainZnF_C2H2

ZNF142 ZBTB38 HIVEP2 PEG3 MECOM ZNF407 ZNF362 ZNF236 PRDM4 ZIC1 ZBTB44 PRDM10

6.60e-048089312SM00355
DomainFLAVODOXIN_LIKE

NOS1 NOS3

6.74e-048932PS50902
DomainFlavodoxin/NO_synth

NOS1 NOS3

6.74e-048932IPR008254
DomainFlavdoxin-like

NOS1 NOS3

6.74e-048932IPR001094
DomainFlavodoxin_1

NOS1 NOS3

6.74e-048932PF00258
DomainFlavoprotein-like_dom

NOS1 NOS3

1.08e-0310932IPR029039
DomainFlavoprot_Pyr_Nucl_cyt_Rdtase

NOS1 NOS3

1.08e-0310932IPR001709
Domain-

NOS1 NOS3

1.08e-03109323.40.50.360
DomainOxRdtase_FAD/NAD-bd

NOS1 NOS3

1.57e-0312932IPR001433
DomainNAD_binding_1

NOS1 NOS3

1.57e-0312932PF00175
DomainSET_dom

ASH1L PRDM4 PRDM10

1.98e-0350933IPR001214
DomainSET

ASH1L PRDM4 PRDM10

1.98e-0350933PS50280
DomainDynein_heavy_chain_D4_dom

DNAH1 DNAH11

2.15e-0314932IPR024317
DomainDynein_HC_stalk

DNAH1 DNAH11

2.15e-0314932IPR024743
DomainDynein_heavy_dom-2

DNAH1 DNAH11

2.15e-0314932IPR013602
DomainDHC_N2

DNAH1 DNAH11

2.15e-0314932PF08393
DomainMT

DNAH1 DNAH11

2.15e-0314932PF12777
DomainAAA_8

DNAH1 DNAH11

2.15e-0314932PF12780
DomainDHC_fam

DNAH1 DNAH11

2.47e-0315932IPR026983
DomainDynein_heavy_dom

DNAH1 DNAH11

2.47e-0315932IPR004273
DomainDynein_heavy

DNAH1 DNAH11

2.47e-0315932PF03028
DomainFd_Rdtase_FAD-bd

NOS1 NOS3

3.97e-0319932IPR017927
DomainFAD_FR

NOS1 NOS3

3.97e-0319932PS51384
DomainRiboflavin_synthase-like_b-brl

NOS1 NOS3

3.97e-0319932IPR017938
DomainSH3

DOCK2 KALRN NCKIPSD DST MACF1

4.51e-03216935PS50002
DomainSH3_domain

DOCK2 KALRN NCKIPSD DST MACF1

4.87e-03220935IPR001452
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DCAF1 STXBP5 PEG3 PHF6 PPP6R1 URB2 ZDHHC17 KANSL1 COBL MACF1 BAIAP3 VPS13B USP33

1.22e-10407971312693553
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

DCAF1 FBF1 ASH1L MECOM CHD4 PPP6R1 ZNF362 ACY1 FAM83H MSH6 GTPBP2 MACF1 ASCC3 PCCA KNL1 NIN

7.87e-081116971631753913
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

PPP6R1 ADD3 HELB DST COBL MACF1 ASCC3 PPP6R3

1.36e-0720997836779422
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

DCAF1 DNAJC13 ELP1 PPP6R1 ZDHHC17 THOC5 ADD3 PAXBP1 MDN1 NUP133 EFR3B MACF1 SAMM50 ASCC3 VPS13B USP33 PPP6R3 NIN

1.39e-071487971833957083
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

AMPD1 ZBTB38 KALRN PEG3 ELP1 ZNF407 CHD4 ZBTB44 DST NUP133 MACF1

1.50e-07497971123414517
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

DCAF1 RANBP1 DNAJC13 PHF6 ELP1 CHD4 URB2 FAM83H MSH6 DST MDN1 KANSL1 NUP133 MACF1 SAMM50 POLD3 ASCC3

1.93e-071353971729467282
Pubmed

Differential HIF and NOS responses to acute anemia: defining organ-specific hemoglobin thresholds for tissue hypoxia.

HIF1A NOS1 NOS3

2.09e-07597324760996
Pubmed

Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia.

HIF1A NOS1 NOS3

2.09e-07597321976486
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

RANBP1 CDK12 PHF6 CHD4 PPP6R1 ADD3 MSH6 DST NUP133 MACF1 PCCA EPB41 KNL1 PPP6R3

3.26e-07934971433916271
Pubmed

The functional interactome landscape of the human histone deacetylase family.

CHD4 PPP6R1 ADD3 MSH6 PAXBP1 MDN1 NUP133 PPP6R3

1.57e-0628997823752268
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

DNAJC13 PHF6 ELP1 CHD4 ADD3 FAM83H MDN1 NUP133 SAMM50 ASCC3 PPP6R3

1.74e-06638971133239621
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

AMPD1 ZNF142 FBF1 PHF6 ELP1 URB2 DSN1 MDN1 ADAMTS6 KNL1 DNAH11

1.74e-06638971131182584
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

CYC1 RANBP1 ELP1 CHD4 PPP6R1 FCHO2 THOC3 MSH6 NUP133 SAMM50 PPP6R3

2.30e-06657971136180527
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

CYC1 SLF1 CDK12 POLH PHF6 CHD4 ZNF362 THOC3 PAXBP1 PABPC3 PCCA EPB41 KNL1

2.55e-06954971336373674
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

DNAJC13 POLH MECOM CHD4 PPP6R1 DST ASCC3 PCCA KNL1

2.70e-0641897934709266
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

DOCK2 DNAJC13 CDK12 ELP1 CHD4 MSH6 MDN1 KANSL1 MACF1 KNL1

5.44e-06582971020467437
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

CDK12 POLH FCHO2 DST PABPC3 MACF1 EPB41 KNL1 PPP6R3

7.20e-0647297938943005
Pubmed

Differential roles of neuronal and endothelial nitric oxide synthases during carrageenan-induced inflammatory hyperalgesia.

NOS1 NOS3

7.70e-06297215350652
Pubmed

Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling.

NOS1 NOS3

7.70e-06297224643800
Pubmed

Intron 4 polymorphism of the endothelial nitric oxide synthase gene is associated with the development of lupus nephritis.

NOS1 NOS3

7.70e-06297215119548
Pubmed

Modulation of the myogenic response in renal blood flow autoregulation by NO depends on endothelial nitric oxide synthase (eNOS), but not neuronal or inducible NOS.

NOS1 NOS3

7.70e-06297221825026
Pubmed

Chronic NOS inhibition actuates endothelial-mesenchymal transformation.

NOS1 NOS3

7.70e-06297216963618
Pubmed

Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice.

NOS1 NOS3

7.70e-0629728667023
Pubmed

nNOS and eNOS modulate cGMP formation and vascular response in contracting fast-twitch skeletal muscle.

NOS1 NOS3

7.70e-06297211015578
Pubmed

Renal cortical and medullary blood flow responses to L-NAME and ANG II in wild-type, nNOS null mutant, and eNOS null mutant mice.

NOS1 NOS3

7.70e-06297215961532
Pubmed

Acf7 (MACF) is an actin and microtubule linker protein whose expression predominates in neural, muscle, and lung development.

DST MACF1

7.70e-06297211002341
Pubmed

Contributions of endothelial and neuronal nitric oxide synthases to cerebrovascular responses to hyperoxia.

NOS1 NOS3

7.70e-06297214526232
Pubmed

Time-dependent PPARγ Modulation of HIF-1α Signaling in Hypoxic Pulmonary Artery Smooth Muscle Cells.

HIF1A PPARG

7.70e-06297227432037
Pubmed

Molecular regulation of PPARγ/RXRα signaling by the novel cofactor ZFP407.

ZNF407 PPARG

7.70e-06297238781157
Pubmed

Nitric oxide synthase polymorphisms and asthma phenotypes in Chinese children.

NOS1 NOS3

7.70e-06297216238787
Pubmed

Up-Regulation of Neuronal Nitric Oxide Synthase Expression by Cobalt Chloride Through a HIF-1α Mechanism in Neuroblastoma Cells.

HIF1A NOS1

7.70e-06297226458913
Pubmed

Hypoxia induces peroxisome proliferator-activated receptor γ expression via HIF-1-dependent mechanisms in HepG2 cell line.

HIF1A PPARG

7.70e-06297224374034
Pubmed

Sustained nitric oxide (NO)-releasing compound reverses dysregulated NO signal transduction in priapism.

NOS1 NOS3

7.70e-06297224076963
Pubmed

Normal development of the ipsilateral retinocollicular pathway and its disruption in double endothelial and neuronal nitric oxide synthase gene knockout mice.

NOS1 NOS3

7.70e-06297211027405
Pubmed

Neuronal nitric oxide synthase plays a key role in CNS demyelination.

NOS1 NOS3

7.70e-06297217151270
Pubmed

Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism.

NOS1 NOS3

7.70e-06297218305236
Pubmed

Regulation of renin gene expression in kidneys of eNOS- and nNOS-deficient mice.

NOS1 NOS3

7.70e-06297210764216
Pubmed

Repetitive hyperbaric oxygen exposures enhance sensitivity to convulsion by upregulation of eNOS and nNOS.

NOS1 NOS3

7.70e-06297218342297
Pubmed

Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity.

NOS1 NOS3

7.70e-0629727488039
Pubmed

The NOS3 G894T (Glu298Asp) polymorphism is a risk factor for frontotemporal lobar degeneration.

NOS1 NOS3

7.70e-06297219087148
Pubmed

Genetic analysis of NOS isoforms using nNOS and eNOS knockout animals.

NOS1 NOS3

7.70e-0629729932431
Pubmed

Rapid cerebral ischemic preconditioning in mice deficient in endothelial and neuronal nitric oxide synthases.

NOS1 NOS3

7.70e-06297212677017
Pubmed

Experience-dependent plasticity acts via GluR1 and a novel neuronal nitric oxide synthase-dependent synaptic mechanism in adult cortex.

NOS1 NOS3

7.70e-06297221813683
Pubmed

Expression, localization, and regulation of NOS in human mast cell lines: effects on leukotriene production.

NOS1 NOS3

7.70e-06297215044250
Pubmed

Cutaneous neuronal nitric oxide is specifically decreased in postural tachycardia syndrome.

NOS1 NOS3

7.70e-06297217660395
Pubmed

Endothelial Nitric Oxide Synthase Is Present in Dendritic Spines of Neurons in Primary Cultures.

NOS1 NOS3

7.70e-06297228725180
Pubmed

Reproductive function in female mice lacking the gene for endothelial nitric oxide synthase.

NOS1 NOS3

7.70e-06297210534440
Pubmed

Analysis of nitric oxide synthase gene polymorphisms in neonatal respiratory distress syndrome among the Chinese Han population.

NOS1 NOS3

7.70e-06297224602444
Pubmed

Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and age-related hypertrophic cardiac remodeling in mice.

NOS1 NOS3

7.70e-06297212788381
Pubmed

Angiotensin II response in afferent arterioles of mice lacking either the endothelial or neuronal isoform of nitric oxide synthase.

NOS1 NOS3

7.70e-06297217959704
Pubmed

Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo.

NOS1 NOS3

7.70e-0629729692709
Pubmed

Myocardial and lymphocytic expression of eNOS and nNOS before and after heart transplantation: relationship to clinical status.

NOS1 NOS3

7.70e-06297223770231
Pubmed

Nitric oxide synthase 1 is partly compensating for nitric oxide synthase 3 deficiency in nitric oxide synthase 3 knock-out mice and is elevated in murine and human cirrhosis.

NOS1 NOS3

7.70e-06297215287858
Pubmed

Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance.

NOS1 NOS3

7.70e-06297210905473
Pubmed

Nitric oxide synthase gene polymorphisms in children with minimal change nephrotic syndrome.

NOS1 NOS3

7.70e-06297219371282
Pubmed

Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms.

NOS1 NOS3

7.70e-06297211907582
Pubmed

Relative contribution of eNOS and nNOS to endothelium-dependent vasodilation in the mouse aorta.

NOS1 NOS3

7.70e-06297220624383
Pubmed

Neuronal NOS-cGMP-dependent ACh-induced relaxation in pial arterioles of endothelial NOS knockout mice.

NOS1 NOS3

7.70e-0629729486242
Pubmed

Refinement of the ipsilateral retinocollicular projection is disrupted in double endothelial and neuronal nitric oxide synthase gene knockout mice.

NOS1 NOS3

7.70e-06297210727738
Pubmed

Developmental changes in the response of murine cerebellar granule cells to nitric oxide.

NOS1 NOS3

7.70e-06297218406496
Pubmed

Diminished NO generation by injured endothelium and loss of macula densa nNOS may contribute to sustained acute kidney injury after ischemia-reperfusion.

NOS1 NOS3

7.70e-06297218971208
Pubmed

Does endothelial nitric oxide synthase gene variation play a role in the occurrence of hypertension in pregnancy?

NOS1 NOS3

7.70e-06297212908999
Pubmed

Role of nitric oxide synthase on brain GABA transaminase activity and GABA levels.

NOS1 NOS3

7.70e-06297231259693
Pubmed

Nitric oxide contributes to vascular smooth muscle relaxation in contracting fast-twitch muscles.

NOS1 NOS3

7.70e-06297211161004
Pubmed

Neuronal and endothelial nitric oxide synthase gene knockout mice.

NOS1 NOS3

7.70e-06297210559836
Pubmed

The cerebral metabolic consequences of nitric oxide synthase deficiency: glucose utilization in endothelial and neuronal nitric oxide synthase null mice.

NOS1 NOS3

7.70e-06297210027769
Pubmed

Priapism in a Fabry disease mouse model is associated with upregulated penile nNOS and eNOS expression.

NOS1 NOS3

7.70e-06297229110178
Pubmed

Assignment of the hypoxia-inducible factor 1alpha gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q.

HIF1A SERPINA6

7.70e-0629728786149
Pubmed

Carvedilol induces biased β1 adrenergic receptor-nitric oxide synthase 3-cyclic guanylyl monophosphate signalling to promote cardiac contractility.

NOS1 NOS3

7.70e-06297232956449
Pubmed

Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection.

NOS1 NOS3

7.70e-06297211904450
Pubmed

Modulation by NO of acetylcholine release in the ileum of wild-type and NOS gene knockout mice.

NOS1 NOS3

7.70e-06297212381527
Pubmed

Contribution of nNOS- and eNOS-derived NO to microvascular smooth muscle NO exposure.

NOS1 NOS3

7.70e-06297215033959
Pubmed

Infarct size and nitric oxide synthase in murine myocardium.

NOS1 NOS3

7.70e-06297210652188
Pubmed

Interleukin-15 Signaling in HIF-1α Regulation in Natural Killer Cells, Insights Through Mathematical Models.

IL15 HIF1A

7.70e-06297231681292
Pubmed

Downregulation of fatty acid oxidation by involvement of HIF-1α and PPARγ in human gastric adenocarcinoma and related clinical significance.

HIF1A PPARG

7.70e-06297233730333
Pubmed

Gastric stasis in neuronal nitric oxide synthase-deficient knockout mice.

NOS1 NOS3

7.70e-06297210982771
Pubmed

Effect of creatine supplementation on physical performance are related to the AMPD1 and PPARG genes polymorphisms in football players.

AMPD1 PPARG

7.70e-06297225665401
Pubmed

Telmisartan inhibits vasoconstriction via PPARγ-dependent expression and activation of endothelial nitric oxide synthase.

PPARG NOS3

7.70e-06297221156825
Pubmed

Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation.

NOS1 NOS3

7.70e-06297226152695
Pubmed

Peroxisome proliferator-activated receptor-gamma2-Pro12Ala and endothelial nitric oxide synthase-4a/bgene polymorphisms are associated with essential hypertension.

PPARG NOS3

7.70e-06297212923396
Pubmed

Alternatively spliced neuronal nitric oxide synthase mediates penile erection.

NOS1 NOS3

7.70e-06297216488973
Pubmed

The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach.

NOS1 NOS3

7.70e-06297219095954
Pubmed

Neuronal nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo.

NOS1 NOS3

7.70e-06297218048451
Pubmed

Immunocytochemical distribution of nitric oxide synthase in the human seminal vesicle: a light and electron microscopical study.

NOS1 NOS3

7.70e-06297212802542
Pubmed

Oxygen seizure latency and peroxynitrite formation in mice lacking neuronal or endothelial nitric oxide synthases.

NOS1 NOS3

7.70e-06297212781920
Pubmed

Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS.

NOS1 NOS3

7.70e-0629727518615
Pubmed

Proteolytic degradation of nitric oxide synthase isoforms by calpain is modulated by the expression levels of HSP90.

NOS1 NOS3

7.70e-06297217970747
Pubmed

Physician-diagnosed asthma and acute chest syndrome: associations with NOS polymorphisms.

NOS1 NOS3

7.70e-06297217351927
Pubmed

Establishment of patterned thalamocortical connections does not require nitric oxide synthase.

NOS1 NOS3

7.70e-0629729786989
Pubmed

Heme changes HIF-α, eNOS and nitrite production in HUVECs after simvastatin, HU, and ascorbic acid therapies.

HIF1A NOS3

7.70e-06297227089822
Pubmed

Endothelial nitric oxide synthase is predominantly involved in angiotensin II modulation of renal vascular resistance and norepinephrine release.

NOS1 NOS3

7.70e-06297218046021
Pubmed

Hypoxia-Inducible Factor 1α Stabilization Restores Epigenetic Control of Nitric Oxide Synthase 1 Expression and Reverses Gastroparesis in Female Diabetic Mice.

HIF1A NOS1

7.70e-06297237597632
Pubmed

Suppressive Role of PPARγ-Regulated Endothelial Nitric Oxide Synthase in Adipocyte Lipolysis.

PPARG NOS3

7.70e-06297226317347
Pubmed

Nitric oxide synthase gene polymorphisms in children with primary nocturnal enuresis: a preliminary study.

NOS1 NOS3

7.70e-06297217365914
Pubmed

NOS-I and -III gene variants are differentially associated with facets of suicidal behavior and aggression-related traits.

NOS1 NOS3

7.70e-06297217579350
Pubmed

Are myocardial eNOS and nNOS involved in the beta-adrenergic and muscarinic regulation of inotropy? A systematic investigation.

NOS1 NOS3

7.70e-06297216545353
Pubmed

Neuronal nitric oxide synthase in epidermis is involved in cutaneous circulatory response to mechanical stimulation.

NOS1 NOS3

7.70e-06297219940861
Pubmed

Displacement-encoded and manganese-enhanced cardiac MRI reveal that nNOS, not eNOS, plays a dominant role in modulating contraction and calcium influx in the mammalian heart.

NOS1 NOS3

7.70e-06297222058155
Pubmed

Neuronal nitric oxide synthase (NOS-I) knockout increases the survival rate of neural cells in the hippocampus independently of BDNF.

NOS1 NOS3

7.70e-06297217459722
Pubmed

Structures of human constitutive nitric oxide synthases.

NOS1 NOS3

7.70e-06297225286850
InteractionGSK3A interactions

PPP6R1 ZDHHC17 ADD3 HELB DST MDN1 NUP133 COBL MACF1 ASCC3 PPP6R3 NIN

2.09e-064649612int:GSK3A
InteractionHDAC1 interactions

DCAF1 HIF1A DNAJC13 POLH PHF6 MECOM CHD4 PPP6R1 PPARG PRDM4 THOC5 MSH6 DST POLD3 ASCC3 PCCA KNL1 PPP6R3

4.25e-0611089618int:HDAC1
InteractionNUP93 interactions

RANBP1 HIF1A CASP4 MECOM PPARG ACE2 NUP133 FGFR1 NIN

5.54e-06269969int:NUP93
InteractionNUP43 interactions

DCAF1 RANBP1 CDK12 POLH ASH1L CCDC168 HELB IWS1 PAXBP1 DST KANSL1 NUP133 KNL1

8.25e-066259613int:NUP43
InteractionHDAC11 interactions

PPP6R1 ADD3 MSH6 PAXBP1 MDN1 NUP133 PPP6R3

8.95e-06154967int:HDAC11
InteractionDTNBP1 interactions

DCAF1 KALRN FAM83H DST KANSL1 MACF1 VTI1B

1.25e-05162967int:DTNBP1
InteractionCIT interactions

CYC1 RANBP1 ZNF142 KALRN STXBP5 NCKIPSD ASH1L CHD4 ACY1 THOC3 EDA THOC5 IWS1 ACE2 MSH6 PAXBP1 PABPC3 NUP133 MACF1 NIN

1.33e-0514509620int:CIT
InteractionRCOR1 interactions

DNAJC13 POLH MECOM CHD4 PPP6R1 MSH6 DST ASCC3 PCCA KNL1 PPP6R3

2.32e-054949611int:RCOR1
InteractionUSP7 interactions

AMPD1 HIF1A ZBTB38 POLH FBF1 PEG3 MECOM PPARG EDA ACE2 ZBTB44 FAT2 DST MDN1 MACF1 POLD3 VPS13B PPP6R3

4.20e-0513139618int:USP7
InteractionSIRT7 interactions

DCAF1 POLH ELP1 CHD4 URB2 PPARG MSH6 DST MDN1 NUP133 MACF1 ASCC3 PPP6R3

5.11e-057449613int:SIRT7
InteractionEPB41L4A interactions

ADD3 DST MDN1 EFR3B MACF1 FGFR1

5.60e-05140966int:EPB41L4A
InteractionKRT78 interactions

CHD4 DSN1 FAM83H ACE2 KNL1

5.99e-0587965int:KRT78
Cytoband5q12

ADAMTS6 CD180

6.59e-0569725q12
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF142 ZBTB38 HIVEP2 PEG3 MECOM ZNF407 ZNF362 ZNF236 PRDM4 ZIC1 ZBTB44 PRDM10

1.32e-05718681228
GeneFamilyZinc fingers C2H2-type|PR/SET domain family

MECOM PRDM4 PRDM10

3.33e-05176831197
GeneFamilyProtein phosphatase 6 regulatory subunits

PPP6R1 PPP6R3

2.07e-046682699
GeneFamilyTHO complex

THOC3 THOC5

2.89e-047682770
GeneFamilyEF-hand domain containing|Plakins

DST MACF1

3.85e-048682939
GeneFamilyDyneins, axonemal

DNAH1 DNAH11

1.83e-0317682536
GeneFamilyPHD finger proteins

ASH1L PHF6 CHD4

4.73e-039068388
CoexpressionPYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP

SLF1 MECOM ZNF236 SYCP2 PAXBP1 PIGA POLD3 KNL1

6.67e-07195978M13736
CoexpressionGSE32901_TH1_VS_TH17_NEG_CD4_TCELL_UP

DCAF1 FCHO2 MMRN1 FAT2 FGFR1 POLD3

9.46e-06131976M8922
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

HIF1A DNAJC13 HIVEP2 MECOM ZDHHC17 MSH6 DST MDN1 NUP133 MACF1 ASCC3 PCCA VPS13B

1.63e-058569713M4500
CoexpressionLAKE_ADULT_KIDNEY_C11_THIN_ASCENDING_LIMB

HIF1A HIVEP2 MECOM FCHO2 ASCC3 VPS13B

4.00e-05169976M39230
CoexpressionMITSIADES_RESPONSE_TO_APLIDIN_DN

CHD4 EDA ADD3 MSH6 MDN1 MACF1 POLD3

4.09e-05250977M11318
ToppCellTCGA-Skin-Metastatic-Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

DOCK2 DCAF1 ZBTB38 PHF6 MECOM ADD3 MSH6 CD180

1.26e-08198978af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCellTCGA-Skin-Metastatic|TCGA-Skin / Sample_Type by Project: Shred V9

DOCK2 DCAF1 ZBTB38 PHF6 MECOM ADD3 MSH6 CD180

1.26e-08198978ad39cce004867f083f8da1954e0cf5a263815184
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

DOCK2 DCAF1 ZBTB38 PHF6 MECOM ADD3 MSH6 CD180

1.26e-0819897862cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ASH1L ZNF407 HELB KANSL1 MACF1 VPS13B EPB41

2.73e-07199977f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

STXBP5 MECOM ZNF407 KANSL1 PCCA VPS13B PPP6R3

2.73e-0719997794b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SLF1 ASH1L MECOM ADD3 DST MACF1 NIN

2.83e-07200977dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB38 PEG3 FCHO2 PAXBP1 MACF1 ASCC3

2.42e-06176976749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

CDK12 PHF6 ADD3 IWS1 PRDM10 VPS13B

3.33e-0618697603db813598b67b1e08f759758a1c2023396921fa
ToppCellCOVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

KALRN MECOM MMRN1 ADAMTS6 NOS1 NOS3

3.43e-061879762d20193a6cacdfa4877457c97b0077408942186c
ToppCelldroplet-Limb_Muscle-MUSCLE|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDK12 PEG3 ASH1L FCHO2 MACF1 ASCC3

4.24e-06194976e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PEG3 ASH1L CHD4 DST MACF1 ASCC3

4.37e-061959763e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PEG3 ASH1L CHD4 DST MACF1 ASCC3

4.37e-061959767796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellmild-CD4+_Tcm|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

HIVEP2 THOC3 ADD3 HELB MACF1 EPB41

4.91e-0619997606c8a0e39f7a33736548f04a5e2263334c8541cf
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Gen_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SLF1 MECOM ADD3 DST MACF1 NOS3

5.05e-06200976a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCellGlobus_pallidus|World / BrainAtlas - Mouse McCarroll V32

C4orf50 SYCP2 GTPBP2 BAIAP3 PPP6R3

8.34e-0612697544b63f945d5bedf1a2ca1810e7e100276ea9dd89
ToppCell356C-Fibroblasts-Fibroblast-D-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

DOCK2 NTS CCDC168 PPARG MMRN1

2.57e-05159975299e2162a82e31196d7f3a110c2db622349edfff
ToppCell356C-Fibroblasts-Fibroblast-D|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

DOCK2 NTS CCDC168 PPARG MMRN1

2.57e-051599750a3a363b30a8c741e1a3e2525725108d03c21776
ToppCelldroplet-Lung-nan-18m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL15 CASP4 ELP1 SYCP2 PPP1R42

2.98e-051649750e424a69999eee13d27c4ff4f4ba3df64d3c2bda
ToppCelldroplet-Lung-nan-18m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL15 CASP4 ELP1 SYCP2 PPP1R42

2.98e-05164975fe9ecdd7a6cbaf910f42654eba75f79bea740a00
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NR2E3 MMRN1 ADAMTS6 NOS1 NOS3

3.15e-05166975f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCellfacs-Lung-EPCAM-24m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NTS ACY1 DSN1 MMRN1 MSH6

3.25e-05167975961e722442d786ab15d1e490941d2be265a9057a
ToppCellfacs-Lung-EPCAM-24m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NTS ACY1 DSN1 MMRN1 MSH6

3.25e-051679753760efc35d4e7e9c2da1a20f9795ddea397e2206
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FBF1 SERPINA6 DNAH1 BAIAP3 DNAH11

3.34e-051689759a8709d34865cfa668d8f3335dc34fc86fc32482
ToppCellCV-Severe-7|Severe / Virus stimulation, Condition and Cluster

DNAJC13 KALRN ZNF407 DST KANSL1

4.28e-0517797582fdd6185b368f54f03de389427cbe3071d21a99
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB38 CDK12 ASH1L FCHO2 ASCC3

4.40e-0517897501dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KALRN ADD3 MMRN1 DST MACF1

4.40e-05178975ad3de3e03a401dac64431a541899445262246347
ToppCellTCGA-Mesothelium-Primary_Tumor-Mesothelioma-Epitheliod|TCGA-Mesothelium / Sample_Type by Project: Shred V9

CASP4 EDA FAM83H ZBTB44 COBL

4.89e-05182975bb1f815718397de96682697fcbd6014a992a28f7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KCNH7 MECOM DST PCCA NOS1

5.56e-0518797577886f99c229610abd28c4c370d2c7d1536c9782
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KCNH7 MECOM DST COBL PCCA

5.56e-05187975f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCellCOVID-19-lung-Vein_EC|lung / Disease (COVID-19 only), tissue and cell type

KALRN MMRN1 ADAMTS6 NOS1 NOS3

5.70e-05188975d582b76fc2faac526c9bf97503041129e1a6a211
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KCNH7 MECOM DST COBL PCCA

5.85e-05189975e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCellPBMC-Severe-cDC_12|Severe / Compartment, Disease Groups and Clusters

SLF1 DSN1 MSH6 POLD3 KNL1

5.99e-0519097584ee185939bdefb10705b621a70da27701eadcee
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CHD4 ADD3 DST MACF1 NIN

5.99e-05190975d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

STXBP5 ERI2 THOC5 KANSL1 KNL1

5.99e-051909753f0c7d130f66faea778fe567604edf1b4cdf85b3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

HIF1A HIVEP2 COBL MACF1 FGFR1

6.30e-051929758b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCellLPS-IL1RA-Endothelial-Endothelial-Vein|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KALRN MMRN1 ADAMTS6 NOS1 NOS3

6.30e-05192975717f3d3bbee4d0f64ba1341ee2b00a407ba1e0f3
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

URB2 DSN1 PAXBP1 CCDC87 POLD3

6.30e-05192975d6f656be2698bd215717d35f4e7ab727c08c61e0
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

STXBP5 ERI2 THOC5 KANSL1 KNL1

6.30e-05192975c09dcc73ff9c3855a0f3d7bfa0d5c99c09a117f2
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLF1 MECOM DST ADAMTS6 MACF1

6.61e-051949750b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCellEndothelial-endothelial_cell_of_vein|World / Lineage, Cell type, age group and donor

KALRN MMRN1 ADAMTS6 NOS1 NOS3

6.61e-051949753cbd9622a68e89add90e589867d88c83c5a33476
ToppCellCOPD-Endothelial-Lymphatic|Endothelial / Disease state, Lineage and Cell class

KALRN NTS ADD3 MMRN1 DST

6.78e-05195975e91ce548ae7224661ee5d2f2639794a5f69798ee
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

MECOM ZNF407 KANSL1 PCCA VPS13B

6.94e-05196975ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCellControl-Endothelial-Lymphatic|Endothelial / Disease state, Lineage and Cell class

KALRN NTS ADD3 MMRN1 DST

6.94e-05196975e0cf617b0f5d9c3c19574f587a3d0ccbf93d8ca4
ToppCell356C-Endothelial_cells-Endothelial-F_(Lymphatics)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

KALRN NTS ZDHHC17 ADD3 MMRN1

6.94e-05196975b04ca69b0ed44e09c989b575f747e1e819cd8008
ToppCell356C-Endothelial_cells-Endothelial-F_(Lymphatics)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

KALRN NTS ZDHHC17 ADD3 MMRN1

6.94e-05196975a31e227de2dc077b81881295b012d22fedbd65ed
ToppCell5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DCAF1 NTS ZNF407 PRDM4 MMRN1

7.11e-05197975789c97ca9d1e28df3353140046047f11fbccc1d0
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

MECOM ZNF407 KANSL1 PCCA VPS13B

7.28e-051989751996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KALRN MMRN1 ADAMTS6 NOS1 NOS3

7.46e-051999753a4deea6e11a0555d27497b7c9983350797aac69
ToppCellmild-CD4+_T_naive|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

THOC3 EDA ADD3 HELB EPB41

7.46e-051999753e4baaf4ee23f257d821194468102c00a8ad2f21
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Vein|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

HIF1A MMRN1 DST ADAMTS6 NOS3

7.64e-052009757eb366b2c5394af7c77650bde6261e7dac67154e
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ASH1L PAXBP1 KANSL1 MACF1 EPB41

7.64e-0520097512f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SLF1 MECOM ADD3 DST NOS3

7.64e-05200975b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCellClub_cells-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

NR2E3 NTS ACE2 KNL1

1.38e-041209747f85208f0455f3e634f8e7e81beea60b4ef1d2a5
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

ASH1L MSH6 PAXBP1 DST MACF1

1.10e-0550645GAVISH_3CA_MALIGNANT_METAPROGRAM_4_CHROMATIN
Drugudenafil

HIF1A NOS1 NOS3

4.13e-068973ctd:C419664
DrugCAS 76095-16-4

PPARG EDA ACE2 DST NOS1 NOS3

1.67e-05126976CID000003222
DrugL-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide

NOS1 NOS3

1.80e-052972DB01821
DrugS-Ethyl-N-Phenyl-Isothiourea

NOS1 NOS3

1.80e-052972DB03707
DrugN-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE

NOS1 NOS3

1.80e-052972DB08018
DrugN-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine

NOS1 NOS3

1.80e-052972DB08019
DrugL-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide

NOS1 NOS3

1.80e-052972DB02077
DrugN-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine

NOS1 NOS3

1.80e-052972DB02027
DrugNitroarginine

NOS1 NOS3

1.80e-052972DB04223
DrugTrimethoprim [738-70-5]; Down 200; 13.8uM; PC3; HT_HG-U133A

IL15 NR2E3 INPP5B EDA SYCP2 COBL BAIAP3

2.32e-051999773678_DN
DrugAMT hydrochloride

PPARG EDA NOS3

2.64e-0514973CID000001534
Diseaselimb ischemia (biomarker_via_orthology)

HIF1A FGFR1 NOS3

3.34e-083963DOID:0050852 (biomarker_via_orthology)
DiseaseMalignant neoplasm of breast

RANBP1 HIF1A KALRN POLH ELP1 C4orf50 MECOM ACY1 THOC5 MSH6 NUP133 MACF1 FGFR1 NOS3 VPS13B

1.96e-0610749615C0006142
DiseaseIntellectual Disability

ZNF142 HIVEP2 ASH1L ACY1 ACE2 GTPBP2 KANSL1 MACF1 ASCC3

1.57e-05447969C3714756
DiseaseIntestinal Perforation

NOS1 NOS3

3.14e-053962C0021845
DiseaseX-24309 measurement

DNAJC13 FBF1 CHRNA2

3.65e-0520963EFO_0800872
Diseasealcoholic cardiomyopathy (biomarker_via_orthology)

PPARG NOS1

6.26e-054962DOID:12935 (biomarker_via_orthology)
Diseaseobsolete_red blood cell distribution width

DNAJC13 KALRN CDK12 INPP5B MECOM ZNF407 CHD4 PPARG FCHO2 THOC3 KANSL1 FGFR1 KNL1 PPP6R3

1.15e-0413479614EFO_0005192
DiseaseMental Depression

HIF1A NTS SERPINA6 CHRNA2 FGFR1 NOS3

1.86e-04254966C0011570
DiseaseThyroid Gland Follicular Adenoma

HIF1A PPARG MSH6

2.03e-0435963C0151468
Diseaseposterior thigh muscle fat infiltration measurement

PPARG CCDC87 POLD3

2.03e-0435963EFO_0020934
Diseasebrain ischemia (implicated_via_orthology)

HIF1A NOS1 NOS3

2.03e-0435963DOID:2316 (implicated_via_orthology)
Diseasemyeloid neoplasm (is_implicated_in)

MECOM FGFR1

2.18e-047962DOID:0070004 (is_implicated_in)
DiseaseThyroid Neoplasm

HIF1A PPARG MSH6

2.39e-0437963C0040136
Diseasemean corpuscular hemoglobin concentration

CYC1 DNAJC13 KALRN CDK12 MECOM PPP6R1 URB2 FCHO2 MACF1 VPS13B EPB41 PPP6R3

2.47e-0411059612EFO_0004528
DiseaseNodular glomerulosclerosis

PPARG ACE2 NOS3

3.25e-0441963C0017667
DiseaseDepressive disorder

NTS SERPINA6 CHRNA2 FGFR1 NOS1 NOS3

3.71e-04289966C0011581
Diseasepancreatitis (implicated_via_orthology)

IL15 PPARG

3.72e-049962DOID:4989 (implicated_via_orthology)
Diseasebladder neck obstruction (biomarker_via_orthology)

HIF1A NOS3

3.72e-049962DOID:13948 (biomarker_via_orthology)
DiseaseDiabetic Nephropathy

PPARG ACE2 NOS3

4.01e-0444963C0011881
DiseaseThyroid carcinoma

HIF1A PPARG MSH6

4.01e-0444963C0549473
Diseasediabetic retinopathy (biomarker_via_orthology)

HIF1A NOS1 NOS3

4.29e-0445963DOID:8947 (biomarker_via_orthology)
Diseasehepatocellular carcinoma (is_marker_for)

HIF1A CDK12 PHF6 CHD4 PPARG DSN1

4.61e-04301966DOID:684 (is_marker_for)
DiseaseColorectal Carcinoma

AMPD1 KALRN PEG3 PPARG ERI2 EDA MSH6 C2CD6 POLD3

4.77e-04702969C0009402
Diseasetotal blood protein measurement

DNAJC13 ZBTB38 PPARG DNAH1 MACF1 FGFR1 ASCC3

6.71e-04449967EFO_0004536
DiseaseOligodontia

EDA FGFR1

6.77e-0412962C4082304
DiseaseMyeloproliferative disease

MECOM FGFR1

6.77e-0412962C0027022
Diseasecardiomyopathy (biomarker_via_orthology)

NOS1 NOS3

7.98e-0413962DOID:0050700 (biomarker_via_orthology)
Diseasehypertension (implicated_via_orthology)

PPARG ADD3 NOS1 NOS3

8.25e-04128964DOID:10763 (implicated_via_orthology)
Diseasehypertension (biomarker_via_orthology)

HIF1A PPARG ACE2 NOS1 NOS3

8.93e-04227965DOID:10763 (biomarker_via_orthology)
DiseaseHypodontia

EDA FGFR1

9.29e-0414962C0020608
Diseaseprostate carcinoma, type 2 diabetes mellitus

ZBTB38 ZNF236 KNL1

9.51e-0459963EFO_0001663, MONDO_0005148
Diseaseovarian neoplasm

CDK12 MECOM MSH6 KANSL1

9.78e-04134964C0919267
DiseasePROSTATE CANCER, HEREDITARY, 1

DOCK2 MECOM KNL1

9.98e-0460963C4722327
Diseaseacute kidney failure (biomarker_via_orthology)

HIF1A NOS1 NOS3

1.05e-0361963DOID:3021 (biomarker_via_orthology)
DiseaseMalignant neoplasm of ovary

CDK12 MECOM MSH6 KANSL1

1.06e-03137964C1140680
Diseasehepatic encephalopathy (biomarker_via_orthology)

HIF1A NOS1

1.07e-0315962DOID:13413 (biomarker_via_orthology)
Diseasetransient cerebral ischemia (implicated_via_orthology)

PPARG NOS1 NOS3

1.20e-0364963DOID:224 (implicated_via_orthology)
DiseaseSynostotic Posterior Plagiocephaly

ZIC1 FGFR1

1.22e-0316962C1833340
DiseaseCraniosynostosis, Type 1

ZIC1 FGFR1

1.22e-0316962C4551902
DiseaseAcrocephaly

ZIC1 FGFR1

1.22e-0316962C0030044
Diseasegliosarcoma

PPARG FGFR1

1.22e-0316962C0206726
DiseaseTrigonocephaly

ZIC1 FGFR1

1.22e-0316962C0265535
DiseaseScaphycephaly

ZIC1 FGFR1

1.22e-0316962C0265534
Diseasediabetic retinopathy (implicated_via_orthology)

HIF1A NOS3

1.22e-0316962DOID:8947 (implicated_via_orthology)
DiseaseSynostotic Anterior Plagiocephaly

ZIC1 FGFR1

1.22e-0316962C2931150
DiseaseMetopic synostosis

ZIC1 FGFR1

1.22e-0316962C1860819
Diseasestroke

KALRN FAT2 NOS3 NIN

1.28e-03144964EFO_0000712
Diseasemagnesium measurement

MECOM CCDC168 ZNF362

1.32e-0366963EFO_0004845
Diseaseobesity (biomarker_via_orthology)

PPARG FGFR1 NOS1 NOS3

1.38e-03147964DOID:9970 (biomarker_via_orthology)
DiseaseBrachycephaly

ZIC1 FGFR1

1.38e-0317962C0221356
DiseaseProstate cancer, familial

DOCK2 MECOM KNL1

1.50e-0369963C2931456
DiseaseAlzheimer's disease (is_marker_for)

HIF1A NAPB FGFR1 NOS1 NOS3

1.55e-03257965DOID:10652 (is_marker_for)
Diseasehematocrit

NR2E3 DNAJC13 ZBTB38 HIVEP2 KALRN ASH1L PHF6 MECOM PPARG POLD3

1.68e-0310119610EFO_0004348
Diseaseportal hypertension (implicated_via_orthology)

NOS1 NOS3

1.73e-0319962DOID:10762 (implicated_via_orthology)
Diseasepolycystic kidney disease (biomarker_via_orthology)

HIF1A NOS3

1.73e-0319962DOID:0080322 (biomarker_via_orthology)
Diseasefactor VIII measurement, Ischemic stroke

STXBP5 FCHO2

1.73e-0319962EFO_0004630, HP_0002140
Diseasetransient cerebral ischemia (biomarker_via_orthology)

HIF1A PPARG FGFR1 NOS3

1.75e-03157964DOID:224 (biomarker_via_orthology)
Diseaseasthma (is_implicated_in)

IL15 ELP1 NOS1 NOS3

1.75e-03157964DOID:2841 (is_implicated_in)
Diseasewellbeing measurement, alcohol consumption measurement

CDK12 STXBP5 DST

1.83e-0374963EFO_0007869, EFO_0007878
Diseasemyocardial infarction (biomarker_via_orthology)

RANBP1 HIF1A ACE2 NOS3

1.88e-03160964DOID:5844 (biomarker_via_orthology)
DiseaseCraniosynostosis

ZIC1 FGFR1

1.92e-0320962C0010278
Diseaseepilepsy (implicated_via_orthology)

KCNH7 KALRN NOS1 NOS3

2.01e-03163964DOID:1826 (implicated_via_orthology)
Diseasered blood cell density measurement

KALRN CDK12 MECOM CHD4 PPARG FCHO2 DST KANSL1 VPS13B

2.30e-03880969EFO_0007978
Diseaseotitis media (implicated_via_orthology)

MECOM FGFR1

2.32e-0322962DOID:10754 (implicated_via_orthology)
Diseaseimpotence (biomarker_via_orthology)

NOS1 NOS3

2.32e-0322962DOID:1875 (biomarker_via_orthology)
Diseaseacute myeloid leukemia (is_implicated_in)

PHF6 FGFR1 NOS3

2.63e-0384963DOID:9119 (is_implicated_in)
DiseaseGiant Cell Glioblastoma

HIF1A PPARG FGFR1

2.63e-0384963C0334588
DiseaseDyslipidemias

PPARG DNAH11

2.76e-0324962C0242339
DiseaseDyslipoproteinemias

PPARG DNAH11

2.76e-0324962C0598784
DiseaseCerebral Astrocytoma

HIF1A FGFR1

2.99e-0325962C0750935
DiseaseIntracranial Astrocytoma

HIF1A FGFR1

2.99e-0325962C0750936
DiseaseAstrocytoma

HIF1A FGFR1

2.99e-0325962C0004114
DiseaseGrade I Astrocytoma

HIF1A FGFR1

2.99e-0325962C1704230
DiseaseSubependymal Giant Cell Astrocytoma

HIF1A FGFR1

2.99e-0325962C0205768
DiseaseMixed oligoastrocytoma

HIF1A FGFR1

2.99e-0325962C0547065
DiseasePilocytic Astrocytoma

HIF1A FGFR1

2.99e-0325962C0334583
DiseaseJuvenile Pilocytic Astrocytoma

HIF1A FGFR1

2.99e-0325962C0280783
DiseaseDiffuse Astrocytoma

HIF1A FGFR1

2.99e-0325962C0280785
DiseaseChildhood Cerebral Astrocytoma

HIF1A FGFR1

2.99e-0325962C0338070
DiseaseFEV change measurement, response to zileuton

C4orf50 CHRNA2

2.99e-0325962EFO_0005921, EFO_0007676
DiseaseGemistocytic astrocytoma

HIF1A FGFR1

3.24e-0326962C0334581
DiseaseProtoplasmic astrocytoma

HIF1A FGFR1

3.24e-0326962C0334580
DiseaseFibrillary Astrocytoma

HIF1A FGFR1

3.24e-0326962C0334582

Protein segments in the cluster

PeptideGeneStartEntry
LHPKKDSVFTSMFHS

URB2

1191

Q14146
TVHHVSDLEMSSTLD

ERI2

386

A8K979
HHASISELKKNFMES

EPB41

681

P11171
HKSFATHKLSSSMCV

ASH1L

801

Q9NR48
SGLVHFSEDHIKSFM

CDK12

826

Q9NYV4
AHTVTAHLTSKMVGD

BAIAP3

856

O94812
HIHTLATAAVSSMKC

ADD3

231

Q9UEY8
EHKSSDSTFLVLMSH

CASP4

196

P49662
DSKAEENGSHSFMHS

DNM1P46

31

Q6ZS02
SSSKMITFIDLAGHH

GTPBP2

251

Q9BX10
NSHHTMASLDELKVS

FCHO2

366

Q0JRZ9
VHKDSISLFMAHVHT

DNAH11

3036

Q96DT5
AVTHMTKAHLFSTGT

CHRNA2

156

Q15822
SVDDESKHSGHMFSS

AMPD1

511

P23109
MALHSAVSASDLELH

CYC1

76

P08574
KELMSHVSSDHLHFD

CCDC87

496

Q9NVE4
KMSHVDLSHNSLTCD

CD180

521

Q99467
ILSLIMASSEFHSDH

ADAMTS6

11

Q9UKP5
MAAAKDTHEDHDTST

RANBP1

1

P43487
HHFMASLITAETCAK

NR2E3

171

Q9Y5X4
EDSADKVMSHSGDSH

RABEPK

326

Q7Z6M1
NDSFHSDSHMDRKKF

IWS1

346

Q96ST2
MLSLSDKESLHSTSH

MECOM

1191

Q03112
HAQMVVDELFSSHSD

NUP133

536

Q8WUM0
DMEISFHLDSGHKTS

DCAF1

236

Q9Y4B6
SELHTSLHSSMVGAD

MDN1

3416

Q9NU22
SMHIDATLYTESDVH

IL15

66

P40933
DSSKHSDDSVAMKHF

KCNH7

186

Q9NS40
IHHKCTSDMETILTF

MMRN1

761

Q13201
SEMSKLAVSHEEFLH

DST

3506

Q03001
ALDSDHLTKTHHDMF

HIF1A

281

Q16665
DKFEDLHDMTSFTHL

C2CD6

531

Q53TS8
SIITHSAKEMEHSVG

FAT2

3701

Q9NYQ8
FSEMCHSSHDDLEIK

EFR3B

146

Q9Y2G0
DMSVSFHTHTKELWT

KALRN

641

O60229
HSSERSEVLKHHTDM

KANSL1

791

Q7Z3B3
SEVLKHHTDMSSSSY

KANSL1

796

Q7Z3B3
HKDSMDELFSHRSEI

MACF1

1851

O94854
MKNHDTAISSHTVKS

KNL1

736

Q8NG31
SVIHHLTAASSEMDE

ELP1

526

O95163
SSTSLESHMKLHSDQ

PRDM10

571

Q9NQV6
SVRALDHAMSVASDH

PAXBP1

891

Q9Y5B6
AIHSDVDASSVHVKM

PCCA

91

P05165
ETASILMHATAHSLV

MSH6

1196

P52701
SSTAFSEHLKTHASM

PEG3

1516

Q9GZU2
HTKDAEHALDTMNFD

PABPC3

61

Q9H361
HHSATESFIKHMENE

NOS1

656

P29475
TIVDHHAATASFMKH

NOS3

416

P29474
DFLTNMHTSKISKAH

NTS

36

P30990
MSLFHSSLSKYSHLE

DNAH1

526

Q9P2D7
HADISINMSKHTTFF

EDA

366

Q92838
ETSHHLDVKSEMTAA

C4orf50

136

Q6ZRC1
IHQMEKFSSSLHELS

FBF1

741

Q8TES7
KHEFMSDTNLSEHAA

DOCK2

1726

Q92608
SDFHSQMAVHKLAKS

FGFR1

406

P11362
DTSLHSALMEAIHSA

COBL

1106

O75128
VMSKTHDHQLESSLS

DSN1

16

Q9H410
CTKVTMDDFLTAHHE

ACE2

361

Q9BYF1
HTFMAITHAAKVESE

DNAJC13

1726

O75165
LSYQSHMALKTSDHK

INPP5B

616

P32019
MHQDKETSDAFHSAT

CCDC168

831

Q8NDH2
HLEMDAFKRHSFATE

FAM83H

401

Q6ZRV2
ECLAESHQHLSKESM

CHD4

1826

Q14839
GHSLKSSLSHAMVID

SAMM50

251

Q9Y512
HLHQLFAKSDTSLEM

SERPINA6

111

P08185
TLSNHMSFHAASESL

HELB

321

Q8NG08
CDKSFTQKAHLESHM

PRDM4

651

Q9UKN5
SHLHMEAPFETKVST

RGSL1

326

A5PLK6
LKSLMASEVDDHHAA

NIN

396

Q8N4C6
DASNSLISNFKTMHH

PPP1R42

261

Q7Z4L9
SSVDLSVMEDHSHSF

PPARG

46

P37231
DAHKMSHDAFTVIKN

POLH

391

Q9Y253
SSKKFEQSHLHMSSE

POLD3

151

Q15054
LSSAESFSKHAHEIM

STXBP5

1126

Q5T5C0
VMTSSTSDHHLDAAA

NCKIPSD

116

Q9NZQ3
HASRFMEDTAAEKLH

ACY1

206

Q03154
KDHVFSSMVESELHA

ASCC3

2006

Q8N3C0
FSAMAHDALFHAKTM

PIGA

131

P37287
AHHKCMLFSSALVSS

PHF6

41

Q8IWS0
EDADHHIHKMSESVS

SYCP2

1321

Q9BX26
HDGKMLASASEDHFI

THOC3

276

Q96J01
FTHSSSSHSQEMLGK

ZBTB44

6

Q8NCP5
LHMQLQSKHDSATSF

NAPB

71

Q9H115
MACKSHKETTSVHTD

SLF1

991

Q9BQI6
MFWKFDLHTSSHLDT

PPP6R1

1

Q9UPN7
TVQFLSKSFFDHSMH

ZDHHC17

341

Q8IUH5
SCNKTFSTMHELVTH

ZIC1

241

Q15915
KNAHSLAHSEETSAM

VPS13B

2071

Q7Z7G8
FFTKSEMQIHSKSHT

ZNF362

236

Q5T0B9
FSSAAVLMHHSKEVH

ZNF236

1666

Q9UL36
FDSSTLLSAHMQLHK

ZBTB38

351

Q8NAP3
LFATAEAMEAHHKSH

ZNF142

326

P52746
SSCSDLEKHAESHMQ

ZNF407

196

Q9C0G0
VIADHSLSASHMETT

THOC5

461

Q13769
KAAEKHSMSSISTDH

HIVEP2

1881

P31629
MFWKFDLHSSSHIDT

PPP6R3

1

Q5H9R7
MASSAASSEHFEKLH

VTI1B

1

Q9UEU0
HELMFSTKISTHVSF

USP33

621

Q8TEY7