Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionandrosterone dehydrogenase (B-specific) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.33e-0941224GO:0047042
GeneOntologyMolecularFunctionketoreductase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.33e-0941224GO:0045703
GeneOntologyMolecularFunctionchlordecone reductase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.33e-0941224GO:0047743
GeneOntologyMolecularFunctiontrans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.60e-0951224GO:0047115
GeneOntologyMolecularFunction15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.60e-0951224GO:0047020
GeneOntologyMolecularFunction17-beta-ketosteroid reductase (NADPH) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.60e-0951224GO:0072555
GeneOntologyMolecularFunction17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.60e-0951224GO:0047006
GeneOntologyMolecularFunctionlithocholic acid binding

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.60e-0951224GO:1902121
GeneOntologyMolecularFunctionketosteroid monooxygenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.60e-0951224GO:0047086
GeneOntologyMolecularFunctionDelta4-3-oxosteroid 5beta-reductase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.60e-0951224GO:0047787
GeneOntologyMolecularFunctiongeranylgeranyl reductase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.97e-0861224GO:0045550
GeneOntologyMolecularFunction17-beta-hydroxysteroid dehydrogenase (NADP+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.58e-0871224GO:0072582
GeneOntologyMolecularFunction5alpha-androstane-3beta,17beta-diol dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.11e-0881224GO:0047024
GeneOntologyMolecularFunctionandrosterone dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.11e-0881224GO:0047023
GeneOntologyMolecularFunctionenone reductase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.11e-0881224GO:0035671
GeneOntologyMolecularFunctionandrostan-3-alpha,17-beta-diol dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.63e-0791224GO:0047044
GeneOntologyMolecularFunctionNADP+ binding

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.63e-0791224GO:0070401
GeneOntologyMolecularFunctiontestosterone 17-beta-dehydrogenase (NADP+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.71e-07101224GO:0047045
GeneOntologyMolecularFunctionbile acid binding

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.71e-07101224GO:0032052
GeneOntologyMolecularFunctionNADPH binding

AKR1C4 LBR AKR1C1 AKR1C2 AKR1C3

4.65e-07261225GO:0070402
GeneOntologyMolecularFunctionaldose reductase (NADPH) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.27e-06141224GO:0004032
GeneOntologyMolecularFunctionretinal dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.27e-06141224GO:0001758
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

AKR1C4 LBR AKR1C1 AKR1C2 AKR1C3

1.89e-06341225GO:0016628
GeneOntologyMolecularFunctionestradiol 17-beta-dehydrogenase [NAD(P)+] activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.96e-06201224GO:0004303
GeneOntologyMolecularFunctionall-trans-retinol dehydrogenase (NAD+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.28e-05241224GO:0004745
GeneOntologyMolecularFunctionalcohol dehydrogenase (NAD+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.79e-05261224GO:0004022
GeneOntologyMolecularFunctionalcohol dehydrogenase (NADP+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.09e-05271224GO:0008106
GeneOntologyMolecularFunctionalcohol dehydrogenase [NAD(P)+] activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.21e-05301224GO:0018455
GeneOntologyMolecularFunctiontestosterone dehydrogenase [NAD(P)+] activity

AKR1C4 AKR1C1 AKR1C3

3.54e-05111223GO:0030283
GeneOntologyMolecularFunctioncytoskeletal protein binding

ABRA MYH4 WASL MYH8 MYO1E CLIP2 SPTA1 RAB3D ACTR3 MPRIP STX1A BRCA1 BRCA2 XIRP2 KCNQ2 UXT SKA1 RAB3B FRMD3

3.75e-05109912219GO:0008092
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-CH group of donors

AKR1C4 LBR AKR1C1 AKR1C2 AKR1C3

3.84e-05621225GO:0016627
GeneOntologyMolecularFunctionNADP binding

AKR1C4 LBR AKR1C1 AKR1C2 AKR1C3

3.84e-05621225GO:0050661
GeneOntologyMolecularFunctionaldo-keto reductase (NADPH) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.18e-05321224GO:0004033
GeneOntologyMolecularFunctionsteroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.73e-05331224GO:0033764
GeneOntologyMolecularFunctionpyrophosphatase activity

RAB35 MYH4 MYH8 SPG7 CCT3 MYO1E DHX38 RAB3D RRAD GSPT1 LONP1 DCP1B GFM1 RAB3B HSPA14 SMC1B

5.23e-0583912216GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

RAB35 MYH4 MYH8 SPG7 CCT3 MYO1E DHX38 RAB3D RRAD GSPT1 LONP1 DCP1B GFM1 RAB3B HSPA14 SMC1B

5.30e-0584012216GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

RAB35 MYH4 MYH8 SPG7 CCT3 MYO1E DHX38 RAB3D RRAD GSPT1 LONP1 DCP1B GFM1 RAB3B HSPA14 SMC1B

5.30e-0584012216GO:0016818
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

RAB35 MYH4 MYH8 SPG7 CCT3 MYO1E DHX38 RAB3D RRAD GSPT1 LONP1 GFM1 RAB3B HSPA14 SMC1B

7.73e-0577512215GO:0017111
GeneOntologyMolecularFunctionactin filament binding

MYH4 MYH8 MYO1E SPTA1 ACTR3 MPRIP XIRP2 UXT

7.81e-052271228GO:0051015
GeneOntologyMolecularFunctionsteroid dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.25e-05391224GO:0016229
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.02e-04401224GO:0016709
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.10e-04481224GO:0016620
GeneOntologyMolecularFunctionindanol dehydrogenase activity

AKR1C1 AKR1C2

2.20e-0441222GO:0047718
GeneOntologyMolecularFunctionDNA/RNA hybrid binding

POLR3A POLR1B

3.66e-0451222GO:0071667
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.81e-04561224GO:0016903
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.97e-04601224GO:0016655
GeneOntologyMolecularFunctioncalmodulin binding

MYH4 MYH8 CAMK1D MYO1E RRAD ADCY3 KCNQ2

5.36e-042301227GO:0005516
GeneOntologyMolecularFunctionactin binding

ABRA MYH4 WASL MYH8 MYO1E SPTA1 ACTR3 MPRIP XIRP2 UXT

7.22e-0447912210GO:0003779
GeneOntologyMolecularFunctionATP-dependent peptidase activity

SPG7 LONP1

1.01e-0381222GO:0004176
GeneOntologyMolecularFunctiontestosterone dehydrogenase (NAD+) activity

AKR1C4 AKR1C3

1.30e-0391222GO:0047035
GeneOntologyMolecularFunctionsteroid binding

AKR1C4 AKR1C1 AKR1C2 AKR1C3 OSBP2

1.35e-031331225GO:0005496
GeneOntologyMolecularFunctionATP hydrolysis activity

MYH4 MYH8 SPG7 CCT3 MYO1E DHX38 LONP1 HSPA14 SMC1B

1.56e-034411229GO:0016887
GeneOntologyMolecularFunctionmicrofilament motor activity

MYH4 MYH8 MYO1E

1.61e-03381223GO:0000146
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

CAMK1D PDGFRL TSSK2 DGKD MAP3K12 POLR3A TGFBR3 MAST4 PDIK1L BTK PRKAG1 PCYT2 POLR1B PLK4

1.77e-0393812214GO:0016772
GeneOntologyMolecularFunctionmyosin binding

MYH8 RAB3D STX1A RAB3B

1.83e-03851224GO:0017022
GeneOntologyMolecularFunctionsecondary active sulfate transmembrane transporter activity

SLC13A4 SLC26A6

1.96e-03111222GO:0008271
GeneOntologyMolecularFunctionclathrin heavy chain binding

DNAJC6 CLTB

2.35e-03121222GO:0032050
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.75e-03951224GO:0016651
GeneOntologyMolecularFunctionhistone acetyltransferase activity

KAT5 CDY1 BRCA2

3.74e-03511223GO:0004402
GeneOntologyMolecularFunctionprotein kinase activity

CAMK1D PDGFRL TSSK2 MAP3K12 TGFBR3 MAST4 PDIK1L BTK PRKAG1 PLK4

3.78e-0360012210GO:0004672
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

CAMK1D PDGFRL TSSK2 DGKD MAP3K12 TGFBR3 MAST4 PDIK1L BTK PRKAG1 PLK4

4.14e-0370912211GO:0016773
GeneOntologyMolecularFunctionefflux transmembrane transporter activity

SLC26A6 XPR1

4.20e-03161222GO:0015562
GeneOntologyMolecularFunctionsulfate transmembrane transporter activity

SLC13A4 SLC26A6

4.20e-03161222GO:0015116
GeneOntologyMolecularFunctionmonocarboxylic acid binding

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.22e-031071224GO:0033293
GeneOntologyMolecularFunctionATP-dependent activity

MYH4 MYH8 SPG7 CCT3 MYO1E DHX38 MSH3 LONP1 HSPA14 SMC1B

4.44e-0361412210GO:0140657
GeneOntologyMolecularFunctionpeptide-lysine-N-acetyltransferase activity

KAT5 CDY1 BRCA2

4.63e-03551223GO:0061733
GeneOntologyMolecularFunctionadenylate cyclase activity

ADCY3 GUCY1B1

5.31e-03181222GO:0004016
GeneOntologyMolecularFunctionmonooxygenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.44e-031151224GO:0004497
GeneOntologyMolecularFunctionpeptide N-acetyltransferase activity

KAT5 CDY1 BRCA2

5.91e-03601223GO:0034212
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

CAMK1D TSSK2 MAP3K12 TGFBR3 MAST4 PDIK1L PRKAG1 PLK4

6.12e-034461228GO:0004674
GeneOntologyMolecularFunctionmyosin V binding

RAB3D RAB3B

6.55e-03201222GO:0031489
GeneOntologyMolecularFunctionkinase activity

CAMK1D PDGFRL TSSK2 DGKD MAP3K12 TGFBR3 MAST4 PDIK1L BTK PRKAG1 PLK4

7.16e-0376412211GO:0016301
GeneOntologyMolecularFunctionRNA stem-loop binding

EPRS1 DAZAP1

7.21e-03211222GO:0035613
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.70e-031271224GO:0016616
GeneOntologyBiologicalProcessresponse to jasmonic acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.09e-0941204GO:0009753
GeneOntologyBiologicalProcessprogesterone catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.09e-0941204GO:0006709
GeneOntologyBiologicalProcesscellular response to jasmonic acid stimulus

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.09e-0941204GO:0071395
GeneOntologyBiologicalProcessC21-steroid hormone catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.09e-0941204GO:0008208
GeneOntologyBiologicalProcessfarnesol metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.42e-0951204GO:0016487
GeneOntologyBiologicalProcessfarnesol catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.42e-0951204GO:0016488
GeneOntologyBiologicalProcessnegative regulation of isoprenoid metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.42e-0951204GO:0045827
GeneOntologyBiologicalProcesssesquiterpenoid catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.42e-0951204GO:0016107
GeneOntologyBiologicalProcessolefinic compound catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.42e-0951204GO:0120256
GeneOntologyBiologicalProcessnegative regulation of retinoic acid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.42e-0951204GO:1900053
GeneOntologyBiologicalProcesssesquiterpenoid metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.62e-0861204GO:0006714
GeneOntologyBiologicalProcesspolyprenol catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.62e-0861204GO:0016095
GeneOntologyBiologicalProcessresponse to prostaglandin D

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.76e-0871204GO:0071798
GeneOntologyBiologicalProcesscellular response to prostaglandin D stimulus

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.76e-0871204GO:0071799
GeneOntologyBiologicalProcessregulation of retinoic acid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.76e-0871204GO:1900052
GeneOntologyBiologicalProcessdaunorubicin metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.34e-0791204GO:0044597
GeneOntologyBiologicalProcessdoxorubicin metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.23e-07101204GO:0044598
GeneOntologyBiologicalProcessregulation of isoprenoid metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.23e-07101204GO:0019747
GeneOntologyBiologicalProcessnegative regulation of vitamin metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.23e-07101204GO:0046137
GeneOntologyBiologicalProcesspolyketide metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.23e-07101204GO:0030638
GeneOntologyBiologicalProcessaminoglycoside antibiotic metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.23e-07101204GO:0030647
GeneOntologyBiologicalProcessregulation of testosterone biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.48e-07111204GO:2000224
GeneOntologyBiologicalProcessterpenoid catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.48e-07111204GO:0016115
GeneOntologyBiologicalProcessretinoic acid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.04e-06141204GO:0002138
GeneOntologyBiologicalProcessisoprenoid catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.04e-06141204GO:0008300
GeneOntologyBiologicalProcessditerpenoid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.42e-06151204GO:0016102
GeneOntologyBiologicalProcesstestosterone biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.88e-06161204GO:0061370
GeneOntologyBiologicalProcessnegative regulation of hormone metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.88e-06161204GO:0032351
GeneOntologyBiologicalProcessresponse to prostaglandin

AKR1C4 AKR1C1 AKR1C2 TGFBR3 AKR1C3

2.00e-06361205GO:0034694
GeneOntologyBiologicalProcessregulation of vitamin metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.13e-06181204GO:0030656
GeneOntologyBiologicalProcesshormone catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.04e-06211204GO:0042447
GeneOntologyBiologicalProcessterpenoid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.04e-06211204GO:0016114
GeneOntologyBiologicalProcessregulation of retinoic acid receptor signaling pathway

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.04e-06211204GO:0048385
GeneOntologyBiologicalProcessretinal metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.04e-06211204GO:0042574
GeneOntologyBiologicalProcessketone catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.04e-06211204GO:0042182
GeneOntologyBiologicalProcessparturition

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.35e-06221204GO:0007567
GeneOntologyBiologicalProcessglycoside metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.35e-06221204GO:0016137
GeneOntologyBiologicalProcessprogesterone metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.35e-06221204GO:0042448
GeneOntologyBiologicalProcesstertiary alcohol metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.35e-06221204GO:1902644
GeneOntologyBiologicalProcesscellular response to prostaglandin stimulus

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.86e-06231204GO:0071379
GeneOntologyBiologicalProcessprimary alcohol catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.86e-06231204GO:0034310
GeneOntologyBiologicalProcessregulation of ketone biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.48e-05261204GO:0010566
GeneOntologyBiologicalProcessnegative regulation of mRNA splicing, via spliceosome

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.00e-05281204GO:0048025
GeneOntologyBiologicalProcesspolyprenol metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.31e-05291204GO:0016093
GeneOntologyBiologicalProcessnegative regulation of mRNA processing

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.31e-05291204GO:0050686
GeneOntologyBiologicalProcesspositive regulation of endothelial cell apoptotic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.45e-05321204GO:2000353
GeneOntologyBiologicalProcessnegative regulation of RNA splicing

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.91e-05331204GO:0033119
GeneOntologyBiologicalProcesssteroid catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.41e-05341204GO:0006706
GeneOntologyBiologicalProcessolefinic compound biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.96e-05351204GO:0120255
GeneOntologyBiologicalProcessisoprenoid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.56e-05361204GO:0008299
GeneOntologyBiologicalProcessretinoic acid receptor signaling pathway

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.90e-05381204GO:0048384
GeneOntologyBiologicalProcessretinoic acid metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.47e-05401204GO:0042573
GeneOntologyBiologicalProcesspeptidyl-cysteine methylation

RAB3D RAB3B

1.00e-0431202GO:0018125
GeneOntologyBiologicalProcesscellular response to fatty acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.03e-04421204GO:0071398
GeneOntologyBiologicalProcesscellular response to alcohol

AKR1C4 AKR1C1 ADCY3 AKR1C2 BRCA1 AKR1C3

1.13e-041301206GO:0097306
GeneOntologyBiologicalProcessC21-steroid hormone metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.35e-04451204GO:0008207
GeneOntologyBiologicalProcessalcohol catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.60e-04471204GO:0046164
GeneOntologyBiologicalProcesscellular response to calcium ion

AKR1C4 AKR1C1 AKR1C2 AKR1C3 KCNQ2

1.63e-04881205GO:0071277
GeneOntologyBiologicalProcessventricular septum development

NSD2 TRIP11 TGFBR3 XIRP2 FZD2

1.91e-04911205GO:0003281
GeneOntologyBiologicalProcessnegative regulation of lipid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 BRCA1 AKR1C3

1.91e-04911205GO:0051055
GeneOntologyBiologicalProcessregulation of clathrin-dependent endocytosis

WASL DGKD DNAJC6

2.37e-04211203GO:2000369
GeneOntologyBiologicalProcessclathrin-dependent endocytosis

WASL DGKD DNAJC6 CLTB

2.56e-04531204GO:0072583
GeneOntologyBiologicalProcessprostaglandin metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.17e-04561204GO:0006693
GeneOntologyBiologicalProcesspositive regulation of clathrin-dependent endocytosis

WASL DGKD

3.32e-0451202GO:2000370
GeneOntologyBiologicalProcessprostanoid metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.39e-04571204GO:0006692
GeneOntologyBiologicalProcessketone biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.39e-04571204GO:0042181
GeneOntologyBiologicalProcessregulation of hormone metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.63e-04581204GO:0032350
GeneOntologyBiologicalProcesspositive regulation of epithelial cell apoptotic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.13e-04601204GO:1904037
GeneOntologyBiologicalProcessmuscular septum morphogenesis

TGFBR3 FZD2

4.96e-0461202GO:0003150
GeneOntologyBiologicalProcesssecondary metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.29e-04671204GO:0019748
GeneOntologyBiologicalProcessresponse to fatty acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.04e-04691204GO:0070542
GeneOntologyBiologicalProcessregulation of reactive oxygen species metabolic process

SLC25A33 AKR1C4 AKR1C1 AKR1C2 BRCA1 AKR1C3

8.19e-041881206GO:2000377
GeneOntologyBiologicalProcessorganic hydroxy compound catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.70e-04731204GO:1901616
GeneOntologyBiologicalProcessregulation of endothelial cell apoptotic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.16e-04741204GO:2000351
GeneOntologyBiologicalProcessregulation of mRNA splicing, via spliceosome

AKR1C4 AKR1C1 AKR1C2 DAZAP1 AKR1C3

9.50e-041291205GO:0048024
GeneOntologyBiologicalProcesscellular response to ketone

AKR1C4 AKR1C1 ADCY3 AKR1C2 AKR1C3

9.84e-041301205GO:1901655
GeneOntologyBiologicalProcessneutrophil homeostasis

CFH BTK C5

1.10e-03351203GO:0001780
GeneOntologyBiologicalProcesscardiac septum development

NSD2 TRIP11 TGFBR3 XIRP2 FZD2

1.13e-031341205GO:0003279
GeneOntologyBiologicalProcessendothelial cell apoptotic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.17e-03791204GO:0072577
GeneOntologyBiologicalProcesscellular response to corticosteroid stimulus

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.28e-03811204GO:0071384
GeneOntologyBiologicalProcessmembranous septum morphogenesis

NSD2 FZD2

1.47e-03101202GO:0003149
GeneOntologyBiologicalProcesstransepithelial chloride transport

SLC12A2 SLC26A6

1.47e-03101202GO:0030321
GeneOntologyBiologicalProcessmulti-organism reproductive process

AKR1C4 AKR1C1 AKR1C2 DAZAP1 A2ML1 AKR1C3 POLR1B

1.55e-032901207GO:0044703
GeneOntologyBiologicalProcessnegative regulation of lipid metabolic process

AKR1C4 AKR1C1 AKR1C2 BRCA1 AKR1C3

1.60e-031451205GO:0045833
GeneOntologyBiologicalProcesscell cycle process

RAB35 WASL KAT5 ACTR3 GSPT1 BNIP2 BRCA1 BRCA2 CTCF TPX2 BTN2A3P MKI67 PPME1 UXT SKA1 PLK4 PHIP SMC1B

1.68e-03144112018GO:0022402
GeneOntologyBiologicalProcessmulti-multicellular organism process

AKR1C4 AKR1C1 AKR1C2 DAZAP1 A2ML1 AKR1C3 POLR1B

1.68e-032941207GO:0044706
MousePhenoparturition failure

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.33e-07101064MP:0012010
MousePhenohypermyelination

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.89e-07111064MP:0010050
MousePhenoincreased oligodendrocyte number

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.12e-06131064MP:0010160
MousePhenoincreased circulating progesterone level

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.00e-06151064MP:0005186
MousePhenolong stride length

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.00e-06151064MP:0010540
MousePhenolong gestation period

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.00e-06151064MP:0002293
MousePhenoabnormal gestational length

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.81e-06181064MP:0002292
MousePhenodysmyelination

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.38e-05201064MP:0013438
MousePhenodecreased vocalization

AKR1C4 LBR AKR1C1 AKR1C2 AKR1C3

2.44e-05461065MP:0020351
MousePhenodecreased oligodendrocyte number

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.49e-05251064MP:0009808
MousePhenoprolonged diestrus

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.35e-05301064MP:0009011
MousePhenoabnormal parturition

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.08e-04331064MP:0002907
MousePhenoenlarged stomach

ANKRD20A3P ANKRD20A8P GUCY1B1 ANKRD20A1

1.08e-04331064MP:0003883
MousePhenoabnormal diestrus

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.36e-04351064MP:0009010
MousePhenofailure of bone ossification

NSD2 TRIP11 SLC13A4

1.45e-04141063MP:0008274
MousePhenoabnormal red blood cell deformability

SPTA1 PRKAG1

1.70e-0431062MP:0009568
MousePhenoenhanced coordination

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.89e-04381064MP:0003858
MousePhenoprolonged estrous cycle

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.09e-04391064MP:0009006
MousePhenoabnormal synaptic vesicle number

NBEA DNAJC6 STX1A CLTB

2.80e-04421064MP:0004792
MousePhenoabnormal social/conspecific interaction behavior

SPTA1 NBEA AKR1C4 CMYA5 CSMD3 AKR1C1 ADCY3 AKR1C2 STX1A SLC12A2 AKR1C3

3.45e-0442110611MP:0002557
MousePhenoabnormal stride length

MDGA2 AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.91e-04821065MP:0012690
MousePhenoabnormal synaptic vesicle recycling

DNAJC6 STX1A CLTB

5.10e-04211063MP:0004770
MousePhenoabnormal circulating progesterone level

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.50e-04501064MP:0005184
MousePhenoabnormal Wallerian degeneration

MDGA2 MAP3K12

5.61e-0451062MP:0010653
MousePhenoabnormal synaptic vesicle morphology

NBEA DNAJC6 STX1A CLTB

5.93e-04511064MP:0004769
MousePhenoabnormal oligodendrocyte morphology

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.93e-04511064MP:0000953
DomainALDOKETO_REDUCTASE_1

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.30e-07101204PS00798
DomainALDOKETO_REDUCTASE_2

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.30e-07101204PS00062
DomainALDOKETO_REDUCTASE_3

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.30e-07101204PS00063
DomainAldo/ket_reductase_CS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.30e-07101204IPR018170
DomainAldo/keto_reductase

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.30e-07101204IPR020471
Domain-

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.78e-061612043.20.20.100
DomainNADP_OxRdtase_dom

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.62e-06171204IPR023210
DomainAldo_ket_red

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.62e-06171204PF00248
DomainAldo/ket_red/Kv-b

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.62e-06171204IPR001395
Domain-

LONP1 MRPS9 GFM1

3.16e-042112033.30.230.10
DomainRibosomal_S5_D2-typ_fold_subgr

LONP1 MRPS9 GFM1

3.64e-04221203IPR014721
DomainCa/CaM-dep_Ca-dep_prot_Kinase

CAMK1D TSSK2 EFHB PLK4

1.02e-03691204IPR020636
DomainP-loop_NTPase

RAB35 MYH4 MYH8 SPG7 MYO1E DHX38 RAB3D MSH3 RRAD GSPT1 LONP1 GFM1 RAB3B SMC1B

1.09e-0384812014IPR027417
DomainA2M_N_2

A2ML1 C5

1.12e-0381202SM01359
Domain-

A2ML1 C5

1.12e-03812022.60.40.690
DomainA2M_recep

A2ML1 C5

1.12e-0381202SM01361
DomainA2M

A2ML1 C5

1.12e-0381202SM01360
DomainRibosomal_S5_D2-typ_fold

LONP1 MRPS9 GFM1

1.34e-03341203IPR020568
DomainG_TR_CS

GSPT1 GFM1

1.43e-0391202IPR031157
DomainA2M

A2ML1 C5

1.78e-03101202PF00207
DomainA2M_N_2

A2ML1 C5

1.78e-03101202IPR011625
DomainA2M_comp

A2ML1 C5

1.78e-03101202IPR011626
DomainA2M_recep

A2ML1 C5

1.78e-03101202PF07677
DomainA2M_comp

A2ML1 C5

1.78e-03101202PF07678
DomainA2M_N

A2ML1 C5

1.78e-03101202PF01835
DomainA2M_N

A2ML1 C5

1.78e-03101202IPR002890
DomainA-macroglobulin_rcpt-bd

A2ML1 C5

1.78e-03101202IPR009048
DomainALPHA_2_MACROGLOBULIN

A2ML1 C5

1.78e-03101202PS00477
DomainA2M_N_2

A2ML1 C5

1.78e-03101202PF07703
DomainMacroglobln_a2

A2ML1 C5

1.78e-03101202IPR001599
DomainMyosin_head_motor_dom

MYH4 MYH8 MYO1E

1.85e-03381203IPR001609
DomainMYOSIN_MOTOR

MYH4 MYH8 MYO1E

1.85e-03381203PS51456
DomainMyosin_head

MYH4 MYH8 MYO1E

1.85e-03381203PF00063
DomainMYSc

MYH4 MYH8 MYO1E

1.85e-03381203SM00242
Domain-

A2ML1 C5

2.59e-031212021.50.10.20
DomainG_TR_1

GSPT1 GFM1

3.05e-03131202PS00301
Domain-

RAB35 SPG7 MYO1E DHX38 RAB3D MSH3 RRAD GSPT1 LONP1 GFM1 RAB3B SMC1B

3.09e-03746120123.40.50.300
DomainMyosin_N

MYH4 MYH8

4.07e-03151202PF02736
DomainMyosin_N

MYH4 MYH8

4.07e-03151202IPR004009
DomainIGc2

BOC MYOM1 PDGFRL MDGA2 IGSF10 IGSF3

4.13e-032351206SM00408
DomainIg_sub2

BOC MYOM1 PDGFRL MDGA2 IGSF10 IGSF3

4.13e-032351206IPR003598
DomainSmall_GTP-bd_dom

RAB35 RAB3D RRAD GFM1 RAB3B

4.49e-031671205IPR005225
DomainSushi

CFH PAPPA2 CSMD3

4.55e-03521203PF00084
DomainCCP

CFH PAPPA2 CSMD3

5.05e-03541203SM00032
DomainA/G_cyclase_CS

ADCY3 GUCY1B1

5.23e-03171202IPR018297
DomainSUSHI

CFH PAPPA2 CSMD3

5.60e-03561203PS50923
DomainMyosin_tail_1

MYH4 MYH8

5.86e-03181202PF01576
DomainMyosin_tail

MYH4 MYH8

5.86e-03181202IPR002928
DomainEFTu-like_2

GSPT1 GFM1

5.86e-03181202IPR004161
DomainTerpenoid_cyclase/PrenylTrfase

A2ML1 C5

5.86e-03181202IPR008930
Domain-

ADCY3 GUCY1B1

5.86e-031812023.30.70.1230
DomainNucleotide_cyclase

ADCY3 GUCY1B1

5.86e-03181202IPR029787
DomainGTP_EFTU_D2

GSPT1 GFM1

5.86e-03181202PF03144
DomainG_TR_2

GSPT1 GFM1

5.86e-03181202PS51722
DomainSushi_SCR_CCP_dom

CFH PAPPA2 CSMD3

5.88e-03571203IPR000436
DomainPH_dom-like

WASL DGKD NBEA MPRIP DCP1B BTK OSBP2 FRMD3

6.26e-034261208IPR011993
PathwayWP_BENZOAPYRENE_METABOLISM

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.18e-079934M39344
PathwayKEGG_MEDICUS_ENV_FACTOR_METALS_TO_KEAP1_NRF2_SIGNALIG_PATHWAY

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.18e-079934M47817
PathwayKEGG_MEDICUS_ENV_FACTOR_BENZO_A_PYRENRE_TO_CYP_MEDIATED_METABOLISM

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.65e-0711934M47812
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.21e-0613934M17842
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.21e-0613934MM14747
PathwayWP_GLUCOCORTICOID_BIOSYNTHESIS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.69e-0614934M46449
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.69e-0614934M27074
PathwayWP_MINERALOCORTICOID_BIOSYNTHESIS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.69e-0614934M46453
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.69e-0614934MM14748
PathwayREACTOME_SYNTHESIS_OF_PROSTAGLANDINS_PG_AND_THROMBOXANES_TX

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.29e-0615934MM14870
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.43e-0523934M1926
PathwayREACTOME_PREDNISONE_ADME

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.43e-0523934MM16639
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.43e-0523934MM14741
PathwayREACTOME_RA_BIOSYNTHESIS_PATHWAY

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.22e-0528934MM15188
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.27e-0533934M5967
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.27e-0533934MM14737
PathwayREACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.97e-0444934M499
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.15e-0445934MM15344
PathwayREACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.15e-0445934MM14751
PathwayREACTOME_SIGNALING_BY_RETINOIC_ACID

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.00e-0449934MM15186
PathwayREACTOME_DISEASES_OF_DNA_REPAIR

KAT5 MSH3 BRCA1 BRCA2

3.50e-0451934M29854
PathwayKEGG_STEROID_HORMONE_BIOSYNTHESIS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.68e-0455934M14933
PathwayREACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE

KAT5 BRCA1 BRCA2

6.47e-0426933MM15297
PathwayREACTOME_ARACHIDONIC_ACID_METABOLISM

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.95e-0461934MM14861
PathwayREACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES_THROUGH_SYNTHESIS_DEPENDENT_STRAND_ANNEALING_SDSA

KAT5 BRCA1 BRCA2

7.25e-0427933M27586
Pubmed

Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1).

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124410500239
Pubmed

AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124419487289
Pubmed

Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124414967952
Pubmed

Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124410393440
Pubmed

Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124415193432
Pubmed

Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124431479646
Pubmed

Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124416191478
Pubmed

Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124415577209
Pubmed

Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124410702227
Pubmed

Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124417034817
Pubmed

RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124429764944
Pubmed

Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124417888864
Pubmed

Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124417442338
Pubmed

Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124428329705
Pubmed

Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124419237748
Pubmed

Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124428259989
Pubmed

Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124416511129
Pubmed

Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-10412447789999
Pubmed

Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124420124700
Pubmed

Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124416508162
Pubmed

Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124415222881
Pubmed

Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124417629694
Pubmed

Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124410526179
Pubmed

Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124416018803
Pubmed

Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124417272929
Pubmed

Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124418667791
Pubmed

Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124421521174
Pubmed

Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-10412448274401
Pubmed

Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124410803568
Pubmed

AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-104124434590152
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

CFH EPRS1 DMXL2 WASL WDR4 MYO1E CLIP2 NBEA MSH3 ZFC3H1 CMYA5 TRIP11 YWHAG MPRIP FAIM STX1A DAZAP1 GUCY1B1 AKR1C3 MRPS9 PPME1 KCNQ2 BTRC

1.63e-1012851242335914814
Pubmed

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.67e-105124421851338
Pubmed

Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.67e-105124416984997
Pubmed

Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.67e-10512447737980
Pubmed

Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.67e-105124417872381
Pubmed

Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: a marker of lung maturity.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.67e-105124417064890
Pubmed

Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.67e-105124410672042
Pubmed

Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F2α (PGF2α) levels.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.67e-105124438788959
Pubmed

Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.67e-105124418003893
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

PITPNM2 EPRS1 DMXL2 WASL DNAJC13 CCT3 MYO1E CLIP2 SPTA1 RAB3D NBEA DNAJC6 TRIP11 YWHAG ACTR3 MRPS22 MYEF2 LACTB MPRIP TGM1 LONP1 MRPS9 KCNQ2

1.30e-0914311242337142655
Pubmed

Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.30e-096124419273550
Pubmed

Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.30e-096124415471942
Pubmed

MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.30e-096124426748576
Pubmed

The Gαq/11-provoked induction of Akr1c18 in murine luteal cells is mediated by phospholipase C.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.30e-096124429107092
Pubmed

Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.30e-096124415860270
Pubmed

Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.30e-096124417122075
Pubmed

Decidual prolactin silences the expression of genes detrimental to pregnancy.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.30e-096124417255200
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

BOC ABRA DMXL2 WASL MYH8 MYOM1 DGKD RRAD CMYA5 TRIP11 AKR1C2 BNIP2 GSDME XIRP2

3.20e-094971241423414517
Pubmed

MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.34e-097124422529366
Pubmed

A phosphodiesterase 11 (Pde11a) knockout mouse expressed functional but reduced Pde11a: Phenotype and impact on adrenocortical function.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.34e-097124433127481
Pubmed

A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.34e-097124412562828
Pubmed

The Steroidogenic Enzyme AKR1C3 Regulates Stability of the Ubiquitin Ligase Siah2 in Prostate Cancer Cells.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.34e-097124426160177
Pubmed

Aldo-ketoreductase 1c19 ablation does not affect insulin secretion in murine islets.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.34e-097124434843575
Pubmed

17Beta-HSD type 5 expression and the emergence of differentiated epithelial Type II cells in fetal lung: a novel role for androgen during the surge of surfactant.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.34e-097124416337335
Pubmed

A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing.

AKR1C4 AKR1C1 AKR1C2 DAZAP1 AKR1C3

7.89e-0920124523636947
Pubmed

Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.07e-088124433584538
Pubmed

Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.07e-08812449224647
Pubmed

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.07e-088124420837989
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

EPRS1 DNAJC13 CCT3 DHX38 NOB1 DGKD MSH3 LBR YWHAG ACTR3 MYEF2 GSPT1 POLR3A MPRIP TGM1 LONP1 A2ML1 MKI67 POLR1B PHIP BTRC

1.37e-0813531242129467282
Pubmed

Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.91e-089124433348080
Pubmed

Lack of placental neurosteroid alters cortical development and female somatosensory function.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.18e-0810124436313771
Pubmed

Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.

AKR1C1 AKR1C2 AKR1C3

4.42e-083124319320734
Pubmed

Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.

AKR1C1 AKR1C2 AKR1C3

4.42e-083124331780644
Pubmed

Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes.

AKR1C1 AKR1C2 AKR1C3

4.42e-083124313678667
Pubmed

Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans.

AKR1C4 AKR1C1 AKR1C3

4.42e-08312437626489
Pubmed

Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.

AKR1C1 AKR1C2 AKR1C3

4.42e-083124321232532
Pubmed

A Novel Population of Inner Cortical Cells in the Adrenal Gland That Displays Sexually Dimorphic Expression of Thyroid Hormone Receptor-β1.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.45e-0812124425774556
Pubmed

Endogenous biotin as a marker of adrenocortical cells with steroidogenic potential.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.45e-0812124421256921
Pubmed

Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.45e-0812124428893949
Pubmed

The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.07e-0713124411682476
Pubmed

A link between lung androgen metabolism and the emergence of mature epithelial type II cells.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.07e-0713124415117747
Pubmed

Ontogeny of adrenal-like glucocorticoid synthesis pathway and of 20α-hydroxysteroid dehydrogenase in the mouse lung.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.07e-0713124424580729
Pubmed

Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.07e-0713124417062636
Pubmed

Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.50e-0714124419955443
Pubmed

Placental endocrine function shapes cerebellar development and social behavior.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.50e-0714124434400844
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

DNAJC13 LZTR1 CCT3 NSD2 CALU DHX38 NBEA YWHAG ACTR3 LONP1 SLC12A2 CLTB MKI67 PPME1 UXT PLK4 BTRC

2.08e-0710491241727880917
Pubmed

Targeted Disruption of Lats1 and Lats2 in Mice Impairs Adrenal Cortex Development and Alters Adrenocortical Cell Fate.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.53e-0717124432243503
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

EPRS1 DNAJC13 CLIP2 CALU DHX38 ZFC3H1 MRPS22 MPRIP CTCF A2ML1 TPX2 MKI67 MRPS9 PCYT2 POLR1B

3.78e-078471241535850772
Pubmed

Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma.

AKR1C1 AKR1C2 AKR1C3

4.40e-075124315212687
Pubmed

Functional dynamics of H3K9 methylation during meiotic prophase progression.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.72e-0719124417599069
Pubmed

WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.13e-0720124424135228
Pubmed

Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers.

CAMK1D BRCA1 BRCA2

8.78e-076124320418484
Pubmed

Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers.

BRCA1 BRCA2 TPX2

8.78e-076124325830658
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

EPRS1 CCT3 DHX38 NOB1 LBR ACTR3 MRPS22 GSPT1 LONP1 SETSIP BTK MKI67 PRKAG1 MRPS9 PPME1 POLR1B AMMECR1 PHIP

1.06e-0613181241830463901
Pubmed

Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.

AKR1C4 AKR1C1 AKR1C2 MKI67 AKR1C3

1.21e-0652124523260145
Pubmed

Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a renal stromal fate.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.29e-0623124423685333
Pubmed

Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk.

AKR1C1 AKR1C2 AKR1C3

1.53e-067124319846565
Pubmed

FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.

EPRS1 DNAJC13 CCT3 MYO1E CALU LBR YWHAG MPRIP LONP1 CTCF PRKAG1 MRPS9

1.75e-066011241233658012
Pubmed

Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.84e-0625124426098214
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

WASL DNAJC13 MYO1E NOB1 ZFC3H1 ACTR3 LACTB GSPT1 MPRIP BRCA1 MKI67 POLR1B RAB3B

2.04e-067241241336232890
Pubmed

Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.17e-0626124423892084
Pubmed

Expression of testicular germ cell genes identified by differential display analysis.

ANKRD20A3P ANKRD20A8P ANKRD20A1

2.45e-068124312634303
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

EPRS1 CCT3 MYO1E DHX38 NOB1 ZFC3H1 YWHAG ACTR3 MRPS22 LACTB MPRIP SETSIP TPX2 MKI67 MRPS9 POLR1B HSPA14

2.48e-0612571241736526897
Pubmed

Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.53e-0627124417077188
Pubmed

Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.53e-0627124423471215
Pubmed

Identification of differentially expressed genes in mouse spermatogenesis.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.53e-0627124414581517
Pubmed

The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.95e-0628124429212953
Pubmed

MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.95e-0628124429879378
Pubmed

Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.

AKR1C1 AKR1C2 AKR1C3 HSPA14

2.95e-0628124420689807
Pubmed

Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.95e-0628124421820362
InteractionAKR1C4 interactions

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.08e-0881234int:AKR1C4
InteractionRPRD1B interactions

CCT3 CALU ACTR3 POLR3A LONP1 BRCA1 PPME1 POLR1B UXT BTRC

1.69e-0623312310int:RPRD1B
InteractionAKR1C1 interactions

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.94e-06201234int:AKR1C1
InteractionKCTD13 interactions

PITPNM2 EPRS1 DMXL2 WASL DNAJC13 CCT3 MYO1E CLIP2 SPTA1 RAB3D NBEA DNAJC6 TRIP11 YWHAG ACTR3 MRPS22 MYEF2 LACTB MPRIP TGM1 LONP1 MRPS9 KCNQ2

1.07e-05139412323int:KCTD13
Cytoband10p15-p14

AKR1C1 AKR1C2 AKR1C3

3.82e-076124310p15-p14
CytobandEnsembl 112 genes in cytogenetic band chr10p15

AKR1C8 AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.85e-06901245chr10p15
Cytoband16q22

DHX38 RRAD

9.58e-0417124216q22
CytobandEnsembl 112 genes in cytogenetic band chr16q22

DHX38 NOB1 RRAD CTCF

1.58e-031831244chr16q22
CytobandEnsembl 112 genes in cytogenetic band chr9q21

ANKRD20A3P CARNMT1 ANKRD20A1 FRMD3

2.14e-031991244chr9q21
Cytoband7q11.23

CLIP2 YWHAG STX1A

2.36e-039712437q11.23
Cytoband10p15.1

AKR1C8 AKR1C4

2.61e-0328124210p15.1
Cytoband9p12

ANKRD20A2P ANKRD20A3P

2.80e-032912429p12
GeneFamilyAldo-keto reductases

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.06e-0615984399
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

A2ML1 C5

1.02e-0399821234
CoexpressionHE_LIM_SUN_FETAL_LUNG_C3_CYCLING_DEFINITIVE_ERYTHROBLAST

WDR4 NSD2 SPTA1 DNAJC6 BRCA1 BRCA2 TPX2 MKI67 PPME1 OSBP2 AMMECR1 SKA1 PLK4

1.91e-0745012213M45747
CoexpressionBAKKER_FOXO3_TARGETS_DN

WDR4 CALU AKR1C4 AKR1C1 AKR1C2 MKI67 PRKAG1 AKR1C3 PCYT2

2.52e-071881229MM904
CoexpressionGSE37532_TREG_VS_TCONV_PPARG_KO_CD4_TCELL_FROM_LN_UP

SLC25A33 DGKD MSH3 LBR TAX1BP3 BNIP2 CTCF BTK MKI67

4.25e-072001229M8959
CoexpressionHALLMARK_G2M_CHECKPOINT

NSD2 LBR GSPT1 SLC12A2 BRCA2 CTCF TPX2 MKI67 PLK4

4.25e-072001229M5901
CoexpressionWANG_IMMORTALIZED_BY_HOXA9_AND_MEIS1_UP

AKR1C4 AKR1C1 AKR1C2 TGFBR3 AKR1C3

7.78e-07371225MM630
CoexpressionIRITANI_MAD1_TARGETS_UP

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.01e-06171224MM826
CoexpressionSHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM3

AKR1C4 AKR1C1 AKR1C2 MYEF2 MKI67 AKR1C3

1.89e-06791226MM535
CoexpressionZAMORA_NOS2_TARGETS_DN

CFH AKR1C4 AKR1C1 AKR1C2 LONP1 AKR1C3

3.81e-06891226MM690
CoexpressionLIN_TUMOR_ESCAPE_FROM_IMMUNE_ATTACK

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.42e-06241224MM766
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_C_DN

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.24e-06251224MM480
CoexpressionHAY_BONE_MARROW_ERYTHROBLAST

EPRS1 WDR4 CCT3 SPTA1 LBR DNAJC6 YWHAG AKR1C1 MRPS22 GSPT1 BRCA1 BRCA2 AKR1C3 MRPS9 PPME1 OSBP2 AMMECR1 SKA1 PLK4

6.57e-06127112219M39197
CoexpressionBYSTRYKH_HEMATOPOIESIS_STEM_CELL_SCP2_QTL_TRANS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.11e-05301224MM853
CoexpressionFEVR_CTNNB1_TARGETS_DN

CCT3 MSH3 LBR MRPS22 SLC12A2 BRCA1 BRCA2 CTCF MKI67 POLR1B CARNMT1 SKA1

1.13e-0555512212M2343
CoexpressionIVANOVA_HEMATOPOIESIS_STEM_CELL_LONG_TERM

MYOM1 NBEA AKR1C4 AKR1C1 AKR1C2 LACTB SLC12A2 AKR1C3

1.19e-052281228MM1014
CoexpressionPUJANA_XPRSS_INT_NETWORK

NSD2 LBR BRCA1 BRCA2 CTCF MKI67 PLK4

1.41e-051681227M18811
CoexpressionNADLER_HYPERGLYCEMIA_AT_OBESITY

AKR1C4 AKR1C1 AKR1C2 CLTB AKR1C3

1.43e-05661225MM631
CoexpressionLI_CISPLATIN_RESISTANCE_DN

CFH AKR1C1 XIRP2 AKR1C3

1.65e-05331224M10150
CoexpressionGREENBAUM_E2A_TARGETS_UP

EPRS1 SLC12A2 MKI67 PLK4

1.65e-05331224M1490
CoexpressionGREENBAUM_E2A_TARGETS_UP

EPRS1 SLC12A2 MKI67 PLK4

1.86e-05341224MM1160
CoexpressionDESCARTES_ORGANOGENESIS_PRIMITIVE_ERYTHROID_LINEAGE

SPTA1 ANKRD20A3P ANKRD20A8P LBR BRCA2 PDIK1L TPX2 MKI67 POLR1B BTRC ANKRD20A1

2.16e-0549712211MM3640
CoexpressionDESCARTES_ORGANOGENESIS_INTERMEDIATE_MESODERM

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.34e-05361224MM3660
CoexpressionGSE13547_CTRL_VS_ANTI_IGM_STIM_BCELL_2H_UP

NSD2 CALU BRCA1 BRCA2 TPX2 MKI67 DZIP3

2.46e-051831227M2993
CoexpressionGSE13547_CTRL_VS_ANTI_IGM_STIM_BCELL_12H_UP

CALU BRCA1 BRCA2 TPX2 MKI67 PRKAG1 SKA1

2.82e-051871227M2984
CoexpressionBRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A

DMXL2 MYO1E AKR1C4 ANKRD20A3P ANKRD20A8P CMYA5 ITGA7 YWHAG AKR1C1 AKR1C2 TAX1BP3 BNIP2 BRCA2 AKR1C3 ANKRD20A1

2.85e-0593012215MM893
CoexpressionSERVITJA_LIVER_HNF1A_TARGETS_DN

CFH CAMK1D AKR1C4 AKR1C1 AKR1C2 AKR1C3 C5

3.12e-051901227MM1311
CoexpressionFLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_DN

BRCA1 BRCA2 TPX2 MKI67 C5 SKA1 PLK4

3.12e-051901227M761
CoexpressionGSE39556_UNTREATED_VS_3H_POLYIC_INJ_MOUSE_NK_CELL_UP

MSH3 GSDME BRCA1 GUCY1B1 BTK DZIP3 PLK4

4.19e-051991227M9410
CoexpressionHALLMARK_E2F_TARGETS

LBR GSPT1 BRCA1 BRCA2 CTCF MKI67 PLK4

4.33e-052001227M5925
CoexpressionDEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN

ZFC3H1 ITGA7 ADCY3 BRCA1 MKI67 PCYT2 FZD2 IGSF3

4.67e-052761228M3063
CoexpressionEPPERT_PROGENITOR

CALU SPTA1 MSH3 DNAJC6 BTK PLK4

4.68e-051381226M19232
CoexpressionVARELA_ZMPSTE24_TARGETS_DN

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.74e-05451224MM1173
CoexpressionRAO_BOUND_BY_SALL4_ISOFORM_A

CALU AKR1C4 AKR1C1 AKR1C2 XIRP2 AKR1C3 PPME1

5.89e-052101227MM958
CoexpressionGSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_DN

MYH4 NBEA GSDME BRCA1 PDIK1L PLK4

6.41e-051461226M452
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN

WDR4 RAB3D MSH3 LBR TRIP11 POLR3A FAIM DAZAP1 POLR1B SKA1 PLK4 PHIP XPR1

6.87e-0577612213M1107
CoexpressionBRUINS_UVC_RESPONSE_VIA_TP53_GROUP_D

BOC RAB3D AKR1C4 CSMD3 AKR1C1 AKR1C2 TGFBR3 AKR1C3

7.09e-052931228MM895
CoexpressionRAY_TUMORIGENESIS_BY_ERBB2_CDC25A_UP

NBEA AKR1C4 AKR1C1 AKR1C2 BRCA2 MKI67 AKR1C3

7.67e-052191227MM1237
CoexpressionLAZARO_GENETIC_MOUSE_MODEL_HIGH_GRADE_SMALL_CELL_NEUROENDOCRINE_LUNG_CARCINOMA_UP

NSD2 NBEA MSH3 MAP3K12 MYEF2 STX1A BRCA2 TPX2 MKI67 PPME1 SKA1 PLK4

8.14e-0568012212MM456
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HPROGBP

BOC LBR BRCA1 BRCA2 TPX2 MKI67 KCNQ2 FZD2

8.36e-053001228M39059
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN

WDR4 RAB3D MSH3 LBR TRIP11 POLR3A FAIM DAZAP1 POLR1B SKA1 PLK4 PHIP XPR1

8.65e-0579412213MM982
CoexpressionKANG_DOXORUBICIN_RESISTANCE_UP

NSD2 TPX2 MKI67 PLK4

1.18e-04541224M1037
CoexpressionDURCHDEWALD_SKIN_CARCINOGENESIS_UP

NSD2 AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.74e-041111225MM705
CoexpressionPUJANA_BRCA2_PCC_NETWORK

NSD2 LBR BRCA1 BRCA2 CTCF TPX2 MKI67 FZD2 PLK4

1.76e-044261229M9516
CoexpressionMARSON_FOXP3_TARGETS_DN

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.78e-04601224MM847
CoexpressionBOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP

CFH CALU RRAD AKR1C1 TGFBR3 GSDME GUCY1B1 TPX2 IGSF3

1.79e-044271229M17923
CoexpressionHE_LIM_SUN_FETAL_LUNG_C5_LARGE_PRE_B_CELL

EPRS1 NSD2 CALU MSH3 YWHAG GSPT1 FAIM BRCA1 DAZAP1 BRCA2 CTCF TPX2 MKI67 MRPS9 PPME1 SKA1 PLK4

1.95e-04136312217M45782
CoexpressionBLUM_RESPONSE_TO_SALIRASIB_DN

AKR1C1 BRCA1 GUCY1B1 TPX2 MKI67 FZD2 PLK4 HSPA14

2.01e-043411228M2879
CoexpressionRODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP

EPRS1 WDR4 CALU TRIP11 GSPT1 LONP1 BRCA1 MKI67 MRPS9 GFM1 HSPA14

2.16e-0464412211M10501
CoexpressionWHITEFORD_PEDIATRIC_CANCER_MARKERS

NSD2 ADCY3 TPX2 MKI67 PLK4

2.22e-041171225M7854
CoexpressionDIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP

CFH CCT3 CALU SPTA1 LBR ACTR3 GSPT1 BNIP2 BRCA1 DAZAP1 GUCY1B1 CTCF BTK PRKAG1 AKR1C3 PCYT2 AMMECR1

2.65e-04139912217M535
CoexpressionGOLDRATH_IMMUNE_MEMORY

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.06e-04691224MM621
CoexpressionGSE22611_UNSTIM_VS_6H_MDP_STIM_NOD2_TRANSDUCED_HEK293T_CELL_UP

RAB3D ZFC3H1 DNAJC6 TGFBR3 STX1A SKA1

3.19e-041961226M8147
CoexpressionGSE16450_CTRL_VS_IFNA_12H_STIM_IMMATURE_NEURON_CELL_LINE_UP

NBEA POLR3A MPRIP GFM1 BTRC XPR1

3.28e-041971226M7403
CoexpressionHALLMARK_MITOTIC_SPINDLE

WASL MYO1E CLIP2 BRCA2 TPX2 UXT

3.46e-041991226M5893
CoexpressionGSE15930_NAIVE_VS_24H_IN_VITRO_STIM_CD8_TCELL_DN

CCT3 MRPS22 BRCA1 MKI67 GFM1 PLK4

3.46e-041991226M3588
CoexpressionGSE15930_NAIVE_VS_24H_IN_VITRO_STIM_IL12_CD8_TCELL_DN

CCT3 MRPS22 BRCA1 MKI67 GFM1 PLK4

3.46e-041991226M3591
CoexpressionGSE15930_NAIVE_VS_24H_IN_VITRO_STIM_INFAB_CD8_TCELL_DN

CCT3 MRPS22 BRCA1 MKI67 GFM1 PLK4

3.46e-041991226M3594
CoexpressionGSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN

CFH SASH1 PDGFRL SPTA1 TGM1 BRCA2

3.46e-041991226M6837
CoexpressionGSE30083_SP2_VS_SP4_THYMOCYTE_UP

BOC CAMK1D CCT3 CMYA5 AKR1C3 CARNMT1

3.55e-042001226M5034
CoexpressionGSE31082_DN_VS_DP_THYMOCYTE_UP

EPRS1 WDR4 MRPS22 GSPT1 LONP1 CARNMT1

3.55e-042001226M5054
CoexpressionGSE35543_IN_VITRO_ITREG_VS_CONVERTED_EX_ITREG_UP

TSSK2 LBR RRAD BRCA1 MKI67 SKA1

3.55e-042001226M9437
CoexpressionGSE24634_NAIVE_CD4_TCELL_VS_DAY5_IL4_CONV_TREG_DN

EPRS1 CCT3 LONP1 BRCA1 PRKAG1 HSPA14

3.55e-042001226M4589
CoexpressionGSE10273_HIGH_IL7_VS_HIGH_IL7_AND_IRF4_IN_IRF4_8_NULL_PRE_BCELL_DN

MYO1E MYEF2 MPRIP LONP1 CTCF SKA1

3.55e-042001226M317
CoexpressionGSE27786_BCELL_VS_NKCELL_UP

SPG7 TSSK2 LONP1 CTCF CSGALNACT1 BTRC

3.55e-042001226M4805
CoexpressionGSE20727_CTRL_VS_DNFB_ALLERGEN_TREATED_DC_UP

MDGA2 DCP1B PDIK1L CARNMT1 UXT AMMECR1

3.55e-042001226M9254
CoexpressionGSE22886_DC_VS_MONOCYTE_UP

EPRS1 MYO1E ADCY3 TAX1BP3 LONP1 BRCA2

3.55e-042001226M4471
CoexpressionGSE7764_IL15_TREATED_VS_CTRL_NK_CELL_24H_UP

WDR4 CALU BRCA1 CARNMT1 PLK4 HSPA14

3.55e-042001226M5723
CoexpressionGSE9878_CTRL_VS_EBF_TRANSDUCED_PAX5_KO_PRO_BCELL_DN

EPRS1 RAB35 WDR4 NSD2 BRCA1 TPX2

3.55e-042001226M6989
CoexpressionMATZUK_SPERMATOCYTE

DAZAP1 BRCA2 BTRC SMC1B

3.60e-04721224M1831
CoexpressionMATZUK_SPERMATOCYTE

DAZAP1 BRCA2 BTRC SMC1B

3.79e-04731224MM1234
CoexpressionTONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP

EPRS1 SASH1 CALU GSPT1 AKR1C3 PPME1

3.85e-042031226M10184
CoexpressionHE_LIM_SUN_FETAL_LUNG_C2_APOE_POS_M2_MACROPHAGE_CELL

RAB35 LZTR1 SASH1 MYO1E CALU POLR3A LONP1 PPME1 PCYT2

3.97e-044761229M45717
CoexpressionBREDEMEYER_RAG_SIGNALING_NOT_VIA_ATM_UP

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.00e-04741224MM769
CoexpressionHE_LIM_SUN_FETAL_LUNG_C2_MEGAKARYOCYTE

MYOM1 CLIP2 CALU DGKD IGSF10 STX1A MAST4 XIRP2 GUCY1B1 OSBP2 FRMD3

4.07e-0469412211M45731
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HDA1

NBEA CSMD3 DNAJC6 YWHAG AKR1C1 AKR1C2 MYEF2 GSDME RAB3B XPR1

4.13e-0458412210M39068
CoexpressionRAO_BOUND_BY_SALL4_ISOFORM_B

SPTA1 AKR1C4 LBR EFHB AKR1C1 AKR1C2 DCP1B BTN2A3P AKR1C3 PHIP

4.13e-0458412210MM1080
CoexpressionBROWN_MYELOID_CELL_DEVELOPMENT_DN

AKR1C4 AKR1C1 AKR1C2 AKR1C3 POLR1B

4.76e-041381225MM1151
CoexpressionPUIFFE_INVASION_INHIBITED_BY_ASCITES_UP

AKR1C1 GSPT1 TPX2 AKR1C3

5.13e-04791224M3737
CoexpressionDAZARD_RESPONSE_TO_UV_NHEK_DN

ZFC3H1 MAST4 CTCF MKI67 AKR1C3 PLK4 PHIP

5.23e-043001227M8702
CoexpressionKRAS.PROSTATE_UP.V1_DN

CAMK1D RRAD TGM1 KCNQ2 C5

5.25e-041411225M2901
CoexpressionNUYTTEN_NIPP1_TARGETS_DN

NSD2 RAB3D LBR YWHAG FAIM SLC12A2 PDIK1L MKI67 OSBP2 C5 AMMECR1 GFM1

5.91e-0484512212M18090
CoexpressionFISCHER_DREAM_TARGETS

WDR4 NSD2 MSH3 LBR LONP1 BRCA1 BRCA2 CTCF TPX2 MKI67 DZIP3 SKA1 PLK4

5.93e-0496912213M149
CoexpressionCAIRO_HEPATOBLASTOMA_CLASSES_UP

EPRS1 CCT3 PDGFRL NSD2 CALU DGKD DAZAP1 BRCA2 TPX2 MKI67

5.94e-0461212210M4772
CoexpressionHARALAMBIEVA_PBMC_M_M_R_II_AGE_11_22YO_VACCINATED_VS_UNVACCINATED_7YR_UP

SASH1 MYO1E PDGFRL SPTA1 CMYA5 ITGA7 DNAJC6 TGM1 BRCA2 GUCY1B1 TPX2 C5 FRMD3

6.16e-0497312213M41080
CoexpressionSENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP

CFH EPRS1 WASL SLC25A33 IGSF10 FAIM SLC12A2 ANKRD20A1

6.21e-044041228M19488
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

MDGA2 NBEA CSMD3 DNAJC6 YWHAG AKR1C1 AKR1C2 MAST4 PDIK1L RAB3B CSGALNACT1 FRMD3 IGSF3 XPR1

6.43e-04110612214M39071
CoexpressionHOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_DN

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.76e-04851224MM802
CoexpressionSERVITJA_LIVER_HNF1A_TARGETS_UP

AKR1C4 AKR1C1 AKR1C2 TPX2 AKR1C3

6.95e-041501225MM936
CoexpressionAtlasPP_RBC_top-relative-expression-ranked_2500_k-means-cluster#2

CAMK1D WDR4 SPTA1 ANKRD20A3P LBR PDIK1L TPX2 MKI67 AKR1C3 MRPS9 PCYT2 OSBP2 TTC13 AMMECR1 SKA1 PLK4 BTRC PGBD2

7.99e-0695712118PP_RBC_2500_K2
CoexpressionAtlasDevelopingGonad_e14.5_ ovary_emap-6699_top-relative-expression-ranked_1000

DMXL2 MYH8 DNAJC13 CCT3 DGKD GSDME MAST4 SLC12A2 BRCA1 BRCA2 PDIK1L DZIP3 CARNMT1 CSGALNACT1 BTRC SMC1B

8.66e-0677612116gudmap_developingGonad_e14.5_ ovary_1000
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#3_top-relative-expression-ranked_500

CFH BOC PAPPA2 MYH8 IGSF10 GUCY1B1

7.13e-051221216gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k3_500
CoexpressionAtlasStem Cells, SC.CMP.BM, Lineage- Kit+ Sca1- CD34+ FcgRlow, Bone marrow, avg-2

DNAJC6 TGFBR3 BRCA1 BRCA2 BTK TPX2 MKI67 POLR1B CARNMT1

8.60e-053171219GSM791117_500
CoexpressionAtlasStem Cells, SC.MEP.BM, Lineage- Kit+ Sca1- CD34- FcgR-/low, Bone marrow, avg-2

SPTA1 DNAJC6 BRCA1 BRCA2 TPX2 MKI67 POLR1B CARNMT1 AMMECR1 PLK4

1.01e-0440112110GSM791108_500
ToppCellCOVID-19-Heart-CM_3|Heart / Disease (COVID-19 only), tissue and cell type

ABRA MYOM1 DGKD CMYA5 MAST4 DCP1B XIRP2 XPR1

4.53e-081821248287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCellwk_15-18-Hematologic-Meg-ery-Cycling_definitive_erythroblast|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SPTA1 LBR DNAJC6 BRCA2 MKI67 OSBP2 AMMECR1 ANKRD20A1

4.93e-081841248238eba615b4e04967d44ac7858a6673bdd7f67e9
ToppCellLPS_anti-TNF-Endothelial-Endothelial-FOXM1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

NSD2 LBR MYEF2 BRCA1 BRCA2 TPX2 MKI67 SKA1

9.03e-08199124898575fcce726589e93fbb4df1aab03e57cb56076
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW13-Stem_cells|GW13 / Sample Type, Dataset, Time_group, and Cell type.

DMXL2 MYO1E ADCY3 GALNT13 MAST4 BRCA2 CTCF TPX2

9.39e-082001248d933978b55fefe52cad599b36f6b47a0c7f71f96
ToppCellBiopsy_Control_(H.)-Immune-Proliferating_Macrophages|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

AKR1C2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4 SMC1B

9.39e-082001248ce9fad55f779afd3d6c5a9c5a15e2d9f548b7c7e
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW13-Stem_cells-Neuroepithelial_cell|GW13 / Sample Type, Dataset, Time_group, and Cell type.

DMXL2 MYO1E ADCY3 GALNT13 MAST4 BRCA2 CTCF TPX2

9.39e-0820012483d932765c31aef1f80a118d51e8e66c50a758dbb
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

5.90e-07174124784da9faff088d05233183b425385beb054c92d1b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

5.90e-071741247dbb4e1a6c3319ce40f81bfd2d1745a88a2cc412e
ToppCellwk_20-22-Hematologic-Meg-ery-Cycling_definitive_erythroblast|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

SPTA1 DNAJC6 TPX2 MKI67 OSBP2 AMMECR1 SKA1

6.37e-07176124798814f0a67411b2f7b25dc489b2aadb77f45a853
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NSD2 MYEF2 BRCA1 TPX2 MKI67 SKA1 PLK4

7.41e-0718012475e1680088065be14447d5d5465f91f7edd071a1e
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

7.41e-071801247f8a15c13d85c1bbbf86ce49bb6f86c368ddf22df
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTA1 MDGA2 CSMD3 GALNT13 XIRP2 PTPRQ KCNQ2

8.58e-0718412472cbed6462fea2622871bb7e49b0df3d984239281
ToppCelldroplet-Spleen-nan-24m-Lymphocytic-immature_NKT_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NSD2 NBEA EFHB GUCY1B1 TPX2 MKI67 SKA1

8.58e-071841247b998803180322a5ea2b567928dea531c26816c3c
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTA1 MDGA2 CSMD3 GALNT13 XIRP2 PTPRQ KCNQ2

8.58e-071841247ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTA1 MDGA2 CSMD3 GALNT13 XIRP2 PTPRQ KCNQ2

8.58e-0718412472b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellBac-SEP-Lymphocyte-T_NK-T_NK_proliferative|Bac-SEP / Disease, Lineage and Cell Type

ANKRD20A3P BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

8.58e-071841247848d05afd5a2ef61fb8a09c0f5fa2a56fd5c160b
ToppCellCOVID-cycling-|COVID / Condition, Cell_class and T cell subcluster

SPTA1 BRCA2 TPX2 MKI67 OSBP2 SKA1 SMC1B

8.90e-071851247eb74b8d36f7b749e04bc2ed4b36f7e1ac7bb6d5f
ToppCellControl-T_cells-Cycling_NK/T_cells|Control / group, cell type (main and fine annotations)

NSD2 LBR BRCA1 BRCA2 TPX2 MKI67 PLK4

8.90e-0718512479766216b41ee62bbac4caa25cb98ec5627a24075
ToppCellCOVID-cycling|COVID / Condition, Cell_class and T cell subcluster

SPTA1 BRCA2 TPX2 MKI67 OSBP2 SKA1 SMC1B

8.90e-0718512475112f966735fa48f0606adcfd5c0212ad5d3d77a
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Hematopoietic|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SPTA1 XIRP2 GUCY1B1 TPX2 MKI67 OSBP2 FRMD3

9.57e-07187124746e15419e80bd7180f3171a99d845b01bb635e53
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Hematopoietic-Megakaryocytic-Megakaryocyte|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SPTA1 XIRP2 GUCY1B1 TPX2 MKI67 OSBP2 FRMD3

9.57e-0718712470d17b07770e4c881a7ca53a5bd42471457d198fb
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Hematopoietic-Megakaryocytic|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SPTA1 XIRP2 GUCY1B1 TPX2 MKI67 OSBP2 FRMD3

9.57e-07187124769068480f6819a6c8560ecbb05deb156b4055e12
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SPTA1 XIRP2 GUCY1B1 TPX2 MKI67 OSBP2 FRMD3

9.57e-0718712479c8b932a15b8b50982cba4cf8db750e257eb9503
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

9.57e-0718712479351fa87b69a951af85b10bf91fe9b1cce8c0517
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

9.57e-071871247057569c9437219ecc396aa6e673b1178a2273837
ToppCellP03-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ABRA MYOM1 PDGFRL RRAD ITGA7 ADCY3 GUCY1B1

1.03e-061891247b5439ef221106f6d54434f268485e9bb17b39102
ToppCell10x5'-lymph-node_spleen-Lymphocytic_NK-Cycling_NK|lymph-node_spleen / Manually curated celltypes from each tissue

BRCA1 TPX2 MKI67 AKR1C3 SKA1 PLK4 SMC1B

1.06e-061901247451eaceb0cb0ec6cfcae00253c0e5c92a168c2f3
ToppCellMild-T/NK_proliferative|World / Disease group and Cell class

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.10e-0619112479dba5526fd5ea8065ad305feb2ee562335f887c6
ToppCelldroplet-Spleen-SPLEEN-30m-Lymphocytic-immature_NKT_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NSD2 BRCA1 GUCY1B1 TPX2 MKI67 SKA1 PLK4

1.10e-061911247c8b99bd3a30c81ee4deba9cbf0196920ab3ab550
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABRA MYH4 MYOM1 CMYA5 ITGA7 XIRP2 GUCY1B1

1.10e-061911247f932980baa032748857cb367a55c37dd975c693e
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

MYOM1 DGKD CMYA5 MAST4 DCP1B XIRP2 XPR1

1.18e-061931247dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.22e-061941247f39a471293ecc5c5967b00e772b8f48ebc9affbe
ToppCell3'_v3-blood-Lymphocytic_NK-Cycling_NK|blood / Manually curated celltypes from each tissue

BRCA1 BRCA2 TPX2 MKI67 AKR1C3 SKA1 PLK4

1.22e-061941247bf9734abaad603ade2a6a6940918aaf1e1c4e2cd
ToppCellControl-Lymphoid_T/NK-T/NK_proliferative|Control / Disease group, lineage and cell class

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.22e-0619412479bbb124001fba7450f4639f47f9b720a483e7242
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NSD2 BRCA1 TPX2 MKI67 SKA1 PLK4 SMC1B

1.22e-0619412476cc689595a182fbf685fa2f3b9c300f7170fb81f
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.22e-061941247a75ecd0b0a928d4646602f7d16a645f6b3df3af5
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.22e-06194124717744fd6645cf5a447a01a83f07e8d305c2bcd9c
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.22e-061941247e14f66f7584909621b776292fbd52808273fd2ee
ToppCelldroplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DMXL2 NSD2 BRCA1 TPX2 MKI67 SKA1 PLK4

1.27e-061951247c1435e61e4f0cf457f26ae436936048932ceb0db
ToppCellCOVID-19-T_cells-Cycling_NK/T_cells|COVID-19 / group, cell type (main and fine annotations)

NSD2 SPTA1 BRCA1 BRCA2 TPX2 MKI67 PLK4

1.27e-061951247764ed100c28d9bc93ee5ecabc5291c8f184d78da
ToppCellmild-Lymphocytic-Prol._cells|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.27e-0619512479a8cc9097a349fd0a53ccf2723ee8bb1418d6aca
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_cycling|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.31e-0619612471d2e0b328eb822db7521b5f5724d4bd17c0bad5f
ToppCellmild-Lymphocytic-Prol._cells|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.31e-061961247b1d9866d5dfaefdb8bedaf01a750d97987acb3d1
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.35e-0619712474b13335a43b9d6abc8e542e72440da7feb82fbe6
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic-lymphocyte-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.35e-06197124721861d8b389fafbdb7c3499684c9b6deee3dbd5e
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic-lymphocyte|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.35e-061971247ffb004c37cdd26cb7cdcd80f769a2eded65416dc
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_NK-Cycling_NK|lymph-node_spleen / Manually curated celltypes from each tissue

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.40e-061981247b2868a897dd96494cf1829c30e0ce508f52efdf3
ToppCellsevere-Lymphocytic-Prol._cells|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.40e-0619812474d8591eabb543ed789f963b507a07c560c76a7c9
ToppCell3'_v3-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-1|bone_marrow / Manually curated celltypes from each tissue

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.40e-0619812475c92687b853ebb00960adbef6552f9d460bc6886
ToppCell(0)_NK_Dividing|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4 SMC1B

1.40e-0619812475ebb4965b723302152b42bfaf48bb77a57dd02c5
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.45e-06199124711c3d9fe811a4619347f47d2b0e94066e3085625
ToppCellVE-cycling|VE / Condition, Cell_class and T cell subcluster

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.45e-06199124747c47ebc318a0b98841ca2656837bbd068899559
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.45e-06199124736c80907b2ec1cbcd1b4e841e6c02a4792591d74
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.45e-061991247bf4c31902ae8358215245a2e11b5a2fe4ca1bc8c
ToppCellCOVID-19_Mild-Lymphoid_T/NK-T/NK_proliferative|COVID-19_Mild / Disease group, lineage and cell class

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.45e-061991247ddea0e5c1cb6a096ab8e09a8c3c37c1bff381d9c
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

TGFBR3 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.45e-061991247101f78fe6dd1bf9e2e4dd5ad8a970312b3540927
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.45e-0619912477beb0e07a27fea94674f24eb61c381b0de38ed3e
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TGFBR3 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.45e-061991247e0fcec796afe75e42467ca86355b9fc5aa9ae0a1
ToppCellCOVID-19_Mild-T/NK_proliferative|COVID-19_Mild / Disease condition and Cell class

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.45e-0619912479f9a88d2b099646c1e1a7ee3f8d39cb1a2498ad7
ToppCellInfluenza_Severe-T/NK_proliferative|Influenza_Severe / Disease group and Cell class

BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4 SMC1B

1.45e-0619912472508c55f9ffe17b694c70f1283f41ad4a8e83c00
ToppCellVE-cycling-|VE / Condition, Cell_class and T cell subcluster

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.45e-061991247c0a67149a19b65b3069dbc5261d81f658e6e39a2
ToppCellLPS_IL1RA-Endothelial-Endothelial-FOXM1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.45e-061991247be2276c9a1994579ba1d2998b49bf549c1324d44
ToppCellMild-T/NK_proliferative|Mild / Disease group and Cell class

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.45e-06199124764a5c91243ee999ea21ffddd450d3e5fdbf6470b
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-FOXM1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

NSD2 LBR BRCA1 BRCA2 TPX2 MKI67 PLK4

1.50e-0620012474cfe08878a6981bf7b3567f9e82192d8f060ddde
ToppCellLung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-2,_SCARA5-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CFH BOC PAPPA2 PDGFRL AKR1C1 IGSF10 CSGALNACT1

1.50e-0620012470b2614b8513693dd508c9003699049efd9abac52
ToppCellLung_Parenchyma-Severe-Hematopoietic-RBC-RBC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

SPTA1 DNAJC6 GSPT1 TPX2 MKI67 OSBP2 SKA1

1.50e-062001247b5f2892bc45fda5ae05e269b840305a608a07c37
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Stem_cells-Neuroepithelial_cell|2m / Sample Type, Dataset, Time_group, and Cell type.

LBR BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.50e-0620012470d9b8d51a7630e70e60c76c763ff82df4c559152
ToppCellControl_saline-Endothelial-Endothelial-FOXM1|Control_saline / Treatment groups by lineage, cell group, cell type

NSD2 LBR BRCA1 BRCA2 TPX2 MKI67 PLK4

1.50e-0620012479bbc7b5561151f6ff65f40b3226271def732e5d9
ToppCellLung_Parenchyma-Severe-Hematopoietic-RBC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

SPTA1 DNAJC6 GSPT1 TPX2 MKI67 OSBP2 SKA1

1.50e-0620012479ce1f91991637fc3af0f6a80a85e1a44276fe412
ToppCellhealthy_donor-Lymphocytic-Proliferative_Lymphocyte|healthy_donor / Disease condition, Lineage, Cell class and subclass

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.50e-062001247e4eb915c29909cf8535a3603c68976545c05e54b
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Stem_cells|2m / Sample Type, Dataset, Time_group, and Cell type.

LBR BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.50e-0620012470675f580ccef705875854247bbfd4ee2bcf126a1
ToppCellLung_Parenchyma-Severe-Hematopoietic|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

SPTA1 DNAJC6 GSPT1 TPX2 MKI67 OSBP2 SKA1

1.50e-062001247fdf3e60cf94f398a56c0fa72813d0459f5ce081b
ToppCellLung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-2,_SCARA5|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

CFH BOC PAPPA2 PDGFRL AKR1C1 IGSF10 CSGALNACT1

1.50e-0620012478d2ceb2080c67b20f452eeca605aa27a58033c04
ToppCellSepsis-Bac-SEP-Lymphocyte-T/NK-T/NK_proliferative|Bac-SEP / Disease, condition lineage and cell class

ANKRD20A3P BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.50e-062001247a09b4e07b273880e94032b939ab191caaf6d656e
ToppCellhealthy_donor-Lymphocytic-Proliferative_Lymphocyte-|healthy_donor / Disease condition, Lineage, Cell class and subclass

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.50e-062001247415e7556b5ac45688e2c6c30a52bd40e0eb27c7d
ToppCellCOVID_non-vent-Lymphocytic-Proliferative_Lymphocyte-|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.50e-06200124704bf9e6a0fbd792b49eed63dabba5d6fafed8c07
ToppCellLung_Parenchyma-Severe-Hematopoietic-RBC-RBC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SPTA1 DNAJC6 GSPT1 TPX2 MKI67 OSBP2 SKA1

1.50e-062001247199165be1aef8497af71b74690a11de18fbe073c
ToppCellCOVID_vent-Lymphocytic-Proliferative_Lymphocyte-|COVID_vent / Disease condition, Lineage, Cell class and subclass

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.50e-0620012477e4c0db43a03ca11380a54f44a3cf1991e055b80
ToppCellCOVID_non-vent-Lymphocytic-Proliferative_Lymphocyte|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.50e-062001247f6b5320cdfe640a71e6e2df26f30d42e64b1c921
ToppCellInfluenza-Influenza_Severe-Lymphocyte-T/NK-T/NK_proliferative|Influenza_Severe / Disease, condition lineage and cell class

BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4 SMC1B

1.50e-062001247e1c266525ce6b42a4451b6a3b0cabf41ff5e2ee7
ToppCellParenchyma_COVID-19-Stromal-TX-Erythrocytes|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

SPTA1 DNAJC6 GSPT1 TPX2 MKI67 OSBP2 SKA1

1.50e-062001247a9edac2f5e009662df452ec032a80e855cdac28f
ToppCellParenchyma_COVID-19-Stromal-TX-Fibroblasts-2,_SCARA5|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

CFH BOC PAPPA2 PDGFRL AKR1C1 IGSF10 CSGALNACT1

1.50e-062001247c338a08c1605527ab9aaf62ea151a19e8469dc6d
ToppCellCOVID_vent-Lymphocytic-Proliferative_Lymphocyte|COVID_vent / Disease condition, Lineage, Cell class and subclass

NSD2 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.50e-0620012479775ca7dedb76fcbb74f80f86b33c94e394c320a
ToppCellmild-T/NK_proliferative|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TGFBR3 BRCA1 BRCA2 TPX2 MKI67 SKA1 PLK4

1.50e-06200124763cc57b9331459efbb73051d174d198a3568b938
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BRCA1 BRCA2 TPX2 MKI67 PLK4 ANKRD20A1

7.43e-06167124650c29ea660bf07b890e4ac1a1985d0761d863dee
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RAB35 DGKD LBR DCP1B TPX2 MKI67

7.43e-061671246754e6412d3b9cc0b126e59593df2f5956b4712ef
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MYH4 MYH8 MYOM1 CMYA5 XIRP2 PTPRQ

7.43e-061671246d78356bf0c473816dbabaee51984940bd822f84e
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BRCA1 BRCA2 TPX2 MKI67 PLK4 ANKRD20A1

7.69e-061681246d35944fd9fea9934ce1e76b2b35d48e2300cca61
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NSD2 BRCA1 BRCA2 TPX2 MKI67 PLK4

7.95e-0616912460bc8ef341ce307b19018d4ac8de0a4d04254209d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NSD2 ANKRD20A2P ADCY3 BRCA1 BRCA2 TPX2

7.95e-061691246e7514956b2e4298222ec443f98b2f5289451786e
ToppCell367C-Lymphocytic-CD4_T-cell-Proliferating_T_cell|367C / Donor, Lineage, Cell class and subclass (all cells)

BRCA1 TPX2 MKI67 SKA1 PLK4 SMC1B

8.80e-0617212468d20eda599abf1e9e3e3b90f314acddee6a465a4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_G2M|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NSD2 BRCA2 TPX2 MKI67 SKA1 PLK4

9.71e-061751246876cea684faf42ff3eb4623ad6d7a1fb1276ee02
ToppCell367C-Myeloid-Dendritic-cDC_proliferating_1|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

BRCA2 TPX2 MKI67 SKA1 PLK4 SMC1B

9.71e-0617512466b4e841bde6cfa4956e1a0231672cea20f11210c
ToppCellfacs-Heart-RV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BOC PCDHGA4 SLC25A33 ITGA7 DNAJC6 SLC12A2

1.04e-0517712467c3d46ebd7e8726be6871aa9763e281fc0ec6ac8
ToppCellfacs-Heart-RV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BOC PCDHGA4 SLC25A33 ITGA7 DNAJC6 SLC12A2

1.04e-051771246e7b1f3092e6b8d0d580f82648035f5ad12be6961
ToppCell367C-Myeloid-Dendritic-cDC_proliferating_1|367C / Donor, Lineage, Cell class and subclass (all cells)

BRCA2 TPX2 MKI67 SKA1 PLK4 SMC1B

1.04e-051771246ba701d3c90722d8bff70d0fa651899305cdad257
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH MYO1E CMYA5 TGFBR3 PTPRQ FRMD3

1.10e-0517912467394e77e665bf16d3733df91bb12907be460ab44
ToppCelldroplet-Spleen-nan-3m-Lymphocytic-immature_NKT_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BOC BRCA1 TPX2 MKI67 SKA1 PLK4

1.10e-05179124654621d2b3a66e62aa76b7e444118878ed97c1e02
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NSD2 BRCA1 TPX2 MKI67 SKA1 PLK4

1.10e-05179124654191c00b29f53b520cd3243b5791daa4a2c72d7
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NSD2 BRCA1 BRCA2 MKI67 SKA1 PLK4

1.10e-05179124688d44b04eb5c079531db663ed98ddb20b60feb9a
Drugcloxazolam

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.85e-1041224ctd:C005522
DrugPregnanes

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.85e-1041224ctd:D011278
Drugtetralol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.85e-1041224ctd:C019106
Drug3',3'',5',5''-tetrabromophenolphthalein

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.85e-1041224ctd:C018156
DrugHydroxysteroids

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.91e-0951224ctd:D006914
Drugcresolphthalein

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.91e-0951224ctd:C010092
DrugMedazepam

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.17e-0861224ctd:D008472
DrugNitrazepam

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.40e-0881224ctd:D009567
Drug4-hydroxybenzoic acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.68e-0891224ctd:C038193
Drug20-alpha-Dihydroprogesterone

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.68e-0891224ctd:D004092
Drugcyclopentanol

AKR1C1 AKR1C2 AKR1C3

1.50e-0731223ctd:C016327
Drugcyclopentanone

AKR1C1 AKR1C2 AKR1C3

1.50e-0731223ctd:C007201
Drug5-dihydrodeoxycorticosterone

AKR1C4 AKR1C1 AKR1C2

1.50e-0731223ctd:C454687
Drug4-benzoylbenzoic acid

AKR1C1 AKR1C2 AKR1C3

1.50e-0731223ctd:C058818
Drugdichloro(4-cymene)ruthenium(II)

AKR1C1 AKR1C2 AKR1C3

1.50e-0731223ctd:C530610
Drugoctyl gallate

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.61e-07101224ctd:C016627
DrugDihydroxydihydrobenzopyrenes

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.52e-07111224ctd:D004101
Drugchlordecone alcohol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.52e-07111224CID000013946
DrugPhenolphthalein

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.76e-07121224ctd:D020113
DrugDMBA-3,4-dihydrodiol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.40e-07131224CID000050096
Drugflunisolide

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.40e-07131224ctd:C007734
Drugtetrahydrodeoxycorticosterone

AKR1C4 AKR1C1 AKR1C2

5.98e-0741223ctd:C009413
Druggliquidone

AKR1C1 AKR1C2 AKR1C3

5.98e-0741223ctd:C010969
DrugDBD-H

AKR1C4 AKR1C1 AKR1C3

5.98e-0741223CID000131382
Drug5-alpha-Dihydroprogesterone

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.54e-07141224ctd:D043582
Drug1-acenaphthenol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.54e-07141224CID000022750
DrugMeclofenamic Acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.54e-07141224ctd:D008469
DrugNSC86000

AKR1C1 AKR1C2 AKR1C3

1.49e-0651223CID000257630
Drugoxcarbazepine

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.86e-06191224ctd:C036006
DrugAC1L93E5

AKR1C4 AKR1C1 AKR1C3

2.97e-0661223CID000412383
DrugEstazolam

AKR1C1 AKR1C2 AKR1C3

2.97e-0661223ctd:D004949
Drug3-hydroxyhexobarbital

AKR1C4 AKR1C2 AKR1C3

2.97e-0661223CID000439898
DrugGlipizide

AKR1C1 AKR1C2 AKR1C3

2.97e-0661223ctd:D005913
Drugacenaphthene-1-ol

AKR1C1 AKR1C2 AKR1C3

2.97e-0661223ctd:C023723
Drugbenzo(a)pyrene-7,8-dione

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.56e-06201224ctd:C076588
DrugChrysenes

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.56e-06201224ctd:D002911
DrugFlunitrazepam

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.38e-06211224ctd:D005445
Drug4-hydroxyequilenin-o-quinone

AKR1C1 AKR1C2 AKR1C3

5.17e-0671223ctd:C117714
Drugzomepirac

AKR1C1 AKR1C2 AKR1C3

5.17e-0671223ctd:C020549
Drugbenzene dihydrodiol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.33e-06221224CID000000418
DrugGlycyrrhetinic Acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.67e-06241224ctd:D006034
Drug2-cyclohexen-1-ol

AKR1C4 AKR1C2 AKR1C3

8.24e-0681223CID000013198
Drug9,10-phenanthrenequinone

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.10e-06251224ctd:C005399
DrugPregnanolone

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.10e-06251224ctd:D011280
DrugReserpinic acid hydrochloride; Down 200; 9.2uM; MCF7; HT_HG-U133A

RAB35 LZTR1 NSD2 ADCY3 STX1A C5 PLK4 SLC26A6

1.17e-0519812287323_DN
Drugbenzo(a)pyrene 7,8-dihydrodiol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.21e-05311224ctd:C017228
Drugflufenamic acid

PAPPA2 AKR1C4 MAP3K12 AKR1C1 AKR1C2 AKR1C3

2.56e-051081226CID000003371
Drugalpha-methylcinnamic acid

AKR1C1 AKR1C3

2.85e-0521222ctd:C510582
Drug(10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE

AKR1C1 AKR1C2

2.85e-0521222DB07768
Drugbaccharin

AKR1C2 AKR1C3

2.85e-0521222ctd:C012764
Drugchlordecone

AKR1C4 AKR1C1 AKR1C2 GSDME AKR1C3

3.01e-05671225CID000000299
Drugfenamic acid

AKR1C1 AKR1C2 AKR1C3

3.19e-05121223ctd:C001209
Drugmethylparaoxon

AKR1C1 AKR1C2 MKI67

3.19e-05121223ctd:C008480
Drugolaparib

MSH3 BRCA1 BRCA2

3.19e-05121223ctd:C531550
Drugblebbistatin

MYH4 WASL MYH8 MYO1E ACTR3 SLC12A2

3.84e-051161226CID003476986
Drug4-formyl-benzoate

AKR1C4 AKR1C1 AKR1C2

4.13e-05131223CID000012088
DrugDiazepam

AKR1C4 AKR1C1 AKR1C2 TGFBR3 AKR1C3

4.88e-05741225ctd:D003975
DrugDydrogesterone

AKR1C1 AKR1C2 AKR1C3

5.23e-05141223ctd:D004394
Drug6-.beta.-Naltrexol

AKR1C4 AKR1C1 AKR1C2

5.23e-05141223CID000631219
DrugAC1L1BWR

SPG7 BRCA1 BRCA2 CLTB AKR1C3

5.55e-05761225CID000001642
Drug20 alpha-dihydroprogesterone

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.18e-05401224CID000008956
Drugdrospirenone

AKR1C4 AKR1C1 AKR1C2

6.52e-05151223ctd:C035144
Drugo-quinone

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.82e-05411224CID000011421
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT_HG-U133A

PDGFRL CLIP2 NBEA ITGA7 DNAJC6 MAP3K12 BTRC

7.78e-0519112272137_UP
Drug9-cis-retinal

AKR1C4 AKR1C1 AKR1C3

7.99e-05161223ctd:C031390
DrugResveratrol [501-36-0]; Down 200; 17.6uM; MCF7; HT_HG-U133A

RAB35 KAT5 MSH3 ADCY3 STX1A MKI67 BTRC

8.04e-0519212272865_DN
DrugMefenamic acid [61-68-7]; Down 200; 16.6uM; PC3; HT_HG-U133A

LZTR1 MAP3K12 STX1A BRCA1 BRCA2 GUCY1B1 DZIP3

9.15e-0519612271821_DN
DrugPNU-0230031 [267429-39-0]; Down 200; 10uM; MCF7; HT_HG-U133A

PAPPA2 RAB35 RAB3D GSPT1 DZIP3 PLK4 BTRC

9.44e-0519712273629_DN
DrugCephapirin sodium salt [24356-60-3]; Up 200; 9uM; PC3; HT_HG-U133A

RAB35 WDR4 NSD2 MAST4 AKR1C3 PLK4 BTRC

9.44e-0519712277142_UP
Drugbenzo(a)pyrene-1,6-quinone

AKR1C1 AKR1C2 AKR1C3

9.66e-05171223ctd:C030233
Drugarachidonic acid sodium salt; Up 200; 10uM; MCF7; HG-U133A

LZTR1 SASH1 DHX38 RAB3D TRIP11 BRCA1 CLTB

9.75e-051981227443_UP
DrugFlufenamic Acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.86e-05451224ctd:D005439
DrugAC1L9IXX

MSH3 FAIM UXT GFM1

9.86e-05451224CID000446000
Drugnaphthalene-1,2-dihydrodiol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.86e-05451224CID000000362
Drughaloperidol; Down 200; 10uM; MCF7; HT_HG-U133A

RAB35 LZTR1 DHX38 DGKD MAP3K12 BRCA2 AKR1C3

1.01e-0419912276963_DN
Drugchlorpropamide; Down 200; 100uM; MCF7; HG-U133A

EPRS1 RAB35 DMXL2 CALU LONP1 STX1A PPME1

1.04e-042001227141_DN
Drugcloxazolam

AKR1C1 AKR1C2 AKR1C3

1.15e-04181223CID000002816
DrugRuthenium Compounds

AKR1C1 AKR1C2 AKR1C3

1.15e-04181223ctd:D017975
Drugbenzo(a)pyrene-3,6-quinone

AKR1C1 AKR1C2 AKR1C3

1.15e-04181223ctd:C018003
DrugFlavonoids

MYH8 CLIP2 LBR ITGA7 ACTR3 MPRIP TGFBR3 TGM1 STX1A SLC12A2 BRCA1 PTPRQ PRKAG1 PCYT2 POLR1B GFM1 RAB3B

1.19e-04113612217ctd:D005419
DrugKU55933

KAT5 RRAD BRCA1 SMC1B

1.27e-04481224CID005278396
DrugAC1L8ZBW

AKR1C4 AKR1C1 AKR1C2

1.37e-04191223CID000435356
Drugandrostane-3,17-dione

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.61e-04511224CID000000443
DrugPolymyxin M

BOC MSH3

1.70e-0441222CID000197072
DrugLY254155

CALU TGM1 XPR1

1.86e-04211223CID009803760
Drugconiferaldehyde

AKR1C1 AKR1C2 AKR1C3

1.86e-04211223ctd:C075384
DrugDutasteride

AKR1C1 AKR1C2 AKR1C3

1.86e-04211223ctd:D000068538
DrugDb04047

ABRA RRAD MKI67

1.86e-04211223CID000151434
DrugHexestrol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.17e-04551224ctd:D006589
Drug3-hydroxyandrostan-17-one

AKR1C4 AKR1C1 AKR1C2 AKR1C3 XPR1

2.24e-041021225CID000000225
Drug2'-Monophosphoadenosine 5'-Diphosphoribose

AKR1C1 AKR1C2 AKR1C3

2.46e-04231223DB03461
Drug1,2-dihydroxynaphthalene

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.49e-04571224CID000011318
Drugphenolphthalein

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.66e-04581224CID000004764
DrugNSC36919

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.66e-04581224CID000235496
Drugmedazepam

AKR1C1 AKR1C2 AKR1C3

2.80e-04241223CID000004041
Drugfarnesal

AKR1C2 AKR1C3

2.82e-0451222ctd:C084519
DrugNSC9700

BOC MYH4 MYH8 CLIP2 AKR1C4 AKR1C1 ADCY3 AKR1C2 GSDME AKR1C3 POLR1B

2.83e-0457812211CID000005408
Drugtricarballylate

BOC ABRA EPRS1 NSD2

2.84e-04591224CID000014925
DiseaseNeoplasms, Hormone-Dependent

AKR1C1 AKR1C2 AKR1C3

6.23e-0831183C0027661
DiseaseHermaphroditism

AKR1C1 AKR1C2 AKR1C3

6.20e-0751183C0019269
DiseaseAmbiguous Genitalia

AKR1C1 AKR1C2 AKR1C3

6.20e-0751183C0266362
DiseasePseudohermaphroditism

AKR1C1 AKR1C2 AKR1C3

6.20e-0751183C0033804
DiseaseIntersex Conditions

AKR1C1 AKR1C2 AKR1C3

6.20e-0751183C2930618
DiseaseSex Differentiation Disorders

AKR1C1 AKR1C2 AKR1C3

6.20e-0751183C2930619
DiseaseDisorders of Sex Development

AKR1C1 AKR1C2 AKR1C3

2.16e-0671183C0036875
Diseasecolorectal carcinoma (is_marker_for)

CALU ACTR3 BRCA1 BRCA2

1.45e-05371184DOID:0080199 (is_marker_for)
DiseaseMALE PSEUDOHERMAPHRODITISM: DEFICIENCY OF TESTICULAR 17,20-DESMOLASE

AKR1C4 AKR1C2

1.59e-0521182C1839840
Diseaseductal carcinoma in situ (biomarker_via_orthology)

BRCA1 BRCA2

1.59e-0521182DOID:0060074 (biomarker_via_orthology)
Disease46,XY disorder of sex development due to testicular 17,20-desmolase deficiency

AKR1C4 AKR1C2

1.59e-0521182cv:C1839840
DiseaseHereditary site-specific ovarian cancer syndrome

BRCA1 BRCA2

1.59e-0521182C4749652
Disease46,XY sex reversal 8 (is_implicated_in)

AKR1C4 AKR1C2

1.59e-0521182DOID:0111773 (is_implicated_in)
Disease46,XY SEX REVERSAL 8

AKR1C4 AKR1C2

1.59e-0521182614279
DiseaseC5a anaphylatoxin measurement

CFH C5

4.74e-0531182EFO_0020208
Diseasebrother of CDO measurement

CFH BOC

4.74e-0531182EFO_0020194
DiseaseHereditary breast ovarian cancer syndrome

BRCA1 BRCA2

9.46e-0541182cv:C0677776
DiseaseDwarfism

WDR4 AMMECR1 PLK4

1.34e-04251183C0013336
Diseasehereditary breast ovarian cancer syndrome (is_implicated_in)

BRCA1 BRCA2

1.57e-0451182DOID:5683 (is_implicated_in)
Diseasecortolone glucuronide (1) measurement

AKR1C2 AKR1C3

2.35e-0461182EFO_0800552
DiseaseAdult only

BRCA1 BRCA2

2.35e-0461182C3842001
DiseaseNeoplastic Cell Transformation

NSD2 AKR1C1 AKR1C2 BRCA1 AKR1C3

2.46e-041391185C0007621
DiseaseHDL cholesterol change measurement, response to simvastatin, response to fenofibrate

MSH3 TGFBR3

4.37e-0481182EFO_0007805, GO_1901557, GO_1903491
DiseaseIntellectual Disability

WDR4 NSD2 NBEA YWHAG BRCA1 CTCF PCYT2 PHIP

4.46e-044471188C3714756
Diseaseepilepsy (implicated_via_orthology)

RAB3D ITGA7 SLC13A4 SLC12A2 RAB3B

5.12e-041631185DOID:1826 (implicated_via_orthology)
DiseasePancreatic carcinoma, familial

BRCA1 BRCA2

5.60e-0491182C2931038
DiseaseNeoplasm of uncertain or unknown behavior of breast

BRCA1 BRCA2 BTK

5.95e-04411183C0496956
DiseaseBreast adenocarcinoma

BRCA1 BRCA2 BTK

5.95e-04411183C0858252
Diseaseautosomal dominant hyaline body myopathy (implicated_via_orthology)

MYH4 MYH8

6.99e-04101182DOID:0111269 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2B3 (implicated_via_orthology)

MYH4 MYH8

6.99e-04101182DOID:0111602 (implicated_via_orthology)
Diseasedistal arthrogryposis type 1 (implicated_via_orthology)

MYH4 MYH8

6.99e-04101182DOID:0111596 (implicated_via_orthology)
Diseasedilated cardiomyopathy 1S (implicated_via_orthology)

MYH4 MYH8

6.99e-04101182DOID:0110454 (implicated_via_orthology)
Diseasecongenital myopathy 6 (implicated_via_orthology)

MYH4 MYH8

6.99e-04101182DOID:0080719 (implicated_via_orthology)
Diseaseinclusion body myositis (implicated_via_orthology)

MYH4 MYH8

6.99e-04101182DOID:3429 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2A (implicated_via_orthology)

MYH4 MYH8

6.99e-04101182DOID:0111605 (implicated_via_orthology)
Diseasefamilial hypertrophic cardiomyopathy (implicated_via_orthology)

MYH4 MYH8

6.99e-04101182DOID:0080326 (implicated_via_orthology)
DiseaseFanconi anemia (is_implicated_in)

BRCA1 BRCA2

6.99e-04101182DOID:13636 (is_implicated_in)
Diseasesusceptibility to measles measurement

PAPPA2 MYO1E XIRP2

1.00e-03491183EFO_0008414
DiseaseAbruptio Placentae

PDGFRL GALNT13

1.02e-03121182EFO_1001754
DiseaseMouth Diseases

BRCA1 HSPA14

1.02e-03121182C0026636
Diseasedistal myopathy (implicated_via_orthology)

MYH4 MYH8

1.02e-03121182DOID:11720 (implicated_via_orthology)
Diseasemyotonia congenita (implicated_via_orthology)

MYH4 MYH8

1.02e-03121182DOID:2106 (implicated_via_orthology)
DiseaseVaricose veins

SLC25A33 CMYA5 TGFBR3 SLC12A2 FZD2

1.09e-031931185HP_0002619
Diseaserestrictive cardiomyopathy (implicated_via_orthology)

MYH4 MYH8

1.20e-03131182DOID:397 (implicated_via_orthology)
DiseaseBenign tumor of pancreas

BRCA1 BRCA2

1.20e-03131182C0347284
DiseaseDEAFNESS, AUTOSOMAL RECESSIVE (disorder)

DMXL2 PTPRQ

1.20e-03131182C1846647
Diseaseabdominal fat cell number

RAB35 DNAJC13 MYO1E MAST4 XIRP2

1.23e-031981185EFO_0021534
Diseaseskin melanoma (is_implicated_in)

BRCA2 CTCF

1.40e-03141182DOID:8923 (is_implicated_in)
DiseaseC-C motif chemokine 19 measurement

CFH DNAJC13

1.40e-03141182EFO_0008047
Diseaseearly cardiac repolarization measurement

RAB3D AKR1C8

1.40e-03141182EFO_0004885
DiseaseHereditary Breast and Ovarian Cancer Syndrome

BRCA1 BRCA2

1.40e-03141182C0677776
Diseasedistal arthrogryposis (implicated_via_orthology)

MYH4 MYH8

1.61e-03151182DOID:0050646 (implicated_via_orthology)
DiseaseEndometrial Neoplasms

MSH3 AKR1C1 AKR1C3

1.64e-03581183C0014170
Diseaseresponse to methotrexate

AKR1C1 AKR1C2

1.83e-03161182GO_0031427
DiseaseAntibody Deficiency Syndrome

CFH C5

2.07e-03171182C0003257
Diseasebreast carcinoma (is_marker_for)

BRCA1 CTCF FZD2

2.37e-03661183DOID:3459 (is_marker_for)
Diseasestomach cancer (is_marker_for)

LZTR1 NBEA BRCA1 MKI67

2.58e-031421184DOID:10534 (is_marker_for)
DiseaseNoonan-Like Syndrome With Loose Anagen Hair

LZTR1 A2ML1

2.59e-03191182C3501846
DiseasePancreatic carcinoma

BRCA1 BRCA2

2.59e-03191182C0235974
DiseaseNoonan syndrome-like disorder with loose anagen hair

LZTR1 A2ML1

2.59e-03191182C1843181
DiseaseCardio-facio-cutaneous syndrome

LZTR1 A2ML1

2.59e-03191182C1275081
DiseaseCostello syndrome (disorder)

LZTR1 A2ML1

2.59e-03191182C0587248
DiseaseAdenocarcinoma of prostate

BRCA1 BRCA2

2.87e-03201182C0007112
Diseasecardiomyopathy (implicated_via_orthology)

MYH4 MYH8 ITGA7

2.92e-03711183DOID:0050700 (implicated_via_orthology)
DiseaseEndometrial Carcinoma

MSH3 AKR1C1 AKR1C3

3.04e-03721183C0476089
DiseaseBREAST CANCER

BRCA1 BRCA2

3.17e-03211182114480
Diseasesex interaction measurement, cerebral amyloid angiopathy

EFHB GALNT13

3.17e-03211182EFO_0006790, EFO_0008343
DiseaseNystagmus

MSH3 MAST4

3.17e-03211182HP_0000639
DiseaseSeckel syndrome

WDR4 PLK4

3.48e-03221182C0265202
DiseaseLEOPARD Syndrome

LZTR1 A2ML1

3.48e-03221182C0175704
Diseasecomplement factor H-like 1 protein measurement

CFH KCNQ2

3.48e-03221182EFO_0600092
DiseaseImmunologic Deficiency Syndromes

CFH C5

3.80e-03231182C0021051

Protein segments in the cluster

PeptideGeneStartEntry
EGYSVSREKKERFSL

TRBV28

81

A0A5B6
GVVSIKEDKYFQTSR

ANKRD20A1

806

Q5TYW2
EQKEEYRGRTTFVSK

BTN2A3P

86

Q96KV6
EKRATVVESSEKAYS

YWHAG

141

P61981
DGSVKREDIFYTSKL

AKR1C4

71

P17516
VDEKGRVVDIYSKFD

PRKAG1

231

P54619
KIADGTVKREEIFYT

AKR1C8

71

Q5T2L2
STYRDIVVKKEDGFT

CDY1

281

Q9Y6F8
GVVSIKEDKYFQTSR

ANKRD20A8P

806

Q5CZ79
KREGKSFIYQSEVSF

CSMD3

3301

Q7Z407
EESETFIKGKERKTY

CTCF

11

P49711
YGFKVEVEKESVLST

CARNMT1

371

Q8N4J0
TERDKGTLYELTFKG

CSGALNACT1

216

Q8TDX6
VRDSSKAGKYTVSVF

BTK

306

Q06187
DGSVKREDIFYTSKL

AKR1C3

71

P42330
VVVESDFVKYEGKFA

GSDME

71

O60443
DKYIVSASGDRTIKV

BTRC

436

Q9Y297
GYSDVKFTVTLETKD

A2ML1

46

A8K2U0
KTGVVRYVGETDFAK

CLIP2

231

Q9UDT6
TKEEIVDKYDLFVGS

CALU

286

O43852
KQKLYSRTGESVEFV

CFH

1186

P08603
AKETVTVGKDGTRDY

DMXL2

1406

Q8TDJ6
ETELREYFKKFGVVT

DAZAP1

126

Q96EP5
ERKVVETEDAYKFAG

RAB35

126

Q15286
FVSTVGIDFKVKTVY

RAB3B

51

P20337
FVSTVGIDFKVKTVY

RAB3D

51

O95716
KYVAKELAVRTFEVT

LBR

186

Q14739
ETGKDTFRVYKSGSE

PPME1

61

Q9Y570
VIVYSVTDKGSFEKA

RRAD

166

P55042
GVVSIKEDKYFQTSR

ANKRD20A2P

806

Q5SQ80
GDVTYSFRKVRDKIS

PCDHGA4

306

Q9Y5G9
AVTEFYAKDTVDIKG

MSH3

471

P20585
VRVESGYFSLEKTKQ

MPRIP

261

Q6WCQ1
EYVRLVTEFSKKTGD

NOB1

61

Q9ULX3
TYEERVGFKKSRDVF

LZTR1

351

Q8N653
FPEKEYEGEKVSVTT

LACTB

196

P83111
IEFSYELSKVEGKTG

KAT5

386

Q92993
AKTSVFVAEPKESYV

MYH8

36

P13535
ITLTVDGRDTYEEVK

PCYT2

116

Q99447
VFSTIKEYEKSSEGA

KCNQ2

111

O43526
SVEERKAKFTFLYVG

NSD2

336

O96028
SEDGYRTVVQGTKKE

FZD2

311

Q14332
RKSAYKIVSGEAESV

LONP1

721

P36776
TDSRKNPFVYKVETV

GUCY1B1

461

Q02153
GDFKEISSVKLVSRY

MKI67

201

P46013
KFSIDIETFYKTDAG

PITPNM2

106

Q9BZ72
SYFSKEAARKVTGVV

OSBP2

721

Q969R2
AGKVTTDYGETEKER

DZIP3

736

Q86Y13
KGKTVEVGRAYFETE

GSPT1

136

P15170
TKFGEGDSTIRVIKY

MDGA2

721

Q7Z553
TEGKTKFSGNEEIYI

PTPRQ

1871

Q9UMZ3
GVVKVDYGDVSVRKT

GALNT13

386

Q8IUC8
KVSGVKVYTFDERIE

PAPPA2

1016

Q9BXP8
SVESNIEDKIFGKTY

BRCA1

451

P38398
EKTDVEGTLFVYTRS

DCP1B

51

Q8IZD4
FRYSGKVAKEVVEAS

FRMD3

331

A2A2Y4
KETGTLYASKFEDVL

EBLN1

111

P0CF75
GVVSIKEDKYFQTSR

ANKRD20A3P

806

Q5VUR7
AISKKEFSIDVGYER

ACTR3

261

P61158
FIISKTTREDAGKYR

IGSF10

2396

Q6WRI0
YKLAEEVSGRTEVTV

IGSF3

796

O75054
VEITGLEKGTSYKFR

BOC

666

Q9BWV1
TTGTFVEEITENYKR

BRCA2

1301

P51587
KEDFSTTGTAYFEVK

C5

206

P01031
ISEVSREDYGKKEIS

CMYA5

2281

Q8N3K9
TSGKRVVYVDGKEEI

FAIM

26

Q9NVQ4
KGDLDFTYVTSRIIV

DNAJC6

61

O75061
FEDNIKISVYTGKSE

ADGRF2

166

Q8IZF7
EAISYVREKTKTGVD

ADCY3

396

O60266
RKGSITEYTAAEEKE

BNIP2

111

Q12982
IEFIKGQVRKYSSTE

DNAJC13

296

O75165
YDDVVKISDFGTSKE

MAP3K12

246

Q12852
VYPKAVERSSTFENK

MAST4

1576

O15021
ARVGKAYEKTTESSE

DGKD

516

Q16760
FGTAVIKEYSAKDVV

EFHB

386

Q8N7U6
SERDVGSKVKYEVTV

ITGA7

876

Q13683
KVYFDTENKETVISG

GFM1

481

Q96RP9
EKKGYRTDATVSVFL

SLC13A4

406

Q9UKG4
GKLRYEIDTGEETKF

HSPA14

96

Q0VDF9
KILEGTETTKYVFTD

MRPS22

146

P82650
TEKEKFAGGDYTTTI

EPRS1

1211

P07814
ETKDTKGRYFIVEAD

SKA1

201

Q96BD8
KGRYFIVEADIKEFT

SKA1

206

Q96BD8
EVTYVELFKDAEGKS

MYEF2

126

Q9P2K5
YSEAKEVRGVKVFRS

SLC26A6

531

Q9BXS9
YGTEEDVVKSKKTFR

NBEA

2101

Q8NFP9
FIDTETKKELLGSYV

PDIK1L

256

Q8N165
TYEVEKTLGIEAART

POLR3A

1251

O14802
TKVEVTEFEDIKSGY

SETSIP

131

P0DME0
EYKKGESQTDIEITR

CCT3

246

P49368
EIKKIGDEYFTFITD

CCT3

351

P49368
TSVFVVDPKESYVKA

MYH4

36

Q9Y623
YIDEIDAVGKKRSTT

SPG7

406

Q9UQ90
DEAKTGSTYIFFTEK

PDGFRL

156

Q15198
TEDFIQVIEKTGKSY

PLK4

736

O00444
VEKGFYTEKDASTLI

CAMK1D

111

Q8IU85
LREEGTKYKSFVQTA

SLC25A33

261

Q9BSK2
KTVVSKTYERGGDVS

ABRA

111

Q8N0Z2
DGSVKREDIFYTSKL

AKR1C1

71

Q04828
DGSVKREDIFYTSKL

AKR1C2

71

P52895
IEFINEKGSKRTATY

AMMECR1

241

Q9Y4X0
GYVASEEAFVKESKE

CLTB

171

P09497
KGVKATGTVREYRTE

PGBD2

366

Q6P3X8
DREGSYHEVTTVKKE

XIRP2

1151

A4UGR9
VTDEDTVKRYFAKFE

XPR1

41

Q9UBH6
KDQGKEYDGFTITIT

TTC13

681

Q8NBP0
EATGEKVLRYETFIS

UXT

11

Q9UBK9
TAKGEEEIKTYRSEE

PHIP

741

Q8WWQ0
VPTSKRETYTEDFIK

MRPS9

61

P82933
KIIYVEESGEEKTFA

SMC1B

81

Q8NDV3
VDYVERAVSDTKKAV

STX1A

241

Q16623
AVVTYTAESKGVVKF

SLC12A2

271

P55011
FSEDKTDKGIYVTRV

TAX1BP3

46

O14907
KVGTFKFIYVDVLSE

SASH1

601

O94885
VTEDGKVDYRTEQKF

DHX38

491

Q92620
KGVSEETLKEFSTIY

SPTA1

2266

P02549
EKIVETYRGKETEYQ

TRIP11

1466

Q15643
GSFKIVYVEEKAIGT

TGM1

511

P22735
KVLVADKSGDVYSFS

WDR4

116

P57081
TSKVIYDFIEKTGGV

WASL

251

O00401
GSVYKSEFIDLSEKI

POLR1B

771

Q9H9Y6
SIIKTYEIFETSDGR

TSSK2

71

Q96PF2
EITASAEKYVEKLFG

ZFC3H1

1236

O60293
KEYGAVTSFTELKIA

TGFBR3

166

Q03167
QGKKRTFDETVSTYV

TPX2

311

Q9ULW0
FADTVTKYDRRFKGV

MYO1E

766

Q12965
SVVVKRYKGEFDETR

MYOM1

366

P52179