Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium,bicarbonate:chloride antiporter activity	SLC4A10 SLC4A8	8.94e-06	3	35	2	GO:0140892
GeneOntologyMolecularFunction	sodium:bicarbonate symporter activity	SLC4A10 SLC4A8	4.46e-05	6	35	2	GO:0008510
GeneOntologyMolecularFunction	calcium-dependent phospholipid binding	ANXA8 ESYT1 ANXA8L1	1.58e-04	60	35	3	GO:0005544
GeneOntologyMolecularFunction	chloride:bicarbonate antiporter activity	SLC4A10 SLC4A8	2.30e-04	13	35	2	GO:0140900
GeneOntologyMolecularFunction	monoatomic cation:bicarbonate symporter activity	SLC4A10 SLC4A8	2.30e-04	13	35	2	GO:0140410
GeneOntologyMolecularFunction	bicarbonate:monoatomic anion antiporter activity	SLC4A10 SLC4A8	2.30e-04	13	35	2	GO:0140829
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	SMARCA5 BTAF1 HELQ	1.42e-03	127	35	3	GO:0008094
GeneOntologyMolecularFunction	solute:inorganic anion antiporter activity	SLC4A10 SLC4A8	1.43e-03	32	35	2	GO:0005452
GeneOntologyMolecularFunction	bicarbonate transmembrane transporter activity	SLC4A10 SLC4A8	1.43e-03	32	35	2	GO:0015106
GeneOntologyMolecularFunction	phosphatidylinositol-3,4-bisphosphate binding	ANXA8 ANXA8L1	1.71e-03	35	35	2	GO:0043325
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	SMARCA5 BTAF1	1.91e-03	37	35	2	GO:0140658
GeneOntologyMolecularFunction	metal cation:monoatomic cation antiporter activity	SLC4A10 SLC4A8	2.58e-03	43	35	2	GO:0140828
GeneOntologyMolecularFunction	helicase activity	SMARCA5 BTAF1 HELQ	2.64e-03	158	35	3	GO:0004386
GeneOntologyMolecularFunction	phosphatidylinositol-3,4,5-trisphosphate binding	ANXA8 ANXA8L1	3.33e-03	49	35	2	GO:0005547
GeneOntologyMolecularFunction	ATP-dependent activity	SHOC1 SMARCA5 BTAF1 MYO1D HELQ	4.09e-03	614	35	5	GO:0140657
GeneOntologyBiologicalProcess	negative regulation of phospholipase A2 activity	ANXA8 ANXA8L1	7.90e-06	3	34	2	GO:1900138
GeneOntologyBiologicalProcess	negative regulation of phospholipase activity	ANXA8 ANXA8L1	2.63e-05	5	34	2	GO:0010519
GeneOntologyBiologicalProcess	negative regulation of serine-type peptidase activity	ANXA8 ANXA8L1	7.34e-05	8	34	2	GO:1902572
GeneOntologyBiologicalProcess	negative regulation of serine-type endopeptidase activity	ANXA8 ANXA8L1	7.34e-05	8	34	2	GO:1900004
GeneOntologyBiologicalProcess	regulation of serine-type peptidase activity	ANXA8 ANXA8L1	1.18e-04	10	34	2	GO:1902571
GeneOntologyBiologicalProcess	regulation of serine-type endopeptidase activity	ANXA8 ANXA8L1	1.18e-04	10	34	2	GO:1900003
GeneOntologyBiologicalProcess	regulation of phospholipase A2 activity	ANXA8 ANXA8L1	1.18e-04	10	34	2	GO:0032429
GeneOntologyBiologicalProcess	negative regulation of lipase activity	ANXA8 ANXA8L1	2.37e-04	14	34	2	GO:0060192
Domain	AnnexinVIII	ANXA8 ANXA8L1	3.22e-06	2	34	2	IPR009115
Domain	Na/HCO3_transpt	SLC4A10 SLC4A8	3.21e-05	5	34	2	IPR003024
Domain	ANION_EXCHANGER_2	SLC4A10 SLC4A8	6.72e-05	7	34	2	PS00220
Domain	ANION_EXCHANGER_1	SLC4A10 SLC4A8	6.72e-05	7	34	2	PS00219
Domain	Band3_cytoplasmic_dom	SLC4A10 SLC4A8	1.15e-04	9	34	2	IPR013769
Domain	Band_3_cyto	SLC4A10 SLC4A8	1.15e-04	9	34	2	PF07565
Domain	-	SLC4A10 SLC4A8	1.15e-04	9	34	2	3.40.1100.10
Domain	PTrfase/Anion_transptr	SLC4A10 SLC4A8	1.43e-04	10	34	2	IPR016152
Domain	HCO3_cotransp	SLC4A10 SLC4A8	1.43e-04	10	34	2	PF00955
Domain	HCO3_transpt_euk	SLC4A10 SLC4A8	1.43e-04	10	34	2	IPR003020
Domain	HCO3_transpt_C	SLC4A10 SLC4A8	1.43e-04	10	34	2	IPR011531
Domain	Annexin	ANXA8 ANXA8L1	2.48e-04	13	34	2	PF00191
Domain	ANX	ANXA8 ANXA8L1	2.48e-04	13	34	2	SM00335
Domain	ANNEXIN	ANXA8 ANXA8L1	2.48e-04	13	34	2	PS00223
Domain	Annexin_repeat	ANXA8 ANXA8L1	2.48e-04	13	34	2	IPR018502
Domain	-	ANXA8 ANXA8L1	2.48e-04	13	34	2	1.10.220.10
Domain	Annexin_repeat_CS	ANXA8 ANXA8L1	2.48e-04	13	34	2	IPR018252
Domain	Annexin	ANXA8 ANXA8L1	2.89e-04	14	34	2	IPR001464
Domain	Helicase_C	SMARCA5 BTAF1 HELQ	9.61e-04	107	34	3	PF00271
Domain	HELICc	SMARCA5 BTAF1 HELQ	9.61e-04	107	34	3	SM00490
Domain	Helicase_C	SMARCA5 BTAF1 HELQ	9.88e-04	108	34	3	IPR001650
Domain	HELICASE_CTER	SMARCA5 BTAF1 HELQ	1.01e-03	109	34	3	PS51194
Domain	HELICASE_ATP_BIND_1	SMARCA5 BTAF1 HELQ	1.01e-03	109	34	3	PS51192
Domain	DEXDc	SMARCA5 BTAF1 HELQ	1.01e-03	109	34	3	SM00487
Domain	Helicase_ATP-bd	SMARCA5 BTAF1 HELQ	1.04e-03	110	34	3	IPR014001
Domain	SNF2_N	SMARCA5 BTAF1	1.54e-03	32	34	2	PF00176
Domain	SNF2_N	SMARCA5 BTAF1	1.54e-03	32	34	2	IPR000330
Domain	Kelch-typ_b-propeller	KBTBD12 KLHL5	4.50e-03	55	34	2	IPR015915
Domain	Kelch	KBTBD12 KLHL5	4.99e-03	58	34	2	SM00612
Domain	BACK	KBTBD12 KLHL5	5.33e-03	60	34	2	SM00875
Domain	BACK	KBTBD12 KLHL5	5.50e-03	61	34	2	PF07707
Domain	BACK	KBTBD12 KLHL5	5.50e-03	61	34	2	IPR011705
Domain	Kelch_1	KBTBD12 KLHL5	7.19e-03	70	34	2	PF01344
Domain	Kelch_1	KBTBD12 KLHL5	7.19e-03	70	34	2	IPR006652
Domain	-	PSMD1 BTAF1 TTC12	7.56e-03	222	34	3	1.25.10.10
Domain	TPR_1	CDC16 TTC12	1.17e-02	90	34	2	PF00515
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A10 SLC4A8	1.70e-04	10	28	2	M27335
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A10 SLC4A8	1.70e-04	10	28	2	MM15073
Pathway	WP_15Q11Q13_COPY_NUMBER_VARIATION	APBA2 TRPM1 FANCI	2.12e-04	59	28	3	M48104
Pubmed	Annexins: linking Ca2+ signalling to membrane dynamics.	ANXA8 ANXA8L1	9.84e-07	2	35	2	15928709
Pubmed	TaqI polymorphisms at the annexin VIII locus (ANX8).	ANXA8 ANXA8L1	9.84e-07	2	35	2	1364010
Pubmed	Annexin A8 controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63.	ANXA8 ANXA8L1	9.84e-07	2	35	2	24769558
Pubmed	K+-Driven Cl-/HCO3- Exchange Mediated by Slc4a8 and Slc4a10.	SLC4A10 SLC4A8	9.84e-07	2	35	2	38674160
Pubmed	Annexins: from structure to function.	ANXA8 ANXA8L1	9.84e-07	2	35	2	11917092
Pubmed	Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes.	ANXA8 ANXA8L1	9.84e-07	2	35	2	29306076
Pubmed	Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium.	ANXA8 ANXA8L1	9.84e-07	2	35	2	25803307
Pubmed	Bone matrix regulates osteoclast differentiation and annexin A8 gene expression.	ANXA8 ANXA8L1	9.84e-07	2	35	2	21344395
Pubmed	Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer.	ANXA8 ANXA8L1	9.84e-07	2	35	2	16203777
Pubmed	Specific expression of annexin A8 in adult murine stratified epithelia.	ANXA8 ANXA8L1	2.95e-06	3	35	2	17082908
Pubmed	Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha.	ANXA8 ANXA8L1	2.95e-06	3	35	2	2530088
Pubmed	Immunocytochemical identification of electroneutral Na⁺-coupled HCO₃⁻ transporters in freshly dissociated mouse medullary raphé neurons.	SLC4A10 SLC4A8	9.82e-06	5	35	2	23500099
Pubmed	Localization of Cacna1s to ON bipolar dendritic tips requires mGluR6-related cascade elements.	CACNA1S TRPM1	1.47e-05	6	35	2	24519419
Pubmed	The genetic origin of mouse annexin VIII.	ANXA8 ANXA8L1	2.06e-05	7	35	2	9434938
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	PSMD1 SMARCA5 BTAF1 CDK12 FANCI CDC16	2.30e-05	582	35	6	20467437
Pubmed	Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).	BTAF1 FANCI CDC16	2.36e-05	55	35	3	27114453
Pubmed	DNA polymerase POLN participates in cross-link repair and homologous recombination.	HELQ FANCI	2.74e-05	8	35	2	19995904
Pubmed	Cdk12 is essential for embryonic development and the maintenance of genomic stability.	CDK12 FANCI	4.40e-05	10	35	2	26658019
Pubmed	De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair.	SMARCA5 CDK12	5.38e-05	11	35	2	31045206
Pubmed	The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins.	SMARCA5 FANCI	5.38e-05	11	35	2	24800743
Pubmed	HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.	HELQ FANCI	6.45e-05	12	35	2	24005329
Pubmed	Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex.	CDK12 FANCI	1.02e-04	15	35	2	27073218
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PSMD1 SETD2 SMARCA5 BTAF1 ODF2 CDK12	1.11e-04	774	35	6	15302935
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	APBA2 SLC4A10 PSMD1 ANXA8 SLC4A8 CDC16 ANXA8L1	1.19e-04	1139	35	7	36417873
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	PSMD1 SMARCA5 CDK12 FANCI CDC16	1.41e-04	503	35	5	16964243
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SLC4A8 MYO1D ESYT1	1.45e-04	101	35	3	9872452
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	PSMD1 ANKMY2 CDK12 FANCI ESYT1 CDS2	2.21e-04	878	35	6	37223481
Pubmed	Candidate downstream regulated genes of HOX group 13 transcription factors with and without monomeric DNA binding capability.	ANXA8 ANXA8L1	2.24e-04	22	35	2	15733672
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	PSMD1 SMARCA5 FANCI ESYT1 CDC16	2.32e-04	560	35	5	35241646
Pubmed	Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes.	APBA2 TRPM1	3.15e-04	26	35	2	16280085
Pubmed	Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease.	ANXA8 ANXA8L1	3.66e-04	28	35	2	33953184
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	PSMD1 SMARCA5 MYO1D FANCI ESYT1 CDC16 RGS22	4.69e-04	1425	35	7	30948266
Pubmed	The NANCI-Nkx2.1 gene duplex buffers Nkx2.1 expression to maintain lung development and homeostasis.	ANXA8 ANXA8L1	4.79e-04	32	35	2	28546511
Pubmed	Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells.	CACNA1S TRPM1	4.79e-04	32	35	2	25757744
Pubmed	Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.	SLC4A10 SLC4A8 RELL2 CDS2	7.13e-04	405	35	4	38187761
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SETD2 SMARCA5 ESYT1 CDC16	9.70e-04	440	35	4	34244565
Cytoband	10q11.22	ANXA8 ANXA8L1	4.54e-04	41	35	2	10q11.22
Cytoband	Ensembl 112 genes in cytogenetic band chr15q13	APBA2 TRPM1	2.67e-03	100	35	2	chr15q13
Cytoband	Ensembl 112 genes in cytogenetic band chr10q11	ANXA8 ANXA8L1	9.08e-03	188	35	2	chr10q11
GeneFamily	Annexins\|Endogenous ligands	ANXA8 ANXA8L1	1.92e-04	13	29	2	404
ToppCell	AT1-AT2_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	SHOC1 GPR176 FANCI ANXA8L1	7.04e-06	158	35	4	3bc51cfd37b289cc3e866b54ce55a298e5eff690
Disease	anemia (implicated_via_orthology)	SLC4A10 SLC4A8	1.34e-04	15	34	2	DOID:2355 (implicated_via_orthology)
Disease	Fanconi Anemia	FANCI MX1	3.80e-04	25	34	2	C0015625
Disease	lymphocyte percentage of leukocytes	CACNA1S PLAGL1 SETD2 MYO1D ASB3	9.27e-04	665	34	5	EFO_0007993
Disease	Leukemia, Myelocytic, Acute	SETD2 FANCI MX1	1.04e-03	173	34	3	C0023467
Disease	severe acute respiratory syndrome, COVID-19	SLC4A10 UNC13C TRPM1 HELQ	1.68e-03	447	34	4	EFO_0000694, MONDO_0100096
Disease	antisaccade response measurement	PLAGL1 UNC13C	1.91e-03	56	34	2	EFO_0006874
Disease	anorexia nervosa	MYO1D ASB3	2.96e-03	70	34	2	MONDO_0005351
Disease	neutrophil percentage of leukocytes	PLAGL1 SETD2 CLOCK ASB3	5.13e-03	610	34	4	EFO_0007990
Disease	smoking cessation	SLC4A8 CDK12 TTC12	6.15e-03	325	34	3	EFO_0004319
Disease	creatinine measurement, glomerular filtration rate	CACNA1S CDK12	8.05e-03	117	34	2	EFO_0004518, EFO_0005208
Disease	executive function measurement	SLC4A10 UNC13C ASB3	9.17e-03	376	34	3	EFO_0009332
Disease	monocyte percentage of leukocytes	PLAGL1 KLHL5 SETD2 CDC16	9.61e-03	731	34	4	EFO_0007989
Disease	verbal-numerical reasoning measurement	SLC4A10 WDR17	1.00e-02	131	34	2	EFO_0008394

Protein segments in the cluster

Peptide	Gene	Start	Entry
KKYFCKAGVKGMQLH	ESYT1	226	Q9BSJ8
KQLMEGLEYCHKKNF	CDK12	841	Q9NYV4
IGFCMFVLSLVKKHY	CDS2	176	O95674
QEGKKQYKMICHVFE	APBA2	491	Q99767
IDLNLIKCHFKKMYG	ANXA8	286	P13928
MCYKKLSDILNEKAG	FANCI	776	Q9NVI1
IYTMLFCKVVKFLHK	GPR176	111	Q14439
TFKKMENYLRHKQLC	KLHL5	206	Q96PQ7
GHCMYKAIEDQLKEK	OTUD6B	156	Q8N6M0
KLKCYDFDVHTMKTL	CDC16	541	Q13042
YIKMKTFEGFCALHL	ASB3	71	Q9Y575
ISKLKAHQMCFRDYK	GLP2R	366	O95838
IDLNLIKCHFKKMYG	ANXA8L1	286	Q5VT79
NKYKLHGILCDDMGL	BTAF1	1281	O14981
ELFKGKMHKTCYFIG	CACNA1S	216	Q13698
MHAAYKGKLDMCKLL	ANKMY2	51	Q8IV38
MICKFLSKEYLKHKE	HELQ	596	Q8TDG4
MECKIEGKEKYQHSL	KBTBD12	1	Q3ZCT8
GHCKMNRYDKKIDSL	ODF2	116	Q5BJF6
VGFMICHVLKKKGYR	RELL2	31	Q8NC24
CGKKYNTMLGYKRHL	PLAGL1	96	Q9UM63
RHLEKMKKCYLVSNG	RGS22	451	Q8NE09
KMFQRCLDDHKYKQA	PSMD1	136	Q99460
KHCKELNIPYMAFKV	SHOC1	826	Q5VXU9
NYCKGIMHLKHLIKF	WDR17	776	Q8IZU2
KKGCGYHLDLLMVAI	SLC4A8	816	Q2Y0W8
LAKCHEHLMQYGKGK	CLOCK	321	O15516
LCKSTDYMNLHFKVK	UNC13C	1651	Q8NB66
LKKGCGYHLDLLMVA	SLC4A10	846	Q6U841
KLTHGVMNKELKYCK	SETD2	2511	Q9BYW2
KALVACKLYKAMAHE	TRPM1	641	Q7Z4N2
EKCTKAYFHMGKANL	TTC12	171	Q9H892
ICMLHKLGFDKENVY	SMARCA5	956	O60264
NLVFHLKKGYMIVKC	MX1	266	P20591
KDKYMNVLFSCHVRK	MYO1D	851	O94832