Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbeta-adrenergic receptor kinase activity

GRK5 GRK2 GRK3

3.06e-0641843GO:0047696
GeneOntologyMolecularFunctionprotein kinase activity

DDR1 ATR GRK5 OBSCN BAZ1B YES1 MKNK1 PIKFYVE CCNH TGFBR3 LIMK1 GRK2 GRK3 BTK MAPK9 MAPK10 EPHA7 EPHA8

1.17e-0560018418GO:0004672
GeneOntologyMolecularFunctionG protein-coupled receptor kinase activity

GRK5 GRK2 GRK3

2.62e-0571843GO:0004703
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

DDR1 ATR GRK5 OBSCN BAZ1B YES1 MKNK1 PIKFYVE CCNH TGFBR3 LIMK1 PANK2 GRK2 GRK3 BTK MAPK9 MAPK10 EPHA7 EPHA8

3.16e-0570918419GO:0016773
GeneOntologyMolecularFunctionkinase activity

DDR1 ATR GRK5 OBSCN BAZ1B YES1 MKNK1 PIKFYVE CCNH TGFBR3 LIMK1 PANK2 GRK2 GRK3 BTK MAPK9 MAPK10 EPHA7 EPHA8

8.56e-0576418419GO:0016301
GeneOntologyMolecularFunctionJUN kinase activity

MAPK9 MAPK10

2.52e-0431842GO:0004705
DomainGPCR_kinase

GRK5 GRK2 GRK3

3.25e-0571853IPR000239
DomainDAD_dom

FHOD3 FMNL2 DIAPH3

5.16e-0581853IPR014767
DomainDAD

FHOD3 FMNL2 DIAPH3

5.16e-0581853PS51231
DomainWAC_Acf1_DNA_bd

BAZ1B BAZ1A

9.76e-0521852PF10537
DomainWAC

BAZ1B BAZ1A

9.76e-0521852PS51136
DomainWSTF_Acf1_Cbp146

BAZ1B BAZ1A

9.76e-0521852IPR013136
DomainGBD/FH3_dom

FHOD3 FMNL2 DIAPH3

1.49e-04111853IPR014768
DomainGBD_FH3

FHOD3 FMNL2 DIAPH3

1.49e-04111853PS51232
DomainKinase-like_dom

DDR1 ATR GRK5 OBSCN YES1 MKNK1 LIMK1 DST GRK2 GRK3 BTK MAPK9 MAPK10 EPHA7 EPHA8

3.37e-0454218515IPR011009
DomainFH2

FHOD3 FMNL2 DIAPH3

3.99e-04151853PS51444
DomainFH2_Formin

FHOD3 FMNL2 DIAPH3

3.99e-04151853IPR015425
DomainFH2

FHOD3 FMNL2 DIAPH3

3.99e-04151853PF02181
DomainFH2

FHOD3 FMNL2 DIAPH3

3.99e-04151853SM00498
DomainPROTEIN_KINASE_TYR

DDR1 OBSCN YES1 BTK EPHA7 EPHA8

4.08e-04971856PS00109
DomainTyr_kinase_AS

DDR1 OBSCN YES1 BTK EPHA7 EPHA8

4.08e-04971856IPR008266
DomainG8_domain

PKHD1L1 CEMIP

5.78e-0441852IPR019316
DomainG8

PKHD1L1 CEMIP

5.78e-0441852PS51484
DomainG8

PKHD1L1 CEMIP

5.78e-0441852SM01225
DomainG8

PKHD1L1 CEMIP

5.78e-0441852PF10162
DomainPROTEIN_KINASE_ATP

DDR1 GRK5 OBSCN YES1 MKNK1 LIMK1 GRK2 GRK3 BTK MAPK9 MAPK10 EPHA7 EPHA8

6.79e-0445918513PS00107
Domainaa-tRNA-synth_I_CS

WARS1 IARS1 LARS1

6.99e-04181853IPR001412
DomainAA_TRNA_LIGASE_I

WARS1 IARS1 LARS1

8.24e-04191853PS00178
DomainDDT

BAZ1B BAZ1A

9.57e-0451852SM00571
DomainDDT_dom

BAZ1B BAZ1A

9.57e-0451852IPR018501
DomainWHIM1_dom

BAZ1B BAZ1A

9.57e-0451852IPR028942
DomainWHIM2_dom

BAZ1B BAZ1A

9.57e-0451852IPR028941
DomainWSD

BAZ1B BAZ1A

9.57e-0451852PF15613
DomainWHIM1

BAZ1B BAZ1A

9.57e-0451852PF15612
DomainMAPK_JNK

MAPK9 MAPK10

9.57e-0451852IPR008351
DomainProt_kinase_dom

DDR1 GRK5 OBSCN YES1 MKNK1 LIMK1 GRK2 GRK3 BTK MAPK9 MAPK10 EPHA7 EPHA8

1.21e-0348918513IPR000719
DomainSH3_1

ARHGAP42 NPHP1 YES1 DST BTK ARHGEF6 TP53BP2

1.26e-031641857PF00018
DomainPROTEIN_KINASE_DOM

DDR1 GRK5 OBSCN YES1 MKNK1 LIMK1 GRK2 GRK3 BTK MAPK9 MAPK10 EPHA7 EPHA8

1.30e-0349318513PS50011
DomainVWFA

VWA3A ITGAL ITGB3 MDN1 CLCA2

1.33e-03821855PS50234
DomainDDT

BAZ1B BAZ1A

1.43e-0361852PS50827
DomainVal/Leu/Ile-tRNA-synth_edit

IARS1 LARS1

1.43e-0361852IPR009008
DomainAnticodon_1

IARS1 LARS1

1.43e-0361852PF08264
DomainM/V/L/I-tRNA-synth_anticd-bd

IARS1 LARS1

1.43e-0361852IPR013155
Domain-

IARS1 LARS1

1.43e-03618523.90.740.10
DomainSH3

ARHGAP42 NPHP1 OBSCN YES1 DST BTK ARHGEF6 TP53BP2

1.43e-032161858PS50002
DomainACTININ_2

FLNB SYNE1 DST

1.46e-03231853PS00020
DomainACTININ_1

FLNB SYNE1 DST

1.46e-03231853PS00019
DomainActinin_actin-bd_CS

FLNB SYNE1 DST

1.46e-03231853IPR001589
DomainVWA

VWA3A ITGAL ITGB3 MDN1 CLCA2

1.48e-03841855SM00327
DomainSH3_domain

ARHGAP42 NPHP1 OBSCN YES1 DST BTK ARHGEF6 TP53BP2

1.61e-032201858IPR001452
DomainPkinase_Tyr

DDR1 YES1 LIMK1 BTK EPHA7 EPHA8

1.81e-031291856PF07714
DomainTyr_kinase_cat_dom

DDR1 YES1 BTK EPHA7 EPHA8

1.82e-03881855IPR020635
DomainTyrKc

DDR1 YES1 BTK EPHA7 EPHA8

1.82e-03881855SM00219
DomainPH

ARHGAP42 RASGRF2 DOCK9 OBSCN PLEKHM1 GRK2 GRK3 BTK ARHGEF6

1.86e-032781859SM00233
DomainPH_DOMAIN

ARHGAP42 RASGRF2 DOCK9 OBSCN PLEKHM1 GRK2 GRK3 BTK ARHGEF6

1.90e-032791859PS50003
DomainPH_domain

ARHGAP42 RASGRF2 DOCK9 OBSCN PLEKHM1 GRK2 GRK3 BTK ARHGEF6

1.95e-032801859IPR001849
Domainaa-tRNA-synth_Ia

IARS1 LARS1

1.98e-0371852IPR002300
DomaintRNA-synt_1

IARS1 LARS1

1.98e-0371852PF00133
DomainAP_complex_ssu

AP1S3 AP1S1

1.98e-0371852IPR016635
PathwayKEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_TNF_JNK_SIGNALING_PATHWAY

JUN MAPK9 MAPK10

1.07e-0551463M49005
PathwayKEGG_MEDICUS_PATHOGEN_HIV_VPR_TAT_TO_TNF_JNK_SIGNALING_PATHWAY

JUN MAPK9 MAPK10

1.07e-0551463M47570
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_TNF_JNK_SIGNALING_PATHWAY

MAPK9 MAPK10 HTT

2.13e-0561463M47680
PathwayKEGG_MEDICUS_REFERENCE_IL1_IL1R_JNK_SIGNALING_PATHWAY

JUN MAPK9 MAPK10 IL1RAP

3.79e-05191464M47471
PathwayKEGG_MEDICUS_ENV_FACTOR_METALS_TO_JNK_SIGNALING_PATHWAY

JUN MAPK9 MAPK10

5.87e-0581463M47814
PathwayPID_CDC42_PATHWAY

YES1 JUN LIMK1 DIAPH3 MAPK9 ARHGEF6

8.46e-05701466M81
PathwayREACTOME_ACTIVATION_OF_THE_AP_1_FAMILY_OF_TRANSCRIPTION_FACTORS

JUN MAPK9 MAPK10

1.24e-04101463MM15135
PathwayREACTOME_ACTIVATION_OF_THE_AP_1_FAMILY_OF_TRANSCRIPTION_FACTORS

JUN MAPK9 MAPK10

1.24e-04101463M13962
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

FLNB WARS1 CASP14 TBPL1 IARS1 DHX40 BAG2 LARS1 BAZ1B RBM28 PGD GRSF1 PAICS HNRNPH1 HNRNPH3 RHOG DST MDN1 BAZ1A SERPINB12 A2ML1 PYGB EBNA1BP2 TOP2B TP53BP2

1.11e-0713531902529467282
Pubmed

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.

MKNK1 JUN MAPK9 TOP2B

5.94e-071319049155018
Pubmed

A selective small-molecule inhibitor of c-Jun N-terminal kinase 1.

JUN MAPK9 MAPK10

6.39e-074190319527717
Pubmed

DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury.

JUN MAPK9 MAPK10

6.39e-074190324878510
Pubmed

JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death.

JUN MAPK9 MAPK10

6.39e-074190322353563
Pubmed

c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation.

JUN MAPK9 MAPK10

6.39e-074190315528206
Pubmed

Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.

GRK5 GRK2 GRK3

6.39e-07419038917529
Pubmed

c-JUN N-terminal kinase-1 (JNK1) but not JNK2 or JNK3 is involved in UV signal transduction in human epidermis.

JUN MAPK9 MAPK10

6.39e-074190316824735
Pubmed

Neuronal c-Jun is required for successful axonal regeneration, but the effects of phosphorylation of its N-terminus are moderate.

JUN MAPK9 MAPK10

6.39e-074190322372722
Pubmed

Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder.

GRK5 GRK2 GRK3

6.39e-074190321784156
Pubmed

Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C.

GRK5 GRK2 GRK3

6.39e-07419038662816
Pubmed

Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice.

PPARG APOE GRK2

1.59e-065190326670611
Pubmed

The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.

JUN MAPK9 MAPK10

1.59e-065190310230788
Pubmed

Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine.

GRK5 GRK2 GRK3

1.59e-065190310338466
Pubmed

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

WWC3 SYNE1 RALGAPA2 CEMIP RIMKLB MTUS1 TLE4

1.65e-06103190710574462
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

GPD2 FLNB WARS1 IARS1 SYNE1 LARS1 TMED7 OGDH PGD PAICS HNRNPH1 DST MDN1 PACS2 PYGB HYDIN MYO16

2.44e-068071901730575818
Pubmed

Neuroprotection by histone deacetylase-related protein.

JUN MAPK9 MAPK10

3.17e-066190316611996
Pubmed

Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions.

GRK5 GRK2 GRK3

3.17e-066190336451830
Pubmed

beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.

GRK5 GRK2 GRK3

3.17e-06619039826657
Pubmed

A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria.

JUN MAPK9 MAPK10

3.17e-066190312167088
Pubmed

Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.

GRK5 GRK2 GRK3

5.53e-067190311517230
Pubmed

Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.

GRK5 GRK2 GRK3

5.53e-06719038672451
Pubmed

Selective interaction of JNK protein kinase isoforms with transcription factors.

JUN MAPK9 MAPK10

8.81e-06819038654373
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

GPD2 FLNB WARS1 ATR IARS1 SYNE1 SPTLC1 LARS1 BAZ1B OGDH PGD GRSF1 PAICS HNRNPH1 HNRNPH3 MDN1 CLCA2 BAZ1A SERPINB12 SGO2 EBNA1BP2 TOP2B

1.21e-0514251902230948266
Pubmed

Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase.

JUN MAPK9 MAPK10

1.32e-05919039596579
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

GPD2 FLNB CASP14 IARS1 SYNE1 BAG2 LARS1 BAZ1B RBM28 YES1 HNRNPH1 HNRNPH3 DST MDN1 BAZ1A SERPINB12 EBNA1BP2 TOP2B

1.46e-0510241901824711643
Pubmed

JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure.

JUN MAPK9 MAPK10

1.87e-0510190312756228
Pubmed

Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice.

JUN MAPK9 MAPK10

1.87e-0510190317984095
Pubmed

A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates.

JUN MAPK9 MAPK10

1.87e-0510190312788955
Pubmed

The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis.

JUN MAPK9 MAPK10

1.87e-0510190315375216
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

PNMA1 LARS1 BAZ1B RBM28 OGDH GRSF1 HNRNPH1 HNRNPH3 MDN1 BAZ1A SGO2 EBNA1BP2 HSPA14 TOP2B HERC5

2.05e-057591901535915203
Pubmed

Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.

FLNB WARS1 OGDH PGD IFIT3 NFIX HERC5

2.16e-05152190716009940
Pubmed

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

FLNB IARS1 OGDH ITGB3 HNRNPH1 JUN MDN1 GRK2 BTK HTT

2.17e-053441901030333137
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

FLNB PDE2A WARS1 SYNE1 SIPA1L3 LARS1 DDIT4L APOE FMNL2 PAICS ME3 RHOG LIMK1 FRY NPRL2 DST COMMD1 ASB3 PNMA2 AFF4

2.75e-0512851902035914814
Pubmed

Irbesartan increased PPARγ activity in vivo in white adipose tissue of atherosclerotic mice and improved adipose tissue dysfunction.

PPARG APOE

2.97e-052190221296052
Pubmed

A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure.

GRK5 GRK2

2.97e-052190218425130
Pubmed

Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2.

GRK5 APOE

2.97e-052190217018529
Pubmed

Dysfunction of G protein-coupled receptor kinases in Alzheimer's disease.

GRK5 GRK2

2.97e-052190220730384
Pubmed

Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA/2J mice.

MAPK9 MAPK10

2.97e-052190229899326
Pubmed

Gene- Gene Interaction between PPARG and APOE Gene on Late-Onset Alzheimer's Disease: A Case- Control Study in Chinese Han Population.

PPARG APOE

2.97e-052190228346566
Pubmed

Polymorphisms in genes coding for GRK2 and GRK5 and response differences in antihypertensive-treated patients.

GRK5 GRK2

2.97e-052190221127457
Pubmed

Interleukin-1 receptor accessory protein blockade limits the development of atherosclerosis and reduces plaque inflammation.

APOE IL1RAP

2.97e-052190238563353
Pubmed

CD4-dependent generation of dominant transplantation tolerance induced by simultaneous perturbation of CD154 and LFA-1 pathways.

ITGAL CD40LG

2.97e-052190212391193
Pubmed

Autophosphorylation properties of inactive and active JNK2.

JUN MAPK9

2.97e-052190217637567
Pubmed

KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS.

MAPK9 MAPK10

2.97e-052190228871032
Pubmed

Antiatherogenic effect of pioglitazone on uremic apolipoprotein E knockout mice by modulation of the balance of regulatory and effector T cells.

PPARG APOE

2.97e-052190221868013
Pubmed

Cloning of GRK2 cDNA from S49 murine lymphoma cells.

GRK2 GRK3

2.97e-05219028638670
Pubmed

Genetic variation and cognitive dysfunction one year after cardiac surgery.

APOE ITGB3

2.97e-052190223384292
Pubmed

Pro- and antiatherogenic effects of a dominant-negative P465L mutation of peroxisome proliferator-activated receptor-γ in apolipoprotein E-Null mice.

PPARG APOE

2.97e-052190222539598
Pubmed

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.

GRK2 GRK3

2.97e-052190233060647
Pubmed

Rosiglitazone treatment prevents mitochondrial dysfunction in mutant huntingtin-expressing cells: possible role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in the pathogenesis of Huntington disease.

PPARG HTT

2.97e-052190218640979
Pubmed

Pallidal neuronal apolipoprotein E in pantothenate kinase-associated neurodegeneration recapitulates ischemic injury to the globus pallidus.

APOE PANK2

2.97e-052190226547561
Pubmed

Interactions between c-Jun, nuclear factor 1, and JC virus promoter sequences: implications for viral tropism.

JUN NFIX

2.97e-052190216928756
Pubmed

Clearing Amyloid-β through PPARγ/ApoE Activation by Genistein is a Treatment of Experimental Alzheimer's Disease.

PPARG APOE

2.97e-052190226890773
Pubmed

Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity.

JUN BTK

2.97e-05219029108083
Pubmed

Pro12Ala sequence variant of the PPARG gene is associated with postprandial hypertriglyceridemia in non-E3/E3 patients with the metabolic syndrome.

PPARG APOE

2.97e-052190216916989
Pubmed

Identification of four splice variants of the mouse stress-activated protein kinase JNK/SAPK alpha-isoform.

MAPK9 MAPK10

2.97e-05219028817558
Pubmed

alpha Pix enhances mutant huntingtin aggregation.

ARHGEF6 HTT

2.97e-052190219969308
Pubmed

Serine palmitoyltransferase (SPT) deficient mice absorb less cholesterol.

SPTLC1 APOE

2.97e-052190219416652
Pubmed

G protein-coupled receptor kinase 2 expression and activity are associated with blood pressure in black Americans.

GRK5 GRK2

2.97e-052190219487588
Pubmed

X Chromosome-wide Association Study Identifies a Susceptibility Locus for Inflammatory Bowel Disease in Koreans.

CD40LG ARHGEF6

2.97e-052190228333213
Pubmed

Requirement for CD154 in the progression of atherosclerosis.

APOE CD40LG

2.97e-052190210546000
Pubmed

JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration.

MAPK9 MAPK10

2.97e-052190219014392
Pubmed

PPARγ Pro12Ala and His447His polymorphisms and susceptibility to Alzheimer's disease: a meta-analysis.

PPARG APOE

2.97e-052190226125935
Pubmed

Anti-oxLDL antibody isotype levels, as potential markers for progressive atherosclerosis in APOE and APOECD40L mice.

APOE CD40LG

2.97e-052190218778362
Pubmed

Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.

GRK2 GRK3

2.97e-052190210198406
Pubmed

G-protein coupled receptor kinase 2 and 3 expression in human detrusor cultured smooth muscle cells.

GRK2 GRK3

2.97e-052190211762794
Pubmed

Myocardial G protein receptor-coupled kinase expression correlates with functional parameters and clinical severity in advanced heart failure.

GRK5 GRK2

2.97e-052190222196842
Pubmed

Impaired neutrophil chemotaxis in sepsis associates with GRK expression and inhibition of actin assembly and tyrosine phosphorylation.

GRK5 GRK2

2.97e-052190216849637
Pubmed

Lipocalin prostaglandin D synthase and PPARγ2 coordinate to regulate carbohydrate and lipid metabolism in vivo.

PPARG PTGDS

2.97e-052190222792179
Pubmed

Knockout of the l-pgds gene aggravates obesity and atherosclerosis in mice.

APOE PTGDS

2.97e-052190219070593
Pubmed

CD40 ligand promotes Mac-1 expression, leukocyte recruitment, and neointima formation after vascular injury.

APOE CD40LG

2.97e-052190218349125
Pubmed

Constitutive activity of JNK2 alpha2 is dependent on a unique mechanism of MAPK activation.

JUN MAPK9

2.97e-052190218940813
Pubmed

G protein--coupled receptor kinases.

GRK2 GRK3

2.97e-05219028035170
Pubmed

Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders.

PNMA1 PNMA2

2.97e-052190210050892
Pubmed

Gene-gene interaction of PPARgamma and ApoE affects coronary heart disease risk.

PPARG APOE

2.97e-052190214659862
Pubmed

Nifedipine induces peroxisome proliferator-activated receptor-gamma activation in macrophages and suppresses the progression of atherosclerosis in apolipoprotein E-deficient mice.

PPARG APOE

2.97e-052190220508203
Pubmed

Identification of a specific domain responsible for JNK2alpha2 autophosphorylation.

JUN MAPK9

2.97e-052190215637069
Pubmed

Digenic inheritance of severe insulin resistance in a human pedigree.

PPARG PPP1R3A

2.97e-052190212118251
Pubmed

The E3 ligase HERC5 promotes antimycobacterial responses in macrophages by ISGylating the phosphatase PTEN.

HERC6 HERC5

2.97e-052190237279284
Pubmed

G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors.

GRK5 APOE

2.97e-052190222095977
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

FLNB WARS1 IARS1 SPTLC1 LARS1 TMED7 YES1 PGD GRSF1 PAICS HNRNPH3 RHOG MTMR4 DST TMTC3 BAZ1A RAD1 DIAPH3 EBNA1BP2 PLOD2

3.14e-0512971902033545068
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

WARS1 TBPL1 IARS1 BAG2 SPTLC1 LARS1 BAZ1B RBM28 GRSF1 PAICS HNRNPH1 HNRNPH3 RHOG AP1S1 MDN1 BTK SAP30BP BRD9 EBNA1BP2 TOP2B

3.93e-0513181902030463901
Pubmed

The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer.

IARS1 LARS1 RBM28 JUN PANK2

4.49e-0571190529346117
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

FLNB DHX40 SYNE1 OGDH DST MDN1 UTY TOP2B

4.73e-05234190836243803
Pubmed

p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance.

WARS1 IARS1 LARS1

5.59e-0514190312060739
Pubmed

Expression of multiple formins in adult tissues and during developmental stages of mouse brain.

FHOD3 FMNL2 DIAPH3

5.59e-0514190326272686
Pubmed

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.

CASP14 IARS1 LARS1 BAZ1B SRP19 RBM28 PGD PAICS HNRNPH1 HNRNPH3 SERPINB12 EBNA1BP2 TOP2B

5.69e-056411901336057605
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

WARS1 CASP14 DHX40 PGD HNRNPH1 HNRNPH3 JUN DST BAZ1A SERPINB12 TP53BP2

6.32e-054721901138943005
Pubmed

Vti1b promotes TRPV1 sensitization during inflammatory pain.

FLNB IARS1 DOCK9 OGDH HNRNPH1 DST

7.34e-05127190630335684
Pubmed

Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome.

PPARG APOE PPP1R3A LIMK1 CD40LG

7.50e-0579190519056482
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

MTERF1 IARS1 LARS1 PPARG JUN MDN1 BAZ1A NFIX TLE4 A2ML1 MAPK9 PLOD2 HSPA14 TOP2B HERC5

8.09e-058571901525609649
Pubmed

JNK Isoforms Are Involved in the Control of Adult Hippocampal Neurogenesis in Mice, Both in Physiological Conditions and in an Experimental Model of Temporal Lobe Epilepsy.

MAPK9 MAPK10

8.87e-053190230685843
Pubmed

Phosphorylation of c-jun mediated by MAP kinases.

JUN MAPK10

8.87e-05319021922387
Pubmed

Genes, fat intake, and cardiovascular disease risk factors in the Quebec Family Study.

PPARG APOE

8.87e-053190217890503
Pubmed

Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis.

APOE CD40LG

8.87e-053190220705757
Pubmed

Interaction between PPARG Pro12Ala and ADIPOQ G276T concerning cholesterol levels in childhood obesity.

PPARG APOE

8.87e-053190218645733
Pubmed

Pleckstrin homology domain of G protein-coupled receptor kinase-2 binds to PKC and affects the activity of PKC kinase.

GRK2 BTK

8.87e-053190212679936
Pubmed

JNK2 is a positive regulator of the cJun transcription factor.

JUN MAPK9

8.87e-053190216973441
Pubmed

The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases.

MAPK9 MAPK10

8.87e-053190234502556
Cytoband4q22.1

TIGD2 HERC6 HERC5

1.69e-042619034q22.1
CytobandEnsembl 112 genes in cytogenetic band chr4q22

MMRN1 TIGD2 HERC6 HERC5

2.61e-04741904chr4q22
GeneFamilyAminoacyl tRNA synthetases, Class I

WARS1 IARS1 LARS1

3.31e-04191313131
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

RASGRF2 DOCK9 PLEKHM1 GRK2 GRK3 BTK ARHGEF6

7.63e-042061317682
CoexpressionBAELDE_DIABETIC_NEPHROPATHY_DN

WARS1 IARS1 GRK5 PTGDS ITGB3 TGFBR3 FRY DST LRIG1 TLE4 PNMA2 FGF9 PLOD2 TOP2B

3.84e-0643718914M4665
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

FLNB SLC11A2 ATR DOCK9 GRK5 BAZ1B HNRNPH3 CEMIP PIKFYVE TGFBR3 USP6 JUN DST MDN1 LRIG1 BAZ1A TLE4 IL1RAP PLOD2 TP53BP2

4.17e-0685618920M4500
CoexpressionGSE13485_DAY3_VS_DAY21_YF17D_VACCINE_PBMC_UP

FNIP2 SLC11A2 WARS1 FMNL2 IFIT3 MKNK1 ZNF746 HERC6 HERC5

1.18e-051931899M3303
CoexpressionGSE42088_UNINF_VS_LEISHMANIA_INF_DC_8H_DN

ZNF93 MAGEC3 FHOD3 TRIL USP6 SLC9A3 DST MTUS1 MAPK9

1.39e-051971899M9910
CoexpressionGSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_NFKBP50_KO_MACROPHAGE_DN

CYB5RL AP1S3 RTEL1 IPP ITGB3 NFIX CD40LG HERC6 ARHGEF6

1.51e-051991899M8113
CoexpressionGSE37301_MULTIPOTENT_PROGENITOR_VS_GRAN_MONO_PROGENITOR_DN

GPD2 DDR1 WARS1 LARS1 SRP19 ITGB3 IFIT3 JUN RAD1

1.57e-052001899M8849
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated|COVID-19_Mild / Disease, condition lineage and cell class

RASGRF2 DOCK9 OBSCN IFIT3 THEM4 DST MDN1 CD40LG HERC6 HERC5

1.52e-0820018910d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCellCOVID-19-Endothelial_cells-Systemic_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

FLNB PDE2A RASGRF2 DOCK9 RALGAPA2 SLC5A4 MMRN1 TGFBR3 SLCO2A1

1.02e-071851899f5e14181f45c37d13ee9e017a4c8bc248c353676
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AP1S3 SYNE1 SIPA1L3 XKR4 ZNF462 KLHL13 DIAPH3 HYDIN EPHA7

1.17e-07188189963a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCellEndothelial-A-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

PDE2A RASGRF2 DOCK9 GRK5 PTGDS MMRN1 TGFBR3 SLCO2A1 HAPLN3

1.34e-071911899f702dfe88a9b04091dae87df61b2b4f43525f86a
ToppCellLA-09._Endothelium_I|World / Chamber and Cluster_Paper

FLNB WARS1 RASGRF2 SYNE1 DOCK9 RALGAPA2 MMRN1 SLC9C1 SLCO2A1

1.60e-071951899fc95457a298b5d0dab687d9ee7e225a7f7b9a0d4
ToppCellLA-09._Endothelium_I|LA / Chamber and Cluster_Paper

FLNB WARS1 RASGRF2 SYNE1 DOCK9 RALGAPA2 MMRN1 SLC9C1 SLCO2A1

1.75e-071971899ab6d1ab586a188597a39854ef980b8955ebcc645
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ARHGAP42 SYNE1 TGFBR3 DST MTUS1 NFIX KLHL13 CPLANE1 EPHA7

1.99e-072001899dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCellBronchial_Biopsy-Endothelial-Lymphatic|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

ATP8B3 PDE2A CYB5RL PPARG PKHD1L1 MMRN1 TRIL HERC5

7.48e-071721898c41f5a66781bbf63afce7ca5d118cc6d8e0fe0bc
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tnaive/CM_CD4|GI_large-bowel / Manually curated celltypes from each tissue

CYB5RL OBSCN RBM28 IFIT3 THEM4 TIGD2 TLE4 HERC6

9.29e-071771898eb87ea93e36a8f97442ec8515f658ee61932dc0f
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

REP15 PNLIP MTERF1 PKHD1L1 ITGB3 MMRN1 CLCA2 UTY

1.19e-061831898919c9861073d12fd12aecd7469b1478b13838c43
ToppCell5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA6B PDE2A CYB5RL RALGAPA2 MMRN1 FRY SLCO2A1 HAPLN3

1.35e-061861898055cc23c4db9aad2d6c62e62c8e58bfe5047c6b1
ToppCellLV-10._Endothelium_II|World / Chamber and Cluster_Paper

FLNB RASGRF2 DOCK9 RALGAPA2 PKHD1L1 INO80D MMRN1 SLCO2A1

1.40e-0618718987876dcb4800c2e54874df3d933efb79307a64a97
ToppCellCOVID-19-lung-Vein_EC|lung / Disease (COVID-19 only), tissue and cell type

FLNB RASGRF2 DOCK9 RALGAPA2 PKHD1L1 MMRN1 TGFBR3 SLCO2A1

1.46e-061881898d582b76fc2faac526c9bf97503041129e1a6a211
ToppCellCOPD-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

SYNE1 GRK5 YES1 HNRNPH1 TGFBR3 LRIG1 DIAPH3 HYDIN

1.46e-061881898186fe1ea328c942910190a4240262c0d8642ea3b
ToppCellRA-10._Endothelium_II|RA / Chamber and Cluster_Paper

FLNB RASGRF2 DOCK9 GRK5 RALGAPA2 PKHD1L1 MMRN1 SLCO2A1

1.52e-061891898c81787a8c662db5d7814c583dd64562857629e81
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AP1S3 EFCAB13 XKR4 ZNF462 LGI2 DIAPH3 HYDIN EPHA7

1.64e-061911898d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellRA-09._Endothelium_I|World / Chamber and Cluster_Paper

FLNB WARS1 RASGRF2 SYNE1 DOCK9 RALGAPA2 PKHD1L1 SLCO2A1

1.64e-061911898c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCellRA-09._Endothelium_I|RA / Chamber and Cluster_Paper

FLNB WARS1 RASGRF2 SYNE1 DOCK9 RALGAPA2 PKHD1L1 SLCO2A1

1.71e-0619218988a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

AP1S3 EFCAB13 XKR4 JUN RIMKLB SLCO2A1 SERPINB11 KLHL13

1.78e-061931898ca7c0a4ceb05bced90f6cdc53d278e547fb241e9
ToppCellRV-10._Endothelium_II|World / Chamber and Cluster_Paper

FLNB RASGRF2 DOCK9 GRK5 RALGAPA2 PKHD1L1 MMRN1 SLCO2A1

1.78e-0619318982531266bc57339d4e2b22a88817008e32b8c1598
ToppCellRV-10._Endothelium_II|RV / Chamber and Cluster_Paper

FLNB RASGRF2 DOCK9 GRK5 RALGAPA2 PKHD1L1 MMRN1 SLCO2A1

1.78e-06193189801c2df9206f1527c578e808978e58196c35e72f5
ToppCellLV-10._Endothelium_II|LV / Chamber and Cluster_Paper

FLNB RASGRF2 DOCK9 RALGAPA2 PKHD1L1 INO80D MMRN1 SLCO2A1

1.85e-061941898b6cc849fa08599bff9839ef382d190cc964e273e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B FLNB WARS1 RASGRF2 DOCK9 RALGAPA2 YES1 SLCO2A1

1.92e-061951898818bc18c5834238e5f733cac6fe928ed0788f57d
ToppCellbackground-Endothelial_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

PDE2A WARS1 DOCK9 FMNL2 MMRN1 ZNF462 TGFBR3 RIMKLB

1.99e-061961898e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NPHP1 VWA3A SYNE1 CFAP74 CPLANE1 MAPK10 FLACC1 HYDIN

2.07e-06197189874a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellTracheal-NucSeq-Endothelial-Endothelia_vascular-VE_capillary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA6B REP15 RASGRF2 SYNE1 SLC5A4 LGI2 SLCO2A1 HAPLN3

2.07e-06197189831bec97c3952c48031bd66a5dad16a70a61519c3
ToppCell5'-Adult-Appendix-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDE2A WARS1 DOCK9 RALGAPA2 PKHD1L1 MMRN1 MTUS1 SLCO2A1

2.15e-06198189890e85fe7a0ab376a41666dfff6c0e95b7f1c9475
ToppCellCOVID-19-lung-Capillary_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

WARS1 DOCK9 GRK5 RALGAPA2 INO80D SLC5A4 SLCO2A1 CDC25B

2.15e-06198189845419f2804b4be79bae6632e71c54e1af482d115
ToppCell367C-Endothelial_cells|367C / Donor, Lineage, Cell class and subclass (all cells)

FLNB PDE2A DOCK9 RALGAPA2 MMRN1 FRY MTUS1 SLCO2A1

2.23e-061991898636ff80938907f137e955388797072ab45289062
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ARHGAP42 SYNE1 TGFBR3 DST MTUS1 NFIX KLHL13 EPHA7

2.23e-061991898e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_venous|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA6B PDE2A DOCK9 RALGAPA2 MMRN1 MTUS1 SLCO2A1 HAPLN3

2.23e-0619918986fb81388c5045e81c3849a7136bdff3f953f044e
ToppCell367C-Endothelial_cells-Endothelial-A_(Artery)-|367C / Donor, Lineage, Cell class and subclass (all cells)

FLNB PDE2A DOCK9 RALGAPA2 MMRN1 FRY MTUS1 SLCO2A1

2.23e-061991898c2d85f80037f209a4a329790f475d9f98f590262
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-CD4_INF-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IFIT3 CCNH JUN BAZ1A CD40LG HAPLN3 HERC6 HERC5

2.23e-061991898d3f36ede2fade550ec8f21a0448e71e1ff579ee2
ToppCell367C-Endothelial_cells-Endothelial-A_(Artery)|367C / Donor, Lineage, Cell class and subclass (all cells)

FLNB PDE2A DOCK9 RALGAPA2 MMRN1 FRY MTUS1 SLCO2A1

2.23e-06199189829ed081bd5204a32068b420f2244f3704891547b
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_venous|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA6B DOCK9 RALGAPA2 PTGDS PKHD1L1 MMRN1 SLCO2A1 HAPLN3

2.32e-062001898cb00760ae75c30b1cb8526534aabd4ffc7c21000
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Bronchial_vessel|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

FLNB PDE2A DOCK9 RALGAPA2 MMRN1 TGFBR3 SLCO2A1 HAPLN3

2.32e-06200189871979bbcc035d5b8882f1502b5a8ef248aaba45a
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Bronchial_vessel-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FLNB PDE2A DOCK9 RALGAPA2 MMRN1 TGFBR3 SLCO2A1 HAPLN3

2.32e-062001898c55efd997392e99068b673542f56f1a209c5a6c8
ToppCellParenchyma_COVID-19-Endothelial-TX-Bronchial_vessel|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

FLNB PDE2A DOCK9 RALGAPA2 MMRN1 TGFBR3 SLCO2A1 HAPLN3

2.32e-062001898a18817d36b2b30a32e1513d36174bf98dfea2a92
ToppCellBronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_venous|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA6B PDE2A DOCK9 RALGAPA2 MMRN1 MTUS1 SLCO2A1 HAPLN3

2.32e-062001898a3b09580738783c6bff31ea33d5188912e56b8a7
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1-41|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

REP15 CSMD3 ZNF462 MTUS1 EHHADH HAPLN3 EPHA7

5.16e-0615818976d2709b387945c015faa223c20d22b52a4082140
ToppCelldroplet-Lung-nan-3m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AP1S3 MDN1 GRK3 SERPINB12 NXF2 CLEC10A ARHGEF6

6.59e-061641897a67dd181eba275c191f4d0cab13df30eaa3ad913
ToppCellLPS-antiTNF-Epithelial_airway-Mes-Epi-like|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THNSL1 HNRNPH1 THEM4 CD22 SGO2 DMRTA1 DIAPH3

6.59e-0616418974307b002fb41ddfc7ab8a6bca66a60942c250052
ToppCellLPS-antiTNF-Epithelial_airway-Mes-Epi-like-Airway|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THNSL1 HNRNPH1 THEM4 CD22 SGO2 DMRTA1 DIAPH3

6.59e-0616418971d84aa5b925f502ee9c5fa39714490f613a58028
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SEMA6B FLNB WARS1 DOCK9 RALGAPA2 MMRN1 SLCO2A1

7.13e-061661897f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PDE2A SYNE1 DOCK9 PKHD1L1 KCNU1 SLCO2A1 HERC6

8.02e-061691897987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NPHP1 VWA3A CFAP74 CPLANE1 MAPK10 FLACC1 HYDIN

8.02e-061691897fba841664939c771881ba97f14ef1df6635c04ff
ToppCelldroplet-Spleen-nan-18m-Myeloid-macrophage_dendritic_cell_progenitor|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDR1 OBSCN PTGDS FMNL2 DST CLEC10A PLOD2

8.66e-0617118974e856441063e9825b6f87a1d3dd19c77dae4662c
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 PPARG APOE ITGAL FMNL2 TGFBR3 GRK3

1.01e-051751897cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCellCOVID-19_Severe-CD4+_CTL|COVID-19_Severe / disease group, cell group and cell class

SYNE1 DDIT4L XKR4 CEMIP CCNH TGFBR3 CD40LG

1.08e-05177189734e9455790bae905dd91923792f4109d18b7686e
ToppCell5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

WARS1 SYNE1 DOCK9 RALGAPA2 PKHD1L1 ITGB3 MMRN1

1.30e-051821897fd786c88826ad3d5cc5c3d80f8e392d6be1b5267
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STXBP5L OBSCN CSMD3 PKHD1L1 HYDIN MYO16 EPHA7

1.39e-0518418972cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STXBP5L OBSCN CSMD3 PKHD1L1 HYDIN MYO16 EPHA7

1.39e-0518418972b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell5'-Adult-Appendix-Endothelial-lymphatic_endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

WARS1 SYNE1 DOCK9 RALGAPA2 PKHD1L1 ITGB3 MMRN1

1.39e-051841897453295362888c9a59d0e73c7a5b15914c50ff591
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STXBP5L OBSCN CSMD3 PKHD1L1 HYDIN MYO16 EPHA7

1.39e-051841897ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCelldroplet-Heart-nan-18m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA6B PDE2A DOCK9 PPARG FRY PHOSPHO1 ELOVL3

1.44e-051851897a32d5cb596ebac80eb1ac301055e65d420879ec8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

VWA3A SYNE1 EFCAB13 XKR4 FRY TLE4 IL1RAP

1.44e-0518518978816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

VWA3A SYNE1 EFCAB13 XKR4 FRY TLE4 IL1RAP

1.44e-05185189734fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DDIT4L XKR4 ZNF462 LGI2 DIAPH3 HYDIN EPHA7

1.49e-0518618975c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCellMyeloid-B_(Activated_Macrophage)|World / shred on cell class and cell subclass (v4)

FNIP2 PPARG ITGAL PGD DST BAZ1A BTK

1.49e-05186189733d731a7883d75e4e7db83b641cdb1e9a39938bf
ToppCellcritical-Myeloid-Monocyte-derived_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

WARS1 APOE FMNL2 IFIT3 HAPLN3 HERC6 HERC5

1.55e-05187189772e4aec49ea0c5fe6cee2a1a46369dbc90cd3fad
ToppCelldroplet-Heart-nan-18m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA3A SEMA6B PDE2A PPARG FRY PHOSPHO1 ELOVL3

1.60e-0518818979dfa2e0b73640459cdf88277291e3ab9c33e0217
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DDIT4L XKR4 ZNF462 LGI2 DIAPH3 HYDIN EPHA7

1.66e-051891897904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCellRA-10._Endothelium_II|World / Chamber and Cluster_Paper

FLNB DOCK9 GRK5 RALGAPA2 PKHD1L1 MMRN1 SLCO2A1

1.66e-05189189775c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDE2A DOCK9 RALGAPA2 PKHD1L1 MMRN1 UBR3 HAPLN3

1.71e-05190189732400c62cb9de4c2b24af4206c21a0215ab12212
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDE2A WARS1 DOCK9 RALGAPA2 PKHD1L1 MMRN1 UBR3

1.71e-051901897b2bd2cb384bb8a5662064ed1aee68e905e1f780d
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

WWC3 SYNE1 DOCK9 GRK5 OBSCN TGFBR3 SLCO2A1

1.71e-0519018970a351609a72fd638c84b2435782e312ee6a33aac
ToppCellfacs-Lung-3m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEMA6B PDE2A YES1 PKHD1L1 ME3 MMRN1 CLCA2

1.71e-05190189726e2237f65cb43723c5da853831b40df2982d6e4
ToppCellCOVID-19-lung-Vein_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

DOCK9 RALGAPA2 PKHD1L1 SLC5A4 MMRN1 TGFBR3 SLCO2A1

1.71e-0519018971caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RASGRF2 RTEL1 DOCK9 SLC5A4 MMRN1 LGI2 SLCO2A1

1.71e-05190189706bfb62b94b0faf467ef93d5bc5d08924c770098
ToppCellfacs-Lung-3m-Endothelial-lymphatic_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEMA6B PDE2A YES1 PKHD1L1 ME3 MMRN1 CLCA2

1.71e-051901897a1514d2186eb4fe569971ab22dc0c17d353fb94a
ToppCellPCW_13-14|World / Celltypes from embryonic and fetal-stage human lung

GRK5 RALGAPA2 DST GRK3 CD22 NFIX UTY

1.71e-05190189762a3ec1ae0829602b0569cc051210551644f1d46
ToppCellfacs-Lung-3m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEMA6B PDE2A YES1 PKHD1L1 ME3 MMRN1 CLCA2

1.71e-0519018970bb954a94317cfc742b9b6221bb80f8baa6d3ff1
ToppCellfacs-Heart-LV-24m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OBSCN FHOD3 PTGDS ME3 PPP1R3A CFAP20DC ASB11

1.77e-0519118979d7d680da3979e256191b534ebd14c5383e0cf93
ToppCellfacs-Heart-LV-24m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OBSCN FHOD3 PTGDS ME3 PPP1R3A CFAP20DC ASB11

1.77e-051911897543da1197c7e62f2c9cbd4a51414bbaaa6d1a92f
ToppCellCOVID-19-kidney-VWF+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

SEMA6B PDE2A RASGRF2 DOCK9 YES1 SLC5A4 SLCO2A1

1.77e-0519118972f00d0b7b2ffce8eb3eb5bbae49a0d425b23c982
ToppCellCOVID-19-Heart-EC_(POSTN)|Heart / Disease (COVID-19 only), tissue and cell type

FLNB DOCK9 RALGAPA2 PKHD1L1 INO80D MMRN1 SLCO2A1

1.83e-051921897c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-T4_em|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

IFIT3 THEM4 CD40LG HAPLN3 HERC6 CDC25B HERC5

1.83e-051921897e07b6892276c81c1227e94ca942f6820d89a7ca3
ToppCellNS-critical-d_07-13-Myeloid-Monocyte-derived_Macrophage|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

WARS1 APOE FMNL2 IFIT3 HAPLN3 CLEC10A HERC5

1.90e-0519318970dd83b21e164147abfd511a927615c40a28781a2
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

VWA3A LRIG1 NFIX CFAP74 CPLANE1 MAPK10 HYDIN

1.90e-051931897ea345d34440b25f65358a53dc72831998d1c3620
ToppCell5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWA3A PDE2A DOCK9 RALGAPA2 PKHD1L1 MMRN1 MTUS1

1.90e-051931897bd0027fa97de41ae22ff64a61c8e217496f122ca
ToppCell5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA6B PDE2A PKHD1L1 MMRN1 MTUS1 SLCO2A1 HAPLN3

1.90e-051931897c0973a2c97deb7176c2f617c8760a55f7edc9839
ToppCellCOVID-19_Moderate-CD4+_T_activated|World / disease group, cell group and cell class

DOCK9 IFIT3 THEM4 CD40LG HAPLN3 HERC6 HERC5

1.90e-051931897c2a2a2c14a7085690262db5c2a70e38db67dee18
ToppCellHippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)|Hippocampus / BrainAtlas - Mouse McCarroll V32

AP1S3 OBSCN ITGAL PKHD1L1 EPHA8

1.92e-05771895a799ccdb84014e978d9fbccf3d2fee8fbeac7b0c
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NPHP1 VWA3A SYNE1 CFAP74 MAPK10 HYDIN CFAP99

1.96e-0519418974a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCellcritical-Myeloid-Monocyte-derived_Macrophage|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

WARS1 APOE FMNL2 IFIT3 HAPLN3 CLEC10A HERC5

1.96e-051941897e36d1fd141bdcbd9ed66a33de6cdfde77189a0c1
ToppCellCOVID-19-Heart-EC_1|Heart / Disease (COVID-19 only), tissue and cell type

WARS1 RASGRF2 SYNE1 DOCK9 PPARG YES1 SLC9C1

2.03e-05195189750a193475db1bb1e05b8590225a553688c372c14
ToppCellCOVID_non-vent-Lymphocytic-T_cell-CD4+_Memory_T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

DOCK9 THEM4 DST LRIG1 CD40LG HERC6 CDC25B

2.03e-05195189722191d361af136942508f1553ff41a626ed982ad
ToppCell390C-Lymphocytic-NK_cells-NK_cell_B2|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

NPHP1 GRK5 PPARG CEMIP SDR9C7 FLACC1

2.05e-05131189696d300958545714d18e905e860e95469c8ae4efa
ToppCell3'-GW_trimst-2-LargeIntestine-Endothelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDE2A DOCK9 PRND CEMIP MMRN1 SLCO2A1 HAPLN3

2.09e-0519618979b53e3fdb23dbdfc2e7ce012c6b2ce50700c95d5
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

ARHGAP42 VWA3A SYNE1 YES1 HNRNPH1 MAPK10 HYDIN

2.09e-0519618976d02d494196e3f857d53eea46d9419690d43beca
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

ARHGAP42 VWA3A SYNE1 YES1 HNRNPH1 MAPK10 HYDIN

2.09e-051961897af4cdc61830685a888a1209826c23bcf54a43084
ToppCellCOVID-19-lung-Capillary_Aerocytes|COVID-19 / Disease (COVID-19 only), tissue and cell type

WARS1 WWC3 SYNE1 DOCK9 RALGAPA2 TGFBR3 SLCO2A1

2.09e-05196189749cc0a2b9739abad61dff7292ea0b14d28ff35c4
ToppCellCOVID-19-kidney-VWF+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

SEMA6B PDE2A RASGRF2 DOCK9 GRK5 SLC5A4 SLCO2A1

2.09e-051961897b71b197cb92117dd9efaa13de000841901cc4ca8
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PTGDS PKHD1L1 MMRN1 SLCO2A1 SGO2 DIAPH3 CDC25B

2.16e-05197189776b61e60a757e58b465569538e632d6d9953e89a
ToppCellLV-09._Endothelium_I|LV / Chamber and Cluster_Paper

WARS1 RASGRF2 SYNE1 DOCK9 MMRN1 SLC9C1 SLCO2A1

2.16e-051971897f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCellTracheal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_venous|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PDE2A PKHD1L1 MMRN1 RIMKLB SLCO2A1 HAPLN3 CBX2

2.16e-051971897a78111171819db746af7b162c77f9a324453f3ce
ToppCellTracheal-NucSeq-Endothelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA6B PDE2A RASGRF2 PKHD1L1 SLC5A4 MMRN1 SLCO2A1

2.24e-05198189777e31b6edeeb5ccd5cd3f080898c96bf9ab9f98d
ToppCellMS-IIF-Lymphocyte-B-B_intermediate|IIF / Disease, condition lineage and cell class

AP1S3 SIPA1L3 PKHD1L1 JUN CD22 BTK DNAH8

2.24e-051981897d6b533c5e1d55e13b1e87ce3dbacb1564bcdcc64
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWA3A PDE2A CYB5RL SYNE1 DOCK9 PKHD1L1 MMRN1

2.24e-05198189799d6a64f3410dae3019161feef20a8f06081a24b
ToppCellControl-Control-Lymphocyte-T/NK-CD4+_T_activated|Control / Disease, condition lineage and cell class

RASGRF2 DOCK9 IFIT3 LRIG1 HAPLN3 HERC6 HERC5

2.24e-051981897ee71543559836fd59adc0da877b2ca538cba60cb
DrugAC1L1B3Z

JUN DST MAPK9 CDC25B MAPK10 TP53BP2

1.82e-06451886CID000001273
DrugGN8

PRND PPP1R3A SLC25A43

2.20e-0641883CID016122598
Drugphenylglyoxylic acid

PNMA1 SYNE1 PRND PLEKHM1 PNMA2

3.68e-06291885CID000011915
Drug2f4b

TBPL1 SPTLC1 PPARG USP6

1.58e-05191884CID006102812
DrugAC1L3ZTY

JUN MAPK9 MAPK10

1.89e-0571883CID000098120
DrugAA100

JUN MAPK9 MAPK10

1.89e-0571883CID010490261
Drugcannabinol

APOE HNRNPH3 JUN ASMT

1.97e-05201884CID000002543
DrugBW245C

PPARG PTGDS PGD SLCO2A1 HTT

2.14e-05411885CID000119304
DrugCyclizine hydrochloride [303-25-3]; Down 200; 13.2uM; PC3; HT_HG-U133A

ZNF93 GRK5 ZNF576 CEMIP GRK2 CD22 NFIX OR1G1 ABHD8

3.98e-0519718895100_DN
DrugIndapamide [26807-65-8]; Up 200; 10.6uM; HL60; HT_HG-U133A

SIPA1L3 BAZ1B ATP10B PTGDS INO80D PAICS MTUS1 CD22 HERC6

3.98e-0519718892361_UP
Drug2-propylpentanoic acid; Down 200; 500uM; MCF7; HT_HG-U133A

SLC11A2 SIPA1L3 JUN MTUS1 CD22 SLCO2A1 CZIB UTY HERC5

3.98e-0519718895600_DN
DrugC75; Up 200; 10uM; MCF7; HT_HG-U133A

NPHP1 HTR2A USP29 ATP10B APOE ITGB3 IFIT3 CLCA2 FGF9

3.98e-0519718896423_UP
DrugGuanethidine sulfate [60-02-6]; Up 200; 13.4uM; PC3; HT_HG-U133A

ZNF93 PDE2A HTR2A GRK5 ITGB3 MMRN1 BTK ABHD8 CPLANE1

4.30e-0519918895731_UP
DrugBenfotiamine [22457-89-2]; Up 200; 8.6uM; MCF7; HT_HG-U133A

PDE2A ATP10B HNRNPH1 PPP1R3A GRK2 SLCO2A1 CD40LG FGF9 CBX2

4.48e-0520018896032_UP
DrugAC1L6EKE

JUN MAPK9 MAPK10

4.49e-0591883CID000265720
Drugvanadyl

PDE2A PIKFYVE JUN MTMR4 GRK2 GRK3 MTUS1 CD22 MAPK9 MAPK10 DNAH8

5.22e-0530718811CID000061671
DrugJS-K

JUN MAPK9 MAPK10

6.37e-05101883CID009572720
DrugD-JNKI-1

JUN MAPK9 MAPK10

6.37e-05101883ctd:C478085
Drughydroxysafflor yellow A

PPARG ITGB3 CD40LG

6.37e-05101883ctd:C085278
DrugKinome_3024

MAPK9 MAPK10

6.78e-0521882CID011539329
DrugN-acetyl-S-(2-hydroxy-2-phenylethyl)-L-cysteine

PNMA1 PNMA2

6.78e-0521882CID000119069
DrugAC1NSWD2

SYNE1 TOP2B

6.78e-0521882CID005318091
Drug7-hydroxy-6-methoxyphthalide

PNMA1 PNMA2

6.78e-0521882CID000152995
DrugNSC636979

IARS1 LARS1

6.78e-0521882CID000367344
DrugKinome_3019

MAPK9 MAPK10

6.78e-0521882CID011658882
Drug6-hydroxy-7-methoxyphthalide

PNMA1 PNMA2

6.78e-0521882CID000196075
DrugKinome_3025

MAPK9 MAPK10

6.78e-0521882CID011715520
DrugN-acetyl-S-(1-phenyl-2-hydroxyethyl)cysteine

PNMA1 PNMA2

6.78e-0521882CID000119298
DrugKinome_3027

MAPK9 MAPK10

6.78e-0521882CID011640926
DrugKinome_3028

MAPK9 MAPK10

6.78e-0521882CID011590363
DiseaseDrug habituation

SYNE1 FHOD3 XKR4 CSMD3 MKNK1 EHHADH DNAH8

7.57e-061151827C0013170
DiseaseDrug abuse

SYNE1 FHOD3 XKR4 CSMD3 MKNK1 EHHADH DNAH8

7.57e-061151827C0013146
DiseasePrescription Drug Abuse

SYNE1 FHOD3 XKR4 CSMD3 MKNK1 EHHADH DNAH8

7.57e-061151827C4316881
DiseaseSubstance-Related Disorders

SYNE1 FHOD3 XKR4 CSMD3 MKNK1 EHHADH DNAH8

7.57e-061151827C0236969
DiseaseDrug Use Disorders

SYNE1 FHOD3 XKR4 CSMD3 MKNK1 EHHADH DNAH8

7.57e-061151827C0013222
DiseaseDrug Dependence

SYNE1 FHOD3 XKR4 CSMD3 MKNK1 EHHADH DNAH8

7.57e-061151827C1510472
DiseaseSubstance Dependence

SYNE1 FHOD3 XKR4 CSMD3 MKNK1 EHHADH DNAH8

7.57e-061151827C0038580
DiseaseSubstance Use Disorders

SYNE1 FHOD3 XKR4 CSMD3 MKNK1 EHHADH DNAH8

7.57e-061151827C0038586
DiseaseOrganic Mental Disorders, Substance-Induced

SYNE1 FHOD3 XKR4 CSMD3 MKNK1 EHHADH DNAH8

7.57e-061151827C0029231
DiseaseSubstance abuse problem

SYNE1 FHOD3 XKR4 CSMD3 MKNK1 EHHADH DNAH8

8.01e-061161827C0740858
Diseasechemotherapy-induced alopecia, response to antimicrotubule agent

ME3 ZNF462 SERPINB12

3.67e-05111823EFO_0005260, EFO_0005400
DiseaseINSULIN RESISTANCE, SEVERE, DIGENIC

PPARG PPP1R3A

3.78e-0521822C4016701
DiseaseBipolar Disorder

HTR2A SYNE1 DOCK9 APOE PTGDS GRK3 EHHADH NFIX ASMT CLEC10A DNAH8

1.97e-0447718211C0005586
DiseaseAlzheimer disease, dementia, family history of Alzheimer’s disease

FHOD3 APOE ASB3 EGFLAM

2.20e-04481824EFO_0009268, MONDO_0001627, MONDO_0004975
Diseasehereditary sensory neuropathy (implicated_via_orthology)

SPTLC1 DST

3.74e-0451822DOID:0050548 (implicated_via_orthology)
Diseasecortical thickness

FNIP2 FLNB DOCK9 APOE FMNL2 RAB44 PLEKHM1 ZNF462 NPRL2 BAZ1A NFIX PYGB DMRTA1 DIAPH3 EBNA1BP2 MYO16 EPHA7

5.60e-04111318217EFO_0004840
DiseaseTYPE 2 DIABETES MELLITUS

GPD2 PPARG PPP1R3A

6.75e-04281823125853
DiseaseType 2 diabetes mellitus

GPD2 PPARG PPP1R3A

6.75e-04281823cv:C0011860
Diseaselongevity, healthspan, parental longevity

APOE FLACC1 HTT

7.49e-04291823EFO_0004300, EFO_0007796, EFO_0009762
Diseasehippocampus volume change measurement, age at assessment

APOE A2ML1 DIAPH3

7.49e-04291823EFO_0008007, EFO_0021492
Diseaseatherosclerosis (implicated_via_orthology)

APOE CD40LG

7.79e-0471822DOID:1936 (implicated_via_orthology)
DiseaseParkinson's disease (biomarker_via_orthology)

GRK5 GRK2 GRK3

8.29e-04301823DOID:14330 (biomarker_via_orthology)
Diseaseresponse to statin, low density lipoprotein cholesterol measurement

APOE CEMIP

1.03e-0381822EFO_0004611, GO_0036273
DiseaseWilliams Syndrome

BAZ1B LIMK1

1.03e-0381822C0175702
DiseaseMalignant neoplasm of breast

FLNB PDE2A WARS1 RASGRF2 SYNE1 EFCAB13 SPTLC1 OBSCN PPP1R3A CCNH JUN CLCA2 BTK FLACC1 HSPA14 TP53BP2

1.06e-03107418216C0006142
Diseasehyperuricemia

SIPA1L3 BAZ1B LRIG1

1.10e-03331823EFO_0009104
Diseasepancreatitis (implicated_via_orthology)

HTR2A PPARG

1.32e-0391822DOID:4989 (implicated_via_orthology)
DiseaseCardiovascular Diseases

GRK5 APOE GRK2

1.42e-03361823C0007222
DiseaseMetabolic Diseases

HTR2A PPARG

1.65e-03101822C0025517
Diseasetranscription factor IIIb 90 kda subunit measurement

PIKFYVE EHHADH

1.65e-03101822EFO_0020778
Diseaseresponse to carboplatin, response to antineoplastic agent

FLNB LRIG1

1.65e-03101822GO_0097327, GO_0097328
Diseasecongestive heart failure (is_marker_for)

GRK5 GRK2 GRK3 CD40LG

1.68e-03821824DOID:6000 (is_marker_for)
Diseaseglomerulosclerosis (implicated_via_orthology)

PPARG APOE

2.01e-03111822DOID:0050851 (implicated_via_orthology)
Diseasecytochrome p450 3a4 measurement

APOE PIKFYVE

2.01e-03111822EFO_0020303
DiseaseCongenital ichthyosis of skin

CASP14 SDR9C7

2.01e-03111822cv:C0020758
Diseaseoleoyl-linoleoyl-glycerol (18:1/18:2) [1] measurement

BAZ1B APOE

2.01e-03111822EFO_0800332
Diseaseairway wall thickness measurement

AP1S3 SDR9C7

2.40e-03121822EFO_0006898
Diseaseamyloid plaque accumulation rate

UBR3 IL1RAP

2.40e-03121822EFO_0007646
DiseaseRAC-beta serine/threonine-protein kinase measurement

APOE EHHADH

2.82e-03131822EFO_0021989
Diseaseskin melanoma (is_marker_for)

DDR1 AFF4

2.82e-03131822DOID:8923 (is_marker_for)
Diseasetransient cerebral ischemia (biomarker_via_orthology)

PPARG APOE ITGB3 CCNH HTT

2.96e-031571825DOID:224 (biomarker_via_orthology)
Diseaselung carcinoma

DDR1 OGDH FRY MTUS1 ASB3 BRD9 HAPLN3 DMRTA1 IL1RAP

3.17e-034821829EFO_0001071
Diseaseglucose-dependent insulinotropic peptide measurement, glucose tolerance test

BTNL3 CLEC10A

3.28e-03141822EFO_0004307, EFO_0008464
DiseaseWilliams-Beuren syndrome (implicated_via_orthology)

BAZ1B LIMK1

3.77e-03151822DOID:1928 (implicated_via_orthology)
Diseaseautoimmune thrombocytopenic purpura (is_implicated_in)

ITGB3 CD40LG

3.77e-03151822DOID:8924 (is_implicated_in)
Diseasepancreatic adenocarcinoma (is_implicated_in)

MAPK9 MAPK10

3.77e-03151822DOID:4074 (is_implicated_in)
Diseaseinterferon gamma measurement

EFCAB13 ZNF767P EPHA8

3.87e-03511823EFO_0008165
DiseaseInfluenza

IFIT3 HERC6 HERC5

4.09e-03521823C0021400
DiseaseColorectal Carcinoma

SLC11A2 RASGRF2 SYNE1 OBSCN IPP PPARG CSMD3 SLCO2A1 DMRTA1 DNAH8 EPHA7

4.38e-0370218211C0009402
DiseaseRenal Insufficiency

PPARG APOE

4.84e-03171822C1565489
Diseaseglycochenodeoxycholate measurement

CEMIP GRK2

4.84e-03171822EFO_0010490
Diseaseglutarylcarnitine (C5-DC) measurement

FNIP2 CZIB

4.84e-03171822EFO_0800030
Diseasehyperglycemia (implicated_via_orthology)

HTR2A GRK2

4.84e-03171822DOID:4195 (implicated_via_orthology)
DiseasePsoriasis

AP1S3 PPARG APOE

5.29e-03571823C0033860
DiseasePustulosis of Palms and Soles

AP1S3 PPARG APOE

5.29e-03571823C0030246
Diseasecup-to-disc ratio measurement

ARHGAP42 FLNB EFCAB13 FHOD3 FMNL2 TGFBR3 MTUS1 MYO16

5.41e-034301828EFO_0006939
DiseaseSjogren's syndrome (is_implicated_in)

APOE HNRNPH1

5.42e-03181822DOID:12894 (is_implicated_in)
Diseaseinsulin resistance

PPARG KCNU1 DMRTA1

5.82e-03591823EFO_0002614
DiseaseCarcinoma, Granular Cell

DDR1 PPARG APOE FGF9

5.86e-031161824C0205644
DiseaseAdenocarcinoma, Tubular

DDR1 PPARG APOE FGF9

5.86e-031161824C0205645
DiseaseAdenocarcinoma, Oxyphilic

DDR1 PPARG APOE FGF9

5.86e-031161824C0205642
DiseaseCarcinoma, Cribriform

DDR1 PPARG APOE FGF9

5.86e-031161824C0205643
DiseaseAdenocarcinoma, Basal Cell

DDR1 PPARG APOE FGF9

5.86e-031161824C0205641
DiseaseAdenocarcinoma

DDR1 PPARG APOE FGF9

5.86e-031161824C0001418
DiseaseLipoidosis

PPARG AP1S1

6.04e-03191822C0023794
Diseasep-tau:beta-amyloid 1-42 ratio measurement

APOE EPHA7

6.04e-03191822EFO_0007709
Diseaseinsulin sensitivity measurement, body mass index

PPARG FGF9

6.04e-03191822EFO_0004340, EFO_0004471
Diseaseovulation

PLEKHM1 RLBP1

6.04e-03191822GO_0030728

Protein segments in the cluster

PeptideGeneStartEntry
FCFLAVGLVDVKVTQ

TRBV28

11

A0A5B6
KFVQALVGEDAVFSC

BTNL3

26

Q6UXE8
LLFKDFCLNEINEAV

GRK3

66

P35626
AEGGFTQIKCNTDIF

EGFLAM

721

Q63HQ2
NDFLKGCATLQVEIF

ARHGEF6

71

Q15052
TFLAGCQAKVEQAVE

APOE

11

P02649
LACKVDEFNVSSPQF

CCNH

111

P51946
QFGFELIGEKSIVCQ

CSMD3

691

Q7Z407
LLNCEEIKSQFEGFV

CD40LG

81

P29965
ETGVQCALSLQEFVK

BRD9

416

Q9H8M2
NCLVNDQGVVKVSDF

BTK

526

Q06187
KDFGECVIALQASVI

BAZ1B

1091

Q9UIG0
NCLVGENFTIKIADF

DDR1

771

Q08345
GSEKLTQECVFREQF

FGF9

126

P31371
VTKCFGQAQKFIFID

A2ML1

1041

A8K2U0
VFKEGSCLLADDNFV

HTR2A

221

P28223
SNEQKACKVLGIVFF

HTR2A

316

P28223
GSVCELDIIFNFEKA

AP1S1

96

P61966
GFVVCAFNRTVSKVD

PGD

26

P52209
VPTFELTLVFKQENC

DDIT4L

131

Q96D03
KQETAVNIGFACELL

ATP8B3

766

O60423
CVNVLLEFGAKAQLE

ASB11

146

Q8WXH4
VSQVLFAACELGVFD

ASMT

21

P46597
QFVDICIDQAKLEEF

DIAPH3

491

Q9NSV4
NIQNCTFRKFVALEG

CEMIP

886

Q8WUJ3
QVCKFLVESGAAVFA

TP53BP2

1006

Q13625
RCVVKGFSQQEVQFE

ATP10B

216

O94823
ITSCKGAQADVVLFF

ABHD8

166

Q96I13
NGFKEFTRQEQINCV

BAZ1A

751

Q9NRL2
VVSFIECGNALEKNA

AFF4

946

Q9UHB7
EEICQNLRGDVFQKF

GRK2

151

P25098
EELFSQVGPVKQCFV

RBM28

21

Q9NW13
GDKTISFNNCIVQLF

OR6C1

86

Q96RD1
AELQAFFQDCGAKER

RAB44

46

Q7Z6P3
AKCVQANAFIQAGIF

RAD1

56

O60671
FCDVQLQVGQESFKA

IPP

36

Q9Y573
CNEKDIVDFFAGLNI

GRSF1

261

Q12849
ECKIQFFSIAIGVTT

OR5H15

96

A6NDH6
GNVCELDIIFNFEKA

AP1S3

96

Q96PC3
EELGFQLFCNIIKSQ

CFAP99

96

D6REC4
CAAFDTVLGINVAVK

MAPK9

41

P45984
VNSLEGCQLIKFDSV

FAM189A1

121

O60320
VLIKLACVGTTFNEA

OR2G2

186

Q8NGZ5
VLAQVFTELAQKGFC

MDN1

4641

Q9NU22
GQDSLKEFVQFVCSD

NFIX

396

Q14938
GQEFDVRAKCVINAT

GPD2

276

P43304
FGQVVADVLCEFLEV

MAD2L2

11

Q9UI95
SVIFIKGNCASEEVI

MAGEC3

281

Q8TD91
CQEDDATIAKVGQLF

HAPLN3

286

Q96S86
VKIAFCQGFDKQVDV

MAPK10

16

P53779
SFVCDDFLKPQIITQ

LRIG1

486

Q96JA1
CSAVFENFIQEKEEL

FLACC1

281

Q96Q35
LACGNTKFEALTVVI

MTUS1

926

Q9ULD2
IIVETNVGKQFNFCS

PNLIP

436

P16233
GFEEFQKNEFEQLCV

MYO16

781

Q9Y6X6
AFPLEVVQKDSCFNS

IL1RAP

126

Q9NPH3
QFLCPKNVTDEQEGF

JUN

96

P05412
FTGDNCTIKLVEENA

MMRN1

1071

Q13201
QQALCNAKIFGEDEV

DST

5606

Q03001
QVFAELSAVCKPEAF

EHHADH

391

Q08426
AVNDVNGLKQCLAEF

EBNA1BP2

46

Q99848
EKSGCIVNNLAEFTV

FLNB

656

O75369
DQVVALACAFNKLEG

PDE2A

341

O00408
ASCGFLENVILAQKF

DNAH8

1986

Q96JB1
QAEATDFCKVLVVEF

HERC6

691

Q8IVU3
NENDETFVTLVGCFK

CYB5RL

206

Q6IPT4
GKFSNIVDKFVIVDC

CDC25B

426

P30305
GCSKEEIVQFFQGLE

HNRNPH3

26

P31942
AFFGKTNEQVVEVCT

SLC11A2

321

P49281
NIICFAELKLGFIAQ

KCNU1

471

A8MYU2
GLCTFLTSLFVEQNK

KCNU1

491

A8MYU2
EECLEAFKQVFGSLE

PNMA2

231

Q9UL42
EVQRFFSDCKIQNGA

HNRNPH1

26

P31943
VLIDGVECSDVKFFQ

PACS2

851

Q86VP3
FKNVESVAEIFDCLG

OC90

46

Q02509
EKIAEDQTCFFLQIL

RALGAPA2

201

Q2PPJ7
FQDVGACIALVSVKV

EPHA7

186

Q15375
CLFEFNEAFLVKLVQ

MTMR4

486

Q9NYA4
CKIFQTLNGAVDEVV

PLOD2

216

O00469
ECFLLGFSEQLEEQK

OR1G1

11

P47890
CDGETDQFSFKIVLV

PPP1R3A

181

Q16821
LIEGLDNQKVEFVAC

HERC5

236

Q9UII4
EDIKICDFGFAQNIT

OBSCN

6601

Q5VST9
FEQDFLTIGDLQLCK

PANK2

321

Q9BZ23
LEQIFCQFDSKLEAA

OGDH

326

Q02218
VDQKFQSIVIGCALE

BAG2

151

O95816
FDSVVVNGFVCTKNI

PIKFYVE

676

Q9Y2I7
NKECQDDFGITPLFV

ASB3

171

Q9Y575
NCLFNKGETFEVPEI

ATR

2496

Q13535
GKLEQVDVNLFCLVA

HTT

3081

P42858
FVEDENKFIFCNVLV

HYDIN

3361

Q4G0P3
DFCKVFLISGVTLDN

KLHL13

181

Q9P2N7
SVGEQVFAAECILSK

CBX2

6

Q14781
LKEVFRQFVEACGQA

DOCK9

2016

Q9BZ29
QVLAACFTEEGSQKL

SDR9C7

51

Q8NEX9
VVNAVFIKNELFGDC

CPLANE1

181

Q9H799
GGLKQTVCFINFIDN

ELOVL3

96

Q9HB03
IFSLCEKEEAQRNFQ

FNIP2

316

Q9P278
VLVDSNLVCKVSDFG

EPHA8

766

P29322
FCKGDVVQAIEQVLN

DMRTA1

351

Q5VZB9
EVNINKFCRIISEFA

FHOD3

1236

Q2V2M9
GFCNVILVKEENTRF

GPAT2

71

Q6NUI2
DRVCNQIEFLNTEFK

IFIT3

36

O14879
EIILSAFDNFKEVCG

FMNL2

281

Q96PY5
TVDIDAFQDALKIFC

EFCAB13

216

Q8IY85
AVTDKFGINCLIQFE

ME3

266

Q16798
SEFLCLEFDEVKVNQ

COMMD1

156

Q8N668
KFADGQQCSVPVFDI

INO80D

486

Q53TQ3
GFKDSLIVQVTFDCD

ITGB3

446

P05106
VEGFALVLLCSFQVA

FRY

741

Q5TBA9
IETECFKELNVFGPN

GRK5

516

P34947
DQKGSCFIQTLVDVF

CASP14

181

P31944
LVFLTGQFEIEKSCE

DHX40

276

Q8IX18
TAECLKALEQVFGSV

PNMA1

226

Q8ND90
NVPVENFFVKCNGAL

SDE2

41

Q6IQ49
LFQVRKVCAANFGDI

PPP4R1L

176

Q9P1A2
KGEKFQVTIIADDNC

BVES

211

Q8NE79
ETLQFCVIFQPTKAE

CFAP74

976

Q9C0B2
NENFKTIVEFECRGL

CZIB

91

Q9NWV4
IVTCQLQDADGKFLS

CD22

216

P20273
VQKAISEAGIFCLVN

NPHP1

251

O15259
QNGFTADDINKVVLC

HSPA14

321

Q0VDF9
LCFSVNGVFKEVEGQ

NXF2

496

Q9GZY0
CQGNKNILELIEFFE

MKNK1

101

Q9BUB5
NTDVNEFVIFICGVL

OR10R2

211

Q8NGX6
GSLDENCQEVLKFAT

PLEKHM1

791

Q9Y4G2
NCQEVLKFATRENGF

PLEKHM1

796

Q9Y4G2
LFAEAQITFQTKGCI

RTEL1

351

Q9NZ71
VENAKDIIACGFDIN

WARS1

216

P23381
DIIACGFDINKTFIF

WARS1

221

P23381
NQVKGIFGFTDSDCI

WARS1

261

P23381
ILKAEGKVESDFFCQ

UTY

81

O14607
CLTLSEKGFQQISFV

TOP2B

321

Q02880
FIQEKAKVVTFDCGN

SLC9C1

881

Q4G0N8
DVCSAVGLNVFLEKN

SRP19

51

P09132
LLQGKAEDCFQLFEE

SYNE1

1841

Q8NF91
SIVGCKAILIDDQVF

LGI2

276

Q8N0V4
EGTFLALVEQKVCSA

NBPF7P

341

P0C2Y1
NEAGFNFVRKCIQAV

ARHGAP42

391

A6NI28
ECSALQQDGVKEVFA

RHOG

156

P84095
GFNNTERTCDKEFII

RASGRF2

896

O14827
FETVNGDIFICTQKA

LARS1

316

Q9P2J5
QSKEVAIRIFQGCQF

PPARG

301

P37231
NVTGVDCVKGIVSFF

SLC9A3

241

P48764
FCKAQGFTEDTIVFL

PTGDS

166

P41222
QAASEQLRKFAEIFC

SIPA1L3

1761

O60292
NKLTQFFICVAGVFV

SLC35B3

76

Q9H1N7
IIKENFALECSPAFQ

SGO2

1171

Q562F6
FVLAIFCKRVNEQGA

SLC5A4

471

Q9NY91
FLKCKENGAFTVLVD

IARS1

296

P41252
FSGAVDCFRQIVKAQ

SLC25A43

246

Q8WUT9
GFQECIKGNVDLVFL

ITGAL

146

P20701
LLFNLGFVCDAQAKT

NPRL2

81

Q8WTW4
TANVEFCLDVFKELN

SERPINB11

6

Q96P15
FCLDVFKELNSNNIG

SERPINB11

11

Q96P15
TANTKFCFDLFQEIG

SERPINB12

6

Q96P63
FVDRAACFAIQKGLQ

SPTLC1

186

O15269
FGNCNGLAVVDFIQK

STXBP5L

656

Q9Y2K9
VFQSLDGIVVSANCK

CFAP20DC

26

Q6ZVT6
CVVGFQNSKFQRDLV

CLEC10A

56

Q8IUN9
TFSLVQAGDKVVCLV

CLCA2

301

Q9UQC9
SVFGNIKVFVLCQGL

SLCO2A1

26

Q92959
LADCEKTAVEFGNQL

ZNF767P

46

Q75MW2
SEEQLIAAKFCFAGL

PAICS

141

P22234
CGSFQEFVEKENLQP

TIGD2

156

Q4W5G0
VCAFDLTQVAAVFEG

SEMA6B

336

Q9H3T3
IFTDFKVVNVLAVCN

TBPL1

96

P62380
IECGKAFNQFSTLIT

ZNF93

176

P35789
ELCVFTIFGNEENGK

ZDHHC20

36

Q5W0Z9
TLFKIGEQFSVLGQC

ZNF778

161

Q96MU6
SCDRIKEEFQFLQAQ

TLE4

31

Q04727
DKVEGRKFFVSCNVQ

THEM4

201

Q5T1C6
EANVTKEAFVTGCIN

PRND

96

Q9UKY0
DFNKFILCNLTVEAV

TRIL

581

Q7L0X0
EDIAQGTKCTLEFQV

TMED7

51

Q9Y3B3
CFETFPDKVAIQLND

PYGB

326

P11216
QKFAERDGCVPVFQV

XKR4

561

Q5GH76
ANFEFELQLSLICKA

USP29

426

Q9HBJ7
FSLGCTEEEVQKFVL

MTERF1

301

Q99551
LQFVAKQGACFEVIL

PHOSPHO1

106

Q8TCT1
KQGACFEVILISDAN

PHOSPHO1

111

Q8TCT1
VGVESDFDFCQTAIK

THNSL1

431

Q8IYQ7
NVGFIAFDKACNLDV

RIMKLB

281

Q9ULI2
KAVAQFVLETEDCVF

REP15

196

Q6BDI9
EETQINGFCIIENFK

RLBP1

191

P12271
FKNVCSGETNVIFIT

PKHD1L1

3616

Q86WI1
EKLIQFCAIDELGTN

SAP30BP

166

Q9UHR5
CQIVNVAAEIFLKSG

TOPAZ1

1411

Q8N9V7
QVLQGFSVDKGEFTC

UBR3

1346

Q6ZT12
GIDFSLKNETVAICV

ZNF462

2476

Q96JM2
FVAQKLQGVLFICFT

ZNF576

61

Q9H609
LADCEKTAVEFGNQL

ZNF746

46

Q6NUN9
CGFVFDDVSAILDNK

TMTC3

26

Q6ZXV5
KVQLSVSGFLCAFEI

USP6

781

P35125
CSKALEFQVPLVFNE

WWC3

656

Q9ULE0
VLEEGTNVVQKICFS

VWA3A

116

A6NCI4
TKAEQELGFAIQTCF

TGFBR3

626

Q03167
NILVGENLVCKIADF

YES1

401

P07947
CLVRENKNVVVADFG

LIMK1

466

P53667