Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	CHD8 RAD17 WRN	1.19e-03	127	33	3	GO:0008094
GeneOntologyMolecularFunction	DNA secondary structure binding	MAPT WRN	2.09e-03	41	33	2	GO:0000217
GeneOntologyMolecularFunction	structural constituent of synapse	MAGI2 RIMS2	2.19e-03	42	33	2	GO:0098918
GeneOntologyMolecularFunction	protein serine/threonine/tyrosine kinase activity	TTK DYRK2	2.73e-03	47	33	2	GO:0004712
GeneOntologyMolecularFunction	structural molecule activity	JPH1 MRPS9 MAGI2 COPG2 MACROH2A1 RIMS2	3.06e-03	891	33	6	GO:0005198
GeneOntologyMolecularFunction	ATP-dependent activity	ACSL3 CHD8 KIF26B RAD17 WRN	3.15e-03	614	33	5	GO:0140657
GeneOntologyMolecularFunction	3'-5' exonuclease activity	DIS3 WRN	4.56e-03	61	33	2	GO:0008408
GeneOntologyMolecularFunction	DNA helicase activity	CHD8 WRN	4.71e-03	62	33	2	GO:0003678
GeneOntologyMolecularFunction	manganese ion binding	DYRK2 WRN	6.13e-03	71	33	2	GO:0030145
GeneOntologyMolecularFunction	chromatin binding	CHD8 MACROH2A1 ZNF609 RAD17 WRN	6.88e-03	739	33	5	GO:0003682
Domain	P-loop_NTPase	MAGI2 CHD8 RRAGB SAMD9 KIF26B RAD17 WRN	5.88e-04	848	33	7	IPR027417
Domain	PDZ	MAGI2 GRID2IP RIMS2	1.95e-03	141	33	3	PF00595
Domain	DEAH_ATP_HELICASE	CHD8 WRN	2.05e-03	38	33	2	PS00690
Domain	PDZ	MAGI2 GRID2IP RIMS2	2.23e-03	148	33	3	SM00228
Domain	-	MAGI2 GRID2IP RIMS2	2.32e-03	150	33	3	2.30.42.10
Domain	PDZ	MAGI2 GRID2IP RIMS2	2.37e-03	151	33	3	PS50106
Domain	PDZ	MAGI2 GRID2IP RIMS2	2.41e-03	152	33	3	IPR001478
Domain	-	CHD8 RRAGB SAMD9 RAD17 WRN	9.41e-03	746	33	5	3.40.50.300
Domain	Helicase_C	CHD8 WRN	1.53e-02	107	33	2	PF00271
Domain	HELICc	CHD8 WRN	1.53e-02	107	33	2	SM00490
Domain	Helicase_C	CHD8 WRN	1.56e-02	108	33	2	IPR001650
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CEP350 AMER1 TTK MAPT KIF26B PRRC2C PI4KA DYRK2	1.10e-06	861	33	8	36931259
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	CEP350 ZC3H6 FAM81B KIF26B DIS3 TPRN RAD17	3.17e-06	689	33	7	36543142
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	CEP350 MRPS9 COPG2 AMER1 ANKRD50 PI4KA WRN	6.96e-06	777	33	7	35844135
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	MRPS9 ACSL3 MAGI2 FRMD4A MACROH2A1 MAPT PRRC2C PI4KA	8.64e-06	1139	33	8	36417873
Pubmed	Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex.	RIMS2 MAPT	8.72e-06	5	33	2	22553025
Pubmed	RIM1/2 in retinal ganglion cells are required for the refinement of ipsilateral axons and eye-specific segregation.	RIMS2 MAPT	8.72e-06	5	33	2	28607399
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	RBM6 TTK DIS3 PRRC2C PI4KA TPRN	1.71e-05	588	33	6	38580884
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	ACSL3 AMER1 TTK DIS3 PRRC2C PI4KA	2.03e-05	606	33	6	36538041
Pubmed	The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase.	MAPT DYRK2	2.44e-05	8	33	2	11311121
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	CHD8 ZNF609 SAMD9 ANKRD50 DIS3 PRRC2C	3.00e-05	650	33	6	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	RBM6 ACSL3 COPG2 CHD8 DIS3 PRRC2C	3.08e-05	653	33	6	22586326
Pubmed	FRMD4A-cytohesin signaling modulates the cellular release of tau.	FRMD4A MAPT	3.13e-05	9	33	2	27044754
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	RPF1 COPG2 AMER1 ANKRD50 DIS3 PI4KA RAD17	5.89e-05	1084	33	7	11544199
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	MRPS9 CHD8 MACROH2A1 PRRC2C	9.19e-05	251	33	4	31076518
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CHD8 ZNF609 ANKRD50 RIMS2 DIS3	1.33e-04	529	33	5	14621295
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	JPH1 ACSL3 COPG2 TTK PRRC2C	1.86e-04	568	33	5	37774976
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	MRPS9 COPG2 CHD8 MACROH2A1 TTK DIS3 WRN	1.99e-04	1318	33	7	30463901
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	RBM6 COPG2 CHD8 MACROH2A1 ZNF609 PRRC2C	2.46e-04	954	33	6	36373674
Pubmed	Substrate specificities and identification of putative substrates of ATM kinase family members.	RAD17 WRN	2.58e-04	25	33	2	10608806
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	JPH1 RBM6 COPG2 MACROH2A1 TTK MAPT	3.29e-04	1007	33	6	34597346
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	CEP350 ACSL3 COPG2 ZNF609 PI4KA TPRN	4.09e-04	1049	33	6	27880917
Pubmed	p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.	CEP350 MRPS9 ACSL3	4.63e-04	159	33	3	30581152
Pubmed	Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation.	MAGI2 GRID2IP	4.81e-04	34	33	2	30726710
Pubmed	Host PDZ-containing proteins targeted by SARS-CoV-2.	MAGI2 RIMS2	5.09e-04	35	33	2	33864728
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	JPH1 COPG2 ANKRD50 TTK PRRC2C	5.10e-04	708	33	5	39231216
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	RBM6 ACSL3 MACROH2A1 DIS3 PRRC2C	5.30e-04	714	33	5	28302793
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	CEP350 ZNF609 TTK MAPT PRRC2C	5.64e-04	724	33	5	36232890
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	JPH1 CHD8 MACROH2A1 ZNF609 MAPT TPRN	5.68e-04	1116	33	6	31753913
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	MRPS9 ACSL3 FRMD4A PI4KA WRN	5.93e-04	732	33	5	34732716
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	CEP350 MRPS9 ACSL3 COPG2 ZNF609	6.78e-04	754	33	5	33060197
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	RBM6 RPF1 MACROH2A1 PRRC2C WRN	6.99e-04	759	33	5	35915203
Pubmed	Defining the membrane proteome of NK cells.	CEP350 ACSL3 TTK DIS3 PRRC2C PI4KA	7.21e-04	1168	33	6	19946888
Pubmed	Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4.	JPH1 ACSL3 COPG2	7.88e-04	191	33	3	31177093
Pubmed	Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase.	RBM6 ZC3H6 KIF26B	8.74e-04	198	33	3	24337577
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	RBM6 ZNF609 DIS3 PRRC2C	8.90e-04	457	33	4	32344865
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	PRRC2C PI4KA WRN	9.26e-04	202	33	3	33005030
Interaction	YWHAH interactions	CEP350 FRMD4A AMER1 GRID2IP RIMS2 TTK MAPT KIF26B PRRC2C PI4KA	6.69e-06	1102	33	10	int:YWHAH
Interaction	TTBK1 interactions	ACSL3 MAGI2 MAPT	1.42e-05	29	33	3	int:TTBK1
GeneFamily	PDZ domain containing	MAGI2 GRID2IP RIMS2	4.33e-04	152	18	3	1220
Coexpression	LAKE_ADULT_KIDNEY_C5_PROXIMAL_TUBULE_EPITHELIAL_CELLS_STRESS_INFLAM	RBM6 FRMD4A RIMS2 ZC3H6 MAPT KIF26B PRRC2C CFDP1	3.76e-08	417	33	8	M39224
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_top-relative-expression-ranked_1000	CEP350 FRMD4A RIMS2 ZC3H6 MAPT KIF26B PRRC2C WRN	1.68e-05	818	31	8	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_top-relative-expression-ranked_500	CEP350 FRMD4A ZC3H6 MAPT KIF26B WRN	3.07e-05	427	31	6	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_500
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_k-means-cluster#1_top-relative-expression-ranked_1000	ACSL3 COPG2 TTK DIS3 RAD17	1.12e-04	333	31	5	gudmap_dev gonad_e13.5_M_GermCell_Oct_k1_1000
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_1000	ACSL3 COPG2 RIMS2 TTK ZC3H6 DIS3 RAD17	1.35e-04	810	31	7	gudmap_dev gonad_e13.5_M_GermCell_Oct_1000
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	CEP350 RIMS2 PRRC2C CFDP1	1.32e-05	197	33	4	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	(10)_Ciliated-(2)_GFP_FOXI1\|(10)_Ciliated / shred by cell type by condition	CEP350 MACROH2A1 SAMD9 PRRC2C	1.37e-05	199	33	4	61b1ed2db71b96157b92b7535d1955a4033098da
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_only / Treatment groups by lineage, cell group, cell type	FRMD4A MAPT CFDP1 DYRK2	1.40e-05	200	33	4	69edc375d85689300d1dbc1217fedc40063ecdcb
Drug	5-aza-2′-deoxycytidine; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA	MACROH2A1 RRAGB RIMS2 DIS3 AGXT	8.55e-06	195	33	5	920_UP
Drug	Felbinac [5728-52-9]; Down 200; 18.8uM; PC3; HT_HG-U133A	ZNF609 RRAGB SAMD9 MAPT DIS3	9.67e-06	200	33	5	4639_DN
Disease	osteoarthritis	RBM6 GRID2IP MAPT KIF26B	9.50e-05	222	32	4	MONDO_0005178
Disease	ocular sarcoidosis	FRMD4A KIF26B PRRC2C	2.70e-04	116	32	3	EFO_0010723
Disease	daytime rest measurement	FRMD4A MAPT KIF26B PRRC2C	2.82e-04	295	32	4	EFO_0007828
Disease	cognitive function measurement	RBM6 FRMD4A COPG2 SAMD9 PRRC2C CFDP1 WRN	7.28e-04	1434	32	7	EFO_0008354
Disease	Moyamoya disease	MAGI2 CFDP1	8.66e-04	40	32	2	MONDO_0016820
Disease	Memory Disorders	MAGI2 MAPT	1.00e-03	43	32	2	C0025261
Disease	Memory Loss	MAGI2 MAPT	1.00e-03	43	32	2	C0751295
Disease	Age-Related Memory Disorders	MAGI2 MAPT	1.00e-03	43	32	2	C0751292
Disease	Memory Disorder, Spatial	MAGI2 MAPT	1.00e-03	43	32	2	C0751294
Disease	Memory Disorder, Semantic	MAGI2 MAPT	1.00e-03	43	32	2	C0751293
Disease	Memory impairment	MAGI2 MAPT	1.05e-03	44	32	2	C0233794
Disease	Anxiety Disorders	MAGI2 MAPT	1.05e-03	44	32	2	C0003469
Disease	Anxiety neurosis (finding)	MAGI2 MAPT	1.05e-03	44	32	2	C1279420
Disease	Anxiety States, Neurotic	MAGI2 MAPT	1.05e-03	44	32	2	C0376280
Disease	monoclonal gammopathy	FRMD4A RIMS2	1.52e-03	53	32	2	EFO_0000203
Disease	type 1 diabetes mellitus	ANKRD50 MAPT PI4KA	2.27e-03	242	32	3	MONDO_0005147

Protein segments in the cluster

Peptide	Gene	Start	Entry
TSGASKTKGKSKLNT	CHD8	521	Q9HCK8
MSSRGGKKKSTKTSR	MACROH2A1	1	O75367
SGKGSSKKGLSKSKT	AMER1	81	Q5JTC6
SLKSTKASKGGKSEN	ANKRD50	1261	Q9ULJ7
KGMSLKSDAVLSKSK	RAD17	356	O75943
KGTFLSTTLKKSNMG	MAGI2	421	Q86UL8
MKKKKTKYTSSSSGG	KIF26B	801	Q2KJY2
MKLRKSESKSSISSK	JPH1	221	Q9HDC5
GMSTISKKSGMSKKT	PI4KA	1461	P42356
IKSTKNKAGKASIMS	FAM81B	26	Q96LP2
KSKKGGKMRQISLSS	RIMS2	531	Q9UQ26
TLKTSKLANMGSKGK	FRMD4A	346	Q9P2Q2
SLLGKIGAKKQKMST	CFDP1	226	Q9UEE9
SFKGKMGTVSKSRAS	GRID2IP	566	A4D2P6
SRSSTSSKGKKGKKE	CEP350	1166	Q5VT06
VSKMLNKFTKSGLKS	COPG2	211	Q9UBF2
SSTSLKSMEGMGKVK	DYRK2	136	Q92630
TSQGKSSSKKEMSKR	RBM6	836	P78332
GTSLISFSDKAKKKM	AGXT	216	P21549
SAMSTTAKGSKSLKV	SAMD9	126	Q5K651
MSEKSGQSTKAKDGK	PRRC2C	1	Q9Y520
RKMSSSGGKQKALST	OR7D2	226	Q96RA2
FAKGSDTSKKLMDKT	WRN	1411	Q14191
MLKSKTFLKKTRAGG	DIS3	1	Q9Y2L1
SSKIKKGSKGDTSML	ACSL3	361	O95573
MAKAGDKSSSSGKKS	RPF1	1	Q9H9Y2
GSSFSKESGKKQRMK	ZC3H6	186	P61129
GMAFSKSEGKRKTAK	MRPS9	266	P82933
GKSKSKRSKSGKDTS	ZNF609	86	O15014
TSRTGSSGAKEMKLK	MAPT	446	P10636
KKVLLMGKSGSGKTS	RRAGB	41	Q5VZM2
LTKAGSSRKKMKISF	TPRN	566	Q4KMQ1
KDMSSSRENGKSKSK	TTK	696	P33981