Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription coactivator activity

TRERF1 LPIN3 BCL9L KMT2D NACA APBB1 SRCAP CREBBP MED12

6.89e-06303879GO:0003713
GeneOntologyMolecularFunctionbeta-catenin binding

BCL9L TJP1 CHD8 NOS2 MED12 PTPRT

1.41e-05120876GO:0008013
GeneOntologyMolecularFunctionchromatin binding

TNRC18 ZC3H12A ATXN1 ZC3H4 FOS ASXL3 CHD5 APBB1 CHD8 CREBBP MED12 POLR3G

8.41e-057398712GO:0003682
GeneOntologyMolecularFunctiontranscription coregulator activity

TRERF1 LPIN3 BCL9L KMT2D NACA ATF7IP2 APBB1 SRCAP CREBBP MED12

1.65e-045628710GO:0003712
GeneOntologyMolecularFunctionRNA polymerase III type 3 promoter sequence-specific DNA binding

MTOR SNAPC4

2.78e-046872GO:0001006
GeneOntologyMolecularFunctionRNA polymerase III cis-regulatory region sequence-specific DNA binding

MTOR SNAPC4

3.89e-047872GO:0000992
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

TRERF1 LPIN3 MAGI2 BCL9L ZSWIM8 KMT2D TICAM1 NACA ATF7IP2 APBB1 SH2D2A SRCAP CREBBP MED12

4.66e-0411608714GO:0030674
GeneOntologyMolecularFunctionRNA polymerase III transcription regulatory region sequence-specific DNA binding

MTOR SNAPC4

5.17e-048872GO:0001016
GeneOntologyMolecularFunctionhistone H3K4 monomethyltransferase activity

KMT2D SETD1B

5.17e-048872GO:0140945
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase inhibitor activity

WASH3P RUBCN

5.17e-048872GO:0141039
GeneOntologyMolecularFunctionSMAD binding

MAGI2 FOS ZC3H3 CREBBP

5.44e-0486874GO:0046332
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

CHD5 CHD8 SRCAP

5.58e-0437873GO:0140658
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

KMT2D SETD1B

8.26e-0410872GO:0140999
GeneOntologyMolecularFunctiontranscription factor binding

TRERF1 MTOR FOS ZNF516 NACA MED25 APBB1 CREBBP MED12 PTPRT

1.60e-037538710GO:0008134
GeneOntologyMolecularFunctiontranscription coactivator binding

TRERF1 MED25 CREBBP

1.69e-0354873GO:0001223
GeneOntologyCellularComponentnuclear protein-containing complex

TRERF1 BCL9L ELOA KMT2D SETD1B PHF20 FOS ASXL3 CHD5 MED25 CHD8 SRCAP ZC3H3 CREBBP MED12 POLR3G

1.83e-0413778816GO:0140513
GeneOntologyCellularComponenthistone methyltransferase complex

KMT2D SETD1B PHF20 CHD8

2.84e-0475884GO:0035097
GeneOntologyCellularComponentfibrillar center

TRERF1 BCL9L ARHGAP32 RREB1 THAP1

5.17e-04156885GO:0001650
GeneOntologyCellularComponentNSL complex

PHF20 PHF20L1

9.40e-0411882GO:0044545
GeneOntologyCellularComponentmembrane coat

EPS15L1 SEC24C COPA AP5B1

1.05e-03106884GO:0030117
GeneOntologyCellularComponentcoated membrane

EPS15L1 SEC24C COPA AP5B1

1.05e-03106884GO:0048475
GeneOntologyCellularComponentcytoplasmic vesicle membrane

RAB12 WASH3P ARHGAP32 SNX4 MCTP1 SEC24C COPA KIF1A MAP6 TICAM1 DBH ULK1 FER1L5 CNGB1

1.08e-0313078814GO:0030659
GeneOntologyCellularComponentmethyltransferase complex

KMT2D SETD1B PHF20 CHD8

1.13e-03108884GO:0034708
GeneOntologyCellularComponentvesicle membrane

RAB12 WASH3P ARHGAP32 SNX4 MCTP1 SEC24C COPA KIF1A MAP6 TICAM1 DBH ULK1 FER1L5 CNGB1

1.23e-0313258814GO:0012506
GeneOntologyCellularComponentGolgi-associated vesicle

RAB12 COPA MAP6 CNGB1

1.38e-03114884GO:0005798
GeneOntologyCellularComponentnuclear body

SLC2A4RG SETD1B RAPH1 MTOR CHD5 APBB1 RREB1 SRCAP THAP1 CREBBP POLR3G

1.41e-039038811GO:0016604
GeneOntologyCellularComponenttransport vesicle

RAB12 MCTP1 SEC24C COPA KIF1A MAP6 DBH FER1L5

1.55e-03519888GO:0030133
GeneOntologyCellularComponentautophagosome

RAB12 WASH3P TICAM1 ULK1

1.61e-03119884GO:0005776
GeneOntologyCellularComponentfilopodium

WASH3P RAPH1 APBB1 DAG1

1.82e-03123884GO:0030175
DomainDUF3776

PHF20 PHF20L1

2.19e-052882PF12618
DomainDUF3776

PHF20 PHF20L1

2.19e-052882IPR022255
DomainZF_PHD_1

KMT2D PHF20 PHF20L1 ASXL3 CHD5

9.03e-0596885PS01359
DomainZF_C3H1

ZC3H12A ZC3H4 ZC3H3 ZC3H6

1.61e-0458884PS50103
DomainGUANYLATE_KINASE_2

MAGI2 TJP1 MPP4

1.67e-0423883PS50052
DomainGUANYLATE_KINASE_1

MAGI2 TJP1 MPP4

1.67e-0423883PS00856
DomainGuanylate_kin

MAGI2 TJP1 MPP4

2.43e-0426883PF00625
DomainGK/Ca_channel_bsu

MAGI2 TJP1 MPP4

2.43e-0426883IPR008145
DomainGuanylate_kin-like_dom

MAGI2 TJP1 MPP4

2.43e-0426883IPR008144
DomainGuKc

MAGI2 TJP1 MPP4

2.43e-0426883SM00072
DomainSNF2_N

CHD5 CHD8 SRCAP

4.54e-0432883IPR000330
DomainSNF2_N

CHD5 CHD8 SRCAP

4.54e-0432883PF00176
DomainDNA/RNA_helicase_DEAH_CS

DHX37 CHD5 CHD8

5.93e-0435883IPR002464
DomainDEAH_ATP_HELICASE

DHX37 CHD5 CHD8

7.57e-0438883PS00690
Domain-

ZC3H4 ZC3H3 ZC3H6

8.80e-04408834.10.1000.10
DomainZF_PHD_2

KMT2D PHF20 ASXL3 CHD5

1.06e-0395884PS50016
DomainZnF_C3H1

ZC3H4 ZC3H3 ZC3H6

1.50e-0348883SM00356
Domainzf-CCCH

ZC3H4 ZC3H3 ZC3H6

1.59e-0349883PF00642
DomainHelicase_C

DHX37 CHD5 CHD8 SRCAP

1.64e-03107884PF00271
DomainHELICc

DHX37 CHD5 CHD8 SRCAP

1.64e-03107884SM00490
DomainHelicase_C

DHX37 CHD5 CHD8 SRCAP

1.70e-03108884IPR001650
DomainHELICASE_CTER

DHX37 CHD5 CHD8 SRCAP

1.76e-03109884PS51194
DomainHELICASE_ATP_BIND_1

DHX37 CHD5 CHD8 SRCAP

1.76e-03109884PS51192
DomainDEXDc

DHX37 CHD5 CHD8 SRCAP

1.76e-03109884SM00487
DomainHelicase_ATP-bd

DHX37 CHD5 CHD8 SRCAP

1.82e-03110884IPR014001
DomainNPIP

NPIPB15 NPIPB9

1.93e-0314882IPR009443
DomainP-loop_NTPase

RAB12 MAGI2 KIF1A TJP1 MPP4 DHX37 CHD5 GNL2 SMG9 CHD8 SRCAP

2.08e-038488811IPR027417
DomainPost-SET_dom

KMT2D SETD1B

2.52e-0316882IPR003616
DomainPostSET

KMT2D SETD1B

2.52e-0316882SM00508
DomainGuanylate_kinase_CS

MAGI2 MPP4

2.52e-0316882IPR020590
DomainPOST_SET

KMT2D SETD1B

2.52e-0316882PS50868
DomainZnf_CCCH

ZC3H4 ZC3H3 ZC3H6

2.59e-0358883IPR000571
DomainSH3

ARHGAP32 EFS TJP1 MPP4 ASAP1

3.56e-03216885SM00326
DomainSH3

ARHGAP32 EFS TJP1 MPP4 ASAP1

3.56e-03216885PS50002
DomainZinc_finger_PHD-type_CS

PHF20 PHF20L1 CHD5

3.58e-0365883IPR019786
DomainSH3_domain

ARHGAP32 EFS TJP1 MPP4 ASAP1

3.85e-03220885IPR001452
PathwayREACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES

KMT2D SETD1B PHF20 PHF20L1

1.96e-0538604MM17073
PathwayWP_NEUROINFLAMMATION

MTOR FOS NOS2

2.03e-0513603M39895
PathwayREACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES

KMT2D SETD1B PHF20 PHF20L1

2.94e-0542604M48018
Pubmed

Interaction network of human early embryonic transcription factors.

TRERF1 BCL9L TNRC18 KMT2D ATXN1 ASXL3 ZNF516 CHD8 RREB1 CREBBP IMMT MED12

2.11e-10351941238297188
Pubmed

Human transcription factor protein interaction networks.

TRERF1 BCL9L ARHGAP32 KMT2D COPA VEZF1 ATXN1 DHX37 FOS CHD5 ZNF516 NACA GNL2 CHD8 EIF3G RREB1 SRCAP CREBBP IMMT

7.78e-091429941935140242
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

TRERF1 ELOA EPS15L1 KMT2D SEC24C COPA RAPH1 ZC3H4 ZNF516 PHACTR4 EIF3G ZNF579 SNAPC4 RREB1

2.19e-08774941415302935
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

LPIN3 EPS15L1 TNRC18 KMT2D SLC2A4RG SETD1B ZNF827 MTOR CHD5 ZNF516 CHD8 ULK1 ZNF579 SNAPC4 SRCAP MED12

4.35e-081105941635748872
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

TRERF1 BCL9L TNRC18 KMT2D ATXN1 ZC3H4 CHD8 CREBBP MED12

5.03e-0826894933640491
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

ZSWIM8 SEC24C COPA KIF1A TJP1 MTOR DHX37 GNL2 CHD8 IMMT MED12

1.58e-06653941122586326
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ZSWIM8 MCTP1 ATXN1 ZNF827 ZC3H4 CHD5 GNL2 CHD8 ABHD8 ZNF579 RREB1 SRCAP ZC3H3 CREBBP

1.81e-061116941431753913
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

EPS15L1 KMT2D RAPH1 TJP1 PHACTR4 APBB1 CHD8 SRCAP CREBBP MED12

2.44e-06549941038280479
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

ELOA PHF20L1 VEZF1 DHX37 CHD5 GNL2 CHD8 SNAPC4 RREB1 SRCAP

6.00e-06608941036089195
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

ELOA SEC24C COPA VEZF1 MAP6 TJP1 ZC3H4 DHX37 GNL2 SRCAP ZC3H6 TNXB MED12

6.97e-061082941338697112
Pubmed

Pivotal role of c-Fos in nitric oxide synthase 2 expression in airway epithelial cells.

FOS NOS2

7.23e-06294219135542
Pubmed

siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy.

MTOR ULK1

7.23e-06294217595159
Pubmed

Knockout of ASAP1 induces autophagy in papillary thyroid carcinoma by inhibiting the mTOR signaling pathway.

MTOR ASAP1

7.23e-06294232307199
Pubmed

Mutations in SRCAP, encoding SNF2-related CREBBP activator protein, cause Floating-Harbor syndrome.

SRCAP CREBBP

7.23e-06294222265015
Pubmed

A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome.

KMT2D CREBBP

7.23e-06294227999180
Pubmed

Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism.

ZC3H12A MTOR

7.23e-06294230297433
Pubmed

mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines.

MTOR FOS

7.23e-06294226122641
Pubmed

mTOR Regulates Mineralocorticoid Receptor Transcriptional Activity by ULK1-Dependent and -Independent Mechanisms.

MTOR ULK1

7.23e-06294238325289
Pubmed

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.

MED25 CREBBP MED12

1.80e-051994316799563
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

TRERF1 KMT2D RAPH1 ZNF516 ATF7IP2 CHD8 RREB1 MED12

1.84e-0541894834709266
Pubmed

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.

KMT2D SETD1B ASXL3

2.11e-052094329785026
Pubmed

SETD1B Activates iNOS Expression in Myeloid-Derived Suppressor Cells.

SETD1B NOS2

2.16e-05394228381543
Pubmed

Leveraging the Mendelian disorders of the epigenetic machinery to systematically map functional epigenetic variation.

KMT2D CREBBP

2.16e-05394234463256
Pubmed

STAT-1 and c-Fos interaction in nitric oxide synthase-2 gene activation.

FOS NOS2

2.16e-05394212788789
Pubmed

Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2+/calmodulin-dependent kinase kinase-β (CaMKK-β).

MTOR ULK1

2.16e-05394223027865
Pubmed

Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription.

FOS NACA

2.16e-0539429488446
Pubmed

The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300.

FOS CREBBP

2.16e-05394210487758
Pubmed

AFF4 regulates osteogenic potential of human periodontal ligament stem cells via mTOR-ULK1-autophagy axis.

MTOR ULK1

2.16e-05394237731335
Pubmed

Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells.

MTOR TICAM1

2.16e-05394218924132
Pubmed

ETV4 and AP1 Transcription Factors Form Multivalent Interactions with three Sites on the MED25 Activator-Interacting Domain.

FOS MED25

2.16e-05394228728983
Pubmed

Interaction between STK33 and autophagy promoted renal cell carcinoma metastasis by regulating mTOR/ULK1 signaling pathway.

MTOR ULK1

2.16e-05394237101009
Pubmed

Mediator modulates Gli3-dependent Sonic hedgehog signaling.

CREBBP MED12

2.16e-05394217000779
Pubmed

mTORC1 restricts hepatitis C virus RNA replication through ULK1-mediated suppression of miR-122 and facilitates post-replication events.

MTOR ULK1

2.16e-05394231821132
Pubmed

Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein.

SRCAP CREBBP

2.16e-05394210347196
Pubmed

Ataxin-1 regulates the cerebellar bioenergetics proteome through the GSK3β-mTOR pathway which is altered in Spinocerebellar ataxia type 1 (SCA1).

ATXN1 MTOR

2.16e-05394227466200
Pubmed

KMT2D acetylation by CREBBP reveals a cooperative functional interaction at enhancers in normal and malignant germinal center B cells.

KMT2D CREBBP

2.16e-05394236893259
Pubmed

A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression.

TRERF1 CREBBP

2.16e-05394211349124
Pubmed

Norepinephrine and ß₁-adrenergic signaling facilitate activation of hippocampal CA1 pyramidal neurons during contextual memory retrieval.

FOS DBH

2.16e-05394221377513
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

TRERF1 ARHGAP32 TNRC18 AP5B1 CHD5 ATF7IP2 WNK4 ASAP1

2.25e-0543094835044719
Pubmed

Composite co-activator ARC mediates chromatin-directed transcriptional activation.

MED25 CREBBP MED12

3.26e-052394310235267
Pubmed

cDNAs with long CAG trinucleotide repeats from human brain.

TNRC18 KMT2D MED12

3.26e-05239439225980
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

BCL9L TNRC18 COPA ZC3H4 CHD8 EIF3G CREBBP

3.41e-0533294737433992
Pubmed

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.

SETD1B WDR97 MED25 SMG9 ULK1 SRCAP CREBBP MED12

3.47e-0545794832968282
Pubmed

Genetic interaction mapping in mammalian cells using CRISPR interference.

KMT2D SETD1B SRCAP MED12

3.78e-056994428481362
Pubmed

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy.

MTOR ULK1

4.32e-05494219258318
Pubmed

Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy.

MTOR ULK1

4.32e-05494225980607
Pubmed

Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription.

SRCAP CREBBP

4.32e-05494211581372
Pubmed

Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism.

TICAM1 NOS2

4.32e-05494219644121
Pubmed

CCR5-Dependent Activation of mTORC1 Regulates Translation of Inducible NO Synthase and COX-2 during Encephalomyocarditis Virus Infection.

MTOR NOS2

4.32e-05494226408666
Pubmed

Onset of aquaporin-4 expression in the developing mouse brain.

TJP1 DAG1

4.32e-05494224915007
Pubmed

TOR-mediated Ypt1 phosphorylation regulates autophagy initiation complex assembly.

MTOR ULK1

4.32e-05494237635626
Pubmed

BNIP3 is degraded by ULK1-dependent autophagy via MTORC1 and AMPK.

MTOR ULK1

4.32e-05494223291726
Pubmed

MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.

KMT2D CREBBP

4.32e-05494228398509
Pubmed

Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy.

RAB12 ULK1

4.32e-05494225925668
Pubmed

Involvement of Ras and AP-1 in Helicobacter pylori-induced expression of COX-2 and iNOS in gastric epithelial AGS cells.

FOS NOS2

4.32e-05494219495976
Pubmed

The tight junction protein TJP1 regulates the feeding-modulated hepatic circadian clock.

TJP1 MTOR

4.32e-05494232001717
Pubmed

Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1.

APBB1 ELMO1

4.32e-05494229615491
Pubmed

ARF6-Rac1 signaling-mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1.

APBB1 ELMO1

4.32e-05494233047393
Pubmed

mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex.

MTOR ULK1

4.32e-05494219690328
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TRERF1 MAGI2 ARHGAP32 EPS15L1 SEC24C MAP6 TJP1 ZC3H4 MTOR ZNF516 CHD8

5.90e-05963941128671696
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

TRERF1 PHF20 PHF20L1 VEZF1 ATXN1 FOS ZNF516 SNAPC4 SRCAP ZC3H6

6.76e-05808941020412781
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

KMT2D SETD1B CHD8 SRCAP CREBBP

6.98e-0515794530186101
Pubmed

Autophagy Genes for Wet Age-Related Macular Degeneration in a Finnish Case-Control Study.

MTOR ULK1

7.19e-05594233172148
Pubmed

Ultrasound induces hypoxia-inducible factor-1 activation and inducible nitric-oxide synthase expression through the integrin/integrin-linked kinase/Akt/mammalian target of rapamycin pathway in osteoblasts.

MTOR NOS2

7.19e-05594217588951
Pubmed

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.

MTOR ULK1

7.19e-05594219211835
Pubmed

Fasting-activated ventrolateral medulla neurons regulate T cell homing and suppress autoimmune disease in mice.

FOS DBH

7.19e-05594238182836
Pubmed

PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development.

MTOR ULK1

7.19e-05594227545895
Pubmed

Inhibition of viral pathogenesis and promotion of the septic shock response to bacterial infection by IRF-3 are regulated by the acetylation and phosphorylation of its coactivators.

TICAM1 CREBBP

7.19e-05594223532979
Pubmed

Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth.

MTOR ULK1

7.19e-05594226593251
Pubmed

Characterization of the murine orthologue of a novel human subtelomeric multigene family.

WASH3P WASH4P

7.19e-05594211701968
Pubmed

Manganese is a physiologically relevant TORC1 activator in yeast and mammals.

MTOR ULK1

7.19e-05594235904415
Pubmed

LANP mediates neuritic pathology in Spinocerebellar ataxia type 1.

ATXN1 CREBBP

7.19e-05594222884877
Pubmed

Digitoxin Suppresses Human Cytomegalovirus Replication via Na+, K+/ATPase α1 Subunit-Dependent AMP-Activated Protein Kinase and Autophagy Activation.

MTOR ULK1

7.19e-05594229321306
Pubmed

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

KMT2D PHF20 CHD8

8.14e-053194315960975
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

TNRC18 KMT2D VEZF1 ZNF516 RREB1 CREBBP IMMT

1.06e-0439894735016035
Pubmed

Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels.

TICAM1 NOS2

1.08e-04694229234000
Pubmed

Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF.

FOS CREBBP

1.08e-04694217226766
Pubmed

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery.

MTOR ULK1

1.08e-04694219225151
Pubmed

Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation.

FOS CREBBP

1.08e-04694210497212
Pubmed

Human subtelomeric WASH genes encode a new subclass of the WASP family.

WASH3P WASH4P

1.08e-04694218159949
Pubmed

p300 Modulates the BRCA1 inhibition of estrogen receptor activity.

FOS CREBBP

1.08e-04694211782371
Pubmed

CHARGE and Kabuki syndromes: a phenotypic and molecular link.

KMT2D CHD8

1.08e-04694224705355
Pubmed

Annexin A2 Regulates Autophagy in Pseudomonas aeruginosa Infection through the Akt1-mTOR-ULK1/2 Signaling Pathway.

MTOR ULK1

1.08e-04694226371245
Pubmed

Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment.

KMT2D CREBBP

1.08e-04694238570506
Pubmed

Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.

BCL9L CHD8 CREBBP

1.08e-043494330894540
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

LPIN3 ARHGAP32 RAPH1 ATXN1 TJP1 MTOR PHACTR4 APBB1 WNK4 ITPKB

1.14e-04861941036931259
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

LPIN3 ZSWIM8 EPS15L1 ZC3H12A SEC24C COPA RAPH1 TJP1 MTOR TICAM1 MED12

1.14e-041038941126673895
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

ELOA ARHGAP32 SNX4 KMT2D COPA RAPH1 TJP1 GNL2 PPM1J PTPRT ASAP1

1.26e-041049941127880917
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

RAB12 ARHGAP32 EPS15L1 SEC24C COPA PHACTR4 EIF3G IMMT MED12

1.30e-0470894939231216
Pubmed

Signaling events leading to peroxiredoxin 5 up-regulation in immunostimulated macrophages.

TICAM1 NOS2

1.50e-04794219540914
Pubmed

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.

MTOR ULK1

1.50e-04794221258367
Pubmed

Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.

MAP6 CHD5 ZNF579

1.51e-043894333283408
Pubmed

Network organization of the human autophagy system.

COPA TJP1 MTOR ULK1 SNAPC4 IMMT RUBCN

1.89e-0443794720562859
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

TRERF1 TNRC18 KMT2D VEZF1 ZNF516 CHD8 QRICH1 RREB1 CREBBP MED12 ELMO1

1.94e-041103941134189442
Pubmed

Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation.

FOS CREBBP

2.00e-04894216055710
Pubmed

Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation.

FOS NOS2

2.00e-04894222474389
Pubmed

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.

MTOR ULK1

2.00e-04894223524951
Pubmed

Examining the specificity of Src homology 3 domain--ligand interactions with alkaline phosphatase fusion proteins.

EFS ASAP1

2.00e-0489429126384
Pubmed

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

KMT2D SETD1B

2.00e-04894222266653
Pubmed

Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatocytes during sepsis limits inflammation through cGMP signaling.

TICAM1 NOS2

2.00e-04894225628461
InteractionGSC interactions

BCL9L TNRC18 KMT2D ATXN1 ASXL3 ZNF516 RREB1 CREBBP

6.02e-0987928int:GSC
InteractionHIVEP1 interactions

ELOA SNX4 VEZF1 ATXN1 FOS QRICH1 CREBBP IMMT

2.18e-06186928int:HIVEP1
InteractionCRX interactions

TRERF1 BCL9L TNRC18 KMT2D ATXN1 QRICH1 RREB1 CREBBP MED12

2.43e-06254929int:CRX
InteractionHCFC1 interactions

KMT2D SETD1B PHF20 PHF20L1 ATXN1 ASXL3 MED25 CHD8 THAP1

7.76e-06293929int:HCFC1
InteractionAR interactions

TRERF1 BCL9L TNRC18 KMT2D KIF1A ATXN1 TJP1 ZC3H4 AP5B1 FES CHD8 SH2D2A RREB1 SRCAP CREBBP MED12

9.79e-069929216int:AR
InteractionEGR2 interactions

TRERF1 BCL9L TNRC18 KMT2D ATXN1 RREB1 CREBBP

1.34e-05171927int:EGR2
InteractionSETD1B interactions

KMT2D SETD1B PHF20 PHF20L1 ZC3H3

2.38e-0575925int:SETD1B
InteractionKMT2C interactions

KMT2D SETD1B PHF20 PHF20L1 FOS ASXL3

3.45e-05134926int:KMT2C
InteractionH3-3A interactions

ELOA KMT2D SETD1B PHF20L1 VEZF1 DHX37 CHD5 GNL2 CHD8 SNAPC4 RREB1 SRCAP CREBBP

3.47e-057499213int:H3-3A
GeneFamilyZinc fingers CCCH-type

ZC3H12A ZC3H4 ZC3H3 ZC3H6

6.88e-063564473
GeneFamilyAtaxins|Trinucleotide repeat containing

TNRC18 KMT2D MED12

9.20e-0525643775
GeneFamilyCalcium voltage-gated channel subunits|Membrane associated guanylate kinases

MAGI2 TJP1 MPP4

1.04e-0426643904
GeneFamilyPHD finger proteins

KMT2D PHF20 PHF20L1 CHD5

2.90e-049064488
GeneFamilyWiskott-Aldrich Syndrome protein family

WASH3P WASH4P

1.43e-031664214
GeneFamilyAutophagy related

SNX4 ULK1

6.07e-03336421022
GeneFamilyCyclins|Mediator complex

MED25 MED12

6.07e-03336421061
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT2D SETD1B

6.43e-0334642487
GeneFamilyTudor domain containing

PHF20 PHF20L1

7.59e-0337642780
CoexpressionTHAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_28DY_DN

RAB12 WASH3P ZC3H12A NPIPB15 SEC24C ZNF827 TICAM1 PHACTR4 MED25 FES QRICH1 ULK1 ZC3H3 CREBBP

3.65e-069059314M40865
CoexpressionGSE40655_FOXO1_KO_VS_WT_NTREG_UP

KMT2D SEC24C PHF20L1 VEZF1 ABHD8 PNPLA7 SNAPC4

7.38e-06200937M9439
CoexpressionGSE26669_CTRL_VS_COSTIM_BLOCK_MLR_CD8_TCELL_DN

KMT2D VEZF1 QRICH1 SRCAP CREBBP SLC4A3 MED12

7.38e-06200937M4667
CoexpressionTHAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_7DY_DN

RAB12 ZC3H12A NPIPB15 SETD1B ZNF827 PHACTR4 MED25 QRICH1 ULK1 ZC3H3 CREBBP

1.54e-056349311M40866
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6|World / Primary Cells by Cluster

MAGI2 ZNF385D MAP6 CHD5 NACA PTPRT

4.09e-061999461b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal|World / Primary Cells by Cluster

MAGI2 ZNF385D MAP6 CHD5 NACA PTPRT

4.09e-061999464bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SFTPB TYMP CNGB1 NOS2

1.24e-05679442c95f09e680d2c5e6edfefa5b933617db5786c60
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)--|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SFTPB TYMP CNGB1 NOS2

1.24e-0567944859716ced14c35703c23a538a87621e48eb03aca
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SFTPB TYMP CNGB1 NOS2

1.24e-05679443876baae8344902d517bdff99a920a657a29a150
DiseaseBladder Neoplasm

KMT2D MTOR TYMP CREBBP ASAP1

6.75e-05140895C0005695
DiseaseMalignant neoplasm of urinary bladder

KMT2D MTOR TYMP CREBBP ASAP1

6.98e-05141895C0005684
DiseaseMalignant Cystosarcoma Phyllodes

KMT2D MED12

8.94e-055892C0600066
DiseasePhyllodes Tumor

KMT2D MED12

8.94e-055892C0010701
DiseaseOvarian Mucinous Adenocarcinoma

MTOR ULK1 WNK4

1.12e-0431893C1335167
DiseaseSquamous cell carcinoma of esophagus

KMT2D TYMP CREBBP TNXB

2.00e-0495894C0279626
Diseasenitric oxide exhalation measurement

SMG9 NOS2 PTPRT

2.07e-0438893EFO_0005536
Disease22q11 partial monosomy syndrome

SEC24C RREB1

3.19e-049892C3266101
Diseaseuveitis

SELENOV TNRC18

3.19e-049892EFO_1001231
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

KMT2D FES PTPRT

3.43e-0445893DOID:3748 (is_implicated_in)
DiseaseAsymmetric crying face association

SEC24C RREB1

3.98e-0410892C0431406
Disease22q11 Deletion Syndrome

SEC24C RREB1

3.98e-0410892C2936346
Diseasemultiple sclerosis

LPIN3 EPS15L1 SLC2A4RG MCTP1 ATXN1 RREB1 ELMO1 ASAP1

4.35e-04594898MONDO_0005301
Diseasemeningitis

RAPH1 ITPKB

4.86e-0411892MONDO_0021108
Diseaseairway wall thickness measurement

MAGI2 ZNF385D

5.82e-0412892EFO_0006898
Diseasegallbladder carcinoma (is_marker_for)

TJP1 TYMP

5.82e-0412892DOID:4948 (is_marker_for)
DiseaseX-12707 measurement

NPIPB9 DBH

5.82e-0412892EFO_0800720
Diseasebronchopulmonary dysplasia (is_implicated_in)

SFTPB DAG1

6.87e-0413892DOID:11650 (is_implicated_in)
DiseaseMajor Depressive Disorder

SEC24C RAPH1 MTOR DBH MED12

8.60e-04243895C1269683
DiseaseLymphoma, Follicular, Grade 2

KMT2D CREBBP

9.21e-0415892C1956132
DiseaseLymphoma, Follicular, Grade 3

KMT2D CREBBP

9.21e-0415892C1956131
DiseaseLymphoma, Follicular, Grade 1

KMT2D CREBBP

9.21e-0415892C1956130
DiseaseLymphoma, Large-Cell, Follicular

KMT2D CREBBP

9.21e-0415892C0079745
DiseaseLymphoma, Small Cleaved-Cell, Follicular

KMT2D CREBBP

9.21e-0415892C0079765
DiseaseLymphoma, Mixed-Cell, Follicular

KMT2D CREBBP

9.21e-0415892C0079758
DiseaseJT interval

ZNF385D NACA ZNF579 CREBBP SLC4A3

9.42e-04248895EFO_0007885
DiseaseDiGeorge Syndrome

SEC24C RREB1

1.05e-0316892C0012236
DiseaseCONOTRUNCAL ANOMALY FACE SYNDROME

SEC24C RREB1

1.05e-0316892C0795907
DiseaseT-Cell Lymphoma

KMT2D ASXL3

1.05e-0316892C0079772
DiseaseShprintzen syndrome

SEC24C RREB1

1.05e-0316892C0220704
DiseaseUnipolar Depression

SEC24C RAPH1 MTOR DBH MED12

1.14e-03259895C0041696
DiseaseQT interval

ZNF385D PHF20L1 SH2D2A ZNF579 CREBBP SLC4A3 ELMO1

1.17e-03534897EFO_0004682
Diseaseiritis

SELENOV TNRC18

1.19e-0317892EFO_1000997
Diseasepsoriasis

RAB12 ELOA AP5B1 NOS2 ELMO1

1.44e-03273895EFO_0000676
DiseaseLymphoma, Follicular

KMT2D CREBBP

1.65e-0320892C0024301
Diseasecervical squamous cell carcinoma (is_marker_for)

FOS TYMP

2.00e-0322892DOID:3744 (is_marker_for)
Diseasetriacylglycerol 58:9 measurement

TNXB PTPRT

2.00e-0322892EFO_0010443
Diseaselung squamous cell carcinoma (is_implicated_in)

KMT2D SFTPB

2.38e-0324892DOID:3907 (is_implicated_in)
DiseaseReperfusion Injury

FOS TICAM1 NOS2

2.50e-0389893C0035126
Diseaseinterstitial lung disease (is_marker_for)

SFTPB NOS2

2.58e-0325892DOID:3082 (is_marker_for)
DiseaseHypertensive disease

MTOR FOS NOS2 WNK4

2.66e-03190894C0020538
Diseasesubcutaneous adipose tissue measurement

ATXN1 ATF7IP2 ITPKB

2.83e-0393893EFO_0004766
DiseaseNeurodevelopmental Disorders

ZC3H4 ASXL3 SRCAP

2.83e-0393893C1535926
DiseaseRetinal Diseases

ATXN1 NOS2

3.01e-0327892C0035309
Diseaselissencephaly (implicated_via_orthology)

DAG1 NOS2

3.01e-0327892DOID:0050453 (implicated_via_orthology)
DiseaseSezary Syndrome

KMT2D CREBBP

3.01e-0327892C0036920

Protein segments in the cluster

PeptideGeneStartEntry
EPSKPLAPRILPNPL

ZNF385D

326

Q9H6B1
KLLRSQIPPDVPPPL

C2orf16

1096

Q68DN1
EKEPVPSALPPSLIP

EPS15L1

196

Q9UBC2
PQVRVPLEEPPLSPD

SLC4A3

16

P48751
PLPLRPDAPVEKSPE

CHD8

1996

Q9HCK8
ELLPGAPLPPPKEVI

EIF3G

46

O75821
LENIQIPDAPPPIPK

ELMO1

701

Q92556
SLPPPKPLEGIPERE

CHD5

496

Q8TDI0
PVINTLPPIVDPDPL

CREBBP

1641

Q92793
LSPEPLPQEEEKLPP

APBB1

346

O00213
EDEPPLTLPKPSLIP

ATXN1

786

P54253
ELPLVPDKLNEPTAP

ASXL3

1561

Q9C0F0
LLWEPEPSPKALPEP

ABHD8

416

Q96I13
ILSLQPEPEIPPELP

RAB12

221

Q6IQ22
ALPPPPPELLSDQQK

RAPH1

1201

Q70E73
PQPSPELLLPNSLKP

QRICH1

461

Q2TAL8
DKPTPPDELLPQAIE

NOS2

131

P35228
ESELSLPEKLRPEPP

LPIN3

171

Q9BQK8
PSPVPLPPDLLLKVE

KIAA0100

861

Q14667
KPPNAEPLVAPQLLP

GNL2

461

Q13823
CLEQLLEPPPPPAEP

MCTP1

206

Q6DN14
PKPPAEPAPLLLNVT

MAGI2

186

Q86UL8
PIVPVPLKDQDPLVP

MAP6

751

Q96JE9
PEPLKTQGPRDPQLP

MAP6

776

Q96JE9
LPLLNDPEPKPSVEP

FOS

241

P01100
PLILQEEKAPLPPPE

DAG1

816

Q14118
PLLPPLPDNIPESEE

MPP4

136

Q96JB8
LLLFPPQQLKPPPEL

IMMT

666

Q16891
PQQLKPPPELCPEDI

IMMT

671

Q16891
PPAPTLLEPEKKAPE

MED12

1751

Q93074
EKAAPPALLEPLQPP

MED25

196

Q71SY5
PLPVLKLQPEALEPI

AP5B1

676

Q2VPB7
PLPPSVDDNLKTPPL

NPIPB7

336

O75200
VDDALPLPLPVPQPK

ARHGAP32

1451

A7KAX9
PLPPSVDDNLKTPPL

NPIPB15

331

A6NHN6
AESVPENVPKPPLLP

PHACTR4

156

Q8IZ21
PALQPKEPPPSLLEA

PNPLA7

106

Q6ZV29
KEPPTPIAPPELLAV

PTPRT

286

O14522
LLRQPEKEPAPLPPS

BRME1

81

Q0VDD7
KVPDVLPVLPDLPLP

ELOA

501

Q14241
VDLKEPPPPSAPSLL

LINC02908

111

Q6ZV77
PDIDPNAKLLQPPAP

COPA

786

P53621
QLLKPNIPEPELPSD

DBH

196

P09172
LDQAPKVPPTPEPLP

BCL9L

276

Q86UU0
QLAELPQKPPPGDLP

ASAP1

926

Q9ULH1
PLTPKPPAELEPDLE

EFS

191

O43281
LPEPPAPLPELVDKT

ATF7IP2

556

Q5U623
SKGPPEPPPVQLELE

DHX37

21

Q8IY37
DAPQKLLPIPDSLPI

RUBCN

656

Q92622
LPPKRLDPDAIPSPI

SEC24C

316

P53992
PLPPSVDDNLKTPPL

NPIPB9

351

F8W1W9
PLPPDLLPPEAAKDR

KIF1A

761

Q12756
ELEPPDPLARLPQLK

PHF20L1

981

A8MW92
ELEPPEPLARLPQLK

PHF20

976

Q9BVI0
PPIVKLFDAPEAPLP

MTOR

1116

P42345
LPPPLQLIPEVQKPL

FES

441

P07332
PDPERQLQPAPLEPL

SNX4

6

O95219
PKPLRDPLPDPLLDK

SFTPB

161

P07988
EKEPSQLLRPKPPIP

SH2D2A

236

Q9NP31
PENPEAPKPPLQFLV

FER1L5

1461

A0AVI2
ALPSPELLPQDPDKP

ITPKB

541

P27987
PEAGQEPLPKLLPQP

PRORY

46

Q9H606
LKDLVEILQDPSPPP

PPM1J

181

Q5JR12
AAPPAPAPLEKPIVL

SMG9

86

Q9H0W8
ELLKQPGPQEPLPPT

SHISA8

181

B8ZZ34
PPPVEPTKLPFKELD

SETD1B

1596

Q9UPS6
LPLLPEEDPEPAPSL

SELENOV

161

P59797
EEPPQVLEIKPPPSA

SRCAP

371

Q6ZRS2
PTPIPLQPKEEPKEA

CNGB1

216

Q14028
ELPPLESPLPLPAAE

TNRC18

1171

O15417
PLPPREPPSKAAQEL

ZNF516

996

Q92618
PQLIADPEPKPRKPA

ZC3H3

351

Q8IXZ2
KPDPVSSINLPLPPL

ZC3H6

891

P61129
PKAPNLEPPLPEEEK

ZC3H12A

116

Q5D1E8
EPPDQKPLLPIPITQ

VEZF1

36

Q14119
LELPELLEPPALPSP

SLC2A4RG

276

Q9NR83
LLLPKPPVTEELPPL

RREB1

1051

Q92766
PQSLPLPILEPVKNP

TICAM1

311

Q8IUC6
KLPLPRVEPQPFPLD

WDR97

1576

A6NE52
PEDLILSPRPKASPP

SPATA31D1

181

Q6ZQQ2
KVDLQDGVLTPPPPP

WASH4P

306

A8MWX3
PTPEPPIKPRLEELT

TNXB

2296

P22105
EDLLEPQEQLPPPPL

THAP1

91

Q9NVV9
APDLPPVPEEKQLPP

TMEM52B

156

Q4KMG9
KVDLQDGVLTPPPPP

WASH3P

291

C4AMC7
KLPDVVLKPPPLFPD

POLR3G

26

O15318
PEDLIPLPIPKQDAV

ZC3H4

981

Q9UPT8
PPPQSLELLLLPVPK

ZNF827

341

Q17R98
IPEPQKPQLKPPEDI

TJP1

1326

Q07157
LANPPDLKVEPPPAK

ZSWIM8

801

A7E2V4
KLSEPPLQLQPTPPL

nan

251

A8MUI8
ALDLEKPPLPQPGPE

SNAPC4

1251

Q5SXM2
PLPLANIKEEPPSPG

ZNF579

501

Q8NAF0
LPDPSPEPKQLPELI

TYMP

26

P19971
KARELEALPPEPGPP

WNK4

526

Q96J92
PKLPDFLQRNPLPPI

ULK1

606

O75385
EEGEKVLPPQPQPPL

TRERF1

546

Q96PN7
LSPELEKPPLSPRPE

KMT2D

851

O14686
LRIPVSPPLPDPEDL

NACA

501

E9PAV3