Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN2A SCN3A

8.90e-0714283GO:0031402
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN1A SCN2A SCN3A

6.28e-0626283GO:0005248
GeneOntologyMolecularFunctionalkali metal ion binding

SCN1A SCN2A SCN3A

6.28e-0626283GO:0031420
GeneOntologyMolecularFunctionsodium channel activity

SCN1A SCN2A SCN3A

5.21e-0552283GO:0005272
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC38A1 SCN1A SCN2A SCN3A

9.05e-05171284GO:0015081
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

SCN1A SCN2A

2.55e-0417282GO:0099508
GeneOntologyMolecularFunctionDNA secondary structure binding

CLSPN FANCM

1.50e-0341282GO:0000217
GeneOntologyBiologicalProcessmembrane depolarization during action potential

SCN1A SCN2A SCN3A

1.73e-0536293GO:0086010
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

SCN1A SCN2A SCN3A

8.94e-0562293GO:0086002
GeneOntologyBiologicalProcessneuronal action potential

SCN1A SCN2A SCN3A

9.38e-0563293GO:0019228
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SLC38A1 SCN1A SCN2A SCN3A

1.96e-04208294GO:0035725
GeneOntologyBiologicalProcesscardiac muscle cell action potential

SCN1A SCN2A SCN3A

2.45e-0487293GO:0086001
GeneOntologyBiologicalProcesscardiac muscle cell contraction

SCN1A SCN2A SCN3A

2.98e-0493293GO:0086003
GeneOntologyBiologicalProcesstransmission of nerve impulse

SCN1A SCN2A SCN3A

5.14e-04112293GO:0019226
GeneOntologyBiologicalProcesssodium ion transport

SLC38A1 SCN1A SCN2A SCN3A

5.65e-04275294GO:0006814
GeneOntologyBiologicalProcessmembrane depolarization

SCN1A SCN2A SCN3A

6.44e-04121293GO:0051899
GeneOntologyBiologicalProcessactin-mediated cell contraction

SCN1A SCN2A SCN3A

7.41e-04127293GO:0070252
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN1A SCN2A SCN3A

1.45e-0617283GO:0001518
GeneOntologyCellularComponentsodium channel complex

SCN1A SCN2A SCN3A

7.68e-0629283GO:0034706
GeneOntologyCellularComponentnode of Ranvier

SCN1A SCN2A

3.24e-0420282GO:0033268
GeneOntologyCellularComponentaxon initial segment

SCN1A SCN2A

6.87e-0429282GO:0043194
HumanPhenoFocal emotional seizure with laughing

PACS1 SCN1A SCN2A

2.56e-061793HP:0010821
HumanPhenoFocal emotional seizure

PACS1 SCN1A SCN2A

3.07e-061893HP:0025613
HumanPhenoSimple febrile seizure

SCN1A SCN2A SCN3A

1.09e-052793HP:0011171
HumanPhenoFocal non-motor seizure

PACS1 SCN1A SCN2A

3.65e-054093HP:0032679
HumanPhenoPhotosensitive myoclonic seizure

SCN1A SCN2A

7.73e-05892HP:0001327
HumanPhenoCyanotic episode

SCN1A SCN2A

7.73e-05892HP:0200048
HumanPhenoArachnoid cyst

CPLANE1 SCN1A SCN2A

1.12e-045893HP:0100702
HumanPhenoAbnormal arachnoid mater morphology

CPLANE1 SCN1A SCN2A

1.18e-045993HP:0100700
HumanPhenoLimited neck range of motion

SCN1A SCN2A

1.51e-041192HP:0000466
HumanPhenoEpilepsia partialis continua

SCN1A SCN2A

1.81e-041292HP:0012847
HumanPhenoFocal automatism seizure

SCN1A SCN2A

1.81e-041292HP:0032898
HumanPhenoGeneralized cerebral atrophy/hypoplasia

SCN1A SCN2A

2.14e-041392HP:0007058
HumanPhenoAortopulmonary collateral arteries

SCN1A SCN2A

2.88e-041592HP:0031834
HumanPhenoPhotosensitive tonic-clonic seizure

SCN1A SCN2A

2.88e-041592HP:0007207
HumanPhenoFacial tics

SCN1A SCN2A

2.88e-041592HP:0011468
HumanPhenoClonic seizure

SCN1A SCN2A SCN3A

3.04e-048193HP:0020221
HumanPhenoDysgenesis of the hippocampus

SCN1A SCN2A

3.29e-041692HP:0025101
HumanPhenoComplex febrile seizure

SCN1A SCN2A

3.29e-041692HP:0011172
HumanPhenoAbnormal morphology of bones of the lower limbs

ZNF407 FANCM CPLANE1 SCN1A SCN2A

3.63e-0442295HP:0040066
HumanPhenoDelayed ability to stand

ZNF407 SCN2A

3.72e-041792HP:0025335
HumanPhenoAtypical absence status epilepticus

SCN1A SCN2A

3.72e-041792HP:0011151
HumanPhenoFocal motor status epilepticus

SCN1A SCN2A

3.72e-041792HP:0032663
HumanPhenoVisually-induced seizure

SCN1A SCN2A

4.18e-041892HP:0020216
HumanPhenoGeneralized non-convulsive status epilepticus without coma

SCN1A SCN2A

4.18e-041892HP:0032860
HumanPhenoNon-convulsive status epilepticus without coma

SCN1A SCN2A

5.19e-042092HP:0032671
HumanPhenoTalipes valgus

SCN1A SCN2A

5.73e-042192HP:0004684
HumanPhenoReflex seizure

SCN1A SCN2A

6.29e-042292HP:0020207
HumanPhenoTibial torsion

SCN1A SCN2A

6.89e-042392HP:0100694
HumanPhenoAbnormal tibia morphology

CPLANE1 SCN1A SCN2A

6.90e-0410793HP:0002992
HumanPhenoFocal hemiclonic seizure

SCN1A SCN2A

8.15e-042592HP:0006813
HumanPhenoEpileptic encephalopathy

SCN1A SCN2A SCN3A

9.42e-0411993HP:0200134
HumanPhenoLimited knee extension

SCN1A SCN2A

9.52e-042792HP:0003066
HumanPhenoStatus epilepticus without prominent motor symptoms

SCN1A SCN2A

9.52e-042792HP:0031475
HumanPhenoFocal aware seizure

SCN1A SCN2A

1.02e-032892HP:0002349
HumanPhenoStatus epilepticus with prominent motor symptoms

SCN1A SCN2A

1.10e-032992HP:0032658
HumanPhenoFocal impaired awareness seizure

SCN1A SCN2A SCN3A

1.11e-0312693HP:0002384
HumanPhenoProgressive gait ataxia

SCN1A SCN2A

1.18e-033092HP:0007240
HumanPhenoProgressive ataxia

SCN1A SCN2A

1.18e-033092HP:0001329
HumanPhenoFocal motor seizure

PACS1 SCN1A SCN2A

1.25e-0313193HP:0011153
HumanPhenoCogwheel rigidity

SCN1A SCN2A

1.34e-033292HP:0002396
HumanPhenoObsessive-compulsive trait

SCN1A SCN2A

1.42e-033392HP:0008770
HumanPhenoGeneralized clonic seizure

SCN1A SCN2A

1.51e-033492HP:0011169
HumanPhenoCalcaneovalgus deformity

SCN1A SCN2A

1.51e-033492HP:0001848
HumanPhenoAbnormal meningeal morphology

CD19 CPLANE1 SCN1A SCN2A

1.57e-0332494HP:0010651
HumanPhenoDeformed tarsal bones

SCN1A SCN2A

1.60e-033592HP:0008119
HumanPhenoLimitation of knee mobility

SCN1A SCN2A

1.60e-033592HP:0010501
HumanPhenoInfection-related seizure

SCN1A SCN2A SCN3A

1.67e-0314593HP:0032892
HumanPhenoSeizure precipitated by febrile infection

SCN1A SCN2A SCN3A

1.67e-0314593HP:0032894
HumanPhenoFebrile seizure (within the age range of 3 months to 6 years)

SCN1A SCN2A SCN3A

1.67e-0314593HP:0002373
HumanPhenoLimitation of neck motion

SCN1A SCN2A

1.69e-033692HP:0005986
HumanPhenoDisturbance of facial expression

SCN1A SCN2A

1.69e-033692HP:0005324
HumanPhenoAbnormal neck physiology

SCN1A SCN2A

1.69e-033692HP:0025669
HumanPhenoImpulsivity

SCN1A SCN2A SCN3A

1.81e-0314993HP:0100710
HumanPhenoFocal-onset seizure

PACS1 SCN1A SCN2A SCN3A

2.00e-0334694HP:0007359
HumanPhenoHyperkinetic movements

SCN1A SCN2A

2.09e-034092HP:0002487
HumanPhenoFocal clonic seizure

SCN1A SCN2A

2.30e-034292HP:0002266
HumanPhenoAbnormality of the tubular bones

PACS1 ZNF407 FANCM CPLANE1 SCN2A

2.37e-0363295HP:0100713
HumanPhenoAbnormality of the long tubular bones

PACS1 ZNF407 FANCM CPLANE1 SCN2A

2.37e-0363295HP:0100714
HumanPhenoPes planus

PACS1 FANCM SCN1A SCN2A

2.45e-0336594HP:0001763
MousePhenoenhanced liver regeneration

CLSPN BAZ2B

1.99e-054262MP:0005516
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A

6.02e-086283PF11933
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A

6.02e-086283IPR024583
DomainNa_channel_asu

SCN1A SCN2A SCN3A

3.60e-0710283IPR001696
DomainNa_trans_assoc

SCN1A SCN2A SCN3A

3.60e-0710283IPR010526
DomainNa_trans_assoc

SCN1A SCN2A SCN3A

3.60e-0710283PF06512
DomainChannel_four-helix_dom

SCN1A SCN2A SCN3A

8.36e-0557283IPR027359
Domain-

SCN1A SCN2A SCN3A

8.36e-05572831.20.120.350
DomainMethyl_CpG_DNA-bd

SETDB1 BAZ2B

1.18e-0411282IPR001739
DomainMBD

SETDB1 BAZ2B

1.18e-0411282PF01429
DomainMBD

SETDB1 BAZ2B

1.18e-0411282SM00391
DomainMBD

SETDB1 BAZ2B

1.18e-0411282PS50982
DomainDNA-bd_dom

SETDB1 BAZ2B

1.18e-0411282IPR016177
DomainIQ

SCN1A SCN2A SCN3A

2.38e-0481283SM00015
DomainIQ_motif_EF-hand-BS

SCN1A SCN2A SCN3A

3.25e-0490283IPR000048
DomainIQ

SCN1A SCN2A SCN3A

3.58e-0493283PS50096
DomainZF_PHD_1

PHF20L1 TRIM24 BAZ2B

3.93e-0496283PS01359
DomainTUDOR

SETDB1 PHF20L1

5.38e-0423282PS50304
DomainIon_trans_dom

SCN1A SCN2A SCN3A

6.49e-04114283IPR005821
DomainIon_trans

SCN1A SCN2A SCN3A

6.49e-04114283PF00520
DomainBromodomain_CS

TRIM24 BAZ2B

6.89e-0426282IPR018359
DomainTUDOR

SETDB1 PHF20L1

7.43e-0427282SM00333
DomainTudor

SETDB1 PHF20L1

9.19e-0430282IPR002999
DomainZnf_FYVE_PHD

PHF20L1 TRIM24 BAZ2B

1.35e-03147283IPR011011
DomainBROMODOMAIN_1

TRIM24 BAZ2B

1.40e-0337282PS00633
DomainBromodomain

TRIM24 BAZ2B

1.47e-0338282PF00439
DomainBROMODOMAIN_2

TRIM24 BAZ2B

1.71e-0341282PS50014
DomainBROMO

TRIM24 BAZ2B

1.80e-0342282SM00297
DomainBromodomain

TRIM24 BAZ2B

1.80e-0342282IPR001487
Domain-

TRIM24 BAZ2B

1.80e-03422821.20.920.10
DomainZinc_finger_PHD-type_CS

PHF20L1 TRIM24

4.25e-0365282IPR019786
DomainIQ

SCN1A SCN3A

5.05e-0371282PF00612
DomainDEAD

FANCM DDX42

5.33e-0373282PF00270
DomainDEAD/DEAH_box_helicase_dom

FANCM DDX42

5.33e-0373282IPR011545
DomainPHD

TRIM24 BAZ2B

5.62e-0375282PF00628
DomainZnf_PHD-finger

TRIM24 BAZ2B

6.22e-0379282IPR019787
DomainARM-like

CUL9 RELCH PPP6R2

7.49e-03270283IPR011989
DomainPHD

TRIM24 BAZ2B

7.83e-0389282SM00249
DomainZnf_PHD

TRIM24 BAZ2B

8.17e-0391282IPR001965
DomainZF_PHD_2

TRIM24 BAZ2B

8.88e-0395282PS50016
DomainHelicase_C

FANCM DDX42

1.12e-02107282PF00271
PathwayWP_DRAVET_SYNDROME

SCN1A SCN2A SCN3A

7.82e-0628203M45519
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN1A SCN2A SCN3A

1.07e-0531203M877
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN1A SCN2A SCN3A

1.18e-0532203M27455
PathwayREACTOME_L1CAM_INTERACTIONS

SCN1A SCN2A SCN3A

6.32e-04121203M872
PathwayREACTOME_CARDIAC_CONDUCTION

SCN1A SCN2A SCN3A

7.79e-04130203M27454
Pubmed

Sodium channels SCN1A, SCN2A and SCN3A in familial autism.

SCN1A SCN2A SCN3A

5.21e-10329312610651
Pubmed

SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.

SCN1A SCN2A SCN3A

5.21e-10329323859570
Pubmed

Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.

SCN1A SCN2A SCN3A

5.21e-10329314973256
Pubmed

Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.

SCN1A SCN2A SCN3A

5.21e-10329318784617
Pubmed

Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.

SCN1A SCN2A SCN3A

5.21e-10329317544618
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN1A SCN2A SCN3A

2.08e-09429317537961
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN1A SCN2A SCN3A

2.08e-09429335031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN1A SCN2A SCN3A

2.08e-09429329578003
Pubmed

Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.

SCN1A SCN2A SCN3A

2.08e-09429335801810
Pubmed

Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.

SCN1A SCN2A SCN3A

2.08e-0942938974318
Pubmed

Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.

SCN1A SCN2A SCN3A

5.21e-0952931679748
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN1A SCN2A SCN3A

5.21e-0952938812438
Pubmed

Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.

SCN1A SCN2A SCN3A

5.21e-09529324337656
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN1A SCN2A SCN3A

1.04e-08629323652591
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN1A SCN2A SCN3A

4.36e-08929315746173
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN1A SCN2A SCN3A

4.36e-08929316382098
Pubmed

Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.

SCN1A SCN2A SCN3A

1.14e-07122938169823
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN1A SCN2A SCN3A

1.14e-071229330175250
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN1A SCN2A SCN3A

1.48e-071329315123669
Pubmed

Confirmation of quantitative trait loci for alcohol preference in mice.

SCN1A SCN2A SCN3A

2.36e-07152939726281
Pubmed

Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.

SCN1A SCN2A

6.71e-07229229649454
Pubmed

Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.

SCN2A SCN3A

6.71e-07229220346423
Pubmed

Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.

SCN1A SCN2A

6.71e-07229226311622
Pubmed

Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.

SCN1A SCN2A

6.71e-07229210827969
Pubmed

Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.

SCN1A SCN2A

6.71e-07229215249644
Pubmed

Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.

SCN1A SCN3A

6.71e-07229227690330
Pubmed

Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.

SCN1A SCN2A

6.71e-07229219694741
Pubmed

Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.

SCN2A SCN3A

6.71e-07229211245985
Pubmed

The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.

SCN1A SCN2A

6.71e-07229221377452
Pubmed

Differential expression of two sodium channel subtypes in human brain.

SCN1A SCN2A

6.71e-0722921317301
Pubmed

Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.

SCN1A SCN3A

6.71e-07229223965409
Pubmed

Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.

SCN2A SCN3A

6.71e-07229223016767
Pubmed

Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.

SCN2A SCN3A

6.71e-07229227153334
Pubmed

Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.

SCN1A SCN2A

6.71e-07229233096315
Pubmed

Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.

SCN1A SCN3A

6.71e-07229224990319
Pubmed

Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.

SCN1A SCN2A

6.71e-07229231439038
Pubmed

SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.

SCN1A SCN2A

6.71e-07229230693367
Pubmed

Voltage-gated sodium channels in taste bud cells.

SCN2A SCN3A

2.01e-06329219284629
Pubmed

Gene-to-gene interaction between sodium channel-related genes in determining the risk of antiepileptic drug resistance.

SCN1A SCN2A

2.01e-06329219270815
Pubmed

Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.

SCN1A SCN2A

2.01e-06329228784306
Pubmed

Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells.

SCN2A SCN3A

2.01e-06329216052353
Pubmed

Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.

SCN1A SCN2A

2.01e-06329232185219
Pubmed

Clinical exome sequencing as the first-tier test for diagnosing developmental disorders covering both CNV and SNV: a Chinese cohort.

SCN1A SCN2A

2.01e-06329232005694
Pubmed

Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy.

SCN1A SCN2A

2.01e-06329225155934
Pubmed

Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).

SCN1A SCN3A

2.01e-06329233895391
Pubmed

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

SCN1A SCN2A

2.01e-06329217928448
Pubmed

Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

SCN1A SCN2A

2.01e-06329232845893
Pubmed

Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.

SCN1A SCN2A

2.01e-06329228518218
Pubmed

GAPDH-mediated posttranscriptional regulations of sodium channel Scn1a and Scn3a genes under seizure and ketogenic diet conditions.

SCN1A SCN3A

2.01e-06329227816501
Pubmed

Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms.

SCN1A SCN2A

4.02e-06429226637798
Pubmed

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

SCN1A SCN2A

4.02e-06429221156207
Pubmed

Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis.

CLSPN FANCM

4.02e-06429219270156
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN2A SCN3A

6.70e-06529217724025
Pubmed

140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.

PACS1 STRN3 RELCH PHF20L1

1.01e-0516329416512683
Pubmed

Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.

SCN1A SCN2A

1.41e-05729225818041
Pubmed

Report and abstracts of the Fourth International Workshop on Human Chromosome 2 Mapping 1996.

SCN1A SCN2A SCN3A

2.87e-05712938751373
Pubmed

Common variants associated with general and MMR vaccine-related febrile seizures.

SCN1A SCN2A

3.01e-051029225344690
Pubmed

Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment.

SCN1A SCN2A

3.01e-051029220602612
Pubmed

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PHF20L1 TRIM24 BAZ2B

3.38e-057529325593309
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

SENP6 TRIM24 BAZ2B ZBTB21

3.39e-0522229437071664
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

NUCKS1 SENP6 PACS1 STRN3 INTS3 ZBTB21

3.66e-0577429615302935
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

CUL9 KIF27 PHF20L1 INTS3 TRIM24 ZBTB21

6.43e-0585729625609649
Pubmed

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

RELCH BAZ2B BAHCC1

8.72e-0510329310819331
Pubmed

Screening E3 substrates using a live phage display library.

NUCKS1 DDX42

9.06e-051729224124579
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

NUCKS1 SENP6 STRN3 PPP6R2 DDX42 ZBTB21

1.03e-0493429633916271
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

SENP6 CUL9 SETDB1 CLSPN PPP6R2

1.15e-0458829538580884
Pubmed

USP7 Regulates Cytokinesis through FBXO38 and KIF20B.

CLSPN TRIM24 ZBTB21

1.24e-0411629330804394
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

SENP6 PHF20L1 TRIM24 BAZ2B ZBTB21

1.35e-0460829536089195
Pubmed

Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.

SETDB1 TRIM24 ZBTB21

1.55e-0412529332891193
Pubmed

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.

CLSPN FANCM

1.68e-042329222017875
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

CUL9 SETDB1 BAHCC1

1.74e-0413029312421765
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

CUL9 SETDB1 CLSPN TRIM24 BAHCC1 ZBTB21

2.72e-04111629631753913
Pubmed

Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.

RELCH CLSPN PPP6R2

3.62e-0416729325659891
Pubmed

Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC.

NUCKS1 SETDB1

4.16e-043629216097034
Pubmed

Proximity Mapping of CCP6 Reveals Its Association with Centrosome Organization and Cilium Assembly.

STRN3 CLSPN

4.63e-043829236674791
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

SENP6 TRIM24 DDX42 ZBTB21

4.83e-0444429434795231
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ZNF407 FANCM PPP6R2 BAZ2B

7.15e-0449329415368895
Pubmed

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.

CUL9 STRN3 PPP6R2

7.26e-0421229333853758
InteractionCBX3 interactions

NUCKS1 SENP6 SETDB1 CLSPN TRIM24 DDX42 ZBTB21

2.84e-05646297int:CBX3
InteractionMAGEA10 interactions

CUL9 TRIM24 DDX42

5.02e-0550293int:MAGEA10
InteractionSCN4B interactions

SCN1A SCN2A

5.57e-058292int:SCN4B
CytobandEnsembl 112 genes in cytogenetic band chr2q24

BAZ2B SCN1A SCN2A SCN3A

1.26e-06127294chr2q24
Cytoband2q24.3

SCN1A SCN2A

4.60e-05162922q24.3
GeneFamilySodium voltage-gated channel alpha subunits

SCN1A SCN2A SCN3A

1.31e-0792231203
GeneFamilyZinc fingers CXXC-type|Methyl-CpG binding domain containing

SETDB1 BAZ2B

7.72e-05112221025
GeneFamilyPHD finger proteins

PHF20L1 TRIM24 BAZ2B

1.72e-049022388
GeneFamilyTudor domain containing

SETDB1 PHF20L1

9.17e-0437222780
CoexpressionGSE29618_PRE_VS_DAY7_POST_LAIV_FLU_VACCINE_PDC_DN

SLC38A1 SENP6 INTS3 SCN3A

6.47e-05198294M5001
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

ZNF407 PHF20L1 CPLANE1 TRIM24 FAM13B BAZ2B

6.98e-05656296M18979
CoexpressionNAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP

SENP6 PACS1 SETDB1 FAM13B BAZ2B

7.01e-05399295M41172
ToppCellCOVID-19-B_cells-Activated_B_cells|COVID-19 / group, cell type (main and fine annotations)

SLC38A1 CD19 MYT1 SCN3A

5.09e-06177294653bb62a3744d4024ab3186ee01d410ed62832a6
ToppCellPCW_13-14-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SCN1A MYT1 SCN2A SCN3A

5.32e-06179294af0b54c9ea0b6e4210f22dbb6e88ecd3276a5f86
ToppCellsevere-B_cell|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

FANCM CD19 SCN2A SCN3A

7.32e-061942942fee6083fb56b16d1f04fd0b92ec622fd26ba3fa
ToppCellsevere-B_cell|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

FANCM CD19 SCN2A SCN3A

7.47e-061952940fc3c605609c9e6bdea15d73c45def2188ae5fb1
ToppCellmyeloid-pro-pDC|myeloid / Lineage and Cell class

SLC38A1 NUCKS1 CLSPN BAHCC1

7.62e-0619629470daf4fabb68aecc5cc9f03d6f6495dd29b74a16
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

SCN1A MYT1 SCN2A SCN3A

8.25e-062002944fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

SCN1A MYT1 SCN2A SCN3A

8.25e-06200294f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

SCN1A MYT1 SCN2A SCN3A

8.25e-06200294cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

SCN1A MYT1 SCN2A SCN3A

8.25e-06200294310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

SCN1A MYT1 SCN2A SCN3A

8.25e-06200294c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

SCN1A MYT1 SCN2A SCN3A

8.25e-06200294961858738ce35db8760c8c2e136f8369bc444ccf
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CD19 CPLANE1 SCN3A

8.34e-05131293a3a086ce6e69707ca6a042f3b15c130f81909acb
ToppCellsevere-Lymphocytic-B_cells_2|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

CD19 SCN2A SCN3A

9.32e-0513629356a7b5c2e098b4a49124d1b905257a52eb38b519
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CD19 PPP6R2 SCN3A

1.02e-04140293af9efcbaeeae69fcdac4a15fa244728b65915564
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 CUL9 SCN2A

1.08e-04143293990844ca674d30b2924c74b45bed4fdfb8463fa7
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 BAZ2B SCN2A

1.13e-04145293fd02d55755c35288a42ab08a82450b370aad35a7
ToppCell3'_v3-Lung-Lymphocytic_T_CD4-Tnaive/CM_CD4_activated|Lung / Manually curated celltypes from each tissue

FANCM INTS3 BAZ2B

1.27e-041512939bfb807e1180b31fa9a2c500ce993de9707c070f
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SCN1A SCN2A SCN3A

1.37e-0415529377fdae85d36efb776db977eb424b32487ef222e4
ToppCell3'_v3-bone_marrow-Lymphocytic_B-Pro-B|bone_marrow / Manually curated celltypes from each tissue

CD19 SCN3A BAHCC1

1.40e-04156293b093dbba6662e4fffc8aa577587b77f64ac44b56
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MYT1 SCN2A SCN3A

1.48e-041592937747cef94c55144fddcd024a7495318357f1351b
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NUCKS1 CLSPN CD19

1.62e-04164293249d8f75a64bce7db52ce0c563f496b9edf602a6
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

1.62e-041642936fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCellPND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLC38A1 CLSPN CD19

1.65e-0416529366f0364098d82629aa2ec1dfe0c5ad23de7c2c12
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SLC38A1 CD19 SCN3A

1.65e-04165293fead3f2032f8fa5f7f0159a4434989b3d65debbb
ToppCell10x5'-Liver-Hematopoietic_progenitors|Liver / Manually curated celltypes from each tissue

CLSPN FANCM BAHCC1

1.68e-04166293ae967570248cf86ca3ddf55e33bcbb3e4e3684bc
ToppCell10x5'-Liver-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|Liver / Manually curated celltypes from each tissue

CLSPN FANCM BAHCC1

1.68e-04166293a176e87aa6eec81d1fb79a028f759182d11b567d
ToppCell3'_v3-GI_small-bowel-Lymphocytic_B|GI_small-bowel / Manually curated celltypes from each tissue

CD19 MYT1 SCN3A

1.74e-041682935535c1b8b7fde7b59a1bc0580cebdfa963aa1c39
ToppCell3'_v3-GI_small-bowel-Lymphocytic_B-Memory_B_cells|GI_small-bowel / Manually curated celltypes from each tissue

CD19 MYT1 SCN3A

1.74e-041682938e025bb0541746e232b77ac0e31412ae71420c47
ToppCell356C-Myeloid-Dendritic-cDC_proliferating_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CLSPN FANCM PPP6R2

1.83e-04171293b113fbebb89056af0b9c775d2fb6552206a80467
ToppCellE12.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CUL9 ZNF407 PPP6R2

1.86e-041722933b9be685fcd1634498a603b692f5ac6ddd0de176
ToppCellBAL-Control-Lymphocyte-B|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SLC38A1 CD19 SCN3A

2.00e-041762937c1ecec45b5fe5e73cbce0fadca726ffd10c0316
ToppCellCOVID-19-lung-B_cells|lung / Disease (COVID-19 only), tissue and cell type

SLC38A1 CD19 SCN3A

2.03e-04177293f54691e5558091c1734ab15153a10bff15ed171e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.03e-04177293f35b04c3557ebbdeba37dec54c8f45880eafb422
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_2|356C / Donor, Lineage, Cell class and subclass (all cells)

PACS1 CCDC82 ZBTB21

2.06e-041782938b939659f713eea50a1a6e28b571f680ca0b4c12
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_4|343B / Donor, Lineage, Cell class and subclass (all cells)

CUL9 CLSPN FANCM

2.10e-04179293c09c3eed43d1aa3b7aa8f3021e6f2737840cde16
ToppCellCTRL-Lymphoid-B_cell|CTRL / Disease state, Lineage and Cell class

SLC38A1 CD19 SCN3A

2.10e-04179293dd4055c0a8360ea10323ef6249519a6ae08fc05a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CLSPN SCN2A SCN3A

2.13e-04180293401df9cddcbca1eb8f0d2687bcacd98e95dc1493
ToppCellIPF-Lymphoid-B|World / Disease state, Lineage and Cell class

SLC38A1 PACS1 CD19

2.13e-0418029330f9398c9b784f49470847a025bac90687e997a1
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC38A1 SCN1A SCN2A

2.13e-04180293f6a2208960d0df1500c974cc44c3c054cd7475a9
ToppCellFetal_29-31_weeks-Immune-B_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SLC38A1 CD19 SCN3A

2.17e-0418129357f20341c3e9f9f6ed5b6c181605ad35bae91414
ToppCellPCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_B-im_B_cell_(15)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SLC38A1 CD19 SCN3A

2.17e-0418129351e4d6bfdbf414d8e30aee2e6f7492f4f7f54373
ToppCellnucseq-Immune-Lymphocytic_B-Lymphocytic_B-B|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SLC38A1 PACS1 CD19

2.17e-041812938d8cc4dae2c8bd5f4b1c159f2a52edc4c9449c86
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.24e-04183293b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.24e-04183293d340ab5a77e8d819a1dfb4ca3e9a4b9bc988923c
ToppCellCTRL-Lymphoid|CTRL / Disease state, Lineage and Cell class

SLC38A1 CD19 SCN3A

2.27e-0418429326fb2c4e6cb9950c27eb15428e7e74e5abb4397d
ToppCellPCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MYT1 SCN2A SCN3A

2.27e-04184293571136c832cb8c08457744152231537aa8e8abd7
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.27e-041842939690d4290e70f9bda889754ffb30b0af1f7cb94b
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NUCKS1 CLSPN CD19

2.27e-041842938f40093de5bb978f046d66e8f05f333686a009a4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.31e-041852933d73b3e0bceb192257e5cfbe64b7ccb379b6e22d
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC38A1 SCN1A SCN2A

2.31e-0418529370de48988c1f8e0809afc8092b663aa439d8e528
ToppCellPCW_13-14-Immune_Lymphocytic-Immune_Lymphocytic_B-im_B_cell_(15)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SLC38A1 CD19 SCN3A

2.31e-041852938fc357ee041bfd588986730a52ea2021b5f88941
ToppCellfacs-Kidney-nan-18m-Lymphocytic|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC38A1 CD19 DDX42

2.31e-04185293a3b937163346d729115e6335336e33d3e71fccb0
ToppCell10x5'-GI_small-bowel-Lymphocytic_B|GI_small-bowel / Manually curated celltypes from each tissue

CD19 MYT1 SCN3A

2.35e-04186293a5c0bd4f6a7542f67d478dcdc0645ae6d927a395
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.35e-04186293d65fa6d8e8a195ea10cfde1499d096d6acf7a634
ToppCellmoderate-Lymphoid-B_cell|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SLC38A1 CD19 SCN3A

2.35e-04186293fd2c4c3e8929ca5d64f6c5064e5f3d3d6ba07b5f
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CUL9 CLSPN FANCM

2.35e-04186293bca5215d406f1785bf3a420201d5686071fcaca5
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.35e-0418629308632045d499e61dd96ff29a5a9a208afe58dc58
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.35e-04186293b3358e0fa6d845c81e94d56c8575f016621d28ff
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MYT1 SCN2A SCN3A

2.35e-04186293b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCellPCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_B|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SLC38A1 CD19 SCN3A

2.38e-041872939d298f43ae81d72091b31aaa6df41046d4aa31c5
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.38e-041872932d17408b3b5f09d135084fd7ccce98e6b5ca632b
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC38A1 SCN1A SCN2A

2.38e-041872937b2cd0c618ed081223343f3bec2244c8723c9a31
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.38e-04187293e3095455d2f255854f339f6b05fa87852af0700f
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SLC38A1 CD19 SCN3A

2.42e-04188293d8decd9b5967873ca8320c2f9f07365f163c777f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.42e-041882934154f4787483c7e076e87a187733a9f666742c3d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.46e-041892933a295c215b5c18e7c673f92b7af5be523421682c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.46e-041892938ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.46e-04189293a9864873b19ab3e60acf11f288fa7275badc2e42
ToppCell10x5'-Liver-Lymphocytic_B|Liver / Manually curated celltypes from each tissue

CD19 MYT1 SCN3A

2.46e-041892931ebff8185060d78f27f8d887e9adaa5f8faf2196
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.46e-04189293532aaf02b364c5c4f58a2021c7c21d86df3875c9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.46e-0418929390aae7e806882bebfad78a78e9a16cf56af3ecd4
ToppCellFetal_29-31_weeks-Immune-B_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SLC38A1 CD19 SCN3A

2.50e-04190293424550418c1bd4eb070cf3c41cf09fa9d89aef37
ToppCellCF-Lymphoid-B_cell|CF / Disease state, Lineage and Cell class

SLC38A1 CD19 SCN3A

2.50e-04190293374d8fd63c733178acab07682ed1519693efab45
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CD19 SCN2A SCN3A

2.50e-04190293a7498fe55b7810c482291db782dc5282675d246a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.50e-041902934836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

SLC38A1 CD19 SCN3A

2.50e-041902930724665ac8238f2383c3a929d89abf4a48ec2420
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.54e-041912933e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCellFetal_29-31_weeks-Immune-B_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SLC38A1 CD19 SCN3A

2.54e-0419129384452125d1b5b76974e3f9126f611eff16d45c25
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.54e-0419129396b78b4e819ea6052334bfcbc7abbf35897df885
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SLC38A1 CD19 SCN3A

2.58e-04192293446c61c0d6ba89c619efe87ee495951299953981
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.58e-041922930bb06738e1c3ec0c044a7ee61f6cf1d4781fb53c
ToppCellControl-B_intermediate-10|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SLC38A1 CD19 MYT1

2.58e-04192293224bd958369ba8fa0d7be2126f7dc61c9f6ac19d
ToppCell11.5-Airway-Epithelial-Epithelial|Airway / Age, Tissue, Lineage and Cell class

MYT1 SCN2A SCN3A

2.58e-04192293a77d3692ff02ef7e066a9bd9e22725055a25c4d4
ToppCellCOVID-19-kidney-CNT|kidney / Disease (COVID-19 only), tissue and cell type

SLC38A1 SCN2A SCN3A

2.58e-04192293d32ae226d95b4b6adb99d14b602be09b661d4cd9
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SLC38A1 SCN1A SCN3A

2.58e-041922931d0d6fb89a2b941b7caab2f1f07d6bd5433a11e7
ToppCell10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SLC38A1 CD19 SCN3A

2.58e-04192293800edadd1d1ba6b7e0a0398030dd4b61c9c480c7
ToppCellCOVID_non-vent-Lymphocytic-B_cell-|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

SLC38A1 CD19 SCN3A

2.62e-0419329391955c3773c9729a96e82f240f06b072367970d9
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like_Prolif-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NUCKS1 CLSPN TRIM24

2.62e-04193293e477f5ddbb9d5878560998250ca0e1a5467953f4
ToppCellCOVID_non-vent-Lymphocytic-B_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

SLC38A1 CD19 SCN3A

2.62e-0419329332d139f922cd19adc1cc1e0e9a828115be9945d6
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.66e-04194293be869e186386d03ebb670971dd24fa656b4b0edf
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.66e-0419429369bff17df4a760ccf081cf52ff04af02c14f448d
ToppCellControl-Lymphoid-Plasma,_B_cells|Control / Condition, Lineage and Cell class

SLC38A1 CD19 SCN3A

2.66e-0419429331fff4361ebed6308b1e6b2b705ee6e0a695bd0c
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.66e-0419429304bfc555743f7d8821439d05ae442d15e9886c59
ToppCellControl-B_cell|Control / Disease group,lineage and cell class （2021.01.30）

SLC38A1 CD19 SCN3A

2.66e-041942938388fe4df3461d85b21bd6847a4d32c030aaece4
ToppCellBAL-Control-Lymphocyte-B|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

SLC38A1 CD19 SCN3A

2.66e-041942931537e2285d0a8d0a4175dd0b8b1d1ccd887229fc
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC38A1 SCN2A SCN3A

2.66e-041942934d6c9b016e3a0641954a8ea10c97d1cd76fadd9f
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SLC38A1 NUCKS1 CD19

2.70e-04195293a4d36654b968acb1aea252ac203683939461f1d1
ToppCellASK452-Endothelial-Lymphatic|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq

SLC38A1 RELCH SCN3A

2.70e-0419529320f492299a684ac1b7dd1bbc36a533cd6f9a1c93
ToppCell356C-Myeloid-Dendritic|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

SLC38A1 NUCKS1 CLSPN

2.70e-04195293ba8b8831bd5f544f4e25f13949d04e164ecdcd12
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SLC38A1 NUCKS1 CD19

2.70e-04195293cd811abd949ef201aef1c8515da5575ab1b1cfea
DrugZonisamide

SCN1A SCN2A SCN3A

1.25e-0617293DB00909
DrugAPETx1, Anthopleura elegantissima

SCN2A SCN3A

2.34e-056292ctd:C475726
Drugfenpropathrin

SCN2A SCN3A

2.34e-056292ctd:C044267
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN1A SCN2A SCN3A

1.02e-0710293DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN1A SCN2A SCN3A

1.02e-0710293DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1A SCN2A SCN3A

1.87e-0712293DOID:0060170 (implicated_via_orthology)
Diseaseanxiety disorder (implicated_via_orthology)

SCN1A SCN2A SCN3A

1.30e-0622293DOID:2030 (implicated_via_orthology)
DiseaseParkinson disease

SLC38A1 NUCKS1 CD19 CCDC82 SCN2A

1.42e-05321295MONDO_0005180
DiseaseSeizure, Febrile, Simple

SCN1A SCN2A

1.95e-057292C0149886
DiseaseSeizure, Febrile, Complex

SCN1A SCN2A

1.95e-057292C0751057
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN1A SCN2A

3.34e-059292C3502809
DiseaseFebrile Convulsions

SCN1A SCN2A

3.34e-059292C0009952
DiseaseInfantile Severe Myoclonic Epilepsy

SCN1A SCN2A

7.23e-0513292C0751122
DiseaseMMR-related febrile seizures

SCN1A SCN2A

9.72e-0515292EFO_0006519
DiseaseEarly infantile epileptic encephalopathy with suppression bursts

SCN1A SCN2A

1.11e-0416292C0393706
DiseaseFebrile seizure (within the age range of 3 months to 6 years)

SCN1A SCN2A

1.41e-0418292HP_0002373
Diseaseserine measurement

PACS1 SCN3A

5.44e-0435292EFO_0009774
Diseaseepilepsy (implicated_via_orthology)

SCN1A SCN2A SCN3A

5.44e-04163293DOID:1826 (implicated_via_orthology)
DiseaseManic Disorder

PACS1 SCN2A

2.22e-0371292C0024713
DiseaseManic

PACS1 SCN2A

2.67e-0378292C0338831
DiseaseDepression, Bipolar

PACS1 SCN2A

2.74e-0379292C0005587
DiseaseEpilepsy, Cryptogenic

SCN1A SCN2A

2.95e-0382292C0086237
DiseaseAwakening Epilepsy

SCN1A SCN2A

2.95e-0382292C0751111
DiseaseAura

SCN1A SCN2A

2.95e-0382292C0236018
DiseaseNeurodevelopmental Disorders

SCN1A SCN2A

3.77e-0393292C1535926

Protein segments in the cluster

PeptideGeneStartEntry
AVEEDFEFDDNSSFS

BAHCC1

1861

Q9P281
LVFDNCETFNEDDSD

BAZ2B

2131

Q9UIF8
NAEAAFSDDEEDLNS

INTS3

531

Q68E01
VDYSQFQESDDADED

NUCKS1

11

Q9H1E3
SITFSDENDDQDFEL

RELCH

276

Q9P260
FFENEEEDFSSNDLS

FAM13B

211

Q9NYF5
NDESENEQDSSLLDF

FANCM

1531

Q8IYD8
EENAYFEDEEEDSSN

DDX42

71

Q86XP3
QFSDNSDDEESEGQE

KIF27

641

Q86VH2
NYSEEEEESFSSEQE

PACS1

276

Q6VY07
DSDESFENDEELDSN

CCDC82

56

Q8N4S0
ENAADFQDFEAEETN

CPLANE1

501

Q9H799
DEDSFSNAESYENED

CD19

451

P15391
DNDSFSYDESENLDQ

CUL9

2486

Q8IWT3
FNDEEFADQDDNINA

PPP6R2

581

O75170
QDFDSTNFEESQDED

PHF20L1

661

A8MW92
TDNVSSAFEQDDFEE

HSCB

196

Q8IWL3
ETFNFLENADDSDED

STRN3

246

Q13033
DFENLNTEEFSSESE

SCN3A

1111

Q9NY46
EDPEESNDDSSDDNF

SETDB1

896

Q15047
SNDDSSDDNFCKDED

SETDB1

901

Q15047
ESDFENLNTEDFSSE

SCN1A

1121

P35498
NDNEFDSDEDEHSDS

CLSPN

1006

Q9HAW4
RNESEDNKFSDDSDD

TRIM24

1016

O15164
VFSDSSEQVNFDSED

ZBTB21

846

Q9ULJ3
NDFADDEHSTFEDND

SCN2A

591

Q99250
ESDFENLNTEEFSSE

SCN2A

1111

Q99250
VDFSEDQDNQDDSSD

SENP6

931

Q9GZR1
ETEEESNFNEDHSFC

ZNF407

1151

Q9C0G0
DDNISNDSNDFTEVE

SLC38A1

21

Q9H2H9
ASSEADDQEVSEENF

MYT1

756

Q01538