Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ORANGE	HEYL HEY1 HEY2 HES4	1.91e-06	9	211	4	SM00511
Domain	Orange_dom	HEYL HEY1 HEY2 HES4	7.30e-06	12	211	4	IPR003650
Domain	Hairy_orange	HEYL HEY1 HEY2 HES4	7.30e-06	12	211	4	PF07527
Domain	ORANGE	HEYL HEY1 HEY2 HES4	1.05e-05	13	211	4	PS51054
Domain	ARM-like	ARMC2 INSC AP5Z1 IFRD2 MMS19 AGBL1 TARBP1 HEATR6 MROH1 PKP3 SERAC1 TNPO3	6.05e-05	270	211	12	IPR011989
Domain	EGF	MATN3 F7 NOTCH3 CELSR3 LRP6 LRP5 AGRN TNXB	9.33e-05	126	211	8	PF00008
Domain	LRP5/6	LRP6 LRP5	1.27e-04	2	211	2	IPR017049
Domain	-	ARMC2 INSC AP5Z1 IFRD2 MMS19 HEATR6 MROH1 PKP3 SERAC1 TNPO3	2.24e-04	222	211	10	1.25.10.10
Domain	Cadherin_CS	PCDHGC5 DSC3 PCDHA8 PCDHA7 PCDHA6 CELSR3 CDH16	2.39e-04	109	211	7	IPR020894
Domain	FN3	SPEG OBSCN SDK2 CSF2RA RIMBP2 TNXB LRIT1 EPHA8 MYBPC3	2.61e-04	185	211	9	SM00060
Domain	CADHERIN_1	PCDHGC5 DSC3 PCDHA8 PCDHA7 PCDHA6 CELSR3 CDH16	2.98e-04	113	211	7	PS00232
Domain	Cadherin	PCDHGC5 DSC3 PCDHA8 PCDHA7 PCDHA6 CELSR3 CDH16	2.98e-04	113	211	7	PF00028
Domain	CADHERIN_2	PCDHGC5 DSC3 PCDHA8 PCDHA7 PCDHA6 CELSR3 CDH16	3.15e-04	114	211	7	PS50268
Domain	-	PCDHGC5 DSC3 PCDHA8 PCDHA7 PCDHA6 CELSR3 CDH16	3.15e-04	114	211	7	2.60.40.60
Domain	CA	PCDHGC5 DSC3 PCDHA8 PCDHA7 PCDHA6 CELSR3 CDH16	3.32e-04	115	211	7	SM00112
Domain	Cadherin-like	PCDHGC5 DSC3 PCDHA8 PCDHA7 PCDHA6 CELSR3 CDH16	3.50e-04	116	211	7	IPR015919
Domain	EGF	MATN3 F7 GPR179 NOTCH3 CELSR3 BRINP2 LRP6 LRP5 AGRN TNXB	3.52e-04	235	211	10	SM00181
Domain	Cadherin	PCDHGC5 DSC3 PCDHA8 PCDHA7 PCDHA6 CELSR3 CDH16	3.89e-04	118	211	7	IPR002126
Domain	Protein_kinase_ATP_BS	CDK12 SPEG OBSCN MAP3K4 JAK2 JAK3 MOS CIT LIMK2 WEE2 PKN1 DCLK1 EPHA8	3.93e-04	379	211	13	IPR017441
Domain	FN3	SPEG OBSCN SDK2 CSF2RA RIMBP2 TNXB LRIT1 EPHA8 MYBPC3	4.47e-04	199	211	9	PS50853
Domain	ARM-type_fold	ARMC2 DOCK5 INSC IFRD2 MMS19 AGBL1 TARBP1 HEATR6 MROH1 PKP3 SERAC1 TNPO3	4.96e-04	339	211	12	IPR016024
Domain	fn3	SPEG OBSCN SDK2 RIMBP2 TNXB LRIT1 EPHA8 MYBPC3	5.19e-04	162	211	8	PF00041
Domain	FN3_dom	SPEG OBSCN SDK2 CSF2RA RIMBP2 TNXB LRIT1 EPHA8 MYBPC3	6.36e-04	209	211	9	IPR003961
Domain	Tyr_kinase_non-rcpt_Jak/Tyk2	JAK2 JAK3	7.51e-04	4	211	2	IPR016251
Domain	Cadherin_tail	PCDHGC5 PCDHA8 PCDHA7 PCDHA6	7.81e-04	37	211	4	PF15974
Domain	Cadherin_CBD	PCDHGC5 PCDHA8 PCDHA7 PCDHA6	7.81e-04	37	211	4	IPR031904
Domain	EGF-like_CS	MATN3 F7 NOTCH3 LAMB3 CELSR3 LRP6 LRP5 AGRN TNXB EPHA8	7.97e-04	261	211	10	IPR013032
Domain	EGF_2	MATN3 F7 NOTCH3 LAMB3 CELSR3 LRP6 LRP5 AGRN TNXB EPHA8	8.95e-04	265	211	10	PS01186
Pathway	REACTOME_NOTCH3_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	WWC1 NOTCH3 HEYL HEY1 HEY2	5.53e-06	25	149	5	M27880
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MYCL MTA2 MAN2B1 CDK12 TMEM94 SPEG OBSCN NCLN AHDC1 PLEKHH3 JAK2 JAK3 PHLDB1 UBN1 IFRD2 WDR90 HERC2 CAMSAP1 DOCK6 SEMA4F SH2B3 SZT2 TRMT1 LAMB3 ADGRL1 CIT DENND1A FBXO46 TFE3 HEYL LLGL2 MROH1 CELSR3 IL17RE NAPRT LRP5 PKN1 AGRN TNPO3 PCNT	1.26e-19	1105	214	40	35748872
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	WDR4 PEPD OBSCN STEAP2 ARMC2 F7 AHDC1 DOCK5 JAK2 PHLDB1 COQ8A DOCK6 NOTCH3 LRRC41 TRMT9B RNF213 ADGRL1 GRIK2 DENND1A PKP3 LRP5 ZFHX3 PKN1 RIMS1 HPS5 ZRANB1 VPS13B PCNT	1.61e-07	1489	214	28	28611215
Pubmed	Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis.	HEYL HEY1 HEY2	2.30e-07	3	214	3	10415358
Pubmed	Hesr, a mediator of the Notch signaling, functions in heart and vessel development.	HEYL HEY1 HEY2	2.30e-07	3	214	3	16165016
Pubmed	HES and HERP families: multiple effectors of the Notch signaling pathway.	HEYL HEY1 HEY2	2.30e-07	3	214	3	12548545
Pubmed	Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer.	HEYL HEY1 HEY2 HES4	4.45e-07	11	214	4	17611704
Pubmed	Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats.	HEYL HEY1 HEY2	9.15e-07	4	214	3	21290414
Pubmed	Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family.	HEYL HEY1 HEY2	9.15e-07	4	214	3	10860664
Pubmed	Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism.	HEYL HEY1 HEY2	9.15e-07	4	214	3	15485867
Pubmed	Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.	NOTCH3 HEYL HEY1 HEY2	1.80e-06	15	214	4	12971992
Pubmed	Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.	NOTCH3 HEYL HEY1 HEY2	1.80e-06	15	214	4	14672936
Pubmed	The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina.	HEYL HEY1 HEY2	2.28e-06	5	214	3	11160397
Pubmed	Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors.	HEYL HEY1 HEY2	2.28e-06	5	214	3	21454491
Pubmed	Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.	HEYL HEY1 HEY2	2.28e-06	5	214	3	11095750
Pubmed	HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments.	HEYL HEY1 HEY2	2.28e-06	5	214	3	10588864
Pubmed	An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.	NOTCH3 HEYL HEY1 HEY2	2.39e-06	16	214	4	17273555
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CTTNBP2 IQGAP1 IQSEC1 HERC2 CAMSAP1 PRRC2A CACNB1 TPPP GRIK2 CCDC6 CIT SHANK3 DZANK1 WASF2 RIMBP2 PKN1 RIMS1 AGRN DCLK1 PCNT	2.46e-06	963	214	20	28671696
Pubmed	Segmental expression of Notch and Hairy genes in nephrogenesis.	NOTCH3 HEYL HEY1 HEY2	3.12e-06	17	214	4	15821257
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	TUBGCP2 NCLN COQ8A PRRC2A TARBP1 RNF213 HEATR6	3.88e-06	104	214	7	31240132
Pubmed	HeyL promotes neuronal differentiation of neural progenitor cells.	HEYL HEY1 HEY2	4.53e-06	6	214	3	21259317
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	IQGAP1 DOCK5 MMS19 HERC2 DOCK6 PRRC2A CIT HEATR6 TOP2B	4.94e-06	202	214	9	33005030
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	TRAPPC5 STXBP4 SPART TUBGCP2 NCLN HERC2 DOCK6 LRRC41 SEMA4F FASTKD1 TRMT1 CIT HEATR6 TIMM29 TNPO3 RBM41 PCNT	4.96e-06	754	214	17	33060197
Pubmed	Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear.	NOTCH3 HEYL HEY1 HEY2	7.68e-06	21	214	4	24583262
Pubmed	Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes.	HEYL HEY1 HEY2	7.90e-06	7	214	3	10964718
Pubmed	Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts.	HEYL HEY1 HEY2	7.90e-06	7	214	3	16199874
Pubmed	The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function.	HEYL HEY1 HEY2	7.90e-06	7	214	3	10924525
Pubmed	Hey bHLH Proteins Interact with a FBXO45 Containing SCF Ubiquitin Ligase Complex and Induce Its Translocation into the Nucleus.	HEYL HEY1 HEY2	7.90e-06	7	214	3	26068074
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TMEM94 SPEG MAP3K4 PHLDB1 GANAB RAB3GAP2 ADGRL1 MROH1 BRINP2 RIMBP2 VPS13B PCNT	9.47e-06	407	214	12	12693553
Pubmed	Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade.	NOTCH3 HEYL HEY1 HEY2	1.13e-05	23	214	4	31789590
Pubmed	Rhox8 homeobox gene ablation leads to rete testis abnormality and male subfertility in mice†.	CFTR AMH SLC9A3 HEY1	1.34e-05	24	214	4	37471646
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	SPEG IQSEC1 PRRC2A CACNB1 TPPP CIT DZANK1 RIMS1 DCLK1	1.45e-05	231	214	9	16452087
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	CAMSAP1 DNAH5 DNHD1 RBM15 SDK2 SF3B3 TNPO3 VPS13B TOP2B	1.61e-05	234	214	9	36243803
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	NOTCH3 HEYL HEY1 HEY2	1.87e-05	26	214	4	34189436
Pubmed	Notch signaling controls liver development by regulating biliary differentiation.	NOTCH3 HEYL HEY1 HEY2	1.87e-05	26	214	4	19369401
Pubmed	The Notch signaling pathway controls the size of the ocular lens by directly suppressing p57Kip2 expression.	NOTCH3 HEY1 HEY2	1.88e-05	9	214	3	17709399
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MTA2 TUBGCP2 ALMS1 COQ8A IQSEC1 MMS19 MTO1 AGBL1 PDLIM2 WWC1 LRRC41 TDRKH QTRT2 RNF213 LIMK2 MTA1 SF3B3 ZFHX3 IRX2 CDH16	2.11e-05	1116	214	20	31753913
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHGC5 PCDHA8 PCDHA7 PCDHA6	2.54e-05	28	214	4	15347688
Pubmed	Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea.	HEYL HEY1 HEY2	2.67e-05	10	214	3	18291358
Pubmed	Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2.	HEYL HEY1 HEY2	2.67e-05	10	214	3	25733872
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CDK12 SPART IQGAP1 COQ8A AP5Z1 WDR90 DOCK6 SDK2 SZT2 NCAPH SF3B3 CELSR3 HPS5	2.75e-05	529	214	13	14621295
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	IQSEC1 CAMSAP1 SDK2 FASTKD1 GRIK2 FAM171B CIT SHANK3	3.25e-05	197	214	8	36604605
Pubmed	Notch signaling regulates ovarian follicle formation and coordinates follicular growth.	NOTCH3 AMH HEYL HEY2	3.37e-05	30	214	4	24552588
Pubmed	HeyL regulates the number of TrkC neurons in dorsal root ganglia.	HEYL HEY1 HEY2	3.65e-05	11	214	3	19631204
Pubmed	Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.	PCDHA8 PCDHA7 PCDHA6	3.65e-05	11	214	3	9655502
Pubmed	Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers.	HEYL HEY1 HEY2	3.65e-05	11	214	3	21989910
Pubmed	Pharyngeal arch artery defects and lethal malformations of the aortic arch and its branches in mice deficient for the Hrt1/Hey1 transcription factor.	NOTCH3 HEY1 HEY2	3.65e-05	11	214	3	26577899
Pubmed	Notch Signaling Target Genes are Directly Correlated to Esophageal Squamous Cell Carcinoma Tumorigenesis.	HEY1 HEY2	3.77e-05	2	214	2	25361534
Pubmed	Cancer gene profiling in non-small cell lung cancers reveals activating mutations in JAK2 and JAK3 with therapeutic implications.	JAK2 JAK3	3.77e-05	2	214	2	29082853
Pubmed	Hypercoagulability evaluation in congenital red blood cell disorders using thrombin generation assay.	NOTCH3 HEYL	3.77e-05	2	214	2	37024320
Pubmed	Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6.	LRP6 LRP5	3.77e-05	2	214	2	21887268
Pubmed	14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells.	JAK2 SH2B3	3.77e-05	2	214	2	22546852
Pubmed	PAR1&2 driven placenta EVT invasion act via LRP5/6 as coreceptors.	LRP6 LRP5	3.77e-05	2	214	2	33136328
Pubmed	Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens.	TRPV1 RIMS1	3.77e-05	2	214	2	21076424
Pubmed	Modifiers of ovarian function in girls and women with classic galactosemia.	GALT AMH	3.77e-05	2	214	2	23690308
Pubmed	Agrin promotes synaptic differentiation by counteracting an inhibitory effect of neurotransmitter.	CHAT AGRN	3.77e-05	2	214	2	16043708
Pubmed	LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.	LRP6 LRP5	3.77e-05	2	214	2	15084453
Pubmed	Reduced NHE3-mediated Na+ absorption increases survival and decreases the incidence of intestinal obstructions in cystic fibrosis mice.	CFTR SLC9A3	3.77e-05	2	214	2	19164484
Pubmed	Synergistic effect of high lactase activity genotype and galactose-1-phosphate uridyl transferase (GALT) mutations on idiopathic presenile cataract formation.	GALT LCT	3.77e-05	2	214	2	18454942
Pubmed	Extracellular mRNA transported to the nucleus exerts translation-independent function.	ZC3H12D ZC3H12A	3.77e-05	2	214	2	34135341
Pubmed	Co-deletion of Lrp5 and Lrp6 in the skeleton severely diminishes bone gain from sclerostin antibody administration.	LRP6 LRP5	3.77e-05	2	214	2	33164872
Pubmed	Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly.	OBSCN MYBPC3	3.77e-05	2	214	2	19403693
Pubmed	LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis.	LRP6 LRP5	3.77e-05	2	214	2	25902418
Pubmed	HERP, a new primary target of Notch regulated by ligand binding.	HEY1 HEY2	3.77e-05	2	214	2	11486044
Pubmed	Phase separation and zinc-induced transition modulate synaptic distribution and association of autism-linked CTTNBP2 and SHANK3.	CTTNBP2 SHANK3	3.77e-05	2	214	2	35562389
Pubmed	Congenital Nystagmus Gene FRMD7 Is Necessary for Establishing a Neuronal Circuit Asymmetry for Direction Selectivity.	FRMD7 CHAT	3.77e-05	2	214	2	26711119
Pubmed	The involvement of the canonical Wnt-signaling receptor LRP5 and LRP6 gene variants with ADHD and sexual dimorphism: Association study and meta-analysis.	LRP6 LRP5	3.77e-05	2	214	2	30474181
Pubmed	Mechanisms of epigenetic and cell-type specific regulation of Hey target genes in ES cells and cardiomyocytes.	HEY1 HEY2	3.77e-05	2	214	2	25446183
Pubmed	In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular Junctions.	LRP6 LRP5	3.77e-05	2	214	2	36552732
Pubmed	Idiopathic Juvenile Osteoporosis: Clinical Experience from a Single Centre and Screening of LRP5 and LRP6 Genes.	LRP6 LRP5	3.77e-05	2	214	2	25783012
Pubmed	Gene targeting approaches in mice: assessing the roles of LRP5 and LRP6 in osteoblasts.	LRP6 LRP5	3.77e-05	2	214	2	19147944
Pubmed	Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6.	LRP6 LRP5	3.77e-05	2	214	2	15537447
Pubmed	LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin.	LRP6 LRP5	3.77e-05	2	214	2	17335347
Pubmed	The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development.	LRP6 LRP5	3.77e-05	2	214	2	19503830
Pubmed	MTA1 promotes viability and motility in nasopharyngeal carcinoma by modulating IQGAP1 expression.	IQGAP1 MTA1	3.77e-05	2	214	2	29125886
Pubmed	LRP5-/6 gene polymorphisms and its association with risk of abnormal bone mass in postmenopausal women.	LRP6 LRP5	3.77e-05	2	214	2	37202775
Pubmed	Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication.	LRP6 LRP5	3.77e-05	2	214	2	20926594
Pubmed	Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men.	LRP6 LRP5	3.77e-05	2	214	2	16355283
Pubmed	Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo.	LRP6 LRP5	3.77e-05	2	214	2	28425175
Pubmed	Evidence against a human cell-specific role for LRP6 in anthrax toxin entry.	LRP6 LRP5	3.77e-05	2	214	2	18350154
Pubmed	Expression level and differential JAK2-V617F-binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms.	JAK2 SH2B3	3.77e-05	2	214	2	20870899
Pubmed	Clinical Phenotype and Relevance of LRP5 and LRP6 Variants in Patients With Early-Onset Osteoporosis (EOOP).	LRP6 LRP5	3.77e-05	2	214	2	33118644
Pubmed	Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases.	SPEG OBSCN	3.77e-05	2	214	2	15185077
Pubmed	Lack of association of LRP5 and LRP6 polymorphisms with type 2 diabetes mellitus in the Japanese population.	LRP6 LRP5	3.77e-05	2	214	2	18493104
Pubmed	SH2B3 (LNK) mutations from myeloproliferative neoplasms patients have mild loss of function against wild type JAK2 and JAK2 V617F.	JAK2 SH2B3	3.77e-05	2	214	2	23590807
Pubmed	Notch3 and HEY-1 as prognostic biomarkers in pancreatic adenocarcinoma.	NOTCH3 HEY1	3.77e-05	2	214	2	23226563
Pubmed	The Polymorphisms in LNK Gene Correlated to the Clinical Type of Myeloproliferative Neoplasms.	JAK2 SH2B3	3.77e-05	2	214	2	27111338
Pubmed	Lrp5 and Lrp6 are required for maintaining self-renewal and differentiation of hematopoietic stem cells.	LRP6 LRP5	3.77e-05	2	214	2	30668923
Pubmed	Overexpression of MTA1 inhibits the metastatic ability of ZR-75-30 cells in vitro by promoting MTA2 degradation.	MTA2 MTA1	3.77e-05	2	214	2	30642362
Pubmed	Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.	LRP6 LRP5	3.77e-05	2	214	2	22433869
Pubmed	Assignment of the metastasis-associated gene (Mta1) to mouse chromosome band 12F and the metastasis-associated gene 2 (Mta2) to mouse chromosome band 19B by fluorescence in situ hybridization.	MTA2 MTA1	3.77e-05	2	214	2	11856890
Pubmed	Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast.	LRP6 LRP5	3.77e-05	2	214	2	25802278
Pubmed	Intron-less processed Pcdhalpha genes in the central nervous system.	PCDHA8 PCDHA6	3.77e-05	2	214	2	14697259
Pubmed	The NOTCH3 Downstream Target HEYL Is Required for Efficient Human Airway Basal Cell Differentiation.	NOTCH3 HEYL	3.77e-05	2	214	2	34831437
Pubmed	Loss of SLC9A3 decreases CFTR protein and causes obstructed azoospermia in mice.	CFTR SLC9A3	3.77e-05	2	214	2	28384194
Pubmed	Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina.	LRP6 LRP5	3.77e-05	2	214	2	33545636
Pubmed	Differential regulation of proliferation and differentiation in neural precursor cells by the Jak pathway.	JAK2 JAK3	3.77e-05	2	214	2	20979137
Pubmed	Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density.	LRP6 LRP5	3.77e-05	2	214	2	12579474
Pubmed	The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction.	JAK2 JAK3	3.77e-05	2	214	2	12351625
Pubmed	A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover.	TRPV1 SCGN	3.77e-05	2	214	2	28637794
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	JAK2 NOTCH3 MOS PCDHA8 PCDHA7 PCDHA6 SHANK3 CSF2RA CELSR3 RIMS1	4.10e-05	329	214	10	17474147
Interaction	TOP3B interactions	MYCL MTA2 MAN2B1 CDK12 TMEM94 SPEG OBSCN NCLN AHDC1 PLEKHH3 IQGAP1 JAK2 JAK3 PHLDB1 UBN1 IFRD2 MMS19 WDR90 HERC2 CAMSAP1 DOCK6 PRRC2A SEMA4F TDRKH RBM15 SH2B3 SZT2 TRMT1 LAMB3 ADGRL1 CIT DENND1A FBXO46 TFE3 HEYL LLGL2 MROH1 CELSR3 IL17RE NAPRT LRP5 PKN1 AGRN DCAF4 TNPO3 PCNT	8.03e-12	1470	208	46	int:TOP3B
Cytoband	Ensembl 112 genes in cytogenetic band chr17q25	TMEM94 ACOX1 EVPL SDK2 RNF213 LLGL2 MRPL38 PPP1R27	1.17e-04	307	217	8	chr17q25
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	MAN2B1 TRAPPC5 NCLN GDF1 JAK3 GRIN3B DOCK6 NOTCH3 AMH TRMT1 ADGRL1 PKN1 TIMM29	1.22e-04	797	217	13	chr19p13
GeneFamily	Basic helix-loop-helix proteins	MYCL TFE3 HEYL HEY1 HEY2 HES4	2.79e-04	110	147	6	420
GeneFamily	Topoisomerases	TOP1MT TOP2B	9.64e-04	6	147	2	1050
GeneFamily	G protein-coupled receptors, Class C orphans	GPR179 GPRC5A	1.34e-03	7	147	2	285
GeneFamily	Clustered protocadherins	PCDHGC5 PCDHA8 PCDHA7 PCDHA6	1.83e-03	64	147	4	20
GeneFamily	Fibronectin type III domain containing	OBSCN SDK2 TNXB LRIT1 EPHA8 MYBPC3	1.98e-03	160	147	6	555
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	SPEG OBSCN SDK2 CEACAM20 LRIT1 MYBPC3	2.05e-03	161	147	6	593
Coexpression	GSE15930_NAIVE_VS_48H_IN_VITRO_STIM_CD8_TCELL_UP	F7 NOTCH3 MOS SEMA4F ADGRL1 USP2 RFLNB CCNB1IP1 AGRN ZRANB1	5.24e-06	198	212	10	M3596
Coexpression	GSE37301_MULTIPOTENT_PROGENITOR_VS_PRO_BCELL_UP	C16orf89 MMS19 ADGRL1 LCT CIT RAX CSF2RA PKP3 CDH16 EPHA8	5.73e-06	200	212	10	M8843
Coexpression	GSE6269_HEALTHY_VS_STAPH_AUREUS_INF_PBMC_DN	EVPL TUBGCP2 F7 BTF3 DOCK6 LRRC41 HEYL CSF2RA PKP3	1.48e-05	177	212	9	M5656
CoexpressionAtlas	Myeloid Cells, DC.8+.SLN, CD11b-FITC CD4-PE CD11c-Alexa750 CD8a-PacificBlue, Lymph Node, avg-3	MYCL HK3 MAN2B1 DOCK5 JAK2 ALMS1 LPCAT2 SEMA4F NR4A3 TBC1D8 ARHGAP5 SLC11A1 CSF2RA GRAMD2B ASB2 HPS5	5.52e-06	425	210	16	GSM538255_500
CoexpressionAtlas	Myeloid Cells, DC.8+.MLN, CD11b-FITC CD4-PE CD11c-Alexa750 CD8a-PacificBlue, Lymph Node, avg-3	MYCL HK3 MAN2B1 DOCK5 JAK2 ALMS1 ZC3H12D SEMA4F NR4A3 TBC1D8 ARHGAP5 SLC11A1 CSF2RA ASB2 HPS5	2.03e-05	420	210	15	GSM538252_500
ToppCell	wk_15-18-Epithelial-Distal_epithelial-type_II_pneumocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CFTR EVPL C16orf89 LAMB3 LLGL2 IL17RE PKP3 IRX2 AGRN CDH16	3.87e-08	195	214	10	0e3aac1b1a1fd483f5fb9a394eb90c0e1ce63542
ToppCell	wk_20-22-Epithelial-Distal_epithelial\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CFTR EVPL C16orf89 LAMB3 GPRC5A IL17RE PKP3 IRX2 AGRN CDH16	4.06e-08	196	214	10	cd507ee2baf4f52d6498811b3510d3164b56311f
ToppCell	Parenchyma_Control_(B.)-Stromal-TX-Smooth_muscle-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	STXBP4 MATN3 OBSCN PLEKHH3 PHLDB1 INSC DOCK6 NOTCH3 HEYL HES4	4.91e-08	200	214	10	0c648941447c738caf62f2d71e296d6cca492c8b
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Smooth_muscle-1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	STXBP4 MATN3 OBSCN PLEKHH3 PHLDB1 INSC DOCK6 NOTCH3 HEYL HES4	4.91e-08	200	214	10	522a51a284d2992d519c4669e1a48c8ebcc08c80
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Smooth_muscle-1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	STXBP4 MATN3 OBSCN PLEKHH3 PHLDB1 INSC DOCK6 NOTCH3 HEYL HES4	4.91e-08	200	214	10	94f1fa61aa82eb9f411b2b1cb759476939ab5db7
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CFTR RNF145 DNAH5 WWC1 NOTCH3 GRIK2 GPRC5A HES4 RIMS1	2.33e-07	180	214	9	b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCell	PND07-28-samps-Epithelial-Alveolar_epithelial-AT2\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	CFTR ACOT7 C16orf89 WWC1 LAMB3 GPRC5A LLGL2 IRX2 CDH16	2.68e-07	183	214	9	0a69e22750dd8b66ab988cf36d0dd2b59e2f7d26
ToppCell	PND07-28-samps-Epithelial-Alveolar_epithelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	CFTR ACOT7 C16orf89 WWC1 LAMB3 GPRC5A LLGL2 IRX2 CDH16	2.68e-07	183	214	9	23e55f88a802a9299d2773f9394970e86e8bbfaa
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTTNBP2 C16orf89 KCNS1 NOTCH3 MOS TPPP RFLNB HEY1 BRINP2	3.07e-07	186	214	9	4ae3c0fe8640a8d029875cf3f0f5ffbba38e85f8
ToppCell	Adult-Epithelial-club_cell\|Adult / Lineage, Cell type, age group and donor	CFTR TTPA DNAH5 WWC1 NOTCH3 GRIK2 GRAMD2B HES4 RIMS1	3.67e-07	190	214	9	756bff697d30aec56c0ebfca94295f084a15bf37
ToppCell	Epithelial-club_cell\|World / Lineage, Cell type, age group and donor	CFTR TTPA RNF145 DNAH5 WWC1 GRIK2 GPRC5A GRAMD2B RIMS1	4.19e-07	193	214	9	2bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS-RAS\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFTR C16orf89 RNF145 WWC1 GRIK2 GPRC5A GRAMD2B LRP5 RIMS1	4.38e-07	194	214	9	a58841b34efe673671a9a059238e044a7254b279
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFTR C16orf89 RNF145 WWC1 GRIK2 GPRC5A GRAMD2B LRP5 RIMS1	4.38e-07	194	214	9	0cd4363627acd419e00d6d32f6dce10430aa6487
ToppCell	(7)_Epithelial-I_(AT1)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	MATN3 FAM174B WWC1 LAMB3 GPRC5A LLGL2 IL17RE IRX2 AGRN	4.77e-07	196	214	9	150554fa06868d29b0608189862eef6505ba757f
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	EVPL C16orf89 WWC1 LAMB3 LLGL2 IL17RE RIMBP2 IRX2 CDH16	4.98e-07	197	214	9	2f91b3870a7058168093a143110954c07588cfe9
ToppCell	Bronchial-10x5prime-Epithelial-Epi_alveolar-AT1\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FAM174B EVPL WWC1 LAMB3 GPRC5A LLGL2 LRP6 IRX2 AGRN	5.19e-07	198	214	9	54228dd9a50616d2022712d162a419ed0327cabd
ToppCell	Children_(3_yrs)-Immune-monocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HK3 INPP5D DOCK5 JAK3 SH2B3 DENND1A TBC1D8 SLC11A1 CSF2RA	5.65e-07	200	214	9	881ab995c90d75fd987d6e8f1f926a4bfcc4235f
ToppCell	Biopsy_IPF-Epithelial-SCGB3A2+\|Biopsy_IPF / Sample group, Lineage and Cell type	CFTR EVPL C16orf89 RNF145 PDLIM2 NOTCH3 GPRC5A CIT RIMS1	5.65e-07	200	214	9	2aaf130d702d18c277d16b6800f006a53ed653fb
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD16\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	HK3 INPP5D LPCAT2 IQSEC1 SH2B3 DENND1A TBC1D8 SLC11A1 CSF2RA	5.65e-07	200	214	9	fc061de0db2e8b5ca47f5e2a1e861018e7f1b582
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RNF145 DNAH5 AGBL1 GPRC5A CIT TBC1D8 IL17RE RIMS1	1.21e-06	162	214	8	5c9bc3c3857a99d8a3caf359a7eb279ce9cc1c81
ToppCell	356C-Epithelial_cells-Epithelial-D_(AT2)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	MATN3 CFTR SRSF12 WDR90 DCAF4L1 GPRC5A IRX2 SLX4	1.46e-06	166	214	8	2e4cb4056e6b0c43290a5588ff525f5f05b8beee
ToppCell	356C-Epithelial_cells-Epithelial-D_(AT2)\|356C / Donor, Lineage, Cell class and subclass (all cells)	MATN3 CFTR SRSF12 WDR90 DCAF4L1 GPRC5A IRX2 SLX4	1.46e-06	166	214	8	eb8d972326a734549675307e411fc795af66da70
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTTNBP2 HK3 P4HA3 IQGAP1 GPRC5A CSF2RA SLC41A1 DCLK1	1.90e-06	172	214	8	3f784aed340b50ddbec3f7dc0a5279180d38a2bb
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAM174B WWC1 LAMB3 GPRC5A LLGL2 IL17RE IRX2 AGRN	1.98e-06	173	214	8	45808cf69122c16b9d2b5ffa06d15392c55954b7
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAM174B WWC1 LAMB3 GPRC5A LLGL2 IL17RE IRX2 AGRN	1.98e-06	173	214	8	7fa9dbcb258c3ab974490063951620e2def03db1
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	GPR179 RNF145 DNAH5 GRIK2 GPRC5A TBC1D8 GRAMD2B RIMS1	2.25e-06	176	214	8	3bbac5c2397535631fce8fa98f6ddb4fe0260351
ToppCell	facs-Heart-RA-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPEG AP5Z1 SCN3A NOTCH3 GP1BB ADGRL1 USP2 HEY2	2.56e-06	179	214	8	d76a05f1fee7f2f7b7b7994d3622e96f02b49432
ToppCell	facs-Heart-RA-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPEG AP5Z1 SCN3A NOTCH3 GP1BB ADGRL1 USP2 HEY2	2.56e-06	179	214	8	6be47c877250968a916c711ba0787eb7b4c5443d
ToppCell	AT1_cells-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	MATN3 FAM174B LAMB3 GPRC5A LLGL2 IL17RE IRX2 AGRN	2.66e-06	180	214	8	2d52cb5f77dde0e3dccac1333d4ec67ec680fcb2
ToppCell	COVID-19-lung-AT1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FAM174B EVPL WWC1 LAMB3 GPRC5A LLGL2 IL17RE IRX2	3.01e-06	183	214	8	7b1a385ed54f93bfe85bf0c162e42d05d516b45c
ToppCell	Adult-Mesenchymal-pericyte_cell-D122\|Adult / Lineage, Cell type, age group and donor	MATN3 OBSCN PHLDB1 INSC DOCK6 NOTCH3 HEYL HES4	3.01e-06	183	214	8	fc31a43a637423cb3bb9aa184a3a889a0b9aaea6
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAM174B RNF145 DNAH5 AGBL1 WWC1 GPRC5A CIT IRX2	3.13e-06	184	214	8	102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTGIS SCN3A WDR90 NOTCH3 HEYL HEY2 ZFHX3 ASB2	3.26e-06	185	214	8	38486b69c48dc5e1c4e1488208fa8954a973eccb
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTGIS SCN3A WDR90 NOTCH3 HEYL HEY2 ZFHX3 ASB2	3.26e-06	185	214	8	3c28b5ceba3cfdb6f7e32d5b42e03b6a81a7a658
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CFTR RNF145 DNAH5 AGBL1 WWC1 GPRC5A CIT LLGL2	3.40e-06	186	214	8	2ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell	AT1_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	MATN3 PDLIM2 TPPP LAMB3 GPRC5A LLGL2 BRINP2 AGRN	3.53e-06	187	214	8	f1dda349335e08dbfc8395d373924037f5ad2fd6
ToppCell	Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|World / Lineage, Cell type, age group and donor	CFTR FAM174B RNF145 DNAH5 AGBL1 WWC1 GPRC5A CIT	3.53e-06	187	214	8	81cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	STXBP4 OBSCN PHLDB1 DOCK6 NOTCH3 HEYL HES4 ZFHX3	3.53e-06	187	214	8	86250acf088ec0c4800a0dfa031b0d4f7e52c342
ToppCell	Adult-Mesenchymal-pericyte_cell\|Adult / Lineage, Cell type, age group and donor	MATN3 OBSCN PHLDB1 INSC DOCK6 NOTCH3 HEYL HES4	3.53e-06	187	214	8	62759efb660179402fb574ce5701c89a2e17bcfe
ToppCell	E12.5-Epithelial-alveolar_epithelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CFTR FAM174B LAMB3 GPRC5A LLGL2 IL17RE IRX2 CDH16	3.68e-06	188	214	8	c19c89756f2f999e0814f08a89818ef156f6fc69
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPEG PTGIS NOTCH3 GRIK2 HEYL HEY1 HEY2 ZFHX3	3.68e-06	188	214	8	d1a4cd4db95d8d32b79156290f7867f32824cc87
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	STXBP4 OBSCN PHLDB1 INSC DOCK6 NOTCH3 HEYL HES4	3.68e-06	188	214	8	ee151792c7ac9afe820f1a281c6dab383799f358
ToppCell	COVID-19-lung-Secretory\|lung / Disease (COVID-19 only), tissue and cell type	CFTR DNAH5 DSC3 LAMB3 GRIK2 GPRC5A GRAMD2B RIMS1	3.82e-06	189	214	8	84d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCell	P03-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	INSC NOTCH3 GP1BB HEYL SLC11A1 HEY2 ZFHX3 DCLK1	3.82e-06	189	214	8	b5439ef221106f6d54434f268485e9bb17b39102
ToppCell	E17.5-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FAM174B C16orf89 PDLIM2 LAMB3 GPRC5A LLGL2 IL17RE CDH16	3.97e-06	190	214	8	15f314517ed47b12d287a12a7d18cb383310e25a
ToppCell	PND07-Epithelial-Epithelial_Alveolar\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFTR C16orf89 WWC1 LAMB3 GPRC5A LLGL2 IRX2 CDH16	3.97e-06	190	214	8	ee39fb88f31d2d65b5d3e7416db68f5df07f6637
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFTR C16orf89 WWC1 LAMB3 GPRC5A LLGL2 IRX2 CDH16	3.97e-06	190	214	8	33d1b0a38267270e87702ba5794f07233acf4955
ToppCell	facs-Lung-3m-Epithelial-alveolar_epithelial-type_II_pneumocyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFTR ACOT7 WWC1 SEMA4F LAMB3 GPRC5A IRX2 CDH16	4.13e-06	191	214	8	210589095a3f5d5117174caf6ec110b502f27030
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAM174B C16orf89 WWC1 LAMB3 GPRC5A LLGL2 IL17RE AGRN	4.13e-06	191	214	8	ce76b156b153a2c7c9f2fb8e563b69c81073fbe5
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	STXBP4 MATN3 OBSCN INSC DOCK6 NOTCH3 HEYL HES4	4.13e-06	191	214	8	1626b23a57429f835fddc052e3c57f63a4e5b8bb
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPEG SCN3A NOTCH3 USP2 HEYL HEY2 ASB2 HCRTR1	4.13e-06	191	214	8	8e8beb8e8a3b33cac83d3f7ce915a71e3654fdab
ToppCell	facs-Lung-3m-Epithelial-alveolar_epithelial-type_II_pneumocyte-type_2_alveolar_epithelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFTR ACOT7 WWC1 SEMA4F LAMB3 GPRC5A IRX2 CDH16	4.13e-06	191	214	8	f98fc372e579ce69409afbbe0f83c03c7ea62632
ToppCell	Children_(3_yrs)-Epithelial-club_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TTPA RNF145 DNAH5 WWC1 GRIK2 GPRC5A GRAMD2B HES4	4.13e-06	191	214	8	23776c7302cead3881b39127398f3b3e0d27885e
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAM174B C16orf89 WWC1 LAMB3 GPRC5A LLGL2 IL17RE AGRN	4.13e-06	191	214	8	c006f5a6e3a32b79ac99a78304bdd5116fc0d5e0
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	STXBP4 MATN3 OBSCN INSC DOCK6 NOTCH3 HEYL HES4	4.13e-06	191	214	8	716dfa7fccbd62b5f574792e68a26dc6c45511dc
ToppCell	P07-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FAM174B C16orf89 WWC1 LAMB3 GPRC5A LLGL2 IL17RE IRX2	4.13e-06	191	214	8	0f360766490bef3495c42f6421b22a988cfc68fb
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SPEG JAK2 SCN3A NOTCH3 HEYL HES4 ZFHX3 ASB2	4.29e-06	192	214	8	bfab13793e54de2550ee171397f7ece0625cdb4a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SPEG JAK2 SCN3A NOTCH3 HEYL HES4 ZFHX3 ASB2	4.29e-06	192	214	8	b54b0d5b88139905521c8d5d58332e89c08d589c
ToppCell	facs-Lung-3m-Epithelial-alveolar_epithelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFTR ACOT7 WWC1 SEMA4F LAMB3 GPRC5A IRX2 CDH16	4.29e-06	192	214	8	4a46f7980ec145be5b4bf8b98265e3e0f2ea4c63
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-Pericytes\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLEKHH3 PDLIM2 NOTCH3 DSC3 HEYL HEY2 HES4 ZFHX3	4.46e-06	193	214	8	47d189bac0ef4df2f5c6dd987e46aca85bd7e2af
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTGIS INSC NOTCH3 HEYL SLC11A1 HEY2 ZFHX3 DCLK1	4.46e-06	193	214	8	323d1f3f4fbeb93ba857fc135d8aa0b897f98ac5
ToppCell	E16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-Sox9_Epi-Sox9_Epi_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IQGAP1 C16orf89 WWC1 LAMB3 GPRC5A LLGL2 IRX2 CDH16	4.46e-06	193	214	8	33c495a2a7252b48ce10321642fd675d03cc80fc
ToppCell	E16.5-samps-Epithelial-Alveolar_epithelial_precursor\|E16.5-samps / Age Group, Lineage, Cell class and subclass	CFTR C16orf89 INSC WWC1 LAMB3 GPRC5A IRX2 CDH16	4.46e-06	193	214	8	c1817ad675b9f9d2d3436c8b9646edf89f0d4c82
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPEG PTGIS NOTCH3 HEYL HEY2 ZFHX3 ASB2 HCRTR1	4.46e-06	193	214	8	7766f495f2f945802ef9a5b994cd00bb64d0dfe3
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPEG PTGIS NOTCH3 HEYL HEY2 ZFHX3 ASB2 HCRTR1	4.46e-06	193	214	8	ce3e8cf30b7b4d5c7a8f3d64c21d81d2c3cab5c1
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPEG PTGIS NOTCH3 HEYL SLC11A1 HEY2 ZFHX3 DCLK1	4.46e-06	193	214	8	469a7f1c2ff7137cc5a064464456911f67f92e70
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPEG PTGIS NOTCH3 HEYL HEY2 ZFHX3 ASB2 HCRTR1	4.46e-06	193	214	8	18e11d515147accef9aee26e934b358b445e18e2
ToppCell	E16.5-samps-Epithelial\|E16.5-samps / Age Group, Lineage, Cell class and subclass	CFTR C16orf89 INSC WWC1 LAMB3 GPRC5A IRX2 CDH16	4.46e-06	193	214	8	1cb5a1cffa2b4a3bfecca16b791c1992edeb237d
ToppCell	E18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAM174B IQGAP1 C16orf89 PDLIM2 WWC1 GPRC5A LLGL2 AGRN	4.63e-06	194	214	8	ad3eb98f94a007c5988ede06238255f5b03bee6e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPEG PTGIS JAK2 NOTCH3 HEYL HES4 ZFHX3 ASB2	4.63e-06	194	214	8	5c3b2b05d1e4f146551fe4c920263d8e6ca34de3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPEG PTGIS JAK2 NOTCH3 HEYL HES4 ZFHX3 ASB2	4.63e-06	194	214	8	ab9cad697f9209d2889bc02b43b502dfeb2ebfef
ToppCell	E18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAM174B IQGAP1 C16orf89 PDLIM2 WWC1 GPRC5A LLGL2 AGRN	4.63e-06	194	214	8	a281ebab117589fc922ead0a712cfe0a844c94ac
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	EVPL C16orf89 WWC1 LAMB3 LLGL2 RIMBP2 IRX2 CDH16	4.81e-06	195	214	8	f08e41706680881ebd0afcd08a02f8ac0089f04e
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MATN3 FAM174B PDLIM2 GPRC5A LLGL2 IL17RE IRX2 AGRN	4.81e-06	195	214	8	2a1863f4b9fe73c30b0b1acf9b12fc98ef65040f
ToppCell	E16.5-Epithelial\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IQGAP1 C16orf89 WWC1 LAMB3 GPRC5A LLGL2 IRX2 CDH16	4.81e-06	195	214	8	e2d9856e4bd6259f0988cfefd7ce364f15681bf8
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MATN3 FAM174B PDLIM2 GPRC5A LLGL2 IL17RE IRX2 AGRN	4.81e-06	195	214	8	68f4cc84b5ae7f4159b780c78e4b66c94211779a
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPEG PTGIS INSC NOTCH3 HEYL HEY2 ZFHX3 DCLK1	4.81e-06	195	214	8	43d372373367b71243c6ea958aedccde4478618f
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	EVPL C16orf89 WWC1 LAMB3 LLGL2 RIMBP2 IRX2 CDH16	5.00e-06	196	214	8	0a34a0009f479384f1994c6f977f942699a132c8
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPEG OBSCN COQ8A NRAP LAMB3 ASB2 CDH16 MYBPC3	5.00e-06	196	214	8	a582130862bee76c0385156a333bfdfc75cf218b
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPEG OBSCN COQ8A NRAP LAMB3 ASB2 CDH16 MYBPC3	5.00e-06	196	214	8	fba52a4b82086dbae9a55038bf44c4539be926f5
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MATN3 FAM174B PDLIM2 LAMB3 GPRC5A IL17RE IRX2 AGRN	5.19e-06	197	214	8	734b8db5bb4917c9ce92ed342fe6c22b64b0d3c5
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MATN3 FAM174B PDLIM2 LAMB3 GPRC5A IL17RE IRX2 AGRN	5.19e-06	197	214	8	e344455e62b3fe94bb242dc0db58d19a1d3878c7
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MATN3 FAM174B PDLIM2 LAMB3 GPRC5A IL17RE IRX2 AGRN	5.19e-06	197	214	8	c9c968e223e7814cd8d22975d849a31b7e0af7aa
ToppCell	AT1_cells-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	MATN3 FAM174B PDLIM2 LAMB3 GPRC5A LLGL2 IRX2 AGRN	5.19e-06	197	214	8	80d81be244c94c435accb643449b4ce6a3462c7f
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	EVPL C16orf89 WWC1 LAMB3 LLGL2 RIMBP2 IRX2 CDH16	5.19e-06	197	214	8	6852a8ec1397811bbdd1fc625c52ed4fa75a931e
ToppCell	15-Distal-Epithelial\|Distal / Age, Tissue, Lineage and Cell class	C16orf89 WWC1 LAMB3 GPRC5A IL17RE PKP3 IRX2 CDH16	5.19e-06	197	214	8	9fbd1abf050b364155a67962a9731118304f72fb
ToppCell	wk_15-18-Epithelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	EVPL C16orf89 WWC1 LAMB3 IL17RE PKP3 IRX2 CDH16	5.38e-06	198	214	8	12bbe77c3d68bf1e545949dbb1eb49ed3641de3d
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RNF145 DNAH5 WWC1 NOTCH3 GRIK2 GPRC5A CIT RIMS1	5.38e-06	198	214	8	af399569c718f5fd971d73a7926768c9311002a3
ToppCell	mLN-(5)_Dendritic_cell-(53)_Lymphoid_DC\|mLN / shred on region, Cell_type, and subtype	CTTNBP2 SRSF12 LPCAT2 LAMB3 FAM171B TBC1D8 CSF2RA HEY1	5.38e-06	198	214	8	da84c76afe835aeee39da04b63c03549218b5d91
ToppCell	mLN-Dendritic_cell-Lymphoid_DC\|mLN / Region, Cell class and subclass	CTTNBP2 SRSF12 LPCAT2 LAMB3 FAM171B TBC1D8 CSF2RA HEY1	5.38e-06	198	214	8	3965a9f1e8a51a196e5349aaca5fa5ed1cd8ee92
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Transitional_AT2\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	FAM174B C16orf89 WWC1 LAMB3 GPRC5A LLGL2 PKP3 IRX2	5.59e-06	199	214	8	b44d74895846e2ac144438b73e0ca91e3949c16c
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-AT1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FAM174B WWC1 LAMB3 GPRC5A LLGL2 IL17RE IRX2 AGRN	5.59e-06	199	214	8	f8846446ebbc4948cdc69640782db1358bbdc486
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX-Transitional_AT2\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	FAM174B C16orf89 WWC1 LAMB3 GPRC5A LLGL2 PKP3 IRX2	5.59e-06	199	214	8	9e8231c9007d8d963805a4c99e0905538ceb9b60
ToppCell	Parenchyma_COVID-19-Epithelial-TX-AT1\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	FAM174B WWC1 LAMB3 GPRC5A LLGL2 IL17RE IRX2 AGRN	5.59e-06	199	214	8	fe9f5bc317be0c35bd96311bf0b3c7b91d98acc5
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-AT1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	FAM174B WWC1 LAMB3 GPRC5A LLGL2 IL17RE IRX2 AGRN	5.59e-06	199	214	8	3e35ee426ef06f9af568c37349b62dd1ee9b97ea
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Transitional_AT2-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FAM174B C16orf89 WWC1 LAMB3 GPRC5A LLGL2 PKP3 IRX2	5.59e-06	199	214	8	4b374a5de82b4614d3d8a00202ea6cb8f1fd8104
ToppCell	mild-cDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	JAK2 LPCAT2 SH2B3 NR4A3 CCDC6 ARHGAP5 CSF2RA ZFHX3	5.80e-06	200	214	8	86f585bf9066b179bbcbc703bf43f15da4a07284
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-AT1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	MATN3 FAM174B LAMB3 GPRC5A LLGL2 PKP3 IRX2 AGRN	5.80e-06	200	214	8	5f7e8d8b05c90a10313775f9f126eb4ab0fe4f67
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Monocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	HK3 INPP5D IQSEC1 SH2B3 DENND1A TBC1D8 SLC11A1 CSF2RA	5.80e-06	200	214	8	fd72fe6565e2f4885481991492d58c323ab1ad40
ToppCell	distal-Epithelial\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	C16orf89 RNF145 DNAH5 WWC1 LAMB3 GPRC5A PKP3 IRX2	5.80e-06	200	214	8	0a97080f694738bb882787cee21b91a4d5757b7a
Disease	Gastric Adenocarcinoma	SPEG JAK3 WEE2 DCLK1 EPHA8	1.43e-05	45	203	5	C0278701
Disease	methionine sulfone measurement	CDK12 ALMS1 CEP89	6.74e-05	12	203	3	EFO_0800072
Disease	familial erythrocytosis 1 (is_implicated_in)	JAK2 SH2B3	1.41e-04	3	203	2	DOID:0060652 (is_implicated_in)
Disease	ERYTHROCYTOSIS, FAMILIAL, 1	JAK2 SH2B3	1.41e-04	3	203	2	133100
Disease	Primary familial polycythemia due to EPO receptor mutation	JAK2 SH2B3	1.41e-04	3	203	2	cv:C4551637
Disease	MYELOFIBROSIS	JAK2 SH2B3	2.80e-04	4	203	2	254450
Disease	Primary myelofibrosis	JAK2 SH2B3	2.80e-04	4	203	2	cv:C0001815
Disease	primary biliary cholangitis (implicated_via_orthology)	JAK2 ZC3H12A	2.80e-04	4	203	2	DOID:12236 (implicated_via_orthology)
Disease	Chronic myeloproliferative disorder	WDR4 JAK3 PCNT	2.87e-04	19	203	3	C1292778
Disease	polycystic liver disease (is_implicated_in)	GANAB LRP5	4.65e-04	5	203	2	DOID:0050770 (is_implicated_in)
Disease	Essential thrombocythemia	JAK2 SH2B3	4.65e-04	5	203	2	cv:C0040028
Disease	Carcinoma, Pancreatic Ductal	NOTCH3 HEY1 HEY2	5.84e-04	24	203	3	C0887833
Disease	essential thrombocythemia (is_implicated_in)	JAK2 SH2B3	6.94e-04	6	203	2	DOID:2224 (is_implicated_in)
Disease	nonsyndromic deafness (implicated_via_orthology)	MTO1 LRP5	6.94e-04	6	203	2	DOID:0050563 (implicated_via_orthology)
Disease	Familial erythrocytosis	JAK2 SH2B3	6.94e-04	6	203	2	cv:C0152264
Disease	Primary Myelofibrosis	JAK2 SH2B3	6.94e-04	6	203	2	C0001815
Disease	mean platelet volume	CDK12 ACOX1 DOCK5 JAK2 UBN1 KCNS1 RNF145 GP1BB SEMA4F PCDHGC5 TRMT1 VWA7 SHANK3 NLRP6 MCM9 TRIM40 MYBPC3	7.33e-04	1020	203	17	EFO_0004584
Disease	brain cancer (implicated_via_orthology)	NOTCH3 LLGL2 HES4	7.42e-04	26	203	3	DOID:1319 (implicated_via_orthology)
Disease	disease of cellular proliferation (implicated_via_orthology)	JAK2 JAK3	9.67e-04	7	203	2	DOID:14566 (implicated_via_orthology)
Disease	level of oxylipin in blood plasma	LPCAT2 GRIK2	9.67e-04	7	203	2	OBA_2050338
Disease	central nervous system cancer (implicated_via_orthology)	NOTCH3 HES4	9.67e-04	7	203	2	DOID:3620 (implicated_via_orthology)
Disease	1,5 anhydroglucitol measurement	PCDHA8 PCDHA7 PCDHA6	1.03e-03	29	203	3	EFO_0008009
Disease	myelofibrosis (is_implicated_in)	JAK2 SH2B3	1.28e-03	8	203	2	DOID:4971 (is_implicated_in)
Disease	Polycythemia Vera	JAK2 SH2B3	1.28e-03	8	203	2	C0032463
Disease	hemangiopericytoma (is_marker_for)	HEY1 HEY2	1.64e-03	9	203	2	DOID:264 (is_marker_for)
Disease	Erythrocytosis familial, 1	JAK2 SH2B3	1.64e-03	9	203	2	C4551637
Disease	Thrombocytosis, Autosomal Dominant	JAK2 SH2B3	1.64e-03	9	203	2	C3489628
Disease	Global developmental delay	TMEM94 SPART IQSEC1 SZT2 TRMT1	2.31e-03	133	203	5	C0557874
Disease	glycerophosphorylcholine measurement	MYCL EPHA8	2.49e-03	11	203	2	EFO_0020018
Disease	post-traumatic stress disorder symptom measurement	CTTNBP2 PCDHA8 PCDHA7 PCDHA6	2.50e-03	82	203	4	EFO_0008535
Disease	Inherited neuropathies	SPART TTPA COQ8A	2.63e-03	40	203	3	C0598589
Disease	serum albumin measurement	CDK12 PEPD ARMC2 SH2B3 GRIK2 SCGN CCDC6 HEYL ASB2 PCNT MYBPC3	2.80e-03	592	203	11	EFO_0004535
Disease	type 1 diabetes mellitus (is_implicated_in)	F7 PRRC2A SH2B3 SLC11A1	2.85e-03	85	203	4	DOID:9744 (is_implicated_in)
Disease	Hematologic Neoplasms	JAK2 SH2B3	2.97e-03	12	203	2	C0376545
Disease	Thromboembolism	F7 JAK2	2.97e-03	12	203	2	C0040038
Disease	Thrombocythemia, Essential	JAK2 SH2B3	2.97e-03	12	203	2	C0040028
Disease	visceral adipose tissue measurement, body mass index	PCDHA8 PCDHA7 PCDHA6 GRAMD2B	3.10e-03	87	203	4	EFO_0004340, EFO_0004765
Disease	neutrophil count	INPP5D PEPD NCLN JAK2 COQ8A IQSEC1 GRIN3B DOCK6 SH2B3 PCDHA8 PCDHA7 PCDHA6 VWA7 LCT CIT TBC1D8 TNXB HCRTR1 PCNT	3.32e-03	1382	203	19	EFO_0004833
Disease	Congenital Heart Defects	TMEM94 GDF1 GP1BB	3.45e-03	44	203	3	C0018798
Disease	hematologic cancer (implicated_via_orthology)	JAK2 JAK3	3.49e-03	13	203	2	DOID:2531 (implicated_via_orthology)
Disease	tetralogy of Fallot (implicated_via_orthology)	DNAH5 HEY2	4.06e-03	14	203	2	DOID:6419 (implicated_via_orthology)
Disease	Situs ambiguus	GDF1 DNAH5	4.66e-03	15	203	2	C0266642
Disease	lung adenocarcinoma (is_implicated_in)	JAK2 IQSEC1 ZFHX3	4.68e-03	49	203	3	DOID:3910 (is_implicated_in)
Disease	interferon gamma measurement, platelet-derived growth factor BB measurement, interleukin 4 measurement, interleukin 10 measurement, stromal cell-derived factor 1 alpha measurement, interleukin-6 measurement, interleukin 12 measurement, interleukin 17 measurement, vascular endothelial growth factor measurement, fibroblast growth factor basic measurement, granulocyte colony-stimulating factor measurement	KCNV2 MEN1	5.30e-03	16	203	2	EFO_0004750, EFO_0004753, EFO_0004762, EFO_0004810, EFO_0008130, EFO_0008142, EFO_0008165, EFO_0008174, EFO_0008184, EFO_0008264, EFO_0008293
Disease	alcohol consumption measurement, high density lipoprotein cholesterol measurement	PEPD SH2B3 HEYL CDH16 MYBPC3	5.37e-03	162	203	5	EFO_0004612, EFO_0007878
Disease	alcohol consumption measurement	CTTNBP2 CDK12 P4HA3 GDF1 ALMS1 FAM227A WDR90 DNAH5 AGBL1 WWC1 CIT DENND1A HES4 ZFHX3 AGRN DCLK1 MYBPC3	5.64e-03	1242	203	17	EFO_0007878
Disease	eosinophil percentage of granulocytes	INPP5D JAK2 PCDHA6 IKZF4 LIMK2 ASB2	5.77e-03	234	203	6	EFO_0007996
Disease	Vitiligo	SH2B3 IKZF4	5.98e-03	17	203	2	C0042900
Disease	1-Methylhistidine measurement	CDK12 ALMS1	5.98e-03	17	203	2	EFO_0021543
Disease	Moyamoya Disease	RNF213 PCNT	5.98e-03	17	203	2	C0026654
Disease	sphingomyelin 14:0 measurement	ZFHX3 IRX2	5.98e-03	17	203	2	EFO_0010390
Disease	ulcerative colitis (is_implicated_in)	JAK2 SLC11A1	5.98e-03	17	203	2	DOID:8577 (is_implicated_in)
Disease	alcohol drinking, high density lipoprotein cholesterol measurement	PEPD SH2B3 HEYL CDH16 MYBPC3	6.24e-03	168	203	5	EFO_0004329, EFO_0004612
Disease	esophageal adenocarcinoma	CFTR TPPP	6.70e-03	18	203	2	EFO_0000478

Protein segments in the cluster

Peptide	Gene	Start	Entry
SRSTTEDFPLRLELA	TRBV6-6	86	A0A0A6YYG2
LAARFSDRTAVPREL	URAD	121	A6NGE7
VAALARVERTDFLSP	ACOT7	101	O00154
LRTEPSANSLAIERF	FAM227A	66	F5H4B4
LRAEAASRSEVPRLL	FAM246A	56	A0A494C0Y3
LRAEAASRSEVPRLL	FAM246B	56	A0A494C0N9
LRAEAASRSEVPRLL	FAM246C	56	P0DSO1
PSALASDRFNLILAD	DCAF4	166	Q8WV16
ADSLTSLRRLAEALP	BTF3	156	P20290
RLREEFSFIPSAALD	CDK12	981	Q9NYV4
SALERATVFLEQRLP	C16orf89	41	Q6UX73
LNERSLFRQAISPSD	CFTR	1431	P13569
LRALSRQDTFDADTP	CACNB1	491	Q02641
EALLSARFDVNTPLA	ASB2	386	Q96Q27
LLADNVREPARFLAA	ADGRL1	661	O94910
RDALLSQRSDPIFLD	CEACAM20	141	Q6UY09
FRAASQRALLPDRSL	ARMC2	136	Q8NEN0
LALLAAPAARASRAE	FAM174B	16	Q3ZCQ3
TTAFRAPDVARALLR	AGRN	1211	O00468
APLARFRDISDISFI	ALMS1	2281	Q8TCU4
PLFDRVLVERSAAET	HSPE1	11	P61604
RDANTALPLALRTVS	AP5Z1	781	O43299
ISPFRLEELTNRLAS	CCDC6	51	Q16204
RSLAAIEEAALLRSP	DNHD1	1901	Q96M86
DLLDFALSASRPESR	AHDC1	851	Q5TGY3
PLRSRASLIEVDLSD	CAMSAP1	1226	Q5T5Y3
RAVRAALTSTVPDLL	C5orf38	11	Q86SI9
AAEPIASRASRLNLF	CIT	16	O14578
LVSSDPVARLLRENF	AGBL1	821	Q96MI9
EAIDRRIPADTFAAL	IQGAP1	226	P46940
SELSAPRRNEDFVLL	GPRC5A	166	Q8NFJ5
SDNDRSSRLLLERPS	RBM15	686	Q96T37
LSPRVTERDLVSLFA	RBM41	316	Q96IZ5
RELFLSRQFESLPAT	MTA2	86	O94776
LADPARASFLNREVL	PEPD	426	P12955
SQRTDSARLRAPLDA	RFWD3	166	Q6PCD5
PSFRAIIRDLNSLFT	JAK2	796	O60674
LRRSPQDFDSFLLTV	JAK3	401	P52333
AIRRLPAFTLSHLES	NCLN	376	Q969V3
FSALTSVARALAPER	P4HA3	31	Q7Z4N8
ALTSLSLPVREDAQF	PCDHA6	351	Q9UN73
FPLRSIDDVVRLFAA	MEN1	11	O00255
TQRNLFIAESRPLDS	PCDHA7	136	Q9UN72
ESILASERLPFSCLR	RAB3GAP2	596	Q9H2M9
NSLSELRRLVPTAFE	HEY2	66	Q9UBP5
ESSLEDPLRSFVRVL	VCPKMT	6	Q9H867
ALTSLSLPVREDAQF	PCDHA8	351	Q9Y5H6
PLDLVFIIDSSRSVR	MATN3	81	O15232
VQLPAFRALEDRTIS	LLGL2	156	Q6P1M3
LDAIPFQTARASREI	NRAP	1531	Q86VF7
LLALTATRREFFPTA	GPR179	2256	Q6PRD1
CLFRTRPLDASDTLV	WWC1	711	Q8IX03
VLLPTAEERARALSA	HERC2	896	O95714
EPLLFSRDISRSESL	LIMK2	301	P53671
LEAVRSELREFPAAA	JMJD7	6	P0C870
RAVLASTPRFAEFLL	MMS19	246	Q96T76
EFRLSLRPDNADSRL	MTO1	496	Q9Y2Z2
LDAARARDTEPQTAL	IQSEC1	271	Q6DN90
ASEPVLESRRRNSAL	FRMD7	371	Q6ZUT3
RLELRFAAAAAAAPE	GDF1	146	P27539
RPEDQRSSFLESLLQ	HPS5	901	Q9UPZ3
RSSFLESLLQPESLR	HPS5	906	Q9UPZ3
DLRRISLDTPDFTDI	LRP5	351	O75197
FDLLPEARAIRVTIS	IL17RE	181	Q8NFR9
RLLRALDARPFAEAT	IL17RE	621	Q8NFR9
ISPDRFRSFEALLAD	DCLK1	76	O15075
IRSLDPSSLASDRFN	DCAF4L1	61	Q3SXM0
AAAARRLALAPDLST	CCDC120	126	Q96HB5
AAARLSLTDPLVAER	GP1BB	186	P13224
RDALPSNVEFLLARA	FBXO46	316	Q6PJ61
SLILRAVFRLPSQDA	OR52B2	221	Q96RD2
LALEPDAIRSRSNTL	PCDHGC5	801	Q9Y5F6
DPDAVARASRLASEL	EVPL	471	Q92817
PEELLRSSADFLQRL	NOTCH3	1521	Q9UM47
LSDLAQSDPEVRRAA	HEATR6	171	Q6AI08
LPASTLRRTEAFADL	LCT	136	P09848
RASVETSPLLRFRAE	MVD	216	P53602
RTDLRRISLDTPDFT	LRP6	336	O75581
SSLSELRRLVPTAFE	HEYL	61	Q9NQ87
PTVLVAVFRDLRDLS	SLC11A1	411	P49279
RQSRTFLVDPNLDLS	TUBGCP2	241	Q9BSJ2
EVSSRLLLAPSTRNF	KCNS1	286	Q96KK3
SADPFLETLTRLVRA	AMH	286	P03971
RLSFTVRSLLDLPEQ	NKX2-8	6	O15522
DSTQRTADIPALFLL	PRADC1	131	Q9BSG0
LAFLLPRLDTSNERT	MROH1	351	Q8NDA8
RFSSLVAATVRELAP	HK3	876	P52790
LPDRSSLLSEIQALR	PCNT	2511	O95613
SALAAPRSEELARSA	IRX2	26	Q9BZI1
NRLSAVPAEAARFLE	LRIT1	141	Q9P2V4
LAAREEASTSRLLQP	MORC2	656	Q9Y6X9
LVSELQPFLDRARSA	RIMS1	1101	Q86UR5
SSSAALRVREAPVLF	OBSCN	1976	Q5VST9
PVSDVLRQLFALFDR	LPCAT2	391	Q7L5N7
SSVLPELANRTRLFS	HCRTR1	186	O43613
ARLRLLSSVTAELPE	QTRT2	231	Q9H974
AVDFPSLRLDLRVAR	SLC35C1	101	Q96A29
RRERDSASFNPELLT	ACOX1	6	Q15067
REDFSLRLLTQFPNA	DOCK5	1391	Q9H7D0
IFDLRNLAADSLLPS	DOCK6	191	Q96HP0
ELRASLAALRLASPE	DOCK6	756	Q96HP0
ADLIRSSDPDFRVLN	DSC3	61	Q14574
SELLRDFLAPLENRS	CTTNBP2	1206	Q8WZ74
LLRRSDPAAFESRLE	ATPAF1	86	Q5TC12
ERPRSALAAAILATT	CEP89	46	Q96ST8
ASSFLPDIAQREERS	GALT	191	P07902
VLDALIRSPESLRAT	EPHA8	891	P29322
ARLDSQLEILSPSRS	FASTKD1	641	Q53R41
SSPFLSEANAERIVR	COQ8A	251	Q8NI60
LRRVQVTAALSADPA	HES4	91	Q9HCC6
ESLRLALASRLLPDF	IFRD2	161	Q12894
LDSVISALLADPTRR	MAN2B1	101	O00754
IRTLPLARSSARAAE	DENND1A	921	Q8TEH3
TRFFPASEALRSVLA	DHDH	126	Q9UQ10
AVTLARLSRDPDVAR	INSC	491	Q1MX18
LSLPRDLESLDRSFN	LAMB3	676	Q13751
NNSLSELRRLVPSAF	HEY1	66	Q9Y5J3
LLSSDAPRRIEESAI	PRPSAP2	301	O60256
AALAARSLLDVLPFD	CELSR3	1361	Q9NYQ7
LSLDRSLALAAEEPR	DZANK1	396	Q9NVP4
PDFSSLSRAILDLVQ	GRIK2	151	Q13002
AENSFRADRPSSLPL	GRAMD2B	231	Q96HH9
LLFRRENPLDSSVEF	SCGN	96	O76038
SSFPALELNNRRLSV	SDK2	1986	Q58EX2
FLRPSIAATQLDREL	CABP2	61	Q9NPB3
VPAAARAELSRSDLS	FAM171B	26	Q6P995
SSERPTFIDRLANSL	IKZF4	306	Q9H2S9
RDLSEALRAAPALTE	NLRP6	746	P59044
PISRTLRFSLVNDSE	CDH16	591	O75309
DLRTVAPASSLNVRF	CSF2RA	26	P15509
LNSVRRLLSDIFIPA	DNAH5	161	Q8TE73
AQRPSARLLLVDLTS	MOS	326	P00540
GLSSRSEDQRPLFAL	OR1L3	16	Q8NH93
LEIAAEFRLSAPVRD	MAP3K4	826	Q9Y6R4
FPSEVLTIFDSALRR	MCM9	61	Q9NXL9
ALVRALTDSTPRDLD	NR4A3	401	Q92570
AATETPVLSLLRREA	GRIN3B	121	O60391
EALRDITAARPSSVL	SZT2	2766	Q5T011
FPTADSTAVELVRLR	RIMBP2	541	O15034
LARSEESDLRFFLLP	SERAC1	181	Q96JX3
ERLSETSPAFRILSV	TRMT1	511	Q9NXH9
PAEAARILDISRAVT	TRIM40	186	Q6P9F5
PDDTLRALAALRLQS	PLEKHH3	531	Q7Z736
LARRVPDSLFRSLLE	TDRD6	196	O60522
SSLSLPDRVLTFIRD	SEMA4F	396	O95754
LSTLARLLFPAVDDN	TOP2B	831	Q02880
LLAPATRNRESEAFV	TIMM29	96	Q9BSF4
RQARASTPAILFLDE	SPATA5L1	551	Q9BVQ7
AATNRPDVLDTALLR	SPATA5L1	626	Q9BVQ7
AEPNRRVLETLASSL	LRRC41	181	Q15345
PALEASQRFRSISTL	LRRC41	451	Q15345
RRFLSSVELEAAELP	RFLNB	191	Q8N5W9
SESLRLTAAPFITRE	PTGIS	346	Q16647
LCLPERTFSERTLAF	F7	321	P08709
IPRNLSFIAALTERA	PPP1R3E	11	Q9H7J1
LTARPFRLDLLEDRS	GANAB	151	Q14697
LASTPDLRRFARSAL	KCNV2	321	Q8TDN2
VFSPDEALDRSLLAR	SLC9A3	756	P48764
LLSRFSREEFPTLQA	PRRC2A	161	P48634
RTLPSLESLQRLFDQ	INPP5D	226	Q92835
SPDVNSRSARVLFLL	SLC41A1	401	Q8IVJ1
SSAREIENLPLRLFT	STEAP2	196	Q8NFT2
PESFRLFTRESLAAI	SCN3A	11	Q9NY46
RLLREELAAASSAAF	PKN1	286	Q16512
NDRRIPFDLLSTLEA	ARHGAP5	396	Q13017
RELFLSRQLESLPAT	MTA1	106	Q13330
TPLSNLSERRAVLAS	STXBP4	446	Q6ZWJ1
PRQSSSFRLLQEALE	PDLIM2	236	Q96JY6
SLFIRNVADATRPED	SRSF12	11	Q8WXF0
DERLPRIAFFATRTI	SUV39H1	341	O43463
DEADPRNSSIAALRL	RAX	316	Q9Y2V3
AAVPALRLESAFSER	SLX4	436	Q8IY92
LRLESAFSERIRPEA	SLX4	441	Q8IY92
RLPDDRFLNSTAISQ	BRINP2	346	Q9C0B6
RPEIVLDISSRALAF	CCNB1IP1	81	Q9NPC3
SLADFSPAEINRRLR	CHST13	151	Q8NET6
RVDNIRSATPEALAF	CHAT	566	P28329
RVFDLQFSTDSPRLL	NCAPH	71	Q15003
SVRPLLLRTFSDESN	ATP11C	1116	Q8NB49
RLRELPLAADALTFA	PKP3	576	Q9Y446
LADRSVRFPNDVLFL	PPP1R27	21	Q86WC6
TPATTFEEVALLLRR	RNF213	1866	Q63HN8
VRFLDNSLDTVLNRP	SPART	251	Q8N0X7
TPSARLLFTAARNEI	WDR90	1726	Q96KV7
RSVADELRANALLSP	ZC3H12A	331	Q5D1E8
RAARLRTASVPLDAV	MRPL38	121	Q96DV4
DLRALRSDFLSLPFQ	TDRKH	401	Q9Y2W6
DLRSRFLALRDQVPT	MYCL	296	P12524
AVFVLLEERRPADSA	TFE3	21	P19532
TRQRSPASDLELRFA	SPEG	481	Q15772
LRPDIADADSRAATV	SHANK3	726	Q9BYB0
FALVPLLREASARDR	TRPV1	791	Q8NER1
ALSRPVTALDNERFT	TMEM94	261	Q12767
LPRRSLAELSEASLA	RNF222	166	A6NCQ9
LAELSEASLAPRSAR	RNF222	171	A6NCQ9
AVLDSNARVAPFRIL	TBC1D8	51	O95759
SVFSARDRDPNSLLI	TNXB	4166	P22105
PRDDLFDRLTTTSLN	TOP1MT	396	Q969P6
APLRAELVSLQFTDL	SH2B3	56	Q9UQQ2
RLRDADVQFLASVLP	NAPRT	71	Q6XQN6
TLSNEFDRRFVLLPN	PKHD1L1	1646	Q86WI1
REFSLRLESAAPSQT	TRBV6-1	91	A0A0K0K1D8
LTDSPAATVLAEARR	PHLDB1	331	Q86UU1
PLTDSFLLRFLRARD	TTPA	46	P49638
RDAAARLTISSPLEA	SF3B3	146	Q15393
PAVSDARSDLLSAIR	WASF2	431	Q9Y6W5
DFRTLASSLRPIVID	ZC3H12D	81	A2A288
SDPTVFLDRLAVIFR	TNPO3	606	Q9Y5L0
PDTVDDLFRLATRFI	TNPO3	746	Q9Y5L0
RLNTEDFPLRLVSAA	TRBV6-8	86	A0A0A6YYG3
PELSALEEAFRRFAV	TPPP	46	O94811
AAAAVRITLTLFEPD	UBN1	41	Q9NPG3
PLDFRLDSSAVHRIL	VPS13B	581	Q7Z7G8
LRRISAVDSTDFNPD	TRMT9B	376	Q9P272
VAVSPDDRFILTADR	WDR4	151	P57081
SAAALARNTVLRPSL	WEE2	476	P0C1S8
AEALLSQSRDPRALL	TARBP1	6	Q13395
TTFVNFPLRDLDLRE	USP2	516	O75604
DQPASRERLLFLFLT	RNF145	251	Q96MT1
DRDFSRLLDITPASS	VWA7	301	Q9Y334
SSFPLDAILNARRAA	TRIM62	76	Q9BVG3
PALRSETARRLLNDT	WDR87	916	Q6ZQQ6
TADEVRLLNRPSAFD	ZRANB1	296	Q9UGI0
ALARPRTEVSLSAFA	TRAPPC5	16	Q8IUR0
DSLRAPFNERLAEST	ZFHX3	51	Q15911
DFVLRRDLSATAPAA	ZIC5	196	Q96T25
IRNSPTDTILFIRAA	MYBPC3	1021	Q14896