Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor activity	GABRA1 GABRA3 GABRA4	1.78e-05	11	97	3	GO:0008503
GeneOntologyMolecularFunction	GABA-gated chloride ion channel activity	GABRA1 GABRA3 GABRA4	8.60e-05	18	97	3	GO:0022851
GeneOntologyMolecularFunction	GABA-A receptor activity	GABRA1 GABRA3 GABRA4	1.02e-04	19	97	3	GO:0004890
GeneOntologyMolecularFunction	GABA receptor activity	GABRA1 GABRA3 GABRA4	1.60e-04	22	97	3	GO:0016917
GeneOntologyMolecularFunction	retinoic acid binding	IGF2R UGT2B15 UGT2B17	3.33e-04	28	97	3	GO:0001972
GeneOntologyMolecularFunction	hexosyltransferase activity	B3GNT7 AGL UGT2B15 UGT2B17 UGT2B11 MGAT5B	5.76e-04	211	97	6	GO:0016758
GeneOntologyMolecularFunction	glucuronosyltransferase activity	UGT2B15 UGT2B17 UGT2B11	6.50e-04	35	97	3	GO:0015020
GeneOntologyMolecularFunction	DEAD/H-box RNA helicase binding	SMAD1 SMAD5	8.22e-04	9	97	2	GO:0017151
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	B3GNT7 UGT2B15 UGT2B17 UGT2B11 MGAT5B	9.05e-04	153	97	5	GO:0008194
GeneOntologyBiologicalProcess	biphenyl catabolic process	UGT2B15 UGT2B17 UGT2B11	5.21e-06	8	95	3	GO:0070980
GeneOntologyBiologicalProcess	biphenyl metabolic process	UGT2B15 UGT2B17 UGT2B11	1.11e-05	10	95	3	GO:0018879
GeneOntologyBiologicalProcess	xenobiotic glucuronidation	UGT2B15 UGT2B17 UGT2B11	2.02e-05	12	95	3	GO:0052697
GeneOntologyCellularComponent	GABA-A receptor complex	GABRA1 GABRA3 GABRA4	8.89e-05	19	97	3	GO:1902711
GeneOntologyCellularComponent	GABA receptor complex	GABRA1 GABRA3 GABRA4	1.21e-04	21	97	3	GO:1902710
GeneOntologyCellularComponent	membrane coat	VPS11 SCYL1 VPS16 SEC24D IGF2R	1.36e-04	106	97	5	GO:0030117
GeneOntologyCellularComponent	coated membrane	VPS11 SCYL1 VPS16 SEC24D IGF2R	1.36e-04	106	97	5	GO:0048475
GeneOntologyCellularComponent	CORVET complex	VPS11 VPS16	4.41e-04	7	97	2	GO:0033263
GeneOntologyCellularComponent	heteromeric SMAD protein complex	SMAD1 SMAD5	5.86e-04	8	97	2	GO:0071144
GeneOntologyCellularComponent	nuclear outer membrane	UGT2B15 UGT2B17 UGT2B11	8.45e-04	40	97	3	GO:0005640
GeneOntologyCellularComponent	SMAD protein complex	SMAD1 SMAD5	9.36e-04	10	97	2	GO:0071141
GeneOntologyCellularComponent	coated vesicle	VPS11 SCYL1 VPS16 PHETA2 SEC24D IGF2R SEC16A	1.44e-03	360	97	7	GO:0030135
GeneOntologyCellularComponent	AP-3 adaptor complex	VPS11 VPS16	1.61e-03	13	97	2	GO:0030123
GeneOntologyCellularComponent	cytoplasmic side of plasma membrane	TRAF1 PTEN TYK2 DLG1 DLG4	1.72e-03	185	97	5	GO:0009898
GeneOntologyCellularComponent	neuromuscular junction	ANK3 LAMA4 DLG1 DLG4	1.85e-03	112	97	4	GO:0031594
GeneOntologyCellularComponent	HOPS complex	VPS11 VPS16	1.87e-03	14	97	2	GO:0030897
Domain	GABAAa_rcpt	GABRA1 GABRA3 GABRA4	2.52e-06	6	95	3	IPR001390
Domain	MAGUK_N_PEST	DLG1 DLG4	1.53e-04	4	95	2	PF10608
Domain	PDZ_assoc	DLG1 DLG4	1.53e-04	4	95	2	PF10600
Domain	DLG1_PEST_dom	DLG1 DLG4	1.53e-04	4	95	2	IPR019590
Domain	PDZ_assoc	DLG1 DLG4	1.53e-04	4	95	2	IPR019583
Domain	MAGUK_N_PEST	DLG1 DLG4	1.53e-04	4	95	2	SM01277
Domain	DLG1	DLG1 DLG4	1.53e-04	4	95	2	IPR016313
Domain	UDPGT	UGT2B15 UGT2B17 UGT2B11	1.59e-04	21	95	3	PF00201
Domain	UDPGT	UGT2B15 UGT2B17 UGT2B11	1.59e-04	21	95	3	PS00375
Domain	UDP_glucos_trans	UGT2B15 UGT2B17 UGT2B11	1.59e-04	21	95	3	IPR002213
Domain	GABAA/Glycine_rcpt	GABRA1 GABRA3 GABRA4	2.10e-04	23	95	3	IPR006028
Domain	DWB	SMAD1 SMAD5	7.03e-04	8	95	2	SM00524
Domain	MH2	SMAD1 SMAD5	7.03e-04	8	95	2	PS51076
Domain	MH1	SMAD1 SMAD5	7.03e-04	8	95	2	PS51075
Domain	-	SMAD1 SMAD5	7.03e-04	8	95	2	3.90.520.10
Domain	MAD_homology_MH1	SMAD1 SMAD5	7.03e-04	8	95	2	IPR013019
Domain	Dwarfin	SMAD1 SMAD5	7.03e-04	8	95	2	IPR013790
Domain	MH2	SMAD1 SMAD5	7.03e-04	8	95	2	PF03166
Domain	SMAD_dom_Dwarfin-type	SMAD1 SMAD5	7.03e-04	8	95	2	IPR001132
Domain	Fol_N	SLIT2 FCGBP	1.37e-03	11	95	2	IPR003645
Domain	FOLN	SLIT2 FCGBP	1.37e-03	11	95	2	SM00274
Domain	Neurotransmitter_ion_chnl_CS	GABRA1 GABRA3 GABRA4	1.55e-03	45	95	3	IPR018000
Domain	MAD_homology1_Dwarfin-type	SMAD1 SMAD5	1.63e-03	12	95	2	IPR003619
Domain	DWA	SMAD1 SMAD5	1.63e-03	12	95	2	SM00523
Domain	C8	FCGBP MUC5AC	1.63e-03	12	95	2	PF08742
Domain	TIL	FCGBP MUC5AC	1.63e-03	12	95	2	PF01826
Domain	MH1	SMAD1 SMAD5	1.63e-03	12	95	2	PF03165
Domain	Neur_chan_memb	GABRA1 GABRA3 GABRA4	1.65e-03	46	95	3	PF02932
Domain	Neurotrans-gated_channel_TM	GABRA1 GABRA3 GABRA4	1.76e-03	47	95	3	IPR006029
Domain	-	GABRA1 GABRA3 GABRA4	1.76e-03	47	95	3	2.70.170.10
Domain	Neur_chan_LBD	GABRA1 GABRA3 GABRA4	1.76e-03	47	95	3	PF02931
Domain	NEUROTR_ION_CHANNEL	GABRA1 GABRA3 GABRA4	1.76e-03	47	95	3	PS00236
Domain	Neur_channel	GABRA1 GABRA3 GABRA4	1.76e-03	47	95	3	IPR006201
Domain	Neur_chan_lig-bd	GABRA1 GABRA3 GABRA4	1.76e-03	47	95	3	IPR006202
Domain	Unchr_dom_Cys-rich	FCGBP MUC5AC	1.93e-03	13	95	2	IPR014853
Domain	C8	FCGBP MUC5AC	1.93e-03	13	95	2	SM00832
Domain	TIL_dom	FCGBP MUC5AC	2.24e-03	14	95	2	IPR002919
Domain	Sushi	SUSD3 CR1 F13B	2.35e-03	52	95	3	PF00084
Domain	CCP	SUSD3 CR1 F13B	2.62e-03	54	95	3	SM00032
Domain	SUSHI	SUSD3 CR1 F13B	2.91e-03	56	95	3	PS50923
Domain	Guanylate_kinase_CS	DLG1 DLG4	2.93e-03	16	95	2	IPR020590
Domain	VWF_type-D	FCGBP MUC5AC	2.93e-03	16	95	2	IPR001846
Domain	VWFD	FCGBP MUC5AC	2.93e-03	16	95	2	PS51233
Domain	SMAD_dom-like	SMAD1 SMAD5	2.93e-03	16	95	2	IPR017855
Domain	-	SMAD1 SMAD5	2.93e-03	16	95	2	2.60.200.10
Domain	VWD	FCGBP MUC5AC	2.93e-03	16	95	2	SM00216
Domain	VWD	FCGBP MUC5AC	2.93e-03	16	95	2	PF00094
Domain	Sushi_SCR_CCP_dom	SUSD3 CR1 F13B	3.06e-03	57	95	3	IPR000436
Domain	CTCK_1	SLIT2 MUC5AC	3.71e-03	18	95	2	PS01185
Domain	WD40_repeat_dom	VPS11 BCAS3 DENND3 RPTOR PAN2 CORO7	4.09e-03	297	95	6	IPR017986
Domain	VWC_out	FCGBP MUC5AC	4.14e-03	19	95	2	SM00215
Domain	RasGEFN	RGL1 RASGRP3	4.58e-03	20	95	2	SM00229
Domain	PWWP	MSH6 DNMT3B	4.58e-03	20	95	2	SM00293
Domain	RasGEF_N	RGL1 RASGRP3	5.05e-03	21	95	2	PF00618
Pathway	BIOCARTA_FLUMAZENIL_PATHWAY	GABRA1 GABRA3 GABRA4	1.24e-05	9	76	3	M22034
Pathway	BIOCARTA_GABA_PATHWAY	GABRA1 GABRA3 GABRA4	1.76e-05	10	76	3	M477
Pathway	BIOCARTA_GABA_PATHWAY	GABRA1 GABRA3 GABRA4	1.76e-05	10	76	3	MM1401
Pathway	WP_EFFECT_OF_OMEGA3_PUFA_ON_HUNTINGTONS_DISEASE_PATHWAYS	PTEN RAB3GAP1 RPTOR GABRA1 GABRA3 GABRA4	4.31e-05	119	76	6	M48309
Pathway	WP_MBDNF_AND_PROBDNF_REGULATION_OF_GABA_NEUROTRANSMISSION	PTEN GABRA1 GABRA3 GABRA4	5.01e-05	38	76	4	M39854
Pathway	KEGG_STARCH_AND_SUCROSE_METABOLISM	AGL UGT2B15 UGT2B17 UGT2B11	1.74e-04	52	76	4	M14171
Pathway	REACTOME_PREDNISONE_ADME	UGT2B15 UGT2B17 UGT2B11	2.47e-04	23	76	3	MM16639
Pathway	BIOCARTA_CTCF_PATHWAY	PTEN SMAD1 SMAD5	2.81e-04	24	76	3	M11420
Pathway	BIOCARTA_CTCF_PATHWAY	PTEN SMAD1 SMAD5	2.81e-04	24	76	3	MM1373
Pathway	REACTOME_GLUCURONIDATION	UGT2B15 UGT2B17 UGT2B11	2.81e-04	24	76	3	MM14599
Pathway	REACTOME_GLUCURONIDATION	UGT2B15 UGT2B17 UGT2B11	3.18e-04	25	76	3	M17787
Pathway	WP_GLUCURONIDATION	UGT2B15 UGT2B17 UGT2B11	3.18e-04	25	76	3	MM15820
Pathway	KEGG_ASCORBATE_AND_ALDARATE_METABOLISM	UGT2B15 UGT2B17 UGT2B11	3.18e-04	25	76	3	M605
Pathway	WP_GLUCURONIDATION	UGT2B15 UGT2B17 UGT2B11	3.58e-04	26	76	3	M39404
Pathway	KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	UGT2B15 UGT2B17 UGT2B11	4.48e-04	28	76	3	M19580
Pathway	REACTOME_NRCAM_INTERACTIONS	DLG1 DLG4	5.92e-04	7	76	2	M27378
Pathway	KEGG_MEDICUS_REFERENCE_BMP15_SIGNALING_PATHWAY	SMAD1 SMAD5	5.92e-04	7	76	2	M47845
Pathway	WP_GABA_RECEPTOR_SIGNALING	GABRA1 GABRA3 GABRA4	6.07e-04	31	76	3	M39369
Pathway	KEGG_MEDICUS_REFERENCE_MYOSTATIN_SIGNALING_PATHWAY	SMAD1 SMAD5	7.86e-04	8	76	2	M47847
Pathway	WP_ADHD_AND_AUTISM_ASD_PATHWAYS	PTEN CBR1 RPTOR DLG1 DLG4 GABRA1 GABRA3 GABRA4	7.88e-04	367	76	8	M48346
Pathway	KEGG_MEDICUS_REFERENCE_AMH_SIGNALING_PATHWAY	SMAD1 SMAD5	1.01e-03	9	76	2	M47844
Pathway	KEGG_MEDICUS_REFERENCE_BMP9_10_SIGNALING_PATHWAY	SMAD1 SMAD5	1.01e-03	9	76	2	M47822
Pathway	KEGG_MEDICUS_PATHOGEN_SALMONELLA_SIFA_TO_TETHERING_OF_LATE_ENDOSOMES_AND_LYSOSOMES	VPS11 VPS16	1.01e-03	9	76	2	M47777
Pathway	REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION	DLG1 DLG4 GABRA1 GABRA3 GABRA4	1.07e-03	144	76	5	MM14501
Pathway	REACTOME_PARACETAMOL_ADME	UGT2B15 UGT2B17 UGT2B11	1.20e-03	39	76	3	MM15695
Pathway	KEGG_MEDICUS_REFERENCE_TETHERING_OF_LATE_ENDOSOMES_AND_LYSOSOMES	VPS11 VPS16	1.26e-03	10	76	2	M47776
Pathway	REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS	DLG1 DLG4	1.26e-03	10	76	2	M10272
Pubmed	Early growth response 1 (Egr-1) directly regulates GABAA receptor α2, α4, and θ subunits in the hippocampus.	DLG4 GABRA1 GABRA3 GABRA4	3.28e-07	21	97	4	25708312
Pubmed	GABAA receptor signaling in caudal periaqueductal gray regulates maternal aggression and maternal care in mice.	GABRA1 GABRA3 GABRA4	4.18e-07	6	97	3	20457185
Pubmed	Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development.	UGT2B15 UGT2B17 UGT2B11	7.30e-07	7	97	3	26074487
Pubmed	Functional proteomics mapping of a human signaling pathway.	FLNA ANK3 IRF2BP1 LAMA4 PRDM4 GGA3 SEC24D KHDRBS1 ASCC3 SMAD1 SMAD5	8.27e-07	591	97	11	15231748
Pubmed	Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.	UGT2B15 UGT2B17 UGT2B11	1.17e-06	8	97	3	32093886
Pubmed	gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties.	GABRA1 GABRA3 GABRA4	1.17e-06	8	97	3	8175718
Pubmed	AnkG hemizygous mice present cognitive impairment and elevated anxiety/depressive-like traits associated with decreased expression of GABA receptors and postsynaptic density protein.	ANK3 DLG4 GABRA1	1.17e-06	8	97	3	28821923
Pubmed	Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation.	GABRA1 GABRA3 GABRA4	1.17e-06	8	97	3	18185516
Pubmed	Functional modifications of acid-sensing ion channels by ligand-gated chloride channels.	GABRA1 GABRA3 GABRA4	2.49e-06	10	97	3	21789198
Pubmed	Review: Central non-glucocorticoid inhibitors of the hypothalamo-pituitary-adrenal axis.	GABRA1 GABRA3 GABRA4	3.41e-06	11	97	3	9924185
Pubmed	Region and layer-specific expression of GABAA receptor isoforms and KCC2 in developing cortex.	GABRA1 GABRA3 GABRA4	3.41e-06	11	97	3	38894703
Pubmed	Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice.	GABRA1 GABRA3 GABRA4	5.89e-06	13	97	3	22569571
Pubmed	Involvement of neurotransmitters in the action of growth hormone-releasing hormone antagonist on passive avoidance learning.	GABRA1 GABRA3 GABRA4	5.89e-06	13	97	3	22640814
Pubmed	The biochemical anatomy of cortical inhibitory synapses.	GABRA1 GABRA3 GABRA4	7.49e-06	14	97	3	22768092
Pubmed	Expression of the BMP receptor Alk3 in the second heart field is essential for development of the dorsal mesenchymal protrusion and atrioventricular septation.	FLNA SMAD1 SMAD5	7.49e-06	14	97	3	23584254
Pubmed	The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A.	FLNA PTEN DLG4	7.49e-06	14	97	3	26972007
Pubmed	Expression of UDP Glucuronosyltransferases 2B15 and 2B17 is associated with methylation status in prostate cancer cells.	UGT2B15 UGT2B17	7.70e-06	2	97	2	32660355
Pubmed	USP52 inhibits cell proliferation by stabilizing PTEN protein in non-small cell lung cancer.	PTEN PAN2	7.70e-06	2	97	2	34533198
Pubmed	BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells.	SMAD1 SMAD5	7.70e-06	2	97	2	26711875
Pubmed	The transcriptional role of Smads and FAST (FoxH1) in TGFbeta and activin signalling.	SMAD1 SMAD5	7.70e-06	2	97	2	11451566
Pubmed	The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence.	UGT2B15 UGT2B17	7.70e-06	2	97	2	1909870
Pubmed	Androgen glucuronidation: an unexpected target for androgen deprivation therapy, with prognosis and diagnostic implications.	UGT2B15 UGT2B17	7.70e-06	2	97	2	24121496
Pubmed	Novel associations of UDP-glucuronosyltransferase 2B gene variants with prostate cancer risk in a multiethnic study.	UGT2B15 UGT2B17	7.70e-06	2	97	2	24267955
Pubmed	Differential expression of the androgen-conjugating UGT2B15 and UGT2B17 enzymes in prostate tumor cells during cancer progression.	UGT2B15 UGT2B17	7.70e-06	2	97	2	22170718
Pubmed	BMP-SMAD1/5 Signaling Regulates Retinal Vascular Development.	SMAD1 SMAD5	7.70e-06	2	97	2	32210087
Pubmed	Localization of UDP glucuronosyltransferase gene(s) on mouse chromosome 5.	UGT2B15 UGT2B17	7.70e-06	2	97	2	3105095
Pubmed	UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells.	UGT2B15 UGT2B17	7.70e-06	2	97	2	17848572
Pubmed	Interaction between SAP97 and PSD-95, two Maguk proteins involved in synaptic trafficking of AMPA receptors.	DLG1 DLG4	7.70e-06	2	97	2	16332687
Pubmed	BMP receptor-integrin interaction mediates responses of vascular endothelial Smad1/5 and proliferation to disturbed flow.	SMAD1 SMAD5	7.70e-06	2	97	2	23387849
Pubmed	Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17.	UGT2B15 UGT2B17	7.70e-06	2	97	2	27496708
Pubmed	Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location.	OR4F4 OR4F17	7.70e-06	2	97	2	11689484
Pubmed	Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes.	OR4F4 OR4F17	7.70e-06	2	97	2	11689483
Pubmed	Maintenance of recombinant type A gamma-aminobutyric acid receptor function: role of protein tyrosine phosphorylation and calcineurin.	GABRA1 GABRA3	7.70e-06	2	97	2	9655866
Pubmed	Disruption of mTORC1 rescues neuronal overgrowth and synapse function dysregulated by Pten loss.	PTEN RPTOR	7.70e-06	2	97	2	36323257
Pubmed	Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.	SMAD1 SMAD5	7.70e-06	2	97	2	8799132
Pubmed	The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17 deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men.	UGT2B15 UGT2B17	7.70e-06	2	97	2	17698910
Pubmed	BMP signaling dynamics in embryonic orofacial tissue.	SMAD1 SMAD5	7.70e-06	2	97	2	18446813
Pubmed	Effect of localization, length and orientation of chondrocytic primary cilium on murine growth plate organization.	SMAD1 SMAD5	7.70e-06	2	97	2	21723296
Pubmed	Regulation of the levels of Smad1 and Smad5 in MC3T3-E1 cells by Icariine in vitro.	SMAD1 SMAD5	7.70e-06	2	97	2	24297369
Pubmed	The role of FilGAP-filamin A interactions in mechanoprotection.	FLNA ARHGAP24	7.70e-06	2	97	2	19144823
Pubmed	GABAA receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processes.	GABRA1 DNMT3B	7.70e-06	2	97	2	18639864
Pubmed	Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism.	GGA3 IGF2R	7.70e-06	2	97	2	12032548
Pubmed	Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome.	GABRA1 GABRA3	7.70e-06	2	97	2	23744069
Pubmed	MicroRNA-21 orchestrates high glucose-induced signals to TOR complex 1, resulting in renal cell pathology in diabetes.	PTEN RPTOR	7.70e-06	2	97	2	21613227
Pubmed	Mouse UDP glucuronosyltransferase. cDNA and complete amino acid sequence and regulation.	UGT2B15 UGT2B17	7.70e-06	2	97	2	3117546
Pubmed	Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations.	FLNA ARHGAP24	7.70e-06	2	97	2	19293932
Pubmed	Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation.	UGT2B15 UGT2B17	7.70e-06	2	97	2	28228532
Pubmed	Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium.	UGT2B15 UGT2B17	7.70e-06	2	97	2	15666817
Pubmed	Filamin associates with Smads and regulates transforming growth factor-beta signaling.	FLNA SMAD5	7.70e-06	2	97	2	11278410
Pubmed	Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor.	SEC24D SEC16A SMARCB1 KLHL26	1.19e-05	50	97	4	27716508
Pubmed	mTOR deletion in neural crest cells disrupts cardiac outflow tract remodeling and causes a spectrum of cardiac defects through the mTORC1 pathway.	RPTOR SMAD1 SMAD5	1.39e-05	17	97	3	34052210
Pubmed	Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.	GABRA1 GABRA3 GABRA4	1.66e-05	18	97	3	19078961
Pubmed	GABA neurotransmitter signaling in the developing mouse lens: dynamic regulation of components and functionality.	GABRA1 GABRA3 GABRA4	1.66e-05	18	97	3	18985723
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	ANK3 FNBP1L DLG1 DLG4 GABRA1 GABRA3	1.97e-05	197	97	6	36604605
Pubmed	Homeodomain interacting protein kinase 2 regulates postnatal development of enteric dopaminergic neurons and glia via BMP signaling.	DLG4 SMAD1 SMAD5	1.97e-05	19	97	3	21957238
Pubmed	ROBO2 restricts the nephrogenic field and regulates Wolffian duct-nephrogenic cord separation.	SLIT2 SMAD1 SMAD5	1.97e-05	19	97	3	26116176
Pubmed	Non-canonical cyclic AMP SMAD1/5/8 signalling in human granulosa cells.	SMAD1 SMAD5	2.31e-05	3	97	2	30953749
Pubmed	Copy-number variations (CNVs) of the human sex steroid metabolizing genes UGT2B17 and UGT2B28 and their associations with a UGT2B15 functional polymorphism.	UGT2B15 UGT2B17	2.31e-05	3	97	2	19572376
Pubmed	Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation.	SMAD1 SMAD5	2.31e-05	3	97	2	32720893
Pubmed	Investigation of autism and GABA receptor subunit genes in multiple ethnic groups.	GABRA1 GABRA4	2.31e-05	3	97	2	16770606
Pubmed	Direct visualization of Smad1/5/8-mediated transcriptional activity identifies podocytes and collecting ducts as major targets of BMP signalling in healthy and diseased kidneys.	SMAD1 SMAD5	2.31e-05	3	97	2	21381028
Pubmed	Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding.	PTEN DLG1	2.31e-05	3	97	2	10646847
Pubmed	Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture.	SMAD1 SMAD5	2.31e-05	3	97	2	20371744
Pubmed	Clustering and enhanced activity of an inwardly rectifying potassium channel, Kir4.1, by an anchoring protein, PSD-95/SAP90.	DLG1 DLG4	2.31e-05	3	97	2	9148889
Pubmed	Epigenetic regulation of steroid inactivating UDP-glucuronosyltransferases by microRNAs in prostate cancer.	UGT2B15 UGT2B17	2.31e-05	3	97	2	26385605
Pubmed	TGF-β1, but not bone morphogenetic proteins, activates Smad1/5 pathway in primary human macrophages and induces expression of proatherogenic genes.	SMAD1 SMAD5	2.31e-05	3	97	2	25505291
Pubmed	Fluoride promotes viability and differentiation of osteoblast-like Saos-2 cells via BMP/Smads signaling pathway.	SMAD1 SMAD5	2.31e-05	3	97	2	23918166
Pubmed	Smad1 and 5 but not Smad8 establish stem cell quiescence which is critical to transform the premature hair follicle during morphogenesis toward the postnatal state.	SMAD1 SMAD5	2.31e-05	3	97	2	24023003
Pubmed	Higher methylation intensity induced by EBV LMP1 via NF-κB/DNMT3b signaling contributes to silencing of PTEN gene.	PTEN DNMT3B	2.31e-05	3	97	2	27223069
Pubmed	GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes.	DLG1 DLG4	2.31e-05	3	97	2	10859302
Pubmed	A specific N-terminal residue in Kv1.5 is required for upregulation of the channel by SAP97.	DLG1 DLG4	2.31e-05	3	97	2	16466689
Pubmed	Ablation of Hepatocyte Smad1, Smad5, and Smad8 Causes Severe Tissue Iron Loading and Liver Fibrosis in Mice.	SMAD1 SMAD5	2.31e-05	3	97	2	31127639
Pubmed	TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch.	SMAD1 SMAD5	2.31e-05	3	97	2	19096363
Pubmed	FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling.	FLNA ARHGAP24	2.31e-05	3	97	2	16862148
Pubmed	BMP9 promotes cutaneous wound healing by activating Smad1/5 signaling pathways and cytoskeleton remodeling.	SMAD1 SMAD5	2.31e-05	3	97	2	33463047
Pubmed	A functional network of the tumor suppressors APC, hDlg, and PTEN, that relies on recognition of specific PDZ-domains.	PTEN DLG1	2.31e-05	3	97	2	22434720
Pubmed	Erbin plays a critical role in human umbilical vein endothelial cell migration and tubular structure formation via the Smad1/5 pathway.	SMAD1 SMAD5	2.31e-05	3	97	2	30367512
Pubmed	Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions.	PTEN DLG1	2.31e-05	3	97	2	11439092
Pubmed	Differential Expression and Clinical Significance of DNA Methyltransferase 3B (DNMT3B), Phosphatase and Tensin Homolog (PTEN) and Human MutL Homologs 1 (hMLH1) in Endometrial Carcinomas.	PTEN DNMT3B	2.31e-05	3	97	2	28220037
Pubmed	Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.	FLNA ARHGAP24	2.31e-05	3	97	2	21926999
Pubmed	Long-term culture and significant expansion of human Sertoli cells whilst maintaining stable global phenotype and AKT and SMAD1/5 activation.	SMAD1 SMAD5	2.31e-05	3	97	2	25880873
Pubmed	Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus.	GABRA1 GABRA4	2.31e-05	3	97	2	24027285
Pubmed	Specific GABAA circuits for visual cortical plasticity.	GABRA1 GABRA3	2.31e-05	3	97	2	15017002
Pubmed	Bone morphogenetic protein 2 stimulation of tumor growth involves the activation of Smad-1/5.	SMAD1 SMAD5	2.31e-05	3	97	2	16247476
Pubmed	Smad and AML proteins synergistically confer transforming growth factor beta1 responsiveness to human germ-line IgA genes.	SMAD1 SMAD5	2.31e-05	3	97	2	10652350
Pubmed	Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons.	GABRA1 GABRA3	2.31e-05	3	97	2	16835366
Pubmed	TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition.	SMAD1 SMAD5	2.31e-05	3	97	2	29376829
Pubmed	HOTAIR suppresses PTEN via DNMT3b and confers drug resistance in acute myeloid leukemia.	PTEN DNMT3B	2.31e-05	3	97	2	33538241
Pubmed	Regulation of Human UGT2B15 and UGT2B17 by miR-376c in Prostate Cancer Cell Lines.	UGT2B15 UGT2B17	2.31e-05	3	97	2	26163549
Pubmed	Forkhead box protein A1 regulates UDP-glucuronosyltransferase 2B15 gene transcription in LNCaP prostate cancer cells.	UGT2B15 UGT2B17	2.31e-05	3	97	2	20736324
Pubmed	The cytoplasmic domain of NrCAM binds to PDZ domains of synapse-associated proteins SAP90/PSD95 and SAP97.	DLG1 DLG4	2.31e-05	3	97	2	16882004
Pubmed	BMP signaling initiates a neural crest differentiation program in embryonic rat CNS stem cells.	SMAD1 SMAD5	2.31e-05	3	97	2	15246821
Pubmed	Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex.	DLG1 DLG4	2.31e-05	3	97	2	10939335
Pubmed	Identification and validation of mRNA 3'untranslated regions of DNMT3B and TET3 as novel competing endogenous RNAs of the tumor suppressor PTEN.	PTEN DNMT3B	2.31e-05	3	97	2	31894272
Pubmed	BMP-specific SMADs function as novel repressors of PDGFA and modulate its expression in ovarian granulosa cells and tumors.	SMAD1 SMAD5	2.31e-05	3	97	2	22964636
Pubmed	Genetic variations in UGT2B28, UGT2B17, UGT2B15 genes and the risk of prostate cancer: A case-control study.	UGT2B15 UGT2B17	2.31e-05	3	97	2	28882566
Pubmed	Analysis of the presence and abundance of GABAA receptors containing two different types of alpha subunits in murine brain using point-mutated alpha subunits.	GABRA1 GABRA3	2.31e-05	3	97	2	15304513
Pubmed	Differential expression of TGF-β superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation.	SMAD1 SMAD5	2.31e-05	3	97	2	27848974
Pubmed	Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.	SMAD1 SMAD5	2.31e-05	3	97	2	20522807
Pubmed	Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes and areas of chromosomal loss involving CDKN2A, PTEN, and SMARCB1.	PTEN SMARCB1	2.31e-05	3	97	2	24983247
GeneFamily	Gamma-aminobutyric acid type A receptor subunits	GABRA1 GABRA3 GABRA4	5.61e-05	19	72	3	563
GeneFamily	UDP glucuronosyltransferases	UGT2B15 UGT2B17 UGT2B11	2.76e-04	32	72	3	363
GeneFamily	SMAD family	SMAD1 SMAD5	4.31e-04	8	72	2	750
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SUSD3 CR1 F13B	1.52e-03	57	72	3	1179
GeneFamily	PWWP domain containing	MSH6 DNMT3B	3.43e-03	22	72	2	1147
Coexpression	GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_60H_DN	POLR1A ANK3 BCAS3 PSMD5 AGL DLG4 GABRA1	9.10e-06	200	96	7	M9657
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#4_top-relative-expression-ranked_1000	ANK3 BCAS3 LAMA4 GATA5 CEP350 RGL1 RPTOR ASCC3 SMAD5 GABRA3	5.95e-06	385	91	10	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000_k4
CoexpressionAtlas	DevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#5_top-relative-expression-ranked_1000	ARHGAP24 ANK3 BIVM ZBTB41 PTEN CEP350 ASCC3 SMAD5 DNMT3B	1.50e-05	339	91	9	gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_1000_k5
ToppCell	mLN-(2)_B_cell-(22)_B_cell_memory\|mLN / shred on region, Cell_type, and subtype	ARHGAP24 CR1 PRDM4 ST14 DENND3 SMARCB1	4.77e-06	198	97	6	4d189df1db5b41306e9653436d7d7e75ff5afa06
ToppCell	mLN-B_cell-B_cell_memory\|mLN / Region, Cell class and subclass	ARHGAP24 CR1 PRDM4 ST14 DENND3 SMARCB1	4.77e-06	198	97	6	6dc155ee487abb1319a60a7a70e84c28c9851985
ToppCell	facs-Trachea-nan-18m-Myeloid-lymphocyte_of_B_lineage\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRAF1 OVCH2 GGA3 RASGRP3 CDT1	2.64e-05	160	97	5	5c9281706009558c8361bfa76169f43ffc0f7947
ToppCell	facs-Trachea-18m-Hematologic-lymphocytic-B_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TRAF1 OVCH2 GGA3 RASGRP3 CDT1	2.98e-05	164	97	5	4274a4f225cabf61f0fe27d8ea162b4eba612f87
ToppCell	facs-Trachea-18m-Hematologic-lymphocytic-B_cell-B_cell_of_the_trachea\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TRAF1 OVCH2 GGA3 RASGRP3 CDT1	2.98e-05	164	97	5	d62143450f59097ad4b34603a6257f897a769ead
ToppCell	3'_v3-blood-Mast-Mast_cells\|blood / Manually curated celltypes from each tissue	BIVM FNBP1L UGT2B11 SMAD5 DNMT3B	4.17e-05	176	97	5	b9da3deaf62622d47eb30b6be7548253eee95597
ToppCell	3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMA4 PTPN21 CBR1 ST14 PDE11A	4.28e-05	177	97	5	6d89042bda8e244babb68929e84b25edcb545a77
ToppCell	3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMA4 PTPN21 CBR1 ST14 PDE11A	4.28e-05	177	97	5	daaccf1249dcf816df4caca695a944f53078291a
ToppCell	3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMA4 PTPN21 CBR1 ST14 PDE11A	4.28e-05	177	97	5	338bdda26796bf4e16072878c070212d1006cf57
ToppCell	3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMA4 PTPN21 CBR1 ST14 PDE11A	4.28e-05	177	97	5	c5a16f984c836dbf7d0faf061677844167ab612a
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LAMA4 TRIM54 FNBP1L ASIC5 MGAT5B	4.40e-05	178	97	5	731e1e8eff2c4018c75dfc66632a316010a09a9a
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POLR1A BIVM FNBP1L GGA3 RASGRP3	4.64e-05	180	97	5	be10fe5bf7c3a671c42704ce7dd8226ab6896794
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POLR1A BIVM FNBP1L GGA3 RASGRP3	4.64e-05	180	97	5	3b747a517ce75ef2ff09011c037dad7b01ed3e03
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ALKAL1 PTPN21 CBR1 ST14 PDE11A	4.76e-05	181	97	5	40df0afcb6848202da54670e84f22d7c3a515d01
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ALKAL1 PTPN21 CBR1 ST14 PDE11A	4.76e-05	181	97	5	2b53a65ca5616a7b9f64232c3e0b7212d1e2f063
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ALKAL1 PTPN21 CBR1 ST14 PDE11A	4.76e-05	181	97	5	6aef84616e8d2faf54b7e9e6cd02f33c3066dabc
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ALKAL1 PTPN21 CBR1 ST14 PDE11A	4.76e-05	181	97	5	40d3829ae4aaf81e8616c3499ff8933137fc1cc4
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMA4 KLF15 GATA5 SLIT2 GABRA3	5.28e-05	185	97	5	355b03c7ea438681e11a2b872c798c9ea26e1486
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANK3 CFAP65 FCGBP EFCAB12 MUC5AC	5.99e-05	190	97	5	2fdc024d3d673a0134b74b4c5a63afe924995730
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	ANK3 ACO2 OBSCN TRIM54 RASGRP3	6.15e-05	191	97	5	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMA4 KLF15 TMEM132C SLIT2 GABRA3	6.15e-05	191	97	5	cd497abed9e00e4e0becd9dbc036c6e7a60ae791
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	G2E3 ZBTB41 CEP350 IGF2R DLG1	6.46e-05	193	97	5	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	COPD-Endothelial-Lymphatic\|Endothelial / Disease state, Lineage and Cell class	LAMA4 B3GNT7 RASGRP3 DLG1 SMAD1	6.78e-05	195	97	5	e91ce548ae7224661ee5d2f2639794a5f69798ee
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	LAMA4 GATA5 TMEM132C SLIT2 ASPA	6.78e-05	195	97	5	1cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ARHGAP24 CR1 PRDM4 DENND3 RASGRP3	7.11e-05	197	97	5	fa3cc33c975648172feabb485c3bdd087f1f8ea7
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	ACO2 B3GNT7 CEP350 KHDRBS1 SMAD5	7.46e-05	199	97	5	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	mild-B_memory\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ARHGAP24 CR1 RASGRP3 SMARCB1 UGT2B17	7.46e-05	199	97	5	025bb65629d9e20c374e8f1ba08c36d1bb569190
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	FLNA ALKAL1 ANK3 LAMA4 TMEM132C	7.64e-05	200	97	5	09537dc25f8b8b4654a7c183827ee1522a41a4e0
Drug	Lorazepam	GABRA1 GABRA3 GABRA4	6.99e-07	5	95	3	ctd:D008140
Drug	Meprobamate	GABRA1 GABRA3 GABRA4	1.39e-06	6	95	3	DB00371
Drug	oxazepam	UGT2B15 UGT2B17 UGT2B11 GABRA1 GABRA4	2.79e-06	53	95	5	CID000004616
Drug	Ethchlorvynol	GABRA1 GABRA3 GABRA4	5.80e-06	9	95	3	DB00189
Drug	Secobarbital	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB00418
Drug	Chlordiazepoxide	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB00475
Drug	Metharbital	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB00463
Drug	Pentobarbital	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB00312
Drug	Talbutal	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB00306
Drug	Clobazam	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB00349
Drug	Butalbital	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB00241
Drug	Butabarbital	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB00237
Drug	Bromazepam	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB01558
Drug	Barbituric acid derivative	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB01496
Drug	Barbital	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB01483
Drug	Hexobarbital	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB01355
Drug	Aprobarbital	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB01352
Drug	Amobarbital	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB01351
Drug	Heptabarbital	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB01354
Drug	Butethal	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB01353
Drug	Clonazepam	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB01068
Drug	Methylphenobarbital	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB00849
Drug	Oxazepam	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB00842
Drug	Primidone	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB00794
Drug	Midazolam	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB00683
Drug	Flurazepam	GABRA1 GABRA3 GABRA4	8.27e-06	10	95	3	DB00690
Drug	Thiopental	GABRA1 GABRA3 GABRA4	1.13e-05	11	95	3	DB00599
Drug	Alprazolam	GABRA1 GABRA3 GABRA4	1.13e-05	11	95	3	DB00404
Drug	Temazepam	GABRA1 GABRA3 GABRA4	1.13e-05	11	95	3	DB00231
Drug	Nitrazepam	GABRA1 GABRA3 GABRA4	1.13e-05	11	95	3	DB01595
Drug	Lorazepam	GABRA1 GABRA3 GABRA4	1.13e-05	11	95	3	DB00186
Drug	Phenobarbital	GABRA1 GABRA3 GABRA4	1.13e-05	11	95	3	DB01174
Drug	Triazolam	GABRA1 GABRA3 GABRA4	1.13e-05	11	95	3	DB00897
Drug	Clorazepate	GABRA1 GABRA3 GABRA4	1.13e-05	11	95	3	DB00628
Drug	hexobarbital	UGT2B15 UGT2B17 CYP2U1 UGT2B11 GABRA1 GABRA4	1.55e-05	127	95	6	CID000003608
Drug	DMCM	CBR1 GABRA1 GABRA3 GABRA4	1.88e-05	38	95	4	CID000104999
Drug	pinazepam	PROZ GABRA1 GABRA4	3.09e-05	15	95	3	CID000040391
Drug	dihydroxyaflavinine	GABRA1 GABRA3 GABRA4	4.59e-05	17	95	3	CID000156857
Drug	Zolpidem	GABRA1 GABRA3	5.15e-05	3	95	2	DB00425
Drug	C1 11-32	UGT2B15 UGT2B17 UGT2B11	5.49e-05	18	95	3	CID000443077
Drug	C11131	UGT2B15 UGT2B17 UGT2B11	5.49e-05	18	95	3	CID000443076
Drug	phenazepam	PROZ GABRA1 GABRA4	5.49e-05	18	95	3	CID000040113
Drug	Finrazole	CBR1 PROZ GABRA1 GABRA4	6.12e-05	51	95	4	CID000178036
Drug	3 -hydroxypregn-5-en-20-one	CBR1 UGT2B15 UGT2B17 CYP2U1 UGT2B11 GABRA1 GABRA4	6.32e-05	238	95	7	CID000001027
Drug	T4-G	UGT2B15 UGT2B17 UGT2B11	6.50e-05	19	95	3	CID000152424
Drug	halazepam	PROZ GABRA1 GABRA4	7.62e-05	20	95	3	CID000031640
Drug	estriol-16-glucuronide	UGT2B15 UGT2B17 UGT2B11	8.86e-05	21	95	3	CID000122281
Drug	prazepam	PROZ GABRA1 GABRA4	8.86e-05	21	95	3	CID000004890
Drug	Flunitrazepam	UGT2B15 GABRA1 GABRA3	8.86e-05	21	95	3	ctd:D005445
Drug	phenobarbital quinidine	GABRA1 GABRA3 GABRA4	1.02e-04	22	95	3	ctd:C033457
Drug	Flumazenil	GABRA1 GABRA3	1.03e-04	4	95	2	DB01205
Drug	flunitrazepam	CBR1 GABRA1 GABRA3 GABRA4	1.09e-04	59	95	4	CID000003380
Drug	ketamine	ASIC5 F13B PROZ DLG4 GABRA1 GABRA3 GABRA4	1.15e-04	262	95	7	CID000003821
Drug	estradiol-3-glucuronide	UGT2B15 UGT2B17 UGT2B11	1.17e-04	23	95	3	CID000066651
Drug	prochloraz	CBR1 IGF2R DLG1 CYP2U1 DLG4 CDT1 GABRA4	1.32e-04	268	95	7	ctd:C045362
Drug	methohexital	GABRA1 GABRA3 GABRA4	1.34e-04	24	95	3	CID000009034
Drug	alpidem	CBR1 GABRA1 GABRA4	1.34e-04	24	95	3	CID000054897
Drug	beta-CCM	CBR1 GABRA1 GABRA4	1.34e-04	24	95	3	CID000107704
Drug	Hymecromone	UGT2B15 UGT2B17 UGT2B11	1.51e-04	25	95	3	ctd:D006923
Drug	Eszopiclone	GABRA1 GABRA3	1.71e-04	5	95	2	DB00402
Drug	Zopiclone	GABRA1 GABRA3	1.71e-04	5	95	2	DB01198
Drug	9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2; Down 200; 10uM; PC3; HT_HG-U133A	BCKDHB DENND3 KHDRBS1 MSL3 ERMAP SMAD5	1.78e-04	197	95	6	7504_DN
Drug	Cyclopentolate hydrochloride [5870-29-1]; Up 200; 12.2uM; MCF7; HT_HG-U133A	IRF2BP1 CR1 DENND3 SLIT2 DLG4 SMAD1	1.78e-04	197	95	6	3555_UP
Drug	morphine hydrochloride	IGF2R ERMAP UGT2B15 UGT2B17 DLG4 UGT2B11 GABRA1 GABRA3 GABRA4	1.83e-04	481	95	9	CID000004253
Drug	Linuron	IGF2R RPTOR DLG1 DLG4 GABRA4	2.01e-04	128	95	5	ctd:D008044
Drug	Menthol	UGT2B15 UGT2B11 GABRA1	2.14e-04	28	95	3	ctd:D008610
Drug	L-idaro-1,4-lactone	UGT2B15 UGT2B17 UGT2B11	2.14e-04	28	95	3	CID000078997
Drug	Citric Acid	ACO2 DLG4 MUC5AC	2.38e-04	29	95	3	ctd:D019343
Drug	7-hydroxycoumarin glucuronide	UGT2B15 UGT2B17 UGT2B11	2.38e-04	29	95	3	CID000125641
Drug	eugenol	SMARCB1 UGT2B15 UGT2B17 UGT2B11	2.48e-04	73	95	4	CID000003314
Drug	Flunitrazepam	GABRA3 GABRA4	2.56e-04	6	95	2	DB01544
Drug	isoborneol	UGT2B15 GABRA1	2.56e-04	6	95	2	ctd:C022871
Drug	lorcaserin	UGT2B15 UGT2B17	2.56e-04	6	95	2	ctd:C506658
Drug	zaleplon	GABRA1 GABRA4	2.56e-04	6	95	2	ctd:C085665
Drug	3-isothujone	GABRA1 GABRA3 GABRA4	2.63e-04	30	95	3	CID000011027
Disease	X-19141 measurement	UGT2B15 UGT2B17 UGT2B11	8.75e-06	13	94	3	EFO_0800799
Disease	Prostatic Neoplasms	TRAF1 KLF15 PTEN CBR1 ST14 IGF2R MAD1L1 UGT2B15 UGT2B17 DNMT3B	2.74e-05	616	94	10	C0033578
Disease	Malignant neoplasm of prostate	TRAF1 KLF15 PTEN CBR1 ST14 IGF2R MAD1L1 UGT2B15 UGT2B17 DNMT3B	2.74e-05	616	94	10	C0376358
Disease	cholic acid glucuronide measurement	UGT2B15 UGT2B17	3.01e-05	3	94	2	EFO_0800574
Disease	X-24947 measurement	UGT2B15 UGT2B17 UGT2B11	4.61e-05	22	94	3	EFO_0800910
Disease	X-25937 measurement	UGT2B15 UGT2B17	6.00e-05	4	94	2	EFO_0800937
Disease	refractive error	ANK3 TDRD9 BCAS3 ACO2 MAD1L1 ECEL1 PDE11A	8.47e-05	326	94	7	MONDO_0004892
Disease	X-24574 measurement	UGT2B15 UGT2B17	2.09e-04	7	94	2	EFO_0800897
Disease	empathy measurement	FNBP1L TMEM132C RPTOR ECEL1 GABRA1	2.17e-04	170	94	5	EFO_0009183
Disease	deoxycholic acid glucuronide measurement	UGT2B15 UGT2B17	2.78e-04	8	94	2	EFO_0800575
Disease	benign neoplasm (implicated_via_orthology)	DLG1 DLG4	2.78e-04	8	94	2	DOID:0060072 (implicated_via_orthology)
Disease	diastolic blood pressure, systolic blood pressure	ANK3 SCYL1 GATA5 PTEN CEP350 RGL1 MSH6 SEC16A PDE11A	2.91e-04	670	94	9	EFO_0006335, EFO_0006336
Disease	plasma clozapine-to-N-desmethylclozapine ratio measurement	UGT2B15 UGT2B11	3.56e-04	9	94	2	EFO_0600040
Disease	Malignant tumor of prostate	PTEN MAD1L1	3.56e-04	9	94	2	cv:C0376358
Disease	4-androsten-3alpha,17alpha-diol monosulfate (3) measurement	UGT2B15 UGT2B17	4.44e-04	10	94	2	EFO_0022090
Disease	Schizophrenia	ANK3 PTPN21 CFAP65 MAD1L1 DLG1 DLG4 GABRA1 SMAD5 GABRA4 DNMT3B	5.12e-04	883	94	10	C0036341
Disease	diet measurement, adiponectin measurement	SLIT2 PDE11A	5.42e-04	11	94	2	EFO_0004502, EFO_0008111
Disease	DNA repair protein RAD51 homolog 4 measurement	UGT2B15 UGT2B17	5.42e-04	11	94	2	EFO_0801531
Disease	5alpha-androstan-3beta,17beta-diol monosulfate (2) measurement	UGT2B15 UGT2B17	6.49e-04	12	94	2	EFO_0800291
Disease	juvenile polyposis syndrome (implicated_via_orthology)	SMAD1 SMAD5	7.65e-04	13	94	2	DOID:0050787 (implicated_via_orthology)
Disease	androstenediol (3alpha, 17alpha) monosulfate (3) measurement	UGT2B15 UGT2B17	7.65e-04	13	94	2	EFO_0800293
Disease	dystonia (is_implicated_in)	VPS11 VPS16	8.91e-04	14	94	2	DOID:543 (is_implicated_in)
Disease	5alpha-androstan-3alpha,17alpha-diol monosulfate measurement	UGT2B15 UGT2B17	8.91e-04	14	94	2	EFO_0800283
Disease	Tremor, Rubral	GABRA1 GABRA4	1.17e-03	16	94	2	C0750940
Disease	Ataxia, Appendicular	GABRA1 GABRA4	1.17e-03	16	94	2	C0750937
Disease	Ataxia, Motor	GABRA1 GABRA4	1.17e-03	16	94	2	C0278161
Disease	lysosomal storage disease (implicated_via_orthology)	VPS16 GGA3	1.17e-03	16	94	2	DOID:3211 (implicated_via_orthology)
Disease	Ataxia, Sensory	GABRA1 GABRA4	1.17e-03	16	94	2	C0240991
Disease	central nervous system disease (implicated_via_orthology)	IRF2BP1 ACO2	1.17e-03	16	94	2	DOID:331 (implicated_via_orthology)
Disease	Abnormal coordination	GABRA1 GABRA4	1.17e-03	16	94	2	C0520966
Disease	Ataxia, Truncal	GABRA1 GABRA4	1.17e-03	16	94	2	C0427190
Disease	Abnormality of refraction	ALKAL1 ANK3 TDRD9 BCAS3 DENND3 MAD1L1 ECEL1 PDE11A	1.40e-03	673	94	8	HP_0000539
Disease	Malignant neoplasm of endometrium	PTEN MSH6	1.49e-03	18	94	2	C0007103
Disease	Carcinoma in situ of endometrium	PTEN MSH6	1.49e-03	18	94	2	C0346191
Disease	5alpha-androstan-3alpha,17beta-diol monosulfate (1) measurement	UGT2B15 UGT2B17	1.49e-03	18	94	2	EFO_0800288
Disease	event free survival time, urinary bladder cancer	G2E3 MAD1L1	1.66e-03	19	94	2	EFO_0000482, MONDO_0001187
Disease	Meningioma	PTEN SMARCB1	1.66e-03	19	94	2	C0025286
Disease	etiocholanolone glucuronide measurement	UGT2B15 UGT2B17	1.66e-03	19	94	2	EFO_0800362
Disease	Adenocarcinoma of prostate	PTEN MAD1L1	1.84e-03	20	94	2	C0007112
Disease	androsterone glucuronide measurement	UGT2B15 UGT2B17	1.84e-03	20	94	2	EFO_0800317
Disease	Mood Disorders	ANK3 DLG4 GABRA1 DNMT3B	2.08e-03	168	94	4	C0525045
Disease	Malignant neoplasm of breast	FLNA ACO2 OBSCN SUSD3 PTEN GGA3 RGL1 MSH6 GABRA4 DNMT3B	2.23e-03	1074	94	10	C0006142
Disease	orofacial cleft, sex interaction measurement	BCAS3 SUSD3 ST14	2.65e-03	86	94	3	EFO_0008343, MONDO_0000358
Disease	Neoplasm of the genitourinary tract	PTEN MAD1L1	2.65e-03	24	94	2	cv:C0042065
Disease	airway responsiveness measurement	BCAS3 RPTOR	2.65e-03	24	94	2	EFO_0006897
Disease	epiandrosterone sulfate measurement	UGT2B15 UGT2B17	2.87e-03	25	94	2	EFO_0021120
Disease	Ataxia	GABRA1 GABRA4	2.87e-03	25	94	2	C0004134
Disease	myeloperoxidase measurement	BCAS3 SMG8	3.10e-03	26	94	2	EFO_0005243

Protein segments in the cluster

Peptide	Gene	Start	Entry
EFKDHLVPDPGCHYD	ACO2	321	Q99798
KNPVSFHPLFEGGLC	DNMT3B	441	Q9UBC3
FIKHFTGPVTFSPEC	ALKAL1	76	Q6UXT8
LISEFPDKFGSCVPH	DLG1	731	Q12959
EPCGEKAPAYQRFHA	CDT1	161	Q9H211
HYFCPIGFEATPVKA	BIVM	326	Q86UB2
KTHRECPGCFVPFAV	DENND3	96	A2RUS2
DGIVAHFPAHEKPVC	BCAS3	341	Q9H6U6
VFDPEPVIAHCFKQF	EFCAB12	31	Q6NXP0
HALEKCIAYSPPFGD	RAVER2	626	Q9HCJ3
KLPFGACEDPISELH	RAB3GAP1	266	Q15042
AEDFREPPHFPCLQK	RGL1	156	Q9NZL6
EAFFAHCPGIKVVIP	BCKDHB	201	P21953
FCEPTGLANPADIFH	PAN2	311	Q504Q3
HFFCDGPPVLKLVTV	OR10A7	176	Q8NGE5
AEHPGDCLIFKATSP	MAD1L1	656	Q9Y6D9
VLPGEKKCVSVFFHP	CFAP65	416	Q6ZU64
EFHEDLFPDTAGCVP	CORO7	351	P57737
DHGLICEPSFFPFLN	MGAT5B	706	Q3V5L5
GELYAEEKPCGFPHV	F13B	16	P05160
KFFDVHAGTPLLPCS	PDE11A	256	Q9HCR9
FHSGEKVLCFEPDPT	MSL3	11	Q8N5Y2
GFRILFHFAKECPPG	GGA3	606	Q9NZ52
EDFPMDVHACPLKFG	GABRA3	196	P34903
EDFPMDAHACPLKFG	GABRA1	171	P14867
LVDFPMDGHACPLKF	GABRA4	176	P48169
LFKDSGHPCTAADPD	FBXO25	336	Q8TCJ0
DADGPFGRCHAAVKP	MUC5AC	636	P98088
AVHLPFCGPNEVDSF	OR4F17	156	Q8NGA8
HPCITKTFFGDDFIP	MSH6	1096	P52701
FEEFGRAFHCPKDSP	ECEL1	751	O95672
PEHGCPEDLKGFLSY	PTPN21	1066	Q16825
KNIIDHFFCDAPPLV	OR9G4	186	Q8NGQ1
VHPAREDIKICDFGF	OBSCN	6596	Q5VST9
EGEECHPGSHKVPFF	PROK1	56	P58294
VPEKYFPGSCDIVGH	PAQR8	266	Q8TEZ7
SEHPCNEENPGKFLF	ARHGAP24	71	Q8N264
QKHGEDPFCPFSIIS	CYP2U1	211	Q7Z449
APGHLEFKFEPEDFA	GATA5	356	Q9BWX5
GFKPTPSIECLHVDF	G2E3	646	Q7L622
DLHFPESFAGIACAP	KLHL26	591	Q53HC5
FEDDDPLPAIGHCKA	FNBP1L	531	Q5T0N5
VRAGHCKTPEQFPFA	CR1	1391	P17927
HVPPESFFKGCVLDV	FCGBP	3096	Q9Y6R7
AHVPPESFFKGCVLD	FCGBP	4296	Q9Y6R7
PGSPFKAHVVPCFDA	FLNA	1146	P21333
AYFECKEKHGIFAPP	CEP350	2546	Q5VT06
PDGFCEQSAFPKHEL	ANK3	2976	Q12955
EFFGKPCSPKDFAHV	ASIC5	186	Q9NY37
AGIAFKVADPTPFHI	CBR1	91	P16152
LLSEFPDKFGSCVPH	DLG4	551	P78352
DLHVFIEVFGPPCEA	KHDRBS1	226	Q07666
AAAPVKGEHFCLPEF	KLF15	111	Q9UIH9
LDIYCPHVPFIFKGD	B3GNT7	226	Q8NFL0
VPGHKFCFPCSREFI	IRF2BP1	521	Q8IU81
LKEFSDILPPGHFTC	LINGO4	396	Q6UY18
HDGKIFFCTSQDIPP	PRDM4	506	Q9UKN5
PLPVCGDIKVEFFHK	PTEN	246	P60484
PFSGPHEINHFFCEI	OR2A1;	166	Q8NGT9
PPAAEKCNAGFFHTL	LAMA4	61	Q16363
HDEACFSLAIPFDPK	NXF2	416	Q9GZY0
GPNVIDHFICDLFPL	OR4C5	191	Q8NGB2
AVHLPFCGPNEVDSF	OR4F4	156	Q96R69
FKDCDGHYLAPVGPA	FSCN2	221	O14926
CCGKLDHINFPVFEP	SMG8	641	Q8ND04
LRPFFEPCLHDGGKN	ERMAP	391	Q96PL5
FHCDPLVEDGIPEFS	IGF2R	2246	P11717
CKLVPPHETFGFKVA	SUSD3	91	Q96L08
LTGIKPPEFFFHCMA	POLR1A	956	O95602
HGAGEKLPCLRVFAF	TMEM132C	161	Q8N3T6
LDAFPEDFCRHKVLP	SCYL1	301	Q96KG9
HPDLVCLAPFADFDK	TDRD9	946	Q8NDG6
AFQFGHFVGPICLPE	OVCH2	151	Q7RTZ1
FADCDGFKIPILGVH	RASGRP3	291	Q8IV61
KRTFPLCFDDHDPAV	SMARCB1	161	Q12824
VIHCDFFKLDPRSGG	TFB2M	146	Q9H5Q4
AGLPVCTPEKDFAEH	PROZ	276	P22891
LVGFKLFLPEGPCDH	SKIV2L	901	Q15477
FHPFTPCIAVADKDS	RPTOR	1031	Q8N122
ADCPGKLFIFHSSLP	SEC24D	571	O94855
HHELKPLDICEFPFG	SMAD5	101	Q99717
HELKPLECCEFPFGS	SMAD1	101	Q15797
IHHFNEGKEFPPCAI	ASPA	206	P45381
IERAKNCGHIPFFFP	ASCC3	736	Q8N3C0
VFGAHKDCEVAPLPT	TRIM54	151	Q9BYV2
AFAICFDAPGVRPHL	PHETA2	86	Q6ICB4
DERGPCFAFEGHKLI	VPS11	261	Q9H270
SPEKFSVPHVCARFG	SEC16A	1441	O15027
EKFHLGPFPCDICGR	ZBTB41	511	Q5SVQ8
CLPDASHVFPAGKAI	ST14	731	Q9Y5Y6
IFSIHLKRDGCSFPP	TRIM75	266	A6NK02
GKCFLDRFPPDSFVH	VPS16	406	Q9H269
KAHPEVAEAGIGCPF	TRAF1	76	Q13077
PYGFKGQDCDVPIHA	SLIT2	946	O94813
LPNVDFVGGFHCKPA	UGT2B11	271	O75310
PFPELHCAALKVFTA	PSMD5	406	Q16401
FLPNVDFVGGLHCKP	UGT2B15	271	P54855
FLPNVDFVGGLHCKP	UGT2B17	271	O75795
AHKVGITPPCFNLFA	TYK2	61	P29597
TFIPHDKGPAAIEEC	AGL	356	P35573