Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	vesicle cargo loading	CTAGE9 CTAGE8 CTAGE15 CTAGE6 CTAGE4 SEC23B	1.54e-09	36	66	6	GO:0035459
GeneOntologyBiologicalProcess	endoplasmic reticulum to Golgi vesicle-mediated transport	CTAGE9 CTAGE8 CTAGE15 CTAGE6 CTAGE4 SEC23B	1.18e-05	159	66	6	GO:0006888
GeneOntologyCellularComponent	endoplasmic reticulum exit site	CTAGE9 CTAGE8 CTAGE15 CTAGE6 CTAGE4 SEC23B	6.42e-09	42	72	6	GO:0070971
GeneOntologyCellularComponent	extracellular matrix	MMP25 LINGO1 ELFN1 MMP28 ADAMTS17 CCDC80 NTN1 ADAMTS5 IMPG2	4.08e-04	656	72	9	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	MMP25 LINGO1 ELFN1 MMP28 ADAMTS17 CCDC80 NTN1 ADAMTS5 IMPG2	4.17e-04	658	72	9	GO:0030312
Domain	NPIP	NPIPB13 NPIPB3 NPIPB5	1.12e-05	14	60	3	IPR009443
Domain	-	ZYG11A LRRC75B LINGO1 ELFN1 PKD1 FBXO33 PHLPP2	7.34e-05	321	60	7	3.80.10.10
Domain	L_dom-like	ZYG11A LRRC75B LINGO1 ELFN1 PKD1 FBXO33 PHLPP2	8.40e-05	328	60	7	IPR032675
Domain	WSC	WSCD1 PKD1	1.01e-04	5	60	2	SM00321
Domain	WSC_carb-bd	WSCD1 PKD1	1.01e-04	5	60	2	IPR002889
Domain	WSC	WSCD1 PKD1	1.01e-04	5	60	2	PF01822
Domain	WSC	WSCD1 PKD1	1.01e-04	5	60	2	PS51212
Domain	MetalloPept_cat_dom	MMP25 MMP28 ADAMTS17 ADAMTS5	1.33e-04	81	60	4	IPR024079
Domain	-	MMP25 MMP28 ADAMTS17 ADAMTS5	1.33e-04	81	60	4	3.40.390.10
Domain	ZINC_PROTEASE	MMP25 MMP28 ADAMTS17 ADAMTS5	2.77e-04	98	60	4	PS00142
Domain	CYSTEINE_SWITCH	MMP25 MMP28 ADAMTS17	3.08e-04	41	60	3	PS00546
Domain	Pept_M10_metallopeptidase	MMP25 MMP28 ADAMTS17	3.55e-04	43	60	3	IPR001818
Domain	VDCCAlpha1	CACNA1F CACNA1H	4.49e-04	10	60	2	IPR002077
Domain	Pept_M10A_stromelysin-type	MMP25 MMP28	1.50e-03	18	60	2	IPR016293
Domain	Leu-rich_rpt	LRRC75B LINGO1 ELFN1 PKD1 PHLPP2	1.77e-03	271	60	5	IPR001611
Domain	PG_binding_1	MMP25 MMP28	1.86e-03	20	60	2	PF01471
Domain	Peptidoglycan-bd-like	MMP25 MMP28	1.86e-03	20	60	2	IPR002477
Domain	LRR_8	LINGO1 ELFN1 PKD1 PHLPP2	2.22e-03	171	60	4	PF13855
Domain	ADAM_spacer1	ADAMTS17 ADAMTS5	2.46e-03	23	60	2	IPR010294
Domain	Hemopexin-like_dom	MMP25 MMP28	2.46e-03	23	60	2	IPR000585
Domain	Hemopexin-like_repeat	MMP25 MMP28	2.46e-03	23	60	2	IPR018487
Domain	M10A_MMP	MMP25 MMP28	2.46e-03	23	60	2	IPR033739
Domain	ADAM_spacer1	ADAMTS17 ADAMTS5	2.46e-03	23	60	2	PF05986
Domain	Hemopexin	MMP25 MMP28	2.46e-03	23	60	2	PF00045
Domain	HEMOPEXIN	MMP25 MMP28	2.46e-03	23	60	2	PS00024
Domain	-	MMP25 MMP28	2.46e-03	23	60	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP25 MMP28	2.46e-03	23	60	2	PS51642
Domain	HX	MMP25 MMP28	2.46e-03	23	60	2	SM00120
Domain	Pept_M10A	MMP25 MMP28	2.46e-03	23	60	2	IPR021190
Domain	Leu-rich_rpt_typical-subtyp	LINGO1 ELFN1 PKD1 PHLPP2	2.51e-03	177	60	4	IPR003591
Domain	LRR_TYP	LINGO1 ELFN1 PKD1 PHLPP2	2.51e-03	177	60	4	SM00369
Domain	Peptidase_M10	MMP25 MMP28	2.68e-03	24	60	2	PF00413
Domain	Peptidase_M12B_ADAM-TS	ADAMTS17 ADAMTS5	2.68e-03	24	60	2	IPR013273
Domain	Cys-rich_flank_reg_C	LINGO1 ELFN1 PKD1	3.04e-03	90	60	3	IPR000483
Domain	LRRCT	LINGO1 ELFN1 PKD1	3.04e-03	90	60	3	SM00082
Domain	ACR	ADAMTS17 ADAMTS5	3.38e-03	27	60	2	SM00608
Domain	ADAM_Cys-rich	ADAMTS17 ADAMTS5	3.38e-03	27	60	2	IPR006586
Domain	ZnMc	MMP25 MMP28	3.90e-03	29	60	2	SM00235
Domain	Peptidase_Metallo	MMP25 MMP28	3.90e-03	29	60	2	IPR006026
Domain	LRR	LINGO1 ELFN1 PKD1 PHLPP2	3.97e-03	201	60	4	PS51450
Pubmed	Response of BALB/c mice to leishmanial infection.	SLC11A1 TAL1	4.35e-06	2	73	2	3930154
Pubmed	Divergent origins and concerted expansion of two segmental duplications on chromosome 16.	NPIPB3 NPIPB5	1.30e-05	3	73	2	11948212
Pubmed	Deletion of Mea6 in Cerebellar Granule Cells Impairs Synaptic Development and Motor Performance.	CTAGE9 CTAGE8	2.60e-05	4	73	2	33718348
Pubmed	Specific expression and regulation of the new melanoma inhibitory activity-related gene MIA2 in hepatocytes.	CTAGE9 CTAGE8	2.60e-05	4	73	2	12586826
Pubmed	Mea6 controls VLDL transport through the coordinated regulation of COPII assembly.	CTAGE9 CTAGE8	2.60e-05	4	73	2	27311593
Pubmed	MEA6 Deficiency Impairs Cerebellar Development and Motor Performance by Tethering Protein Trafficking.	CTAGE9 CTAGE8	2.60e-05	4	73	2	31244610
Pubmed	Isolated polycystic liver disease genes define effectors of polycystin-1 function.	GANAB PKD1	2.60e-05	4	73	2	28375157
Pubmed	Reduced cholesterol and triglycerides in mice with a mutation in Mia2, a liver protein that localizes to ER exit sites.	CTAGE9 CTAGE8	2.60e-05	4	73	2	21807889
Pubmed	The sequence and analysis of duplication-rich human chromosome 16.	NPIPB11 NPIPB3 CACNA1H PHLPP2	3.98e-05	90	73	4	15616553
Pubmed	Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.	CTAGE9 CTAGE8	4.33e-05	5	73	2	18630941
Pubmed	cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing.	CTAGE9 CTAGE4	4.33e-05	5	73	2	12839582
Pubmed	Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.	CTAGE9 CTAGE8	4.33e-05	5	73	2	19131326
Pubmed	Characterization and expression pattern of the novel MIA homolog TANGO.	CTAGE9 CTAGE8	4.33e-05	5	73	2	15183315
Pubmed	Mea6/cTAGE5 cooperates with TRAPPC12 to regulate PTN secretion and white matter development.	CTAGE9 CTAGE8	4.33e-05	5	73	2	38439956
Pubmed	A tissue-specific atlas of mouse protein phosphorylation and expression.	CTAGE9 CTAGE8	4.33e-05	5	73	2	21183079
Pubmed	Mechanism for Selective Synaptic Wiring of Rod Photoreceptors into the Retinal Circuitry and Its Role in Vision.	CACNA1F ELFN1	4.33e-05	5	73	2	26402607
Pubmed	Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1.	NTN1 TAL1	6.48e-05	6	73	2	33504783
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1F CACNA1H	9.06e-05	7	73	2	12900400
Pubmed	cTAGE5 deletion in pancreatic β cells impairs proinsulin trafficking and insulin biogenesis in mice.	CTAGE9 CTAGE8	9.06e-05	7	73	2	29133483
Pubmed	Polycystic Kidney Disease, Autosomal Dominant	GANAB PKD1	9.06e-05	7	73	2	20301424
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1F CACNA1H	1.21e-04	8	73	2	28330839
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1F CACNA1H	1.55e-04	9	73	2	16382099
Pubmed	Misexpression of MIA disrupts lung morphogenesis and causes neonatal death.	CTAGE9 CTAGE8	1.55e-04	9	73	2	18342301
Pubmed	Interplay between cell-adhesion molecules governs synaptic wiring of cone photoreceptors.	CACNA1F ELFN1	1.93e-04	10	73	2	32879010
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	MLF2 GANAB TBC1D4 MAGED2 IPO4 SRPRB SEC23B	1.98e-04	571	73	7	37167062
Pubmed	NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.	CACNA1F CACNA1H	2.36e-04	11	73	2	18809727
Pubmed	The Auxiliary Calcium Channel Subunit α2δ4 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors.	CACNA1F ELFN1	2.36e-04	11	73	2	28262416
Pubmed	Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.	ADAMTS17 ADAMTS5	2.83e-04	12	73	2	25770910
Pubmed	Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice.	CTAGE9 CTAGE8	3.34e-04	13	73	2	11839810
Pubmed	USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling.	USP49 PHLPP2	3.34e-04	13	73	2	28363942
Pubmed	Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding.	GANAB MAGED2 CYP2U1 TIMM29 NDUFS4 RPL15	4.37e-04	464	73	6	32457219
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	GANAB ATAD2B POGZ IPO4 SEC23B RPL15 FTSJ3	4.44e-04	653	73	7	22586326
Pubmed	cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development.	CTAGE9 CTAGE8	4.48e-04	15	73	2	30224460
Pubmed	Screening E3 substrates using a live phage display library.	NPIPB3 RPL15	5.79e-04	17	73	2	24124579
Pubmed	SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse.	MLF2 LINGO1	5.79e-04	17	73	2	31171447
Pubmed	SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.	MMP25 LRRC75B ARHGAP23 TPRN NRG2 NPIPB3 FBXO33 NDUFS4	6.61e-04	915	73	8	32393512
Pubmed	Human transcription factor protein interaction networks.	SIN3B GANAB MAGED2 MRPS14 TIMM29 POGZ TAL1 SEC23B MYO5C FTSJ3	7.83e-04	1429	73	10	35140242
Pubmed	Functional interactions between matrix metalloproteinases and glycosaminoglycans.	MMP25 MMP28	9.77e-04	22	73	2	23421805
Pubmed	Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.	MLF2 MAGED2	9.77e-04	22	73	2	18095154
Pubmed	Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.	SIN3B TPRN MYO5C RPL15 FTSJ3	9.88e-04	361	73	5	30344098
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	MAGED2 MRPS14 IPO4 SRPRB RPL15 FTSJ3	1.03e-03	547	73	6	37267103
Pubmed	Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.	MMP25 ADAMTS5 RPL15	1.17e-03	98	73	3	19834535
Pubmed	Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells.	IPO4 SRPRB	1.37e-03	26	73	2	23181366
Pubmed	Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression.	MYO1G GANAB MAGED2 MRPS14 FTSJ3	1.60e-03	403	73	5	35253629
Pubmed	Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II.	GANAB IPO4 RPL15 FTSJ3	1.76e-03	244	73	4	30349055
Pubmed	ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.	SIN3B MLF2 TBC1D4 MAGED2 IPO4 RPL15	2.00e-03	624	73	6	33729478
Pubmed	Genome-wide searching of rare genetic variants in WTCCC data.	AARD ZDHHC1	2.07e-03	32	73	2	20549515
Interaction	CTAGE1 interactions	CTAGE8 CTAGE15 CTAGE6 CTAGE4	1.91e-08	10	64	4	int:CTAGE1
Interaction	MIA2 interactions	CTAGE8 CTAGE15 CTAGE6 CTAGE4 SRPRB	2.97e-05	113	64	5	int:MIA2
Cytoband	7q35	CTAGE8 CTAGE15 CTAGE6 CTAGE4	1.89e-06	55	73	4	7q35
Cytoband	Ensembl 112 genes in cytogenetic band chr7q35	CTAGE8 CTAGE15 CTAGE6 CTAGE4	3.93e-06	66	73	4	chr7q35
Cytoband	16p12.2	NPIPB4 NPIPB3 NPIPB5	2.88e-05	37	73	3	16p12.2
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	NPIPB4 NPIPB3 NPIPB5	2.65e-03	172	73	3	chr16p12
Cytoband	16p11.2	NPIPB13 NPIPB12 NPIPB11	3.56e-03	191	73	3	16p11.2
GeneFamily	CTAGE family	CTAGE9 CTAGE8 CTAGE15 CTAGE6 CTAGE4	4.29e-10	15	51	5	907
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS17 ADAMTS5	1.29e-03	19	51	2	50
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP25 MMP28	2.07e-03	24	51	2	891
GeneFamily	Calcium voltage-gated channel subunits	CACNA1F CACNA1H	2.43e-03	26	51	2	253
GeneFamily	Cyclins\|F-boxes other	FBXO31 FBXO33	5.41e-03	39	51	2	560
Disease	Autosomal dominant polycystic kidney disease	GANAB PKD1	1.34e-05	3	63	2	cv:C0085413
Disease	netrin-4 measurement	MLF2 NTN1	2.68e-05	4	63	2	EFO_0020592
Disease	Polycystic kidney disease, type 2	GANAB PKD1	9.36e-05	7	63	2	C2751306
Disease	Polycystic Kidney, Type 1 Autosomal Dominant Disease	GANAB PKD1	1.25e-04	8	63	2	C0887850
Disease	Polycystic Kidney, Autosomal Dominant	GANAB PKD1	1.60e-04	9	63	2	C0085413

Protein segments in the cluster

Peptide	Gene	Start	Entry
RENRSETWRRRRFRP	ERICH3	246	Q5RHP9
RRLTRAFQWAVQRAI	AARD	61	Q4LEZ3
RASQSIWERFRLSRR	ELFN1	771	P0C7U0
LLFLWRSFRSVRSRL	CTAGE4	56	Q8IX94
LLFLWRSFRSVRSRL	CTAGE6	56	Q86UF2
LLFLWRSFRSVRSRL	CTAGE8	56	P0CG41
LLFLWRSFRSVRSRL	CTAGE9	56	A4FU28
LLFLWRSFRSVRSRL	CTAGE15	56	A4D2H0
WRRRRRSISRARQVE	ADAMTS5	256	Q9UNA0
RDFRFNIRALRLWSL	ASB10	96	Q8WXI3
RFWRKTRSRNSRFRC	CPA6	251	Q8N4T0
RWFRRRRNQDRPSLL	CERS2	116	Q96G23
SRDWRERRNAIRLTS	ADAMTS17	216	Q8TE56
QSLENFLSRFRWRRR	CCDC80	766	Q76M96
FLSRFRWRRRLLVIS	CCDC80	771	Q76M96
SRIRRGDQSLWIRSR	NTN1	526	O95631
RAWRSNRRRQEGLRS	NPIPB3	106	Q92617
RLLLRTWISRARQQT	RFNG	76	Q9Y644
HRVRYRRGLWRTRQI	IQCM	336	A0A1B0GVH7
RAWRSNRRRQEGLRS	NPIPB12	106	F8W0I5
AELTNRRRGRLRWFS	CACNA1F	441	O60840
LVRRRRRYALSGSVW	MMP25	101	Q9NPA2
RRNRWLIAVTDFQTR	C19orf81	131	C9J6K1
ARRASRTRLAAWARR	MAGED2	226	Q9UNF1
AFRVRRKSRRRSQWG	ATAD2B	1131	Q9ULI0
AARVARWRRLRLQQL	FBXO33	21	Q7Z6M2
KFRRILHTDTIWRRR	FBXO31	96	Q5XUX0
RRWRRSRLNGLAAQR	NRG2	741	O14511
RRSSQQWRRQPTRLF	MRGPRD	206	Q8TDS7
RVRWLREIQSTLRER	LRRC75B	31	Q2VPJ9
RLLWVFRRRWRLNFN	LINGO1	376	Q96FE5
RAWRSNRRRQEGLRS	NPIPB5	106	A8MRT5
LRLRWSRFARVLLTR	SLC11A1	391	P49279
RAWRSNRRRQEGLRS	NPIPB4	106	C9JG80
RSEWIRNRAIWRQLR	MOGAT3	76	Q86VF5
RAWRSNRRRQEGLRS	NPIPB11	106	E5RHQ5
LTRWRTRYKTIRINL	MCHR2	141	Q969V1
LRRRSWLSSRTRAAG	CYP2U1	81	Q7Z449
VKRRSLRLYARWQSR	CACNA1H	471	O95180
RRARRFFLRCIIWNT	DYSF	1806	O75923
FAAVLTRRRLNTRWR	IPO4	56	Q8TEX9
TRRRLNTRWRRLAAE	IPO4	61	Q8TEX9
RQTLWRRRAVAVAAL	NDUFS4	11	O43181
WRRETSRFRQQRPLE	MLF2	196	Q15773
RQWTRFVRGRPRRFT	PKD1	3961	P98161
RAWRSNRRRQEGLRS	NPIPB13	106	A6NJU9
DERWSLSRRRGRNLF	MMP28	221	Q9H239
LVFWKLIRSRRSSQR	SRPRB	51	Q9Y5M8
MAAAALRRFWSRRRA	TIMM29	1	Q9BSF4
VVRRIFTNSRERWRQ	TAL1	186	P17542
AVAARRRRSWASLVL	GANAB	6	Q14697
RRIRRWLRRFQASQG	POGZ	1001	Q7Z3K3
RSLLNWRTKLRRYVA	FTSJ3	306	Q8IY81
KFRRRWQSEQARALR	SIN3B	1021	O75182
TERQWLIRRRRSILF	IMPG2	71	Q9BZV3
STQRRIRVTTIARNW	SEC23B	491	Q15437
ALAQLLTRRRRTWRD	SLC6A18	586	Q96N87
RTRIQFIRWSHTRIF	SPATA19	111	Q7Z5L4
KRRWRLSRIVFRHLA	MRPS14	101	O60783
NWRSTTRLRIIRLRD	SHF	81	Q7M4L6
NRRSRFGSRERDWLR	PHLPP2	11	Q6ZVD8
GSRRAAWRRRNTLQL	RPL15	186	P61313
TRRRRSSWRRHTVVV	ARHGAP23	1396	Q9P227
LRVLFRRLENRRWSS	FAM90A2P	391	Q658T7
WRSRRVFLLVRRTRA	TUG1	51	A0A6I8PU40
TALWYRRQRLLARTL	USP49	141	Q70CQ1
RRQRLLARTLRLWFE	USP49	146	Q70CQ1
TPRRISWRQRIFLRV	TBC1D4	766	O60343
RWRVNFIRHLRSRRE	ZNF496	416	Q96IT1
RTATALADRAIRWQR	TPRN	401	Q4KMQ1
WLRSRNSELRQLRRR	WSCD1	101	Q658N2
WRRRQRRLRGASSAE	TNFRSF13C	101	Q96RJ3
RQLWISRDFQRRTLL	ZYG11A	631	Q6WRX3
TRRRQSPWTRFQWRR	ZDHHC1	441	Q8WTX9
ARWRCRRLRAIYTIM	MYO1G	726	B0I1T2
ARAWLARRRFQSIRR	MYO5C	866	Q9NQX4